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Collagen AND PRP

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https://www.readbyqxmd.com/read/28217215/the-bone-regeneration-using-bone-marrow-stromal-cells-with-moderate-concentration-platelet-rich-plasma-in-femoral-segmental-defect-of-rats
#1
Junichi Yamakawa, Junichi Hashimoto, Mitsuo Takano, Michiaki Takagi
BACKGROUND: Platelet-rich plasma (PRP) can provide an assortment of growth factors, but how PRP effects bone regeneration is still unknown. The aim of the study was to explore an optimal method of using PRP and bone marrow stromal cells (BMSCs). METHODS: An in vitro experiment was first conducted to determine an appropriate quantity of PRP. BMSCs were cultured with PRP of different concentrations to assess cell proliferation and osteogenic differentiation. Following the in vitro study, a rat femoral segmental defect model was used...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/28202394/platelet-rich-plasma-prp-induces-chondroprotection-via-increasing-autophagy-anti-inflammatory-markers-and-decreasing-apoptosis-in-human-osteoarthritic-cartilage
#2
Mayssam Moussa, Daniel Lajeunesse, George Hilal, Oula El Atat, Gaby Haykal, Rim Serhal, Antonio Chalhoub, Charbel Khalil, Nada Alaaeddine
OBJECTIVES: Autophagy constitutes a defense mechanism to overcome aging and apoptosis in osteoarthritic cartilage. Several cytokines and transcription factors are linked to autophagy and play an important role in the degradative cascade in osteoarthritis (OA). Cell therapy such as platelet rich plasma (PRP) has recently emerged as a promising therapeutic tool for many diseases including OA. However, its mechanism of action on improving cartilage repair remains to be determined. The purpose of this study is to investigate the effect of PRP on osteoarthritic chondrocytes and to elucidate the mechanism by which PRP contributes to cartilage regeneration...
February 13, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28178294/histological-observation-of-a-gelatin-sponge-transplant-loaded-with-bone-marrow-derived-mesenchymal-stem-cells-combined-with-platelet-rich-plasma-in-repairing-an-annulus-defect
#3
Xiang Xu, Jianzhong Hu, Hongbin Lu
OBJECTIVE: To research the histological characteristics of a gelatin sponge transplant loaded with goat BMSCs (bone marrow-derived mesenchymal stem cells) combined with PRP (platelet-rich plasma) in repairing an annulus defect. METHOD: BMSCs were separated from the iliac crest of goats, sub-cultured and identified after the third generation. Then, PRP was obtained using blood from the jugular vein of goats via two degrees of centrifugation. In the animal experiments, the goats were divided into the following three groups: a sham group, an injury group and a therapeutic group...
2017: PloS One
https://www.readbyqxmd.com/read/28150526/evaluation-of-an-automated-light-transmission-aggregometry
#4
Li-Qin Ling, Juan Liao, Qian Niu, Xia Wang, Jin Jia, Cheng-Hua Zuo, Hong Jiang, Jing Zhou
Light transmission aggregometry (LTA) is the "gold standard" for platelet function assessment, but it is time-consuming and labor intensive. Recently, an automated platelet aggregation method has been developed on a routine coagulation analyzer (Sysmex CS-2100i). In this study, the performances of CS-2100i including repeatability, correlation with a reference aggregometer (Chrono-log Model 700), and the threshold limitation of platelet counts in platelet-rich plasma (PRP) were evaluated for clinical use. The agonists were adenosine diphosphate (ADP), arachidonic acid, collagen, epinephrine, and ristocetin...
February 2, 2017: Platelets
https://www.readbyqxmd.com/read/28127950/kartogenin-with-prp-promotes-the-formation-of-fibrocartilage-zone-in-the-tendon-bone-interface
#5
Yiqin Zhou, Jianying Zhang, Jinsong Yang, Manoj Narava, Guangyi Zhao, Ting Yuan, Haishan Wu, Nigel Zheng, MaCalus V Hogan, James H-C Wang
Treatment of tendon-bone junction injuries is a challenge because tendon-bone interface often heals poorly and the fibrocartilage zone, which reduces stress concentration, at the interface is not formed. In this study, we used a compound called kartogenin (KGN) with platelet-rich plasma (PRP) to induce the formation of fibrocartilage zone in a rat tendon graft-bone tunnel model. The experimental rats received KGN-PRP or PRP injections in the tendon graft-bone tunnel interface. The control group received saline...
January 27, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28127660/comparative-study-using-autologous-fat-grafts-plus-platelet-rich-plasma-with-or-without-fractional-co2-laser-resurfacing-in-treatment-of-acne-scars-analysis-of-outcomes-and-satisfaction-with-face-q
#6
S Tenna, A Cogliandro, M Barone, Vincenzo Panasiti, M Tirindelli, Carolina Nobile, Paolo Persichetti
BACKGROUND: A multitude of options are traditionally used for the treatment of acne scars; however, newer treatment modalities are emerging to decrease the propensity for post-inflammatory hyperpigmentation and upregulate new collagen production. The aim of this study was to evaluate the efficacy of nanofat and platelet-rich plasma (PRP) infiltration alone and combined with fractional CO2 laser resurfacing to improve atrophic scars of the face. METHODS: From March 2014 to June 2015, 30 patients with atrophic acne scars on the cheeks were selected for this study...
January 26, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28119114/evaluation-of-platelet-rich-plasma-gel-potential-in-acceleration-of-wound-healing-duration-in-patients-underwent-pilonidal-sinus-surgery-a-randomized-controlled-parallel-clinical-trial
#7
Saeed Mohammadi, Shirzad Nasiri, Mohammad Hossein Mohammadi, Ashraf Malek Mohammadi, Mohsen Nikbakht, Mahdi Zahed Panah, Hiva Safar, Shayan Mostafaei, Amir Hossein Norooznezhad, Ahmad Reza Soroosh, Kamran Alimoghaddam, Ardeshir Ghavamzadeh
OBJECTIVES: One of the most important surgical issues applied in the treatment of pilonidal sinus disease is wound healing. The aim of this study was to investigate the possible effect of platelet-rich plasma (PRP) gel on accelerating wound healing in these patients. METHODS: In this randomized, controlled, parallel group clinical trial, 110 patients were randomly allocated into two parallel groups with the same size (controls and treatment arm) after meeting inclusion and exclusion criteria...
January 4, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28116973/human-adipose-derived-mesenchymal-stem-cells-for-osseous-rehabilitation-of-induced-osteoradionecrosis
#8
Jeffrey R Janus, Ryan S Jackson, Katherine A Lees, Stephen G Voss, Zachary C Wilson, Nicholas B Remmes, Michael G Keeney, Joaquin J Garcia, Serban San Marina
Objective Human adipose-derived mesenchymal stem cells (ADSCs) were used to rehabilitate bone damaged by osteoradionecrosis (ORN) in an established animal model. Study Design Prospective animal study. Setting Academic department laboratory. Subjects and Methods After institutional review board and Institutional Animal Care and Use Committee approval, 24 athymic nude rats were divided into 5 groups: 4 groups irradiated (20 Gy) by brachytherapy catheter placed at the left hemimandible and 1 mock irradiation control (n = 4)...
January 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28105983/effect-of-bone-marrow-aspirate-concentrate-platelet-rich-plasma-on-tendon-derived-stem-cells-and-rotator-cuff-tendon-tear
#9
Sun Jeong Kim, Da Hyun Song, Jong Wook Park, Silvia Park, Sang Jun Kim
Bone marrow aspirate concentrates (BMACs) and platelet-rich plasma (PRP) are good sources to control the differentiation of tendon derived stem cells (TDSCs) but there has been no study about the effect of BMAC-PRP complex on TDSCs and tendinopathy. The aim of this study was to investigate the effect of BMAC-PRP on the TDSCs and to find the therapeutic effect of BMAC-PRP on the rotator cuff tendon tear. Chondrogenic and osteogenic potential of TDSCs decreased, but adipogenic potential of TDSCs revealed no significant difference when they were co-cultured with BMAC-PRP...
January 20, 2017: Cell Transplantation
https://www.readbyqxmd.com/read/28061032/effects-of-platelet-rich-plasma-with-concomitant-use-of-a-corticosteroid-on-tenocytes-from-degenerative-rotator-cuff-tears-in-interleukin-1%C3%AE-induced-tendinopathic-conditions
#10
Chris Hyunchul Jo, Seung Yeon Lee, Kang Sup Yoon, Sue Shin
BACKGROUND: A corticosteroid injection is commonly used to treat tendinopathy, but it has been associated with negative effects on tendon homeostasis. Platelet-rich plasma (PRP) is known to have proliferative and anabolic effects as well as cytoprotective effects against corticosteroids on tenocytes. However, the combined effects of a corticosteroid and PRP on the anti-inflammatory, matrix synthesis, and cytoprotective potential of tenocytes in conditions simulating tendinopathy have not been investigated...
January 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28027872/the-effect-of-platelet-rich-plasma-on-achilles-tendon-healing-in-a-rabbit-model
#11
Masaki Takamura, Toshito Yasuda, Atsushi Nakano, Hiroaki Shima, Masashi Neo
OBJECTIVE: The aim of the present study was to evaluate the effects of PRP on Achilles tendon healing in rabbits during the inflammatory, proliferative, and remodeling phases by histological examination and quantitative assessments. METHODS: Fifty mature male Japanese albino rabbits with severed Achilles tendons were divided into two equal groups and treated with platelet-rich plasma (PRP) or left untreated. Tendon tissue was harvested at 1, 2, 3, 4, and 6 weeks after treatment, and sections were stained with hematoxylin-eosin and monoclonal antibodies against CD31 and type I collagen...
January 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/28019703/a-clinically-relevant-hydrogel-based-on-hyaluronic-acid-and-platelet-rich-plasma-as-a-carrier-for-mesenchymal-stem-cells-rheological-and-biological-characterization
#12
Gianluca Vadalà, Fabrizio Russo, Maria Musumeci, Matteo D'Este, Caterina Cattani, Giuseppina Catanzaro, Maria Cristina Tirindelli, Lorenza Lazzari, Mauro Alini, Rosaria Giordano, Vincenzo Denaro
Intervertebral disc regeneration is quickly moving towards clinical applications. However, it is still missing an ideal injectable hydrogel to support mesenchymal stem cells (MSC) delivery. Herein, a new injectable hydrogel composed of platelet rich plasma (PRP) and hyaluronic acid (HA) blended with batroxobin (BTX) as gelling agent, was designed to generate a clinically relevant cell carrier for disc regeneration. PRP/HA/BTX blend was tested for rheological properties. Amplitude sweep, frequency sweep and rotational measurements were performed and viscoelastic properties were evaluated...
December 26, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27929701/effect-of-serum-and-platelet-rich-plasma-on-human-early-or-advanced-degenerative-meniscus-cells
#13
Undine Freymann, Lucia Degrassi, Jan Philipp Krüger, Sebastian Metzlaff, Michaela Endres, Wolf Petersen
PURPOSE: The purpose of this in vitro study was to evaluate the migratory, proliferating & extracellular matrix (ECM) forming effect of human serum (HS) and platelet-rich plasma (PRP) on meniscus cells derived from human knees with early or advanced degenerative changes. MATERIALS AND METHODS: Medial menisci from knees with early degenerative changes (n=5; mean Kellgren score of 1) undergoing arthroscopic meniscal surgery and advanced degenerative changes (n=5; mean Kellgren score of 4) undergoing total knee replacement were collected...
December 8, 2016: Connective Tissue Research
https://www.readbyqxmd.com/read/27904271/histologic-evidence-of-new-collagen-formulation-using-platelet-rich-plasma-in-skin-rejuvenation-a-prospective-controlled-clinical-study
#14
Ozlem Karabudak Abuaf, Hamza Yildiz, Hüseyin Baloglu, Memet Ersan Bilgili, Hasan Aktug Simsek, Bilal Dogan
BACKGROUND: Platelet-rich plasma (PRP) is an autologous concentration of human platelets contained in a small volume of plasma and has recently been shown to accelerate rejuvenate aging skin by various growth factors and cell adhesion molecules. OBJECTIVE: This study was conducted to evaluate the efficacy and safety of intradermal injection of PRP in the human facial rejuvenation. METHODS: This study was a prospective, single-center, single-dose, open-label, non-randomized controlled clinical study...
December 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27887732/expressions-of-pathologic-markers-in-prp-based-chondrogenic-differentiation-of-human-adipose-derived-stem-cells
#15
Arezou Pakfar, Shiva Irani, Hana Hanaee-Ahvaz
BACKGROUND: Optimization of the differentiation medium through using autologous factors such as PRP is of great consideration, but due to the complex, variable and undefined composition of PRP on one hand and lack of control over the absolute regulatory mechanisms in in vitro conditions or disrupted and different mechanisms in diseased tissue microenvironments in in vivo conditions on the other hand, it is complicated and rather unpredictable to get the desired effects of PRP making it inevitable to monitor the possible pathologic or undesired differentiation pathways and therapeutic effects of PRP...
November 12, 2016: Tissue & Cell
https://www.readbyqxmd.com/read/27865965/palladin-is-involved-in-platelet-activation-and-arterial-thrombosis
#16
Xuejiao Chen, Xuemei Fan, Juan Tan, Panlai Shi, Xiyi Wang, Jinjin Wang, Ying Kuang, Jian Fei, Junling Liu, Suying Dang, Zhugang Wang
The dynamics of actin cytoskeleton have been shown to play a critical role during platelet activation. Palladin is an actin-associated protein, serving as a cytoskeleton scaffold to bundle actin fibers and actin cross linker. The functional role of palladin on platelet activation has not been investigated. Here, we characterized heterozygous palladin knockout (palladin(+/-)) mice to elucidate the platelet-related functions of palladin. The results showed that palladin was expressed in platelets and moderate palladin deficiency accelerated hemostasis and arterial thrombosis...
January 2017: Thrombosis Research
https://www.readbyqxmd.com/read/27853331/effects-of-platelet-rich-plasma-platelet-rich-fibrin-with-and-without-stromal-cell-derived-factor-1-on-repairing-full-thickness-cartilage-defects-in-knees-of-rabbits
#17
Soghra Bahmanpour, Maryam Ghasemi, Mohsen Sadeghi-Naini, Iraj Ragerdi Kashani
BACKGROUND: The purpose of this study was to create biomaterial scaffolds like platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) containing stromal cell-derived factor-1 (SDF1) as a chemokine to induce hyaline cartilage regeneration of rabbit knee in a full thickness defect. METHODS: We created a full thickness defect in the trochlear groove of thirty-six bilateral knees of eighteen mature male rabbits. The knees were randomly divided into six groups (group I: untreated control, group II: PRP, group III: PRF, group IV: Gelatin+SDF1, group V: PRP+SDF1, and group VI: PRF+SDF1)...
November 2016: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27833116/freeze-dried-platelet-rich-plasma-accelerates-bone-union-with-adequate-rigidity-in-posterolateral-lumbar-fusion-surgery-model-in-rats
#18
Yasuhiro Shiga, Sumihisa Orita, Go Kubota, Hiroto Kamoda, Masaomi Yamashita, Yusuke Matsuura, Kazuyo Yamauchi, Yawara Eguchi, Miyako Suzuki, Kazuhide Inage, Takeshi Sainoh, Jun Sato, Kazuki Fujimoto, Koki Abe, Hirohito Kanamoto, Masahiro Inoue, Hideyuki Kinoshita, Yasuchika Aoki, Tomoaki Toyone, Takeo Furuya, Masao Koda, Kazuhisa Takahashi, Seiji Ohtori
Fresh platelet-rich plasma (PRP) accelerates bone union in rat model. However, fresh PRP has a short half-life. We suggested freeze-dried PRP (FD-PRP) prepared in advance and investigated its efficacy in vivo. Spinal posterolateral fusion was performed on 8-week-old male Sprague-Dawley rats divided into six groups based on the graft materials (n = 10 per group): sham control, artificial bone (A hydroxyapatite-collagen composite) -alone, autologous bone, artificial bone + fresh-PRP, artificial bone + FD-PRP preserved 8 weeks, and artificial bone + human recombinant bone morphogenetic protein 2 (BMP) as a positive control...
November 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27819759/effect-of-platelet-rich-plasma-on-polypropylene-meshes-implanted-in-the-rabbit-vagina-histological-analysis
#19
Natália Gomes Parizzi, Oscar Ávila Rubini, Silvio Henrique Maia de Almeida, Lais Caetano Ireno, Roger Mitio Tashiro, Victor Hugo Tolotto de Carvalho
PURPOSE: The polypropylene mesh (PPM) is used in many surgical interventions because of its good incorporation and accessibility. However, potential mesh-related complications are common. Platelet-rich plasma (PRP) improves the healing of wounds and is inexpensive. Thus, the purpose of this study was to analyze the effect of the PRP-gel coating of a PPM on inflammation, production of collagen, and smooth muscle in the rabbit vagina. MATERIALS AND METHODS: The intervention consisted of a 1...
November 2, 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27718888/platelet-rich-plasma-for-tissue-regeneration-can-be-stored-at-room-temperature-for-at-least-five-days
#20
Gary W Moore, James C Maloney, Robert A Archer, Kerri L Brown, Katarzyna Mayger, Elaine S Bromidge, Mitra F Najafi
BACKGROUND: Autologous platelet-rich plasma (PRP) is gaining increasing use as a wound healing promoter in a variety of clinical settings, including dentistry. Fresh PRP is often used, necessitating daily draws. The present study investigates the possibility of using stored PRP without having to freeze it by storing PRP under variable conditions and assessing growth factor release as a surrogate marker of continued viability. METHODS: Freshly drawn PRP was stored in oxygen permeable and non-oxygen permeable containers under conditions of constant agitation with or without added prostaglandin, intermittent agitation and no agitation, over an 8-day period...
October 8, 2016: British Journal of Biomedical Science
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