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Collagen AND PRP

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https://www.readbyqxmd.com/read/29772339/wound-healing-effects-of-a-curcuma-zedoaria-polysaccharide-with-platelet-rich-plasma-exosomes-assembled-on-chitosan-silk-hydrogel-sponge-in-a-diabetic-rat-model
#1
Ning Xu, Lili Wang, Junjie Guan, Chao Tang, Ning He, Wei Zhang, Shiping Fu
One homogeneous polysaccharide (ZWP) was successfully isolated and purified from the rhizomes of Curcuma zedoaria and the aim of present study was to determine the potential of chitosan/silk hydrogel sponge loaded with platelet-rich plasma exosomes (PRP-Exos), ZWP or PRP-Exos/ZWP on wound-healing in diabetic rats. An in vivo diabetic wound healing study showed that separate or combined treatments all resulted in a wound contraction in diabetic rats, as evidenced by a decrease of ulcer and an increase of epidermal thickness, but PRP-Exos/ZWP combination therapy was more successful in wound closing than either PRP-Exos or ZWP single administration...
May 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29737075/-adjusting-platelet-counts-for-platelet-aggregation-tests
#2
Li-Qin Ling, Xin-Chun Yang, Hao Chen, Chao-Nan Liu, Si Chen, Hong Jiang, Ya-Xiong Jin, Jing Zhou
OBJECTIVE: To explore a better method to adjust platelet counts for light transmission aggregometry (LTA). METHODS: Blood samples from 36 healthy participants aged from 18 to 50 yr. were collected.Platelet-rich plasma (PRP) was diluted using platelet-poor plasma (PPP) and physiological saline (PS),respectively,in a ratio of 1.5,2,2.5 and 3 times. Platelet aggregation was induced by adenosine diphosphate (ADP),arachidonic acid (ARA),collagen (COL), epinephrine (EPI),or ristocetin (RIS)...
March 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29701622/platelet-rich-plasma-versus-tretinoin-in-treatment-of-striae-distensae-a-comparative-study
#3
Hend D Gamil, Samia A Ibrahim, Howyda M Ebrahim, Waleed Albalat
BACKGROUND: Striae distensae (SD) are dermal scars associated with atrophy of the epidermis. OBJECTIVE: To evaluate the effect and safety of intralesional injection of platelet-rich plasma (PRP) versus topical tretinoin 0.05% in treatment of SD. METHODS: Thirty patients (27 females and 3 males) had bilateral striae distensae were enrolled in this study. In every patient, half of the selected striae were treated with PRP intralesional injection...
May 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29682870/comparative-study-of-the-efficacy-of-platelet-rich-plasma-combined-with-carboxytherapy-vs-its-use-with-fractional-carbon-dioxide-laser-in-atrophic-acne-scars
#4
Abdul-Aziz Ibrahim Al Taweel, Abdul-Aziz Abdul-Salam Al Refae, Ahmed Mohamed Hamed, Asmaa Mostafa Kamal
BACKGROUND: Acne scars are a major concerning problem to all acne patients affecting their quality of life. Platelet-rich plasma (PRP) and fractional CO2 laser are innovative treatment modalities for acne scars. Carboxytherapy can also be used to improve scar tissue through the increase in collagen deposition and reorganization, and the improvement in skin texture and tone. AIMS: The aim of this work was to compare the efficacy, safety, and complications of the intradermal injection of PRP combined with carboxytherapy and PRP combined with fractional CO2 laser, in the treatment of atrophic acne scars...
April 22, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29678307/viability-and-functionality-of-mesenchymal-stromal-cells-loaded-on-collagen-microspheres-and-incorporated-into-plasma-clots-for-orthopaedic-application-effect-of-storage-conditions
#5
Olga Wittig, Dylana Diaz-Solano, José Cardier
BACKGROUND: There is evidence showing that human mesenchymal stromal cells (MSC) seeded on collagen microspheres (CM) and incorporated into platelet rich plasma (PRP) clots induce bone formation. For clinical trials it is very important to establish standardization of storage and shipment conditions to ensure the viability and functionality of cellular products. We investigate the effect of storage temperature and time on the viability and functionality of human MSC seeded on CM and included into PRP clots for using in the further clinical application for bone regeneration...
April 5, 2018: Injury
https://www.readbyqxmd.com/read/29657450/current-advances-in-the-treatment-of-medial-and-lateral-epicondylitis
#6
REVIEW
Sandip P Tarpada, Matthew T Morris, Jayson Lian, Sina Rashidi
Despite advances elucidating the causes of lateral and medial epicondylitis, the standard of care remains conservative management with NSAIDs, physical therapy, bracing, and rest. Scar tissue formation provoked by conservative management creates a tendon lacking the biomechanical properties and mechanical strength of normal tendon. The following review analyzes novel therapies to regenerate tendon and regain function in patients with epicondylitis. These treatments include PRP injection, BMAC, collagen-producing cell injection, and stem cell treatments...
March 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29577749/proliferation-migration-and-ecm-formation-potential-of-human-annulus-fibrosus-cells-is-independent-of-degeneration-status
#7
Sylvia Hondke, Mario Cabraja, Jan Philipp Krüger, Stefan Stich, Tony Hartwig, Michael Sittinger, Michaela Endres
Objective The objective was to evaluate the proliferating, migratory and extracellular matrix (ECM) forming potential of annulus fibrosus cells derived from early (edAFC) or advanced (adAFC) degenerative tissue and their usability as a possible cell source for regenerative approaches for AF closure. Design EdAFC ( n = 5 Pfirrman score of 2-3) and adAFC (n = 5 Pfirrman score of 4-5) were isolated from tissue of patients undergoing spine stabilizing surgery. Cell migration on stimulation with human serum (HS), platelet-rich plasma (PRP), and transforming growth factor β-3 (TGFB3) was assessed by migration assay and proliferation was assessed on stimulation with HS...
March 1, 2018: Cartilage
https://www.readbyqxmd.com/read/29574015/effects-of-platelet-rich-plasma-on-tissue-engineered-vascularized-flaps-in-an-in-vivo-chamber
#8
Yoshio Tanaka, Yusuke Hamamoto, Aizezi Niyazi, Tomohisa Nagasao, Masaki Ueno, Yasuhiko Tabata
AIMS: We investigated the reproducibility of creating a vascularized tissue flap in an in vivo tissue engineering chamber by incubating a vascular pedicle imbedded in a collagen sponge with activated platelet-rich plasma (aPRP) and basic fibroblast growth factor (bFGF). METHODS: Collagen sponge soaked with saline (control group), bFGF (Group 1), aPRP (Group 2), and aPRP/controlled release bFGF (Group 3) was implanted with a saphenous arteriovenous pedicle into a tissue engineering chamber, located subcutaneously in the groin of rabbits...
March 7, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29568195/evaluation-of-antithrombotic-activities-of-solanum-xanthocarpum-and-tinospora-cordifolia
#9
Onila Lugun, Sobharani Bhoi, Priyanka Kujur, D Vinay Kumar, William R Surin
Background: Solanum xanthocarpum and Tinospora cordifolia have been reported to exhibit anti-inflammatory, antiarthritic, antioxidant, antiallergic, and hepatoprotective activities. The origins of many of the currently available antithrombotic treatments are from natural products and natural sources. Objective: To investigate the antithrombotic activities of methanolic leaf extracts of S. xanthocarpum (SXME) and T. cordifolia (TCME). Materials and Methods: Antithrombotic activities were assessed by thrombin inhibition assay, thrombin generation assay, platelet adhesion assay on collagen-coated surface, and platelet PAC1-FITC binding by flow cytometry...
January 2018: Pharmacognosy Research
https://www.readbyqxmd.com/read/29564054/enhanced-tendon-to-bone-healing-of-chronic-rotator-cuff-tears-by-bone-marrow-aspirate-concentrate-in-a-rabbit-model
#10
Xiao Ning Liu, Cheol-Jung Yang, Ji Eui Kim, Zhen Wu Du, Ming Ren, Wei Zhang, Hong Yu Zhao, Kyung Ok Kim, Kyu-Cheol Noh
Background: To evaluate the influence of bone marrow aspirate concentrate (BMAC) on tendon-to-bone healing in a rabbit rotator cuff model and to characterize the composition of growth factors in BMAC. Methods: In this in vivo study, 40 rabbits were allocated into five groups: control (C), repair + saline (RS), repair + platelet-rich plasma (PRP; RP), repair + BMAC (RB) and repair + PRP + BMAC (RPB). A tear model was created by supraspinatus tendon transection at the footprint...
March 2018: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/29522657/activated-platelet-rich-plasma-prp-improves-cartilage-regeneration-using-adipose-stem-cells-encapsulated-in-a-3d-alginate-scaffold
#11
Mohammad-Hossein Beigi, Atefeh Atefi, Hamid-Reza Ghanaei, Sheyda Labbaf, Fatemeh Ejeian, Mohammad-Hossein Nasr-Esfahani
In the current study the effect of superimposing platelet-rich plasma (PRP) on different culture mediums in a three-dimensional (3D) alginate scaffold encapsulated with adipose mesenchymal stem cells (ADSCs) for cartilage tissue repair is reported. The 3D alginate scaffolds with co-administration of PRP and/or chondrogenic supplements had a significant effect on the differentiation of ADSCs into mature cartilage, as assessed by evaluation of the expression of cartilage related markers of Sox9, Collagen II, Aggrecan and collagen and glycosaminoglycan assays...
March 9, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29511606/antioxidant-and-antiplatelet-potential-of-different-methanol-fractions-and-flavonols-extracted-from-onion-allium-cepa-l
#12
Eun Young Ko, Shivraj Hariram Nile, Yi-Sook Jung, Young Soo Keum
In this study, we reported the potential of various methanol fractions of onion (MFO) and its components quercetin and quercetin glucosides on platelet aggregation and antioxidant activity. The onion extracts were separated into several fractions using methanol and water. Further, these extracts were analyzed using simple high-performance liquid chromatography-diode array detector method to separate quercetin (Q), quercetin-4'- O -monoglucoside and quercetin-3, 4'- O -diglucoside from onion sample. It was observed that the bioactive compounds were accumulated in the non-polar portions rather than in the polar one...
March 2018: 3 Biotech
https://www.readbyqxmd.com/read/29451945/the-effects-of-platelet-rich-plasma-and-activated-collagen-on-wound-healing-in-primary-total-joint-arthroplasty
#13
David C Evans, Bruce G Evans
Wound healing remains a concern in primary total joint arthroplasty, given the risk of deep infections arising from hematomas, wound separations, and superficial infections. If wound additives can prevent these early complications, their universal application would be cost-effective. This study examined whether 2 wound additives, platelet-rich plasma (PRP) and activated collagen, would improve postoperative wound healing and reduce complications in primary total joint arthroplasty. A prospective, randomized controlled study was conducted using 3 cohorts with 30 patients each (group 1: PRP; group 2: activated collagen; and group 3: control)...
March 1, 2018: Orthopedics
https://www.readbyqxmd.com/read/29407628/intraplatelet-reactive-oxygen-species-ros-correlate-with-the-shedding-of-adhesive-receptors-microvesiculation-and-platelet-adhesion-to-collagen-during-storage-does-endogenous-ros-generation-downregulate-platelet-adhesive-function
#14
Mehran Ghasemzadeh, Ehteramolsadat Hosseini, Zahra Oushyani Roudsari, Parvin Zadkhak
Platelets storage lesion is mainly orchestrated by platelet activating signals during storage. Reactive oxygen species (ROS) are being considered as important signaling molecules modulating platelet function while their production has also been shown to be augmented by platelet activation. This study investigated to what extent endogenous ROS generation during platelet storage could be correlated with platelet receptor shedding, microvesiculation and adhesive function. 10 PRP-platelet concentrates were subjected to flow cytometry analysis to examine the generation of intraplatelet ROS on days 1, 5 and 7 after storage...
March 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29345503/effectiveness-of-the-biophysical-barriers-to-the-peridural-fibrosis-in-rat-laminectomy-model
#15
Ibrahim Akkurt, Bulent Bakar, Gungor Cagdas Dincel, Fatma Azize Budak Yıldıran, Mustafa Ogden, Egemen Nursoy, Elif Sari
PURPOSE: Peridural fibrosis which could occur after the spinal surgery could adhere neural tissue closely and may cause to neural entrapment symptoms and require surgical reintervention. AIM OF THE STUDY: Present study was designed to reduce occurrence of peridural fibrosis in rat laminectomy model by using biophysical barriers called hyaluronic acid (HAS) dural barrier, activated polyethylene glycol and polyethylene imine (PEG) dural barrier, and platelet-rich plasma (PRP)...
January 18, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29316152/clinical-and-immunohistochemical-comparative-study-of-the-efficacy-of-carboxytherapy-vs-platelet-rich-plasma-in-treatment-of-stretch-marks
#16
Abeer A Hodeib, Ghada F R Hassan, Marwa N M Ragab, Eiman A Hasby
BACKGROUND: Striae distensae are dermal scars with a linear atrophic depression. The exact origin of striae distensae remains unrevealed, but low expression of collagen and fibronectin genes in the affected tissue was found. Several treatment modalities have been proposed, yet no consistent modality is available. AIM OF THE WORK: To evaluate and compare the efficacy and safety of carboxytherapy vs platelet-rich plasma (PRP) in treatment of stretch marks. PATIENTS AND METHODS: This study included 20 patients with striae alba...
January 7, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29313321/the-matrix-synthesis-and-anti-inflammatory-effect-of-autologous-leukocyte-poor-platelet-rich-plasma-in-human-cartilage-explants
#17
Mario Simental-Mendía, Félix Vilchez-Cavazos, Rubén García-Garza, Jorge Lara-Arias, Roberto Montes-de-Oca-Luna, Salvador Said-Fernández, Herminia G Martínez-Rodríguez
OBJECTIVE: To determine the effects of autologous leukocyte-poor platelet-rich plasma (LP-PRP) on the expression of markers involved in cartilage-extracellular matrix production and inflammation in cartilage explants bearing osteoarthritis. MATERIALS AND METHODS: Cartilage explants and LP-PRP were obtained from 10 patients who underwent total knee arthroplasty. The explants were cultured in spinner flasks for 28 days in the presence of interleukin (IL)-1β and/or LP-PRP...
January 9, 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/29291543/platelet-rich-plasma-inhibits-wnt-%C3%AE-catenin-signaling-in-rabbit-cartilage-cells-activated-by-il-1%C3%AE
#18
Jian Wu, Ji-Feng Huang, Xing-Xing Qin, Feng Hu, Zhao-Fei Chen, Yong Zheng, Yan-Xi Liu, Xian-Hua Cai
OBJECTIVE: Platelet-rich plasma (PRP) has been reported to alleviate degenerative pathological damage to joint cartilage. This study aimed to investigate the effect of PRP on Wnt/β-catenin signaling in rabbit chondrocytes. METHODS: Using 3-month-old New Zealand white rabbits, PRP was prepared from venous blood, and chondrocytes were cultured from knee joint cartilage and identified by staining for type II collagen and proteoglycan. The effects of PRP on chondrocyte viability were measured...
February 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29240523/injectable-platelet-rich-fibrin-using-the-low-speed-centrifugation-concept-improves-cartilage-regeneration-when-compared-to-platelet-rich-plasma
#19
Mustafa Abd El Raouf, Xuzhu Wang, Si Miusi, Jihua Chai, Abdel Basit Mohamed AbdEl-Aal, Mekkawy M Nefissa Helmy, Shahram Ghanaati, Joseph Choukroun, Elisa Choukroun, Yufeng Zhang, Richard J Miron
The aim of the present study was to evaluate the effect of injectable platelet-rich fibrin (i-PRF) on cultivated chondrocytes and osteochondral regeneration in critical-sized osteochondral defect of the rabbit's knee in comparison to autologous platelet-rich plasma (PRP). Chondrocytes were first investigated for their ability to proliferate and differentiate in response to PRP and i-PRF. Thereafter, full-thickness critical-sized osteochondral defects 5 mm in diameter and 5 mm in depth were created in the knee joint of 12 adult female New Zealand White rabbits...
December 14, 2017: Platelets
https://www.readbyqxmd.com/read/29226987/protective-effect-of-platelet-rich-plasma-on-urethral-injury-model-of-male-rats
#20
Hasan H Tavukcu, Ömer Aytaç, Fatih Atuğ, Burçin Alev, Özge Çevik, Nurdan Bülbül, Ayşen Yarat, Şule Çetinel, Göksel Şener, Haluk Kulaksızoğlu
AIMS: Urethral stricture (US) formation is caused by fibrosis after excessive collagen formation following an injury or trauma to the urethra. In this study, we aimed to evaluate the effects of platelet-rich plasma (PRP) on a urethral injury (UI) model of male rats. METHODS: A UI model was used by applying a coagulation current to the urethras of male rats. There were four groups with six rats in each: control group, PRP applied to naive urethra, UI group, and UI with PRP application...
December 11, 2017: Neurourology and Urodynamics
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