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Collagen AND PRP

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https://www.readbyqxmd.com/read/29345503/effectiveness-of-the-biophysical-barriers-to-the-peridural-fibrosis-in-rat-laminectomy-model
#1
Ibrahim Akkurt, Bulent Bakar, Gungor Cagdas Dincel, Fatma Azize Budak Yıldıran, Mustafa Ogden, Egemen Nursoy, Elif Sari
PURPOSE: Peridural fibrosis which could occur after the spinal surgery could adhere neural tissue closely and may cause to neural entrapment symptoms and require surgical reintervention. AIM OF THE STUDY: Present study was designed to reduce occurrence of peridural fibrosis in rat laminectomy model by using biophysical barriers called hyaluronic acid (HAS) dural barrier, activated polyethylene glycol and polyethylene imine (PEG) dural barrier, and platelet-rich plasma (PRP)...
January 18, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29316152/clinical-and-immunohistochemical-comparative-study-of-the-efficacy-of-carboxytherapy-vs-platelet-rich-plasma-in-treatment-of-stretch-marks
#2
Abeer A Hodeib, Ghada F R Hassan, Marwa N M Ragab, Eiman A Hasby
BACKGROUND: Striae distensae are dermal scars with a linear atrophic depression. The exact origin of striae distensae remains unrevealed, but low expression of collagen and fibronectin genes in the affected tissue was found. Several treatment modalities have been proposed, yet no consistent modality is available. AIM OF THE WORK: To evaluate and compare the efficacy and safety of carboxytherapy vs platelet-rich plasma (PRP) in treatment of stretch marks. PATIENTS AND METHODS: This study included 20 patients with striae alba...
January 7, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29313321/the-matrix-synthesis-and-anti-inflammatory-effect-of-autologous-leukocyte-poor-platelet-rich-plasma-in-human-cartilage-explants
#3
Mario Simental-Mendía, Félix Vilchez-Cavazos, Rubén García-Garza, Jorge Lara-Arias, Roberto Montes-de-Oca-Luna, Salvador Said-Fernández, Herminia G Martínez-Rodríguez
OBJECTIVE: To determine the effects of autologous leukocyte-poor platelet-rich plasma (LP-PRP) on the expression of markers involved in cartilage-extracellular matrix production and inflammation in cartilage explants bearing osteoarthritis. MATERIALS AND METHODS: Cartilage explants and LP-PRP were obtained from 10 patients who underwent total knee arthroplasty. The explants were cultured in spinner flasks for 28 days in the presence of interleukin (IL)-1β and/or LP-PRP...
January 9, 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/29291543/platelet-rich-plasma-inhibits-wnt-%C3%AE-catenin-signaling-in-rabbit-cartilage-cells-activated-by-il-1%C3%AE
#4
Jian Wu, Ji-Feng Huang, Xing-Xing Qin, Feng Hu, Zhao-Fei Chen, Yong Zheng, Yan-Xi Liu, Xian-Hua Cai
OBJECTIVE: Platelet-rich plasma (PRP) has been reported to alleviate degenerative pathological damage to joint cartilage. This study aimed to investigate the effect of PRP on Wnt/β-catenin signaling in rabbit chondrocytes. METHODS: Using 3-month-old New Zealand white rabbits, PRP was prepared from venous blood, and chondrocytes were cultured from knee joint cartilage and identified by staining for type II collagen and proteoglycan. The effects of PRP on chondrocyte viability were measured...
December 29, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29240523/injectable-platelet-rich-fibrin-using-the-low-speed-centrifugation-concept-improves-cartilage-regeneration-when-compared-to-platelet-rich-plasma
#5
Mustafa Abd El Raouf, Xuzhu Wang, Si Miusi, Jihua Chai, Abdel Basit Mohamed AbdEl-Aal, Mekkawy M Nefissa Helmy, Shahram Ghanaati, Joseph Choukroun, Elisa Choukroun, Yufeng Zhang, Richard J Miron
The aim of the present study was to evaluate the effect of injectable platelet-rich fibrin (i-PRF) on cultivated chondrocytes and osteochondral regeneration in critical-sized osteochondral defect of the rabbit's knee in comparison to autologous platelet-rich plasma (PRP). Chondrocytes were first investigated for their ability to proliferate and differentiate in response to PRP and i-PRF. Thereafter, full-thickness critical-sized osteochondral defects 5 mm in diameter and 5 mm in depth were created in the knee joint of 12 adult female New Zealand White rabbits...
December 14, 2017: Platelets
https://www.readbyqxmd.com/read/29226987/protective-effect-of-platelet-rich-plasma-on-urethral-injury-model-of-male-rats
#6
Hasan H Tavukcu, Ömer Aytaç, Fatih Atuğ, Burçin Alev, Özge Çevik, Nurdan Bülbül, Ayşen Yarat, Şule Çetinel, Göksel Şener, Haluk Kulaksızoğlu
AIMS: Urethral stricture (US) formation is caused by fibrosis after excessive collagen formation following an injury or trauma to the urethra. In this study, we aimed to evaluate the effects of platelet-rich plasma (PRP) on a urethral injury (UI) model of male rats. METHODS: A UI model was used by applying a coagulation current to the urethras of male rats. There were four groups with six rats in each: control group, PRP applied to naive urethra, UI group, and UI with PRP application...
December 11, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29226630/microneedling-combined-with-platelet-rich-plasma-or-trichloroacetic-acid-peeling-for-management-of-acne-scarring-a-split-face-clinical-and-histologic-comparison
#7
Moetaz El-Domyati, Hossam Abdel-Wahab, Aliaa Hossam
BACKGROUND: Minimally invasive procedures provide effective, safe, relatively long-lasting, and natural results without large damage to the skin. A combination treatment is considered an approach that includes at least 2 different and unrelated modalities. OBJECTIVES: This study aims to evaluate the use and effectiveness of some combined minimally invasive procedures for management of acne scarring. PATIENTS/METHODS: Twenty-four volunteers with postacne atrophic scars were randomly divided into 3 equal groups according to performed procedure on each side of the face (microneedling by dermaroller alone or combined with platelet-rich plasma [PRP] or trichloroacetic acid [TCA] 15% peeling) and received 6 bi-weekly sessions of treatment...
December 10, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29215443/scaffold-free-bone-regeneration-using-platelet-rich-fibrin-in-calvarial-defect-model
#8
Yeo Reum Jeon, Mi Jung Kim, Yong Oock Kim, Tai Suk Roh, Won Jai Lee, Eun Hye Kang, In Sik Yun
Bone regeneration is a complex process influenced by various physiological factors. Platelet-rich plasma (PRP) contains many growth factors and has shown osteogenic effects. The PRP is usually activated before use. However, the authors showed that nonactivated PRP (nPRP) and activated PRP have comparable osteogenic effects in the previous study. Generally, a scaffold has been needed for the application of PRP in the cranial defect model. In this study, the authors aimed to compare the performance of scaffold free platelet-rich fibrin (PRF) to nPRP as an adjuvant for bone regeneration...
December 6, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29211969/use-of-platelet-rich-plasma-immediately-after-an-injury-did-not-improve-ligament-healing-and-increasing-platelet-concentrations-was-detrimental-in-an-in-vivo-animal-model
#9
Robert F LaPrade, Laurie R Goodrich, Jennifer Phillips, Grant J Dornan, Travis Lee Turnbull, Michael L Hawes, Kimi D Dahl, Ashley N Coggins, John Kisiday, David Frisbie, Jorge Chahla
BACKGROUND: Limited information in basic science and clinical trials exists to determine if ligament healing may be accelerated with the use of biological adjuvants, such as platelet-rich plasma (PRP). However, there has been widespread acceptance of PRP for use in clinical practice, despite an inadequate understanding of its biological mechanism of action. PURPOSE: To determine whether a single dose of PRP could accelerate ligament healing and correspondingly improve histological characteristics and biomechanical properties when injected immediately postoperatively into the injured medial collateral ligament (MCL) of New Zealand White rabbits...
December 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29130636/efficacy-of-subcutaneous-injection-of-platelet-rich-plasma-in-alopecia-a-clinical-and-histological-pilot-study-on-a-rat-model-with-a-six-month-long-term-follow-up-experience
#10
Sophie Orliac, Jean-Michel Serfaty, Anne Perozziello, Olivier Zurlinden, Liliane Louedec, Benjamin Dallaudière
PURPOSE: To assess the potential of platelet-rich plasma (PRP) subcutaneous injection of to treat alopecia and to evaluate local toxicity. MATERIALS-METHODS: Twelve Hairless rats were used. At D0, we performed systematic clinical examination and divided the rat back into four quadrants (Q). We initiated subcutaneous injection using either PRP in PRPQ+, platelet-poor plasma (PPP) in PPPQ+, physiological serum (PS) in PSQ+, or no treatment (Q4). At D7, D14, D21, and D28 but also second month (M2), M3, M4, M5, rats had exactly the same injection procedure...
November 11, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29122407/three-dimensional-poly-lactic-co-glycolic-acid-scaffold-containing-autologous-platelet-rich-plasma-supports-keloid-fibroblast-growth-and-contributes-to-keloid-formation-in-a-nude-mouse-model
#11
Chunlin Chen, Haibin Wang, Guozhang Zhu, Zhongsheng Sun, Xiang Xu, Fangwei Li, Shengkang Luo
BACKGROUND: There is a lack of proper animal models to study keloid formation. AIM: To create three-dimensional poly lactic-co-glycolic acid (PLGA) scaffolds containing autologous platelet-rich plasma (PRP) as an in vitro culture environment for keloid fibroblasts (KL), and to study their implantation into nude mice to mimic the process of keloid formation. METHODS: Normal fibroblasts (FB) and KL cells were isolated from surgical specimens and transduced with lentivirus loaded with green fluorescent protein (GFP) and luciferase genes...
October 26, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29040421/effect-of-use-of-platelet-rich-plasma-prp-in-skin-with-intrinsic-aging-process
#12
Luiz Charles-de-Sá, Natale Ferreira Gontijo-de-Amorim, Christina Maeda Takiya, Radovan Borojevic, Donatella Benati, Paolo Bernardi, Andrea Sbarbati, Gino Rigotti
Background: In previous papers, we demonstrated that the treatment of human photoaged skin with stromal-vascular fraction-enriched fat or expanded adipose-derived stem cells showed a decrease of elastosis and the appearance of new oxytalan elastic fibers in dermis and an increase in the vascular network. The utilization of fat plus platelet-rich plasma (PRP) led to an increase in the vascular permeability and reactivity of the nervous component. Objectives: The purpose of this study was to analyze the histologic and ultrastructural changes of human skin after the injection of only PRP in the retroauricular area that was not exposed to sun and did not present the photoaging process, in comparison with our previous results...
September 7, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29026811/the-use-of-platelet-rich-plasma-for-storage-of-surplus-harvested-skin-grafts
#13
Ilknur Keskin, Nilufer Ayturk, Mustafa Sutcu, Mustafa Keskin, Tangul Mudok
BACKGROUND: There is a need for improved methods and storage media to sustain the tissue viability of autologous skin grafts. OBJECTIVE: To compare histological changes in human skin grafts stored in platelet-rich plasma (PRP) with those of grafts stored in saline. METHODS: Eight circular, 3-mm full-thickness skin graft samples were harvested from the abdominal skin of each of 5 patients scheduled to undergo an abdominoplasty procedure. Four of these graft samples were stored in saline, and the other 4 were stored in saline mixed with PRP prepared from the patient's own venous blood...
February 2017: Plastic Surgery
https://www.readbyqxmd.com/read/29022492/platelet-aggregation-impacts-thrombin-generation-assessed-by-calibrated-automated-thrombography
#14
Mélusine Didelot, Clémence Docq, Denis Wahl, Patrick Lacolley, Véronique Regnault, Jérémy Lagrange
A calibrated automated thrombogram (CAT) is performed usually with human platelet-free plasma (PFP) but may be more relevant with platelet-rich plasma (PRP). In this case, platelets are not stimulated by subendothelial molecules like collagen. Our aim was to assess the consequence of strong (collagen) or weak (ADP) induction of platelet release and aggregation on thrombin generation. Platelet aggregation in PRP was triggered with 10 µg/mL collagen or 10 µM ADP using a lumi-aggregometer. Thrombin generation curves were monitored by CAT in different conditions: PRP, PRP with activated platelets (actPRP), aggregated PRP (agPRP), aggregated platelets resuspended in autologous PFP (resPRP), PFP and PFP obtained after aggregation (agPFP)...
October 12, 2017: Platelets
https://www.readbyqxmd.com/read/28981200/soluble-fibrin-causes-an-acquired-platelet-glycoprotein-vi-signaling-defect-implications-for-coagulopathy
#15
M Y Lee, C C Verni, B A Herbig, S L Diamond
Essentials Collagen and thrombin when used simultaneously generate highly activated platelets. The effect of thrombin stimulation on subsequent glycoprotein VI (GPVI) function was observed. Soluble fibrin, but not protease activated receptor (PAR) activation, prevented GPVI activation. Circulating soluble fibrin in coagulopathic blood may cause an acquired GPVI signaling defect. SUMMARY: Background In coagulopathic blood, circulating thrombin may drive platelet dysfunction. Methods/Results Using calcium dye-loaded platelets, the effect of thrombin exposure and soluble fibrin generation on subsequent platelet GPVI function was investigated...
December 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28967470/involvement-of-synovial-matrix-degradation-and-angiogenesis-in-oxidative-stress-exposed-degenerative-rotator-cuff-tears-with-osteoarthritis
#16
Kyu-Cheol Noh, Sin-Hye Park, Cheol Jung Yang, Geun Woo Lee, Min Ki Kim, Young-Hee Kang
BACKGROUND: Shoulder osteoarthritis is a gradual wearing of the articular cartilage concomitant with degenerative rotator cuff tears (RCTs). This pathologic disorder is related to inflammation, oxidative stress, and angiogenesis. Degenerative alterations may prompt production of cytokines and angiogenesis-related proteins, evoking rotator cuff diseases. This study tested the hypothesis that oxidative stress-responsive mediators can influence joint inflammation of patients with RCT. METHODS: Twelve healthy RCT patients not suffering shoulder osteoarthritis were categorized as the control group, and 24 patients were allocated to 2 RCT groups (RCTP1 and RCTP2), according to severity of RCT and glenohumeral arthritis...
January 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28960933/autologous-bioscaffolds-based-on-different-concentrations-of-platelet-rich-plasma-and-synovial-fluid-as-a-vehicle-for-mesenchymal-stem-cells
#17
Ane Garate, Pello Sánchez, Diego Delgado, Ane Miren Bilbao, Emma Muiños-López, Froilán Granero-Moltó, Gorka Orive, Felipe Prosper, José Luis Pedraz, Mikel Sánchez
In the field of tissue engineering, diverse types of bioscaffolds are being developed currently for osteochondral defect applications. In this work, a novel scaffold based on platelet rich plasma (PRP) and hyaluronic acid with mesenchymal stem cells (MSCs) has been evaluated to observe its effect on immobilized cells. The bioscaffolds were prepared by mixing different volumes of synovial fluid (SF) with PRP from patients obtaining three formulations at PRP-SF ratios of 3:1, 1:1 and 1:3 (v/v). The live/dead staining revealed that although the cell number of each type of bioscaffold was different, these this constructs provide cells with a suitable environment for their viability and proliferation...
September 27, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28960123/assessment-of-platelet-function-on-the-routine-coagulation-analyzer-sysmex-cs-2000i
#18
Corinne Frère, Katsushi Kobayashi, Claire Dunois, Jean Amiral, Pierre-Emmanuel Morange, Marie-Christine Alessi
BACKGROUND: Light transmission aggregometry (LTA) is considered as the gold standard for testing platelet function in the setting of both platelet disorders suspicion and response to antiplatelet therapy evaluation. LTA requires however specialized equipment, substantial blood sample volumes, is technically challenging and time-consuming. AIM: To evaluate an automated platelet aggregation method performed on a routine coagulation analyzer Sysmex CS-2000i. METHODS: 46 patients presenting a bleeding syndrome and 62 patients with acute coronary syndrome receiving dual antiplatelet therapy were studied in total...
September 29, 2017: Platelets
https://www.readbyqxmd.com/read/28886194/a-new-rabbit-model-of-impaired-wound-healing-in-an-x-ray-irradiated-field
#19
Kazutoshi Fujita, Soh Nishimoto, Toshihiro Fujiwara, Yohei Sotsuka, Maki Tonooka, Kenichiro Kawai, Masao Kakibuchi
Radiation is an important therapy for cancer with many benefits; however, its side effects, such as impaired wound healing, are a major problem. While many attempts have been made to overcome this particular disadvantage, there are few effective treatments for impaired wound healing in an X-ray-irradiated field. One reason for this deficiency is the lack of experimental models, especially animal models. We have previously reported a mouse model of impaired wound healing in which the irradiation area was restricted to the hindlimbs...
2017: PloS One
https://www.readbyqxmd.com/read/28806294/the-tissue-engineered-tendon-bone-interface-in-vitro-and-in-vivo-synergistic-effects-of-adipo-derived-stem-cells-platelet-rich-plasma-and-extracellular-matrix-hydrogel
#20
Rory McGoldrick, Arhana Chattopadhyay, Christopher Crowe, Grace Chiou, Kenneth Hui, Simon Farnebo, Christopher Davis, Anais Le Grand, Molly Jacobs, Hung Pham, James Chang
INTRODUCTION: Suboptimal healing of the tendon bone interface (TBI) remains an unsolved problem. One solution is a biocompatible tissue engineered construct that promotes augmented healing. We hypothesisze that 1.) the presence of Platelet Rich Plasma (PRP) and prolonged in vitro incubation produces tissue engineered tendon bone interface scaffolds with greater reseeding of viable Adipo-derived Stem Cells (ADSC) and 2.) when implanted with extracellular matrix hydrogel, constructs will display superior in vivo strength repair and biocompatibility...
August 3, 2017: Plastic and Reconstructive Surgery
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