Jennifer Nash, Samuel Debono, Beth Whittington, Jakub Kaczynski, Tim Clark, Gillian Macnaught, Scott Semple, Edwin J R van Beek, Adriana Tavares, Damini Dey, Michelle C Williams, Piotr J Slomka, David E Newby, Marc R Dweck, Alexander J Fletcher
INTRODUCTION: Non-invasive detection of pathological changes in thoracic aortic disease remains an unmet clinical need particularly for patients with congenital heart disease. Positron emission tomography combined with magnetic resonance imaging (PET-MRI) could provide a valuable low-radiation method of aortic surveillance in high-risk groups. Quantification of aortic microcalcification activity using sodium [18 F]fluoride holds promise in the assessment of thoracic aortopathies. We sought to evaluate aortic sodium [18 F]fluoride uptake in PET-MRI using three methods of attenuation correction compared to positron emission tomography computed tomography (PET-CT) in patients with bicuspid aortic valve, METHODS: Thirty asymptomatic patients under surveillance for bicuspid aortic valve disease underwent sodium [18 F]fluoride PET-CT and PET-MRI of the ascending thoracic aorta during a single visit...
March 8, 2024: European Journal of Nuclear Medicine and Molecular Imaging