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Elżbieta Łuczyńska, Joanna Niemiec, Edward Hendrick, Sylwia Heinze, Janusz Jaszczyński, Jerzy Jakubowicz, Beata Sas-Korczyńska, Janusz Rys
BACKGROUND Contrast enhanced spectral mammography (CESM) is a new method of breast cancer diagnosis in which an iodinated contrast agent is injected and dual-energy mammography is obtained in multiple views of the breasts. The aim of this study was to compare the degree of enhancement on CESM with lesion characteristics on mammography (MG) and lesion histology in women with suspicious breast lesions. MATERIAL AND METHODS The degree of enhancement on CESM (absent, weak, medium, or strong) was compared to lesion characteristics on MG (mass, mass with microcalcifications, or microcalcifications alone) and histology (infiltrating carcinoma, intraductal carcinoma, or benign) to compare sensitivity of the two modalities and to establish correlations that might improve diagnostic accuracy...
October 21, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Fang-Fei Wei, Nadja E A Drummen, Lutgarde Thijs, Lotte Jacobs, Marjolein Herfs, Cynthia Van't Hoofd, Cees Vermeer, Jan A Staessen
Vitamin-K-dependent carboxylation of matrix Gla protein (MGP) protects the macrocirculation against calcification. We recently reported in a multiethnic population study that the estimated glomerular filtration rate, a microvascular trait, decreased and the risk of chronic kidney disease increased with higher circulating levels of inactive dephospho-uncarboxylated MGP, a marker of vitamin K deficiency. These findings highlighted the possibility that vitamin K might have a beneficial effect on the renal microcirculation...
September 2016: Pulse (Basel, Switzerland)
Matthew E Brice, Marisa Gossweiler, Larry Bennett
Artifacts are universal across all imaging modalities, varying in their conspicuity and significance. In this report three patients with pathology-proven breast cancer who had densities masquerading as microcalcifications at the resection margins of the lumpectomy specimens, but had negative microscopic margins, will be discussed. It was determined that these pseudocalcifications were the result of ink precipitates from a commonly utilized tissue marking dye. This artifact was further evaluated and reproduced by utilizing a boneless chicken breast as a phantom...
October 13, 2016: Radiology
Antonio Sarno, Giovanni Mettivier, Francesca Di Lillo, Mario Cesarelli, Paolo Bifulco, Paolo Russo
We developed a scanner for micro computed tomography dedicated to the breast (BµCT) with a high resolution flat-panel detector and a microfocus X-ray tube. We evaluated the system spatial resolution via the 3D modulation transfer function (MTF). In addition to conventional absorption-based X-ray imaging, such a prototype showed capabilities for propagation-based phase-contrast and related edge enhancement effects in 3D imaging. The system limiting spatial resolution is 6.2mm(-1) (MTF at 10%) in the vertical direction and 3...
October 7, 2016: Medical Engineering & Physics
Bo Li, Yaqiong Zhang, Ping Yin, Jian Zhou, Tian'an Jiang
The present study aimed to investigate the value of ultrasonography in the diagnosis of papillary thyroid microcarcinoma (PTMC) coexisting with a thyroid abnormality, and to improve the accuracy of PTMC diagnosis. The ultrasonic features of 38 PTMC nodules coexisting with a thyroid abnormality and 56 thyroid benign nodules, obtained by surgical resection and confirmed by pathological analysis, were retrospectively analyzed. All masses were ≤ 1.0 cm in diameter. Ultrasonic features that were analyzed included the shape, aspect ratio, boundary, margin, echo, uniformity, presence or absence of microcalcification and enlargement of the lymph nodes, as well as the blood flow of the nodules...
October 2016: Oncology Letters
Weijia Lu, Bruno Haider
BACKGROUND AND PURPOSE: The twinkling sign in B-flow imaging (BFI-TS) has been reported in the literature to increase both specificity and sensitivity compared to the traditional gray-scale imaging. Unfortunately, there has been no conclusive study on the mechanism of this effect. METHODS: In the study presented here, a comparative test on phantoms is introduced, where the variance of a phase estimator is used to quantify the motion amplitude. The statistical inference is employed later to find the dominate factor for the twinkling sign, which is proven by computer simulation...
September 29, 2016: Journal of Medical Ultrasonics
Jun Wei Zhang, Zhao Jin Chen, Anil Gopinathan
INTRODUCTION: Hashimoto's thyroiditis (HT) can present as focal nodular disease. This study aimed to determine the distinguishing sonographic features of nodules in biopsy-proven focal HT. MATERIALS AND METHODS: The study included 388 thyroid nodules from 310 patients who underwent ultrasound-guided fine-needle aspiration biopsy (FNAB). There were 28 focal HT, 27 malignant and 333 other benign nodules. Sonographic features of focal HT nodules on prebiopsy ultrasound were compared with malignant nodules and other benign nodules using multinomial logistic regression adjusting for the correlation between multiple nodules obtained from the same patient...
August 2016: Annals of the Academy of Medicine, Singapore
Nicole Berger, Sibylle Dubach Schwizer, Zsuzsanna Varga, Christoph Rageth, Thomas Frauenfelder, Andreas Boss
OBJECTIVES: The objective was to determine if digital tomosynthesis of the breast (DBT) assesses the extension of ductal carcinoma in situ (DCIS) with higher precision than mammography (MG). MATERIAL AND METHODS: The local ethics committee approved this retrospective study including 26 patients with DCIS, which were rated by three radiologists. Statistics were performed using intraclass correlation (ICC) for interreader agreement and the Pearson correlation for correlation of MG and DBT...
September 13, 2016: Clinical Imaging
S C Hawkins, I Brown, P King, M El-Gammal, K Stepp, S Widdison, M Barta, N Jackson, P Drew
INTRODUCTION: Wire guided localisation (WGL) is the standard localisation technique for impalpable breast lesions. Radio-guided occult lesion localisation (ROLL) has been proposed as an alternative. We have been performing ROLL for therapeutic wide local excisions (WLE) and diagnostic excision biopsies (DEB) for the last 15 years. We present the largest reported consecutive series of ROLL excisions to date. PATIENTS AND METHODS: One thousand thirty nine consecutive patients who underwent ROLL for impalpable breast lesions were identified from a prospectively collected database...
September 9, 2016: European Journal of Surgical Oncology
Gustavo Machado Badan, Sebastião Piato, Décio Roveda, Eduardo de Faria Castro Fleury
PURPOSE: The purpose of this study was to evaluate BI-RADS indicators in the detection of DCIS by MRI. MATERIALS AND METHODS: Prospective observational study that started in 2014 and lasted 24 months. A total of 110 consecutive patients were evaluated, who presented with suspicious or highly suspicious microcalcifications on screening mammography (BI-RADS categories 4 and 5) and underwent stereotactic-guided breast biopsy, having had an MRI scan performed prior to biopsy...
October 2016: European Journal of Radiology
D M Layfield, H See, M Stahnke, L Hayward, R I Cutress, R S Oeppen
INTRODUCTION Ductal carcinoma in situ (DCIS) usually manifests as microcalcification on mammography but may be uncalcified. Consequently, a quarter of patients undergoing excision of a presumed pure DCIS require further surgery to re-excise margins. Patients at highest risk of margin involvement may benefit from additional preoperative assessment. METHODS A retrospective review was carried out of patients treated for screen detected, biopsy proven DCIS in a single centre over a ten-year period (1999-2009). Logistic regression analysis identified factors predictive of need for further surgery to clear margins...
September 23, 2016: Annals of the Royal College of Surgeons of England
Ravi K Samala, Heang-Ping Chan, Lubomir M Hadjiiski, Mark A Helvie
With IRB approval, digital breast tomosynthesis (DBT) images of human subjects were collected using a GE GEN2 DBT prototype system. Corresponding digital mammograms (DMs) of the same subjects were collected retrospectively from patient files. The data set contained a total of 237 views of DBT and equal number of DM views from 120 human subjects, each included 163 views with microcalcification clusters (MCs) and 74 views without MCs. The data set was separated into training and independent test sets. The pre-processing, object prescreening and segmentation, false positive reduction and clustering strategies for MC detection by three computer-aided detection (CADe) systems designed for DM, DBT, and a planar projection image generated from DBT were analyzed...
October 7, 2016: Physics in Medicine and Biology
Louise Wilkinson, Val Thomas, Nisha Sharma
This article discusses the significance of microcalcifications on mammography and the changes in technology that have influenced management; it also describes a pragmatic approach to investigation of microcalcification in a UK screening programme.
October 17, 2016: British Journal of Radiology
Hongjun Li, Shanhua Zhang, Qingyuan Wang, Rongguang Zhu
OBJECTIVE: To study the effect and clinical value of mammography in the diagnosis of breast lump so as to improve the diagnosis level of breast cancer. METHODS: A retrospective analysis was carried out on clinical data of 110 patients with mammary lump confirmed by pathology to study the compliance of mammography diagnosis and Pathology diagnosis in breast lump, and the detection of microcalcifications, phyllode, and observe the image performance of mammography...
July 2016: Pakistan Journal of Medical Sciences Quarterly
Miyuki Kanematsu, Masami Morimoto, Masako Takahashi, Junko Honda, Yoshimi Bando, Takuya Moriya, Yukiko Tadokoro, Misako Nakagawa, Hirokazu Takechi, Takahiro Yoshida, Hiroaki Toba, Mitsuteru Yoshida, Aiichiro Kajikawa, Akira Tangoku, Issei Imoto, Mitsunori Sasa
Background Overdiagnosis in mammography (MMG) is a problem. Combination of MMG and ultrasonography for breast cancer screening may increase overdiagnosis. Most cases of overdiagnosis are low-grade ductal carcinoma in situ (LGD), but no reports have focused on them. Materials and methods We immunostained 169 ductal carcinoma in situ (DCIS) cases for ER, PgR, HER2 and Ki67 and classified them into 4 subtypes: ER(+)/HER2(-), ER(+)/HER2(+), ER(-)/HER2(-) and ER(-)/HER2(+). The Ki67 index was used to evaluate the grade of malignancy and examined for correlations with each ER/HER2 subtype and the nuclear grade (NG), with/without comedo necrosis...
2016: Journal of Medical Investigation: JMI
Maria Vernet-Tomas, Sergi Mojal, Rocío Gamero, Pau Nicolau, Ana Rodríguez-Arana, Francisco Plancarte, Josep M Corominas, Laia Serrano-Munne, Ramon Carreras, Dolors Sabadell
BACKGROUND: The aim of our study was to establish which clinical, radiologic and pathologic factors could predict the risk of under- and overestimation of the breast ductal carcinoma in situ (DCIS) size when preoperatively measuring the maximum mammographic extent of microcalcifications (MEM). METHODS: We made a retrospective review of patients with a DCIS treated in our Breast Unit between May 2005 and May 2012. Clinical, pathologic and radiologic data were evaluated as possible predictive factors for over- or underestimation of DCIS size when measuring MEM...
September 17, 2016: Breast Cancer: the Journal of the Japanese Breast Cancer Society
Maria Pané Foix, Ana Dunatov, Petr Martinek, Enric Condom Mundó, Saul Suster, Maris Sperga, Jose I Lopez, Monika Ulamec, Stela Bulimbasic, Delia Perez Montiel, Reza Alaghehbandan, Kvetoslava Peckova, Krystina Pivovarcikova, Daum Ondrej, Pavla Rotterova, Faruk Skenderi, Kristyna Prochazkova, Martin Dusek, Milan Hora, Michal Michal, Ondrej Hes
Chromophobe renal cell carcinoma (ChRCC) is typically composed of large leaf-like cells and smaller eosinophilic cells arranged in a solid-alveolar pattern. Eosinophilic, adenomatoid/pigmented, or neuroendocrine variants have also been described. We collected 10 cases of ChRCC with a distinct multicystic pattern out of 733 ChRCCs from our registry, and subsequently analyzed these by morphology, immunohistochemistry, and array comparative genomic hybridization. Of the 10 patients, 6 were males with an age range of 50-89 years (mean 68, median 69)...
September 15, 2016: Virchows Archiv: An International Journal of Pathology
Katarzyna Dobruch-Sobczak, Elwira Bakuła Zalewska, Anna Gumińska, Rafał Zenon Słapa, Krzysztof Mlosek, Paweł Wareluk, Wiesław Jakubowski, Marek Dedecjus
The aims of our study were to determine whether shear wave elastography (SWE) can improve the conventional B-mode differentiation of thyroid lesions, determine the most accurate SWE parameter for differentiation and assess the influence of microcalcifications and chronic autoimmune thyroiditis on SWE values. We examined 119 patients with 169 thyroid nodules who prospectively underwent B-mode ultrasound and SWE using the same ultrasound machine. The parameters assessed using SWE were: mean elasticity within the entire lesion (SWE-whole) and mean (SWE-mean) and maximum (SWE-max) elasticity for a 2-mm-diameter region of interest in the stiffest portion of the lesion, excluding microcalcifications...
September 9, 2016: Ultrasound in Medicine & Biology
Yolanda Cifuentes, Martha Isabel Murcia, Jorge Piar, Patricia Pardo
Tuberculosis is a serious public health problem worldwide. In 2012, the World Health Organization estimated 8.6 million new cases and 1.3 million deaths due to the disease. In 2011, the incidence in Colombia was 24 cases per 100,000 inhabitants. There is little information about tuberculosis in pregnant women, and congenital infection is considered a rare disease that is difficult to diagnose, leads to high mortality, and may be confused with tuberculosis acquired after birth. In addition, it has been associated with HIV infection in mothers and infants...
2016: Biomédica: Revista del Instituto Nacional de Salud
Pierluigi Rinaldi, Chiara Buccheri, Michela Giuliani, Enida Bufi, Maurizio Romani, Federica Patrolecco, Paolo Belli, Lorenzo Bonomo
PURPOSE: This study aims to investigate sensitivity of breast magnetic resonance imaging (MRI) for mammographic microcalcifications-only ductal carcinoma in situ (DCIS), based on its histopathology and mammographic extent of microcalcifications. METHODS: Mammograms were reviewed to measure the extent of microcalcifications. Sensitivity of MRI was calculated in the overall study population and in groups differing for DCIS nuclear grade, microinvasivity, and microcalcifications' extent...
August 6, 2016: Clinical Imaging
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