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Microcalcifications

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https://www.readbyqxmd.com/read/28628656/ultrasound-guided-cable-free-13-gauge-vacuum-assisted-biopsy-of-non-mass-breast-lesions
#1
Jiwoon Seo, Sun Mi Kim, Mijung Jang, Bo La Yun, Soo Hyun Lee, Eun-Kyu Kim, Eunyoung Kang, So Yeon Park, Woo Kyung Moon, Hye Young Choi, Bohyoung Kim
PURPOSE: To compare the outcomes of ultrasound-guided core biopsy for non-mass breast lesions by the novel 13-gauge cable-free vacuum-assisted biopsy (VAB) and by the conventional 14-gauge semi-automated core needle biopsy (CCNB). MATERIALS AND METHODS: Our institutional review board approved this prospective study, and all patients provided written informed consent. Among 1840 ultrasound-guided percutaneous biopsies performed from August 2013 to December 2014, 145 non-mass breast lesions with suspicious microcalcifications on mammography or corresponding magnetic resonance imaging finding were subjected to 13-gauge VAB or 14-gauge CCNB...
2017: PloS One
https://www.readbyqxmd.com/read/28623687/microcalcifications-in-stone-obstructed-human-submandibular-gland-are-associated-with-apoptosis-and-cell-proliferation
#2
Ivan Lau, Ajay Potluri, Cliff-Lawrence Ibeh, Robert S Redman, Edina Paal, Bidhan C Bandyopadhyay
OBJECTIVE: Human submandibular gland (SMG) stones are associated with inflammation, fibrosis and microcalcifications in the surrounding tissues. However, there is little information about the accompanying cell injury-repair process, apoptosis, and cell proliferation. The purpose of this study was to investigate such an association and its clinical significance. DESIGN OF STUDY: Mid-gland paraffin sections of human SMGs ("stone glands") and normal SMGs ("non-stone glands") were subjected to stains for general histology (hematoxylin and eosin), fibrosis (Masson's trichrome), and calcification (alizarin red) and to immunohistochemistry for proliferative activity (Ki-67), and apoptosis (Caspase-3)...
June 7, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28618103/secretory-pathway-ca-2-atpases-promote-in-vitro-microcalcifications-in-breast-cancer-cells
#3
Donna Dang, Hari Prasad, Rajini Rao
Calcification of the breast is often an outward manifestation of underlying molecular changes that drive carcinogenesis. Up to 50% of all non-palpable breast tumors and 90% of ductal carcinoma in situ present with radiographically dense mineralization in mammographic scans. However, surprisingly little is known about the molecular pathways that lead to microcalcifications in the breast. Here, we report on a rapid and quantitative in vitro assay to monitor microcalcifications in breast cancer cell lines, including MCF7, MDA-MB-231 and Hs578T...
June 15, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28597716/postmortem-whole-exome-sequencing-identifies-novel-eif2b3-mutation-with-prenatal-phenotype-in-2-siblings
#4
Hannah Song, Sina Haeri, Hannes Vogel, Marjo van der Knaap, Keith Van Haren
OBJECTIVE: We describe 2 male siblings with a severe, prenatal phenotype of vanishing white matter disease and the impact of whole exome sequencing on their diagnosis and clinical care. METHODS: The 2 children underwent detailed clinical characterization, through clinical and laboratory testing, as well as prenatal and postnatal imaging. Biobanked blood from the 2 siblings was submitted for whole exome sequencing at Baylor Laboratories. RESULTS: Both male children had abnormal prenatal neuroimaging and suffered precipitous, fatal neurologic decline...
January 1, 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/28582921/grouped-fuzzy-svm-with-em-based-partition-of-sample-space-for-clustered-microcalcification-detection
#5
Huiya Wang, Jun Feng, Hongyu Wang
BACKGROUND: Detection of clustered microcalcification (MC) from mammograms plays essential roles in computer-aided diagnosis for early stage breast cancer. OBJECTIVE: To tackle problems associated with the diversity of data structures of MC lesions and the variability of normal breast tissues, multi-pattern sample space learning is required. METHODS: In this paper, a novel grouped fuzzy Support Vector Machine (SVM) algorithm with sample space partition based on Expectation-Maximization (EM) (called G-FSVM) is proposed for clustered MC detection...
May 26, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/28570750/epithelial-mesenchymal-transition-inducer-snail1-and-invasive-potential-of-intraductal-breast-cancer
#6
Bartlomiej Szynglarewicz, Piotr Kasprzak, Piotr Donizy, Przemyslaw Biecek, Agnieszka Halon, Rafal Matkowski
BACKGROUND AND OBJECTIVES: Transcription factor Snail1 is a key inducer of epithelial-mesenchymal transition (EMT), a biological process implicated in the cancer progression and metastasis. The aim of the study was to investigate Snail1 expression in DCIS found on breast biopsy and assess its predictive value for the final invasion. METHODS: A total of 209 patients with histologically diagnosed pure DCIS entered the study. Snail1 reactivity was evaluated with immunohistochemistry in tumor tissue from stereotactic vacuum-assisted biopsy of suspicious microcalcifications...
June 1, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28553189/the-role-of-bone-scintigraphy-with-single-photon-emission-computed-tomography-computed-tomography-in-the-diagnosis-and-evaluation-of-calciphylaxis
#7
Patrick Martineau, Matthieu Pelletier-Galarneau, Sadri Bazarjani
Calciphylaxis, also known as calcific uremic arteriolopathy, is an uncommon disease, typically found in patients with the end-stage renal disease. Pathophysiological features include small vessel vasculopathy with mural calcification, fibrosis, and thrombosis. The clinical presentation varies but often consists of the necrosis of skin and subcutaneous tissues, with or without visceral organ involvement due to small vessel vasculopathy. This condition has a significant morbidity and mortality, making accurate diagnosis imperative...
April 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28549004/efficiency-of-b-mode-ultrasound-and-strain-elastography-in-differentiating-between-benign-and-malignant-cervical-lymph-nodes
#8
Eser Tugut, Cetin Celenk, Asli Tanrivermis Sayit, Tümay Bekci, Hediye Pinar Gunbey, Kerim Arslan
PURPOSE: The purpose of this study was to evaluate the diagnostic accuracy and efficiency of ultrasonography (US), especially when combined with strain elastography (SE), in differentiating between benign and malignant cervical lymph nodes (LNs). METHODS: Forty-one LNs were examined by B-mode US, power Doppler US, and SE. The following imaging features were analyzed: shape, echogenicity, echogenic hilum, calcification, intranodal vascular pattern, elasticity scores (5 categories), and strain ratio...
May 25, 2017: Ultrasound Quarterly
https://www.readbyqxmd.com/read/28534354/the-value-of-stereotactic-vacuum-assisted-breast-biopsy-in-the-investigation-of-microcalcifications-a-six-year-experience-with-853-patients
#9
Panagiotis M Safioleas, Dimitra Koulocheri, Nikolaos Michalopoulos, Paraskevi Liacou, Ioannis Flessas, Afroditi Nonni, Konstantinos Kontzoglou, George C Zografos
PURPOSE: Vacuum Assisted Breast Biopsy (VABB) is a minimal invasive technique, in the diagnostic approach for non palpable lesions. The aim of this study was to evaluate the efficacy and accuracy of VABB in the investigation of breast microcalcifications, a significant mammographic sign of early breast cancer. The rate of histological underestimation and the false negative rate were assessed based on the follow up data and the histological examination of the surgical specimens. METHODS: From January 2005 to November 2011, 853 women with mammographically detected microcalcifications, classified as BI-RADS 3-5, were referred to our Breast Unit for evaluation...
March 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28526187/chemotherapy-may-eradicate-ductal-carcinoma-in-situ-dcis-but-not-the-associated-microcalcifications
#10
H Goldberg, J Zandbank, V Kent, M Leonov-Polak, A Livoff, A Chernihovsky, M Guindy, E Evron
INTRODUCTION: We studied the effect of neoadjuvant chemotherapy (NAC) ± trastuzumab on the ductal carcinoma in situ (DCIS) component in patients with locally advanced breast cancer who achieved pathological complete response (pCR). METHODS: The diagnostic biopsies of 92 consecutive breast cancer patients that were treated with neoadjuvant chemotherapy (NAC) ± trastuzumab were evaluated for the presence of DCIS. Upon completion of NAC, the surgical specimens were evaluated for complete eradication of both the invasive and non-invasive cancer in the breast...
May 4, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28523326/hashimoto-s-thyroiditis-associated-with-thyroid-adenoma-with-h%C3%A3-rthle-cells-case-report
#11
Mihaela Stanciu, Liana Gabriela Bera, Mihaela Popescu, Florin Grosu, Florina Ligia Popa
Chronic thyroiditis may present a focal lesion, often-palpable abnormality, simulating nodular disease. The number and morphology of the Hürthle cells (HC) vary in the thyroid aspirate. Distinguishing between neoplastic and non-neoplastic HC lesions is difficult when using the fine-needle aspiration cytology (FNAC). We present the case of a 46-year-old female with a large right nodular goiter and hypothyroidism and high titer of anti-thyroid peroxidase antibody (TPO). The thyroid ultrasound showed a large well-defined nodule (more than 6...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28512732/decision-making-in-the-surgical-management-of-invasive-breast-cancer-part-1-lumpectomy-mastectomy-and-contralateral-prophylactic-mastectomy
#12
REVIEW
Lisa A Newman
Several prospective randomized clinical trials conducted internationally have proven the safety and survival equivalence of breast-conserving surgery compared with mastectomy. Adjuvant radiation is routinely recommended following lumpectomy surgery to minimize the risk of local recurrence. Comprehensive breast imaging (including bilateral mammography with diagnostic views and ultrasound evaluation), in addition to clinical examination, is essential to rule out potential contralateral pathology and to optimally characterize the extent of disease...
May 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28508724/the-impact-of-simulated-motion-blur-on-lesion-detection-performance-in-full-field-digital-mammography
#13
Ahmed K Abdullah, John D Thompson, Claire E Mercer, Rob Aspin, Judith Kelly, Peter Hogg
OBJECTIVE: Motion blur is a known phenomenon in full-field digital mammography, but the impact on lesion detection is unknown. This is the first study to investigate detection performance with varying magnitudes of simulated motion blur. METHOD: Seven observers (15±5 years' reporting experience) evaluated 248 cases (62 containing malignant masses, 62 containing malignant microcalcifications and 124 normal cases) for three conditions: no blurring (0 mm) and two magnitudes of simulated blurring (0...
May 16, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28491319/macroscopic-lymphovascular-invasion-visualized-on-mammogram-and-magnetic-resonance-imaging-initially-misidentified-as-ductal-carcinoma-in-situ-but-properly-diagnosed-by-immunohistochemistry
#14
Linda M Sanders, Michael Dardik, Lopa Modi, Alison Esteva Sanders, Sarah S Schaefer, Anya Litvak
OBJECTIVES: Lymphovascular invasion (LVI) is a pathologic, microscopic finding associated with invasive cancer, and is a poor prognostic indicator, but has no reported imaging findings. This report presents the first documented case of LVI with seen by imaging. Linear branching microcalcifications were identified on mammography and clumped enhancement was noted on MRI, both imaging findings that are highly predictive of ductal carcinoma in situ (DCIS). METHODS: Ultrasound guided core biopsy of the dominant mass was performed, confirming invasive ductal malignancy...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/28490180/-category-4a-microcalcifications-how-should-this-subcategory-be-applied-to-microcalcifications-seen-on-mammography
#15
Jihee Kim, Eun-Kyung Kim, Min Jung Kim, Hee Jung Moon, Jung Hyun Yoon
Background The BI-RADS provides descriptors for microcalcifications based on morphology and distribution. However, the descriptor for category 4A microcalcifications is not specified in the 5th BI-RADS nor in the prior editions. Purpose To investigate how the category 4A assessment is applied to suspicious microcalcifications, and the appropriate descriptors for category 4A assessment for microcalcifications seen on mammography. Material and Methods From June 2008 to November 2011, 296 women with 305 suspicious microcalcifications that were assessed as BI-RADS category 4A, who underwent imaging-guided biopsy or surgery, were included...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28483014/value-of-contrast-enhanced-ultrasound-and-conventional-ultrasound-in-the-diagnosis-of-papillary-thyroid-carcinoma-with-cervical-lymph-node-metastases
#16
Yan Zhang, Yukun Luo, Mingbo Zhang, Ming Yang, Ying Zhang, Junlai Li, Jie Tang
Objective To compare the ultrasound features of papillary thyroid carcinoma with or without cervical lymph node metastasis (LNM). Methods Patients suspected of thyroid cancer underwent the conventional ultrasound and contrast-enhanced ultrasound (CEUS) examinations. Patients' age,sex,and ultrasound characteristics of lesions were recorded. With the surgical pathology as the golden standard,the ultrasound features were compared between the cervical LNM group and non-LNM group. Results Of 144 patients,51 had cervical LNM and 93 did not...
April 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28477395/quantitative-comparison-of-clustered-microcalcifications-in-for-presentation-and-for-processing-mammograms-in-full-field-digital-mammography
#17
Juan Wang, Robert M Nishikawa, Yongyi Yang
PURPOSE: Mammograms acquired with full-field digital mammography (FFDM) systems are provided in both "for-processing" and "for-presentation" image formats. For-presentation images are traditionally intended for visual assessment by the radiologists. In this study, we investigate the feasibility of using for-presentation images in computerized analysis and diagnosis of microcalcification (MC) lesions. METHODS: We make use of a set of 188 matched mammogram image pairs of MC lesions from 95 cases (biopsy proven), in which both for-presentation and for-processing images are provided for each lesion...
May 6, 2017: Medical Physics
https://www.readbyqxmd.com/read/28473100/coronary-artery-calcification-from-mechanism-to-molecular-imaging
#18
REVIEW
Takehiro Nakahara, Marc R Dweck, Navneet Narula, David Pisapia, Jagat Narula, H William Strauss
Vascular calcification is a hallmark of atherosclerosis. The location, density, and confluence of calcification may change portions of the arterial conduit to a noncompliant structure. Calcifications may also seed the cap of a thin cap fibroatheroma, altering tensile forces on the cap and rendering the lesion prone to rupture. Many local and systemic factors participate in this process, including hyperlipidemia, ongoing inflammation, large necrotic cores, and diabetes. Vascular cells can undergo chondrogenic or osteogenic differentiation, causing mineralization of membranous bone and formation of endochondral bone...
May 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28469438/visualization-of-breast-microcalcifications-on-digital-breast-tomosynthesis-and-2-dimensional-digital-mammography-using-specimens
#19
Jieun Byun, Jee Eun Lee, Eun Suk Cha, Jin Chung, Jeoung Hyun Kim
PURPOSE: The purpose of this study is to compare the visibility of microcalcifications of digital breast tomosynthesis (DBT) and full-field digital mammography (FFDM) using breast specimens. MATERIALS AND METHODS: Thirty-one specimens' DBT and FFDM were retrospectively reviewed by four readers. RESULTS: The image quality of microcalcifications of DBT was rated as superior or equivalent in 71.0% by reader 1, 67.8% by reader 2, 64.5% by reader 3, and 80...
2017: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/28468574/diagnostic-value-of-acoustic-radiation-force-impulse-quantification-in-the-differentiation-of-benign-and-malignant-thyroid-nodules
#20
Niraj Nirmal Pandey, Gaurav Shanker Pradhan, Alpana Manchanda, Anju Garg
The objective of this study was to evaluate the role of ultrasound elastography using acoustic radiation force impulse (ARFI) quantification in characterizing and differentiating malignant versus benign thyroid nodules. A total of 40 thyroid nodules were evaluated with conventional sonography and ultrasound elastography using ARFI quantification. The final diagnosis was obtained from histologic findings. A total of 14 malignant and 26 benign nodules were diagnosed on the basis of histologic examination. Majority of the malignant thyroid nodules demonstrated presence of intranodular vascular flow, hypoechoic echotexture, absent halo, irregular margins and microcalcifications...
May 1, 2017: Ultrasonic Imaging
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