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Microcalcifications

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https://www.readbyqxmd.com/read/29786482/human-epidermal-growth-factor-2-positive-breast-cancer-with-mammographic-microcalcification-relationship-to-pathologic-complete-response-after-neoadjuvant-chemotherapy
#1
Fayyaz A K Mazari, Nisha Sharma, David Dodwell, Kieran Horgan
Purpose To determine the relationship between the presence or absence of mammographic calcifications in human epidermal growth factor receptor 2 (HER2)-positive breast cancers and pathologic complete response (pCR) to neoadjuvant chemotherapy and to determine other tumor and clinical characteristics that may be predictive of such a response. Materials and Methods A database of all patients with HER2-positive breast cancer who underwent neoadjuvant chemotherapy between 2007 and 2015 was retrospectively reviewed...
May 16, 2018: Radiology
https://www.readbyqxmd.com/read/29781213/thyroid-microcalcifications-in-the-absence-of-identifiable-nodules-and-their-association-with-thyroid-cancer
#2
Carolina Whittle, Marisol García, Eleonora Horvath, Jeannie Slater, Carmen Carrasco
OBJECTIVES: To determine ultrasound (US) and clinical findings of thyroid microcalcifications in the absence of a nodule and their association with the risk of malignancy. METHODS: The Institutional Review Board approved a 5-year retrospective study. Twenty-one patients with clustered or scattered thyroid microcalcifications in the absence of nodules on US images who underwent fine-needle aspiration biopsies (FNABs) were included. Demographic and clinical data, US findings, and pathologic results were registered...
May 21, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29774361/diagnostic-performance-of-ata-bta-and-tirads-sonographic-patterns-in-the-predication-of-malignancy-in-histologically-proven-thyroid-nodules
#3
Chiaw Ling Chng, Hong Chang Tan, Chow Wei Too, Wei Ying Lim, Priscilla Pei Sze Chiam, Ling Zhu, Nivedita Vikas Nadkarni, Adoree Yi Ying Lim
INTRODUCTION: We aimed to compare the malignancy risk stratification of histologically proven thyroid nodules using the 2015 American Thyroid Association (ATA) Management Guidelines, 2014 British Thyroid Association (BTA) Guidelines for the Management of Thyroid Cancer and Thyroid Imaging Reporting and Data System (TIRADS). METHODS: Thyroid nodules measuring > 1 cm resected over 5.5 years were retrospectively studied. Information like gender and age, and cytology and histopathology results were collected...
May 18, 2018: Singapore Medical Journal
https://www.readbyqxmd.com/read/29772934/image-guided-vacuum-assisted-breast-biopsy-in-the-diagnosis-of-breast-microcalcifications
#4
Jun Liu, Linping Huang
Objective The present study was performed to assess the accuracy and clinical value of image-guided vacuum-assisted breast biopsy in the diagnosis of mammography-detected breast microcalcifications. Methods This prospective study involved 100 patients with suspicious mammography-detected microcalcifications who underwent image-guided vacuum-assisted breast biopsies from January 2013 to October 2016. Stereotactic vacuum-assisted breast biopsy (SVAB) was performed in 64 patients, and ultrasound (US)-guided vacuum-assisted breast biopsy (US-VAB) was performed in 36 patients in whom application of SVAB was difficult...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29768928/automated-daily-quality-control-analysis-for-mammography-in-a-multi-unit-imaging-center
#5
Veli-Matti Sundell, Teemu Mäkelä, Alexander Meaney, Touko Kaasalainen, Sauli Savolainen
Background The high requirements for mammography image quality necessitate a systematic quality assurance process. Digital imaging allows automation of the image quality analysis, which can potentially improve repeatability and objectivity compared to a visual evaluation made by the users. Purpose To develop an automatic image quality analysis software for daily mammography quality control in a multi-unit imaging center. Material and Methods An automated image quality analysis software using the discrete wavelet transform and multiresolution analysis was developed for the American College of Radiology accreditation phantom...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29764199/change-in-microcalcifications-on-mammography-after-neoadjuvant-chemotherapy-in-breast-cancer-patients-correlation-with-tumor-response-grade-and-comparison-with-lesion-extent
#6
Hyunee Yim, Taeyang Ha, Doo Kyoung Kang, Seong Young Park, Yongsik Jung, Tae Hee Kim
Background After neoadjuvant chemotherapy (NAC), persistent microcalcifications are often observed in spite of a decrease in the primary tumor size. Purpose To analyze the changes in microcalcifications after NAC and to evaluate the accuracy of residual microcalcifications in predicting the extent of residual cancer. Material and Methods Eighty patients who received NAC and underwent both mammography and magnetic resonance imaging (MRI) before and after the completion of NAC were included. The location of microcalcifications was classified into two types: inside the mass and outside the mass...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29761698/assessment-of-compressive-raman-versus-hyperspectral-raman-for-microcalcification-chemical-imaging
#7
Camille Scotté, Hilton B de Aguiar, Didier Marguet, Ellen Marie Green, Pascaline Bouzy, Sébastien Vergnole, Charles Peter Winlove, Nicholas Stone, Herve Rigneault
We experimentally implement a compressive Raman technology (CRT) that incorporates chemometric analysis directly into the spectrometer hardware by means of a digital micromirror device (DMD). The DMD is a programmable optical filter on which optimized binary filters are displayed. The latter are generated with an algorithm based on the Cramer-Rao lower bound. We com-pared the developed CRT microspectrometer with two conventional state-of-the-art Raman hyperspectral imaging systems on samples mimicking microcalcifications relevant for breast cancer diagnosis...
May 15, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29760786/ultrasound-criteria-for-risk-stratification-of-thyroid-nodules-in-the-previously-iodine-deficient-area-of-austria-a-single-centre-retrospective-analysis
#8
Christina Tugendsam, Veronika Petz, Wolfgang Buchinger, Brigitta Schmoll-Hauer, Iris Pia Schenk, Karin Rudolph, Michael Krebs, Georg Zettinig
Background: We aimed to study the validity of six published ultrasound criteria for risk stratification of thyroid nodules in the former severely iodine deficient population of Austria. Methods: Retrospective, single centre, observer blinded study design. All patients with a history of thyroidectomy due to nodules seen in the centre between 2004 and 2014 with preoperative in-house sonography and documented postoperative histology were analyzed ( n  = 195). A board of five experienced thyroidologists evaluated the images of 45 papillary carcinomas, 8 follicular carcinomas, and 142 benign nodules regarding the following criteria: mild hypoechogenicity, marked hypoechogenicity, microlobulated or irregular margins, microcalcifications, taller than wide shape, missing thin halo...
2018: Thyroid Research
https://www.readbyqxmd.com/read/29760433/diagnostic-value-of-ultrasound-features-and-sex-of-fetuses-in-female-patients-with-papillary-thyroid-microcarcinoma
#9
Chun-Jie Hou, Ran Wei, Jing-Lan Tang, Qiao-Hong Hu, Hong-Feng He, Xiao-Ming Fan
Little work has been done on the prediction of papillary thyroid microcarcinoma in female patients who have given birth to children, which may be different from other people. We performed a retrospective review of female patients who underwent thyroidectomy, aiming at identifying special predictors of papillary thyroid microcarcinoma in female patients who have given birth to children. Univariate analysis was used to identify potential covariates for the prediction of papillary thyroid microcarcinoma. Multivariable logistic regression analysis was used to identify independent predictors and construct a regression model based on a training cohort (246 patients) and then the regression model was validated using an independent cohort (80 patients)...
May 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29753636/coronary-arterial-calcification-a-review-of-mechanisms-promoters-and-imaging
#10
REVIEW
Jordan Andrews, Peter J Psaltis, Belinda A Di Bartolo, Stephen J Nicholls, Rishi Puri
Coronary artery calcification (CAC) was once thought to be a passive, degenerative, and quiescent development of disease. However, it has now been shown to be an active process associated with atherosclerosis that is stimulated by inflammatory pathways. Calcification forms within the intimal and medial layers of the vessel wall by way of mechanisms similar to bone development. A variety of imaging modalities have been used to identify and characterize CAC, from early microcalcifications to well-developed fibroatheromas that have calcified...
May 2, 2018: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29751516/engineering-a-3d-bioprinted-model-of-human-heart-valve-disease-using-nanoindentation-based-biomechanics
#11
Dewy C van der Valk, Casper F T van der Ven, Mark C Blaser, Joshua M Grolman, Pin-Jou Wu, Owen S Fenton, Lang H Lee, Mark W Tibbitt, Jason L Andresen, Jennifer R Wen, Anna H Ha, Fabrizio Buffolo, Alain van Mil, Carlijn V C Bouten, Simon C Body, David J Mooney, Joost P G Sluijter, Masanori Aikawa, Jesper Hjortnaes, Robert Langer, Elena Aikawa
In calcific aortic valve disease (CAVD), microcalcifications originating from nanoscale calcifying vesicles disrupt the aortic valve (AV) leaflets, which consist of three (biomechanically) distinct layers: the fibrosa, spongiosa, and ventricularis. CAVD has no pharmacotherapy and lacks in vitro models as a result of complex valvular biomechanical features surrounding resident mechanosensitive valvular interstitial cells (VICs). We measured layer-specific mechanical properties of the human AV and engineered a three-dimensional (3D)-bioprinted CAVD model that recapitulates leaflet layer biomechanics for the first time...
May 3, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29744755/radiological-histological-and-chemical-analysis-of-breast-microcalcifications-diagnostic-value-and-biological-significance
#12
Rita Bonfiglio, Manuel Scimeca, Nicola Toschi, Chiara Adriana Pistolese, Elena Giannini, Chiara Antonacci, Sara Ciuffa, Virginia Tancredi, Umberto Tarantino, Loredana Albonici, Elena Bonanno
Classification of mammary microcalcifications is based on radiological and histological characteristics that are routinely evaluated during the diagnostic path for the identification of breast cancer, or in patients at risk of developing breast cancer. The main aim of this study was to explore the relationship between the imaging parameters most commonly used for the study of mammary microcalcifications and the corresponding histological and chemical properties. To this end, we matched the radiographic characteristics of microcalcifications to breast lesion type, histology of microcalcifications and elemental composition of microcalcifications as obtained by energy dispersive x ray (EDX)-microanalysis...
May 9, 2018: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/29743738/ultrasound-guided-biopsy-of-breast-calcifications-using-a-new-image-processing-technique-initial-experience
#13
Almir Galvão Vieira Bitencourt, Luciana Graziano, Camila Souza Guatelli, Maria Luiza Lima Albuquerque, Elvira Ferreira Marques
The aim of this paper is to describe the use of a new ultrasound imaging processing technique to guide biopsies of suspicious breast calcifications. We used this technique in 13 patients with suspicious breast calcifications that could not be submitted to stereotactic biopsy. Suspicious calcifications were identified by ultrasound, and the biopsy was successfully performed in all cases. Although mammography continues to be the method of choice for the detection and characterization of microcalcifications, this new technique can be an alternative means of guiding biopsy procedures in selected patients who are not candidates for stereotactic biopsy...
March 2018: Radiologia Brasileira
https://www.readbyqxmd.com/read/29743735/suspicious-amorphous-microcalcifications-detected-on-full-field-digital-mammography-correlation-with-histopathology
#14
Vera Christina Camargo de Siqueira Ferreira, Elba Cristina Sá de Camargo Etchebehere, José Luiz Barbosa Bevilacqua, Nestor de Barros
Objective: To evaluate suspicious amorphous calcifications diagnosed on full-field digital mammography (FFDM) and establish correlations with histopathology findings. Materials and Methods: This was a retrospective study of 78 suspicious amorphous calcifications (all classified as BI-RADS® 4) detected on FFDM. Vacuum-assisted breast biopsy (VABB) was performed. The histopathological classification of VABB core samples was as follows: pB2 (benign); pB3 (uncertain malignant potential); pB4 (suspicion of malignancy); and pB5 (malignant)...
March 2018: Radiologia Brasileira
https://www.readbyqxmd.com/read/29742599/the-detection-of-uterine-leiomyoma-fibroid-calcifications-on-18f-naf-pet-ct
#15
Abdullah Al-Zaghal, Thomas J Werner, Poul F Høilund-Carlsen, Abass Alavi
Uterine leiomyomas (fibroids) are the most common type of uterine neoplasms in premenopausal women. Leiomyomas are estrogen dependent and tend to atrophy and shrink in size after menopause. Dystrophic calcification, cystic changes, and necrosis are among the changes that indicate uterine fibroid involution. We are presenting a calcified uterine leiomyoma in a 61-year-old woman as incidentally detected on F-NaF PET/CT scanning. Many previous publications have reported the accumulation of F-NaF in soft tissue calcifications; these findings further set new directions in the evaluation of the metabolic activity of macrocalcification and microcalcification using molecular imaging probes...
May 7, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29733273/compressibility-and-density-weighting-for-ultrasound-scattering-tomography
#16
Quinn Barber, Roger J Zemp
A novel reconstruction technique based on delay-and-sum ultrasound tomography algorithms is introduced. This reconstruction technique enables ultrasound tomographic systems to produce compressibility- and density-weighted images (D-WI) for spherically symmetric ultrasound scatterers. The efficacy of this reconstruction technique was demonstrated with simulation and phantom experiments. Separation between a dense wire target and a compressible thread target within a phantom was quantified, showing an increased signal of the wire target for D-WIs...
May 2018: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/29730729/incorporation-of-the-technologist-s-opinion-for-arbitration-of-discrepant-assessments-among-radiologists-at-screening-mammography
#17
Angela M P Coolen, Joost R C Lameijer, Adri C Voogd, Luc J Strobbe, Marieke W J Louwman, Vivianne C G Tjan-Heijnen, Lucien E M Duijm
PURPOSE: We determined whether the addition of the technologist's opinion may be helpful in deciding if discordant readings at blinded double reading should be recalled. METHODS: A consecutive series of 99,013 digital screening mammograms, obtained between July 2013 and January 2015, were included. All mammograms were first interpreted by a technologist and then double read in a blinded fashion by a team of 13 screening radiologists. All concordant and discordant positive readings among radiologists were recalled...
May 5, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29730514/breastfeeding-difficulty-after-polyacrylamide-hydrogel-paag-mediated-breast-augmentation
#18
Rami Mossad Ibrahim, Elisabeth Lauritzen, Caspar Weel Krammer
INTRODUCTION: Breast augmentation using polyacrylamide hydrogel (PAAG) has been routinely used in the past as a minimal invasive procedure. However, several patients undergoing this procedure have started to report complications. We report a case of breast augmentation using PAAG leading to a delayed infection and breastfeeding complication. CLINICAL CASE: A 36-year-old Danish female who was treated with PAAG fifteen years earlier, presented with difficulty in breastfeeding and fistulation...
April 30, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29725017/establishment-and-validation-of-the-scoring-system-for-preoperative-prediction-of-central-lymph-node-metastasis-in-papillary-thyroid-carcinoma
#19
Wen Liu, Ruochuan Cheng, Yunhai Ma, Dan Wang, Yanjun Su, Chang Diao, Jianming Zhang, Jun Qian, Jin Liu
Early preoperative diagnosis of central lymph node metastasis (CNM) is crucial to improve survival rates among patients with papillary thyroid carcinoma (PTC). Here, we analyzed clinical data from 2862 PTC patients and developed a scoring system using multivariable logistic regression and testified by the validation group. The predictive diagnostic effectiveness of the scoring system was evaluated based on consistency, discrimination ability, and accuracy. The scoring system considered seven variables: gender, age, tumor size, microcalcification, resistance index >0...
May 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29721016/the-association-of-thyroid-nodules-with-metabolic-status-a-cross-sectional-spect-china-study
#20
Yi Chen, Chunfang Zhu, Yingchao Chen, Ningjian Wang, Qin Li, Bing Han, Li Zhao, Chi Chen, Hualing Zhai, Yingli Lu
Purpose: The aim of this study was to investigate the association of thyroid nodules (TNs) and their ultrasound (US) characteristics related to malignancy with metabolic status. Methods: The data were obtained from a cross-sectional study (SPECT-China, 2014-2015). The study included 9898 participants older than 18 years. Participants underwent several checkups, which included the measurement of anthropometric parameters, blood pressure, TSH levels, glucose, and lipid profiles...
2018: International Journal of Endocrinology
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