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Microcalcifications

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https://www.readbyqxmd.com/read/28534354/the-value-of-stereotactic-vacuum-assisted-breast-biopsy-in-the-investigation-of-microcalcifications-a-six-year-experience-with-853-patients
#1
Panagiotis M Safioleas, Dimitra Koulocheri, Nikolaos Michalopoulos, Paraskevi Liacou, Ioannis Flessas, Afroditi Nonni, Konstantinos Kontzoglou, George C Zografos
PURPOSE: Vacuum Assisted Breast Biopsy (VABB) is a minimal invasive technique, in the diagnostic approach for non palpable lesions. The aim of this study was to evaluate the efficacy and accuracy of VABB in the investigation of breast microcalcifications, a significant mammographic sign of early breast cancer. The rate of histological underestimation and the false negative rate were assessed based on the follow up data and the histological examination of the surgical specimens. METHODS: From January 2005 to November 2011, 853 women with mammographically detected microcalcifications, classified as BI-RADS 3-5, were referred to our Breast Unit for evaluation...
March 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28526187/chemotherapy-may-eradicate-ductal-carcinoma-in-situ-dcis-but-not-the-associated-microcalcifications
#2
H Goldberg, J Zandbank, V Kent, M Leonov-Polak, A Livoff, A Chernihovsky, M Guindy, E Evron
INTRODUCTION: We studied the effect of neoadjuvant chemotherapy (NAC) ± trastuzumab on the ductal carcinoma in situ (DCIS) component in patients with locally advanced breast cancer who achieved pathological complete response (pCR). METHODS: The diagnostic biopsies of 92 consecutive breast cancer patients that were treated with neoadjuvant chemotherapy (NAC) ± trastuzumab were evaluated for the presence of DCIS. Upon completion of NAC, the surgical specimens were evaluated for complete eradication of both the invasive and non-invasive cancer in the breast...
May 4, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28523326/hashimoto-s-thyroiditis-associated-with-thyroid-adenoma-with-h%C3%A3-rthle-cells-case-report
#3
Mihaela Stanciu, Liana Gabriela Bera, Mihaela Popescu, Florin Grosu, Florina Ligia Popa
Chronic thyroiditis may present a focal lesion, often-palpable abnormality, simulating nodular disease. The number and morphology of the Hürthle cells (HC) vary in the thyroid aspirate. Distinguishing between neoplastic and non-neoplastic HC lesions is difficult when using the fine-needle aspiration cytology (FNAC). We present the case of a 46-year-old female with a large right nodular goiter and hypothyroidism and high titer of anti-thyroid peroxidase antibody (TPO). The thyroid ultrasound showed a large well-defined nodule (more than 6...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28512732/decision-making-in-the-surgical-management-of-invasive-breast-cancer-part-1-lumpectomy-mastectomy-and-contralateral-prophylactic-mastectomy
#4
REVIEW
Lisa A Newman
Several prospective randomized clinical trials conducted internationally have proven the safety and survival equivalence of breast-conserving surgery compared with mastectomy. Adjuvant radiation is routinely recommended following lumpectomy surgery to minimize the risk of local recurrence. Comprehensive breast imaging (including bilateral mammography with diagnostic views and ultrasound evaluation), in addition to clinical examination, is essential to rule out potential contralateral pathology and to optimally characterize the extent of disease...
May 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28508724/the-impact-of-simulated-motion-blur-on-lesion-detection-performance-in-full-field-digital-mammography
#5
Ahmed K Abdullah, John D Thompson, Claire E Mercer, Rob Aspin, Judith Kelly, Peter Hogg
OBJECTIVE: Motion blur is a known phenomenon in full-field digital mammography, but the impact on lesion detection is unknown. This is the first study to investigate detection performance with varying magnitudes of simulated motion blur. METHOD: Seven observers (15±5 years' reporting experience) evaluated 248 cases (62 containing malignant masses, 62 containing malignant microcalcifications and 124 normal cases) for three conditions: no blurring (0 mm) and two magnitudes of simulated blurring (0...
May 16, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28491319/macroscopic-lymphovascular-invasion-visualized-on-mammogram-and-magnetic-resonance-imaging-initially-misidentified-as-ductal-carcinoma-in-situ-but-properly-diagnosed-by-immunohistochemistry
#6
Linda M Sanders, Michael Dardik, Lopa Modi, Alison Esteva Sanders, Sarah S Schaefer, Anya Litvak
OBJECTIVES: Lymphovascular invasion (LVI) is a pathologic, microscopic finding associated with invasive cancer, and is a poor prognostic indicator, but has no reported imaging findings. This report presents the first documented case of LVI with seen by imaging. Linear branching microcalcifications were identified on mammography and clumped enhancement was noted on MRI, both imaging findings that are highly predictive of ductal carcinoma in situ (DCIS). METHODS: Ultrasound guided core biopsy of the dominant mass was performed, confirming invasive ductal malignancy...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/28490180/-category-4a-microcalcifications-how-should-this-subcategory-be-applied-to-microcalcifications-seen-on-mammography
#7
Jihee Kim, Eun-Kyung Kim, Min Jung Kim, Hee Jung Moon, Jung Hyun Yoon
Background The BI-RADS provides descriptors for microcalcifications based on morphology and distribution. However, the descriptor for category 4A microcalcifications is not specified in the 5th BI-RADS nor in the prior editions. Purpose To investigate how the category 4A assessment is applied to suspicious microcalcifications, and the appropriate descriptors for category 4A assessment for microcalcifications seen on mammography. Material and Methods From June 2008 to November 2011, 296 women with 305 suspicious microcalcifications that were assessed as BI-RADS category 4A, who underwent imaging-guided biopsy or surgery, were included...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28483014/value-of-contrast-enhanced-ultrasound-and-conventional-ultrasound-in-the-diagnosis-of-papillary-thyroid-carcinoma-with-cervical-lymph-node-metastases
#8
Yan Zhang, Yukun Luo, Mingbo Zhang, Ming Yang, Ying Zhang, Junlai Li, Jie Tang
Objective To compare the ultrasound features of papillary thyroid carcinoma with or without cervical lymph node metastasis (LNM). Methods Patients suspected of thyroid cancer underwent the conventional ultrasound and contrast-enhanced ultrasound (CEUS) examinations. Patients' age,sex,and ultrasound characteristics of lesions were recorded. With the surgical pathology as the golden standard,the ultrasound features were compared between the cervical LNM group and non-LNM group. Results Of 144 patients,51 had cervical LNM and 93 did not...
April 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28477395/quantitative-comparison-of-clustered-microcalcifications-in-for-presentation-and-for-processing-mammograms-in-full-field-digital-mammography
#9
Juan Wang, Robert M Nishikawa, Yongyi Yang
PURPOSE: Mammograms acquired with full-field digital mammography (FFDM) systems are provided in both "for-processing" and "for-presentation" image formats. For-presentation images are traditionally intended for visual assessment by the radiologists. In this study, we investigate the feasibility of using for-presentation images in computerized analysis and diagnosis of microcalcification (MC) lesions. METHODS: We make use of a set of 188 matched mammogram image pairs of MC lesions from 95 cases (biopsy proven), in which both for-presentation and for-processing images are provided for each lesion...
May 6, 2017: Medical Physics
https://www.readbyqxmd.com/read/28473100/coronary-artery-calcification-from-mechanism-to-molecular-imaging
#10
REVIEW
Takehiro Nakahara, Marc R Dweck, Navneet Narula, David Pisapia, Jagat Narula, H William Strauss
Vascular calcification is a hallmark of atherosclerosis. The location, density, and confluence of calcification may change portions of the arterial conduit to a noncompliant structure. Calcifications may also seed the cap of a thin cap fibroatheroma, altering tensile forces on the cap and rendering the lesion prone to rupture. Many local and systemic factors participate in this process, including hyperlipidemia, ongoing inflammation, large necrotic cores, and diabetes. Vascular cells can undergo chondrogenic or osteogenic differentiation, causing mineralization of membranous bone and formation of endochondral bone...
May 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28469438/visualization-of-breast-microcalcifications-on-digital-breast-tomosynthesis-and-2-dimensional-digital-mammography-using-specimens
#11
Jieun Byun, Jee Eun Lee, Eun Suk Cha, Jin Chung, Jeoung Hyun Kim
PURPOSE: The purpose of this study is to compare the visibility of microcalcifications of digital breast tomosynthesis (DBT) and full-field digital mammography (FFDM) using breast specimens. MATERIALS AND METHODS: Thirty-one specimens' DBT and FFDM were retrospectively reviewed by four readers. RESULTS: The image quality of microcalcifications of DBT was rated as superior or equivalent in 71.0% by reader 1, 67.8% by reader 2, 64.5% by reader 3, and 80...
2017: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/28468574/diagnostic-value-of-acoustic-radiation-force-impulse-quantification-in-the-differentiation-of-benign-and-malignant-thyroid-nodules
#12
Niraj Nirmal Pandey, Gaurav Shanker Pradhan, Alpana Manchanda, Anju Garg
The objective of this study was to evaluate the role of ultrasound elastography using acoustic radiation force impulse (ARFI) quantification in characterizing and differentiating malignant versus benign thyroid nodules. A total of 40 thyroid nodules were evaluated with conventional sonography and ultrasound elastography using ARFI quantification. The final diagnosis was obtained from histologic findings. A total of 14 malignant and 26 benign nodules were diagnosed on the basis of histologic examination. Majority of the malignant thyroid nodules demonstrated presence of intranodular vascular flow, hypoechoic echotexture, absent halo, irregular margins and microcalcifications...
May 1, 2017: Ultrasonic Imaging
https://www.readbyqxmd.com/read/28467655/microcalcification-of-lumbar-spine-intervertebral-discs-and-facet-joints-is-associated-with-cartilage-degeneration-but-differs-in-prevalence-and-its-relation-to-age
#13
Thelonius Hawellek, Jan Hubert, Sandra Hischke, Tim Rolvien, Matthias Krause, Klaus Püschel, Wolfgang Rüther, Andreas Niemeier
Cartilage calcification (CC) is associated with degeneration in non-vertebral joints, but little is known about CC and lumbar vertebral joints. The goal of this study was to analyze the prevalence of CC in lumbar facet joints (FJ) and intervertebral discs (IVD) and its relation to cartilage degeneration and age in a non-selected cohort of the general population. The segment L4/5 of 85 consecutive donors (mean age 61.9 years) was analyzed by high-resolution imaging digital-contact radiography (DCR). Quantification was achieved by measuring CC in % of total cartilage area...
May 3, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28466029/global-detection-approach-for-clustered-microcalcifications-in-mammograms-using-a-deep-learning-network
#14
Juan Wang, Robert M Nishikawa, Yongyi Yang
In computerized detection of clustered microcalcifications (MCs) from mammograms, the traditional approach is to apply a pattern detector to locate the presence of individual MCs, which are subsequently grouped into clusters. Such an approach is often susceptible to the occurrence of false positives (FPs) caused by local image patterns that resemble MCs. We investigate the feasibility of a direct detection approach to determining whether an image region contains clustered MCs or not. Toward this goal, we develop a deep convolutional neural network (CNN) as the classifier model to which the input consists of a large image window ([Formula: see text] in size)...
April 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28465260/is-ultrasonographically-detected-nodule-diameter-concordant-with-pathological-tumor-size
#15
Muhammet Cuneyt Bilginer, Didem Ozdemir, Husniye Baser, Hayriye Tatli Dogan, Abdussamed Yalcin, Reyhan Ersoy, Bekir Cakir
INTRODUCTION: We aimed to compare preoperative ultrasonographical and postoperative histopathological diameters of differentiated thyroid cancer (DTC) lesions and investigate possible factors that can predict the discordance between two measurements. METHODS: Data of patients with histopathologically confirmed DTC were reviewed retrospectively. Nodules evaluated by preoperative US were matched with histopathologically examined nodules. Incidental tumors and nodules that can not be matched in US and histopathology reports were excluded...
April 29, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28463412/role-of-superb-micro-vascular-imaging-in-the-preoperative-evaluation-of-thyroid-nodules-comparison-with-power-doppler-flow-imaging
#16
Jing Kong, Jian-Chu Li, Hong-Yan Wang, Ya-Hong Wang, Rui-Na Zhao, Ying Zhang, Jin Jin
OBJECTIVES: To evaluate whether Superb Micro-Vascular Imaging (SMI; Toshiba Medical Systems Corporation, Tochigi, Japan) is superior to power Doppler flow imaging (PDFI) in depicting thyroid nodular vascularity and to primarily explore the diagnostic performance of vascularity on SMI integrated with grayscale sonographic features for diagnosis of malignant thyroid nodules. METHODS: Ninety-two resident patients with 113 nodules for surgery were included in the study...
April 30, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28450564/diagnostic-pet-imaging-of-mammary-microcalcifications-using-64-cu-dota-alendronate-in-a-rat-model-of-breast-cancer
#17
Bradley J Ahrens, Lin Li, Alexandra K Ciminera, Junie Chea, Erasmus Poku, James R Bading, Michael R Weist, Marcia M Miller, David M Colcher, John E Shively
The development of improved breast cancer screening methods is hindered by a lack of cancer specific imaging agents and effective small animal models to test them. The purpose of this study was to evaluate (64)Cu-DOTA-alendronate as a mammary microcalcification targeting PET imaging agent, using an ideal rat model. Our long-term goal is to develop (64)Cu-DOTA-alendronate for the detection and non-invasive differentiation of malignant versus benign breast tumors with PET. Methods: DOTA-alendronate was synthesized, radiolabeled with (64)Cu and administered to normal or tumor-bearing aged, female, retired breeder, Sprague Dawley rats for PET imaging...
April 27, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28444144/congenital-zika-virus-infection-induces-severe-spinal-cord-injury
#18
Fernando S Ramalho, Aparecida Y Yamamoto, Luis L da Silva, Luiz Tm Figueiredo, Lenaldo B Rocha, Luciano Neder, Sara R Teixeira, Letícia A Apolinário, Leandra Nz Ramalho, Deisy M Silva, Conrado M Coutinho, Patrícia P Melli, Marlei J Augusto, Ligia B Santoro, Geraldo Duarte, Marisa M Mussi-Pinhata
We reported two fatal cases of congenital Zika virus (ZIKV) infection. Brain anomalies including atrophy of the cerebral cortex and brainstem, and cerebellar aplasia were observed. The spinal cord showed architectural distortion, severe neuronal loss and microcalcifications. The ZIKV proteins and flavivirus-like particles were detected in cytoplasm of spinal neurons, and spinal cord samples were positive for the ZIKV RNA.
April 21, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28436856/task-based-modeling-of-an-5k-ultra-high-resolution-medical-imaging-system-for-digital-breast-tomosynthesis
#19
Chumin Zhao, Jerzy Kanicki
High-resolution, low noise x-ray detectors based on CMOS active pixel sensor (APS) technology have demonstrated superior imaging performance for digital breast tomosynthesis (DBT). This paper presents a task-based model for a high resolution medical imaging system to evaluate its ability to detect simulated microcalcifications and masses as lesions for breast cancer. Three-dimensional (3D) cascaded system analysis for a 50 μm pixel pitch CMOS APS x-ray detector was integrated with an object task function, a medical imaging display model, and the human eye contrast sensitivity function to calculate the detectability index and area under the ROC curve (AUC)...
April 19, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28420325/usefulness-of-grayscale-inverted-images-in-addition-to-standard-images-in-digital-mammography
#20
Ayşegül Altunkeser, M Kazım Körez
BACKGROUND: Mammography is essential for early diagnosis of breast cancer, which is the most common type of cancer in females that is associated with a high mortality rate. We investigated whether evaluation of the grayscale inverted images of mammograms would aid in increasing the diagnostic sensitivity of the mammographic imaging technique. METHODS: Our study included 636 mammograms of 159 women who had undergone digital mammography. Standard, grayscale inverted, and standard plus grayscale inverted images were sequentially examined three times, at 15-day intervals, for the presence or assessment of pathological changes in the skin, calcification, asymmetric density, mass lesions, structural distortions, and intramammary and axillary lymph nodes...
April 18, 2017: BMC Medical Imaging
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