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Microcalcifications

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https://www.readbyqxmd.com/read/29313119/distribution-patterns-of-microcalcifications-in-suspected-thyroid-carcinoma-a-classification-method-helpful-for-diagnosis
#1
Chun-Ping Ning, Qing-Lian Ji, Shi-Bao Fang, Hong-Qiao Wang, Yan-Mi Zhong, Hai-Tao Niu
PURPOSE: The aim of this study was to compare the distribution patterns of microcalcifications in thyroid cancers with benign cases. METHODS: In total, 358 patients having microcalcifications on ultrasonography were analysed. Microcalcifications were categorised according to the distribution patterns: (I) microcalcifications inside one (a) or more (b) suspected nodules, (II) microcalcifications not only inside but also surrounding a suspected single (a) or multiple (b) nodules, and (III) focal (a) or diffuse (b) microcalcifications in the absence of any suspected nodule...
January 8, 2018: European Radiology
https://www.readbyqxmd.com/read/29312581/ultrasound-and-clinicopathological-features-of-papillary-thyroid-carcinomas-with-braf-and-tert-promoter-mutations
#2
Soo Yeon Hahn, Tae Hyuk Kim, Chang Seok Ki, Sun Wook Kim, Soohyun Ahn, Jung Hee Shin, Jae Hoon Chung
This study is to investigate if any relationship exists between the telomerase reverse transcriptase (TERT) promoter or proto-oncogene BRAF mutation and ultrasound (US) and clinicopathological features of papillary thyroid carcinomas (PTCs). The study included 150 patients with surgically confirmed PTC from October 1994 to December 2004. According to the existence of TERT promoter or BRAF mutations, we categorized patients into three groups (no mutation, BRAF mutation alone, or TERT+BRAF mutations) and analyzed the relationships between TERT promoter or BRAF mutation and US and clinicopathological features...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29302784/initial-results-of-the-fusion-x-us-prototype-combining-3d-automated-breast-ultrasound-and-digital-breast-tomosynthesis
#3
Benedikt Schaefgen, Joerg Heil, Richard G Barr, Marcus Radicke, Aba Harcos, Christina Gomez, Anne Stieber, André Hennigs, Alexandra von Au, Julia Spratte, Geraldine Rauch, Joachim Rom, Florian Schütz, Christof Sohn, Michael Golatta
PURPOSE: To determine the feasibility of a prototype device combining 3D-automated breast ultrasound (ABVS) and digital breast tomosynthesis in a single device to detect and characterize breast lesions. METHODS: In this prospective feasibility study, the FUSION-X-US prototype was used to perform digital breast tomosynthesis and ABVS in 23 patients with an indication for tomosynthesis based on current guidelines after clinical examination and standard imaging. The ABVS and tomosynthesis images of the prototype were interpreted separately by two blinded experts...
January 4, 2018: European Radiology
https://www.readbyqxmd.com/read/29301708/coronary-artery-calcification-and%C3%A2-its%C3%A2-progression-what-does-it-really-mean
#4
REVIEW
Hiroyoshi Mori, Sho Torii, Matthew Kutyna, Atsushi Sakamoto, Aloke V Finn, Renu Virmani
Coronary artery calcification is concomitant with the development of advanced atherosclerosis. Coronary artery calcification pathologically begins as microcalcifications (0.5 to 15.0 μm) and grows into larger calcium fragments, which eventually result in sheet-like deposits (>3 mm). This evolution is observed to occur concurrently with the progression of plaque. These fragments and sheets of calcification can be easily identified by radiography as well as by computed tomography and intravascular imaging...
January 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29286207/microcalcifications-in-the-breast-secondary-to-augmentation-by-filler-injections
#5
Lance S Eberson, Kimberly A Fitzpatrick, Wendy S Mackerricher, Douglas R Bourgon, Marisa H Borders
No abstract text is available yet for this article.
December 29, 2017: Breast Journal
https://www.readbyqxmd.com/read/29274344/calcium-phosphate-particles-stimulate-interleukin-1%C3%AE-release-from-human-vascular-smooth-muscle-cells-a-role-for-spleen-tyrosine-kinase-and-exosome-release
#6
Yana Dautova, Alexander N Kapustin, Kevin Pappert, Matthias Epple, Hanneke Okkenhaug, Simon J Cook, Catherine M Shanahan, Martin D Bootman, Diane Proudfoot
AIMS: Calcium phosphate (CaP) particle deposits are found in several inflammatory diseases including atherosclerosis and osteoarthritis. CaP, and other forms of crystals and particles, can promote inflammasome formation in macrophages leading to caspase-1 activation and secretion of mature interleukin-1β (IL-1β). Given the close association of small CaP particles with vascular smooth muscle cells (VSMCs) in atherosclerotic fibrous caps, we aimed to determine if CaP particles affected pro-inflammatory signalling in human VSMCs...
December 20, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29247886/microcalcification-morphological-descriptors-and-parenchyma-fractal-dimension-hierarchically-interact-in-breast-cancer-a-diagnostic-perspective
#7
Garima Verma, Maria Laura Luciani, Alessandro Palombo, Linda Metaxa, Giovanna Panzironi, Federica Pediconi, Alessandro Giuliani, Mariano Bizzarri, Virginia Todde
INTRODUCTION: Herein, we propose a Systems Biology approach aimed at identifying quantitative morphological parameters useful in discriminating benign from malignant breast microcalcifications at digital mammography. MATERIALS AND METHODS: The study includes 31 patients in which microcalcifications had been detected during XR mammography and were further confirmed by stereotactic (XR-guided) biopsies. Patients were classified according to the BIRADS (Breast Imaging-Reporting and Data System), along with their parenchyma fractal dimension and biopsy size...
December 11, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29247582/american-thyroid-association-ultrasound-system-for-the-initial-assessment-of-thyroid-nodules-use-in-stratifying-the-risk-of-malignancy-of-indeterminate-lesions
#8
Pierpaolo Trimboli, Maurilio Deandrea, Alberto Mormile, Luca Ceriani, Francesca Garino, Paolo P Limone, Luca Giovanella
BACKGROUND: The ultrasound risk stratification system of the American Thyroid Association (ATA) is frequently adopted in clinical practice. Here, we evaluated its performance in a series of nodules with indeterminate fine-needle aspiration cytology (FNAC) report. METHODS: Indeterminate thyroid nodules diagnosed at 2 medical centers were retrospectively screened, ultrasound images were reevaluated, and lesions were classified according to the ATA. Single ultrasound parameters were also analyzed...
December 16, 2017: Head & Neck
https://www.readbyqxmd.com/read/29242735/microcalcified-hepatic-metastases-incidentally-detected-on-f-18-naf-pet-ct-in-a-patient-with-prostate-cancer
#9
Gul Ege Aktas, Ali Sarıkaya, Nuray Can, Selin Soyluoglu Demir
F-18 NaF PET/CT evaluation has gained importance in recent years. Achievements from F-18 NaF PET/CT are: higher sensitivity of positron imaging, higher target background ratio with higher tracer accumulation in bone hydroxyapatite and higher specificity through CT correlation. These properties have also given directions to new research fields based on imaging microcalcifications, very recently. A limited number of cases have reported the F-18 NaF uptake in macrocalcified soft tissue metastases. Although the presence of microcalcification was not proved; accumulation of F-18 NaF in the metastatic brain lesion with no visible calcification on the CT, in a patient with ductal breast carcinoma has also been reported...
December 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29238011/plaque-calcification-during-atherosclerosis-progression-and-regression
#10
Atsushi Shioi, Yuji Ikari
Plaque calcification develops by the inflammation-dependent mechanisms involved in progression and regression of atherosclerosis. Macrophages can undergo two distinct polarization states, that is, pro-inflammatory M1 phenotype in progression and anti-inflammatory M2 phenotype in regression. In plaque progression, predominant M1 macrophages promote the initial calcium deposition within the necrotic core of the lesions, called as microcalcification, through not only vesicle-mediated mineralization as the result of apoptosis of macrophages and vascular smooth muscle cells (VSMCs), but also VSMC differentiation into early phase osteoblasts...
December 12, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29224890/advances-in-breast-intervention-where-are-we-now-and-where-should-we-be
#11
REVIEW
W B G Sanderink, R M Mann
In the past four decades, a variety of methods for minimal or non-invasive diagnosis and treatment of breast cancer have been introduced. Although breast imaging has become more and more specific for diagnosis, specimen biopsy with histopathological confirmation is still necessary. Core-needle biopsy under ultrasound guidance is the appropriate first choice for the diagnosis of most lesions. Fine-needle aspiration is of interest for identification of the presence of metastatic disease in abnormal lymph nodes...
December 7, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/29221896/correlative-imaging-reveals-physiochemical-heterogeneity-of-microcalcifications-in-human-breast-carcinomas
#12
Jennie A M R Kunitake, Siyoung Choi, Kayla X Nguyen, Meredith M Lee, Frank He, Daniel Sudilovsky, Patrick G Morris, Maxine S Jochelson, Clifford A Hudis, David A Muller, Peter Fratzl, Claudia Fischbach, Admir Masic, Lara A Estroff
Microcalcifications (MCs) are routinely used to detect breast cancer in mammography. Little is known, however, about their materials properties and associated organic matrix, or their correlation to breast cancer prognosis. We combine histopathology, Raman microscopy, and electron microscopy to image MCs within snap-frozen human breast tissue and generate micron-scale resolution correlative maps of crystalline phase, trace metals, particle morphology, and organic matrix chemical signatures within high grade ductal carcinoma in situ (DCIS) and invasive cancer...
December 5, 2017: Journal of Structural Biology
https://www.readbyqxmd.com/read/29211402/sonographic-patterns-of-peyronie-s-disease-in-patients-with-absence-of-palpable-plaques
#13
Lucio Dell'Atti, Andrea Benedetto Galosi
PURPOSE: Non-palpable isolated septal plaques of the penis are likely present in a significant number of patients affected by erectile dysfunction (ED) and penile pain without deformity or curvature. The aim of this study was to evaluate the ultrasound (US) patterns observed in patients investigated for ED or penile pain without curvature. MATERIALS AND METHODS: We reviewed the medical records of 386 patients who underwent an initial colour-Doppler ultrasonography (CDU) of the penis for DE and/or penile pain without curvature...
December 7, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29210533/rapid-differential-diagnosis-of-breast-microcalcification-using-targeted-near-infrared-fluorophores
#14
Min Ho Park, Wonbong Lim, Danbi Jo, Jin Seok Jung, Subin Kim, Jangho Kim, Hyo Soon Lim, Ji Shin Lee, Jung-Joon Min, Hoon Hyun
Early detection and differential diagnosis of breast microcalcifications are of significant importance in effective treatment of early breast cancer, because mineral composition of breast calcification is directly associated with different pathological states. However, applying image-based modalities for component identification in breast calcification remains challenging, because no calcification-specific contrast agent is available to distinguish between benign and malignant (type I and type II, respectively) calcifications of breast lesions...
December 6, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29191685/breast-mri-as-a-problem-solving-study-in-the-evaluation-of-bi-rads-categories-3-and-4-microcalcifications-is-it-worth-performing
#15
Akiko Shimauchi, Youichi Machida, Ichiro Maeda, Eisuke Fukuma, Kazuei Hoshi, Mitsuhiro Tozaki
RATIONALE AND OBJECTIVES: We aimed to investigate the utility of problem-solving breast magnetic resonance imaging (MRI) for mammographic Breast Imaging Reporting and Data System (BI-RADS) categories 3 and 4 microcalcifications. MATERIALS AND METHODS: Between January 1, 2010 and December 31, 2011, 138 women with 146 areas of categories 3 and 4 microcalcifications without sonographic correlates underwent breast MRI and had a stereotactic core biopsy using an 11-gauge needle or follow-up at least for 24 months...
November 27, 2017: Academic Radiology
https://www.readbyqxmd.com/read/29190656/mri-for-the-assessment-of-malignancy-in-bi-rads-4-mammographic-microcalcifications
#16
Barbara Bennani-Baiti, Matthias Dietzel, Pascal A Baltzer
PURPOSE: Assess the performance of breast MRI to diagnose breast cancer in BI-RADS 4 microcalcifications detected by mammography. MATERIALS AND METHODS: This retrospective, IRB-approved study included 248 consecutive contrast-enhanced breast MRI (1.5T, protocol in accordance with EUSOBI recommendations) performed to further diagnose BI-RADS 4 microcalcifications detected at mammography during a 3-year period. Standard of reference had to be established by histopathology...
2017: PloS One
https://www.readbyqxmd.com/read/29176921/foveated-model-observers-to-predict-human-performance-in-3d-images
#17
Miguel A Lago, Craig K Abbey, Miguel P Eckstein
We evaluate 3D search requires model observers that take into account the peripheral human visual processing (foveated models) to predict human observer performance. We show that two different 3D tasks, free search and location-known detection, influence the relative human visual detectability of two signals of different sizes in synthetic backgrounds mimicking the noise found in 3D digital breast tomosynthesis. One of the signals resembled a microcalcification (a small and bright sphere), while the other one was designed to look like a mass (a larger Gaussian blob)...
February 11, 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/29176920/the-role-of-extra-foveal-processing-in-3d-imaging
#18
Miguel P Eckstein, Miguel A Lago, Craig K Abbey
The field of medical image quality has relied on the assumption that metrics of image quality for simple visual detection tasks are a reliable proxy for the more clinically realistic visual search tasks. Rank order of signal detectability across conditions often generalizes from detection to search tasks. Here, we argue that search in 3D images represents a paradigm shift in medical imaging: radiologists typically cannot exhaustively scrutinize all regions of interest with the high acuity fovea requiring detection of signals with extra-foveal areas (visual periphery) of the human retina...
February 11, 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/29169230/ultrasonographic-features-of-pure-ductal-carcinoma-italic-in-situ-italic-of-the-breast-correlations-with-pathologic-features-and-biological-markers
#19
Hwajin Cha, Yun-Woo Chang, Eun Ji Lee, Ji Young Hwang, Hyun Joo Kim, Eun Hye Lee, Jung Kyu Ryu
Purpose: The purpose of this study was to evaluate the ultrasonographic features of pure ductal carcinoma in situ (DCIS) of the breast and to evaluate the correlations of ultrasonographic features with pathologic and biological features. Methods: A total of 141 lesions in 138 women with pure DCIS who underwent preoperative breast ultrasonography were retrospectively reviewed. Ultrasonographic features were analyzed using the American College of Radiology Breast Imaging Reporting and Data System (BI-RADS) ultrasonography lexicon and the diagnostic criteria of the Japan Society of Ultrasonics in Medicine...
October 13, 2017: Ultrasonography
https://www.readbyqxmd.com/read/29162407/a-predictive-model-to-distinguish-malignant-and-benign-thyroid-nodules-based-on-age-gender-and-ultrasonographic-features
#20
Fábio Muradás Girardi, Laura Mezzomo da Silva, Cecilia Dias Flores
INTRODUCTION: A discussion in literature about a standardized decision support tool for the management of thyroid nodules remains. OBJECTIVE: The purpose of this study was to create a statistical prediction model for thyroid nodules management. METHODS: Two hundred and four benign and 57 malignant thyroid nodules were selected for a retrospective study. The variables age, gender and ultrasonographic features were examined using univariate and multivariate models...
November 4, 2017: Brazilian Journal of Otorhinolaryngology
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