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uterine inversion

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https://www.readbyqxmd.com/read/29763885/intrauterine-growth-restriction-affects-cerebellar-granule-cells-in-the-developing-guinea-pig-brain
#1
Mary Tolcos, Annie McDougall, Amy Shields, Yoonyoung Chung, Rachael O'Dowd, Ann Turnley, Megan Wallace, Sandra Rees
Intrauterine growth restriction (IUGR) can lead to adverse neurodevelopmental sequelae in postnatal life. However, the effects of IUGR on the cerebellum are still to be fully elucidated. A major determinant of growth and development of the cerebellum is proliferation and subsequent migration of cerebellar granule cells. Our objective was to determine whether IUGR, induced by chronic placental insufficiency (CPI) in guinea pigs, results in abnormal cerebellar development due to deficits suggestive of impaired granule cell proliferation and/or migration...
May 15, 2018: Developmental Neuroscience
https://www.readbyqxmd.com/read/29600404/differential-gene-expression-of-extracellular-matrix-related-proteins-in-the-vaginal-apical-compartment-of-women-with-pelvic-organ-prolapse
#2
Haijiao Wang, Yukimi Kira, Akihiro Hamuro, Aki Takase, Daisuke Tachibana, Masayasu Koyama
INTRODUCTION AND HYPOTHESIS: Pelvic organ prolapse (POP) is a multifactorial disorder that impairs the quality of life (QoL) of older women in particular. The purpose of this study was to elucidate the pathogenesis of POP by focusing on the extracellular matrix (ECM). METHODS: Patients were classified into two groups-with or without cervical elongation-using the POP quantification system. Specimens were obtained from 29 women with POP during hysterectomy. The expression of fibulin-5, elastin, integrin β1 (ITGβ1), lysyl oxidase-like protein-1 (LOXL1) and collagen in the vagina, uterosacral ligament, and uterine cervix was investigated by quantitative real-time polymerase chain reaction (RT-PCR) and correlation between gene levels and severity of POP examined...
March 29, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29588826/relationship-between-behavioral-indices-of-pain-during-labor-pain-with-pain-intensity-and-duration-of-delivery
#3
Bibi Marziyeh Hashemi Asl, Atiyeh Vatanchi, Nahid Golmakani, Alireza Najafi
Background: Certain behaviors can be adopted by women to cope with labor pain according to their individual characteristics, which are currently called behavioral indicators during labor pain, and include facial expressions, verbal expressions, tone of voice, body movements, degree of relaxation, and respiratory system functioning during delivery. Moreover, severity of pain and duration of labor can vary due to several factors including individual characteristics. Objective: The purpose of the present study was to determine the relationship between behavioral indicators during labor pain, severity of pain, and delivery duration...
January 2018: Electronic Physician
https://www.readbyqxmd.com/read/29573498/correlation-between-fetoplacental-dopplers-and-cardiac-function-in-term-fetuses
#4
Amal A Alsolai, Larissa N Bligh, Ristan M Greer, Sailesh Kumar
OBJECTIVE: Redistribution of cardiac output is responsible for the "brain sparing" effect seen during periods of fetal stress. Our aim was to prospectively investigate the correlation between feto-placental Dopplers and cardiac function. METHODS: This prospective, observational study included normotensive women with appropriately grown, non-anomalous, singleton pregnancies. Participants underwent fortnightly ultrasounds from 36 weeks' gestation and intrapartum and neonatal outcomes were recorded...
March 24, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29504731/expression-of-matrix-metalloproteinase-enzymes-in-endometrium-of-women-with-abnormal-uterine-bleeding
#5
Barbara Grzechocinska, Filip A Dabrowski, Marcin Chlebus, Agata Gondek, Katarzyna Czarzasta, Lukasz Michalowski, Agnieszka Cudnoch-Jedrzejewska, Miroslaw Wielgos
OBJECTIVES: Abnormal uterine bleeding (AUB) is caused by derangement of physiological processes of tissue growth, shedding and regeneration. It is known that interplay between metalloproteinases (MMP's) and tissue inhibitors of metalloproteinases (TIMP's) may play a crucial role in its occurrence. AIM: To define if expression of proMMP-2, MMP-2 and TIMP-1 in endometrium of women with AUB is dependent on steroid sex hormone concentration and histopathological picture...
February 2018: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29504179/high-signal-in-bone-marrow-on-diffusion-weighted-imaging-of-female-pelvis-correlation-with-anemia-and-fibroid-associated-symptoms
#6
Ying-Yuan Chen, Ching-Lan Wu, Shu-Huei Shen
BACKGROUND: The diffusion-weighted imaging (DWI) signals of the female pelvic bone marrow show great variability and are usually high in female patients with fibroid-associated symptoms and anemia. PURPOSE: To ascertain clinical factors contributing to high signal intensity in the bone marrow of the female pelvis on DWI. STUDY TYPE: Retrospective case-control study. SUBJECTS: A single-institution review of 221 female patients underwent a pelvic magnetic resonance study from December 2012 to July 2014...
March 5, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29430980/chronic-non-puerperal-uterine-inversion-in-an-asymptomatic-woman
#7
Tânia Lima, Rita Sousa, Angelina Pinheiro, Amélia Almeida
No abstract text is available yet for this article.
February 12, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29416878/genomic-profiling-identifies-gpc5-amplification-in-association-with-sarcomatous-transformation-in-a-subset-of-uterine-carcinosarcomas
#8
M Herman Chui, Cherry Have, Lien N Hoang, Patricia Shaw, Cheng-Han Lee, Blaise A Clarke
Uterine carcinosarcoma, also known as Malignant Mixed Müllerian Tumour, is a high-grade biphasic neoplasm composed of sarcomatous elements thought to originate via transdifferentiation from high-grade endometrial carcinoma. To identify molecular factors contributing to the histogenesis of this tumour, we analyzed DNA extracted from matched carcinoma and sarcoma components from 12 cases of carcinosarcoma by a molecular inversion probe microarray to assess genomic copy number alterations (CNAs) and allelic imbalances...
January 2018: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/29415736/uterine-foxl2-regulates-the-adherence-of-the-trophectoderm-cells-to-the-endometrial-epithelium
#9
Michal Elbaz, Ron Hadas, Louise M Bilezikjian, Eran Gershon
BACKGROUND: Forkhead Transcription Factor L2 (FOXL2) is a member of the forkhead family with important roles in reproduction. Recent studies showed that FOXL2 is expressed in human and bovine endometrium and that its levels fluctuate during pregnancy. In this study, we aimed at evaluating the expression and function of FOXL2 in embryo implantation. METHODS: Mouse uteri at different days of pregnancy were isolated and analyzed for the expression and localization of FOXL2...
February 7, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29409562/birth-weight-is-associated-with-dietary-factors-at-the-age-of-6-8-years-the-physical-activity-and-nutrition-in-children-panic-study
#10
Aino-Maija Eloranta, Jarmo Jääskeläinen, Taisa Venäläinen, Henna Jalkanen, Sanna Kiiskinen, Aino Mäntyselkä, Ursula Schwab, Virpi Lindi, Timo A Lakka
OBJECTIVE: Low and high birth weight have been associated with increased risk of type 2 diabetes and CVD. Diet could partly mediate this association, e.g. by intra-uterine programming of unhealthy food preferences. We examined the association of birth weight with diet in Finnish children. DESIGN: Birth weight standard deviation score (SDS) was calculated using national birth register data and Finnish references. Dietary factors were assessed using 4 d food records...
May 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29402239/primary-extra-uterine-and-extra-ovarian-mullerian-adenosarcoma-case-report-and-literature-review
#11
Vincenzo Dario Mandato, Federica Torricelli, Valentina Mastrofilippo, Riccardo Valli, Lorenzo Aguzzoli, Giovanni Battista La Sala
BACKGROUND: Extra-uterine mullerian adenosarcomas have varying biological behaviours depending on the presence of endometriosis or sarcomatous overgrowth. These behaviours manifest according to the tumours' histological characteristics and sites of origin. The best treatment and oncologic outcome have not been clarified because only a few cases of extra-uterine and extra-ovarian adenosarcoma have been described in the literature. Here, we report a case of primary peritoneal adenosarcoma with sarcomatous overgrowth and review all reported cases of adenosarcomas arising outside of the uterus and outside the ovaries to identify the best treatment options and clarify outcomes...
February 5, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29390463/a-double-blinded-randomized-placebo-controlled-trial-assessing-the-effects-of-nifedipine-on-embryo-transfer-study-protocol
#12
RANDOMIZED CONTROLLED TRIAL
Kelvin Kl Ng, Genia Rozen, Tanya Stewart, Franca Agresta, Alex Polyakov
INTRODUCTION: Implantation failure is the main factor affecting the success rate of in vitro fertilization (IVF) procedures. Studies have reported that uterine contractions (UCs) at the time of embryo transfer (ET) were inversely related to implantation and pregnancy rate, hence reducing the success of IVF treatment. Various pharmacological agents, with the exception of calcium channel blocker (CCB), have been investigated to reduce UC. In this regard, we are presenting a proposal for a double-blind randomized placebo-controlled trial...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29378741/chronic-incomplete-non-puerperal-uterine-inversion-due-to-huge-submucous-fibroid-diagnosis-and-management
#13
Nourah Hasan Al Qahtani
No abstract text is available yet for this article.
January 29, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29318732/association-between-fetal-fraction-on-cell-free-dna-testing-and-first-trimester-markers-for-pre-eclampsia
#14
Daniel L Rolnik, Fabricio da Silva Costa, Timothy J Lee, Maximilian Schmid, Andrew C McLennan
AIMS: To evaluate the association of fetal fraction on cell-free DNA (cfDNA) testing with first trimester markers for pre-eclampsia and to investigate a possible association of low fetal fraction with increased risk for pre-eclampsia (PE) and fetal growth restriction (FGR). METHODS: This was a retrospective cohort study including all women with singleton pregnancies who had risk calculation for PE and FGR between 11+0 and 13+6 weeks' gestation and also decided to have cfDNA as a primary or secondary screening test for chromosomal abnormalities at any gestational age in two Fetal Medicine clinics in Sydney and Melbourne, Australia, between March 2013 and May 2017...
January 10, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29304224/in-vitro-differentiation-of-human-oocyte-like-cells-from-oogonial-stem-cells-single-cell-isolation-and-molecular-characterization
#15
Erica Silvestris, Paola Cafforio, Stella D'Oronzo, Claudia Felici, Franco Silvestris, Giuseppe Loverro
STUDY QUESTION: Are the large cells derived from cultured DEAD box polypeptide 4 (DDX4)-positive oogonial stem cells (OSCs), isolated from the ovarian cortex of non-menopausal and menopausal women, oocyte-like cells? SUMMARY ANSWER: Under appropriate culture conditions, DDX4-positive OSCs from non-menopausal and menopausal women differentiate into large haploid oocyte-like cells expressing the major oocyte markers growth differentiation factor 9 (GDF-9) and synaptonemal complex protein 3 (SYCP3) and then enter meiosis...
January 3, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29285283/diffusion-weighted-mri-derived-adc-values-reflect-collagen-i-content-in-pdx-models-of-uterine-cervical-cancer
#16
Anette Hauge, Catherine S Wegner, Jon-Vidar Gaustad, Trude G Simonsen, Lise Mari K Andersen, Einar K Rofstad
Apparent diffusion coefficient (ADC) values derived from diffusion-weighted magnetic resonance imaging (DW-MRI) are known to reflect the cellular environment of biological tissues. However, emerging evidence accentuates the influence of stromal elements on ADC values. The current study sought to elucidate whether a correlation exists between ADC and the fraction of collagen I-positive tissue across different tumor models of uterine cervical cancer. Early and late generation tumors of four patient-derived xenograft (PDX) models of squamous cell carcinoma (BK-12, ED-15, HL-16, and LA-19) were included...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29277272/classics-revisited-miguel-fern%C3%A3-ndez-on-germ-layer-inversion-and-specific-polyembryony-in-armadillos
#17
REVIEW
A M Carter
BACKGROUND: Miguel Fernández was an Argentinian zoologist who published the first account of obligate polyembryony in armadillos. His contribution is here discussed in relation to his contemporaries, Newman and Patterson, and more recent work. FINDINGS: Fernandez worked on the mulita (Dasypus hybridus). He was able to get early stages before twinning occurred and show it was preceded by inversion of the germ layers. By the primitive streak stage there were separate embryonic shields and partition of the amnion...
January 2018: Placenta
https://www.readbyqxmd.com/read/29243125/minichromosome-maintenance-complex-component-6-mcm6-expression-correlates-with-histological-grade-and-survival-in-endometrioid-endometrial-adenocarcinoma
#18
Judicaël Hotton, Mikaël Agopiantz, Agnès Leroux, Claire Charra-Brunaud, Béatrice Marie, Hélène Busby-Venner, Olivier Morel, Jean-Louis Guéant, Jean-Michel Vignaud, Shyue-Fang Battaglia-Hsu, Guillaume Gauchotte
Minichromosome maintenance complex component 6 (MCM6) is involved in initiating DNA replication and is upregulated during licensed G0 phase of the cell cycle. This early expression permits its labeling of more proliferating cells than those by Ki-67. Here using a cohort of 89 endometrioid adenocarcinoma, we report findings made on the prognostic value of MCM6 based on immunohistochemical labeling index (LI) of the protein in comparison with that of Ki67 as no such information is currently available. Additionally, we examined the prognostic values of these markers based on their mRNA expression using a cohort of uterine corpus endometrial carcinoma (UCEC, n = 307) taken from The Cancer Genome Atlas (TCGA) database...
December 14, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29202956/admixture-mapping-of-uterine-fibroid-size-and-number-in-african-american-women
#19
MULTICENTER STUDY
Michael J Bray, Todd L Edwards, Melissa F Wellons, Sarah H Jones, Katherine E Hartmann, Digna R Velez Edwards
OBJECTIVE: To evaluate the relationship between genetic ancestry and uterine fibroid characteristics. DESIGN: Cross-sectional study. SETTING: Not applicable. PATIENT(S): A total of 609 African American participants with image- or surgery-confirmed fibroids in a biorepository at Vanderbilt University electronic health record biorepository and the Coronary Artery Risk Development in Young Adults studies were included. INTERVENTION(S): None...
December 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/29100521/dce-mri-of-patient-derived-xenograft-models-of-uterine-cervix-carcinoma-associations-with-parameters-of-the-tumor-microenvironment
#20
Anette Hauge, Catherine S Wegner, Jon-Vidar Gaustad, Trude G Simonsen, Lise Mari K Andersen, Einar K Rofstad
BACKGROUND: Abnormalities in the tumor microenvironment are associated with resistance to treatment, aggressive growth, and poor clinical outcome in patients with advanced cervical cancer. The potential of dynamic contrast-enhanced (DCE) MRI to assess the microvascular density (MVD), interstitial fluid pressure (IFP), and hypoxic fraction of patient-derived cervical cancer xenografts was investigated in the present study. METHODS: Four patient-derived xenograft (PDX) models of squamous cell carcinoma of the uterine cervix (BK-12, ED-15, HL-16, and LA-19) were subjected to Gd-DOTA-based DCE-MRI using a 7...
November 3, 2017: Journal of Translational Medicine
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