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https://www.readbyqxmd.com/read/29100521/dce-mri-of-patient-derived-xenograft-models-of-uterine-cervix-carcinoma-associations-with-parameters-of-the-tumor-microenvironment
#1
Anette Hauge, Catherine S Wegner, Jon-Vidar Gaustad, Trude G Simonsen, Lise Mari K Andersen, Einar K Rofstad
BACKGROUND: Abnormalities in the tumor microenvironment are associated with resistance to treatment, aggressive growth, and poor clinical outcome in patients with advanced cervical cancer. The potential of dynamic contrast-enhanced (DCE) MRI to assess the microvascular density (MVD), interstitial fluid pressure (IFP), and hypoxic fraction of patient-derived cervical cancer xenografts was investigated in the present study. METHODS: Four patient-derived xenograft (PDX) models of squamous cell carcinoma of the uterine cervix (BK-12, ED-15, HL-16, and LA-19) were subjected to Gd-DOTA-based DCE-MRI using a 7...
November 3, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29035799/use-of-the-endometriosis-fertility-index-in-daily-practice-a-prospective-evaluation
#2
J Boujenah, I Cedrin-Durnerin, C Herbemont, A Bricou, C Sifer, C Poncelet
OBJECTIVE: To perform a prospective evaluation of postoperative fertility management using the endometriosis fertility index (EFI). STUDY: This prospective non-interventional observational study was performed from January 2013 to February 2016 in a tertiary care university hospital and an assisted reproductive technology (ART) centre. In total, 196 patients underwent laparoscopic surgery for endometriosis-related infertility. Indications for surgery included pelvic pain (dysmenorrhoea, and/or deep dyspareunia), abnormal hysterosalpingogram, and failure to conceive after three or more superovulation cycles with or without intra-uterine insemination...
October 10, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29022494/colder-environments-are-associated-with-a-greater-cancer-incidence-in-the-female-population-of-the-united-states
#3
Ankit Sharma, Tanu Sharma, Mahaveer S Panwar, Devesh Sharma, Rashmi Bundel, Ryan T Hamilton, James A Radosevich, Chandi C Mandal
Cancer incidence and/or mortality among individuals varies with diet, socio-culture, ethnicity, race, gender, and age. Similarly, environmental temperature modulates many biological functions. To study the effect of environment temperature on cancer incidence, the US population was selected. Because, county-wise cancer incidence rate data of various anatomical site-specific cancers and different races/ethnicities for both males and females are available. Moreover, the differences amongst the aforementioned factors among individuals are much less, as compared to the world population...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28919598/risk-factors-and-immediate-outcome-of-very-low-birth-weight-babies-appropriate-for-gestational-age-in-newly-established-scanu-mymensingh-medical-college-hospital
#4
K Begum, M N Islam, M A Hossain, M A Ali, M K Islam, M A Islam, M Salim, M Oliullah
Low birth weight (LBW) is the most important preventable cause in the neonatal period leading to very high neonatal mortality and morbidity in developing countries like Bangladesh. A cross sectional study was conducted in the neonatology ward, Mymensingh Medical College Hospital, Mymensingh from July 2014 to December 2014 to identify the risk factors and immediate hospital outcome of Very Low Birth Weight (VLBW) Appropriate for Gestational Age (AGA) babies in context of present neonatal hospital care standard...
July 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28829815/effect-of-vitamin-e-supplementation-on-uterine-cervical-neoplasm-a-meta-analysis-of-case-control-studies
#5
Xiaoli Hu, Saisai Li, Lulu Zhou, Menghuang Zhao, Xueqiong Zhu
Several epidemiological studies have suggested that vitamin E could reduce the risk of uterine cervical neoplasm. However, controversial data were presented by different reports. Hence, we conducted a meta-analysis to assess the relationship between vitamin E and the risk of cervical neoplasia. We performed a comprehensive search of the PubMed, Embase and Cochrane databases through December 31, 2016. Based on a fixed-effects or random-effects model, the odds ratio (OR) and 95% confidence intervals (CIs) were calculated to assess the combined risk...
2017: PloS One
https://www.readbyqxmd.com/read/28783853/uterine-artery-doppler-velocimetry-of-uterine-leiomyomas-in-nigerian-women
#6
Bukunmi Michael Idowu, Bolanle Olubunmi Ibitoye, Victor Adebayo Adetiloye
Objective To describe the blood flow velocities and impedance indices changes in the uterine arteries of leiomyomatous uteri using Doppler sonography. Methods This was a prospective, case-control study conducted on 140 premenopausal women with sonographic diagnosis of uterine leiomyoma and 140 premenopausal controls without leiomyomas. Pelvic sonography was performed to diagnose and characterize the leiomyomas. The hemodynamics of the ascending branches of both main uterine arteries was assessed by Doppler interrogation...
September 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28706412/uterine-adenofibroma-an-unsual-cause-of-nonpuerperal-uterine-inversion-in-postmenopausal-female
#7
Latika Chawla, Richa Vatsa, Kallol Kumar Roy, Sunesh Kumar
Uterine adenofibroma is an extremely rare benign mixed mullerian tumor, most often presenting as vaginal mass with pain and abnormal uterine bleeding in postmenopausal females. Nonpuerperal uterine inversion is also an uncommon entity. We present a rare case of nonpuerperal uterine inversion due to a uterine adenofibroma. A 56-year-old postmenopausal female presented to us with bleeding and discharge per vaginum. Examination showed a polyp. Due to associated comorbidities, polypectomy was chosen as management modality failing which laparotomy was done, and the uterus was found to be inverted through the cervix, hysterectomy was done...
April 2017: Journal of Mid-life Health
https://www.readbyqxmd.com/read/28689682/vaginal-versus-robotic-hysterectomy-for-commonly-cited-relative-contraindications-to-vaginal-hysterectomy
#8
Jennifer J Schmitt, John A Occhino, Amy L Weaver, Michaela E McGree, John B Gebhart
STUDY OBJECTIVE: To compare outcomes of vaginal hysterectomy (VH) and robotic-assisted hysterectomy (RH) among women with conditions perceived as contraindications to VH (uterine size ≥ 12 weeks' gestation, no vaginal parity, prior cesarean delivery, and obesity). DESIGN: Retrospective chart review (Canadian Task Force classification II-2). SETTING: Tertiary US medical center. PATIENTS: Women with VH or RH. Women with conditions perceived as contraindications affecting surgical choice were excluded...
November 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28637238/chlamydia-trachomatis-seroprevalence-and-ultrasound-diagnosed-uterine-fibroids-in-a-large-population-of-young-african-american-women
#9
Kristen R Moore, Jennifer S Smith, Stephen R Cole, Dirk P Dittmer, Victor J Schoenbach, Donna D Baird
Reproductive tract infections have long been hypothesized to increase fibroid risk. Few studies have been conducted, even for the common infection, genital Chlamydia trachomatis (gCT), and only with self-reported gCT data. Our investigation used micro-immunofluorescence serology for gCT to characterize past exposure. We used cross-sectional enrollment data from a prospective fibroid study in the Detroit, Michigan area; ultrasound examinations systematically screened for fibroids. Participants were African-American women ages 23-34 (recruited 2010-2012)...
June 16, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28585847/-uterine-inversion
#10
L Mužná, R Pilka
AIM: Summarize the literature on the inversion of the uterus. DESIGN: A review article. SETTING: Department of Obstetrics and Gynecology, SZZ Krnov, Department of Obstetrics and Gynecology, University Hospital, Palacky University, Olomouc. METHOD: Literature review was conducted using the following key words. There were included articles published in English since 1980, from which relevant data were obtained. RESULTS: In the literature the general occurrence is broad, ranging from 1:27 000 in the UK to 1:1739 in the US, where it varies greatly according to geographic location...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/28578177/the-impact-of-uterine-immaturity-on-obstetrical-syndromes-during%C3%A2-adolescence
#11
Ivo Brosens, Joanne Muter, Caroline E Gargett, Patrick Puttemans, Giuseppe Benagiano, Jan J Brosens
Pregnant nulliparous adolescents are at increased risk, inversely proportional to their age, of major obstetric syndromes, including preeclampsia, fetal growth restriction, and preterm birth. Emerging evidence indicates that biological immaturity of the uterus accounts for the increased incidence of obstetrical disorders in very young mothers, possibly compounded by sociodemographic factors associated with teenage pregnancy. The endometrium in most newborns is intrinsically resistant to progesterone signaling, and the rate of transition to a fully responsive tissue likely determines pregnancy outcome during adolescence...
November 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28533481/massively-parallel-sequencing-and-genome-wide-copy-number-analysis-revealed-a-clonal-relationship-in-benign-metastasizing-leiomyoma
#12
Ren-Chin Wu, An-Shine Chao, Li-Yu Lee, Gigin Lin, Shu-Jen Chen, Yen-Jung Lu, Huei-Jean Huang, Chi-Feng Yen, Chien Min Han, Yun-Shien Lee, Tzu-Hao Wang, Angel Chao
Benign metastasizing leiomyoma (BML) is a rare disease entity typically presenting as multiple extrauterine leiomyomas associated with a uterine leiomyoma. It has been hypothesized that the extrauterine leiomyomata represent distant metastasis of the uterine leiomyoma. To date, the only molecular evidence supporting this hypothesis was derived from clonality analyses based on X-chromosome inactivation assays. Here, we sought to address this issue by examining paired specimens of synchronous pulmonary and uterine leiomyomata from three patients using targeted massively parallel sequencing and molecular inversion probe array analysis for detecting somatic mutations and copy number aberrations...
July 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28522320/risks-and-consequences-of-puerperal-uterine-inversion-in-the-united-states-2004-through-2013
#13
Sarah L Coad, Leanne S Dahlgren, Jennifer A Hutcheon
BACKGROUND: Puerperal uterine inversion is a rare, potentially life-threatening obstetrical emergency. The current literature consists of small case series and a single nationwide study from Europe with only 15 cases. OBJECTIVE: We aimed to define the incidence, temporal trends, and outcomes in women with uterine inversion using a nationally representative US cohort. STUDY DESIGN: We used the Nationwide Inpatient Sample, a 20% sample of US hospital admissions, to identify all deliveries from 2004 through 2013...
September 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28471130/non-puerperal-uterine-inversion-due-to-submucous-myoma-in-a-woman-a-case-report
#14
Ayse Kirbas, Korkut Daglar, Ozgur Kara, Ayhan Sucak, Turhan Caglar
Uterine leiomyomas are the most common benign tumor of the female reproductive tract. Their incidence during pregnancy is approximately 2 percent and they are associated with some complications such as preterm labor, placental abruption, fetal malpresentation, obstructed labor, cesarean delivery, and postpartum hemorrhage. They may develop anywhere within the muscular wall of the uterus, including submucosal, intramural, or subserosal areas. Some of the submucous myomas may be pedunculated and eventually may protrude through the cervical canal to the vagina...
July 2016: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28467127/markers-of-obesity-and-growth-in-preeclamptic-and-normotensive-pregnant-women
#15
S Kharb, J Bala, S Nanda
The objective of the study was to analyse leptin, IGF-1, Apo A, lipoproteins, haem oxygenase-1 (HO-1) in maternal sera and venous umbilical cord sera of newborn babies of 25 preeclamptics (group II), and 25 normotensive pregnant women (group I) as markers of obesity and growth in preeclamptic and normotensive pregnant women. Apo A I and II levels were estimated by competitive immunoassay using direct chemiluminiscence technology. Haem oxygenase-1 (HO-1), leptin and IGF-1 were analysed by ELISA. Maternal and cord blood levels of homocysteine, folic acid, lipid profile (namely, total cholesterol, triglycerides, LDL-C, VLDL-C and HDL-C), Haem oxygenase 1 were higher in preeclamptic women as compared to normotensive pregnant women...
May 3, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28452161/perinatal-outcome-and-placental-apoptosis-in-patients-with-late-onset-pre-eclampsia-and-abnormal-uterine-artery-doppler-at-diagnosis
#16
Marcelo Rodríguez, Constanza Couve-Pérez, Sebastián San Martín, Felipe Martínez, Carlo Lozano, Alvaro Sepúlveda-Martínez
OBJECTIVE: To determine the rate of placental apoptosis and adverse perinatal outcome in patients with late pre-eclampsia and altered uterine artery (UtA) Doppler. METHODS: A cohort study was performed. Patients with a diagnosis of late pre-eclampsia (l-PE) were stratified according to the UtA Doppler status at diagnosis (below or above the 95(th) percentile). A logistic regression analysis was performed to identify the association between an abnormal UtA Doppler and the presence of adverse maternal and perinatal outcomes...
April 28, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28432313/multiple-clinical-characteristics-separate-med12-mutation-positive-and-negative-uterine-leiomyomas
#17
Hanna-Riikka Heinonen, Annukka Pasanen, Oskari Heikinheimo, Tomas Tanskanen, Kimmo Palin, Jaana Tolvanen, Pia Vahteristo, Jari Sjöberg, Esa Pitkänen, Ralf Bützow, Netta Mäkinen, Lauri A Aaltonen
Up to 86% of uterine leiomyomas harbour somatic mutations in mediator complex subunit 12 (MED12). These mutations have been associated with conventional histology, smaller tumour size, and larger number of tumours within the uterus. Prior studies, with limited sample sizes, have failed to detect associations between other clinical features and MED12 mutations. Here, we prospectively collected 763 uterine leiomyomas and the corresponding normal myometrial tissue from 244 hysterectomy patients, recorded tumour characteristics, collected clinical data from medical records, and screened the tissue samples for MED12 mutations to assess potential associations between clinical variables and mutation status...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28412086/tocolysis-after-preterm-premature-rupture-of-membranes-and-neonatal-outcome-a-propensity-score-analysis
#18
Elsa Lorthe, François Goffinet, Stéphane Marret, Christophe Vayssiere, Cyril Flamant, Mathilde Quere, Valérie Benhammou, Pierre-Yves Ancel, Gilles Kayem
BACKGROUND: There are conflicting results regarding tocolysis in cases of preterm premature rupture of membranes. Delaying delivery may reduce neonatal morbidity because of prematurity and allow for prenatal corticosteroids and, if necessary, in utero transfer. However, that may increase the risks of maternofetal infection and its adverse consequences. OBJECTIVE: The objective of the study was to investigate whether tocolytic therapy in cases of preterm premature rupture of membranes is associated with improved neonatal or obstetric outcomes...
August 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28409600/postpartum-hemorrhage-prevention-and-treatment
#19
Ann Evensen, Janice M Anderson, Patricia Fontaine
Postpartum hemorrhage is common and can occur in patients without risk factors for hemorrhage. Active management of the third stage of labor should be used routinely to reduce its incidence. Use of oxytocin after delivery of the anterior shoulder is the most important and effective component of this practice. Oxytocin is more effective than misoprostol for prevention and treatment of uterine atony and has fewer adverse effects. Routine episiotomy should be avoided to decrease blood loss and the risk of anal laceration...
April 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/28403951/successful-use-of-a-bakri-tamponade-balloon-in-the-treatment-of-puerperal-uterine-inversion-during-caesarean-section
#20
A J Vivanti, E Furet, J Nizard
Acute puerperal inversion of the uterus is a rare life-threatening obstetric emergency, especially during caesarean section. We present the case of a 30-year-old patient with acute puerperal inversion of the uterus that occurred during placental removal. After a quick reversion of the uterus, an immediate postpartum haemorrhage (PPH) due to massive uterine atony was observed. This atony impacted the whole uterus, with a very thin uterine myometrium. The use of a Bakri Tamponade Balloon use allowed treating extreme uterine atony, immediately stop haemorrhage, and prevent a possible risk of immediate recurrence...
January 2017: Journal of gynecology obstetrics and human reproduction
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