Yawen Zhao, Yang Liu, Tian Tao, Jinshan Zhang, Wenying Guo, Handan Deng, Mengxue Han, Haocong Mo, Xiaohan Tong, Song Lin, Jie Yang, Hening Zhai, Qimeng Wang, Zhengfang Hu, Weizhen Zhang, Hui Chen, Geyang Xu
Ghrelin, produced mainly by gastric X/A-like cells, triggers a hunger signal to the central nervous system to stimulate appetite. It remains unclear whether X/A-like cells sense gastric distention and thus regulate ghrelin production. Here we show that PIEZO1 expression in X/A-like cells decreases in patients with obesity when compared to controls, whereas it increases after sleeve gastrectomy. Male and female mice with specific loss of Piezo1 in X/A-like cells exhibit hyperghrelinaemia and hyperphagia and are more susceptible to overweight...
March 11, 2024: Nature metabolism