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https://www.readbyqxmd.com/read/29790028/stimulus-for-glucagon-like-peptide-1-secretion-in-rats
#1
Yu V Natochin, A V Kutina, A S Marina, E I Shakhmatova
Blood concentration of glucagon-like peptide-1 (GLP-1) increased 5 min after per os administration of water, sodium chloride solution, or glucose solution. Changes in blood osmolality or blood glucose level did not stimulate GLP-1 release. A method of short-term increase in the gastric capacity in rats using an inflating balloon attached to the Foley catheter was developed in order to test the hypothesis that excitation of the upper gastrointestinal tract receptors is a primary signal for the GLP-1 secretion during oral intake of the substances...
March 2018: Doklady Biological Sciences: Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections
https://www.readbyqxmd.com/read/29788877/contribution-of-nrf2-in-gastrointestinal-protection-from-oxidative-injury
#2
Akinori Yanaka
The human gastrointestinal tract is exposed to a variety of toxic agents, such as Helicobacter pylori (H.pylori), nonsteroidal anti-inflammatory drugs (NSAIDs), gastric acid, enteric pathogenic bacteria, excessive auto immune reactions, and chronic mental stresses. These stressors generate free radicals within the gastrointestinal tissues, causing chronic inflammatory diseases, ulcers, cancers, and functional disturbances. Recent studies have demonstrated that some natural food compounds upregulate the nuclear factor erythroid 2-related factor 2-mediated antioxidant system, ameliorating or preventing these disorders...
May 21, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29785121/association-between-angiogenesis-and-cytotoxic-signatures-in-the-tumor-microenvironment-of-gastric-cancer
#3
Yi Feng, Ying Dai, Zhihua Gong, Jia-Nan Cheng, Longhui Zhang, Chengdu Sun, Xianghua Zeng, Qingzhu Jia, Bo Zhu
Background: A suppressive immune microenvironment and pathological angiogenesis are hallmarks of gastric cancer. Theoretically, immune checkpoint inhibitors (ICIs) stimulate pre-primed neoantigen-specific T cells, and antiangiogenic agents then facilitate their infiltration into the tumor niche by promoting vascular normalization. Currently, the interconnections of these two phenotypes and their relevance to the tumor microenvironment (TME) have not been fully characterized in gastric cancer...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29781036/correlation-between-hgf-c-met-and-notch1-signaling-pathways-in-human-gastric-cancer-cells
#4
Kuo-Hung Huang, I-Cheng Sung, Wen-Liang Fang, Chin-Wen Chi, Tien-Shun Yeh, Hsin-Chen Lee, Pen-Hui Yin, Anna Fen-Yau Li, Chew-Wun Wu, Yi-Ming Shyr, Muh-Hwa Yang
In recent decades, research concerning gastric carcinogenesis has rapidly progressed. It is evident that hepatocyte growth factor (HGF) is clinically related to gastric cancer progression and metastasis. In addition, previous studies have found that expression of Notch ligand Jagged1 is correlated with the poor prognosis of gastric cancer. However, the interaction between the HGF/c-Met and Notch1 signaling pathways remains unknown. In the present study, we found that gastric cancer patients with positive c-Met expression exhibited poorer overall survival than patients without c-Met expression (P=0...
May 16, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29780600/fluoroscopic-gastric-peroral-endoscopic-pyloromyotomy-g-poem-in-patients-with-a-failed-gastric-electrical-stimulator
#5
Abhinav Koul, Sunil Dacha, Parit Mekaroonkamol, Xiaoyu Li, Lianyong Li, Nikrad Shahnavaz, Steven Keilin, Field F Willingham, Jennifer Christie, Qiang Cai
Background: Gastric electrical stimulators (GESs) have been used to treat refractory gastroparesis in patients who fail initial therapies such as dietary modifications, control of psychological stressors and pharmacologic treatment. More recently, gastric peroral endoscopic pyloromyotomy (G-POEM) has emerged as a novel endoscopic technique to treat refractory gastroparesis. We present a case series of patients with refractory gastroparesis who failed treatment with an implanted GES that were safely treated with G-POEM performed under fluoroscopy as a salvage therapy...
May 2018: Gastroenterology Report
https://www.readbyqxmd.com/read/29770167/reactive-oxygen-species-mediated-tumor-microenvironment-transformation-the-mechanism-of-radioresistant-gastric-cancer
#6
REVIEW
Huifeng Gu, Tianhe Huang, Yicheng Shen, Yin Liu, Fuling Zhou, Yanxia Jin, Haseeb Sattar, Yongchang Wei
Radioresistance is one of the primary causes responsible for therapeutic failure and recurrence of cancer. It is well documented that reactive oxygen species (ROS) contribute to the initiation and development of gastric cancer (GC), and the levels of ROS are significantly increased in patients with GC accompanied with abnormal expressions of multiple inflammatory factors. It is also well documented that ROS can activate cancer cells and inflammatory cells, stimulating the release of a variety of inflammatory cytokines, which subsequently mediates the tumor microenvironment (TME) and promotes cancer stem cell (CSC) maintenance as well as renewal and epithelial-mesenchymal transition (EMT), ultimately resulting in radioresistance and recurrence of GC...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29767252/colony-stimulating-factor-1-and-colony-stimulating-factor-1-receptor-co-expression-is-associated-with-disease-progression-in-gastric-cancer
#7
Yoshinaga Okugawa, Yuji Toiyama, Takashi Ichikawa, Mikio Kawamura, Hiromi Yasuda, Hiroyuki Fujikawa, Susumu Saigusa, Masaki Ohi, Toshimitsu Araki, Koji Tanaka, Yasuhiro Inoue, Motoyoshi Tanaka, Chikao Miki, Masato Kusunoki
Colony‑stimulating‑factor‑1 (CSF‑1) is a hematopoietic growth factor that exerts its effects through the c‑fms/CSF‑1 receptor (CSF‑1R). The CSF‑1/CSF‑1R axis is thought to be involved in the development of several types of cancer. This study aimed to clarify the clinical and biological significance of the CSF‑1/CSF‑1R axis in gastric cancer (GC). For this purpose, we evaluated CSF‑1 and CSF‑1R expression in GC tissues from 148 patients by RT‑qPCR and immunohistochemistry. The biological roles of the CSF‑1/CSF‑1R axis were investigated by measuring the cell proliferation and migration, and anoikis resistance in a human GC cell line following treatment with recombinant human CSF‑1 and/or CSF‑1R inhibitor...
May 16, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29766781/similar-and-distinct-mechanisms-in-the-protective-processes-of-upper-and-lower-gastrointestinal-tract
#8
K Gyires, Sz B László, B Lázár, Z S Zádori
Gastrointestinal (GI) mucosal integrity is based on the balance of aggressive and protective mechanisms. Mucosal damage may occur when the injurious factors become dominant or the mucosal defensive processes are impaired. The main target of the therapy against GI mucosal injury is the reduction of aggressive factors, however, the therapeutic possibilities for stimulation of mucosal defensive process are rather limited. This overview focuses on the gastric and intestinal mucosal protective mechanisms and discusses the main targets that increase protective process and increase the mucosal resistance to injurious stimuli at pre-epithelial, epithelial and sub-epithelial levels...
May 15, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29762691/diagnostic-accuracy-of-post-acth-challenge-salivary-cortisol-concentrations-for-identifying-horses-with-equine-glandular-gastric-disease
#9
Fay J Sauer, Rupert M Bruckmaier, Alessandra Ramseyer, Beatriz Vidondo, Milena D Scheidegger, Vinzenz Gerber
The aims of this study were to better characterize the adrenal response to i.v. adrenocorticotropic hormone (ACTH) in horses with and without gastric disease and to validate and simplify the ACTH stimulation test by determining the diagnostic accuracy of six consecutive sampling time points after ACTH administration for equine glandular gastric disease (EGGD) and equine squamous gastric disease (ESGD). Twenty-six endurance and eventing horses without clinical disease [Sport Horse Population (SHP)] and an independent population of 62 horses [General Population (GP)] were grouped by gastroscopic findings (no/mild vs...
May 12, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29749407/peripheral-n-methyl-d-aspartate-receptor-localization-and-role-in-gastric-acid-secretion-regulation-immunofluorescence-and-pharmacological-studies
#10
Iuliia Golovynska, Tatiana V Beregova, Tatiana M Falalyeyeva, Ludmila I Stepanova, Sergii Golovynskyi, Junle Qu, Tymish Y Ohulchanskyy
The enteric nervous system (ENS) and a glutamate receptor (GluR), N-methyl-D-aspartate receptor (NMDAR), participate in gastric acid secretion (GAS) regulation. NMDARs are localized in different stomach cells; however, knowledge of NMDAR expression and function in the ENS is limited. In the present study, we clarified the types of stomach cells that express the NMDARs that are involved in GAS regulation. The pharmacological method of isolated stomach perfusion by Ghosh and Shild combined with direct mapping of NMDARs by fluorescence microscopy in the rat stomach was employed...
May 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29748143/the-investigation-and-treatment-of-diabetic-gastroparesis
#11
REVIEW
Mohit Kumar, Adam Chapman, Saad Javed, Uazman Alam, Rayaz A Malik, Shazli Azmi
PURPOSE: This review provides an update on the investigations and treatment options for gastroparesis. METHODS: A comprehensive literature search of Medline, PubMed, Embase and OVID was conducted which included all systematic reviews and research articles that focused on the diagnosis, investigations and management diabetic gastroparesis. FINDINGS: Dietary modifications and pharmacologic treatment with prokinetics to increase gastric motility form the mainstay of treatment...
May 7, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29741131/on-the-distribution-and-metabolism-of-fusarium-toxins-along-the-gastrointestinal-tract-of-endotoxaemic-pigs
#12
Erik Bannert, Tanja Tesch, Jeannette Kluess, Janine Winkler, Jana Frahm, Susanne Kersten, Stefan Kahlert, Lydia Renner, Hermann-Josef Rothkötter, Sven Dänicke
The aim of this study was to investigate the potential modulatory effect of E. coli lipopolysaccharides (LPS) on residues of deoxynivalenol (DON), de-epoxy-deoxynivalenol (DOM-1), zearalenone (ZEN) and its metabolites α-zearalenol (α-ZEL), β-zearalenol (β-ZEL), zearalanone (ZAN), α-zearalanol (α-ZAL) and β-zearalanol (β-ZAL) after pre- or post-hepatic administration along the gastrointestinal axis. Fifteen barrows were exposed to a naturally mycotoxin contaminated diet (4.59 mg DON/kg feed and 0.22 mg ZEN/kg feed) and equipped with jugular (ju) and portal (po) catheters...
June 2018: Archives of Animal Nutrition
https://www.readbyqxmd.com/read/29739973/impaired-neural-pathway-in-gastric-muscles-of-patients-with-diabetes
#13
Yang Won Min, Eun-Ju Ko, Ji-Yeon Lee, Poong-Lyul Rhee
To explore the pathogenic mechanism of diabetic gastropathy, we investigated differences in response to electrical field stimulation (EFS) of gastric muscles from diabetic and non-diabetic (control) patients. Gastric specimens were obtained from 34 patients and 45 controls who underwent gastrectomy for early gastric cancer. Using organ bath techniques, we examined peak and nadir values of contraction under EFS. To examine responses to purinergic and nitrergic inhibition without cholinergic innervation, atropine, MRS2500, and N-nitro-L-arginine (L-NNA) were added sequentially to the organ bath...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29732475/effects-of-acute-nefa-manipulation-on-incretin-induced-insulin-secretion-in-participants-with-and-without-type-2-diabetes
#14
Brenno Astiarraga, Valéria B Chueire, Aglécio L Souza, Ricardo Pereira-Moreira, Sarah Monte Alegre, Andrea Natali, Andrea Tura, Andrea Mari, Ele Ferrannini, Elza Muscelli
AIMS/HYPOTHESIS: Incretin effect-the potentiation of glucose-stimulated insulin release induced by the oral vs the i.v. route-is impaired in dysglycaemic states. Despite evidence from human islet studies that NEFA interfere with incretin function, little information is available about the effect in humans. We tested the impact of acute bidirectional NEFA manipulation on the incretin effect in humans. METHODS: Thirteen individuals with type 2 diabetes and ten non-diabetic volunteers had a 3 h OGTT, and, a week later, an i...
May 7, 2018: Diabetologia
https://www.readbyqxmd.com/read/29729162/interrelation-between-ghrelin-and-gastrin-in-patients-with-combination-of-chronic-gastritis-and-type-2-diabetes-mellitus
#15
Elizaveta S Sirchak, Silviya V Patskun
OBJECTIVE: Introduction: Ghrelin is 28-amino-acid peptide that is produced by X/A-like cells present in the stomach. Gastrin is a hormone that stimulates gastric acid secretion and mucosal cell growth. The aim: to study the interrelation between ghrelin and gastrin levels in patients with combination of chronic gastritis and type 2 diabetes mellitus. PATIENTS AND METHODS: Materials and methods: 60 Helicobacter pylori positive patients with a combination of chronic gastritis and type 2 diabetes mellitus were examined...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29719591/acidic-bile-salts-induces-mucosal-barrier-dysfunction-through-let-7a-reduction-during-gastric-carcinogenesis-after-helicobacter-pylori-eradication
#16
Yasushi Takahashi, Kaname Uno, Katsunori Iijima, Yasuhiko Abe, Tomoyuki Koike, Naoki Asano, Kiyotaka Asanuma, Tooru Shimosegawa
Gastric cancer (GC) after eradication for Helicobacter pylori ( H.pylori ) increases, but its carcinogenesis is not elucidated. It is mainly found in acid non-secretion areas (ANA), as mucosal regeneration in acid secretory areas (AA) after eradication changes the acidity and bile toxicity of gastric juice. We aimed to clarify the role of barrier dysfunction of ANA by the stimulation of pH3 bile acid cocktail (ABC) during carcinogenesis. We collected 18 patients after curative endoscopic resection for GC, identified later than 24 months after eradication, and took biopsies by Congo-red chromoendoscopy to distinguish AA and ANA (UMIN00018967)...
April 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29719459/anticancer-activity-and-potential-mechanisms-of-1c-a-ginseng-saponin-derivative-on-prostate-cancer-cells
#17
Xu De Wang, Guang Yue Su, Chen Zhao, Fan Zhi Qu, Peng Wang, Yu Qing Zhao
Background: AD-2 (20( R )-dammarane-3b, 12b, 20, 25-tetrol; 25-OH-PPD) is a ginsenoside and isolated from Panax ginseng , showing anticancer activity against extensive human cancer cell lines. In this study, effects and mechanisms of 1C ((20 R )-3b- O -(L-alanyl)-dammarane-12b, 20, 25-triol), a modified version of AD-2, were evaluated for its development as a novel anticancer drug. Methods: MTT assay was performed to evaluate cell cytotoxic activity. Cell cycle and levels of reactive oxygen species (ROS) were determined using flow cytometry analysis...
April 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29712933/effect-of-electroacupuncture-on-99m-tc-sodium-pertechnetate-uptake-and-extracellular-fluid-free-molecules-in-the-stomach-in-acupoint-st36-and-st39
#18
Rui Gao, Shan Gao, Jinteng Feng, Hongying Cui, Yanchao Cui, Junke Fu, Guangjian Zhang
Electroacupuncture (EA) is a therapeutic modality in which the electrical stimulation is integrated with concepts of acupuncture to treat diseases. This study was designed to evaluate the connection between the electro-acupuncture induced increase in Na99m TcO4 uptake in the stomach wall, and the ionic molecule levels in the extracellular fluid in the acupoints. Wistar rats were treated by 2 or 100 Hz EA at Zusanli (ST 36) and Xiajuxu (ST 39) bilaterally for 60 minutes. The accumulation of Na99m TcO4 in the gastric wall and the free ions, including Ca2+ , K+ , Na+ , and Cl- , in the acupoints were measured every 60 minutes...
April 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29710474/resveratrol-inhibits-interleukin-6-induced-invasion-of-human-gastric-cancer-cells
#19
Tingting Yang, Jianmei Zhang, Junting Zhou, Meixiao Zhu, Li Wang, Lianhe Yan
Previous studies show that migration and invasion are the primary causes of death in patients with gastric carcinoma. Increasing evidences have been shown Interleukin-6 could stimulate cancer cells invasion and be associated with cancer development. However, its role in gastric cancer has never been investigated. As an anticancer drug isolated from Chinese medicine, resveratrol was reported to inhibit cancer cells growth and induce apoptosis, but its roles in gastric cancer have not been well understood. In this study, we found that Interleukin-6 was upregulated in blood of gastric cancer patients by enzyme-linked immunosorbent assay...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29709516/cancer-associated-fibroblasts-stimulated-interleukin-11-promotes-metastasis-of-gastric-cancer-cells-mediated-by-upregulation-of-muc1
#20
Xiaoxun Wang, Xiaofang Che, Chang Liu, Yibo Fan, Ming Bai, Kezuo Hou, Xiaonan Shi, Xiaojie Zhang, Bofang Liu, Chunlei Zheng, Yunpeng Liu, Xiujuan Qu
Cancer-associated fibroblasts (CAFs) are major components of the tumor stroma and regulators of tumor progression. However, the molecular mechanism by which CAFs promote gastric cancer progression should be further explored. In our study, we found that interleukin-11 (IL-11) secretion was significantly increased when CAFs were co-cultured with gastric cancer cells. Co-culture system-derived IL-11 promoted the migration and invasion of gastric cancer cells, whereas the increase of migration and invasion was attenuated by a neutralizing antibody of IL-11 or inhibition of JAK/STAT3 and MAPK/ERK pathways with specific inhibitors...
April 27, 2018: Experimental Cell Research
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