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https://www.readbyqxmd.com/read/28105483/gastric-acid-secretion-and-gastrin-release-during-continuous-vagal-neuromonitoring-in-thyroid-surgery
#1
Liu Xiaoli, Che-Wei Wu, Hoon Yub Kim, Wen Tian, Feng-Yu Chiang, Renbin Liu, Angkoon Anuwong, Gregory W Randolph, Gianlorenzo Dionigi, Matteo Lavazza
PURPOSE: The vagus nerve (VN) has essential regulatory roles in the gastric acid secretion and gastrin release. Continuous intraoperative neuromonitoring (CIONM) via VN stimulation is a promising technique in thyroid surgery because it potentially avoids injury to the recurrent laryngeal nerve. However, no studies have investigated changes in gastric acid secretion and gastrin release during CIONM. METHOD: This prospective study of 58 thyroid surgery patients compared gastric acid and serum gastrin at five time points: (1) before skin incision, (2) after baseline calibration of CIONM probe, (3) +20 min from baseline, (4) before probe removal, and (5) after extubation...
January 19, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28101212/effect-of-oxaliplatin-combined-with-polyenephosphatidylcholine-on-the-proliferation-of-human-gastric-cancer-sgc-7901-cells
#2
Tao Jiang, Hongjun Zhang, Xiguang Liu, Hao Song, Ruyong Yao, Jianbin Li, Yuanyuan Zhao
Oxaliplatin (L-OHP) is a platinum compound that is widely used to treat certain solid tumors, including gastric tumors. L-OHP is an effective anti-cancer treatment; however, its usage increases the probability of patients developing hepatic injury with inflammation, referred to as chemotherapy-associated steatohepatitis. The present study aimed to evaluate the outcome of L-OHP treatment combined with polyenephosphatidylcholine (PPC), a major component of essential phospholipids used to treat steatohepatitis, on SGC-7901 gastric cancer cell proliferation...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28091894/mechanisms-of-action-of-surgical-interventions-on-weight-related-diseases-the-potential-role-of-bile-acids
#3
REVIEW
Mohsen Mazidi, Pedro Paulo P de Caravatto, John R Speakman, Ricardo V Cohen
Surgical interventions for weight-related diseases (SWRD) may have substantial and sustainable effect on weight reduction, also leading to a higher remission rate of type 2 diabetes (T2D) mellitus than any other medical treatment or lifestyle intervention. The resolution of T2D after Roux-en-Y gastric bypass (RYGB) typically occurs too quickly to be accounted for by weight loss alone, suggesting that these operations have a direct impact on glucose homeostasis. The mechanisms underlying these beneficial effects however remain unclear...
January 14, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28089681/steatorrhea-and-hyperoxaluria-in-severely-obese-patients-before-and-after-roux-en-y-gastric-bypass
#4
Amber M Moreland, Carol A Santa Ana, John R Asplin, Joseph A Kuhn, Ross P Holmes, Jason A Cole, Elizabeth A Odstrcil, Thomas G Van Dinter, Juan G Martinez, John S Fordtran
BACKGROUND: Hyperoxaluria after Roux-en-Y gastric bypass (RYGB) is generally attributed to fat malabsorption. If hyperoxaluria is indeed caused by fat malabsorption, magnitudes of hyperoxaluria and steatorrhea should correlate. Severely obese patients, prior to bypass, ingest excess dietary fat, which can produce hyperphagic steatorrhea. The primary objective of the study was to determine whether urine oxalate excretion correlates with elements of fat balance in severely obese patients before and after RYGB...
January 12, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28087652/differential-regulation-of-cd103-%C3%AE-e-integrin-expression-in-human-dendritic-cells-by-retinoic-acid-and-toll-like-receptor-ligands
#5
Mandi M Roe, Steve Swain, T Andrew Sebrell, Marisa A Sewell, Madison M Collins, Brian A Perrino, Phillip D Smith, Lesley E Smythies, Diane Bimczok
CD103 (αE integrin) is an important dendritic cell (DC) marker that characterizes functionally distinct DC subsets in mice and humans. However, the mechanism by which CD103 expression is regulated in human DCs and the role of CD103 for DC function are not very well understood. Here, we show that retinoic acid (RA) treatment of human monocyte-derived DCs (MoDCs) increased the ability of the DCs to synthesize RA and induced MoDC expression of CD103 and β7 at the mRNA and protein level. In contrast, RA was unable to induce the expression of CD103 in primary human DCs isolated from the gastric mucosa...
January 13, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28074309/helicobacter-pylori-induced-premature-senescence-of-extragastric-cells-may-contribute-to-chronic-skin-diseases
#6
Anna Lewinska, Maciej Wnuk
Helicobacter pylori, one of the most frequently observed bacterium in the human intestinal flora, has been widely studied since Marshall and Warren documented a link between the presence of H. pylori in the gastrointestinal tract and gastritis and gastric ulcers. Interestingly, H. pylori has also been found in several other epithelial tissues, including the eyes, ears, nose and skin that may have direct or indirect effects on host physiology and may contribute to extragastric diseases, e.g. chronic skin diseases...
January 10, 2017: Biogerontology
https://www.readbyqxmd.com/read/28066619/clinical-management-of-chronic-obstructive-pulmonary-disease-patients-with-muscle-dysfunction
#7
REVIEW
Joaquim Gea, Carme Casadevall, Sergi Pascual, Mauricio Orozco-Levi, Esther Barreiro
Muscle dysfunction is frequently observed in chronic obstructive pulmonary disease (COPD) patients, contributing to their exercise limitation and a worsening prognosis. The main factor leading to limb muscle dysfunction is deconditioning, whereas respiratory muscle dysfunction is mostly the result of pulmonary hyperinflation. However, both limb and respiratory muscles are also influenced by other negative factors, including smoking, systemic inflammation, nutritional abnormalities, exacerbations and some drugs...
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28052887/impact-of-human-milk-pasteurization-on-gastric-digestion-in-preterm-infants-a-randomized-controlled-trial
#8
Samira C de Oliveira, Amandine Bellanger, Olivia Ménard, Patrick Pladys, Yann Le Gouar, Emelyne Dirson, Florian Kroell, Didier Dupont, Amélie Deglaire, Claire Bourlieu
BACKGROUND: Holder pasteurization has been reported to modify human milk composition and structure by inactivating bile salt-stimulated lipase (BSSL) and partially denaturing some of its proteins, potentially affecting its subsequent digestion. OBJECTIVE: We sought to determine the impact of human milk pasteurization on gastric digestion (particularly for proteins and lipids) in preterm infants who were fed their mothers' own milk either raw or pasteurized. DESIGN: In a randomized controlled trial, 12 hospitalized tube-fed preterm infants were their own control group in comparing the gastric digestion of raw human milk (RHM) with pasteurized human milk (PHM)...
January 4, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28049228/enhancement-of-gastric-ulcer-healing-and-angiogenesis-by-hepatocyte-growth-factor-gene-mediated-by-attenuated-salmonella-in-rats
#9
Xiaoqin Ha, Junhua Peng, Hongbin Zhao, Zhiyun Deng, Juzi Dong, Hongyan Fan, Yong Zhao, Bing Li, Qiangsheng Feng, Zhihua Yang
The present study developed an oral hepatocyte growth factor (HGF) gene therapy strategy for gastric ulcers treatment. An attenuated Salmonella typhimurium that stably expressed high HGF (named as TPH) was constructed, and the antiulcerogenic effect of TPH was evaluated in a rat model of gastric ulcers that created by acetic acid subserosal injection. From day 5 after injection, TPH (1 × 10⁹ cfu), vehicle (TP, 1 × 10⁹ cfu), or sodium bicarbonate (model control) was administered orally every alternate day for three times...
February 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28047017/su-c-204-07-radiation-therapy-as-a-potential-treatment-for-obesity-initial-data-from-a-preclinical-investigation
#10
A Pasciak, Y Bradley, L Nodit, A Bourgeois, B Paxton, A Arepally
PURPOSE: To evaluate the feasibility of Yttrium-90 (90Y) radionuclide therapy as a potential treatment for obesity in a porcine model. As the only appetite-stimulating hormone, localized targeting of ghrelin-producing X/A cells in the fundus of the stomach using 90Y may reduce serum ghrelin levels and decrease hunger. METHODS: Under approval of the University of Tennessee IACUC, 8 young female pigs aged 12-13 weeks and weighing 21.8-28.1 Kg were included in this study...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28044198/meloxicam-medication-reduces-orthodontically-induced-dental-root-resorption-and-tooth-movement-velocity-a-combined-in-vivo-and-in-vitro-study-of-dental-periodontal-cells-and-tissue
#11
Christian Kirschneck, Matthias Meier, Kathrin Bauer, Peter Proff, Jochen Fanghänel
Non-steroidal anti-inflammatory drugs (NSAID) are used to alleviate pain sensations during orthodontic therapy but are also assumed to interfere with associated pseudo-inflammatory reactions. In particular, the effects of partially selective COX-2 inhibition over the constitutively expressed COX-1 (11:1) on periodontal cells and tissue, as induced by the NSAID meloxicam, remain unclear. We investigate possible adverse side-effects and potentially useful beneficial effects during orthodontic therapy and examine underlying cellular and tissue reactions...
January 3, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28036160/bile-acids-a-potential-role-in-the-pathogenesis-of-pharyngeal-malignancy
#12
Z Shellman, A Aldhahrani, B Verdon, M Mather, V Paleri, J Wilson, J Pearson, C Ward, J Powell
OBJECTIVE: Gastro-oesophageal reflux disease is thought to be a risk factor for head and neck malignancies. Bile acids are one of the principle components of gastric refluxate and have previously been implicated in the development of oesophageal and bowel malignancies. There is clear evidence that bile acids reflux into the laryngopharynx. Despite this, the carcinogenic properties of bile acids in this area are yet to be fully identified. We therefore investigated the potential role of bile acids in pharyngeal malignancy, through the highly conserved process of epithelial-mesenchymal transition (EMT)...
December 30, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28035532/ghrelin-and-motilin-control-systems-in-gi-physiology-and-therapeutics
#13
Gareth J Sanger, John Broad, Brid Callaghan, John B Furness
Ghrelin and motilin are released from gastrointestinal endocrine cells during hunger, to act through G protein-coupled receptors that have closely related amino acid sequences. The actions of ghrelin are more complex than motilin because ghrelin also exists outside the GI tract, it is processed to des-acyl ghrelin which has activity, ghrelin can exist in truncated forms and retain activity, the ghrelin receptor can have constitutive activity and is subject to biased agonism and finally additional ghrelin-like and des-acyl ghrelin receptors are proposed...
December 30, 2016: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/28019659/na-h-exchanger-nhe1-and-nhe2-have-opposite-effects-on-migration-velocity-in-the-rat-gastric-surface-cells
#14
Anja Paehler Vor der Nolte, Giriprakash Chodisetti, Zhenglin Yuan, Florian Busch, Brigitte Riederer, Min Luo, Yan Yu, Manoj B Menon, Andreas Schneider, Renata Stripecke, Katerina Nikolovska, Sunil Yeruva, Ursula Seidler
Following superficial injury, neighbouring gastric epithelial cells close the wound by rapid cell migration, a process called epithelial restitution. Na(+) /H(+) exchange (NHE) inhibitors interfere with restitution, but the role of the different NHE isoforms expressed in gastric pit cells has remained elusive. The role of the basolaterally expressed NHE1 (Slc9a1) and the presumably apically expressed NHE2 (Slc9a2) in epithelial restitution was investigated in the nontransformed rat gastric surface cell line RGM1...
December 26, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28017829/12-chloracetyl-ppd-a-novel-dammarane-derivative-shows-anti-cancer-activity-via-delay-the-progression-of-cell-cycle-g2-m-phase-and-reactive-oxygen-species-mediate-cell-apoptosis
#15
Xu De Wang, Yuan Yuan Sun, Chen Zhao, Fan Zhi Qu, Yu Qing Zhao
(20R)-Dammarane-3β, 12β, 20, 25-tetrol (25-OH-PPD) is a ginsenoside isolated from Panax ginseng (C. A. Meyer). This compound exhibits anti-cancer activities on many human cancer cell lines. In this study, we investigated anti-cancer mechanisms of 12β-O-(L-Chloracetyl)-dammar-20(22)-ene-3β,25-diol(12-Chloracetyl-PPD), a modified 25-OH-PPD. We found that compound 12-Chloracetyl-PPD resulted in a concentration-dependent inhibition of viability in prostate, breast, and gastric cancer cells, without affecting the viability of normal cell (human gastric epithelial cell line-GES-1, hair follicle dermal papilla cell line-HHDPC and rat myocardial cell line-H9C2)...
December 23, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28013450/post-implant-analysis-of-epidemiologic-and-eating-behavior-data-related-to-weight-loss-effectiveness-in-obese-patients-treated-with-gastric-electrical-stimulation
#16
I Alarcón Del Agua, M Socas-Macias, L Busetto, A Torres-Garcia, A Barranco-Moreno, P P Garcia de Luna, S Morales-Conde
OBJECTIVE: To determine possible preoperative predictors for obtaining clinically meaningful weight loss with gastric electrical stimulation (GES) using the "Three-Factor Eating Questionnaire" (TFEQ) as well as epidemiological data. METHODS: Ninety-seven obese participants in a prospective multicenter randomized study conducted in nine European centers were implanted laparoscopically with the abiliti® closed-loop GES system (CLGES). Five clinical variables and three preoperative TFEQ factor scores (F1-cognitive-restraint, F2-disinhibition, and F3-hunger) were analyzed in order to determine predictors of weight loss success defined as excess weight loss (EWL) > 30% and failure defined as EWL < 20% at 12 months post-surgery...
December 24, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/28013186/ponciretin-attenuates-ethanol-induced-gastric-damage-in-mice-by-inhibiting-inflammatory-responses
#17
Geum-Dan Kang, Dong-Hyun Kim
BACKGROUND: Poncirin (PO) and isosakuranetin (or ponciretin [PT]) are compounds found in fruits of the genus Citrus. They are frequently used in traditional Chinese medicine for the treatment of inflammation and asthma. Therefore, we examined their anti-gastritis effects in vitro and in vivo. METHODS: The anti-inflammatory effects of PO and PT were examined using ethanol- or LPS-stimulated KATO III cells. Gastritis was induced in ICR mice via intragastric injection of absolute ethanol...
February 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28012316/the-effect-of-trimethylamine-n-oxide-on-helicobacter-pylori-induced-changes-of-immunoinflammatory-genes-expression-in-gastric-epithelial-cells
#18
Daoyan Wu, Mei Cao, Jingshan Peng, Ningzhe Li, Sijun Yi, Liju Song, Xuege Wang, Mao Zhang, Jian Zhao
Colonization of Helicobacter pylori (H. pylori) induces immune and inflammatory response in gastric mucosa. Trimethylamine N-oxide (TMAO), from diet and metabolite through the action of gut microbiota, has been linked to inflammatory diseases. To investigate the effects of TMAO and H. pylori infection on gene expression in gastric epithelial cells, Human gene chip Affymetrix HTA 2.0 was used in this study. 1312 genes were identified as differentially expressed genes in GES-1 cells with H. pylori and TMAO co-treatment compared to the control...
February 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28012218/met4-expression-predicts-poor-prognosis-of-gastric-cancers-with-helicobacter-pylori-infection
#19
Naoko Sakamoto, Hironori Tsujimoto, Risa Takahata, Cao Brian, Zhao Ping, Nozomi Ito, Hideyuki Shimazaki, Takashi Ichikura, Kazuo Hase, George F Vande Woude, Nariyoshi Shinomiya
Role of HGF/SF-MET signaling is important in cancer progression, but its relation with Helicobacter pylori-positive gastric cancers remains to be elucidated. In total, 201 patients with primary gastric carcinoma who underwent curative or debulking resection without preoperative chemotherapy were studied. MET4 and anti-HGF/SF mAbs were used for immunohistochemical analysis. Survival of gastric cancer patients was estimated by Kaplan-Meier method and compared with log-rank. Cox proportional hazards models were fit to determine the independent association of MET-staining status with outcome...
December 23, 2016: Cancer Science
https://www.readbyqxmd.com/read/28011625/gastric-cancer-cell-proliferation-and-survival-is-enabled-by-a-cyclophilin-b-stat3-microrna-520d-5p-signaling-feedback-loop
#20
Ting Li, Hanqing Guo, Xiaodi Zhao, Jiang Jin, Lifeng Zhang, Hong Li, Yuanyuan Lu, Yongzan Nie, Kaichun Wu, Yongquan Shi, Daiming Fan
Molecular links between inflammation and cancer remain obscure despite their great pathogenic significance. The JAK2/STAT3 pathway activated by IL-6 and other pro-inflammatory cytokines has garnered attention as a pivotal link in cancer pathogenesis, but the basis for its activation in cancer cells is not understood. Here we report that an IL-6-triggered feedback loop involving STAT3-mediated suppression of miR-520d-5p and its downstream target cyclophilin B (CypB) regulates the growth and survival of gastric cancer cells...
December 23, 2016: Cancer Research
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