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https://www.readbyqxmd.com/read/29161697/age-period-cohort-modeling-of-multiple-sclerosis-incidence-rates-in-kuwait-1980-2014
#1
Saeed Akhtar, Jarrah Al-Abkal, Jasem Y Al-Hashel, Raed Alroughani
BACKGROUND: Multiple sclerosis (MS) is a complex immune-mediated disorder of the central nervous system with undefined etiology. Genetic predisposition and environmental factors play an imperative role in MS causation and its sustained increasing burden worldwide. This study examined the age, period, and cohort effects on MS incidence rates in Kuwait. METHODS: In this retrospective cohort study, data on MS cases diagnosed between January 1, 1980 and December 31, 2014 and registered in National MS Registry and reference population were obtained...
November 21, 2017: Neuroepidemiology
https://www.readbyqxmd.com/read/29161673/reduced-resting-state-thalamostriatal-functional-connectivity-is-associated-with-excessive-daytime-sleepiness-in-persons-with-and-without-depressive-disorders
#2
David T Plante, Rasmus M Birn, Erin C Walsh, Roxanne M Hoks, M Daniela Cornejo, Heather C Abercrombie
BACKGROUND: Excessive daytime sleepiness (EDS) is a common and significant problem encountered in affective illness, however, the biological underpinnings of EDS in persons with psychiatric disorders are not clear. This study evaluated the associations between thalamic connectivity with cortical and subcortical brain regions with EDS in persons with and without depressive disorders (DD). METHODS: Resting-state functional connectivity magnetic resonance imaging scans from 67 unmedicated young to middle-aged women with current DD (n = 30), remitted DD (n = 13), and healthy controls (n = 24) were utilized to examine the associations between thalamic connectivity with cortical/subcortical structures and EDS...
November 14, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29161422/prevalence-and-genetic-variability-of-human-polyomaviruses-6-and-7-in-healthy-skin-among-asymptomatic-individuals
#3
Yumiko Hashida, Tomonori Higuchi, Shigenobu Matsuzaki, Kimiko Nakajima, Shigetoshi Sano, Masanori Daibata
Background: Despite the pathogenetic potential of human polyomavirus 6 (HPyV6) and human polyomavirus 7 (HPyV7), they have been found in the normal skin of healthy individuals. However, little is known about the prevalence, infection levels, and geographical variations of these polyomaviruses in the skin. Methods: Using skin swabs from 470 participants aged 2-98 years, we estimated the prevalence of copy numbers of HPyV6 and HPyV7 with respect to age and ethnicity...
November 17, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29161197/acceptance-and-psychological-change-at-the-higher-levels-of-care-a-naturalistic-outcome-study
#4
Keegan Walden, Jamie Manwaring, Dan V Blalock, Emmett Bishop, Alan Duffy, Craig Johnson
This naturalistic outcome study reports on psychological change among a large (N = 617), transdiagnostic sample of eating disordered adults treated at higher levels of care at a private facility. Patients were assessed at admission and discharge for eating disorder psychopathology, depression, personality, and acceptance. Effect sizes ranged from d = .29 to d = 1.29, and the majority of participants (58.2%) were treatment responders, with BN patients showing a higher response rate than AN-R patients. Increased acceptance over the course of treatment was strongly associated with decreased eating disorder risk and may be an important factor in recovery...
November 21, 2017: Eating Disorders
https://www.readbyqxmd.com/read/29160112/the-human-right-to-communicate-and-our-need-to-listen-learning-from-people-with-a-history-of-childhood-communication-disorder
#5
Jane McCormack, Elise Baker, Kathryn Crowe
PURPOSE: In 2013, the Australian Government Senate formed a committee for inquiry and report into the prevalence of speech, language, and communication disorders and speech pathology services in Australia. Submissions were sought from individuals and organisations. In this paper, submissions made by individuals with a history of childhood communication disorder were examined to explore their life experiences and the impact on their lives when the right to communicate could not be enacted...
November 21, 2017: International Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/29159848/speech-deterioration-in-amyotrophic-lateral-sclerosis-als-after-manifestation-of-bulbar-symptoms
#6
Tanja Makkonen, Hanna Ruottinen, Riitta Puhto, Mika Helminen, Johanna Palmio
BACKGROUND: The symptoms and their progression in amyotrophic lateral sclerosis (ALS) are typically studied after the diagnosis has been confirmed. However, many people with ALS already have severe dysarthria and loss of adequate speech at the time of diagnosis. Speech-and-language therapy interventions should be targeted timely based on communicative need in ALS. AIMS: To investigate how long natural speech will remain functional and to identify the changes in the speech of persons with ALS...
November 21, 2017: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/29159404/variation-in-the-12-month-treatment-trajectories-of-children-and-adolescents-after-a-diagnosis-of-depression
#7
Nina R Joyce, Megan S Schuler, Scott E Hadland, Laura A Hatfield
Importance: Depression during childhood and adolescence is heterogeneous. Treatment patterns are often examined in aggregate, yet there is substantial variability across individual treatment trajectories. Understanding this variability can help identify treatment gaps among youths with depression. Objective: To characterize heterogeneity in 12-month trajectories of psychotherapy and antidepressant treatment in youths with depression. Design, Setting, and Participants: This is a longitudinal-cohort study of youths 18 years or younger with a new diagnosis of depression and at least 12 months of follow-up following diagnosis, as determined from commercial insurance claims filed from 2007 to 2014...
November 20, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/29159398/cost-effectiveness-of-publicly-funded-treatment-of-opioid-use-disorder-in-california
#8
Emanuel Krebs, Benjamin Enns, Elizabeth Evans, Darren Urada, M Douglas Anglin, Richard A Rawson, Yih-Ing Hser, Bohdan Nosyk
Background: Only 1 in 5 of the nearly 2.4 million Americans with an opioid use disorder received treatment in 2015. Fewer than half of Californians who received treatment in 2014 received opioid agonist treatment (OAT), and regulations for admission to OAT in California are more stringent than federal regulations. Objective: To determine the cost-effectiveness of OAT for all treatment recipients compared with the observed standard of care for patients presenting with opioid use disorder to California's publicly funded treatment facilities...
November 21, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29159135/the-influence-of-schizotypal-traits-on-attention-under-high-perceptual-load
#9
Hanne Stotesbury, Sebastian B Gaigg, Saim Kirhan, Corinna Haenschel
Schizophrenia Spectrum Disorders (SSD) are known to be characterised by abnormalities in attentional processes, but there are inconsistencies in the literature that remain unresolved. This article considers whether perceptual resource limitations play a role in moderating attentional abnormalities in SSD. According to perceptual load theory, perceptual resource limitations can lead to attenuated or superior performance on dual-task paradigms depending on whether participants are required to process, or attempt to ignore, secondary stimuli...
March 2018: Schizophrenia Research. Cognition
https://www.readbyqxmd.com/read/29158609/three-way-interaction-of-neuroticism-extraversion-and-conscientiousness-in-the-internalizing-disorders-evidence-of-disorder-specificity-in-a-psychiatric-sample
#10
Kristin Naragon-Gainey, Leonard J Simms
It is well-established that neuroticism, extraversion, and conscientiousness are individually associated with internalizing disorders, but research suggests that these main effects may be qualified by a three-way interaction when predicting depression. The current study was the first to examine this three-way interaction in a psychiatric sample (N=463) with a range of internalizing symptoms as the outcomes. Using two omnibus personality inventories and a diagnostic interview, the expected three-way interaction emerged most consistently for symptoms of major depression, and there was also evidence of synergistic effects for post-traumatic stress disorder and generalized anxiety disorder...
October 2017: Journal of Research in Personality
https://www.readbyqxmd.com/read/29158232/development-and-validation-of-qdiabetes-2018-risk-prediction-algorithm-to-estimate-future-risk-of-type-2-diabetes-cohort-study
#11
Julia Hippisley-Cox, Carol Coupland
Objectives To derive and validate updated QDiabetes-2018 prediction algorithms to estimate the 10 year risk of type 2 diabetes in men and women, taking account of potential new risk factors, and to compare their performance with current approaches.Design Prospective open cohort study.Setting Routinely collected data from 1457 general practices in England contributing to the QResearch database: 1094 were used to develop the scores and a separate set of 363 were used to validate the scores.Participants 11...
November 20, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29157997/smaller-amygdala-volume-and-increased-neuroticism-predict-anxiety-symptoms-in-healthy-subjects-a-volumetric-approach-using-manual-tracing
#12
Yifan Hu, Matthew Moore, Zachariah Bertels, K Luan Phan, Florin Dolcos, Sanda Dolcos
Volume reductions in the amygdala (AMY) have been found in patients with anxiety disorders, but findings are mixed in subclinical participants with high trait anxiety scores, in whom both reductions and increases in AMY volume have been identified. One potential reason for such discrepancies could be the employment of different methods to determine the AMY volume (i.e., manual tracing in psychiatric research vs. automated methods), in non-patient research. In addition to trait anxiety, smaller AMY volume has also been linked to neuroticism, a personality trait consistently linked to increased vulnerability to anxiety...
November 17, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/29157845/face-perception-in-social-anxiety-visuocortical-dynamics-reveal-propensities-for-hypervigilance-or-avoidance
#13
Lisa M McTeague, Marie-Claude Laplante, Hailey W Bulls, Joshua R Shumen, Peter J Lang, Andreas Keil
BACKGROUND: Theories of aberrant attentional processing in social anxiety, and anxiety disorders more broadly, have postulated an initial hypervigilance or facilitation to clinically relevant threats and consequent defensive avoidance. However, existing objective measurements utilized to explore this phenomenon lack the resolution to elucidate attentional dynamics, particularly covert influences. METHODS: We utilized a continuous measure of visuocortical engagement, the steady-state visual evoked potential in response to naturalistic angry, fearful, happy, and neutral facial expressions...
October 13, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29157333/a-cohort-mortality-study-among-soviet-and-russian-cosmonauts-1961-2014
#14
Igor B Ushakov, Yuri I Voronkov, Igor V Bukhtiyarov, Galina I Tikhonova, Tatyana Yu Gorchakova, Mariya S Bryleva
INTRODUCTION: Over 500 people from different countries have been to space since the first manned spaceflight in 1961. Factors of space and spaceflights might cause functional and somatic disorders, leading to increased mortality. Our research goal was to assess cause-specific risk of death among Soviet and Russian cosmonauts who had at least one spaceflight. METHODS: The epidemiological cohort study included 115 male cosmonauts. The observation period was 54 yr (January 1, 1961-December 31, 2014) and 2707 person-years of follow-up were obtained...
December 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29157207/an-ethnographic-study-of-the-effects-of-cognitive-symptoms-in-patients-with-major-depressive-disorder-the-impact-study
#15
Bjarke Ebert, Kamilla Miskowiak, Morten Kloster, Jon Johansen, Cara Eckholm, Torbjörn Wærner, Mads Holme, Louise Meldgaard Bruun
BACKGROUND: The manifestation of major depressive disorder (MDD) may include cognitive symptoms that can precede the onset of MDD and persist beyond the resolution of acute depressive episodes. However, little is known about how cognitive symptoms are experienced by MDD patients and the people around them. METHODS: In this international (Brazil, Canada, China, France, and Germany) ethnographic study, we conducted semi-structured interviews and observations of remitted as well as symptomatic MDD patients (all patients self-reported being diagnosed by an HCP and self-reported being on an antidepressant) aged 18-60 years with self-reported cognitive symptoms (N = 34)...
November 21, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/29157155/work-environment-and-occupational-risk-assessment-for-small-animal-portuguese-veterinary-activities
#16
Angela C Macedo, Vânia T Mota, João M Tavares, Osvaldo L Machado, Francisco X Malcata, Marinela P Cristo, Olga N Mayan
The professional work of small animal veterinary staff encompasses a wide diversity of demanding tasks. This has prompted a number of studies covering physical, chemical, biological, ergonomic or psychological hazards, as well as their health effects upon veterinary workers. However, such results were obtained from self-reported surveys (via paper or online). This study reports the identification of potential hazards and provides a risk assessment of 15 veterinary clinics based on data from walk-through surveys, interviews with workers, and quantification of indoor air quality parameters including concentration of volatile organic compounds (total, isoflurane and glutaraldehyde)...
November 20, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/29156546/systematic-review-of-epigenetic-effects-of-pharmacological-agents-for-bipolar-disorders
#17
REVIEW
Laura E Lockwood, Nagy A Youssef
Epigenetic effects of medications are an evolving field of medicine, and can change the landscape of drug development. The aim of this paper is to systematically review the literature of the relationship between common medications used for treatment of bipolar disorders and epigenetic modifications. MedLine/PubMed searches were performed based on pre-specified inclusion criteria from inception to November 2017. Six animal and human studies met the inclusion criteria. These studies examined the epigenetic changes in the main classes of medications that are used in bipolar disorders, namely mood stabilizers and antipsychotics...
November 18, 2017: Brain Sciences
https://www.readbyqxmd.com/read/29156427/a-longitudinal-analysis-of-the-effects-of-neuroticism-and-extraversion-on-subjective-well-being-in-patients-with-schizophrenia
#18
Floor A van Dijk, Frederike Schirmbeck, Lieuwe de Haan
One in five patients with a psychotic disorder has persistent low subjective well-being (SWB), which is associated with a poorer prognosis. In schizophrenia patients, personality traits are associated with SWB. The present study aims to evaluate whether neuroticism and extraversion influence SWB in patients with a psychotic disorder and healthy controls over the course of time. In 186 patients and 126 healthy control subjects, SWB was measured with the Subjective Well-being under Neuroleptics-20 (SWN) scale at baseline, three years and six years...
November 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29156359/emotion-regulation-deficits-in-persons-with-body-focused-repetitive-behavior-disorders
#19
Jennifer R Alexander, David C Houghton, Christopher C Bauer, Heather C Lench, Douglas W Woods
BACKGROUND: Conceptualizations of emotion dysregulation (ED) and body-focused repetitive behavior disorders (BFRBDs) imply that ED may be a central component of BFRBDs as well as a factor that distinguishes BFRBDs from non-impairing, subclinical body-focused repetitive behaviors (BFRBs). The current study empirically tested these observations. METHODS: One hundred thirty-eight undergraduates (of 1900 who completed a screening survey) completed self-report measures assessing four emotion regulation (ER) deficits hypothesized to underlie ED (alexithymia, maladaptive emotional reactivity, experiential avoidance, and response inhibition when distressed); 34 of these participants had BFRBDs, 64 had subclinical BFRBs, and 42 were unaffected by BFRBs...
November 10, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29154601/on-studying-narcissism-in-personality-inventories-rather-than-the-narcissistic-personality-inventory-reply-to-miller-and-lynam-2017
#20
Andrea Fossati, Antonella Somma, Serena Borroni, Kristian E Markon
Miller and Lynam's (2017) commentary proved to be very helpful in clarifying that ralerting-CV and rcontrast-CV coefficient values reported in our study indicated that the Narcissistic Personality Inventory (NPI) yielded a trait profile much more closely aligned with expert ratings of Diagnostic and Statistical Manual of Mental Disorders (4th edition; DSM-IV) narcissistic personality disorder (NPD) than did other measures. The commentary gives us the opportunity to make it clear that our study was designed to demonstrate the clinical usefulness of Personality Inventory for DSM-5 (PID-5) domain and trait scales in profiling pathological narcissism...
November 2017: Psychological Assessment
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