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https://www.readbyqxmd.com/read/29753350/societal-preferences-for-funding-orphan-drugs-in-the-united-kingdom-an-application-of-person-trade-off-and-discrete-choice-experiment-methods
#1
Siobhan M Bourke, Catrin O Plumpton, Dyfrig A Hughes
BACKGROUND: It is unclear whether UK National Health Service (NHS) policies for orphan drugs, which permit funding of non-cost-effective treatments, reflect societal preferences. METHODS: We conducted person trade-off (PTO) and discrete choice experiment (DCE) among 3950 adults selected to be representative of the UK general population. Experimental design was informed by surveys of patients affected by rare diseases, their caregivers, health care staff, and policymakers...
May 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29728139/bottlenecks-concerns-and-needs-in-malaria-operational-research-the-perspectives-of-key-stakeholders-in-nigeria
#2
Pamela Onyiah, Al-Mukhtar Y Adamu, Rotimi F Afolabi, Olufemi Ajumobi, Maduka D Ughasoro, Oluwaseun Odeyinka, Patrick Nguku, IkeOluwapo O Ajayi
OBJECTIVE: We conducted a study to determine stakeholders' perspective of the bottlenecks, concerns and needs to malaria operational research (MOR) agenda setting in Nigeria. RESULTS: Eighty-five (37.9%) stakeholders identified lack of positive behavioural change as the major bottleneck to MOR across the malaria thematic areas comprising of malaria prevention 58.8% (50), case management 34.8% (39), advocacy communication and social mobilisation 4.7% (4) while procurement and supply chain management (PSM) and programme management experts had the least response of 1...
May 4, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29727316/gun-violence-two-medical-students-hometown-connection-to-this-public-health-crisis
#3
Nicholas O Kuhl, Monica P Lieberman
The school shooting in Parkland, Florida in February 2018 left 17 people dead and countless other children and teachers with physical and psychological trauma that will require decades of healing. As Marjory Stoneman Douglas High School alumni and current medical students, the authors of this Invited Commentary contend that they are in a unique position to advocate on behalf of their neighbors, classmates, and future patients. Since the authors began medical school in 2015, there have been 19 mass shootings in the United States resulting in 253 deaths...
May 2, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29695231/malaria-related-ideational-factors-and-other-correlates-associated-with-intermittent-preventive-treatment-among-pregnant-women-in-madagascar
#4
Grace N Awantang, Stella O Babalola, Hannah Koenker, Kathleen A Fox, Michael Toso, Nan Lewicky
BACKGROUND: The Malagasy Ministry of Health aimed to achieve 80% coverage of intermittent preventive treatment of malaria among pregnant women (IPTp) in targeted districts by 2015. However, IPTp coverage rates of have remained fairly static over the past few years. METHODS: During a cross-sectional household survey, mothers of children under the age of 2 years were asked about their most recent pregnancy. The primary outcome of interest was a mother receiving two or more doses of sulfadoxine-pyrimethamine (SP) (IPTp2) during their last pregnancy, at least one of which was obtained from a health provider...
April 25, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29689323/appropriate-use-criteria-in-dermatopathology-initial-recommendations-from-the-american-society-of-dermatopathology
#5
Claudia I Vidal, Eric A Armbrect, Aleodor A Andea, Angela K Bohlke, Nneka I Comfere, Sarah R Hughes, Jinah Kim, Jessica A Kozel, Jason B Lee, Konstantinos Linos, Brandon R Litzner, Tricia A Missall, Roberto A Novoa, Uma Sundram, Brian L Swick, M Yadira Hurley, Murad Alam, Zsolt Argenyi, Lyn M Duncan, Dirk M Elston, Patrick O Emanuel, Tammie Ferringer, Maxwell A Fung, Gregory A Hosler, Alexander J Lazar, Lori Lowe, Jose A Plaza, Victor G Prieto, June K Robinson, Andras Schaffer, Antonio Subtil, Wei-Lien Wang
BACKGROUND: Appropriate use criteria (AUC) provide physicians guidance in test selection, can affect health care delivery, reimbursement policy, and physician decision-making. OBJECTIVES: The American Society of Dermatopathology (ASDP), with input from the American Academy of Dermatology (AAD) and the College of American Pathologists (CAP), sought to develop AUC in dermatopathology. METHODS: The RAND/UCLA appropriateness methodology, which combines evidence-based medicine, clinical experience and expert judgment, was used to develop AUC in dermatopathology...
April 21, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29678866/gaps-in-guidelines-for-the-management-of-diabetes-in-low-and-middle-income-versus-high-income-countries-a-systematic-review
#6
REVIEW
Mayowa O Owolabi, Joseph O Yaria, Meena Daivadanam, Akintomiwa I Makanjuola, Gary Parker, Brian Oldenburg, Rajesh Vedanthan, Shane Norris, Ayodele R Oguntoye, Morenike A Osundina, Omarys Herasme, Sulaiman Lakoh, Luqman O Ogunjimi, Sarah E Abraham, Paul Olowoyo, Carolyn Jenkins, Wuwei Feng, Hernán Bayona, Sailesh Mohan, Rohina Joshi, Ruth Webster, Andre P Kengne, Antigona Trofor, Lucia Maria Lotrean, Devarsetty Praveen, Jessica H Zafra-Tanaka, Maria Lazo-Porras, Kirsten Bobrow, Michaela A Riddell, Konstantinos Makrilakis, Yannis Manios, Bruce Ovbiagele
OBJECTIVE: The extent to which diabetes (DM) practice guidelines, often based on evidence from high-income countries (HIC), can be implemented to improve outcomes in low- and middle-income countries (LMIC) is a critical challenge. We carried out a systematic review to compare type 2 DM guidelines in individual LMIC versus HIC over the past decade to identify aspects that could be improved to facilitate implementation. RESEARCH DESIGN AND METHODS: Eligible guidelines were sought from online databases and websites of diabetes associations and ministries of health...
May 2018: Diabetes Care
https://www.readbyqxmd.com/read/29643165/reoperation-after-breast-conserving-surgery-for-cancer-in-australia-statewide-cohort-study-of-linked-hospital-data
#7
Marina T van Leeuwen, Michael O Falster, Claire M Vajdic, Philip J Crowe, Sanja Lujic, Elizabeth Klaes, Louisa Jorm, Art Sedrakyan
OBJECTIVES: To investigate between-hospital variation in the probability of reoperation within 90 days of initial breast-conserving surgery (BCS), and the contribution of health system-level and other factors. DESIGN: Population-based, retrospective cohort study. SETTING: New South Wales (NSW), Australia. PARTICIPANTS: Linked administrative hospitalisation data were used to define a cohort of adult women undergoing initial BCS for breast cancer in NSW between 1 July 2002 and 31 December 2013...
April 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29580207/the-effect-of-kenya-s-free-maternal-health-care-policy-on-the-utilization-of-health-facility-delivery-services-and-maternal-and-neonatal-mortality-in-public-health-facilities
#8
C M Gitobu, P B Gichangi, W O Mwanda
BACKGROUND: Kenya abolished delivery fees in all public health facilities through a presidential directive effective on June 1, 2013 with an aim of promoting health facility delivery service utilization and reducing pregnancy-related mortality in the country. This paper aims to provide a brief overview of this policy's effect on health facility delivery service utilization and maternal mortality ratio and neonatal mortality rate in Kenyan public health facilities. METHODS: A time series analysis was conducted on health facility delivery services utilization, maternal and neonatal mortality 2 years before and after the policy intervention in 77 health facilities across 14 counties in Kenya...
March 27, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29566273/appropriate-use-criteria-in-dermatopathology-initial-recommendations-from-the-american-society-of-dermatopathology
#9
Claudia I Vidal, Eric A Armbrect, Aleodor A Andea, Angela K Bohlke, Nneka I Comfere, Sarah R Hughes, Jinah Kim, Jessica A Kozel, Jason B Lee, Konstantinos Linos, Brandon R Litzner, Tricia A Missall, Roberto A Novoa, Uma Sundram, Brian L Swick, M Yadira Hurley, Murad Alam, Zsolt Argenyi, Lyn M Duncan, Dirk M Elston, Patrick O Emanuel, Tammie Ferringer, Maxwell A Fung, Gregory A Hosler, Alexander J Lazar, Lori Lowe, Jose A Plaza, Victor G Prieto, June K Robinson, Andras Schaffer, Antonio Subtil, Wei-Lien Wang
BACKGROUND: Appropriate use criteria (AUC) provide physicians guidance in test selection, can affect health care delivery, reimbursement policy, and physician decision-making. OBJECTIVES: The American Society of Dermatopathology (ASDP), with input from the American Academy of Dermatology (AAD) and the College of American Pathologists (CAP), sought to develop AUC in dermatopathology. METHODS: The RAND/UCLA appropriateness methodology, which combines evidence-based medicine, clinical experience and expert judgment, was used to develop AUC in dermatopathology...
March 22, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29564250/time-for-the-two-spirits-shaping-the-inclusive-policy-environment-for-hispanics-and-transgenders-through-global-health-diplomacy
#10
Vijay Kumar Chattu, Mario O Laplume, Soosanna Kumary
Minority populations in the world are permanently challenged with unequal living and working conditions in their daily lives that compromise their access to needed clinical and preventive services. When we discuss the health-care conditions for minorities, we must address the social determinants of access that are ultimately determined by the policies and politics of the governments. Renowned experts of quality in healthcare have been critical of the current design and implementation of randomized clinical trials, the gold standard of clinical research because they believe that they often, but not always, presume a linear, mechanistic system when in fact improvement in health care takes place within complex adaptive systems that evolve...
October 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29563908/occurrence-of-bla-ndm-variants-among-enterobacteriaceae-from-a-neonatal-intensive-care-unit-in-a-northern-india-hospital
#11
Nayeem Ahmad, Shamsi Khalid, Syed M Ali, Asad U Khan
Carbapenem-resistance among enterobacteriaceae has become a global health concern. The objective of this study was to understand NDM producing enterobacteriaceae and their genetic basis of resistance, spreading in neonatal intensive care unit. Carbapenem resistant NDM producing enterobacteriaceae isolates were recovered from rectal swab and blood sample of infants admitted in NICU. These were determined by using Carba-NP test. All isolates were identified using BD PhoenixTM-100 and MICs were determined by broth microdilution method...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29562884/rationale-and-design-of-a-statewide-cohort-to-examine-efficient-resource-utilization-for-patients-with-intracerebral-hemorrhage-enrich
#12
Farhaan S Vahidy, Ellie G Meyer, Arvind B Bambhroliya, Jennifer R Meeks, Charles E Begley, Tzu-Ching Wu, Jon E Tyson, Charles C Miller, Ritvij Bowry, Wamda O Ahmed, Gretchel A Gealogo, Louise D McCullough, Steven Warach, Sean I Savitz
BACKGROUND: Intracerebral hemorrhage is a devastating disease with no specific treatment modalities. A significant proportion of patients with intracerebral hemorrhage are transferred to large stroke treatment centers, such as Comprehensive Stroke Centers, because of perceived need for higher level of care. However, evidence of improvement in patient-centered outcomes for these patients treated at larger stroke treatment centers as compared to community hospitals is lacking. METHODS / DESIGN: "Efficient Resource Utilization for Patients with Intracerebral Hemorrhage (EnRICH)" is a prospective, multisite, state-wide, cohort study designed to assess the impact of level of care on long-term patient-centered outcomes for patients with primary / non-traumatic intracerebral hemorrhage...
March 21, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29529918/establishing-the-value-of-diagnostic-and-prognostic-tests-in-health-technology-assessment
#13
Marta O Soares, Simon Walker, Stephen J Palmer, Mark J Sculpher
In recent years, Health Technology Assessment (HTA) processes specific to diagnostics and prognostic tests have been created in response to the increased pressure on health systems to decide not only which tests should be used in practice but also the best way to proceed, clinically, from the information they provide. These technologies differ in the way value is accrued to the population of users, depending critically on the value of downstream health care choices. This paper defines an analytical framework for establishing the value of diagnostic and prognostic tests for HTA in a way that is consistent with methods used for the evaluation of other health care technologies...
March 1, 2018: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/29494321/clinical-practice-guideline-hoarseness-dysphonia-update
#14
Robert J Stachler, David O Francis, Seth R Schwartz, Cecelia C Damask, German P Digoy, Helene J Krouse, Scott J McCoy, Daniel R Ouellette, Rita R Patel, Charles Charlie W Reavis, Libby J Smith, Marshall Smith, Steven W Strode, Peak Woo, Lorraine C Nnacheta
Objective This guideline provides evidence-based recommendations on treating patients who present with dysphonia, which is characterized by altered vocal quality, pitch, loudness, or vocal effort that impairs communication and/or quality of life. Dysphonia affects nearly one-third of the population at some point in its life. This guideline applies to all age groups evaluated in a setting where dysphonia would be identified or managed. It is intended for all clinicians who are likely to diagnose and treat patients with dysphonia...
March 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29494316/clinical-practice-guideline-hoarseness-dysphonia-update-executive-summary
#15
Robert J Stachler, David O Francis, Seth R Schwartz, Cecelia C Damask, German P Digoy, Helene J Krouse, Scott J McCoy, Daniel R Ouellette, Rita R Patel, Charles Charlie W Reavis, Libby J Smith, Marshall Smith, Steven W Strode, Peak Woo, Lorraine C Nnacheta
Objective This guideline provides evidence-based recommendations on treating patients presenting with dysphonia, which is characterized by altered vocal quality, pitch, loudness, or vocal effort that impairs communication and/or quality of life. Dysphonia affects nearly one-third of the population at some point in its life. This guideline applies to all age groups evaluated in a setting where dysphonia would be identified or managed. It is intended for all clinicians who are likely to diagnose and treat patients with dysphonia...
March 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29493897/feasibility-of-integrating-calcium-and-iron-folate-supplementation-to-prevent-preeclampsia-and-anemia-in-pregnancy-in-primary-healthcare-facilities-in-kenya
#16
Moshood O Omotayo, Katherine L Dickin, David L Pelletier, Stephanie L Martin, Jacqueline K Kung'u, Rebecca J Stoltzfus
Calcium (Ca) supplementation to prevent preeclampsia can save maternal and newborn lives, but there are no program models for integration into existing antenatal care platforms. We used a program impact pathway model to guide the design of integrated Ca and iron-folate (IFA) supplementation in Kenya. We provided healthcare providers with job aids (posters and counseling cards), trained them on counseling techniques and supplementation guidelines, and developed behavior change materials for pregnant women (pill-taking calendars)...
February 2018: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/29444116/field-evaluation-of-the-safety-acceptability-and-feasibility-of-early-infant-male-circumcision-using-the-accucirc-device
#17
Robert C Bailey, Irene Nyaboke, Mary Ellen Mackesy-Amiti, Erick Okello, Valentine Pengo, Betha Ochomo, Mary Emmaculate Auma, Simon Were, Stella Ojuok, Evelyne Adoyo, Mildred Adhiambo, Marisa R Young, Rebeca M Plank, Fredrick O Otieno
BACKGROUND: As countries scale up adult voluntary medical male circumcision (VMMC) for HIV prevention, they are looking ahead to long term sustainable strategies, including introduction of early infant male circumcision (EIMC). Although a number of devices for EIMC are prequalified by the World Health Organization, evaluation of additional devices can provide policy-makers and clinicians the information required to make informed decisions. We undertook a field evaluation of the safety and acceptability of the AccuCirc device in Kisumu County, Kenya...
2018: PloS One
https://www.readbyqxmd.com/read/29427617/single-versus-multicenter-surgeons-risk-adjusted-coronary-artery-bypass-graft-procedural-outcomes
#18
A Laurie W Shroyer, William E Gioia, Muath Bishawi, Amelia S Wallace, Brian C Gulack, Ying Xian, Sean M O'Brien, Vinod H Thourani, Thomas V Bilfinger
BACKGROUND: Since 2010, 460+ hospital mergers have occurred in the United States, rerouting historical coronary artery bypass graft (CABG) referral patterns. The goals of this study were: (1) to compare risk-adjusted CABG outcomes between single-center versus multicenter surgeons; and (2) for multicenter surgeons, to evaluate the risk-adjusted outcomes between their home (primary) versus satellite (secondary) hospitals. METHODS: Using The Society of Thoracic Surgeons Adult Cardiac Surgery Database, nonemergent, first-time CABG procedures (n = 543,403) performed in the US between 2011 and 2014 were extracted across 1,120 centers and for 2,676 surgeons...
May 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29406472/novel-approach-to-emergency-departments-pediatric-readiness-across-a-health-system
#19
Isabel A Barata, Joriane M Stadnyck, Meredith Akerman, Kate OʼNeill, Jill Castaneda, Anupama Subramony, Paula Fessler, Charles Schleien, John DʼAngelo
STUDY OBJECTIVE: A gap analysis of emergency departments' (EDs') pediatric readiness across a health system was performed after the appointment of a service line health system pediatric emergency medicine (PEM) quality director. METHODS: A 55-question survey was completed by each eligible ED to generate a weighted pediatric readiness score (WPRS). The survey included questions regarding volume, ED configuration, presence of a pediatric emergency care coordinator (PECC), quality initiatives, policies and procedures, and equipment...
February 5, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29399715/introductory-overview-of-the-natural-experiments-for-translation-in-diabetes-2-0-next-d2-network-examining-the-impact-of-us-health-policies-and-practices-to-prevent-diabetes-and-its-complications
#20
REVIEW
O Kenrik Duru, Carol M Mangione, Hector P Rodriguez, Dennis Ross-Degnan, J Frank Wharam, Bernard Black, Abel Kho, Nathalie Huguet, Heather Angier, Victoria Mayer, David Siscovick, Jennifer L Kraschnewski, Lizheng Shi, Elizabeth Nauman, Edward W Gregg, Mohammed K Ali, Pamela Thornton, Steven Clauser
PURPOSE OF REVIEW: Diabetes incidence is rising among vulnerable population subgroups including minorities and individuals with limited education. Many diabetes-related programs and public policies are unevaluated while others are analyzed with research designs highly susceptible to bias which can result in flawed conclusions. The Natural Experiments for Translation in Diabetes 2.0 (NEXT-D2) Network includes eight research centers and three funding agencies using rigorous methods to evaluate natural experiments in health policy and program delivery...
February 5, 2018: Current Diabetes Reports
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