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Víctor M Lizarzaburu Rodríguez, César A Miñano García, Jeanne Caballero Egusquiza, Carlos Vásquez Castillo, Edwin Castro Hurtado
Lymphomas are solid tumors of the lymphatic system and these are divided into Hodgkin's and non-Hodgkin lymphoma. Non-Hodgkin tumors may originate from non-nodal tissues such as the gastrointestinal tract and they are considered primary when extranodal involvement is equal to or greater than 75% according to the nodal involvement. Extranodal gastrointestinal lymphomas represent 1% to 4% of tumors of the digestive tract, and 10 to 15% of all non-Hodgkin lymphomas. The stomach is the most common extranodal lymphomas site...
July 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
Enrico Derenzini, Claudio Agostinelli, Enrica Imbrogno, Ilaria Iacobucci, Beatrice Casadei, Elisa Brighenti, Simona Righi, Fabio Fuligni, Andrea Ghelli Luserna Di Rorà, Anna Ferrari, Giovanni Martinelli, Stefano Pileri, Pier Luigi Zinzani
The recent finding that MYC-driven cancers are sensitive to inhibition of the DNA damage response (DDR) pathway, prompted us to investigate the role of DDR pathway as therapeutic target in diffuse large B-cell lymphoma (DLBCL), which frequently overexpresses the MYC oncogene. In a preliminary immunohistochemical study conducted on 99 consecutive DLBCL patients, we found that about half of DLBCLs showed constitutive expression of the phosphorylated forms of checkpoint kinases (CHK) and CDC25c, markers of DDR activation, and of phosphorylated histone H2AX (γH2AX), marker of DNA damage and genomic instability...
March 30, 2015: Oncotarget
Eun-A Eum, Hawk Kim, Young-Min Kim, Soon Joo Woo, Joon Hyun Cho, Young Joo Min, Jae-Hoo Park
Anorectum is a rare location for malignant lymphoma. Involvement of is rare even for the lynphoma associated with acquired immune deficiency syndrome (AIDS), and AIDS has a relatively increased frequency of anorectal lymphoma. Most lymphomas in AIDS patients are of a B-cell origin, and T-cell lymphoma of the gastrointestinal tract is extremely rare. We report here on a case of anorectal and gastric peripheral T-cell lymphoma, unspecified (PTCLu) in a non-AIDS patient. A previously healthy 29-year-old man presented with hematochezia and tenesmus that he had suffered with for the previous 2 months...
December 2006: Korean Journal of Internal Medicine
M Iñarrairaegui, I Elizalde, A Martínez Echeverría, J M Zozaya, R Beloqui, J M Martínez Peñuela
Following acute hepatitis C virus infection (HCV), a significant percentage of patients do not clear the virus and develop a chronic hepatitis C. The symptoms, when they exist, are usually unspecific. Besides, approximately one third of the patients present extrahepatic manifestations of the infection, basically due to the lymphotropism of HCV. Outstanding amongst these, due to their clear association with HCV, are mixed cryoglobulinaemia and the production of autoantibodies (autoAb). Other diseases such as non-Hodgkin lynphoma (NHL) or autoimmune thyroiditis do not have a clearly established association...
2004: Anales del Sistema Sanitario de Navarra
You-Gang Ma, Xiao-Song Li, Han Chen, Meng-Cao Wu
OBJECTIVE: To explore the way to lower the morbidity and mortality of patients after pancreaticoduodenectomy. METHODS: Between March 1998 and March 2001, 26 patients with periampullary tumors received pancreaticoduodenectomy (PD) with Roux-Y anastomosis to reconstruct the digestive tract. Of these patients, 6 had ductal cell carcinoma at the head of the pancreas, 8 distal common bile duct carcinoma, 5 ampullar adenocarcinoma of the Vater, 6 duodenal adenocarcinoma, and 1 duodenal malignant lynphoma...
November 2002: Hepatobiliary & Pancreatic Diseases International: HBPD INT
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