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https://www.readbyqxmd.com/read/29141626/health-related-quality-of-life-of-hiv-aids-patients-on-highly-active-anti-retroviral-therapy-at-a-university-referral-hospital-in-ethiopia
#1
Abdrrahman Shemsu Surur, Fitsum Sebsibe Teni, Wondwessen Wale, Yihenew Ayalew, Betel Tesfaye
BACKGROUND: Highly active antiretroviral therapy improves the longevity of patients living with HIV/AIDS. We conducted the study in order to assess health related quality of life of HIV/AIDS patients and the association of socio-demographic and disease related variables with health related quality of life. METHODS: Health facility based cross-sectional study among 400 HIV/AIDS patients taking highly active anti-retroviral therapy from Gondar University referral hospital was conducted...
November 15, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29140874/hiv-and-age-do-not-synergistically-affect-age-related-t-cell-markers
#2
Shelli Farhadian, Emilie Jalbert, Yanhong Deng, Matthew Bidwell Goetz, Lesley S Park, Amy Justice, Robert Dubrow, Brinda Emu
INTRODUCTION: Despite major progress in controlling HIV disease through anti-retroviral therapy (ART), changes in immune phenotype and function persist in individuals with chronic HIV, raising questions about accelerated aging of the immune system. METHODS: We conducted a cross sectional study (2005-2007) of HIV-infected (n=111) and uninfected (n=114) males from the Veterans Aging Cohort Study. All HIV-infected subjects were on ART with VL<400 copies/mL for at least three years...
November 13, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29135650/pathways-from-hiv-related-stigma-to-antiretroviral-therapy-measures-in-the-hiv-care-cascade-for-women-living-with-hiv-in-canada
#3
Carmen H Logie, Ashley Lacombe-Duncan, Ying Wang, Angela Kaida, Tracey Conway, Kath Webster, Alexandra de Pokomandy, Mona R Loutfy
BACKGROUND: Associations between HIV-related stigma and reduced anti-retroviral (ART) adherence are widely established, yet the mechanisms accounting for this relationship are underexplored. There has been less attention to HIV-related stigma and its associations with ART initiation and current ART use. We examined pathways from HIV-related stigma to ART initiation, current ART use, and ART adherence among women living with HIV in Canada. METHODS: We utilized baseline survey data from a national cohort of women living with HIV in Canada (n=1425)...
November 8, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29127578/comparative-outcomes-of-bariatric-surgery-in-patients-with-and-without-human-immunodeficiency-virus
#4
Gautam Sharma, Andrew T Strong, Mena Boules, Chao Tu, Samuel Szomstein, Raul Rosenthal, John Rodriguez, Alan J Taege, Matthew Kroh
BACKGROUND: Paradoxically, advances in anti-retroviral therapy that has increased survival for patients with human immunodeficiency virus (HIV) have resulted in greater numbers of HIV+ patients developing other chronic diseases, including obesity. Little comparative literature exists detailing perioperative or metabolic outcomes of bariatric surgery in the HIV+ population compared to HIV negative (HIV-) controls. METHODS: This is a retrospective case-control study with both HIV+ (case) and HIV- control patients...
November 10, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29118747/emerging-targets-for-developing-t-cell-mediated-vaccines-for-human-immunodeficiency-virus-hiv-1
#5
REVIEW
Danushka K Wijesundara, Charani Ranasinghe, Branka Grubor-Bauk, Eric J Gowans
Human immunodeficiency virus (HIV)-1 has infected >75 million individuals globally, and, according to the UN, is responsible for ~2.1 million new infections and 1.1 million deaths each year. Currently, there are ~37 million individuals with HIV infection and the epidemic has already resulted in 35 million deaths. Despite the advances of anti-retroviral therapy (ART), a cost-effective vaccine remains the best long-term solution to end the HIV-1 epidemic especially given that the vast majority of infected individuals live in poor socio-economic regions of the world such as Sub-Saharan Africa which limits their accessibility to ART...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29048546/housing-psychosocial-and-adherence-counseling-among-hiv-persons-in-ghana
#6
Eric Y Tenkorang, Adobea Y Owusu, Amos K Laar, Eric H Yeboah
As part of providing comprehensive HIV/AIDS services, the Ghana National AIDS Control Programme (NACP) and Ministry of Health recommend that Persons Living with HIV/AIDS (PLWHAs) receive psychosocial support and follow-up visits that ensure medical and drug adherence assistance. The successful implementation of these support services requires patients to have stable and quality housing, yet studies that examine associations between housing, psychosocial support, and adherence counseling among PLWHAs in Ghana and sub-Saharan Africa are limited...
October 18, 2017: Health Promotion International
https://www.readbyqxmd.com/read/29030487/macrophage-specific-expression-of-il-37-in-hyperlipidemic-mice-attenuates-atherosclerosis
#7
Sara McCurdy, Yvonne Baumer, Emma Toulmin, Bog-Hieu Lee, William A Boisvert
Atherosclerosis, the progressive buildup of plaque within arterial blood vessels, can lead to fatal downstream events, such as heart attack or stroke. A key event contributing to the development of atherosclerosis is the infiltration of monocytes and its associated inflammation, as well as the formation of lipid-laden macrophage foam cells within the vessel wall. IL-37 is recognized as an important anti-inflammatory cytokine expressed especially by immune cells. This study was undertaken to elucidate the role of macrophage-expressed IL-37 in reducing the production and effects of proinflammatory cytokines, preventing foam cell formation, and reducing the development of atherosclerosis...
November 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29026396/willingness-by-people-living-with-hiv-aids-to-utilize-hiv-services-provided-by-village-health-team-workers-in-kalungu-district-central-uganda
#8
Mutaawe Lubogo, Ronald Anguzu, Humphrey Wanzira, Irene Namugwanya, Oliver Namuddu, Denis Ssali, Sylivia Nanyonga, Josephine Ssentongo, Janet Seeley
BACKGROUND: Less than one quarter of people in need have access to HIV services in Uganda. This study assessed willingness of people living with HIV/AIDS (PLWHAs) to utilize HIV services provided by Village Health Teams (VHTs) in Kalungu district, central Uganda. METHODS: A cross-sectional study conducted in two health facilities providing anti-retroviral therapy enrolled 312 PLWHAs. Pre-tested semi-structured questionnaires were administered to participants at household level...
March 2017: African Health Sciences
https://www.readbyqxmd.com/read/29022646/low-skeletal-mass-is-an-important-predictor-of-osteoporosis-in-hiv-infected-men-in-india
#9
Deep Dutta, Meha Sharma, Rahul Bansal, Neera Sharma, Umesh Chandra Garga, Atul Anand, Kumar Gaurav
INTRODUCTION: This study evaluated prevalence and predictors of osteoporosis and sarcopenia in men with HIV. MATERIAL AND METHODS: 220 men with HIV were screened, of which 115 men, 30-50 years-age, having at least 1-year follow-up, underwent hormonal and DEXA analysis. 40 controls were also evaluated. RESULTS: Males with HIV had significantly lower BMD and Z-scores at all sites. Osteoporosis was diagnosed in 64.35%; commonest site being radius total (49...
October 12, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/29021399/modelling-of-anti-latency-treatment-in-hiv-what-is-the-optimal-duration-of-anti-retroviral-free-hiv-remission
#10
Deborah Cromer, Mykola Pinkevych, Thomas A Rasmussen, Sharon R Lewin, Stephen J Kent, Miles P Davenport
A number of treatment strategies are currently being developed to promote anti-retroviral free HIV cure or remission. While complete elimination of the HIV reservoir would prevent recurrence of infection, it is not clear how different remission lengths would affect viral rebound and transmission. In this work we use a stochastic model to show that a treatment that achieves a one-year average time to viral remission will still lead to nearly a quarter of subjects experiencing viral rebound within the first three months...
October 11, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29017426/investigations-on-the-influence-of-zidovudine-in-the-pharmacokinetics-of-isoniazid-and-its-hepatotoxic-metabolites-in-rats
#11
Raghu Ramanathan, Karthikeyan Sivanesan
The HIV-infected patients are co-infected with many bacterial infections in which tuberculosis is most common found worldwide. These patients are often administered with combined therapy of anti-retroviral and anti-tubercular drugs which leads to several complications including hepatotoxicity or adverse drug interactions. The drug-drug interactions between the anti-retroviral and anti-tubercular drugs are not clearly defined and hence, this study was conducted to evaluate the pharmacokinetic drug-drug interactions of Zidovudine (AZT) with Isoniazid (INH) and its hepatotoxic metabolites...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28986714/comparison-of-antiretroviral-drug-resistance-among-treatment-naive-and-treated-hiv-infected-individuals-in-shiraz-iran
#12
Mohammad Ali Davarpanah, Nasrin Motazedian, Hassan Joulaei, Mohammad Reza Aghasadeghi, Hossein Faramarzi, Ehsan Aghah
The use of anti-retroviral therapy has been effective in controlling the spread of HIV-1, and has prolonged life expectancy, but this success can be affected by the emergence of drug resistance. The main goal of this study was to investigate drug resistance in the reverse transcriptase (RT), and protease (PR) genes among HIV-1 infected individuals. We systematically selected 59 HIV-1 infected individuals from Shiraz Voluntary Counseling and Testing Center (29 treatment- naïve and 30 treated). In this study intravenous drug users older than 18 were included in this study...
October 6, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28985403/anthropometric-parameters-of-hiv-infected-and-hiv-uninfected-mothers-and-their-premature-infants
#13
Carike Fouché, Evette van Niekerk, Lisanne Monica du Plessis
This study aimed to assess the maternal anthropometric parameters of human immunodeficiency virus (HIV)-infected and HIV-uninfected mothers as well as to assess the neonatal anthropometric parameters of premature infants in relation to maternal anthropometric parameters (weight, height and mid-upper-arm circumference), HIV status and anti-retroviral therapy (ART) regimen. Study participants included HIV-infected and HIV-uninfected mothers who gave birth to premature infants. All HIV-infected mothers received ART...
August 3, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/28982311/-wtf-is-prep-attitudes-towards-pre-exposure-prophylaxis-among-men-who-have-sex-with-men-and-transgender-women-in-new-york-city
#14
Matthew Thomann, Ashley Grosso, Richard Zapata, Mary Ann Chiasson
In the USA, gay and other men who have sex with men and transgender women are disproportionately affected by HIV. Uptake of pre-exposure prophylaxis (PrEP), anti-retroviral therapy to prevent HIV-negative individuals from seroconverting if exposed to HIV, by members of this population remains low, particularly among African-Americans. We conducted two focus groups to assess responses to an online social media campaign focusing on PrEP use in New York City. We designed, produced and disseminated the campaign to address knowledge of PrEP; its physical and psychological side effects; and psychosocial barriers related to PrEP adherence and sex shaming...
October 6, 2017: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/28981664/the-gendered-micropolitics-of-hiding-and-disclosing-assessing-the-spread-and-stagnation-of-information-on-two-new-emtct-policies-in-a-malawian-village
#15
Janneke Verheijen
Analysing why certain information spreads-or not-can be highly relevant for understanding an intervention's potential impact. Two recently implemented policy changes related to EMTCT (elimination of mother-to-child transmission of HIV) in the Balaka district of Malawi give ample opportunity to assess how new information trickles through a targeted rural community. One of the policies entails the lifetime provision of ART (anti-retroviral therapy) to all HIV+ pregnant women-a governmental strategy to EMTCT first initiated in Malawi and now being expanded throughout the region...
November 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/28976064/benefits-and-extent-of-cam-use-among-persons-living-with-hiv-attending-an-antiretroviral-therapy-clinic-in-warri-nigeria
#16
Ufuoma S Ahwinahwi, Valentine U Odili, Jeremiah Ogubere
PURPOSE: The objective of this study was to assess the use of complementary and alternative medicine (CAM) therapies among patients on anti-retroviral therapies as well as the possible reasons for their use. METHOD: This cross-sectional survey was conducted with the aid of an interviewer-administered questionnaire on HIV-positive patients attending the antiretroviral therapy clinic (Heart-to-Heart centre) of the Central Hospital, Warri, Nigeria. Patients who were 18 years and over were included after a brief introductory talk on the nature of the study...
October 4, 2017: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28966741/electrolyte-imbalance-and-sleep-problems-during-anti-retroviral-therapy-an-under-recognized-problem
#17
Md Dilshad Manzar, Peter Sony, Mohammed Salahuddin, Abera Kumalo, Mathewos Geneto, Seithikurippu R Pandi-Perumal, Adam Moscovitch, Ahmed S BaHammam
Human immunodeficiency virus (HIV) infection, and the anti-retroviral therapy (ART) associated complications necessitate that the medical care system keeps evolving for proper management of this group of patients. Electrolyte imbalance and sleep problems are common in patients on ART. Both of these conditions are associated with increased morbidity (such as acute kidney injury, chronic kidney disease, low CD4 count, non-adherence and depression) and mortality. Therefore, screening for both sleep problems and electrolytes imbalance may help to decrease the risk of complications in patients on ART...
April 2017: Sleep Science
https://www.readbyqxmd.com/read/28953324/clinical-utility-of-hcv-core-antigen-detection-and-quantification-using-serum-samples-and-dried-blood-spots-in-people-who-inject-drugs-in-dar-es-salaam-tanzania
#18
Zameer Mohamed, Jessie Mbwambo, Yusuke Shimakawa, Lila Poiteau, Stéphane Chevaliez, Jean-Michel Pawlotsky, John Rwegasha, Sanjay Bhagani, Taylor-Robinson Simon D, Julie Makani, Mark R Thursz, Maud Lemoine
INTRODUCTION: A lack of access to hepatitis C virus (HCV) diagnostics is a significant barrier to achieving the World Health Organization 2030 global elimination goal. HCV core antigen (HCVcAg) quantification and dried blood spot (DBS) are appealing alternatives to conventional HCV serology and nucleic acid testing (NAT) for resource-constraint settings, particularly in difficult-to-reach populations. We assessed the accuracy of serum and DBS HCVcAg testing in people who inject drugs in Tanzania using HCV NAT as a reference...
September 19, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28945911/hdl-cholesterol-efflux-capacity-in-newly-diagnosed-hiv-and-effects-of-antiretroviral-therapy
#19
Mabel Toribio, Min Hi Park, Markella V Zanni, Gregory K Robbins, Tricia H Burdo, Kenneth C Williams, Meghan N Feldpausch, Lauren Stone, Kathleen Melbourne, Steven K Grinspoon, Michael L Fitzgerald
Context: In the general population, high-density lipoprotein (HDL) cholesterol efflux capacity (HCEC) relates inversely to incident cardiovascular events. Previous studies have suggested that HCEC is decreased in HIV and that antiretroviral therapy (ART) initiation might improve HCEC. Objective: To evaluate HCEC in the context of ART initiation and immune activation in HIV. Design and Outcome Measures: Baseline HCEC from 10 ART-naive HIV-infected males and 12 prospectively matched non-HIV-infected males were analyzed...
November 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28944075/efficacy-of-switching-to-dolutegravir-plus-rilpivirine-the-small-tablet-regimen-in-patients-with-dysphagia-two-case-reports
#20
Takefumi Suzuki, Nobuko Hara, Morichika Osa, Kazuhisa Misawa, Kazuo Imai, Yuji Fujikura, Takuya Maeda, Wataru Sonehara, Akihiko Kawana
BACKGROUND: The advent of well-tolerated and effective anti-retroviral drugs against human immunodeficiency virus-1 (HIV-1) infection has been a major step forward that has achieved long-term survival in recent years. The number of HIV-1 infected patients who experience difficulty in swallowing tablets is expected to increase as the HIV-infected population advances in age or develops comorbidities or treatment sequelae affecting the central nervous system. CASE PRESENTATION: Here, we describe two HIV-1-infected patients who experienced progressive dysphagia leading to inability to swallow the antiretroviral tablets included in the standard regimen...
2017: Journal of Pharmaceutical Health Care and Sciences
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