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https://www.readbyqxmd.com/read/29679628/long-and-short-term-outcomes-of-gestational-diabetes-mellitus-gdm-among-south-asian-women-a-community-based-study
#1
REVIEW
B H Sudasinghe, C N Wijeyaratne, P S Ginige
AIMS: To quantify short and long-term outcomes of Gestational Diabetes Mellitus (GDM) among South Asians METHODS: Prospective cohort-study in Gampaha District, Sri Lanka following a community-prevalence study (WHO 1999 criteria). All women with GDM (exposed) and within sample non-GDM (non-exposed) were recruited. Data was gathered at selected intervals until one-year post-partum by interviewer-administered questionnaire, anthropometry, blood pressure, post-partum 75gOGTT and cholesterol...
April 18, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29679625/nutrition-therapy-within-and-beyond-gestational-diabetes
#2
REVIEW
Teri L Hernandez, Archana Mande, Linda A Barbour
With the global rising prevalence of gestational diabetes (GDM), an adaptable, economical approach to nutrition therapy that effectively controls maternal glycemia while promoting normal fetal growth will have far-reaching implications. The conventional focus has been to rigidly limit all types of carbohydrate. While controlling glucose, this approach fosters maternal anxiety and is a primary barrier to adherence. Many mothers substitute fat for carbohydrate, which may unintentionally enhance lipolysis, promote elevated free fatty acids (FFA), and worsen maternal insulin resistance (IR)...
April 18, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29679624/perspectives-on-diagnostic-strategies-for-hyperglycemia-in-pregnancy-dealing-with-the-barriers-and-challenges-in-china
#3
Yumei Wei, Huixia Yang
Hyperglycemia is one of the most common medical conditions women encounter during pregnancy. Hyperglycemia in pregnancy (HIP) is an issue of increasing concern to both obstetricians and administrators and it brings health issues for both mothers and offspring, not only early complications, but also long-term effects. HIP may either have been pre-gestational diabetes mellitus (pGDM), or gestational diabetes mellitus (GDM). After two-child policy fully carried out in China, the incidence of HIP would be increased further...
April 18, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29679623/hyperglycemia-in-pregnancy-and-its-implications-for-a-woman-s-future-risk-of-cardiovascular-disease
#4
REVIEW
Ravi Retnakaran
It is well established that gestational diabetes mellitus (GDM) identifies a population of women who are at risk of ultimately developing type 2 diabetes (T2DM) later in life. Moreover, this relationship extends across the full spectrum of hyperglycemia in pregnancy, with lesser degrees of gestational dysglycemia identifying a proportionate gradient of future risk of T2DM. Importantly, a growing body of evidence suggests that an analogous relationship exists between hyperglycemia in pregnancy and a woman's long-term risk of cardiovascular disease (CVD), as well...
April 18, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29679622/pharmacotherapy-for-hyperglycemia-in-pregnancy-do-oral-agents-have-a-place
#5
REVIEW
Rosa Corcoy, Montserrat Balsells, Apolonia García-Patterson, Anat Shmueli, Eran Hadar
Diabetes is a frequent condition in pregnancy and achieving adequate glycemic control is of paramount importance. Insulin treatment is the gold standard, oral agents are more attractive, but their safety and efficiency should be a prerequisite for their use. We have more information regarding treatment of women with gestational diabetes mellitus where glyburide can induce a picture of fetal hyperinsulinism (higher birthweight and more neonatal hypoglycemia) whereas metformin requires supplemental insulin in a larger proportion of women but achieves satisfactory perinatal outcomes with the exception of preterm birth...
April 18, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29679617/retinopathy-of-prematurity-a-review-of-risk-factors-and-their-clinical-significance
#6
REVIEW
Sang Jin Kim, Alexander D Port, Ryan Swan, J Peter Campbell, R V Paul Chan, Michael F Chiang
Retinopathy of prematurity (ROP) is a retinal vasoproliferative disease that affects premature infants. Despite improvements in neonatal care and management guidelines, ROP remains a leading cause of childhood blindness worldwide. Current screening guidelines are primarily based on two risk factors: birth weight and gestational age; however, many investigators have suggested other risk factors, including maternal factors, prenatal and perinatal factors, demographics, medical interventions, comorbidities of prematurity, nutrition, and genetic factors...
April 19, 2018: Survey of Ophthalmology
https://www.readbyqxmd.com/read/29679529/influence-of-human-milk-and-parenteral-lipid-emulsions-on-serum-fatty-acid-profiles-in-extremely-preterm-infants
#7
Anders K Nilsson, Chatarina Löfqvist, Svetlana Najm, Gunnel Hellgren, Karin Sävman, Mats X Andersson, Lois E H Smith, Ann Hellström
BACKGROUND: Infants born prematurely are at risk of a deficiency in ω-6 and ω-3 long-chain polyunsaturated fatty acids (LC-PUFAs) arachidonic acid (AA) and docosahexaenoic acid (DHA). We investigated how fatty acids from breast milk and parenteral lipid emulsions shape serum LC-PUFA profiles in extremely preterm infants during early perinatal life. METHODS: Ninety infants born < 28 weeks gestational age were randomized to receive parenteral lipids with or without the ω-3 LC-PUFAs eicosapentaenoic acid (EPA) and DHA (SMOFlipid: Fresenius Kabi, Uppsala, Sweden, or Clinoleic: Baxter Medical AB, Kista, Sweden, respectively)...
April 21, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29679395/placental-adaptations-to-micronutrient-dysregulation-in-the-programming-of-chronic-disease
#8
Pierre Hofstee, Daniel McKeating, Anthony V Perkins, James S M Cuffe
Poor nutrition during pregnancy is known to impair foetal development and increase the risk of chronic disease in offspring. Both macronutrients and micronutrients are required for a healthy pregnancy although significantly less is understood about the role of micronutrients in the programming of chronic disease. This is despite the fact that modern calorie rich diets are often also deficient in key micronutrients. The importance of micronutrients in gestational disorders is clearly understood but how they impact long term disease in humans requires further investigation...
April 21, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29679053/pregnancy-associated-diamine-oxidase-originates-from-extravillous-trophoblasts-and-is-decreased-in-early-onset-preeclampsia
#9
Philipp Velicky, Karin Windsperger, Karin Petroczi, Sophie Pils, Birgit Reiter, Tamara Weiss, Sigrid Vondra, Robin Ristl, Sabine Dekan, Christian Fiala, David E Cantonwine, Thomas F McElrath, Bernd Jilma, Martin Knöfler, Thomas Boehm, Jürgen Pollheimer
Human extravillous trophoblast (EVT) invasion of the pregnant uterus constitutes a pivotal event for the establishment of the maternal-fetal interface. Compromised EVT function manifesting in inadequate arterial remodeling is associated with the severe pregnancy disorder early-onset preeclampsia (eoPE). Recent studies suggest that EVTs invade the entire uterine vasculature including arteries, veins and lymphatics in the first trimester of pregnancy. We therefore hypothesized that EVT-derived factors accumulate in the circulation of pregnant women early in gestation and may serve to predict eoPE...
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29679045/trends-in-the-neurodevelopmental-outcomes-among-preterm-infants-from-2003-2012-a-retrospective-cohort-study-in-japan
#10
Hidehiko Nakanishi, Hideyo Suenaga, Atsushi Uchiyama, Yumi Kono, Satoshi Kusuda
OBJECTIVES: To determine the trends in mortality and the prevalence of abnormal neurodevelopmental outcomes among preterm Japanese infants. STUDY DESIGN: A retrospective multicenter cohort of 30,793 preterm infants born at a gestational age ≤32 weeks, between 2003 and 2012, in the Neonatal Research Network, Japan, was evaluated in the primary analysis. Finally, 13,661 infants were followed-up until 3 years of age and evaluated for neurodevelopmental outcomes, including cerebral palsy (CP), home oxygen therapy (HOT) use, and visual, hearing, and cognitive impairments...
April 20, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29679039/postprandial-glycemic-control-during-gestational-diabetes-pregnancy-predicts-the-risk-of-recurrence
#11
Naama Schwartz, Manfred S Green, Enav Yefet, Zohar Nachum
In this study we aimed to explore the significance of glycemic control during gestational diabetes mellitus (GDM) pregnancy in predicting recurrence as this is unknown. A retrospective population-based cohort study of women with first diagnosed GDM pregnancy was conducted. A total of 426 women with 4,226 glucose charts were obtained. Daily glucose values were collected from the glucose charts. Non-parametric (LOWESS) regression was used to present the glucose measurements along the gestational weeks. The analyses revealed that the 2-hour postprandial levels among women with GDM recurrence were substantially higher throughout gestation (PR = 1...
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29678840/micronuclei-induction-in-amniotic-fluid-cells-from-cyclophosphamide-treated-rats
#12
Karen Gomez-Mariscal, Belinda C Gómez-Meda, Ana L Zamora-Perez, María G Sánchez-Parada, Martha P Gallegos-Arreola, Guillermo M Zúñiga-González
The aim of the study was to determine if amniotic fluid cells of rats can be used to provide evidence of genotoxicity. In order to do that micronuclei formation was induced in rats during pregnancy after treatment with cyclophosphamide (CP), at different CP doses. On gestational day 19, we collected the amniotic fluid and determined the frequency of micronucleated cells (MNCs) from the offspring. Samples were centrifuged and placed on clean slides. The smears were observed with an epifluorescence microscope...
March 2018: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29678771/prenatal-ethanol-induces-an-anxiety-phenotype-and-alters-expression-of-dynorphin-nociceptin-orphanin-fq-genes
#13
Aranza Wille-Bille, Roberto Sebastián Miranda-Morales, Mariangela Pucci, Fabio Bellia, Claudio D'Addario, Ricardo Marcos Pautassi
Animal models have suggested that prenatal ethanol exposure (PEE) alters the κ opioid receptor system. The present study investigated the brain expression of dynorphin and nociceptin/orphanin FQ related genes and assessed anxiety-like behavior in the light-dark box (LDB), shelter-seeking and risk-taking behaviors in the concentric square field (CSF) test, and ethanol-induced locomotion in the open field (OF), in infant or adolescent Wistar rats that were exposed to PEE (0.0 or 2.0 g/kg, intragastrically, gestational days 17-20)...
April 17, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29678709/metastatic-non-gestational-choriocarcinoma-to-the-brain-a-case-report-and-proposed-treatment-recommendations
#14
Jason Duong, Hammad Ghanchi, Dan Miulli, Avneet Kahlon
OBJECTIVE: Non-gestational choriocarcinoma (NGC) is a rare germ cell tumor, reported less than 0.6% of all gestational tumors, and has a poor prognosis when metastasized. NGC is even less reported with metastasis to the brain. Gestational choriocarcinoma (GC) when metastasized to the brain has a higher morbidity and mortality but has been known to be a chemosensitive and radiosensitive lesion, and NGC is chemoresistant with an even worse prognosis. Currently, there is no consensus for treatment for metastatic NGC to the brain...
April 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29678412/awareness-of-listeriosis-and-methylmercury-toxicity-public-health-recommendations-and-diet-during-pregnancy
#15
Shao Jia Zhou, Rebecca L Greco, Rosalie Grivell, Jennie Louise, Andrea Deussen, Jodie Dodd, Lisa J Moran
BACKGROUND: Awareness of Listeriosis and Methylmercury toxicity recommendations are associated with decreased intake of high-risk foods. Whether awareness of the recommendations affect dietary quality of pregnant women in Australian is unknown. AIM: To evaluate awareness of Listeriosis and Methylmercury toxicity recommendations during pregnancy and its impact on dietary quality. METHODS: Pregnant women (n=81) were recruited from antenatal clinics...
April 17, 2018: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/29678409/phototherapy-for-neonatal-hyperbilirubinemia-and-childhood-eczema-rhinitis-and-wheeze
#16
Elizabeth Huiwen Tham, Evelyn Xiu Ling Loo, Anne Goh, Oon Hoe Teoh, Fabian Yap, Kok Hian Tan, Keith M Godfrey, Hugo Van Bever, Bee Wah Lee, Yap Seng Chong, Lynette Pei-Chi Shek
BACKGROUND: The pathogenesis of allergic diseases in childhood may be attributed to influences of early environmental stimuli on fetal and neonatal immune regulation. Neonatal hyperbilirubinemia is common in the Asian population and up to 20% of infants require phototherapy. We examined the hypothesis that phototherapy for neonatal hyperbilirubinemia modulates the infant's risk of developing eczema, rhinitis and wheeze in the Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort...
March 24, 2018: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29678353/the-predictive-value-of-the-sflt-1-plgf-ratio-on-short-term-absence-of-preeclampsia-and-maternal-and-fetal-or-neonatal-complications-in-twin-pregnancies
#17
Langeza Saleh, Sarea I M Tahitu, A H Jan Danser, Anton H van den Meiracker, Willy Visser
OBJECTIVE: A sFlt-1/PlGF ratio of ≤38 has been reported to predict the absence of preeclampsia (PE) in singleton pregnancies. We evaluated whether a sFlt-1/PlGF ratio of ≤38 could be used to predict the absence of PE in twin pregnancies and maternal and fetal/neonatal complications. METHODS: This is a secondary analysis of a prospective multicenter cohort study that enrolled women with suspected or confirmed PE with the aim of evaluating the use of the sFlt-1, PlGF and their ratio to predict maternal and fetal/neonatal complications...
March 26, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29678332/gestational-aging-and-determination-of-parturition-date-in-the-bitch-and-queen-using-ultrasonography-and-radiography
#18
REVIEW
Cheryl Lopate
This article provides a complete understanding of how radiography and ultrasound imaging can be used to determine gestational age when inadequate breeding data are available. Formulas for calculation of gestational age using both fetal and extrafetal structures are presented. Ultrasonographic descriptions of organ development and their use in determining gestational age are discussed. This information may be used to monitor the health and development of the fetuses and may be useful when the need to plan an elective or emergency Cesarean section occurs...
April 17, 2018: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/29677687/endothelial-dysfunction-as-a-long-term-effect-of-late-onset-hypertensive-pregnancy-disorders-high-bmi-is-key
#19
L J Alma, C J M De Groot, R X De Menezes, W Hermes, P L Hordijk, I Kovačević
OBJECTIVE: Hypertensive disorders during pregnancy increase cardiovascular risk later in life by 2 to 9-fold. Endothelial activation is one of the underlying mechanisms of cardiovascular risk. Therefore, we decided to investigate endothelial activation in primiparous women, 2.5 years after a hypertensive pregnancy disorder. STUDY DESIGN: Plasma samples were taken from women 2.5 years after gestational hypertension (GH) or late onset preeclampsia (cases) and from women 2...
April 12, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29677638/gestational-glucocorticoid-exposure-disrupts-glucose-homeostasis-that-is-accompanied-by-increased-endoglin-and-dpp-4-activity-instead-of-gsk-3-in-rats
#20
Olufunto O Badmus, Olugbenga S Michael, Saheed Rabiu, Lawrence A Olatunji
Gestational glucocorticoid (GC) treatment has been associated with cardiometabolic disorder (CMD) in offspring's in later life. Elevated dipeptidyl peptidase-4 (DPP-4) activity, endoglin and glycogen synthase kinase-3 (GSK-3) has also been implicated in the development of insulin resistance (IR) and/or vascular inflammation. We aimed to investigate the impact of GC exposure on glucose metabolism and the circulating levels of inflammatory biomarkers, DPP-4 activity and GSK-3 in pregnant rats. Pregnant Wistar rats received either vehicle or dexamethasone (DEX; 0...
April 13, 2018: Environmental Toxicology and Pharmacology
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