Philipp Velicky, Karin Windsperger, Karin Petroczi, Sophie Pils, Birgit Reiter, Tamara Weiss, Sigrid Vondra, Robin Ristl, Sabine Dekan, Christian Fiala, David E Cantonwine, Thomas F McElrath, Bernd Jilma, Martin Knöfler, Thomas Boehm, Jürgen Pollheimer
Human extravillous trophoblast (EVT) invasion of the pregnant uterus constitutes a pivotal event for the establishment of the maternal-fetal interface. Compromised EVT function manifesting in inadequate arterial remodeling is associated with the severe pregnancy disorder early-onset preeclampsia (eoPE). Recent studies suggest that EVTs invade the entire uterine vasculature including arteries, veins and lymphatics in the first trimester of pregnancy. We therefore hypothesized that EVT-derived factors accumulate in the circulation of pregnant women early in gestation and may serve to predict eoPE...
April 20, 2018: Scientific Reports