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Breast sentinel lymph node metastasis

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https://www.readbyqxmd.com/read/28797030/one-step-nucleic-acid-amplification-assay-is-an-accurate-technique-for-sentinel-lymph-node-biopsy-of-breast-cancer-patients-a-meta-analysis
#1
Fang Shi, Qian Zhang, Zhenzhen Liang, Mengmeng Zhang, Xin Liu
BACKGROUND: To estimate the accuracy of one-step nucleic acid amplification (OSNA) assay as an intra-operative sentinel lymph node biopsy (SLNB) for sentinel lymph node (SLN) metastasis in breast cancer. METHODS: PubMed, Cochrane Library and Web of Science databases were searched by two independent reviewers to retrieve literature with per-patient analysis. The deadline was up until December 2016. A meta-analysis was performed using STATA, Meta-Disc, and Revman software...
August 10, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28766210/positive-ultrasound-guided-lymph-node-needle-biopsy-in-breast-cancer-may-not-mandate-axillary-lymph-node-dissection
#2
Christine K Harris, Hanh Tam Tran, Katherine Lee, Charles Mylander, Daina Pack, Martin Rosman, Lorraine Tafra, Christopher B Umbricht, Reema Andrade, Wen Liang, Rubie Sue Jackson
BACKGROUND: The ACOSOG Z0011 (Z11) trial demonstrated that in patients with nonpalpable axillary lymph nodes (LN) and one to two positive sentinel LN (SLN), axillary LN dissection (ALND) is unnecessary.JAMA 305:569-575, [2011], Ann Surg 264:413-42, [2016] The Z11 trial did not require preoperative axillary ultrasound (axUS). In many centers, preoperative axUS is part of the standard workup of a newly diagnosed breast cancer patient, but in light of the Z11 results, its role is now questioned...
August 1, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28763628/the-value-of-18f-fdg-pet-ct-imaging-in-breast-cancer-staging
#3
Ulkem Yararbas, Neslihan Çetin, Levent Yeniay, Aziz Murat Argon
The National Comprehensive Cancer Network (NCCN) guidelines recommend assessment with positron emission tomography with 2-deoxy-2-[fluorine-18]fluoro- D-glucose integrated with computed tomography (18F-FDG PET/CT) in staging of breast cancer, starting from the stage IIIA. Previously, PET/CT contributed to the accurate staging from the stage IIB. Our aim is to evaluate the contribution of 18F-FDG PET/CT in staging of breast cancer patients. A total of 234 patients were retrospectively evaluated. PET/CT was performed preoperatively in 114/234 and postoperatively in 120/234 patients...
August 1, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28748712/association-between-us-features-of-primary-tumor-and-axillary-lymph-node-metastasis-in-patients-with-clinical-t1-t2n0-breast-cancer
#4
Min Sun Bae, Sung Ui Shin, Sung Eun Song, Han Suk Ryu, Wonshik Han, Woo Kyung Moon
Background Most patients with early-stage breast cancer have clinically negative lymph nodes (LNs). However, 15-20% of patients have axillary nodal metastasis based on the sentinel LN biopsy. Purpose To assess whether ultrasound (US) features of a primary tumor are associated with axillary LN metastasis in patients with clinical T1-T2N0 breast cancer. Material and Methods This retrospective study included 138 consecutive patients (median age = 51 years; age range = 27-78 years) who underwent breast surgery with axillary LN evaluation for clinically node-negative T1-T2 breast cancer...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28735457/impact-of-sentinel-lymph-node-biopsy-by-ultrasound-guided-core-needle-biopsy-for-patients-with-suspicious-node-positive-breast-cancer
#5
Rikiya Nakamura, Naohito Yamamoto, Toshiko Miyaki, Makiko Itami, Nobumitsu Shina, Masayuki Ohtsuka
PURPOSE: The purpose of this study was to investigate the accuracy of preoperative diagnostic tools for axillary lymph nodes (LNs) staging of breast cancer. MATERIALS AND METHODS: A total of 2464 consecutive patients with operable breast cancer were prospectively identified at our institution between April 2012 and March 2017. Patients with suspicious axillary LN of breast cancer were assessed using preoperative ultrasound(US) or computed tomography (CT), underwent fine-needle aspiration cytology (FNA) or core needle biopsy (CNB)...
July 22, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/28718896/nomograms-for-preoperative-prediction-of-axillary-nodal-status-in-breast-cancer
#6
L Dihge, P-O Bendahl, L Rydén
BACKGROUND: Axillary staging in patients with breast cancer and clinically node-negative disease is performed by sentinel node biopsy (SLNB). The aim of this study was to integrate feasible preoperative variables into nomograms to guide clinicians in stratifying treatment options into no axillary staging for patients with non-metastatic disease (N0), SLNB for those with one or two metastases, and axillary lymph node dissection (ALND) for patients with three or more metastases. METHODS: Patients presenting to Skåne University Hospital, Lund, with breast cancer were included in a prospectively maintained registry between January 2009 and December 2012...
July 18, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28697552/the-importance-of-tattoo-pigment-in-sentinel-lymph-nodes
#7
Atilla Soran, Ebru Menekse, Amal Kanbour-Shakir, Kaori Tane, Emilia Diego, Marguerite Bonaventura, Ronald Johnson
BACKGROUND: The presence of pigment in axillary lymph nodes (LN) secondary to migration of tattoo ink can imitate the appearance of a blue sentinel lymph node (SLN) on visual inspection, causing the operator to either miss the true SLN or excise more than is needed. OBJECTIVE: We present patients with tattoos ipsilateral to an early stage breast cancer who underwent a SLN biopsy. METHODS: Patients were retrospectively reviewed from medical records and clinicopathologic data was collected...
July 6, 2017: Breast Disease
https://www.readbyqxmd.com/read/28690104/a-clinical-perspective-on-regional-nodal-irradiation-for-breast-cancer
#8
Amy C Moreno, Simona F Shaitelman, Thomas A Buchholz
The goal of regional treatments in breast cancer should be to eradicate any disease within lymph nodes, avoid regional recurrences, minimize the risk of distant metastases, and improve survival. In addition, regional treatments should focus on reducing potential morbidities and optimizing the long-term quality of life of breast cancer survivors. While data from recent surgical and radiation trials have helped clarify many issues regarding regional treatment, there still remains controversy as to the optimal approach for patients with "intermediate risk" disease...
July 6, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28677240/application-of-automated-image-analysis-reduces-the-workload-of-manual-screening-of-sentinel-lymph-node-biopsies-in-breast-cancer
#9
Henrik Holten-Rossing, Maj-Lis Møller Talman, Anne Marie Bak Jylling, Anne-Vibeke Laenkholm, Martin Kristensson, Ben Vainer
INTRODUCTION: Breast cancer is one of the most common cancer diseases in women with more than 1.67 million cases diagnosed worldwide each year. In breast cancer, the sentinel lymph node (SLN) pinpoints the first lymph node(s) into which the tumor spreads and it is usually located in the ipsilateral axilla. In patients with no clinical signs of metastatic disease in the axilla, a SLN biopsy (SLNB) is performed. Assessment of metastases in the SLNB is done in a conventional microscope by manually observing a metastasis and measuring its size and/or counting the number of tumor cells...
July 5, 2017: Histopathology
https://www.readbyqxmd.com/read/28667103/expression-and-prognostic-value-of-her-2-neu-in-primary-breast-cancer-with-sentinel-lymph-node-metastasis
#10
Zhen-Jun Tong, Ning-Yao Shi, Zhi-Ji Zhang, Xiao-Dong Yuan, Xiao-Ming Hong
The present study explores the correlation of human epidermal growth factor receptor-2 (HER-2) protein expression with sentinel lymph node (SLN) metastasis and prognosis of breast cancer. The breast cancer tissues and adjacent tissues were obtained from patients with primary breast cancer. Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to detect the mRNA level of HER-2. Spearman correlation analysis was used to analyze the correlation of HER-2 expression with SLN metastasis. The disease-free survival (DFS) and overall survival (OS) of breast cancer patients were investigated...
August 31, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28629690/axillary-lymph-node-sonographic-features-and-breast-tumor-characteristics-as-predictors-of-malignancy-a-nomogram-to-predict-risk
#11
Patricia Akissue de Camargo Teixeira, Luciano F Chala, Carlos Shimizu, José R Filassi, Jonathan Y Maesaka, Nestor de Barros
The purpose of this study was to build a mathematical model to predict the probability of axillary lymph node metastasis based on the ultrasonographic features of axillary lymph nodes and the tumor characteristics. We included 74 patients (75 axillae) with invasive breast cancer who underwent axillary ultrasonography ipsilateral to the tumor and fine-needle aspiration of one selected lymph node. Lymph node pathology results from sentinel lymph node biopsy or surgical dissection were correlated with lymph node ultrasonographic data and with the cytologic findings of fine-needle aspiration...
June 16, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28626128/a-case-of-matrix-producing-carcinoma-of-the-breast
#12
Yuzuru Inoue, Fumi Joden, Kei Yabuki, Nagahiro Sato, Noritaka Minagawa, Takefumi Katsuki, Norihiro Sato, Takahisa Nagata, Kazunori Shibao, Atsuji Matsuyama, Takatoshi Aoki, Keiji Hirata
A 61-year-old woman was referred to our hospital because of a right breast mass. A 19 mm hard mass was palpable in the A area of the right breast. A contrast-enhanced MRI showed rim enhancement at the peripheral region of the tumor, which was thought to represent the carcinoma component mainly at the periphery and the matrix component inside the tumor. A low density mass with rim enhancement at the peripheral region was observed in a contrast-enhanced CT, the same as in the MRI. Neither axillary lymph node metastasis nor distant metastasis was observed...
2017: Journal of UOEH
https://www.readbyqxmd.com/read/28608612/factors-impacting-the-accuracy-of-intra-operative-evaluation-of-sentinel-lymph-nodes-in-breast-cancer
#13
Catherine L Akay, Constance Albarracin, Tiffany Torstenson, Roland Bassett, Elizabeth A Mittendorf, Min Yi, Henry M Kuerer, Gildy V Babiera, Isabelle Bedrosian, Kelly K Hunt, Rosa F Hwang
Sentinel lymph node dissection (SLND) is a standard axillary staging technique in breast cancer and intraoperative sentinel lymph node (SLN) assessment is important for decision-making regarding additional treatment and reconstruction. This study was undertaken to investigate clinicopathologic factors impacting the accuracy of intraoperative SLN evaluation. Records of patients with clinically node-negative, invasive breast cancer who underwent SLND with frozen section intraoperative pathologic evaluation from 2004 to 2007 were reviewed...
June 13, 2017: Breast Journal
https://www.readbyqxmd.com/read/28608456/is-axillary-surgery-beneficial-for-patients-with-adenoid-cystic-carcinoma-of-the-breast
#14
Jessemae L Welsh, Michael G Keeney, Tanya L Hoskin, Katrina N Glazebrook, Judy C Boughey, Sejal S Shah, Tina J Hieken
BACKGROUND AND OBJECTIVES: Adenoid cystic carcinoma (ACC) is a rare, typically triple-negative, breast cancer reported to have a favorable prognosis and low rate of nodal metastasis. No consensus guidelines exist for axillary staging and treatment. METHODS: We identified all patients with ACC evaluated at our institution from January 1994 to August 2016. Patient, tumor, and treatment variables were abstracted and analyzed. RESULTS: We identified 20 pure ACCs (0...
June 12, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28576464/prognostic-impact-of-macrometastasis-linear-size-in-sentinel-node-biopsy-for-breast-carcinoma
#15
M P Foschini, R Miglio, C Quinn, B Belgio, P Regitnig, S Bianchi, R Nannini, H Buerger, H Kaya, I Illyés, J Kulka, C A Wells, J De Gaetano, I Lipeniece-Karele, G Cserni
AIM: The aim of the present study was to evaluate the risk of axillary non-sentinel lymph-node metastases (ALN) in breast cancer patients presenting macrometastasis (Mac-m) in the sentinel lymph node (SN). MATERIALS AND METHODS: A retrospective series of 1464 breast cancers from patients who underwent ALN dissection following the diagnosis of Mac-m in the sentinel node (SN) was studied. In all the cases the MAC-m linear size was evaluated and correlated with presence or absence of non-SN ALN metastases...
May 17, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28546702/efficacy-of-sentinel-lymph-node-biopsy-in-detecting-axillary-metastasis-in-breast-cancer-using-methylene-blue
#16
Vipul V Nandu, Milind S Chaudhari
Breast cancer is the leading malignancy and the second leading cause of cancer-related deaths. Axillary lymph node status is a very important prognostic factor in breast cancer patients; nodal evaluation is therefore a critical part of breast cancer management. Axillary lymph node dissection results in significant morbidity. Sentinel lymph node biopsy (SLNB) is being used in many centers to stage the axilla in planning axillary dissection management of patients and hence plays an important part in reducing morbidity among patients with carcinoma breast...
June 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28510222/primary-ectopic-breast-cancer-of-the-vulva-treated-with-local-excision-of-the-vulva-and-sentinel-lymph-node-biopsy-a-case-report
#17
Takayuki Ishigaki, Yasuo Toriumi, Ryouko Nosaka, Rei Kudou, Yoshimi Imawari, Makiko Kamio, Hiroko Nogi, Hisashi Shioya, Hiroshi Takeyama
Primary breast cancer fairly infrequently occurs in ectopic breast tissue, and primary ectopic breast cancer of the vulva is particularly rare. Only 26 cases have been published in the English-language literature, and there has been no report of primary breast carcinoma of the vulva in Japan. We report a rare case of primary ectopic breast cancer of the vulva that was treated with local excision of the vulva and sentinel lymph node biopsy (SLNB). The patient was a 72-year-old woman who had noticed a right vulvar tumor 10 years earlier...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28503075/imprint-cytology-versus-frozen-section-analysis-for-intraoperative-assessment-of-sentinel-lymph-node-in-breast-cancer
#18
Thalia Petropoulou, Antonia Kapoula, Aikaterini Mastoraki, Aikaterini Politi, Eleni Spanidou-Karvouni, Ioannis Psychogios, Ioannis Vassiliou, Nikolaos Arkadopoulos
INTRODUCTION: Sentinel lymph node (SLN) biopsy is the gold standard for surgical staging of the axilla in breast cancer (BC). Frozen section (FS) remains the most popular means of intraoperative SLN diagnosis. Imprint cytology (IC) has also been suggested as a less expensive and equally accurate alternative to FS. The aim of our study was to perform a direct comparison between IC and FS on the same SLNs of BC cases operated in a single center by the same surgical team. MATERIALS AND METHODS: Into this prospective study we enrolled 60 consecutive patients with histologically proven T1-T3 BC and clinically negative axilla...
2017: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/28480185/intramammary-sentinel-lymph-node-with-capsular-extravasation-in-breast-cancer
#19
Paulo Roberto De Alcantara Filho, Carla Curi, Camila Souza Guatelli, Cynthia Aparecida B de Toledo Osorio, Stephania Martins Bezerra, Fernando Augusto Soares, Fabiana Baroni Makdissi
Sentinel lymph node biopsy has been developed as the standard of treatment in breast cancer. Status of axillary sentinel lymph node is known to be a significant prognostic factor. Nevertheless, involvement of an intramammary lymph node with metastasis in breast cancer is a rare radiological and clinical presentation, and with extracapsular extravasation even more uncommon. Historically, reported series of patients with intramammary lymph node diagnosed by final histological examination are small in number and clinical significance of metastasis is still unclear...
May 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/28473989/the-noninvasive-treatment-for-sentinel-lymph-node-metastasis-by-photodynamic-therapy-using-phospholipid-polymer-as-a-nanotransporter-of-verteporfin
#20
Kyosuke Shimada, Sachiko Matsuda, Hiromitsu Jinno, Noriaki Kameyama, Tomohiro Konno, Tsunenori Arai, Kazuhiko Ishihara, Yuko Kitagawa
Aim. The usefulness of photodynamic therapy (PDT) for treating sentinel lymph node (SLN) metastasis was evaluated. Materials and Methods. Verteporfin, a hydrophobic photosensitizer, forms a soluble aggregate with poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate) (PMB). The concentrations of verteporfin were determined by measuring the fluorescence emitted at 700 nm. Seven days after the inoculation of A431 cells at the forearm of BALB/c nude mice, PMB-verteporfin was injected at dorsum manus and 75 J of light energy was delivered for 1 minute...
2017: BioMed Research International
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