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Breast sentinel lymph node metastasis

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https://www.readbyqxmd.com/read/29774321/sentinel-lymph-node-metastasis-in-invasive-lobular-carcinoma-of-the-breast
#1
Hikmet Erhan Güven, Mahmut Onur Kültüroğlu, Mehmet Ali Gülçelik, Cihangir Özaslan
Objective: Invasive lobular carcinoma (ILC) of the breast makes up 5 to 15 percent of all invasive breast cancers. It has distinctive clinical and histopathological features when compared to invasive ductal carcinoma (IDC). This study intends to describe factors influencing sentinel lymph node (SLN) positivity in patients with "pure" ILC. Materials and Methods: Data of 105 patients, who were treated at a tertiary oncology center, with lobular carcinoma of the breast that were subjected to SLN biopsy was probed retrospectively...
April 2018: European Journal of Breast Health
https://www.readbyqxmd.com/read/29765119/elucidation-of-inhibitory-effects-on-metastatic-sentinel-lymph-nodes-of-breast-cancer-during-one-step-nucleic-acid-amplification
#2
Yoshiya Horimoto, Masahiko Tanabe, Saiko Kazuno, Yoshiki Miura, Kaoru Mogushi, Hiroshi Sonoue, Atsushi Arakawa, Kazunori Kajino, Toshiyuki Kobayashi, Mitsue Saito
One-step nucleic acid amplification (OSNA) is an established method for intraoperative diagnosis of breast cancer metastasis in sentinel lymph nodes, based on quantification of CK19 mRNA, specific to breast epithelial cells. Inhibitors interfere with the PCR amplification process of PCR. Thus, OSNA, based on gene amplification without RNA purification, might be impacted by numerous factors persisting in a sample, and thereby potentially acting as PCR inhibitors. However, neither the characteristics of breast cancers showing inhibitory effects during OSNA, nor any of the possible inhibitors, have as yet been identified...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29729704/detection-of-gene-expression-in-sentinel-lymph-node-of-primary-breast-cancer-patients
#3
Shahrzad Soleimani, Shohreh Alizadeh Shargh, Aliasghar Keramatinia, Narjes Mehrvar, Neda Mansouri, Abbas Doosti, Seyed Abdolreza Mortazavi-Tabatabaei, Mehrdad Hashemi, Abolfazl Movafagh
Sentinel lymph node (SLN) micrometstasis detection improves outcome for breast cancer follow up procedure. The aim of the present study was to identify gene profiles that accurately predicted the outcome of breast cancer patients. Fifty tumor sample from breast cancer patients were analyzed for the expression of 3 genes using quantitative-PCR. Also clinical verification for recurrence to distant organs was performed. Three gene signature were confirmed based on tumor's stage, grade, ER status, using conditional logistic regression...
April 30, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29707478/visualization-of-murine-lymph-vessels-using-photoacoustic-imaging-with-contrast-agents
#4
Ryo Nagaoka, Takuya Tabata, Shin Yoshizawa, Shin-Ichiro Umemura, Yoshifumi Saijo
Metastasis frequently occurs even in the early stage of breast cancer. This research studied the feasibility of using photoacoustic (PA) imaging for identifying metastasis in the lymph vessels of mice. The photoacoustic efficiency of various contrast agents was investigated, and the influence of scattered light was evaluated by using a lymph vessel phantom. The lymph vessels of mice were then visualized using the selected contrast agents: indocyanine green (ICG) and gold nanorods (AuNR). The attenuation of the PA imaging was -1...
March 2018: Photoacoustics
https://www.readbyqxmd.com/read/29700573/gamma-probe-and-ultrasound-guided-fine-needle-aspiration-cytology-of-the-sentinel-node-gulf-trial
#5
Daniëlle Verver, Charlotte M C Oude Ophuis, Lisa B Koppert, Cécile de Monyé, Carolien H M van Deurzen, Senada Koljenović, Annemarie Bruining, Bernies van der Hiel, Sylvia Ter Meulen, Alexander C J van Akkooi, Cornelis Verhoef, Dirk J Grünhagen
PURPOSE: Sentinel lymph node biopsy (SLNB) was introduced as a minimally invasive technique for nodal staging. Since associated morbidity is not negligible, it is highly relevant to pursue a more minimally invasive alternative. The purpose of this study was to prospectively evaluate the sensitivity of fine needle aspiration cytology (FNAC) with combined gamma probe and ultrasound (US) guidance in comparison with the gold standard histology of the sentinel node (SN) after SLNB for detecting metastasis...
April 26, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29696563/a-mathematical-prediction-model-incorporating-molecular-subtype-for-risk-of-non-sentinel-lymph-node-metastasis-in-sentinel-lymph-node-positive-breast-cancer-patients-a-retrospective-analysis-and-nomogram-development
#6
Na-Na Wang, Zheng-Jun Yang, Xue Wang, Li-Xuan Chen, Hong-Meng Zhao, Wen-Feng Cao, Bin Zhang
BACKGROUND: Molecular subtype of breast cancer is associated with sentinel lymph node status. We sought to establish a mathematical prediction model that included breast cancer molecular subtype for risk of positive non-sentinel lymph nodes in breast cancer patients with sentinel lymph node metastasis and further validate the model in a separate validation cohort. METHODS: We reviewed the clinicopathologic data of breast cancer patients with sentinel lymph node metastasis who underwent axillary lymph node dissection between June 16, 2014 and November 16, 2017 at our hospital...
April 25, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/29696472/axillary-lymph-node-evaluation-utilizing-convolutional-neural-networks-using-mri-dataset
#7
Richard Ha, Peter Chang, Jenika Karcich, Simukayi Mutasa, Reza Fardanesh, Ralph T Wynn, Michael Z Liu, Sachin Jambawalikar
The aim of this study is to evaluate the role of convolutional neural network (CNN) in predicting axillary lymph node metastasis, using a breast MRI dataset. An institutional review board (IRB)-approved retrospective review of our database from 1/2013 to 6/2016 identified 275 axillary lymph nodes for this study. Biopsy-proven 133 metastatic axillary lymph nodes and 142 negative control lymph nodes were identified based on benign biopsies (100) and from healthy MRI screening patients (42) with at least 3 years of negative follow-up...
April 25, 2018: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/29673015/analysis-of-246-sentinel-lymph-node-biopsies-of-patients-with-clinical-primary-breast-cancer-by-application-of-carbon-nanoparticle-suspension
#8
Shi-Xin Yang, Wen-Song Wei, Qi-Hua Jiang, Yu-Feng Zhou, Wei Qu, Jian-Hong Tu, Qian-Wen Ou-Yang, Zhi-Bing Zhou, Hao-Long Ding, Chun-Wei Xie
AIM: This study aims to explore the accuracy, specificity and laws of axillary lymph node metastasis predicted by sentinel lymph node biopsy (SLNB) by comparing axillary lymph node status via SLNB and axillary lymph node dissection (ALND) with nanocarbon as the tracer. METHODS: Forty six patients were retrospectively analyzed. These patients underwent SLNB with nanocarbon as the tracer from March 2013 to April 2014. RESULTS: Two hundred and forty six patients of sentinel lymph node (SLN) were successfully detected...
April 19, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29599329/additional-nodal-disease-prediction-in-breast-cancer-with-sentinel-lymph-node-metastasis-based-on-clinicopathological-features
#9
Paolo Orsaria, Emanuele Caredda, Federica Genova, Marco Materazzo, Ilaria Capuano, Gianluca Vanni, Alessandra Vittoria Granai, Adriano DE Majo, Ilaria Portarena, Pierpaolo Sileri, Giuseppe Petrella, Leonardo Palombi, Oreste Claudio Buonomo
AIM: The standard-of-care in breast cancer (BC) with positive sentinel lymph node (SLN) metastasis includes complete axillary lymph node dissection (ALND); however, almost half of such cases have no further tumor burden. This study aimed to assess the clinicopathological factors that predict non-SLN metastasis to define subgroups of SLN-positive patients in whom the axilla may be staged by SLN biopsy alone, while avoiding unnecessary overtreatment. PATIENTS AND METHODS: The records of 191 patients with histologically-proven primary BC who underwent a positive (SLN) biopsy between 2005 and 2017 were reviewed...
April 2018: Anticancer Research
https://www.readbyqxmd.com/read/29594495/evaluation-of-sentinel-lymph-node-biopsy-prior-to-axillary-lymph-node-dissection-the-role-of-isolated-tumor-cells-micrometastases-and-multifocality-multicentricity-a-retrospective-study-of-1214-breast-cancer-patients
#10
Lars Schröder, Roland Fricker, Roland Gregor Stein, Thomas Rink, Hartmut Fitz, Sebastian Blasius, Achim Wöckel, Thomas Müller
PURPOSE: Sentinel lymph node biopsy (SLNB) alone has thus become an accepted surgical approach for patients with limited axillary metastatic disease. We investigated to what extent isolated tumor cells (ITC) or micrometastasis in SLNBs is associated with proven tumor cells or metastasis in non-sentinel lymph nodes. Furthermore, we investigated the feasibility of SLNB in multifocal and multicentric tumors as both entities have been considered a contraindication for this technique. METHODS: 1214 women suffering from T1 and T2 invasive breast cancer, with clinically and sonographically insuspect axillary status and undergoing primary breast cancer surgery including SLNB and axillary staging in case of SLN (sentinel lymph node) metastases, were recruited into this multicentered study...
March 29, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29593307/morphology-of-immunomodulation-in-breast-cancer-tumor-draining-lymph-nodes-depends-on-stage-and-intrinsic-subtype
#11
Maximilian Seidl, Moritz Bader, Astrid Vaihinger, Ulrich F Wellner, Rumyana Todorova, Bettina Herde, Klaudia Schrenk, Jochen Maurer, Oliver Schilling, Thalia Erbes, Paul Fisch, Jens Pfeiffer, Linda Hoffmann, Kai Franke, Martin Werner, Peter Bronsert
Cancer research of immune-modulating mechanisms mainly addresses the role of tumor-infiltrating immune cells. Mechanisms modulating the adaptive immune system at the primary activation site - the draining lymph node (LN) - are less investigated. Here we present tumor-caused histomorphological changes in tumor draining LNs of breast cancer patients, dependent on the localization (sentinel LN vs. non-sentinel LN), the tumor size, the intrinsic subtype and nodal metastatic status. The quantitative morphological study was conducted in breast cancer patients with at least one sentinel LN and no neoadjuvant therapy...
March 28, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29574393/the-performance-of-one-step-nucleic-acid-amplification-assay-for-intraoperative-detection-of-sentinel-lymph-node-macrometastasis-in-breast-cancer-an-updated-meta-analysis
#12
Fang Shi, Zhenzhen Liang, Qian Zhang, Chunpeng Wang, Xin Liu
BACKGROUND: One-step nucleic acid amplification (OSNA) assay is a molecular diagnostic method for intraoperative detection of lymph node metastasis by amplifying cytokeratin 19 mRNA. We aim to further evaluate the performance of OSNA assay for the intraoperative diagnosis of sentinel lymph node metastasis in breast cancer. METHODS: PubMed, Cochrane Library, Web of Science databases were searched to retrieve related literature published up until December 2017. This meta-analysis was performed using a random-effects model...
March 22, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29558291/preoperative-axillary-us-in-early-stage-breast-cancer-potential-to-prevent-unnecessary-axillary-lymph-node-dissection
#13
Ga Ram Kim, Ji Soo Choi, Boo-Kyung Han, Jeong Eon Lee, Seok Jin Nam, Eun Young Ko, Eun Sook Ko, Se Kyung Lee
Purpose To evaluate the value of preoperative axillary ultrasonography (US) for preventing unnecessary axillary lymph node dissection after sentinel lymph node (SLN) biopsy in a large series of patients with early-stage breast cancers treated with both breast-conserving surgery and SLN biopsy. Materials and Methods From March 2009 to February 2013, 1802 patients who underwent breast-conserving surgery for clinical T1-2/N0 cancers and SLN biopsy with or without axillary lymph node dissection were included. Preoperative axillary US results and clinical-pathologic variables were compared according to the status of non-SLN metastasis...
March 20, 2018: Radiology
https://www.readbyqxmd.com/read/29536376/comparison-of-sentinel-lymph-node-biopsy-between-invasive-lobular-carcinoma-and-invasive-ductal-carcinoma
#14
Yayoi Adachi, Masataka Sawaki, Masaya Hattori, Akiyo Yoshimura, Noami Gondo, Haruru Kotani, Madoka Iwase, Ayumi Kataoka, Sakura Onishi, Kayoko Sugino, Mitsuo Terada, Nanae Horisawa, Makiko Mori, Isao Oze, Hiroji Iwata
BACKGROUND: Recent studies suggested that ALND (axillary lymph node dissection) can be avoided in breast cancer patients with limited SLN (sentinel lymph node) metastasis. However, these trials included only several invasive lobular carcinoma (ILC) cases, and the validity of omitting ALND for ILC remains controversial. Here, we examined whether omitting ALND is feasible in ILC treatment. METHODS: A total of 3771 breast cancer patients underwent surgery for breast cancer at the Aichi Cancer Center Hospital between January 2006 and December 2015...
March 13, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/29530065/predictive-factors-for-sentinel-node-metastases-in-primary-invasive-breast-cancer-a-population-based-cohort-study-of-2552-consecutive-patients
#15
Shabaz Majid, Lisa Rydén, Jonas Manjer
BACKGROUND: Axillary lymph node status is one of the most important prognostic factors for breast cancer. The aim of this study was to determine predictive factors for metastasis to sentinel node (SN) in primary invasive breast cancer. METHOD: This is a study of 3979 patients with primary breast cancer during 2008-2013 in Malmö and Lund scheduled for surgery and included in the information retrieved from Information Network for Cancer Care (INCA). The final study population included 2552 patients with primary invasive breast cancer...
March 12, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29526557/intracystic-papillary-carcinoma-of-the-breast-experience-of-a-major-chinese-cancer-center
#16
Jun Zhang, Tiemei Zhang, Nan Wu, Xinhua Zhao, Qingsong Wang, Yanyang Jiang, Ming Gao, Lin Gu
BACKGROUND: Intracystic papillary carcinoma (IPC) is a rare breast neoplasm. There are few studies focusing on its clinical features and limited data about its preoperative diagnosis,treatment and outcomes. The purpose of this study is to explore specific characteristics of patients with IPC, investigate its clinicopathological features, prognosis in China and confirm its surgery management. METHODS: We identified 111 patients with IPC from the registry of Tianjin Medical University Cancer Institute and Hospital between 2004 and 2017...
April 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29526019/systematic-versus-sentinel-lymph-node-driven-axillary-lymph-node-dissection-in-clinically-node-negative-patients-with-operable-breast-cancer-results-of-the-gf-gs01-randomized-trial
#17
P Roy, A Leizorovicz, R Villet, C Mercier, J Y Bobin
PURPOSE: Sentinel-lymph-node (SLN) resection seems to minimize systematic axillary-lymph-node dissection (sALND) side effects in operated breast cancer patients. We explored whether SLN resection achieves similar therapeutic outcomes as sALND but with fewer side effects. METHODS: A randomized, controlled, open-label trial with parallel-group design compared sALND restricted to cases with positive SLN biopsy (test arm, n = 774) versus SLN biopsy followed by sALND (control arm, n = 770)...
March 10, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29482783/evolution-in-sentinel-lymph-node-biopsy-in-breast-cancer
#18
REVIEW
Si-Qi Qiu, Guo-Jun Zhang, Liesbeth Jansen, Jakob de Vries, Carolien P Schröder, Elisabeth G E de Vries, Gooitzen M van Dam
Sentinel lymph node biopsy (SLNB) is the standard of care for axillary staging in clinically node-negative (cN0) breast cancer patients without neoadjuvant chemotherapy (NAC). The application of SLNB in patients receiving NAC has also been explored. Evidence supports its use after NAC in pretreatment cN0 patients. Nonetheless, its routine use in all the pretreatment node-positive patients who become cN0 after NAC is unjustified due to the unacceptably high false-negative rate, which can be improved in a subset of patients...
March 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29476580/the-case-for-the-omission-of-axillary-staging-in-invasive-breast-carcinoma-that-exhibits-a-predominant-tubular-growth-pattern-on-preoperative-biopsy
#19
Saed Ramzi, Elaine L Hyett, Abigail S Wheal, Peter J Cant
True invasive tubular breast carcinoma (TBC) is unlikely to metastasize to axillary nodes, yet it is routinely subjected to sentinel lymph node biopsy (SLNB), even if the diagnosis was suspected preoperatively. The positive predictive value (PPV) of core biopsy for TBC and the incidence and predictors of axillary metastasis in invasive breast carcinomas identified as tubular-rich on core biopsy are unknown. Prospective patient and tumor data regarding postoperatively confirmed TBCs, and tubular-rich carcinoma identified on preoperative core biopsy between January 2005 and May 2016 was analyzed retrospectively...
February 24, 2018: Breast Journal
https://www.readbyqxmd.com/read/29460095/diagnosis-characteristics-and-treatment-of-breast-carcinomas-within-benign-fibroepithelial-tumors
#20
Michiyo Saimura, Kenichiro Koga, Keisei Anan, Shoshu Mitsuyama, Sadafumi Tamiya
BACKGROUND: Breast carcinoma arising in a benign fibroepithelial tumor is rare, and is usually discovered incidentally during examination of the breast mass. METHODS: We evaluated the clinicopathological features, treatment, and prognosis of seven women with breast carcinomas within benign fibroepithelial tumors, diagnosed and treated at a single institution between 2011 and 2015. RESULTS: Seven women, aged 21-64 years, visited our hospital complaining of a breast mass detected by self-checking or screening examination...
February 19, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
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