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Breast sentinel lymph node metastasis

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https://www.readbyqxmd.com/read/28191804/does-alternative-and-traditional-wasam-local-cautery-therapy-facilitate-an-early-and-more-extensive-locoregional-metastasis-of-breast-cancer
#1
(no author information available yet)
INTRODUCTION: A large heterogeneous group of unproven remedies exist to treat cancer in both developed and developing countries. Some of these remedies often do more harm than good to the patients. The traditional medicine is the sum total of the knowledge, skills, and practices based on the theories, beliefs, and experiences indigenous to different cultures. The traditional medicine in Oman is based on herbal treatment and skin treatment (massage, Cupping and skin burn "cautery" treatment-known as Wasam or Kaiy)...
September 2016: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28173818/the-predictive-value-of-methylene-blue-dye-as-a-single-technique-in-breast-cancer-sentinel-node-biopsy-a-study-from-dharmais-cancer-hospital
#2
Bayu Brahma, Rizky Ifandriani Putri, Ramadhan Karsono, Bob Andinata, Walta Gautama, Lenny Sari, Samuel J Haryono
BACKGROUND: Axillary lymph node dissection (ALND) has been the standard treatment of breast cancer axillary staging in Indonesia. The limited facilities of radioisotope tracer and isosulfan or patent blue dye (PBD) have been the major obstacles to perform sentinel node biopsy (SNB) in our country. We studied the application of 1% methylene blue dye (MBD) alone for SNB to overcome the problem. METHODS: This prospective study enrolled 108 patients with suspicious malignant lesions or breast cancer stages I-III...
February 7, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28168389/can-clinically-node-negative-breast-cancer-patients-with-suspicious-axillary-lymph-nodes-at-ultrasound-but-negative-fine-needle-aspiration-be-approached-as-having-node-negative-disease
#3
Yue Liang, Xiaosong Chen, Weiwei Zhan, David H Garfield, Jiayi Wu, Ou Huang, Yafen Li, Li Zhu, Weiguo Chen, Kunwei Shen
BACKGROUND: Few data exist to elucidate whether patients with a suspicious axillary lymph node (ALN) at ultrasound but a negative fine-needle aspiration result (FNA group) can be managed as having ultrasound node-negative disease (AUN group). This study compared various ALN statuses between the AUN and FNA groups to guide further ALN management. METHODS: Patients who had clinical T1-2N0 breast cancer treated with sentinel lymph node (SLN) biopsy were retrospectively analyzed...
February 6, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28145149/axillary-skip-metastases-and-the-false-negative-rate-of-sentinel-lymph-node-biopsy-in-patients-with-breast-cancer-are-related-to-negative-aldh-1-expression-and-ki-67-expression
#4
Woo Gyeong Kim, JungSun Lee
Breast cancer stem cells (CSCs) have been hypothesized to be the driving force behind tumorigenesis and metastasis. In this study, we evaluated the relationships between CSC expressions in primary breast cancers and corresponding metastatic sentinel and nonsentinel lymph nodes (SLNs and NSLNs). The clinical implications of these relationships were also investigated. CSC expressions were evaluated in 167 breast cancer specimens and associated lymph node biopsies (when present). We used double immunohistochemistry of CD44/CD24 and single immunohistochemistry of ALDH-1 on paraffin-embedded breast tissue, SLN, and NSLN specimens...
January 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28139362/eight-year-follow-up-result-of-the-otoasor-trial-the-optimal-treatment-of-the-axilla-surgery-or-radiotherapy-after-positive-sentinel-lymph-node-biopsy-in-early-stage-breast-cancer-a-randomized-single-centre-phase-iii-non-inferiority-trial
#5
Á Sávolt, G Péley, C Polgár, N Udvarhelyi, G Rubovszky, E Kovács, B Győrffy, M Kásler, Z Mátrai
INTRODUCTION: The National Institute of Oncology, Budapest conducted a single centre randomized clinical study. The OTOASOR (Optimal Treatment Of the Axilla - Surgery Or Radiotherapy) trial compares completion of axillary lymph node dissection (cALND) to regional nodal irradiation (RNI) in patients with sentinel lymph node metastasis (pN1sn) in stage I-II breast cancer. PATIENTS AND METHODS: Patients with primary invasive breast cancer (cN0 and cT ≤ 3 cm) were randomized before surgery for cALND (standard treatment) or RNI (investigational treatment)...
January 16, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28139361/is-intraoperative-touch-imprint-cytology-indicated-in-the-surgical-treatment-of-early-breast-cancers
#6
Z Horváth, A Paszt, Z Simonka, M Látos, V Oláh, D Nagyszegi, L Kaizer, Z Fejes, S Hamar, E Csörgő, K Ormándi, M Lázár, G Lázár
INTRODUCTION: Intraoperative touch imprint cytology (TIC) of the sentinel lymph node(s) (SLN(s)) in the treatment of breast cancer has significantly reduced the number of axillary block dissections (ABD) required during second surgeries. Based on recent studies, ABD was not considered necessary if the presence of tumor cells/micrometastasis was confirmed in the SLN(s) or in the case of macrometastases in a patient group meeting the inclusion criteria for the ACOSOG Z0011 study. Our aim was to determine the sensitivity and usefulness of TIC with regard to these results...
January 18, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28133206/-difficult-decision-about-a-surgical-margin-for-a-non-invasive-apocrine-carcinoma-in-the-breast-report-of-a-case
#7
Tomohiro Hirano, Kenichi Sakurai, Shigeru Fujisaki, Keita Adachi, Shuhei Suzuki, Yuki Masuo, Saki Nagashima, Yukiko Hara, Katsuhisa Enomoto, Ryouichi Tomita, Kenji Gonda
We report a case of non-invasive apocrine carcinoma. In this case, we could not identifythe surgical margin. The patient was 39-year-old woman. Micro calcifications were discovered on her right breast during breast cancer screening. Stereotactic vacuum assisted core needle biopsywas performed and the pathological diagnosis was sclerosing adenosis. A low echoic lesion, 26mm in diameter, was discovered in the CDE area of her left breast byultrasonography . A contrast enhanced MRI showed a high intensityarea, 26mm in diameter, on her left breast...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133052/-intra-cystic-mucinous-carcinoma-of-the-breast-a-case-report
#8
Keita Adachi, Shuhei Suzuki, Yuki Masuo, Saki Nagashima, Yukiko Hara, Tomohiro Hirano, Katsuhisa Enomoto, Kenichi Sakurai, Makoto Makishima, Tsugumichi Koshinaga
A 75-year-old woman consulted our hospital for a lump on her left breast. The tumor was 5 cm in diameter and was palpable in the ABE area. The tumor was identified as an intra-cystic tumor using ultrasonography. Contrast-enhanced magnetic resonance imaging showed a tumor with cystic components that were slowly stained in a dynamic study. A fine needle aspiration biopsywas performed, and the pathological diagnosis was class V. Metastatic work-up revealed no evidence of metastasis. Therefore, we determined the clinical stage as T3N0M0, stage II B...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28052310/ten-year-report-on-axillary-recurrence-after-negative-sentinel-node-biopsy-for-breast-cancer-from-the-swedish-multicentre-cohort-study
#9
J de Boniface, J Frisell, L Bergkvist, Y Andersson
BACKGROUND: The omission of axillary lymph node dissection (ALND) in patients with breast cancer with a negative finding on sentinel node biopsy (SNB) has reduced arm morbidity substantially. Early follow-up reports have shown the rate of axillary recurrence to be significantly lower than expected, with a median false-negative rate of 7 per cent for SNB. Long-term follow-up is needed as recurrences may develop late. METHODS: The Swedish Multicentre Cohort Study included 3518 women with breast cancer and a clinically negative axilla, in whom SNB was planned...
February 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28052186/axillary-treatment-for-operable-primary-breast-cancer
#10
REVIEW
Nathan Bromham, Mia Schmidt-Hansen, Margaret Astin, Elise Hasler, Malcolm W Reed
BACKGROUND: Axillary surgery is an established part of the management of primary breast cancer. It provides staging information to guide adjuvant therapy and potentially local control of axillary disease. Several alternative approaches to axillary surgery are available, most of which aim to spare a proportion of women the morbidity of complete axillary dissection. OBJECTIVES: To assess the benefits and harms of alternative approaches to axillary surgery (including omitting such surgery altogether) in terms of overall survival; local, regional and distant recurrences; and adverse events...
January 4, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28042324/mapping-sentinel-lymph-node-metastasis-by-dual-probe-optical-imaging
#11
Xiangyu Yang, Zhe Wang, Fuwu Zhang, Guizhi Zhu, Jibin Song, Gao-Jun Teng, Gang Niu, Xiaoyuan Chen
Purpose: Sentinel lymph node biopsy (SLNB) has emerged as the preferred standard procedure in patients with breast cancer, melanoma and other types of cancer. Herein, we developed a method to intra-operatively map SLNs and differentiate tumor metastases within SLNs at the same time, with the aim to provide more accurate and real-time intraoperative guidance. Experimental Design: Hyaluronic acid (HA), a ligand of lymphatic vessel endothelial hyaluronan receptor (LYVE)-1, is employed as a SLN mapping agent after being conjugated with a near-infrared fluorophore (Cy5...
2017: Theranostics
https://www.readbyqxmd.com/read/28039730/erratum-factors-predicting-non-sentinel-lymph-node-metastasis-in-t1-2-invasive-breast-cancer-with-1-2-axillary-sentinel-lymph-node-metastases-presentation-of-ondokuz-mayis-scoring-system
#12
Bekir Kuru, Yurdanur Sullu, Savas Yuruker, Ilkay Koray Bayrak, Necati Ozen
In this article published in Volume 21, issue 5, the Results section of the Pubmed abstract appeared as: "There were 68 (33%) and 108 (52%) patients with a the score of ? 4 (predicted probability of ?10%) with a false negative rate (FNR% of 4.4%, and ?5 (predicted probability of ?15%) with a FNR of 7.4%, respectively. The area under the curve (AUC) value for the Ondokuz Mayis scoring system was 0.88 (95% CI 0.83-0.93%)." The correct Results section of the abstract is: "There were 68 (33%) and 108 (52%) patients with a the score of ≤4 (predicted probability of ≤10%) with a false negative rate (FNR) of 4...
November 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28030783/total-tumor-load-assessed-by-one-step-nucleic-acid-amplification-assay-as-an-intraoperative-predictor-for-non-sentinel-lymph-node-metastasis-in-breast-cancer
#13
Celso Nabais, Joana Figueiredo, Paulina Lopes, Manuela Martins, António Araújo
BACKGROUND: This study aimed to determine the relationship between CK19 mRNA copy number in sentinel lymph nodes (SLN) assessed by one-step nucleic acid amplification (OSNA) technique, and non-sentinel lymph nodes (NSLN) metastization in invasive breast cancer. A model using total tumor load (TTL) obtained by OSNA technique was also constructed to evaluate its predictability. METHODS: We conducted an observational retrospective study including 598 patients with clinically T1-T3 and node negative invasive breast cancer...
April 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28009075/assessment-of-sentinel-lymph-node-metastasis-in-canine-mammary-gland-tumors-using-computed-tomographic-indirect-lymphography
#14
Christina Soultani, Michail N Patsikas, Maria Karayannopoulou, Samuel Jakovljevic, Ioannis Chryssogonidis, Lysimachos Papazoglou, Nikolaos Papaioannou, Paraskevi Papadopoulou, Kyriaki Pavlidou, Georgia M Ilia, Dimitrios G Kaitzis, Tatiana M Ilia
In the staging process of the breast cancer, demonstrating metastasis of the sentinel lymph node (SLN) has an important prognostic value, in both humans and animals. The aim of this prospective case-control study was to determine the diagnostic value of computed tomographic indirect lymphography (CT-LG) for detecting SLN metastasis in dogs with mammary cancer. Thirty-three female dogs with tumors in the abdominal and inguinal mammary glands were prospectively selected and subjected to CT-LG, 1 and 5 min after injection of 1 ml of contrast agent (iopamidol) in the subareolar tissue of the neoplastic and the contralateral normal mammary glands...
March 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/27872527/role-of-axillary-ultrasound-fine-needle-aspiration-cytology-and-sentinel-lymph-node-biopsy-in-clinically-n0-breast-cancer
#15
Gaurav Goel, P D Janaki, N V Smitha, Rajanbabu Anupama, P Shanmugha Sundaram, Y S Nataraj, D K Vijaykumar
This study evaluates the combined role of axillary ultrasound, fine needle aspiration cytology and sentinel lymph node biopsy in clinically N0 axilla. Between January 2014 and June 2015, 150 women with early breast cancer underwent axillary ultrasound as a first investigation for nodal status. Suspicious nodes were subjected to image guided fine needle aspiration cytology. Non-suspicious and fine needle aspiration cytology negative axillary nodes proceeded to sentinel lymph node biopsy at time of primary breast surgery...
December 2016: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27856201/daily-practice-management-of-pt1a-b-pn0-breast-carcinoma-a-prospective-french-odissee-cohort-study
#16
Florence Dalenc, Frédérique Penault-Llorca, Monique Cohen, Gilles Houvenaeghel, Jean-Marc Piat, Philippe Liegeois, Laurent Puyuelo, Jean-Philippe Suchaud, Mohammed Zouai, Magali Lacroix-Triki, Nina Radosevic-Robin, Chahinez Benkanoun, Hanane Attar-Rabia, Marie-Pierre Chauvet, Joseph Gligorov, Yazid Belkacemi
BACKGROUND: Most breast cancer (BC) tumors ≤10 mm have an excellent prognosis. The subgroups with a higher risk for distant recurrence requiring adjuvant systemic therapy are not precisely defined in current international guidelines. PATIENTS AND METHODS: The OBSERVATOIRE DES PETITS CANCERS DU SEIN HER2 +/- (ODISSEE) study was a prospective, multicenter, cohort study that aimed to describe the daily adjuvant management and outcome of 616 patients with unifocal, invasive pT1a-b pN0 nonmetastatic BC who underwent surgery...
August 31, 2016: Clinical Breast Cancer
https://www.readbyqxmd.com/read/27852049/a-nomogram-to-predict-the-probability-of-axillary-lymph-node-metastasis-in-female-patients-with-breast-cancer-in-china-a-nationwide-multicenter-10-year-epidemiological-study
#17
Jian Zhang, Xiao Li, Rong Huang, Wei-Liang Feng, Ya-Nan Kong, Feng Xu, Lin Zhao, Qing-Kun Song, Jing Li, Bao-Ning Zhang, Jin-Hu Fan, You-Lin Qiao, Xiao-Ming Xie, Shan Zheng, Jian-Jun He, Ke Wang
Axillary lymph node dissection (ALND) or sentinel lymph node biopsy (SLNB) alone may lead to postoperative complications. Among patients with positive ALN in the preoperative examination, approximately 40% patients do not have SLN metastasis. Herein, we aimed to develop a model to predict the probability of ALN metastasis as a preoperative tool to support clinical decision-making. We retrospectively analyzed the clinicopathological features of 4211 female patients with breast cancer who were diagnosed in seven breast cancer centers representing entire China, over 10 years (1999-2008)...
November 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27810698/intraoperative-assessment-of-sentinel-lymph-node-by-one-step-nucleic-acid-amplification-in-breast-cancer-patients-after-neoadjuvant-treatment-reduces-the-need-for-a-second-surgery-for-axillary-lymph-node-dissection
#18
COMPARATIVE STUDY
Martin Espinosa-Bravo, Joaquin Navarro-Cecilia, Manuel Ramos Boyero, Sebastian Diaz-Botero, Basilio Dueñas Rodríguez, Carolina Luque López, Teresa Ramos Grande, Ricardo Ruano Perez, Vicente Peg, Isabel T Rubio
PURPOSE: Sentinel lymph node (SLN) biopsy has been shown to be both accurate and feasible for women who receive neoadjuvant chemotherapy (NAC). Intraoperative assessment of SLN by frozen sections can produce false negative results. The aim of this study was to compare two different techniques of intraoperative assessment of SLN in breast cancer patients treated with NAC: frozen section (FS) and molecular assay (OSNA). METHODS: A multicenter cohort of 320 consecutive breast cancer patients treated with NAC between 2010 and 2014 was analyzed...
February 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27802189/a-case-of-multicentric-low-grade-neuroendocrine-breast-tumor-with-an-unusual-histological-pattern
#19
Antonio D'Antonio, Maria Addesso, Domenico Memoli, Annamaria Cascone, Luigi Cremone
Neuroendocrine features are detectable in carcinomas of the breast either as scattered cells, that are recognized by their expression of neuroendocrine cell markers. Instead, pure breast carcinomas with neuroendocrine features (NEBC) are very rare and represent <1% of all breast cancer. Usually NEBC may be well or poorly differentiated and more frequent in older woman. These tumors showed variable histological pattern but a common feature is represented by expression of neuroendocrine markers. Here we report a case of a primary multicentric low-grade neuroendocrine carcinoma of the breast presented because of its rarity and for the unusual tubular and cribriform pattern resembling a well-differentiated conventional breast carcinoma...
2016: Breast Disease
https://www.readbyqxmd.com/read/27756234/sentinel-lymph-node-biopsy-after-neoadjuvant-chemotherapy-for-breast-cancer-retrospective-comparative-evaluation-of-clinically-axillary-lymph-node-positive-and-negative-patients-including-those-with-axillary-lymph-node-metastases-confirmed-by-fine-needle-aspiration
#20
Yue Yu, Ning Cui, Heng-Yu Li, Yan-Mei Wu, Lu Xu, Min Fang, Yuan Sheng
BACKGROUND: To evaluate the accuracy of sentinel lymph node biopsy (SLNB) after neoadjuvant chemotherapy (NAC) in breast cancer patients with axillary lymph node (ALN) metastasis. METHODS: A total of 122 patients with operable breast cancer were enrolled in this single-center retrospective study. Eighty patients were clinically diagnosed with a positive axillary lymph node (ALN) via imaging or physical examination (including 66 patients with biopsy-proven metastasis)...
October 18, 2016: BMC Cancer
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