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Breast sentinel lymph node metastasis

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https://www.readbyqxmd.com/read/27872527/role-of-axillary-ultrasound-fine-needle-aspiration-cytology-and-sentinel-lymph-node-biopsy-in-clinically-n0-breast-cancer
#1
Gaurav Goel, P D Janaki, N V Smitha, Rajanbabu Anupama, P Shanmugha Sundaram, Y S Nataraj, D K Vijaykumar
This study evaluates the combined role of axillary ultrasound, fine needle aspiration cytology and sentinel lymph node biopsy in clinically N0 axilla. Between January 2014 and June 2015, 150 women with early breast cancer underwent axillary ultrasound as a first investigation for nodal status. Suspicious nodes were subjected to image guided fine needle aspiration cytology. Non-suspicious and fine needle aspiration cytology negative axillary nodes proceeded to sentinel lymph node biopsy at time of primary breast surgery...
December 2016: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27856201/daily-practice-management-of-pt1a-b-pn0-breast-carcinoma-a-prospective-french-odissee-cohort-study
#2
Florence Dalenc, Frédérique Penault-Llorca, Monique Cohen, Gilles Houvenaeghel, Jean-Marc Piat, Philippe Liegeois, Laurent Puyuelo, Jean-Philippe Suchaud, Mohammed Zouai, Magali Lacroix-Triki, Nina Radosevic-Robin, Chahinez Benkanoun, Hanane Attar-Rabia, Marie-Pierre Chauvet, Joseph Gligorov, Yazid Belkacemi
BACKGROUND: Most breast cancer (BC) tumors ≤10 mm have an excellent prognosis. The subgroups with a higher risk for distant recurrence requiring adjuvant systemic therapy are not precisely defined in current international guidelines. PATIENTS AND METHODS: The OBSERVATOIRE DES PETITS CANCERS DU SEIN HER2 +/- (ODISSEE) study was a prospective, multicenter, cohort study that aimed to describe the daily adjuvant management and outcome of 616 patients with unifocal, invasive pT1a-b pN0 nonmetastatic BC who underwent surgery...
August 31, 2016: Clinical Breast Cancer
https://www.readbyqxmd.com/read/27852049/a-nomogram-to-predict-the-probability-of-axillary-lymph-node-metastasis-in-female-patients-with-breast-cancer-in-china-a-nationwide-multicenter-10-year-epidemiological-study
#3
Jian Zhang, Xiao Li, Rong Huang, Wei-Liang Feng, Ya-Nan Kong, Feng Xu, Lin Zhao, Qing-Kun Song, Jing Li, Bao-Ning Zhang, Jin-Hu Fan, You-Lin Qiao, Xiao-Ming Xie, Shan Zheng, Jian-Jun He, Ke Wang
Axillary lymph node dissection (ALND) or sentinel lymph node biopsy (SLNB) alone may lead to postoperative complications. Among patients with positive ALN in the preoperative examination, approximately 40% patients do not have SLN metastasis. Herein, we aimed to develop a model to predict the probability of ALN metastasis as a preoperative tool to support clinical decision-making. We retrospectively analyzed the clinicopathological features of 4211 female patients with breast cancer who were diagnosed in seven breast cancer centers representing entire China, over 10 years (1999-2008)...
November 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27810698/intraoperative-assessment-of-sentinel-lymph-node-by-one-step-nucleic-acid-amplification-in-breast-cancer-patients-after-neoadjuvant-treatment-reduces-the-need-for-a-second-surgery-for-axillary-lymph-node-dissection
#4
Martin Espinosa-Bravo, Joaquin Navarro-Cecilia, Manuel Ramos Boyero, Sebastian Diaz-Botero, Basilio Dueñas Rodríguez, Carolina Luque López, Teresa Ramos Grande, Ricardo Ruano Perez, Vicente Peg, Isabel T Rubio
PURPOSE: Sentinel lymph node (SLN) biopsy has been shown to be both accurate and feasible for women who receive neoadjuvant chemotherapy (NAC). Intraoperative assessment of SLN by frozen sections can produce false negative results. The aim of this study was to compare two different techniques of intraoperative assessment of SLN in breast cancer patients treated with NAC: frozen section (FS) and molecular assay (OSNA). METHODS: A multicenter cohort of 320 consecutive breast cancer patients treated with NAC between 2010 and 2014 was analyzed...
October 28, 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27802189/a-case-of-multicentric-low-grade-neuroendocrine-breast-tumor-with-an-unusual-histological-pattern
#5
Antonio D'Antonio, Maria Addesso, Domenico Memoli, Annamaria Cascone, Luigi Cremone
Neuroendocrine features are detectable in carcinomas of the breast either as scattered cells, that are recognized by their expression of neuroendocrine cell markers. Instead, pure breast carcinomas with neuroendocrine features (NEBC) are very rare and represent <1% of all breast cancer. Usually NEBC may be well or poorly differentiated and more frequent in older woman. These tumors showed variable histological pattern but a common feature is represented by expression of neuroendocrine markers. Here we report a case of a primary multicentric low-grade neuroendocrine carcinoma of the breast presented because of its rarity and for the unusual tubular and cribriform pattern resembling a well-differentiated conventional breast carcinoma...
October 14, 2016: Breast Disease
https://www.readbyqxmd.com/read/27756234/sentinel-lymph-node-biopsy-after-neoadjuvant-chemotherapy-for-breast-cancer-retrospective-comparative-evaluation-of-clinically-axillary-lymph-node-positive-and-negative-patients-including-those-with-axillary-lymph-node-metastases-confirmed-by-fine-needle-aspiration
#6
Yue Yu, Ning Cui, Heng-Yu Li, Yan-Mei Wu, Lu Xu, Min Fang, Yuan Sheng
BACKGROUND: To evaluate the accuracy of sentinel lymph node biopsy (SLNB) after neoadjuvant chemotherapy (NAC) in breast cancer patients with axillary lymph node (ALN) metastasis. METHODS: A total of 122 patients with operable breast cancer were enrolled in this single-center retrospective study. Eighty patients were clinically diagnosed with a positive axillary lymph node (ALN) via imaging or physical examination (including 66 patients with biopsy-proven metastasis)...
October 18, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27738336/axillary-and-internal-mammary-sentinel-lymph-node-biopsy-in-breast-cancer-after-neoadjuvant-chemotherapy
#7
Xiao-Shan Cao, Hui-Juan Li, Bin-Bin Cong, Xiao Sun, Peng-Fei Qiu, Yan-Bing Liu, Chun-Jian Wang, Yong-Sheng Wang
With the improvement of neoadjuvant chemotherapy (NAC), the proportion of pathological complete response (pCR) in the breast and axillary lymph node (ALN) is increasing. The evaluation of pCR does not include the status of internal mammary lymph node (IMLN). This study is to evaluate the roles of both axillary sentinel lymph node biopsy (ASLNB) and internal mammary sentinel lymph node biopsy (IM-SLNB) in breast cancer patients after NAC. There were 74 patients enrolled into this study. IM-SLNB was performed on patients with radioactive internal mammary sentinel lymph node (IM-SLN)...
October 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27726422/radiologic-mapping-for-targeted-axillary-dissection-needle-biopsy-to-excision
#8
Kyungmin Shin, Abigail S Caudle, Henry M Kuerer, Lumarie Santiago, Rosalind P Candelaria, Basak Dogan, Jessica Leung, Savitri Krishnamurthy, Wei Yang
OBJECTIVE: The purpose of this article is to describe the feasibility and safety of a multidisciplinary approach to imaging-guided axillary staging that facilitates personalized, less invasive surgical management of the axilla through targeted axillary dissection in patients with biopsy-proven nodal metastasis undergoing neoadjuvant chemotherapy. CONCLUSION: Axillary nodal status, critical in breast cancer staging, affects prognosis and treatment. As the paradigm shifts toward minimally invasive therapy, a clip marker is placed in the biopsied metastatic node for patients with N1-N2 disease undergoing neoadjuvant chemotherapy to facilitate targeted axillary dissection of the clipped node...
December 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27721714/breast-cancer-sentinel-node-detection-an-alternative-solution-for-centers-lacking-nuclear-technology
#9
Mahmoud A Alhussini, Ahmed T Awad, Mohamed H Ashour, Ahmed Abdelateef, Haytham Fayed
BACKGROUND: Sentinel lymph node (SLN) has become the gold standard for all cases with no axillary nodal metastasis. The combined radioisotope and blue dye technique is adopted in most centers. The lack of the technology for radioisotope in our institution encouraged us to study the feasibility of methylene blue (MB) for SLN detection in breast cancer patients admitted to Alexandria Surgical Oncology Unit. METHODS: A total of 144 cases were subjected to SLN detection by injecting 2 ml of MB 1%...
August 2016: Breast Care
https://www.readbyqxmd.com/read/27692774/can-sentinel-lymph-node-biopsy-be-spared-in-papillary-carcinoma-of-the-breast
#10
Yihong Wang, Shaolei Lu, Theresa Graves, Madhu M Ouseph, Murray B Resnick, Evgeny Yakirevich
BACKGROUND: Papillary carcinoma (PC) of the breast represents ∼0.5% of all newly diagnosed cases of breast cancer and usually has an indolent course. The current data suggest lack of a consensus in the surgical management of this disease. Because patients can occasionally develop metastatic disease, sentinel lymph node (SLN) biopsy is often performed during surgery. MATERIALS AND METHODS: In the present study, we retrospectively evaluated the histologic characteristics of 99 cases of PC with or without associated frank invasive carcinoma, including 43 encapsulated or intracystic PCs, 24 solid PCs, and 32 intraductal PCs, and correlated these with the incidence of nodal metastasis...
September 8, 2016: Clinical Breast Cancer
https://www.readbyqxmd.com/read/27668857/the-significance-of-sentinel-lymph-node-micrometastasis-in-breast-cancer-comparing-outcomes-with-and-without-axillary-clearance
#11
Mina M G Youssef, Diane Cameron, Philip H Pucher, Sisse Olsen, Douglas Ferguson
BACKGROUND: Management of micrometastasis in the sentinel node is a controversial topic. Most of the guidelines don't recommend further axillary treatment if micrometastasis are the only finding in the sentinel node. However, some evidence suggests that micrometastasis have significant effect on long term outcomes and therefore indicate systemic treatment. METHOD: Retrospective cohort study reviewing the management of patients with micrometastasis in the sentinel nodes...
December 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27666747/availability-of-sentinel-lymph-node-biopsy-for-cutaneous-squamous-cell-carcinoma
#12
Hiroshi Maruyama, Ryota Tanaka, Yasuhiro Fujisawa, Yasuhiro Nakamura, Shusaku Ito, Manabu Fujimoto
Cutaneous squamous cell carcinoma is the second common cutaneous cancer, especially in the elderly. Sentinel lymph node biopsy is generally performed in breast cancers and cutaneous melanomas to detect occult nodal metastases. The benefit of sentinel lymph node biopsy in improving cutaneous squamous cell carcinoma prognosis is doubtful. One hundred and sixty-nine patients who underwent treatment for cutaneous squamous cell carcinoma between 2004 and 2015, and who were followed up for at least 6 months or developed metastases within the follow-up period were included...
September 26, 2016: Journal of Dermatology
https://www.readbyqxmd.com/read/27633450/application-of-a-predictive-model-of-axillary-lymph-node-status-in-patients-with-sentinel-node-metastasis-from-breast-cancer-a%C3%A2-retrospective-cohort-study
#13
Salvatore Vieni, Giuseppa Graceffa, Roberta La Mendola, Stefania Latteri, Adriana Cordova, Mario Adelfio Latteri, Calogero Cipolla
BACKGROUND AND OBJECTIVES: The Axillary Lymph Node Dissection (ALND) is the standard treatment in patients with invasive breast cancer and sentinel node metastasis, but in 60% of the cases there is no further axillary neoplastic involvement, so this invasive intervention represents an overtreatment. The purpose of the study is to identify patients with low risk of additional nodal metastases, to omit ALND. METHODS: The MSKCC Additional nodal metastasis nomogram was applied on a sample of 175 patients with invasive breast cancer who underwent ALND after detection of macrometastasis with the extemporaneous examination of the sentinel lymph node...
September 12, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27591153/prediction-of-nonsentinel-lymph-node-metastasis-in-breast-cancer-patients-with-one-or-two-positive-sentinel-lymph-nodes
#14
Bahadır Öz, Alper Akcan, Serap Doğan, Ümmühan Abdulrezzak, Dicle Aslan, Erdoğan Sözüer, Ertan Emek, Muhammet Akyüz, Ferhan Elmalı, Engin Ok
OBJECTIVE: The aim of the present study was to investigate the association between non sentinel lymph node metastasis (NSLNM) and clinicopathological factors, particularly in the case of sentinel lymph node (SLN) metastasis in one or two, in clinically node negative patients with breast cancer. METHODS: Between 10/2010 and 10/2014, 350 sentinel lymph node biopsy (SLNB) were performed in patients with histologically proven primary breast cancer in our clinic. The data collection includes the following characteristics: age, pathological tumor size, histological type, histological grade, lymphovascular invasion (LVI), number of positive SLN, size of the SLN metastasis (macrometastasis, micrometastasis, isolated tumor cells), multifocality (MF), extracapsuler invasion (ECI) of the SLN, the estrogen receptor (ER) status, the progesterone receptor (PR) status and the Her 2 receptor status, Ki 67 reseptor status...
August 30, 2016: Asian Journal of Surgery
https://www.readbyqxmd.com/read/27576704/a-nomogram-for-predicting-the-pathological-response-of-axillary-lymph-node-metastasis-in-breast-cancer-patients
#15
Xi Jin, Yi-Zhou Jiang, Sheng Chen, Zhi-Ming Shao, Gen-Hong Di
The value of sentinel lymph node biopsy (SLNB) in post-neoadjuvant chemotherapy (NCT) patients is still controversial. We aimed to identify predictors and construct a nomogram for predicting the pathologically complete response (pCR) of axillary lymph nodes (ALNs) after NCT in node positive breast cancer patients. In total, 426 patients with pathologically proven ALN metastasis before NCT were enrolled, randomized 1:1 and divided into a training set and a validation set. We developed a nomogram based on independent predictors for ALN pCR identified by multivariate logistic regression as well as clinical significant predictors...
August 31, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27566039/the-predictive-value-of-increased-sentinel-lymph-node-volume-in-breast-cancer
#16
B A Krasnick, S D Nathanson, C N Arbabi, D A Chitale, E L Peterson
BACKGROUND: Breast cancer sentinel lymph nodes (SLNs) with metastases (mets) are often palpably enlarged. We hypothesized that the volume of the SLN and the size of mets are directly related. SLNs harboring mets are often firm, with increased intra-nodal pressure (INP), and we hypothesized that SLN volume, as well as INP, would correlate directly with SLN metastasis size. METHODS: The SLN volume, INP and met size were measured in 296 SLNs and compared using linear regression analysis...
September 2016: Surgical Oncology
https://www.readbyqxmd.com/read/27562691/recommendation-for-axillary-lymph-node-dissection-in-women-with-early-breast-cancer-and-sentinel-node-metastasis-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials-using-the-grade-system
#17
Tsai-Wei Huang, Ken N Kuo, Kee-Hsin Chen, Chiehfeng Chen, Wen-Hsuan Hou, Wei-Hwa Lee, Tsu-Yi Chao, Jo-Ting Tsai, Chih-Ming Su, Ming-Te Huang, Ka-Wai Tam
BACKGROUND: In 2014, the American Society of Clinical Oncology published an updated clinical practice guideline on axillary lymph node dissection (ALND) for early-stage breast cancer patients. However, these recommendations have been challenged because they were based on data from only one randomized controlled trial (RCT). We evaluated the rationale of these recommendations by systematically reviewing RCTs using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) system...
August 22, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27557827/axillary-ultrasound-for-all-for-none-to-diagnose-positive-nodes-or-to-support-avoiding-sentinel-lymph-node-biopsy-altogether
#18
Dalliah Black
Axillary ultrasound is increasingly utilized for nodal staging preoperatively in patients presenting with invasive breast cancer to provide guidance for preoperative chemotherapy or proceeding directly to surgery. Improvements in ultrasound technology make it possible to assess the nodal burden in order to identify those patients not eligible for ACOSOG Z0011 management. However, its ability to detect metastasis is variable and dependent on operator's skills, size of metastatic deposit, and primary tumor histology subtype...
August 24, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27549784/one-step-nucleic-acid-amplification-osna-where-do-we-go-with-it
#19
Yasuhiro Tamaki
The one-step nucleic acid amplification (OSNA) assay was initially developed for the intraoperative assessment of sentinel lymph node metastases in breast cancer. This assay measures cytokeratin 19 (CK19) mRNA copy number and is widely used in hospitals. The results of the IBCSG 23-01, ACOSOG Z0011, and AMAROS trials demonstrated that no further axillary dissection is required for patients with sentinel lymph nodes that tested positive for cancer, which has led to a decreasing trend in the need for intraoperative assessment of lymph nodes...
August 22, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27546694/factors-affecting-sentinel-lymph-node-metastasis-in-turkish-breast-cancer-patients-predictive-value-of-ki-67-and-the-size-of-lymph-node
#20
I A Ozemir, K Orhun, T Eren, H Baysal, J Sagiroglu, M Leblebici, A B Ceyran, O Alimoglu
OBJECTIVES: We aimed to analyze the factors that affect the axillary lymph node involvement in Turkish breast cancer patients with clinically non-palpable axillary lymph node. BACKGROUND: Sentinel lymph node biopsy is the gold standard technique to evaluate the axillary lymph node status that directly influences the prognosis and the treatment options in breast cancer. METHODS: Breast cancer patients without axillary lymph node involvement in clinic examination were enrolled the study...
2016: Bratislavské Lekárske Listy
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