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https://www.readbyqxmd.com/read/28421498/chapter-14-establishing-an-oocyte-cryobank-network
#1
James Graham, Josh Lim, Michael Tucker
Improvements in oocyte cryopreservation has prompted wider acceptance of this technology leading to its use for several reasons. Notably, in addition to elective and medically driven reasons for oocyte cryostorage for fertility preservation, donor oocyte cryobanking is beginning to gain traction, potentially replacing fresh oocyte donation in assisted reproduction. Donor "egg banking," while not totally analogous to donor sperm banking, does provide strong benefits in terms of scheduling flexibility and improved clinical efficiencies, while providing a wider immediate inventory choice...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28333245/euploidy-rates-in-donor-egg-cycles-significantly-differ-between-fertility-centers
#2
S Munné, M Alikani, L Ribustello, P Colls, Pedro A Martínez-Ortiz, D H McCulloh
STUDY QUESTION: Do external factors affect euploidy in egg donor cycles? SUMMARY ANSWER: The study demonstrates that during human assisted reproduction, embryonic chromosome abnormalities may be partly iatrogenic. WHAT IS KNOWN ALREADY: Chromosome abnormalities have been linked in the past to culture conditions such as temperature and Ph variations, as well as hormonal stimulation. Those reports were performed with older screening techniques (FISH), or ART methods no longer in use, and the subjects studied were not a homogeneous group...
April 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28324453/analysis-of-the-main-risk-factors-for-gestational-diabetes-diagnosed-with-international-association-of-diabetes-and-pregnancy-study-groups-iadpsg-criteria-in-multiple-pregnancies
#3
M Cozzolino, C Serena, L Maggio, M P Rambaldi, S Simeone, G Mello, L Pasquini, M Di Tommaso, F Mecacci
INTRODUCTION: The aim is to investigate the proportion of multiple pregnancies with gestational diabetes mellitus (GDM) diagnosed using the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria and to identify the impact of age, body mass index (BMI), and mode of conception on incidence of GDM. MATERIALS AND METHODS: This is a single center, retrospective cohort study on 656 multiple pregnancies screened for GDM with 75-g, 2-h oral glucose tolerance test at 24-28 weeks of gestation, between January 2010 and January 2016...
March 21, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28292612/perinatal-outcomes-in-children-born-after-fresh-or-frozen-embryo-transfer-a-catalan-cohort-study-based-on-14-262-newborns
#4
Mar Vidal, Kilian Vellvé, Mireia González-Comadran, Ana Robles, Maria Prat, Mar Torné, Ramón Carreras, Miguel A Checa
OBJECTIVE: To ascertain whether perinatal outcomes are affected by vitrification and/or controlled ovarian hyperstimulation (COH). DESIGN: Register-based cohort study. SETTING: Not applicable. PATIENT(S): Women undergoing in vitro fertilization (IVF) between 2008 and 2012 using autologous or donated eggs who had a singleton pregnancy delivered from the 24th week onward. INTERVENTION(S): Fresh embryo transfer (ET) or frozen-thawed ET in women undergoing IVF...
April 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28285954/anti-m%C3%A3-llerian-hormone-concentrations-and-parity-in-fertile-women-the-model-of-oocyte-donors
#5
Sophie Catteau-Jonard, Marie Roux, Agathe Dumont, Anne-Sophie Delesalle, Geoffroy Robin, Didier Dewailly
In France until the end of 2015, oocyte donors must have had at least one child and be aged 18-37 years. This population of fertile women was selected to examine whether serum anti-Müllerian hormone (AMH) concentration could be a reliable correlate of spontaneous pregnancy in women who had proven their fertility before. A cohort of 217 women followed between 2009 and 2015 for oocyte donation at the University Hospital of Lille comprised this retrospective study. In these egg donors, aged 20-37 (median: 32 years), the median serum AMH level was 22 pmol/l (5-95th percentiles: 4...
March 1, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28260557/the-influence-of-in-vitro-fertilization-and-embryo-culture-on-the-embryo-epigenetic-constituents-and-the-possible-consequences-in-the-bovine-model
#6
M-A Sirard
Medically assisted reproductive technologies, such as in vitro embryo production, are increasingly being used to palliate infertility. Eggs are produced following a hormonal regimen that stimulates the ovaries to produce a large number of oocytes. Collected oocytes are then fertilized in vitro and allowed to develop in vitro until they are either frozen or transferred to mothers. There are controversial reports on the adverse impacts of these technologies on early embryos and their potential long-term effects...
March 6, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28186956/uterine-artery-doppler-pulsatility-index-at-11-38-weeks-in-icsi-pregnancies-with-egg-donation
#7
Annalisa Inversetti, Luca Mandia, Massimo Candiani, Irene Cetin, Alessandro Larcher, Valeria Savasi, Enrico Papaleo, Paolo Cavoretto
BACKGROUND: Uterine artery Doppler pulsatility index (UtA-PI) may be different in pregnancies with egg donation (ICSI-ED) as compared to conceptions with autologous intra-cytoplasmatic sperm injection (autologous ICSI) and to spontaneous conceptions (SC). METHODS: One hundred and ninety-four pregnant women with different modes of conception (MC) were prospectively evaluated: 53 ICSI-ED, 36 autologous ICSI and 105 SC. To evaluate the effects of different MC on PI, multivariable linear regression (MLR) models predicting UtA-PI were fitted after adjustment for maternal age, body mass index, race, parity, smoking status and gestational age...
February 10, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28186611/-ethical-issues-of-oocyte-donation
#8
Yanjin Liu, Libai Cai
The birth and development of oocyte donation technology have brought hope for women with poor ovarian reserve and repeated failure for in vitro fertilization, as well as for those with chromosomal abnormalities, premature ovarian failure, or at perimenopausal or menopausal stages. It has not only preserved their reproductive right, but also stabilized their families and increased social harmony. However, this technology does not only involve infertile couples themselves, but also social and ethical issues concerning their families and the society...
February 10, 2017: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/28136000/altruism-or-obligation-the-motivations-and-experience-of-women-who-donate-oocytes-to-known-recipients-in-assisted-conception-treatment-an-interpretative-phenomenological-analysis-study
#9
Santanu Acharya, Louise Bryant, Maureen Twiddy
INTRODUCTION: This qualitative study was conducted to explore the motivations and experience of oocyte donors donating to women known to them. METHODS: Three women who donated oocytes to a close relative were interviewed and data were analysed using an Interpretative Phenomenological Analysis approach. RESULTS: The two key elements noted were "motivations for donation" and "coping with the consequences of oocyte donation". The motivation for donation was influenced by the familial bond that was strengthened by the donation process in some cases...
March 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28094433/bmp15-knockout-like-effect-in-familial-premature-ovarian-insufficiency-with-persistent-ovarian-reserve
#10
A Mayer, B Fouquet, M Pugeat, M Misrahi
Premature ovarian insufficiency (POI) affects 1% to 2% of women under 40 years. Bone morphogenetic protein 15 (BMP15) variants have been described in POI. We studied a family with 2 sisters compound heterozygous for deletions in the BMP15 gene on chromosome Xp11.22 yielding a human "knockout-like" effect: a c.151_152delGA deletion yielded a p.Glu51IlefsTer27 mutation transmitted by the hemizygous father and a c.189_198delAGGGCATTCAinsTG deletion/insertion yielded a p.Glu64AlafsTer12 mutation transmitted by the heterozygous mother...
January 17, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28093649/naturalistic-experimental-designs-as-tools-for-understanding-the-role-of-genes-and-the-environment-in-prevention-research
#11
Leslie D Leve, Jenae M Neiderhiser, Gordon T Harold, Misaki N Natsuaki, Brendan J M Bohannan, William A Cresko
Before genetic approaches were applied in experimental studies with human populations, they were used by animal and plant breeders to observe, and experimentally manipulate, the role of genes and environment on specific phenotypic or behavioral outcomes. For obvious ethical reasons, the same level of experimental control is not possible in human populations. Nonetheless, there are natural experimental designs in human populations that can serve as logical extensions of the rigorous quantitative genetic experimental designs used by animal and plant researchers...
January 16, 2017: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/28005900/diagnostic-tests-to-support-late-stage-control-programs-for-schistosomiasis-and-soil-transmitted-helminthiases
#12
REVIEW
Kenneth R Hawkins, Jason L Cantera, Helen L Storey, Brandon T Leader, Tala de Los Santos
Global efforts to address schistosomiasis and soil-transmitted helminthiases (STH) include deworming programs for school-aged children that are made possible by large-scale drug donations. Decisions on these mass drug administration (MDA) programs currently rely on microscopic examination of clinical specimens to determine the presence of parasite eggs. However, microscopy-based methods are not sensitive to the low-intensity infections that characterize populations that have undergone MDA. Thus, there has been increasing recognition within the schistosomiasis and STH communities of the need for improved diagnostic tools to support late-stage control program decisions, such as when to stop or reduce MDA...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28003869/attitudes-toward-regulations-of-reproductive-care-in-the-european-union-a-comparison-between-travellers-for-cross-border-reproductive-care-and-citizens-of-the-local-country
#13
R Hertz, M K Nelson, J Suñol
This paper compares two populations with respect to attitudes toward the regulation of reproductive care by the European Union. The two populations are 252 individuals who crossed a national border to receive treatment at an independent clinic in Spain and 45 Spanish citizens who received treatment in their home country. Online surveys were sent to former patients (from many different countries) of a private Spanish clinic. By comparing those who engaged in cross-border reproductive care (CBRC) with those who did not, we examined attitudes toward whether or not the EU should extend to all clients in all countries the type of services the clinic provided...
September 2016: Facts, Views & Vision in ObGyn
https://www.readbyqxmd.com/read/27917504/constructing-and-enacting-kinship-in-sister-to-sister-egg-donation-families-a-multi-family-member-interview-study
#14
Hanna Van Parys, Veerle Provoost, Kristin Zeiler, Petra De Sutter, Guido Pennings, Ann Buysse
Although intra-familial egg donation has been practiced for more than 15 years in several countries, little is known about family relationships in this family type. Framed within the new kinship studies, this article focuses on the experiential dimension of kinship in sister-to-sister egg donation families: how is kinship 'unpacked' and 'reconstructed' in this specific family constellation? Qualitative data analysis of interviews with receiving parents, their donating sisters and the donor children revealed six themes: (1) being connected as an extended family; (2) disambiguating motherhood; (3) giving and receiving as structuring processes; (4) acknowledging and managing the 'special' link between donor and child; (5) making sense of the union between father and donor; and (6) kinship constructions being challenged...
December 5, 2016: Sociology of Health & Illness
https://www.readbyqxmd.com/read/27911012/the-role-of-age-of-disclosure-of-biological-origins-in-the-psychological-wellbeing-of-adolescents-conceived-by-reproductive-donation-a-longitudinal-study-from-age-1-to-age-14
#15
Elena Ilioi, Lucy Blake, Vasanti Jadva, Gabriela Roman, Susan Golombok
BACKGROUND: The question of whether children should be told of their biological origins is one of the most controversial issues regarding the birth of children through donated eggs, sperm, embryos or surrogacy. METHODS: In the sixth phase of this longitudinal study when the children were aged 14 years, family relationships and adolescent adjustment were examined in 87 families created through reproductive donation and 54 natural conception families. The quality of family relationships was assessed by standardised interview with mothers and by standardised questionnaires and an observational measure with mothers and adolescents...
March 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/27825378/buying-and-selling-human-eggs-infertility-providers-ethical-and-other-concerns-regarding-egg-donor-agencies
#16
Robert Klitzman
BACKGROUND: Egg donor agencies are increasingly being used as part of IVF in the US, but are essentially unregulated, posing critical ethical and policy questions concerning how providers view and use them, and what the implications might be. METHODS: Thirty-seven in-depth interviews of approximately 1 h were conducted - with 27 IVF providers and 10 patients. RESULTS: Clinicians vary in their views and interactions concerning egg donor agencies, ranging widely in whether and how often they use agencies...
November 8, 2016: BMC Medical Ethics
https://www.readbyqxmd.com/read/27822347/acceptance-and-disclosure-comparing-genetic-symmetry-and-genetic-asymmetry-in-heterosexual-couples-between-egg-recipients-and-embryo-recipients
#17
R Hertz, M K Nelson
This paper explores the attitudes and experiences of 203 women in heterosexual couples who conceived via donated eggs (145) or donated embryos (58) in the last 5 years. Online surveys were sent to former patients (from many different countries) of a private Spanish clinic. By comparing the women in heterosexual couples who relied on donated eggs with those who relied on donated embryos, we examined the meaning of the absence of a genetic tie to a child in the two different situations - that of "genetic symmetry" where neither parent has a genetic tie to that of "genetic asymmetry" where only the mother does not have a genetic tie...
March 28, 2016: Facts, Views & Vision in ObGyn
https://www.readbyqxmd.com/read/27795455/blood-soy-milk-and-vitality-the-wartime-origins-of-blood-banking-in-china-1943-45
#18
Wayne Soon
This article examines the multiple meanings of blood transfusion and banking in modern China through the history of the first Chinese blood bank, established by the Overseas Chinese in 1943 to solicit blood for the war effort. Through investigating the attitudes of Chinese soldiers and civilians toward the blood bank, this article argues for the multiplicity of motivations underpinning society's attitudes toward blood banking and donation. Cultural notions of blood were an important but not the sole factor in their consideration...
2016: Bulletin of the History of Medicine
https://www.readbyqxmd.com/read/27774232/gamete-donor-anonymity-and-limits-on-numbers-of-offspring-the-views-of-three-stakeholders
#19
Margaret K Nelson, Rosanna Hertz, Wendy Kramer
This paper discusses the attitudes of three groups of stakeholders in the world of assisted reproduction gamete donors, parents who use donated gamete, and offspring conceived with donated gametes with respect to the two issues of donor anonymity and limits on the number of offspring a single donor can produce. The data are drawn from on-line surveys which were made available between May 12, 2104 and August 15, 2014 to gamete donors, donor-conceived offspring, and parents who used donated gametes to conceive...
April 2016: Journal of Law and the Biosciences
https://www.readbyqxmd.com/read/27751789/variation-of-maternal-kir-and-fetal-hla-c-genes-in-reproductive-failure-too-early-for-clinical-intervention
#20
Ashley Moffett, Olympe Chazara, Francesco Colucci, Martin H Johnson
A distinctive type of (uterine) natural killer (NK) cell is present in the uterine decidua during the period of placental formation. Uterine NK cells express members of the killer immunoglobulin-like receptor (KIR) family that bind to parental HLA-C molecules on the invading placental trophoblast cells. The maternal KIR genes and their fetal ligands are highly variable, so different KIR/HLA-C genetic combinations occur in each pregnancy. Some women only possess inhibitory KIR genes, whereas other women also express activating KIR genes...
December 2016: Reproductive Biomedicine Online
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