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https://www.readbyqxmd.com/read/29141674/repair-of-articular-cartilage-and-subchondral-defects-in-rabbit-knee-joints-with-a-polyvinyl-alcohol-nano-hydroxyapatite-polyamide-66-biological-composite-material
#1
Tao Guo, Xiaobin Tian, Bo Li, Tianfu Yang, Yubao Li
BACKGROUND: This study sought to prepare a new PVA/n-HA/PA66 composite to investigate the repair of articular cartilage and subchondral defects in rabbit knee joints. METHODS: A 5 × 5 × 5 mm-sized defect was created in the patellofemoral joints of 72 healthy adult New Zealand rabbits. The rabbits were then randomly divided into three groups (n = 24): PVA/n-HA+PA66 group, polyvinyl alcohol (PVA) group, and control (untreated) group. Cylindrical PVA/n-HA+PA66, 5 × 5 mm, comprised an upper PVA layer and a lower n-HA+PA66 layer...
November 15, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29114928/a-new-substitute-for-formalin-application-to-embalming-cadavers
#2
Yoshinori Haizuka, Miki Nagase, Satoshi Takashino, Yasushi Kobayashi, Yoshihisa Fujikura, George Matsumura
The development of formalin-free fixatives is an urgent issue in gross anatomy because of the health hazard and the tissue-hardening actions of formalin. We recently identified the fixative, antimicrobial, and preservative effects of N-vinyl-2-pyrrolidone (NVP), a precursor of the water-soluble macromolecular polymer polyvinylpyrrolidone, in animal experiments. The aim of the present study is to investigate whether NVP solution can be used as an alternative to formalin in human cadaveric dissection. Twelve donated cadavers were infused with NVP via the femoral and common carotid arteries using a peristaltic pump...
November 7, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/29066105/in%C3%A2-vivo-kinematic-comparison-of-a-bicruciate-stabilized-total-knee-arthroplasty-and-the-normal-knee-using-fluoroscopy
#3
Trevor F Grieco, Adrija Sharma, Garett M Dessinger, Harold E Cates, Richard D Komistek
BACKGROUND: The bicruciate stabilized (BCS) total knee arthroplasty (TKA) features asymmetrical bearing geometry and dual substitution for the anterior cruciate ligament and posterior cruciate ligament (PCL). Previous TKA designs have not fully replicated normal knee motion, and they are characterized by lower magnitudes of overall rollback and axial rotation than the normal knee. METHODS: In vivo kinematics were derived for 10 normal knees and 40-second generation BCS TKAs all implanted by a single surgeon...
September 25, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29033262/primary-stability-of-different-plate-positions-and-the-role-of-bone-substitute-in-open-wedge-high-tibial-osteotomy
#4
Ryohei Takeuchi, Jung Woon-Hwa, Hiroyuki Ishikawa, Yuichiro Yamaguchi, Katsunari Osawa, Yasushi Akamatsu, Koichi Kuroda
BACKGROUND: The purpose of this study was to compare the mechanical fixation strengths of anteromedial and medial plate positions in osteotomy, and clarify the effects of bone substitute placement into the osteotomy site. METHODS: Twenty-eight sawbone tibia models were used. Four different models were prepared: Group A, the osteotomy site was open and the plate position was anteromedial; Group B, bone substitutes were inserted into the osteotomy site and the plate position was anteromedial; Group C, the osteotomy site was open and the plate position was medial; and Group D, bone substitutes were inserted into the osteotomy site and the plate position was medial...
October 12, 2017: Knee
https://www.readbyqxmd.com/read/28970121/preoperative-knee-deformity-and-kinematics-impact-postoperative-knee-kinematics-in-total-knee-arthroplasty
#5
Naoki Seito, Tomohiro Onodera, Yasuhiko Kasahara, Eiji Kondo, Norimasa Iwasaki, Tokifumi Majima
BACKGROUND: The purpose of this study was to evaluate the relationship between the preoperative knee deformity/kinematic pattern and the postoperative knee kinematic pattern in posterior cruciate ligament substituting (PS)-total knee arthroplasty (TKA). METHODS: This study involved 39 patients with medial osteoarthritis who underwent a primary PS-TKA using a computed-tomography-based navigation system. All the operations were performed by a single surgeon using a subvastus approach, modified gap technique and the same PS type of prosthesis (Genesis II™ total knee system, Smith & Nephew, Memphis, TN, USA)...
September 29, 2017: Knee
https://www.readbyqxmd.com/read/28870053/-domestic-external-fixator-application-in-the-treatment-of-limb-deformities-7-289-cases-application-report
#6
S H Qin, B F Guo, X J Zheng, S F Jiao, H T Xia, A M Peng, Q Pan, J C Zang, Z J Wang
Objective: To discuss the clinical application and effects of domestic external fixator in the treatment of patients with malformations of limbs. Methods: A total of 7 289 patients with malformation of limbs who had been operated in Qin Sihe orthopedic surgery team from January 1989 to June 2016 were retrospective analyzed. The patients were treated with domestic external fixator, including 4 033 males and 3 256 females, aging from 2 to 82 years with a mean age of 23.4 years. There were 2 732 patients using Ilizarov external fixator, 4 713 patients using hybrid external fixator, 57 patients using monobrachial external fixator, 232 patients using Ilizarov external fixator and hybrid external fixator...
September 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28859517/a-novel-approach-for-meniscal-regeneration-using-kartogenin-treated-autologous-tendon-graft
#7
He Huang, Hongyao Xu, Jianning Zhao
BACKGROUND: The meniscus is one of the most commonly injured parts of the body, and meniscal healing is difficult. HYPOTHESIS: Kartogenin (KGN) induces tendon stem cells (TSCs) to differentiate into cartilage cells in vitro and form meniscus-like tissue in vivo. A damaged meniscus can be replaced with a KGN-treated autologous tendon graft. STUDY DESIGN: Controlled laboratory study. METHODS: In the in vitro experiments, TSCs were isolated from rabbit patellar tendons and cultured with various concentrations of KGN, from 0 to 1000 µM...
August 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28844415/novel-curved-surface-preparation-technique-for-knee-resurfacing
#8
Jianmo Li, Susannah Clarke, Justin P Cobb, Andrew A Amis
Conventional tools are incapable of preparing the curved articular surface geometry required during cartilage repair procedures. A novel curved surface preparation technique was proposed and tested to provide an accurate low-cost solution. Three shapes of samples, with flat, 30 mm radius and 60 mm radius surfaces, were manufactured from foam bone substitute for testing. Registering guides and cutting guides were designed and 3-D printed to fit onto the foam samples. A rotational cutting tool with an adapter was used to prepare the surfaces following the guidance slots in the cutting guides...
November 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28797873/radiographic-and-computed-tomographic-evaluation-of-bone-union-after-medial-opening-wedge-high-tibial-osteotomy-with-filling-gap
#9
Hideo Kobayashi, Yasushi Akamatsu, Ken Kumagai, Yoshihiro Kusayama, Tomoyuki Saito
BACKGROUND: We evaluated bone union and remodelling in patients undergoing opening-wedge high tibial osteotomy (OWHTO) with bone gaps filled with beta-tricalcium phosphate. We examined the effectiveness of radiography and computed tomography (CT) for the evaluation of bone union and remodelling, and investigated whether lateral hinge fractures affected bone union. METHODS: Sixty-six cases underwent OWHTO with a combination of a TomoFix plate and a bone substitute...
August 7, 2017: Knee
https://www.readbyqxmd.com/read/28769981/human-suprapatellar-fat-pad-derived-mesenchymal-stem-cells-induce-chondrogenesis-and-cartilage-repair-in-a-model-of-severe-osteoarthritis
#10
Ignacio Muñoz-Criado, Jose Meseguer-Ripolles, Maravillas Mellado-López, Ana Alastrue-Agudo, Richard J Griffeth, Jerónimo Forteza-Vila, Ramón Cugat, Montserrat García, Victoria Moreno-Manzano
Cartilage degeneration is associated with degenerative bone and joint processes in severe osteoarthritis (OA). Spontaneous cartilage regeneration is extremely limited. Often the treatment consists of a partial or complete joint implant. Adipose-derived stem cell (ASC) transplantation has been shown to restore degenerated cartilage; however, regenerative differences of ASC would depend on the source of adipose tissue. The infra- and suprapatellar fat pads surrounding the knee offer a potential autologous source of ASC for patients after complete joint substitution...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28757192/delivery-of-epidermal-growth-factor-receptor-inhibitor-via-a-customized-collagen-scaffold-promotes-meniscal-defect-regeneration-in-a-rabbit-model
#11
Zongyou Pan, Yan Wu, Xiaolei Zhang, Qianbao Fu, Jun Li, Yang Yang, Dongsheng Yu, Yuzi Xu, Xiaolang Lu, Heng Sun, Xianzhu Zhang, Boon Chin Heng, Varitsara Bunpetch, Shufang Zhang, Hongwei Ouyang
Meniscal injury is one of the most common knee joint injuries, which remains an intractable challenge in clinical practice to date. Aberrant epidermal growth factor receptor (EGFR) activation levels in both human and mice menisci following injury, prompted us to investigate the functional role of EGFR by utilizing an inducible cartilage-specific EGFR-deficient mouse model. We demonstrated that conditional EGFR deletion in mice resulted in increased partial meniscectomy-induced ECM production within the meniscus, which is comparable to utilization of the small molecule EGFR inhibitor, gefitinib, to block EGFR activity...
July 28, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28743140/a-comparison-of-rollback-ratio-between-bicruciate-substituting-total-knee-arthroplasty-and-oxford-unicompartmental-knee-arthroplasty
#12
Takanori Iriuchishima, Keinosuke Ryu
No abstract text is available yet for this article.
July 25, 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/28702392/subchondroplasty-for-treating-bone-marrow-lesions-in-the-knee-initial-experience
#13
Marcelo Batista Bonadio, Pedro Nogueira Giglio, Camilo Partezani Helito, José Ricardo Pécora, Gilberto Luis Camanho, Marco Kawamura Demange
OBJECTIVE: To evaluate the use of subchondroplasty in the treatment of bone marrow lesions in an initial series of five cases. METHODS: The study included patients aged between 40 and 75 years old, with pain in the knee for at least six months, associated with high-signal MRI lesion on T2 sequences, on the tibia or femur. Patients were assessed using the visual analog pain scale and the KOOS score, one week before surgery and one, three, six, 12, and 24 weeks after the procedure...
May 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/28678126/the-effect-on-long-term-survivorship-of-surgeon-preference-for-posterior-stabilized-or-minimally-stabilized-total-knee-replacement-an-analysis-of-63-416-prostheses-from-the-australian-orthopaedic-association-national-joint-replacement-registry
#14
Christopher J Vertullo, Peter L Lewis, Michelle Lorimer, Stephen E Graves
BACKGROUND: Controversy still exists as to the optimum management of the posterior cruciate ligament (PCL) in total knee arthroplasty. Surgeons can choose to kinematically substitute the PCL with a posterior-stabilized total knee replacement or alternatively to utilize a cruciate-retaining, also known as minimally stabilized, total knee replacement. Proponents of posterior-stabilized total knee replacement propose that the reported lower survivorship in registries when directly compared with minimally stabilized total knee replacement is due to confounders such as selection bias because of the preferential usage of posterior-stabilized total knee replacement in more complex or severe cases...
July 5, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28601246/clinical-outcome-of-medial-pivot-compared-with-press-fit-condylar-sigma-cruciate-retaining-mobile-bearing-total-knee-arthroplasty
#15
Young-Hoo Kim, Jang-Won Park, Jun-Shik Kim
BACKGROUND: The purpose of this study was to compare the long-term clinical results, radiographic results, range of knee motion, patient satisfaction, and the survival rate of Medial-Pivot posterior cruciate-substituting, knee prosthesis and a press-fit condylar (PFC) Sigma cruciate-retaining mobile-bearing knee prosthesis in the same patients. METHODS: One hundred eighty-two patients received Medial-Pivot knee prosthesis in one knee and a PFC Sigma knee prosthesis in the contralateral knee...
May 18, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28590468/the-influence-of-cation-ordering-oxygen-vacancy-distribution-and-proton-siting-on-observed-properties-in-ceramic-electrolytes-the-case-of-scandium-substituted-barium-titanate
#16
Nico Torino, Paul F Henry, Christopher S Knee, Tor Svendsen Bjørheim, Seikh M H Rahman, Emma Suard, Carlotta Giacobbe, Sten G Eriksson
The origin of the 2-order of magnitude difference in the proton conductivity of the hydrated forms of hexagonal and cubic oxygen deficient BaScxTi1-xO3-δ (x = 0.2 and x = 0.7) was probed using a combination of neutron diffraction and density functional theory techniques to support published X-ray diffraction, conductivity, thermogravimetric and differential scanning calorimetry studies. Cation ordering is found in the 6H structure type (space group P63/mmc) adopted by BaSc0.2Ti0.8O3-δ with scandium preferentially substituting in the vertex sharing octahedra (2a crystallographic site) and avoiding the face-sharing octahedra (4f site)...
June 7, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28589079/role-of-light-in-the-pathogenesis-of-joint-destruction-in-rheumatoid-arthritis
#17
Afsie Sabokbar, Sara Afrough, David J Mahoney, Yoshinobu Uchihara, Catherine Swales, Nicholas A Athanasou
AIM: To characterise the role of substitutes for receptor-activator nuclear factor kappa-B ligand (RANKL) in rheumatoid arthritis (RA) joint destruction. METHODS: Synovial fluid (SF) macrophages isolated from the knee joint of RA patients were incubated with 25 ng/mL macrophage-colony stimulating factor (M-CSF) and 50 ng/mL LIGHT (lymphotoxin-like, exhibits inducible expression and competes with herpes simplex virus glycoprotein D for herpes virus entry mediator, a receptor expressed by T lymphocytes) in the presence and absence of 25 ng/mL RANKL and 100 ng/mL osteoprotegerin (OPG) on glass coverslips and dentine slices...
May 20, 2017: World Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28559197/anteroposterior-rotational-references-of-the-tibia-for-medial-unicompartmental-knee-arthroplasty-in-japanese-patients
#18
Ichiro Tsukamoto, Masao Akagi, Shigeshi Mori, Shinji Inoue, Shigeki Asada, Fuminori Matsumura
BACKGROUND: In unicompartmental knee arthroplasty (UKA), there is no consensus regarding how to determine the anteroposterior (AP) reference of the tibia. A number of surgeons in Japan perform the sagittal saw cut using the medial intercondylar ridge (MIR) of the tibia according to surgical manuals. However, there is no theoretical basis for this practice. METHODS: Preoperative computed tomography data from 32 lower limbs of 31 Japanese patients who received UKA were used...
May 4, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28558843/the-effectiveness-of-a-de-implementation-strategy-to-reduce-low-value-blood-management-techniques-in-primary-hip-and-knee-arthroplasty-a-pragmatic-cluster-randomized-controlled-trial
#19
Veronique M A Voorn, Perla J Marang-van de Mheen, Anja van der Hout, Stefanie N Hofstede, Cynthia So-Osman, M Elske van den Akker-van Marle, Ad A Kaptein, Theo Stijnen, Ankie W M M Koopman-van Gemert, Albert Dahan, Thea P M M Vliet Vlieland, Rob G H H Nelissen, Leti van Bodegom-Vos
BACKGROUND: Perioperative autologous blood salvage and preoperative erythropoietin are not (cost) effective to reduce allogeneic transfusion in primary hip and knee arthroplasty, but are still used. This study aimed to evaluate the effectiveness of a theoretically informed multifaceted strategy to de-implement these low-value blood management techniques. METHODS: Twenty-one Dutch hospitals participated in this pragmatic cluster-randomized trial. At baseline, data were gathered for 924 patients from 10 intervention and 1040 patients from 11 control hospitals undergoing hip or knee arthroplasty...
May 30, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28433427/do-medial-pivot-kinematics-correlate-with-patient-reported-outcomes-after-total-knee-arthroplasty
#20
Lucian C Warth, Marshall K Ishmael, Evan R Deckard, Mary Ziemba-Davis, R Michael Meneghini
BACKGROUND: Many total knee arthroplasty (TKA) implants are designed to facilitate a medial pivot kinematic pattern. The purpose of this study was to determine whether intraoperative medial pivot kinematic patterns are associated with improved patient outcomes. METHODS: A retrospective review of consecutive primary TKAs was performed. Sensor-embedded tibial trials determined kinematic patterns intraoperatively. The center of rotation (COR) was identified from 0° to 90° and from 0° to terminal flexion, and designated medial-pivot or non-medial pivot based on accepted criteria...
March 18, 2017: Journal of Arthroplasty
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