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https://www.readbyqxmd.com/read/29232689/a-computational-model-for-regulation-of-nanoscale-glucan-exposure-in-candida-albicans
#1
Michael J Wester, Jia Lin, Aaron K Neumann
Candida albicans is a virulent human opportunistic pathogen. It evades innate immune surveillance by masking an immunogenic cell wall polysaccharide, β-glucan, from recognition by the immunoreceptor Dectin-1. Glucan unmasking by the antifungal drug caspofungin leads to changes in the nanostructure of glucan exposure accessible to Dectin-1. The physical mechanism that regulates glucan exposure is poorly understood, but it controls the nanobiology of fungal pathogen recognition. We created computational models to simulate hypothetical physical processes of unmasking glucan in a biologically realistic distribution of cell wall glucan fibrils...
2017: PloS One
https://www.readbyqxmd.com/read/29228372/a-novel-tomographic-imaging-probe-for-rapid-diagnosis-of-fungal-keratitis
#2
Min Hee Lee, Gregory Wiedman, Steven Park, Arkady Mustaev, Yanan Zhao, David S Perlin
Fungal keratitis is a leading cause of ocular morbidity and blindness in developing countries. Diagnosing fungal keratitis currently relies on a comparative evaluation of corneal biopsy or scraping using a direct microscopy and culture results. These methods not only carry the risk of developing complications due to the invasive tissue sampling but also are largely limited by diagnostic speed and accuracy, making it difficult to initiate timely appropriate antifungal therapy. Therefore, rapid and noninvasive diagnostic tools are a pressing need for improved outcomes for fungal keratitis...
December 8, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29209049/repurposing-an-inhibitor-of-ribosomal-biogenesis-with-broad-anti-fungal-activity
#3
Nuo Sun, Dongmei Li, Yuhan Zhang, Kyle Killeen, William Groutas, Richard Calderone
The lack of new antifungal compounds with unique mechanisms of action is a concern for therapeutic management of patients. To identify inhibitors against human pathogenic fungi, we screened ~3000 compounds provided by the Developmental Therapeutics Program of NIH/NCI against a panel of pathogenic fungi including Candida species, Aspergillus fumigatus, and Cryptococcus neoformans. NSC319726 (a thiosemicarbazone) had broad antifungal activity in the range of 0.1-2.0 µg/ml and was also inhibitory to fluconazole-resistant isolates of Candida species...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29203491/chemogenomic-profiling-of-the-fungal-pathogen-candida-albicans
#4
Yaolin Chen, Jaideep Mallick, Alaa Maqnas, Yuan Sun, Baharul I Choudhury, Pierre Cote, Lan Yan, Ting-Jun-Hong Ni, Yan Li, Dazhi Zhang, Roberto Rodríguez-Ortiz, Quan-Zhen Lv, Yuan-Ying Jiang, Malcolm Whiteway
There are currently a small number of classes of antifungal drugs, and these drugs are known to target a very limited set of cellular functions. We derived a set of approximately 900 non-essential, transactivator-defective disruption strains from the tetracycline regulated GRACE strain collection of the fungal pathogen Candida albicans This strain set was screened against classic antifungal drugs to identify gene inactivations that conferred either enhanced sensitivity or increased resistance to the compounds...
December 4, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29190379/fungal-specific-cyp51-inhibitor-vt-1598-demonstrates-in-vitro-activity-against-candida-and-cryptococcus-species-endemic-fungi-including-coccidioides-species-aspergillus-species-and-rhizopus-arrhizus
#5
Nathan P Wiederhold, Hoja P Patterson, Bich Hue Tran, Christopher M Yates, Robert J Schotzinger, Edward P Garvey
Background: Invasive fungal infections, including those caused by yeasts, moulds and endemic organisms, can be significant causes of morbidity and mortality in immunocompromised hosts, those with multiple comorbidities and occasionally immunocompetent hosts. Current antifungal agents are often limited by drug toxicities, drug interactions or the development of resistance. VT-1598 is a novel tetrazole that has greater specificity for fungal Cyp51 than currently available triazoles and thus the potential for clinically significant drug interactions is reduced...
November 27, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29188178/tumor-shape-pulmonary-mucormycosis-associated-with-sinonasal-aspergillosis-in-a-diabetic-patient
#6
Sophie Point, Frédéric Gabriel, Hugues Bégueret, Jacques Jougon, Fanny Lanternier, Frédéric Grenouillet, Manal Abdel Fattah, Emilie Catherinot, Chantal Raherison, Elodie Blanchard
Mucormycosis is a rare and life-threatening fungal infection of the Mucorales order occurring mainly in immunosuppressed patients. The most common forms are rhinocerebral but pulmonary or disseminated forms may occur. We report the case of a 61-year-old patient in whom pulmonary mucormycosis was diagnosed during his first-ever episode of diabetic ketoacidosis. While receiving liposomal amphotericin B, a sinusal aspergillosis due to Aspergillus fumigatus occurred. Evolution was slowly favorable under antifungal tritherapy by liposomal amphotericin B, posaconazole and caspofungin...
March 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29185089/pharmacoeconomic-evaluation-of-micafungin-versus-caspofungin-as-definitive-therapy-for-candidaemia-and-invasive-candidiasis-ic-in-turkey
#7
C F Neoh, E Senol, A Kara, E C Dinleyici, S J Turner, D C M Kong
Micafungin was shown to be as efficacious as caspofungin in treating patients with candidaemia and invasive candidiasis (IC). However, it remains unknown if micafungin or caspofungin is a cost-effective definitive therapy for candidaemia and IC in Turkey. The present study aimed to determine the economic impact of using micafungin versus caspofungin for treatment of candidaemia and IC in the Turkish setting. A decision analytic model was constructed and was populated with data (i.e. transition probabilities, duration of initial antifungal treatment, reasons for treatment failure, percentage of patients who stepped down to oral fluconazole, and duration on oral fluconazole) obtained from a published randomised clinical trial...
November 28, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29183771/comparative-study-for-147-candida-spp-identification-and-echinocandins-susceptibility-in-isolates-obtained-from-blood-cultures-in-15-hospitals-medellin-colombia
#8
Indira Berrio, Natalia Maldonado, Catalina De Bedout, Karen Arango, Luz Elena Cano, Yorlady Valencia, Cristina Jiménez-Ortigosa, David S Perlin, Beatriz L Gómez, Carlos Robledo, Jaime Robledo
INTRODUCTION: Invasive candidiasis has high impact on morbidity and mortality in hospitalized patients. Accurate and timely methods for identification of Candida species and determination of equinocandins susceptibility become a priority for laboratories of clinical microbiology. METHODS: A study was performed to compare MALDI-TOF MS identification to sequencing of D1/D2 region of rRNA gene complex 28 subunit, in 147 isolates obtained from patients with candidemia...
November 25, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29177447/oral-glucan-synthase-inhibitor-scy-078-is-effective-in-an-experimental-murine-model-of-invasive-candidiasis-caused-by-wt-and-echinocandin-resistant-candida-glabrata
#9
Nathan P Wiederhold, Laura K Najvar, Rosie Jaramillo, Marcos Olivo, Jason Pizzini, Gabriel Catano, Thomas F Patterson
Background: Echinocandins are recommended as first-line therapy against Candida glabrata infections, although increased resistance to this class has been reported worldwide and they are currently only available for parenteral administration. SCY-078 is an investigational glucan synthase inhibitor that is orally available. Objectives: To evaluate the in vivo efficacy of SCY-078 in an experimental model of invasive candidiasis due to WT and echinocandin-resistant C...
November 21, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29172033/in-vitro-antifungal-susceptibility-of-clinical-and-environmental-isolates-of-aspergillus-fumigatus-and-aspergillus-flavus-in-brazil
#10
Laura Bedin Denardi, Bianca Hoch Dalla-Lana, Francielli Pantella Kunz de Jesus, Cecília Bittencourt Severo, Janio Morais Santurio, Régis Adriel Zanette, Sydney Hartz Alves
The in vitro susceptibility of 105 clinical and environmental strains of Aspergillus fumigatus and Aspergillus flavus to antifungal drugs, such as amphotericin B, azoles, and echinocandins was evaluated by the broth microdilution method proposed by the European Committee on Antimicrobial Susceptibility Testing (EUCAST). Following the EUCAST-proposed breakpoints, 20% and 25% of the clinical and environmental isolates of A. fumigatus, respectively, were found to be resistant to itraconazole (Minimal Inhibitory Concentration, MIC>2...
November 21, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29157206/antifungal-susceptibility-testing-of-candida-species-isolated-from-the-immunocompromised-patients-admitted-to-ten-university-hospitals-in-iran-comparison-of-colonizing-and-infecting-isolates
#11
Parisa Badiee, Hamid Badali, Teun Boekhout, Kambiz Diba, Abdolkarim Ghadimi Moghadam, Ali Hossaini Nasab, Hadis Jafarian, Rasoul Mohammadi, Hossein Mirhendi, Mohammad Javad Najafzadeh, Ahmad Shamsizadeh, Jafar Soltani
BACKGROUND: Antifungal susceptibility testing is a subject of interest in the field of medical mycology. The aim of the present study were the distributions and antifungal susceptibility patterns of various Candida species isolated from colonized and infected immunocompromised patients admitted to ten university hospitals in Iran. METHODS: In totally, 846 Candida species were isolated from more than 4000 clinical samples and identified by the API 20 C AUX system...
November 21, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29145348/magnusiomyces-capitatus-peritonitis-in-a-child-with-acute-lymphocytic-leukemia-as-a-breakthrough-infection-during-caspofungin-therapy
#12
Ayşe Bariş, Haşim Gencer, Nazan Dalgiç, Güntülü Şik, Fatma Özakkaş, Elif Aktaş
Magnusiomyces capitatus is an emerging opportunistic fungal pathogen particularly in immunocompromised patients. We report a case of a M. capitatus peritonitis in child with acute lymphocytic leukemia as a breakthrough infection during caspofungin therapy. The possibility of breakthrough infections caused by M. capitatus must be taken into consideration, particularly in immunosupressed patients being treated for systemic fungal infections by caspofungin. Although there are no defined breakpoints for susceptibility testing of M...
December 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29137050/uncommon-cause-of-fungemia-in-a-patient-with-renal-cell-cancer-a-case-report-of-candida-lusitaniae-fungemia
#13
Rashmi Mishra, Paul Kelly, Omesh Toolsie, Puvvalingam Ayyadurai, Muhammad Adrish
INTRODUCTION: We present an interesting case of Candida lusitaniae infection in a patient diagnosed with renal clear cell carcinoma.An 82-year-old male presented with worsening back pain for 1 week. Physical examination including neurologic examination was normal. A computed tomography scan of the abdomen revealed a mass in the right upper pole of the kidney suggestive of a renal neoplasm. Pathology from a percutaneous biopsy of the kidney revealed clear cell carcinoma. During his hospitalization the patient developed fungemia due to C lusitaniae...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29127050/do-antibacterial-and-antifungal-combinations-have-better-activity-against-clinically-relevant-fusarium-species-in-vitro-synergism
#14
Tarcieli Pozzebon Venturini, Abdullah M S Al-Hatmi, Luana Rossato, Maria Isabel Azevedo, Jéssica Tairine Keller, Carla Weiblen, Janio Morais Santurio, Sydney Hartz Alves
The objective of this study was to evaluate the susceptibility of 20 clinical isolates of Fusarium spp. against classic antifungals (amphotericin B [AMB], itraconazole [ITC], voriconazole [VRC] and caspofungin [CAS]) and to nonantifungal agents (amiodarone [AMD], doxycycline [DOX] and moxifloxacin [MXF]) using broth microdilution method. The combinations between these antifungal plus nonantifungal agents were also evaluated for the determination of FICI (fractional inhibitory concentration index) using the checkerboard technique...
November 7, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29120502/necrotizing-microascus-tracheo-bronchitis-in-a-bilateral-lung-transplant-recipient
#15
Olivier Taton, Benjamin Bernier, Isabelle Etienne, Benjamin Bondue, Sophie Lecomte, Christiane Knoop, Frederique Jacob, Isabel Montesinos
Invasive fungal infections are a major cause of mortality among solid organ transplant recipients. Scopulariopsis species and their teleomorph Microascus are molds found in soil and decaying organic matter. We report here the case of a woman who underwent bilateral lung transplantation for severe emphysema. On day 25 after transplantation, endobronchial green-black lesions were detected during routine endoscopy. Endobronchial swabs, biopsies, and broncho-alveolar lavage samples were positive for Microascus cirrosus...
November 9, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29104569/a-linear-19-mer-plant-defensin-derived-peptide-acts-synergistically-with-caspofungin-against-candida-albicans-biofilms
#16
Tanne L Cools, Caroline Struyfs, Jan W Drijfhout, Soňa Kucharíková, Celia Lobo Romero, Patrick Van Dijck, Marcelo H S Ramada, Carlos Bloch, Bruno P A Cammue, Karin Thevissen
Public health problems are associated with device-associated biofilm infections, with Candida albicans being the major fungal pathogen. We previously identified potent antibiofilm combination treatment in which the antifungal plant defensin HsAFP1 is co-administered with caspofungin, the preferred antimycotic to treat such infections. In this study, we identified the smallest linear HsAFP1-derived peptide that acts synergistically with caspofungin or anidulafungin against C. albicans as HsLin06_18, a 19-mer peptide derived from the C-terminal part of HsAFP1...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29103728/short-communication-cold-atmospheric-plasma-inactivation-of-prototheca-zopfii-isolated-from-bovine-milk
#17
E Tyczkowska-Sieron, J Markiewicz, B Grzesiak, H Krukowski, A Glowacka, J Tyczkowski
Mastitis is a serious bovine diseases that can be caused by Prototheca zopfii, yeast-like algae belonging to the family Chlorellaceae. The substantial economic losses and health damage associated with bovine mastitis emphasize the need to develop effective strategies aimed at control of the infection. Unfortunately, P. zopfii is highly resistant to most common antibacterial and antifungal agents, as well as to heat treatment. We report here the first attempt to use cold atmospheric plasma to inactivate this pathogen...
November 2, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29065462/cinnamic-acid-analogs-as-intervention-catalysts-for-overcoming-antifungal-tolerance
#18
Jong H Kim, Kathleen L Chan, Luisa W Cheng
Disruption of fungal cell wall should be an effective intervention strategy. However, the cell wall-disrupting echinocandin drugs, such as caspofungin (CAS), cannot exterminate filamentous fungal pathogens during treatment. For potency improvement of cell wall-disrupting agents (CAS, octyl gallate (OG)), antifungal efficacy of thirty-three cinnamic acid derivatives was investigated against Saccharomyces cerevisiaeslt2Δ, bck1Δ, mutants of the mitogen-activated protein kinase (MAPK), and MAPK kinase kinase, respectively, in cell wall integrity system, and glr1Δ, mutant of CAS-responsive glutathione reductase...
October 21, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29062248/evaluation-of-candida-species-and-antifungal-susceptibilities-among-children-with-invasive-candidiasis
#19
Murat Sütçü, Manolya Acar, Gonca Erköse Genç, İlknur Kökçü, Hacer Aktürk, Gürkan Atay, Selda Hançerli Törun, Nuran Salman, Zayre Erturan, Ayper Somer
AIM: Non-albicans Candida species and resistant microorganisms have been more commonly isolated in invasive candidiasis in recent years. The aim of this study was to evaluate the distrubution of Candida spp and antifungal resistance in our clinic. MATERIAL AND METHODS: Fifty-four Candida isolates and antifungal susceptibility results obtained from patients diagnosed as having invasive candidiasis between December 2012 and June 2016 were included. Clinical and laboratory data were retrospectively analyzed...
September 2017: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/29061737/the-antifungal-activity-of-oleylphosphocholine-olpc-on-in-vitro-and-in-vivo-candida-albicans-biofilms
#20
Michelle Holtappels, Erwin Swinnen, Lies De Groef, Jurgen Wuyts, Lieve Moons, Katrien Lagrou, Patrick Van Dijck, Soňa Kucharíková
In this study, we investigated the potential antifungal activity of the alkylphospholipid - oleylphosphocholine (OlPC), a structural analogue of miltefosine, on in vitro and in vivo Candida albicans biofilm formation. The effect of OlPC on in vitro and in vivo C. albicans biofilms was studied inside triple-lumen polyurethane catheters. In vivo biofilms were developed subcutaneously after catheter implant on the lower back of Sprague Dawley rats. Animals were treated orally with OlPC (20 mg/kg of body weight/day) for 7 days...
October 23, 2017: Antimicrobial Agents and Chemotherapy
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