keyword
https://read.qxmd.com/read/38524933/effects-of-simultaneous-pancreas-and-kidney-transplantation-in-japanese-individuals-with-type-1-diabetes-and-end-stage-kidney-disease
#1
JOURNAL ARTICLE
Tomomi Mori, Izumi Nyumura, Ko Hanai, Tomohiro Shinozaki, Tetsuya Babazono
This single-center observational cohort study aimed to assess the potential benefits of simultaneous pancreas and kidney transplantation (SPK) in terms of mortality and kidney graft outcomes in Japanese individuals with type 1 diabetes (T1D) and end-stage kidney disease (ESKD). We first compared all-cause mortality rates between 78 SPK recipients and 108 non-transplanted individuals with T1D and ESKD. To mitigate the bias stemming from immortal time before receiving SPK, we utilized Cox regression models treating SPK as a time-dependent covariate...
April 2024: Diabetology International
https://read.qxmd.com/read/38483593/evaluation-and-post-transplant-management-of-children-after-multi-organ-with-kidney-transplantation
#2
REVIEW
Rachel M Engen, Caroline P Lemoine
Multi-organ transplantation involves the transplant of two or more organs from a single donor into a single recipient; in most cases, one of these organs is a kidney. Multi-organ transplantation is uncommon in pediatric transplantation but can be life-saving or significantly life-improving for children with rare diseases, including primary heart, liver, pancreas, or intestinal failure with secondary kidney failure, metabolic disorders, and genetic conditions causing multi-organ dysfunction. This manuscript reviews the current state of pediatric multi-organ transplantation that includes a kidney, with a focus on indications, evaluation, and key differences in management compared to kidney-alone transplantation...
March 14, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38444997/infection-related-hospitalizations-after-simultaneous-pancreas-kidney-transplantation-compared-to-kidney-transplantation-alone
#3
JOURNAL ARTICLE
Juulia Grasberger, Fernanda Ortiz, Agneta Ekstrand, Ville Sallinen, Kaisa Ahopelto, Patrik Finne, Mika Gissler, Marko Lempinen, Ilkka Helanterä
The total burden of infections after transplantation has not been compared in detail between recipients of simultaneous pancreas-kidney transplantation (SPK) and kidney transplantation alone (KTA). We compared infection-related hospitalizations and bacteremias after transplantation during 1- and 5-year follow-up among 162 patients undergoing SPK. The control group consisted of 153 type 1 diabetics undergoing KTA with the inclusion criteria of donor and recipient age < 60, and BMI < 30. During the first year, SPK patients had more infection-related hospitalizations (0...
2024: Transplant International
https://read.qxmd.com/read/38431358/optn-srtr-2022-annual-data-report-pancreas
#4
JOURNAL ARTICLE
Raja Kandaswamy, Peter G Stock, Jonathan M Miller, Sarah E Booker, Joann White, Ajay K Israni, Jon J Snyder
The postpandemic recovery did not occur in pancreas transplantation as in other organs. The number of pancreas transplants in the United States decreased to 918 in 2022 from 963 in 2021. The number of simultaneous pancreas-kidney transplants decreased to 810 in 2022 from 820 in 2021, but the largest decrease was in pancreas transplant alone: 62 in 2022 compared with 92 in 2021. Pancreas-after-kidney transplants decreased to 46 in 2022 from 51 in 2021. The trend of increasing proportions of pancreas transplants in patients with type 2 diabetes seen over the past few years ended in 2022; there were 22...
February 2024: American Journal of Transplantation
https://read.qxmd.com/read/38408641/excess-waitlist-mortality-among-candidates-for-multivisceral-liver-intestine-transplant-in-acuity-circle-allocation
#5
JOURNAL ARTICLE
Allison J Kwong, Erin Schnellinger, Julia Foutz, Matt Cafarella, Shunji Nagai, Scott W Biggins, James Pomposelli, James Trotter
Candidates for multivisceral transplant (MVT) have experienced decreased access to transplant in recent years. Using Organ Procurement and Transplantation Network data, transplant and waiting list outcomes for MVT (ie, liver-intestine, liver-intestine-pancreas, and liver-intestine-kidney-pancreas) candidates listed between February 4, 2018, and February 3, 2022, were analyzed, including model for end-stage liver disease/pediatric end-stage liver disease and exception scores by era (before and after acuity circle [AC] implementation on February 4, 2020) and age group (pediatric and adult)...
February 24, 2024: American Journal of Transplantation
https://read.qxmd.com/read/38329115/prescription-opioids-induced-microbial-dysbiosis-worsens-severity-of-chronic-pancreatitis-and-drives-pain-hypersensitivity
#6
JOURNAL ARTICLE
Kousik Kesh, Junyi Tao, Nillu Ghosh, Richa Jalodia, Salma Singh, Rajinder Dawra, Sabita Roy
Opioids, such as morphine and oxycodone, are widely used for pain management associated with chronic pancreatitis (CP); however, their impact on the progression and pain sensitivity of CP has never been evaluated. This report investigates the impact of opioid use on the severity of CP, pain sensitivity, and the gut microbiome. C57BL/6 mice were divided into control, CP, CP with morphine/oxycodone, and either morphine or oxycodone alone groups. CP was induced by administration of caerulein (50ug/kg/h, i.p. hourly x7, twice a week for 10 weeks)...
2024: Gut Microbes
https://read.qxmd.com/read/38094132/local-postoperative-graft-inflammation-in-pancreas-transplant-patients-with-early-graft-thrombosis
#7
JOURNAL ARTICLE
Kristina Rydenfelt, Gisle Kjøsen, Rune Horneland, Judith Krey Ludviksen, Trond Geir Jenssen, Pål-Dag Line, Tor Inge Tønnessen, Tom Eirik Mollnes, Håkon Haugaa, Søren Erik Pischke
BACKGROUND: Graft thrombosis is the main cause of early graft loss following pancreas transplantation, and is more frequent in pancreas transplant alone (PTA) compared with simultaneous pancreas-kidney (SPK) recipients. Ischemia-reperfusion injury during transplantation triggers a local thromboinflammatory response. We aimed to evaluate local graft inflammation and its potential association with early graft thrombosis. METHODS: In this observational study, we monitored 67 pancreas-transplanted patients using microdialysis catheters placed on the pancreatic surface during the first postoperative week...
January 2024: Transplantation Direct
https://read.qxmd.com/read/38045788/unique-cases-of-large-and-small-bowel-obstruction-in-intraperitoneal-renal-transplantations-a-case-series-and-review-of-literature
#8
Zirong Yu, Ferdinand Ong, Vijay Kanagarajah
Bowel obstruction is a common cause for the acute abdomen with different aetiologies that shapes subsequent management plans. Small bowel obstruction often develop due to intra-abdominal adhesions in patients with prior abdominal surgery and for large bowel obstructions, more commonly due to tumours and lesions. Disruptions to normal intra-abdominal anatomy as seen in pancreatic-kidney transplantation or kidney transplant alone can result in increased risk of bowel obstruction-especially if the donor graft is implanted within the intraperitoneal plane...
November 2023: Journal of Surgical Case Reports
https://read.qxmd.com/read/38041451/impact-of-pancreas-transplantation-alone-on-kidney-function-a-multicenter-clinical-cohort-study
#9
MULTICENTER STUDY
Ravinder Jeet Kaur, Syed Saad Mujtahedi, Jonathan A Fridell, Xiomara Benavides, Byron Smith, Timothy S Larson, Shafaq R Rizvi, Aleksandra Kukla, Patrick Dean, Yogish C Kudva, Jon Odorico, Mark Stegall
Pancreas transplantation alone (PTA) is a β cell replacement option for selected patients with type 1 diabetes mellitus; concerns have been raised regarding deterioration in kidney function (KF) after PTA. This retrospective multicenter study assessed actual impact of transplantation and immunosuppression on KF in PTA recipients at three Transplant Centers. The primary composite endpoint 10 years after PTA was >50% eGFR decline, eGFR < 30 mL/min/1.73 m2 , and/or receiving a kidney transplant (KT)...
January 2024: Clinical Transplantation
https://read.qxmd.com/read/37814478/effect-of-lawsone-preconditioned-mesenchymal-stem-cells-on-the-regeneration-of-pancreatic-%C3%AE-cells-in-type-1-diabetic-rats
#10
JOURNAL ARTICLE
Javeria Masnoon, Aisha Ishaque, Irfan Khan, Asmat Salim, Nurul Kabir
Diabetes is one of the major health issues globally. Type 1 diabetes mellitus develops due to the destruction of pancreatic β cells. Mesenchymal stem cells (MSCs) having remarkable self-renewal and differentiation potential, can regenerate β cells. MSCs preconditioned with bioactive small molecules possess enhanced biological features and therapeutic potential under in vivo environment. Interestingly, compounds of naphthoquinone class possess antidiabetic and anti-inflammatory properties, and can be explored as potential candidates for preconditioning MSCs...
October 2023: Cell Biochemistry and Function
https://read.qxmd.com/read/37761001/a-supportive-role-of-mesenchymal-stem-cells-on-insulin-producing-langerhans-islets-with-a-specific-emphasis-on-the-secretome
#11
REVIEW
Ronit Vogt Sionov, Ronit Ahdut-HaCohen
Type 1 Diabetes (T1D) is a chronic autoimmune disease characterized by a gradual destruction of insulin-producing β-cells in the endocrine pancreas due to innate and specific immune responses, leading to impaired glucose homeostasis. T1D patients usually require regular insulin injections after meals to maintain normal serum glucose levels. In severe cases, pancreas or Langerhans islet transplantation can assist in reaching a sufficient β-mass to normalize glucose homeostasis. The latter procedure is limited because of low donor availability, high islet loss, and immune rejection...
September 18, 2023: Biomedicines
https://read.qxmd.com/read/37705389/bk-polyomavirus-dnaemia-in-pancreas-transplant-recipients-compared-to-pancreas-kidney-recipients
#12
JOURNAL ARTICLE
Zachary A Yetmar, Yogish C Kudva, Maria Teresa Seville, Wendelyn Bosch, Patrick G Dean, Janna L Huskey, Pooja Budhiraja, Tambi Jarmi, Aleksandra Kukla, Elena Beam
BACKGROUND: BK polyomavirus (BKV) infection is a common complication of kidney transplantation. While BKV has been described in non-kidney transplant recipients, data are limited regarding its epidemiology and outcomes in pancreas transplant recipients. METHODS: We conducted a retrospective cohort study of adults who underwent pancreas transplantation from 2010-2020. The primary outcome was BKV DNAemia. Secondary outcomes were estimated glomerular filtration rate (eGFR) reduction by 30%, eGFR < 30 mL/min/1...
September 13, 2023: Clinical Transplantation
https://read.qxmd.com/read/37536850/total-pancreatectomy-with-islet-auto-transplantation-surgical-procedure-outcomes-and-quality-of-life
#13
REVIEW
Melena D Bellin, Karthik Ramanathan, Srinath Chinnakotla
Chronic pancreatitis is a progressive and irreversible process of pancreatic inflammation and fibrosis that can lead to intractable abdominal pain and severely impaired quality of life (QoL). Often patients are refractory to standard medical or endoscopic treatments. Total pancreatectomy (TP) and islet auto-transplantation (TP-IAT) can offer pain relief to patients by removing the entire pancreas and the auto-transplant component ameliorates the resulting diabetes. QoL is significantly improved after TP-IAT when insulin independence is present...
September 2023: Advances in Surgery
https://read.qxmd.com/read/37388390/mortality-assessment-for-pancreas-transplants-in-the-united-states-over-the-decade-2008-2018
#14
JOURNAL ARTICLE
Tambi Jarmi, Emily Brennan, Jacob Clendenon, Aaron C Spaulding
BACKGROUND: Pancreas transplant is the only treatment that establishes normal glucose levels for patients diagnosed with diabetes. However, since 2005, no comprehensive analysis has compared survival outcomes of: (1) Simultaneous pancreas-kidney (SPK) transplant; (2) Pancreas after kidney (PAK) transplant; and (3) Pancreas transplant alone (PTA) to waitlist survival. AIM: To explore the outcomes of pancreas transplants in the United States during the decade 2008-2018...
June 18, 2023: World Journal of Transplantation
https://read.qxmd.com/read/37353238/youngest-pancreas-transplantation-alone-in-the-uk-for-type-1-diabetes-and-severe-subcutaneous-insulin-resistance
#15
JOURNAL ARTICLE
Garm Chi Ho, Sajanee Liz Samuel, Usman Haroon, Martin Drage
A child diagnosed with type 1 diabetes mellitus during her middle childhood developed severe subcutaneous insulin resistance as her illness progressed. This resulted in recurrent episodes of diabetic ketoacidosis and hypoglycaemia, eventually leading to intravenous insulin dependence. Despite intensive investigations, an organic cause was not found.The patient was in her late adolescence when she eventually received her pancreas transplant alone, the youngest patient in the UK. This case highlights severe peripheral insulin resistance as an important indication for whole organ pancreas transplantation in the paediatric population, as well as early recognition in the failure of conventional medical therapy...
June 23, 2023: BMJ Case Reports
https://read.qxmd.com/read/37266029/utilization-of-the-pancreas-from-donors-with-an-extremely-high-pancreas-donor-risk-index-report-of-the-national-registry-of-pancreas-transplantation
#16
JOURNAL ARTICLE
Keizo Kaku, Yasuhiro Okabe, Shinsuke Kubo, Yu Sato, Takanori Mei, Hiroshi Noguchi, Yoshito Tomimaru, Toshinori Ito, Takashi Kenmochi, Masafumi Nakamura
Pancreas transplants from expanded criteria donors are performed widely in Japan because there is a shortage of brain-dead donors. However, the effectiveness of this strategy is unknown. We retrospectively studied 371 pancreas transplants to evaluate the possibility of pancreas transplantation from expanded criteria donors by the Pancreas Donor Risk Index (PDRI). Patients were divided into five groups according to quintiles of PDRI values (Q1-Q5). The 1-year pancreas graft survival rates were 94.5% for Q1, 91...
2023: Transplant International
https://read.qxmd.com/read/37266028/metabolic-outcomes-after-pancreas-transplant-alone-from-donation-after-circulatory-death-donors-the-uk-transplant-registry-analysis
#17
JOURNAL ARTICLE
Jeevan Prakash Gopal, Adam McLean, Anand Muthusamy
Extrapolating data from early DCD (donation after circulatory death) kidney transplantation, pancreas transplants from DCD grafts were feared to have worse metabolic outcomes. Hence, we aimed to address the question of pancreas transplant alone (PTA) from DCD donors-are our concerns justified? A UK transplant registry analysis of 185 PTA performed between 2005 and 2018 was done. All early graft losses (<3 months) were excluded to allow focus on the metabolic outcomes (HbA1 c, weight gain and incidence of secondary diabetic macrovascular complications)...
2023: Transplant International
https://read.qxmd.com/read/37258778/pancreas-transplant-alone-in-the-usa-where-do-we-stand
#18
JOURNAL ARTICLE
Mahmoudreza Moein, Sarah Papa, Amin Bahreini, Reza Saidi
BACKGROUND: Currently, over 63,000 pancreas transplant procedures have been performed worldwide, with only approximately 8% of all pancreas transplants having been a pancreas transplant alone. Our study aimed to quantify outcomes following pancreas transplant alone in the United States from 2001 to 2020, with an emphasis on graft and patient survival. METHODS AND MATERIALS: We performed a retrospective registry analysis utilizing the OPTN/UNOS database for pancreas transplants alone performed in the United States from January 2001 to May 2020 to assess transplant outcomes...
May 31, 2023: World Journal of Surgery
https://read.qxmd.com/read/37132349/optn-srtr-2021-annual-data-report-pancreas
#19
JOURNAL ARTICLE
Raja Kandaswamy, Peter G Stock, Jonathan M Miller, Joann White, Sarah E Booker, Ajay K Israni, Jon J Snyder
The number of pancreas transplants in the United States was largely unchanged in 2021 at 963 transplants compared with 962 in 2020, showing that recovery from the COVID-19 pandemic was not as pronounced in pancreas transplantation as in other organs. The number of simultaneous pancreas-kidney transplants (SPKs) decreased from 827 to 820, whereas the number of pancreas-after-kidney transplants and pancreas transplants alone increased marginally to compensate. The proportion of patients with type 2 diabetes on the waiting list increased to 22...
February 2023: American Journal of Transplantation
https://read.qxmd.com/read/37113957/outcomes-of-pancreas-transplantation-in-patients-with-underlying-inflammatory-bowel-disease-a-retrospective-case-series
#20
JOURNAL ARTICLE
Samrat Ray, Anila Yousuf, Atit Dharia, Ghassan Ayoub, Catherine Parmentier, Andrea Norgate, Jeffrey Schiff, Chaya Shwaartz, Markus Selzner, Trevor W Reichman
UNLABELLED: Despite having emerged as a definitive treatment for diabetes mellitus (DM), pancreas transplantation remains a formidable surgical task owing to complications like graft pancreatitis, enteric leaks, and rejection. This becomes more challenging in the setting of underlying bowel pathology, such as inflammatory bowel disease (IBD), which has a strong immune-genomic association of co-existence with DM. Risk of anastomotic leaks, dose adjustments of immunosuppressants and biologicals, and management of IBD flares constitute some of the major perioperative challenges calling for a protocol-based, systematic, multidisciplinary approach...
April 2023: Annals of Medicine and Surgery
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