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Simultaneous pancreas kidney transplantation

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https://www.readbyqxmd.com/read/27895320/clinical-experience-with-pancreas-graft-rescue-from-severe-thrombus-after-simultaneous-pancreas-kidney-transplantation-by-early-detection-with-doppler-ultrasound-a-case-report
#1
Mitsunobu Takeda, Daisaku Yamada, Hidetoshi Eguchi, Tadafumi Asaoka, Takehiro Noda, Hiroshi Wada, Kunihito Goto, Koichi Kawamoto, Yutaka Takeda, Masahiro Tanemura, Toshinori Ito, Masaki Mori, Yuichiro Doki
BACKGROUND Graft thrombosis is the main cause of early graft loss after transplantation. In Japan, pancreases available for transplantation are frequently from marginal donors due to diverse backgrounds in the population. However, marginal tissues increase the risk of early thrombosis in the graft. CASE REPORT Here, we describe a 41-year-old woman with type 1 diabetes mellitus who underwent a simultaneous pancreas-kidney transplantation. The pancreas was retrieved from a 34-year-old man who had experienced severe hemodynamic instability...
November 29, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27888562/parainfluenza-3-infections-early-after-kidney-or-simultaneous-pancreas-kidney-transplantation
#2
Ilkka Helanterä, Veli-Jukka Anttila, Raisa Loginov, Marko Lempinen
Parainfluenza (PIV) can cause serious infections after hematopoietic stem cell or lung transplantation. Limited data exist about PIV infections after kidney transplantation. We describe an outbreak of PIV-3 in a transplant unit. During the outbreak 45 patients were treated on the ward for postoperative care after kidney or simultaneous pancreas-kidney (SPK) transplantation. Altogether 29 patients were tested for respiratory viruses (12 patients with respiratory symptoms, 17 asymptomatic exposed patients) from nasopharyngeal swabs with PCR...
November 26, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27864893/high-alcohol-intake-in-deceased-donors-has-no-effect-on-pancreas-graft-survival-a-registry-analysis
#3
R Motallebzadeh, M Aly, M El-Khairi, M Drage, J Olsburgh, C J Callaghan
Outcomes of pancreas transplantation from donors with high alcohol consumption are poorly described. The UK Transplant Registry was used to determine if donor alcohol intake influenced pancreas survival in simultaneous pancreas-kidney (SPK) transplants performed between 2006-2012 (n=770). Recipients were stratified by donor alcohol intake: group I (n=122) - high recent alcohol intake (>21 or >14 units of alcohol/week in males or females, respectively) or previous alcohol abuse; group II (n=648) - low/unknown current intake and no previous alcohol abuse...
November 19, 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/27801416/-evaluation-of-markers-for-renal-graft-dysfunction-in-patients-with-type-1-diabetes-mellitus-after-kidney-transplantation-and-simultaneous-pancreas-kidney-transplantation
#4
A M Glazunova, M S Arutyunova, E V Tarasov, L V Nikankina, A V Il'in, M Sh Shamkhalova, M V Shestakova, Ya G Moisyuk
AIM: To study the markers of renal graft dysfunction in patients with type 1 diabetes mellitus (T1DM) after kidney transplantation (KT) and simultaneous pancreas-kidney transplantation (SPKT). SUBJECTS AND METHODS: The investigation enrolled 20 patients after successful SPKT and 41 patients after KT (of them 21 received continuous subcutaneous insulin infusion with an insulin doser; 20 had multiple insulin injections). The periods after KT and SPKT at patient inclusion were 8 (7; 8) and 11 (8; 18) months, respectively...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/27798517/incidence-and-indications-for-late-allograft-pancreatectomy-while-on-continued-immunosuppression
#5
Sandesh Parajuli, Jon Odorico, Brad C Astor, Arjang Djamali, Hans Sollinger, Robert Redfield, Dixon Kaufman, Didier A Mandelbrot
BACKGROUND: There are limited data about the incidence and indications for late allograft pancreatectomy while on continued immunosuppression for functional kidney allografts. METHODS: We analyzed recipients of simultaneous pancreas and kidney (SPK) and pancreas after kidney (PAK) transplants between January 1994 and July 2013. Patients with functional kidney but failed pancreas allografts after 90 days were included. RESULTS: Out of 1022 SPK or PAK recipients, 246 satisfied these criteria...
October 28, 2016: Transplantation
https://www.readbyqxmd.com/read/27742347/acetylsalicylic-acid-resistance-after-simultaneous-pancreas-kidney-transplantation
#6
D Praksch, B Sandor, K K Nagy, M Viola, A Toth, K Toth, P Szakaly, A Varga
BACKGROUND: The most common conditions leading to death after simultaneous pancreas-kidney transplantations (SPKs) are cardiovascular diseases. The aim of this study was to test the platelet aggregation inhibitor acetylsalicylic acid (ASA) resistance in patients after SPKs, including investigations into the triggering factors. METHODS: Thirty-two patients (22 men, 10 women; overall age, 47.4 ± 8.6 years) were involved in our study and took 100 mg ASA per day. We used optical platelet aggregometry to detect resistance...
September 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27742285/invasive-fungal-disease-in-renal-transplant-recipients-at-a-brazilian-center-local-epidemiology-matters
#7
L F A Guimarães, M Halpern, A S de Lemos, E F de Gouvêa, R T Gonçalves, M A A da Rosa Santos, M Nucci, G Santoro-Lopes
INTRODUCTION: Invasive fungal disease (IFD) is an important complication after solid organ transplantation (SOT). A marked geographic variation in the epidemiology of IFD after kidney transplantation (KT) has been suggested by the results of previous studies. Nevertheless, data from Latin American centers are scarce. OBJECTIVE: This study sought to describe the epidemiology of IFD at a Brazilian KT center. METHODS: This study was a retrospective single-center cohort study that included patients who underwent KT between 1998 and 2009 and were followed up until July 2015...
September 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27720628/-simultaneous-pancreas-and-kidney-transplantation
#8
L Badet, X Matillon, R Codas, J Branchereau, G Karam, M-O Timsit, R Thuret, F Kleinclauss
OBJECTIVES: To perform a State of The Art about the different aspects of pancreas transplantation such as indications, technical features, immunosuppressive strategies and outcomes of simultaneous pancreas-kidney transplantation. MATERIAL AND METHODS: An exhaustive systematic review of the scientific literature was performed in the Medline database (http://www.ncbi.nlm.nih.gov) and Embase (http://www.embase.com) using different associations of the following keywords (MESH) : « pancreas transplantation; kidney transplantation; simultaneous pancreas-kidney transplantation; immunosuppression »...
October 6, 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27716570/ectopic-pregnancy-in-simultaneous-pancreas-kidney-transplantation-a-case-report
#9
Shinji Yamamoto, Maria Nelander
INTRODUCTION: We present a case report of ectopic pregnancy (EP) after simultaneous pancreas-kidney transplantation (SKPTx). PRESENTATION OF CASE: A 33-year-old female status post SKPTx suddenly got abdominal pain in the lower level. She had high human chorionic Gonadotropin test. Ultrasonography revealed that there was no fetus in the uterus but a dilated right fallopian tube, which strongly suggested ectopic pregnancy. An emergency operation was performed and a dilated right side uterine tube was found with adhesions to her transplant...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27692005/impact-of-an-infection-control-and-antimicrobial-stewardship-program-on-solid-organ-transplantation-and-hepatobiliary-surgical-site-infections
#10
Charles Frenette, David Sperlea, Yveta Leharova, Daniel J G Thirion
OBJECTIVE The goal of this long-term quasi-experimental retrospective study was to assess the impact of a 5-year serial infection control and antimicrobial stewardship intervention on surgical site infections (SSIs). METHODS This study was conducted in a tertiary-care public teaching institution over a 5-year period from January 2010 to December 2014. All patients undergoing hepatobiliary surgery and liver, kidney, pancreas, and simultaneous pancreas-kidney transplantation were included. Outcomes were compared between a preintervention group (2010-2011) and a postintervention group (2012-2014)...
December 2016: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/27590562/donor-derived-strongyloides-stercoralis-hyperinfection-syndrome-after-simultaneous-kidney-pancreas-transplantation
#11
A Galiano, M Trelis, Á Moya-Herráiz, J Sánchez-Plumed, J F Merino
Most cases of strongyloidiasis associated with solid organ transplantation have been due to the reactivation of a latent infection in the recipient as a result of the immunosuppressive therapy; however, donor-derived infections are becoming increasingly frequent. The case of a patient who nearly died of a Strongyloides stercoralis hyperinfection after receiving simultaneous kidney/pancreas transplants is described herein. No specific parasitological tests were performed pre-transplantation, despite the fact that both the recipient and the donor originated from endemic areas...
August 30, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27515042/multiorgan-transplantation
#12
REVIEW
Erik Stites, Alexander C Wiseman
Kidney transplantation has proven to be the gold standard therapy for severe chronic kidney disease (CKD) due to multiple etiologies in individuals deemed eligible from a surgical standpoint. While kidney transplantation is traditionally considered in conditions of native kidney disease such as diabetes and immunological or inherited causes of kidney disease, an increasing indication for kidney transplantation is kidney dysfunction in the setting of other severe organ dysfunction that requires transplant, such as severe liver or heart disease...
October 2016: Transplantation Reviews
https://www.readbyqxmd.com/read/27500244/conservative-pancreas-graft-preservation-at-the-extreme
#13
Jerome Martin Laurence, Gonzalo Sapisochin, Markus Selzner, Andrea Norgate, Deepali Kumar, Ian D McGilvary, Paul D Preig, Jeffrey Schiff, Mark S Cattral
Because of the value some patients place in remaining insulin-independent after pancreas transplantation, they may be reluctant to undergo graft pancreatectomy, even in the face of extreme complications, such as graft thrombosis and duodenal segment leak. Partly, for this reason, a variety of complex salvage techniques have been described to save the graft in such circumstances. We report a case of a series of extreme complications related to a leak from the duodenal segment after a simultaneous pancreas and kidney transplant...
January 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27496471/long-term-outcomes-of-kidney-and-simultaneous-pancreas-kidney-transplantation-in-recipients-with-type-1-diabetes-mellitus-silesian-experience
#14
J Ziaja, A Kolonko, D Kamińska, J Chudek, A J Owczarek, A Kujawa-Szewieczek, M Kuriata-Kordek, K Krzyżowska, J Badura, J Czerwiński, E Jęrdusik, R Król, M Klinger, A Więcek, L Cierpka
BACKGROUND: Kidney transplantation (KTx) markedly reduces mortality in patients with end-stage kidney disease (ESKD) caused by type 1 diabetes mellitus (T1DM). The outstanding issue is whether transplantation should be limited only to KTx, with further insulinotherapy, or combined with pancreas transplantation in patients with ESKD/T1DM. The goal of this study was to compare the results of simultaneous pancreas-kidney transplantation (SPKTx) and deceased donor KTx and to identify factors affecting patient and kidney graft survival in patients with ESKD/T1DM...
June 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27496470/usefulness-of-modified-dindo-clavien-scale-to-evaluate-the-correlation-between-the-severity-of-surgical-complications-and-complications-related-to-the-renal-and-pancreatic-grafts-after-simultaneous-kidney-and-pancreas-transplantation
#15
T Grochowiecki, K Madej, Z Gałązka, T Jakimowicz, M Jędrasik, P Świercz, K Łukawski, L Pączek, M Durlik, S Nazarewski, J Szmidt
OBJECTIVE: Simultaneous pancreas and kidney transplantation (spktx) is the multiorgan transplantation. Thus various complications originated from transplanted organs and the complications that are not directly related to pancreatic or renal grafts could be developed at the same recipient. AIM: The aim of this study is to explore whether there is a correlation between the severity of complications originated from transplanted pancreas, transplanted kidney and general surgical complication developed at the same spktx recipient...
June 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27496469/surgical-complications-not-related-to-the-renal-and-pancreatic-grafts-after-simultaneous-kidney-and-pancreas-transplantation
#16
T Grochowiecki, K Madej, Z Gałązka, T Jakimowicz, M Jędrasik, K Grygiel, L Pączek, M Durlik, S Nazarewski, J Szmidt
BACKGROUND: Simultaneous pancreas and kidney transplantation (SPKTx) is the most commonly performed multiorgan transplantation procedure worldwide. Transplanted organs are the main source of complication; however, some postoperative complications are not directly related to the pancreatic or renal grafts. The goal of this study was to evaluate the prevalence, type, and severity of postoperative complications not related to transplanted kidney or pancreas among SPKTx recipients. METHODS: Complications unrelated to transplanted pancreas and kidneys among 112 SPKTx recipients were analyzed...
June 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27496468/past-cardiovascular-episodes-deteriorate-quality-of-life-of-patients-with-type-1-diabetes-and-end-stage-kidney-disease-after-kidney-or-simultaneous-pancreas-and-kidney-transplantation
#17
D Bożek-Pająk, J Ziaja, A Kowalik, M Farnik, A Kolonko, A Kujawa-Szewieczek, D Kamińska, M Kuriata-Kordek, R Król, A Więcek, M Klinger, L Cierpka
BACKGROUND: The beneficial influence of kidney (KTx) or simultaneous pancreas and kidney transplantation (SPK) on quality of life (QOL) in patients with end-stage kidney disease caused by type 1 diabetes mellitus was confirmed in many studies. The aim of this study was to identify factors that influence QOL of patients in long-term follow-up after SPK or KTx. METHODS: Twenty-seven SPK and 26 KTx patients with good function of transplanted organs at least 1 year after transplantation were enrolled into the analysis...
June 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27489970/charcot-s-neuroarthropathy-after-simultaneous-pancreas-kidney-transplanta-case-report
#18
Michael Wilson
Simultaneous pancreas-kidney transplant (SPKT) is an accepted approach and the treatment of choice in patients with type 1 diabetes with accompanying end-stage renal disease. Charcot's neuroarthropathy of the foot (CN) is a fairly common and devastating complication found in patients with long-standing, mostly uncontrolled, diabetes. However, CN has also been identified as a posttransplant consequence of SPKT. Traditional postoperative immunosuppressive therapy, particularly the use of corticosteroids, is acknowledged as an additional risk factor for the development of de novo CN after SPKT...
July 2016: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/27484276/an-ethical-dilemma-malignant-melanoma-in-a-51-year-old-patient-awaiting-simultaneous-kidney-and-pancreas-transplantation-for-type-1-diabetes
#19
L C Kirby, A Banerjee, T Augustine, J F Douglas
Malignant melanoma is a high-risk skin cancer that, in potential transplant recipients, is considered a substantial contraindication to solid organ transplantation due to significant risk of recurrence with immunosuppression. Current guidelines stipulate waiting between 3 and 10 years after melanoma diagnosis. However, in young patients with end-stage organ failure and malignant melanoma, complex ethical and moral issues arise. Assessment of the true risk associated with transplantation in these patients is difficult due to lack of prospective data, but an autonomous patient can make a decision that clinicians may perceive to be high risk...
July 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27467687/cardiac-assessment-of-patients-with-type-1-diabetes-median-10-years-after-successful-simultaneous-pancreas-and-kidney-transplantation-compared-with-living-donor-kidney-transplantation
#20
Jørn Petter Lindahl, Richard John Massey, Anders Hartmann, Svend Aakhus, Knut Endresen, Anne Günther, Karsten Midtvedt, Hallvard Holdaas, Torbjørn Leivestad, Rune Horneland, Ole Øyen, Trond Jenssen
BACKGROUND: In recipients with type 1 diabetes, we aimed to determine whether long-term normoglycemia achieved by successful simultaneous pancreas and kidney (SPK) transplantation could beneficially affect progression of coronary artery disease (CAD) when compared with transplantation of a kidney-alone from a living donor (LDK). METHODS: In 42 kidney transplant recipients with functioning grafts who had received either SPK (n = 25) or LDK (n = 17), we studied angiographic progression of CAD between baseline (pretransplant) and follow-up at 7 years or older...
June 1, 2016: Transplantation
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