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JOURNAL ARTICLE
Sandy Feng, Garrett R Roll, Foad J Rouhani, Alberto Sanchez Fueyo
Over the last 50 years, liver transplantation has evolved into a procedure routinely performed in many countries worldwide. Those able to access this therapy frequently experience a miraculous risk-benefit ratio since, particularly if they face imminently life threatening disease. Over the decades, the success of liver transplantation, with dramatic improvements in early post-transplant survival, has aggressively driven demand. However, in spite of the emergence of living donors to augment deceased donors as a source of organs, supply has lagged far behind demand...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
#22
Usman Iqbal Aujla, Imran Ali Syed, Ahmad Karim Malik, Muhammad Ramzan, Abdullah Saeed
Post-liver transplantation biliary complications remain a serious concern and are associated with reduced patient and graft survival. Among various biliary complications, anastomotic stricture (AS) is the most frequent and challenging one. The frequency of AS after living donor liver transplantation (LDLT) is higher as compared to deceased donor liver transplantation. The management involves endoscopic retrograde cholangiopancreatography and/or percutaneous transhepatic biliary drainage, but refractory cases necessitate surgical revision...
March 2024: ACG Case Reports Journal
#23
JOURNAL ARTICLE
Weili Wang, Yangyang Wang, Yuntao Zhang, Wei Zhang, Xueli Bai, Qi Zhang, Tingbo Liang
BACKGROUND: Fungal bloodstream infection (fBSI) following pediatric liver transplantation present a significant challenge; however, there remains a paucity of guidance regarding antifungal prophylaxis in this population. This study aimed to evaluate the effectiveness of universal antifungal prophylaxis and propose a desirable strategy. METHODS: We enrolled 604 pediatric patients who underwent liver transplantation between 2020 and 2023, including 242 patients with empirical prophylaxis and 362 patients with universal prophylaxis...
March 21, 2024: International Journal of Infectious Diseases: IJID
#24
JOURNAL ARTICLE
Elisa Allen, Rhiannon Taylor, Alex Ander Gimson, Douglas Thorburn, Dave Collett, Elisa Allen, Varuna Aluvihare, Alex Gimson, Ernest Hidalgo, John O'Grady, Tahir Shah, Doug Thorburn, John Crookenden, Alastair MacGilchrist, James O'Beirne, James Powel, Martine Walmsley
BACKGROUND & AIMS: The National Liver Offering Scheme (NLOS) was introduced in the UK in 2018 to offer livers from deceased donors to patients on the national waiting list based, for most patients, on calculated transplant benefit. Before NLOS, livers were offered to transplant centres by geographic donor zones and, within centres, by estimated recipient need for a transplant. METHODS: UK Transplant Registry data on patient registrations and transplants were analysed to build survival on the list (M1) and survival post-transplantation (M2) statistical models...
March 21, 2024: Journal of Hepatology
#25
JOURNAL ARTICLE
Akira Umemura, Hiroyuki Nitta, Daiki Takeda, Hirokatsu Katagiri, Shoji Kanno, Akira Sasaki
BACKGROUND: The transthoracic transdiaphragmatic approach (TTA) for hepatic tumors in laparoscopic liver resection (LLR) is not usually employed because the caudal approach via the abdominal cavity is the gold standard in LLRs. Here, we present a case of LLR via TTA for hepatocellular carcinoma (HCC) in a patient with severe obesity and a history of deceased donor liver transplantation (DDLT). MATERIALS AND SURGICAL TECHNIQUE: The patient, a 64-year-old man with severe obesity and a history of DDLT, was referred to our hospital to undergo LLR for HCC located at the cranial side of segment IV...
April 2024: Asian Journal of Endoscopic Surgery
#26
JOURNAL ARTICLE
Chase J Wehrle, Marianna Maspero, Antonio D Pinna, Philipp Dutkowski, Charles Miller, Koji Hashimoto, Pierre-Alain Clavien, Andrea Schlegel
OBJECTIVE: Assess factors affecting the cumulative lifespan of a transplanted liver. SUMMARY BACKGROUND DATA: Liver ageing is different from other solid organs. It is unknown how old a liver can actually get after liver transplantation (LT). METHODS: Deceased donor liver transplants from 1988-2021 were queried from the United States (US) UNOS registry. Cumulative liver age was calculated as donor age + recipient graft survival. RESULTS: In total, 184,515 livers were included...
March 11, 2024: Annals of Surgery
#27
JOURNAL ARTICLE
Jongman Kim, Jae-Won Joh, Kwang-Woong Lee, Dong Lak Choi, Hee-Jung Wang
BACKGROUNDS/AIMS: Prolonged use of steroids after liver transplantation (LT) significantly increases the risk of diabetes or cardiovascular disease, which can adversely affect patient outcomes. Our study evaluated the effectiveness and safety of early steroid withdrawal within the first year following LT. METHODS: This study was conducted as an open-label, multicenter, randomized controlled trial. Liver transplant recipients were randomly assigned to one of the following two groups: Group 1, in which steroids were withdrawn two weeks posttransplantation, and Group 2, in which steroids were withdrawn three months posttransplantation...
March 15, 2024: Annals of Hepato-Biliary-Pancreatic Surgery
#28
JOURNAL ARTICLE
Jenna N Whitrock, Catherine G Pratt, Shimul A Shah
PURPOSE OF REVIEW: While liver transplant for unresectable colorectal cancer liver metastases (CRLM) has been demonstrated to be a promising treatment in selected patients, the typically low MELD score of these patients and lack of exception points may lead to challenges in receiving a deceased donor liver for transplant. RECENT FINDINGS: Several studies have shown improved outcomes in select patients with CRLM who undergo liver transplant, and several trials are ongoing and will conclude in the next several years...
March 15, 2024: Current Opinion in Organ Transplantation
#29
JOURNAL ARTICLE
William Cruz Mususú, Andrea García-Lopez, Nicolás Lozano-Suarez, Andrea Gómez-Montero, Milena Orellano-Salas, Luisa Vargas-Pérez, Ximena Escobar-Chaves, Fernando Girón-Luque
OBJECTIVE: To obtain a comprehensive overview of organ donation, organ utilization, and discard in the entire donation process in Colombia. METHODS: A retrospective study of 1 451 possible donors, distributed in three regions of Colombia, evaluated in 2022. The general characteristics, diagnosis, and causes of contraindication for potential donors were described. RESULTS: Among the 1 451 possible donors, 441 (30.4%) fulfilled brain death criteria, constituting the potential dono r pool...
2024: Pan American Journal of Public Health
#30
JOURNAL ARTICLE
Ashton A Connor, Max W Adelman, Constance M Mobley, Mozhgon Moaddab, Alexandra J Erhardt, David E Hsu, Elizabeth W Brombosz, Mansi Sanghvi, Yee Lee Cheah, Caroline J Simon, Mark J Hobeika, Ashish S Saharia, David W Victor, Sudha Kodali, Tamneet Basra, Edward A Graviss, Duc T Nguyen, Ahmed Elsaiey, Linda W Moore, Masayuki Nigo, Ashley L Drews, Kevin A Grimes, Cesar A Arias, Xian C Li, A Osama Gaber, R Mark Ghobrial
BACKGROUND: The COVID-19 pandemic has led to an increase in SARS-CoV-2-test positive potential organ donors. The benefits of life-saving liver transplantation (LT) must be balanced against the potential risk of donor-derived viral transmission. Although emerging evidence suggests that the use of COVID-19-positive donor organs may be safe, granular series thoroughly evaluating safety are still needed. Results of 29 consecutive LTs from COVID-19-positive donors at a single center are presented here...
April 2024: Transplantation Direct
#31
Bernardo Canhão, Augusta Cipriano, Armando Carvalho, Adélia Simão, João Madaleno
In Western countries, deceased donor liver transplantation remains the standard of care for patients with end-stage liver disease. Living donor liver transplantation is a viable and feasible strategy for patients with end-stage liver disease designed to mitigate the deceased organ shortage. Donor safety is the primary concern because liver donors, ideally, should not have any complication. We report a case of middle-aged woman without a history of chronic liver disease who developed autoimmune hepatitis more than 20 years after live liver donation...
March 2024: ACG Case Reports Journal
#32
JOURNAL ARTICLE
Chia-En Hsieh, Ya-Lan Hsu, Yao-Li Chen, Hsin-Rou Liang, Kuo-Hua Lin, Wen-Yuan Chen, Hsiu-Man Wu, Sin-Bao Hunang, Yu-Ju Hung
AIMS: The use of extended criteria donors is a routine practice that sometimes involves extracorporeal membrane oxygenation (ECMO) in donations after cardiac death or brain death. METHODS: We performed a retrospective study in a single center from January 2006 to December 2019. The study included 90 deceased donor liver transplants. The patients were divided into three groups: the donation after brain death (DBD) group ( n = 58, 64.4%), the DBD with ECMO group ( n = 11, 12...
March 2024: Annals of Gastroenterological Surgery
#33
JOURNAL ARTICLE
Jennifer D Motter, Ian S Jaffe, Nader Moazami, Deane E Smith, Zachary N Kon, Greta L Piper, Philip M Sommer, Alex Reyentovich, Stephanie H Chang, Imad Aljabban, Robert A Montgomery, Dorry L Segev, Allan B Massie, Bonnie E Lonze
INTRODUCTION: Thoracoabdominal normothermic regional perfusion (TA-NRP) following cardiac death is an emerging multivisceral organ procurement technique. Recent national studies on outcomes of presumptive TA-NRP-procured organs are limited by potential misclassification since TA-NRP is not differentiated from donation after cardiac death (DCD) in registry data. METHODS: We studied 22 donors whose designees consented to TA-NRP and organ procurement performed at our institution between January 20, 2020 and July 3, 2022...
March 2024: Clinical Transplantation
#34
JOURNAL ARTICLE
Elizabeth A Wilson, Devin L Weinberg, Gaurav P Patel
Orthotopic liver transplantation (OLT) is the most effective treatment for patients with end-stage liver disease (ESLD). Hepatic insufficiency within a week of OLT, termed early allograft dysfunction (EAD), occurs in 20% to 25% of deceased donor OLT recipients and is associated with morbidity and mortality. Primary nonfunction (PNF), the most severe form of EAD, leads to death or retransplantation within 7 days. The etiology of EAD is multifactorial, including donor, recipient, and surgery-related factors, and largely driven by ischemia-reperfusion injury (IRI)...
March 5, 2024: Anesthesia and Analgesia
#35
JOURNAL ARTICLE
Ajay K Israni, David A Zaun, Katrina Gauntt, Cory R Schaffhausen, Cinthia Lozano, Warren T McKinney, Jonathan M Miller, Jon J Snyder
The Scientific Registry of Transplant Recipients uses data collected by the Organ Procurement and Transplantation Network to calculate metrics such as organs recovered per donor, organs transplanted per donor, and organs recovered for transplant but not transplanted (ie, nonuse). In 2022, there were 14,905 deceased donors, a 7.5% increase from 13,863 in 2021, and this number has been increasing since 2010. The number of deceased donor organs used for transplant increased to 37,334 in 2022, a 4.6% increase from 35,687 in 2021; this number has been increasing since 2012...
February 2024: American Journal of Transplantation
#36
JOURNAL ARTICLE
Allison J Kwong, W Ray Kim, John R Lake, David P Schladt, Erin M Schnellinger, Katrina Gauntt, Meghan McDermott, Samantha Weiss, Dzhuliyana K Handarova, Jon J Snyder, Ajay K Israni
In 2022, liver transplant activity continued to increase in the United States, with an all-time high of 9,527 transplants performed, representing a 52% increase over the past decade (2012-2022). Of these transplants, 8,924 (93.7%) were from deceased donors and 603 (6.3%) were from living donors. Liver transplant recipients were 94.5% adult and 5.5% pediatric. The overall size of the liver transplant waiting list contracted, with more patients being removed than added, although 10,548 adult patients still remained on the waiting list at the end of 2022...
February 2024: American Journal of Transplantation
#37
JOURNAL ARTICLE
David P Schladt, Ajay K Israni
The OPTN/SRTR 2022 Annual Data Report presents the status of the solid organ transplant system in the United States from 2011 through 2022. Organ-specific chapters are presented for kidney, pancreas, liver, intestine, heart, and lung transplant. Each organ-specific chapter is organized to present waitlist information, donor information (both deceased and living, as appropriate), transplant information, and patient outcomes. Data pertaining to pediatric patients are generally presented separately from the adult data...
February 2024: American Journal of Transplantation
#38
REVIEW
Haytham Maria, Pamela L Valentino, Patrick J Healey, Yong K Kwon
BACKGROUND: Small-for-size syndrome (SFSS) in pediatric liver transplant recipients, particularly those weighing less than 10 kg, is rare. This report describes a case of a 15-month-old whole liver transplant recipient who suffered SFSS, and systematic literature review was performed to identify outcomes of such cases and potential risk factors for SFSS. CASE PRESENTATION: A 15-month-old toddler with a history of biliary atresia underwent a deceased donor whole liver transplant...
March 2024: Pediatric Transplantation
#39
EDITORIAL
Dong-Sik Kim, Young-In Yoon, Beom Kyung Kim, Ashok Choudhury, Anand Kulkarni, Jun Yong Park, Jongman Kim, Dong Hyun Sinn, Dong Jin Joo, YoungRok Choi, Jeong-Hoon Lee, Ho Joong Choi, Ki Tae Yoon, Sun Young Yim, Cheon-Soo Park, Deok-Gie Kim, Hae Won Lee, Won-Mook Choi, Young Eun Chon, Woo-Hyoung Kang, Jinsoo Rhu, Jae Geun Lee, Yuri Cho, Pil Soo Sung, Han Ah Lee, Ji Hoon Kim, Si Hyun Bae, Jin Mo Yang, Kyung-Suk Suh, Mamun Al Mahtab, Soek Siam Tan, Zaigham Abbas, Ananta Shresta, Shahinul Alam, Anil Arora, Ashish Kumar, Pravin Rathi, Ruveena Bhavani, Charles Panackel, Kuei Chuan Lee, Jun Li, Ming-Lung Yu, Jacob George, Tawesak Tanwandee, Sen-Yung Hsieh, Chee Chien Yong, Mohamed Rela, H C Lin, Masao Omata, Shiv Kumar Sarin
Liver transplantation is a highly complex and challenging field of clinical practice. Although it was originally developed in western countries, it has been further advanced in Asian countries through the use of living donor liver transplantation. This method of transplantation is the only available option in many countries in the Asia-Pacific region due to the lack of deceased organ donation. As a result of this clinical situation, there is a growing need for guidelines that are specific to the Asia-Pacific region...
February 28, 2024: Hepatology International
#40
JOURNAL ARTICLE
João Seda Neto, Carolina M Costa, Renata Pugliese, Rodrigo Vincenzi, Marcel R Benavides, Nathália P R Travassos, Caio M V de Oliveira, Karina Roda, Debora P Fernandes, Mário Kondo, Eduardo A Fonseca
BACKGROUND: Currently, graft options for pediatric liver transplantation (PLT) include whole (WL) and partial (P) grafts, in the form of either deceased donor transplantation (DD) or living donor liver transplantation (LD). WL transplants from LD are commonly referred to as domino LT. The objective of this manuscript is to compare the outcomes of PLT performed with each of the available graft options. METHODS: Retrospective cohort study from Jan. 2010 to Dec. 2022...
February 19, 2024: Journal of Pediatric Surgery
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