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subarachnoid hemorrhage 

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https://www.readbyqxmd.com/read/28342923/giant-intracranial-aneurysms-surgical-treatment-and-risk-factors-analysis
#1
Long Xu, Xiaofeng Deng, Shuo Wang, Yong Cao, Yuanli Zhao, Dong Zhang, Yan Zhang, Rong Wang, Wei Qi, Jizong Zhao
OBJECTIVE: The surgical treatment of giant intracranial aneurysms (GIAs; diameter≥25mm) is challenging. The objective of this paper is to study the clinical outcome of GIAs treated with different surgical modalities and to analyze the factors affecting prognosis. METHODS: A consecutive series of 204 patients with GIAs who received surgical treatment in our department from 1995 to 2008 were analyzed retrospectively. The clinical outcome was evaluated with the Glasgow Outcome Scale (GOS)...
March 22, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28342702/apigenin-attenuates-oxidative-stress-and-neuronal-apoptosis-in-early-brain-injury-following-subarachnoid-hemorrhage
#2
Yuwei Han, Tingting Zhang, Jingyuan Su, Yuan Zhao, Chenchen, Wang, Xiaoming Li
Apigenin (API) is a naturally occurring plant flavone that exhibits powerful antioxidant and antiapoptosis. Oxidative stress plays an important role in the pathogenesis of early brain injury (EBI) following subarachnoid hemorrhage (SAH). The potential anti-oxidative and anti-apoptosis effects of API on EBI following SAH, however, have not been elucidated. The aim of this study was to assess whether API alleviates EBI after SAH via its anti-oxidative and anti-apoptotic effects. The endovascular puncture model was used to induce SAH and all the rats were subsequently sacrificed at 24h after SAH...
March 22, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28342700/nicotine-replacement-therapy-in-patients-with-aneurysmal-subarachnoid-hemorrhage-systematic-review-of-the-literature-and-survey-of-canadian-practice
#3
REVIEW
Ricky D Turgeon, Stephano J Chang, Charlotte Dandurand, Peter A Gooderham, Camille Hunt
Tobacco smoke increases the risk of aneurysmal subarachnoid hemorrhage (SAH), as well as complications such as vasospasm. Most patients presenting with aneurysmal SAH smoke, and many survivors continue to smoke after discharge. Neurosurgeons often hesitate to use nicotine replacement therapy (NRT) during hospitalization of patients with SAH due to concerns of inducing vasospasm. We aimed to evaluate the safety and efficacy, and patterns of use of NRT in smokers hospitalized for SAH. We performed a systematic review of MEDLINE, CENTRAL, Embase, and unpublished sources of literature to October 2016 for randomized and observational studies comparing exposure to non-exposure of smoking cessation products in the acute phase of aneurysmal SAH...
March 22, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28342655/tacrolimus-induced-reversible-cerebral-vasoconstriction-syndrome-with-delayed-multi-segmental-vasoconstriction
#4
Satoshi Kodama, Tatsuo Mano, Akihiro Masuzawa, Yasutaka Hirata, Yuki Nagasako, Kagari Koshi Mano, Masashi Hamada, Yasuo Terao, Toshihiro Hayashi, Minoru Ono, Shoji Tsuji
Reversible cerebral vasoconstriction syndrome (RCVS) is a cerebrovascular syndrome characterized by multi-segmental constrictions of the cerebral arteries that resolves spontaneously within 3 months. Although RCVS is considered to be due to transient dysregulation of vascular tone, the exact pathomechanism remains unclear. We describe the case of a 15-year-old girl with RCVS induced by tacrolimus, who developed generalized seizure during the postoperative course of orthotropic heart transplantation. Magnetic resonance imaging at symptom onset showed a few vasoconstrictions accompanying brain edema and convexity subarachnoid hemorrhage...
March 22, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28339483/temporal-evolution-of-vasospasm-and-clinical-outcome-after-intra-arterial-vasodilator-therapy-in-patients-with-aneurysmal-subarachnoid-hemorrhage
#5
Laleh Daftari Besheli, Can Ozan Tan, Donnie L Bell, Joshua A Hirsch, Rajiv Gupta
Intra-arterial (IA) vasodilator therapy is one of the recommended treatments to minimize the impact of aneurysmal subarachnoid hemorrhage-induced cerebral vasospasm refractory to standard management. However, its usefulness and efficacy is not well established. We evaluated the effect IA vasodilator therapy on middle cerebral artery blood flow and on discharge outcome. We reviewed records for 115 adults admitted to Neurointensive Care Unit to test whether there was a difference in clinical outcome (discharge mRS) in those who received IA infusions...
2017: PloS One
https://www.readbyqxmd.com/read/28337226/tetramethylpyrazine-protects-against-early-brain-injury-after-experimental-subarachnoid-hemorrhage-by-affecting-mitochondrial-dependent-caspase-3-apoptotic-pathway
#6
Shaoxue Li, Xiaolan Xiao, Xiaojia Ni, Zhennan Ye, Junjie Zhao, Chunhua Hang
This study was to test the hypothesis that tetramethylpyrazine (TMP) protected against early brain injury after subarachnoid hemorrhage (SAH) by affecting the mitochondrial-dependent caspase-3 apoptotic pathway. TMP was administrated after the rats' prechiasmatic SAH mode. Animal neurobehavioral functions were assessed and the mitochondrial morphology, mitochondrial and cytoplasmic calcium, and mitochondrial membrane potential changes (Δψm) of the brain tissues were measured. The expressions of cytoplasmic cytochrome c (cyt c), second mitochondria-derived activator of caspases (Smac), and cleaved caspase-3 B-cell lymphoma 2 (bcl-2) in cells were determined and cellular apoptosis was detected...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28335661/safety-and-efficacy-of-balloon-angioplasty-of-the-anterior-cerebral-artery-for-vasospasm-treatment-after-subarachnoid-hemorrhage
#7
Nauman S Chaudhry, Jennifer L Orning, Sophia F Shakur, Sepideh Amin-Hanjani, Victor A Aletich, Fady T Charbel, Ali Alaraj
Balloon angioplasty is often performed for symptomatic vasospasm following aneurysmal subarachnoid hemorrhage. Angioplasty of the anterior cerebral artery (ACA), however, is perceived to be a challenging endeavor and not routinely performed due to technical and safety concerns. Here, we evaluate the safety and efficacy of balloon angioplasty of the anterior cerebral artery for vasospasm treatment. Patients with vasospasm following subarachnoid hemorrhage who underwent balloon angioplasty at our institution between 2011 and 2016 were retrospectively reviewed...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/28333777/arteriovenous-lesions-of-the-internal-auditory-canal
#8
Charles L Anzalone, John I Lane, Michael J Link, Matthew L Carlson
OBJECTIVE: To describe a unique case of an asymptomatic arteriovenous lesion of the internal auditory canal (IAC) and present the associated imaging findings. METHODS: Retrospective case report and review of the literature. RESULTS: A 55-year-old man presented for further evaluation of a left-sided sudden sensorineural hearing loss that occurred 8 years earlier. Careful review of outside serial magnetic resonance (MR) imaging revealed a contralateral, ill-defined right-sided IAC mass with low T2 signal and subtle peripheral enhancement on postcontrast T1-weighted sequencing...
March 22, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28331261/bilateral-traumatic-intracranial-hematomas-and-its-outcome-a-retrospective-study
#9
Sharad Pandey, Vivek Sharma, Kulwant Singh, Deepa Pandey, Mukesh Sharma, Deepak Bhanudas Patil, Neeraj Shende, Richa Singh Chauhan
The objective of this study was to evaluate the age distribution, mode of injury, type of hematomas, and their surgical outcome in patients with bilateral traumatic head injuries. The present study included 669 cases of traumatic head injury who presented at the neurosurgery emergency out of which 94 cases had bilateral head injuries from the period of August 2009 to April 2014. The data from the hospital computerized database were retrospectively analysed. Cases of bilateral traumatic head injury included 94 patients out of which 88...
February 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/28330942/primary-angiitis-of-the-central-nervous-system-magnetic-resonance-imaging-spectrum-of-parenchymal-meningeal-and-vascular-lesions-at-baseline
#10
Grégoire Boulouis, Hubert de Boysson, Mathieu Zuber, Loïc Guillevin, Eric Meary, Vincent Costalat, Christian Pagnoux, Olivier Naggara
BACKGROUND AND PURPOSE: Primary angiitis of the central nervous system remains challenging. To report an overview and pictorial review of brain magnetic resonance imaging findings in adult primary angiitis of the central nervous system and to determine the distribution of parenchymal, meningeal, and vascular lesions in a large multicentric cohort. METHODS: Adult patients from the French COVAC cohort (Cohort of Patients With Primary Vasculitis of the Central Nervous System), with biopsy or angiographically proven primary angiitis of the central nervous system and brain magnetic resonance imaging available at the time of diagnosis were included...
March 22, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28330417/involvement-of-nox2-and-nox4-nadph-oxidases-in-early-brain-injury-after-subarachnoid-hemorrhage
#11
Li Zhang, Zhen Li, Dongxia Feng, Haitao Shen, Xiaodi Tian, Haiying Li, Zhong Wang, Gang Chen
Oxidative stress is responsible for a poor prognosis of subarachnoid hemorrhage (SAH) patients. Nox2 has been shown to participate in SAH-induced early brain injury (EBI). Nox4 is another major subtype of Nox family widely expressed in CNS. Here, we investigated the role of Nox4 and whether there was a synergistic effect of Nox2 and Nox4 in SAH-induced EBI. Clinical brain biopsies of four patients with traumatic brain injury and perihematomal brain tissue from six subjects with SAH were examined. Gp91ds-tat (a specific inhibitor of Nox2), GKT137831 (a specific inhibitor of Nox4), and apocynin (a non-specific Nox inhibitor) were used to test the role of Nox2 and Nox4...
March 22, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28327974/intracranial-aneurysm-parameters-for-predicting-a-future-subarachnoid-hemorrhage-a-long-term-follow-up-study
#12
Seppo Juvela, Miikka Korja
BACKGROUND: Retrospective studies have suggested that aneurysm morphology is a risk factor for subarachnoid hemorrhage (SAH). OBJECTIVE: To investigate whether various morphological indices of unruptured intracranial aneurysms (UIAs) predict a future rupture. METHODS: A total of 142 patients with UIAs diagnosed between 1956 and 1978 were followed prospectively until SAH, death, or the last contact. Morphological UIA indices from standard angiographic projections were measured at baseline and adjusted in multivariable Cox proportional hazards regression analyses for established risk factors for SAH...
January 10, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28327970/in-reply-early-moderate-hyperoxemia-does-not-predict-outcome-after-aneurysmal-subarachnoid-hemorrhage
#13
Maarit Lång, Rahul Raj, Markus Benedikt Skrifvars, Matti Reinikainen, Stepani Bendel
No abstract text is available yet for this article.
March 17, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28327950/a-new-classification-for-pathologies-of-spinal-meninges-part-2-primary-and-secondary-intradural-arachnoid-cysts
#14
Jörg Klekamp
BACKGROUND: Spinal intradural arachnoid cysts are rare causes of radiculopathy or myelopathy. Treatment options include resection, fenestration, or cyst drainage. OBJECTIVE: To classify intradural spinal arachnoid cysts and present results of their treatment. METHODS: Among 1519 patients with spinal space occupying lesions, 130 patients demonstrated intradural arachnoid cysts. Neuroradiological and surgical features were reviewed and clinical data analyzed...
March 10, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28327929/letter-early-moderate-hyperoxemia-does-not-predict-outcome-after-aneurysmal-subarachnoid-hemorrhage
#15
Kailei Du, Yanfei Shen
No abstract text is available yet for this article.
March 15, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28327921/the-superior-cerebellar-artery-aneurysm-a-posterior-circulation-aneurysm-with-favorable-microsurgical-outcomes
#16
Ana Rodríguez-Hernández, Brian P Walcott, Harjus Birk, Michael T Lawton
BACKGROUND: Superior cerebellar artery (SCA) aneurysms are usually grouped with aneurysms that arise from the upper basilar artery or more broadly, the posterior circulation. However, the SCA aneurysm has distinctive anatomy that facilitates safe surgical management, notably few associated perforating arteries, and excellent exposure in the carotid-oculomotor triangle. OBJECTIVE: To demonstrate the outcomes of patients treated with microsurgery in a continuous surgical series...
January 24, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28327912/long-term-neurological-outcome-and-quality-of-life-after-world-federation-of-neurosurgical-societies-grades-iv-and-v-aneurysmal-subarachnoid-hemorrhage-in-an-interdisciplinary-treatment-concept
#17
Christoph Schwartz, Thomas Pfefferkorn, Caroline Ebrahimi, Caroline Ottomeyer, Gunther Fesl, Andreas Bender, Andreas Straube, Hans-Walter Pfister, Suzette Heck, Jörg-Christian Tonn, Christian Schichor
BACKGROUND: Detailed data on long-term functional outcome of patients with World Federation of Neurosurgical Societies (WFNS) grades IV and V aneurysmal subarachnoid hemorrhages (aSAH) are still scarce. OBJECTIVE: Assessment of long-term outcome of WFNS IV and V aSAH patients. METHODS: Functional outcome and quality of life were assessed by the modified Rankin scale (mRS) and the 36-item short-form health survey in consecutively treated aSAH WFNS IV and V patients between 2005 and 2010...
February 2, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28327595/x-linked-inhibitor-of-apoptosis-inhibits-apoptosis-and-preserves-the-blood-brain-barrier-after-experimental-subarachnoid-hemorrhage
#18
Cheng Gao, Hongwei Yu, Cong Yan, Wenyang Zhao, Yao Liu, Dongdong Zhang, Jingwei Li, Nan Liu
Early brain injury following subarachnoid hemorrhage (SAH) strongly determines the prognosis of patients suffering from an aneurysm rupture, and apoptosis is associated with early brain injury after SAH. This study was designed to explore the role of X-linked inhibitor of apoptosis (XIAP) in early brain injury following SAH. The expression of XIAP was detected using western blotting and real-time RT-PCR in an autologous blood injection model of SAH. We also studied the role of XIAP in early brain injury and detected apoptosis-related proteins...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28327554/ppar%C3%AE-%C3%AE-a-novel-regulator-for-vascular-smooth-muscle-cells-phenotypic-modulation-and-vascular-remodeling-after-subarachnoid-hemorrhage-in-rats
#19
Hongrong Zhang, Li Jiang, Zongduo Guo, Jianjun Zhong, Jingchuan Wu, Junchi He, Han Liu, Zhaohui He, Haitao Wu, Chongjie Cheng, Xiaochuan Sun
Cerebral vascular smooth muscle cell (VSMC) phenotypic switch is involved in the pathophysiology of vascular injury after aneurysmal subarachnoid hemorrhage (aSAH), whereas the molecular mechanism underlying it remains largely speculative. Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) has been implicated to modulate the vascular cells proliferation and vascular homeostasis. In the present study, we investigated the potential role of PPARβ/δ in VSMC phenotypic switch following SAH. Activation of PPARβ/δ by GW0742 and adenoviruses PPARβ/δ (Ad-PPARβ/δ) significantly inhibited hemoglobin-induced VSMC phenotypic switch...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28325378/-epidemiology-of-strokes-in-pediatry
#20
Yannick Béjot, Benoit Delpont, Christelle Blanc, Véronique Darmency, Frédéric Huet, Maurice Giroud
Incidence of perinatal arterial stroke (ischemic stroke, intracerebral hemorrhage and subarachnoid hemorrhage) occurring between 20 weeks of gestation and postnatal day 28 ranges between 20 and 65 cases per 100,000 living births. In children aged 29 days to 18 years old, the total incidence is 1.3 to 4.3 for 100,000 per year. In France, almost 450 children are hospitalized for a stroke each year, among them approximately half have an intracerebral hemorrhage.
March 2017: Soins. Pédiatrie, Puériculture
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