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subarachnoid hemorrhage 

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https://www.readbyqxmd.com/read/29457737/determining-the-value-of-cerebrospinal-fluid-lactate-dehydrogenase-level-in-differentiating-subarachnoid-hemorrhage-from-traumatic-lumbar-puncture
#1
Morteza Saeedi, Elnaz Vahidi, Shirin Asri, Amirhosein Jahanshir
CONTEXT: - Lumbar puncture (LP) is still an important modality in the diagnosis of subarachnoid hemorrhage (SAH). Rapid and correct fluid analysis can provide patients with a better prognosis by appropriate intervention. OBJECTIVE: - To determine the value of cerebrospinal fluid lactate dehydrogenase level in differentiation between SAH and traumatic LP. DESIGN: - This was a cross-sectional observational study. Patients with a diagnostic suspicion of SAH, who were admitted to the emergency department, were enrolled in our study based on the inclusion criteria...
February 19, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29456977/epidemiologic-and-demographic-features-therapeutic-intervention-and-prognosis-of-the-patients-with-cerebral-aneurysm
#2
Masih Sabouri, Amir Mahabadi, Homayoun Tabesh, Majeed Rezvani, Masih Kouchekzadeh, Ali Namazi
Background: Cerebral aneurysms are a kind of cardiovascular diseases which are accompanied with high morbidity and mortality due to rupturing and causing subarachnoid hemorrhages. The current study aimed to determine epidemiologic and demographic features and prognosis of patients with cerebral aneurysms. Materials and Methods: In this cross-sectional study, 465 patients with cerebral aneurysms hospitalized in Al-Zahra Hospital were studied. The required information including demographic, epidemiologic, and clinical features of the disease were extracted from their records...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29456646/an-experimental-rabbit-model-of-symptomatic-cerebral-vasospasm-with-in-vivo-neuroimaging-assessment-and-ex-vivo-histological-validation
#3
Yunchang Mo, Luping Huang, Linbi Chen, Michael Veronesi, Yiyi Shi, Sijia Chen, Linli Peng, Leping Zhou, Yonglin Pu, Junlu Wang
Cerebral vasospasm (CVS) is a severe complication that occurs following aneurysmal subarachnoid hemorrhage (SAH). Magnetic resonance angiography (MRA) has been used to evaluate brain injury following SAH in humans. The present study was designed to assess a rabbit model of symptomatic CVS (SCVS) and the utility of MRA in evaluating SCVS in rabbits. Japanese white rabbits (n=24) were randomly divided into 2 equal groups: A sham group and a SAH group. Neurological scores were evaluated for 7 days following SAH...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29455413/influence-of-abo-blood-type-on-the-outcome-after-non-aneurysmal-subarachnoid-hemorrhage
#4
Daniel Dubinski, Sae-Yeon Won, Bedjan Behmanesh, Sepide Kashefiolasl, Christof Geisen, Volker Seifert, Christian Senft, Juergen Konczalla
BACKGROUND: In patients with non-aneurysmal subarachnoid hemorrhage (NA-SAH), the etiology is unknown and the bleeding source remains unidentified. However, the ABO blood type system has a profound role in patient's hemostasis and thrombosis. To date, the aspect of ABO blood type in incidence, clinical course, and outcome after NA-SAH has not been investigated. METHODS: In this retrospective analysis, 81 patients with non-traumatic and non-aneurysmal subarachnoid hemorrhage treated between 2010 and 2014 at the author's institution were included...
February 17, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29454960/a-case-of-subarachnoid-hemorrhage-from-ruptured-oncotic-fusiform-aneurysms-from-choriocarcinoma-metastasis-treated-with-aneurysmectomy-and-vessel-reconstruction
#5
Yuichi Ito, Yoshio Araki, Takashi Izumi, Sho Okamoto, Masaaki Kimura, Toshihiko Wakabayashi
BACKGROUND: Oncotic aneurysm is a rare condition with a high mortality rate. Since no consensus has been reached regarding therapeutic strategy for ruptured oncotic aneurysm, treatment remains challenging. CASE DESCRIPTION: A 35-year-old woman developed sudden onset of severe headache. Computed tomography showed subarachnoid hemorrhage and cerebral angiography revealed two fusiform aneurysms in the distal portion of the left middle cerebral artery. Aneurysmectomy with vessel reconstruction using a superficial temporal artery graft was performed to maintain blood flow to the distal middle cerebral artery...
February 15, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29451456/clival-meningocele-causing-bilateral-hearing-loss-in-a-child-due-to-superficial-siderosis-of-the-central-nervous-system-case-report
#6
Stephen J Johans, Kevin N Swong, Daniel J Burkett, Michael P Wemhoff, Sean M Lew, Chirag R Patel, Anand V Germanwala
Superficial siderosis (SS) of the CNS is a rare and often unrecognized condition. Caused by hemosiderin deposition from chronic, repetitive hemorrhage in the subarachnoid space, it results in parenchymal damage in the subpial layers of the brain and spinal cord. T2-weighted MRI shows the characteristic hypointensity of hemosiderin deposition, classically occurring around the cerebellum, brainstem, and spinal cord. Patients present with progressive gait ataxia and sensorineural hearing impairment. Although there have been several studies, case reports, and review articles over the years, the clear pathophysiology of subarachnoid space hemorrhage remains to be elucidated...
February 16, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29449516/-a-case-of-a-ruptured-cerebral-aneurysm-associated-with-microscopic-polyangiitis
#7
Toshihide Takahashi, Wataru Katayama, Yuji Kujiraoka, Tetsuya Yamamoto, Akira Matsumura
CASE: A 71-year-old woman was receiving dialysis for microscopic polyangiitis(MPA). She was transported to the emergency room after developing a headache and losing consciousness. She was in a coma and had dense left paralysis. Head computed tomography(CT)showed a subarachnoid hemorrhage. Head three-dimensional CT angiography showed an aneurysm proximal to the right M2(inferior trunk), which was considered as the source of bleeding. We performed an emergency aneurysm clipping surgery...
February 2018: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/29448133/exposure-to-the-rock-inhibitor-fasudil-promotes-gliogenesis-of-neural-stem-cells-in-vitro
#8
Zubair Ahmed Nizamudeen, Lisa Chakrabarti, Virginie Sottile
Fasudil is a clinically approved Rho-associated protein kinase (ROCK) inhibitor that has been used widely to treat cerebral consequences of subarachnoid hemorrhage. It is known to have a positive effect on animal models of neurological disorders including Parkinson's disease and stroke. However, its cellular effect on progenitor populations and differentiation is not clearly understood. While recent studies suggest that fasudil promotes the mobilization of neural stem cells (NSCs) from the subventricular zone in vivo and promotes the differentiation of the C17...
February 6, 2018: Stem Cell Research
https://www.readbyqxmd.com/read/29445965/traumatic-subarachnoid-hemorrhage-related-to-ophthalmic-artery-avulsion-a-case-report
#9
Alessandro Prior, Luca Allegretti, Ilaria Melloni, Marta Bovio, Francesco Laganà, Marco Ceraudo, Gianluigi Zona
We present a case of ophthalmic artery (OA) traumatic avulsion, leading to a post-traumatic subarachnoid hemorrhage (SAH) with ventricular blood invasion and hydrocephalus, mimicking an internal carotid aneurysm rupture. This is the third case of such an event reported in literature and the first without orbital fractures and optic nerve avulsion. Conservative treatment was sufficient for the avulsion, but surgery was needed for the coexisting eye luxation. Traumatic OA avulsion is a rare but possible event and should be suspected in case of basal cisterns SAH, evidence of orbital trauma and CT angiogram or angiographic absence of opacification of the OA...
February 14, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29445430/seizure-prophylaxis-in-the-immediate-post-hemorrhagic-period-in-patients-with-aneurysmal-subarachnoid-hemorrhage
#10
Thomas V Kodankandath, Salman Farooq, Wled Wazni, John-Andrew Cox, Christopher Southwood, Gregory Rozansky, Vijay Johnson, John R Lynch
Introduction: Seizures are a well-known complication of aneurysmal subarachnoid hemorrhage (aSAH) and occur most commonly in the immediate posthemorrhagic period. Most commonly used antiepileptic drugs (AEDs) for seizure prophylaxis in aSAH include phenytoin and levetiracetam. There is no reliable data available on the safety and efficacy of restricting AED prophylaxis only till the aneurysm is secured. Methods: We retrospectively chart reviewed patients admitted to our neurosciences intensive care unit (NICU) with aSAH during the past two years...
December 2017: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/29445328/hippocampal-atrophy-following-subarachnoid-hemorrhage-correlates-with-disruption-of-astrocyte-morphology-and-capillary-coverage-by-aqp4
#11
Maryam Anzabi, Maryam Ardalan, Nina K Iversen, Ali H Rafati, Brian Hansen, Leif Østergaard
Despite successful management of ruptured intracranial aneurysm following subarachnoid hemorrhage (SAH), delayed cerebral ischemia (DCI) remains the main cause of high mortality and morbidity in patients who survive the initial bleeding. Astrocytes play a key role in neurovascular coupling. Therefore, changes in the neurovascular unit including astrocytes following SAH may contribute to the development of DCI and long-term complications. In this study, we characterized morphological changes in hippocampal astrocytes following experimental SAH, with special emphasis on glia-vascular cross-talk and hippocampal volume changes...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29440341/validation-of-the-ottawa-subarachnoid-hemorrhage-rule-in-patients-with-acute-headache
#12
(no author information available yet)
No abstract text is available yet for this article.
February 12, 2018: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/29438791/necessity-of-repeat-ct-imaging-in-isolated-mild-traumatic-subarachnoid-hemorrhage
#13
Ashwath Kumar, Anthony Alvarado, Kushal Shah, Paul M Arnold
BACKGROUND: The standard of care for isolated mild traumatic subarachnoid hemorrhage (itSAH) involves serial head CT examinations at dedicated time-intervals to monitor neurologic status and hemorrhagic progression. Considering recent evidence questioning such an aggressive monitoring protocol, this study aimed to assess the necessity of repeat head CT imaging in managing itSAH. METHODS: All patients who presented to our academic institution with mild traumatic brain injury were evaluated...
February 10, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29438081/microvasospasms-after-experimental-subarachnoid-hemorrhage-do-not-depend-on-endothelin-a-receptors
#14
Hanhan Liu, Ari Dienel, Karsten Schöller, Susanne M Schwarzmaier, Kathrin Nehrkorn, Nikolaus Plesnila, Nicole A Terpolilli
BACKGROUND AND PURPOSE: Perturbations in cerebral microcirculation (eg, microvasospasms) and reduced neurovascular communication determine outcome after subarachnoid hemorrhage (SAH). ET-1 (endothelin-1) and its receptors have been implicated in the pathophysiology of large artery spasms after SAH; however, their role in the development of microvascular dysfunction is currently unknown. Here, we investigated whether inhibiting ET A (endothelin A) receptors can reduce microvasospasms after experimentally induced SAH...
February 8, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29437934/morphological-characteristics-associated-with-the-rupture-risk-of-mirror-posterior-communicating-artery-aneurysms
#15
Guang-Xian Wang, Jun Liu, You-Qiang Chen, Li Wen, Ming-Guang Yang, Ming-Fu Gong, Dong Zhang
OBJECTIVE: Patient related clinical factors and intracranial aneurysms (IAs) at different locations may lead to statistical bias when investigating the rupture risk of IAs. Thus the purpose of this study was to identify the morphological parameters that are related to the rupture of mirror posterior communicating artery aneurysms (PComAAs). METHODS: Between August 2011 and July 2017, 68 patients with mirror PComAAs and aneurysmal subarachnoid hemorrhage were diagnosed by CT angiography at three medical centers...
February 2, 2018: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29437311/sudden-headache-lumbar-puncture-and-the-diagnosis-of-subarachnoid-hemorrhage-in-patients-with-a-normal-computed-tomography-scans
#16
Joaquín Valle Alonso, Francisco Javier Fonseca Del Pozo, Manuel Vaquero Álvarez, Juan José De la Fuente Carillo, José Carlos Llamas, Yelda Hernández Montes
OBJECTIVES: To assess the usefulness of computed tomography (CT) to identify subarachnoid bleeding in patients with neurologic deficits seeking emergency care for sudden headache within 6 hours of onset of symptoms. MATERIAL AND METHODS: Retrospective observational study of patients presenting with sudden nontraumatic headache peaking during the previous hour in the absence of neurologic deficits. We ordered CT scans for all patients, and if the scan was normal we performed a lumbar puncture...
February 2018: Emergencias: Revista de la Sociedad Española de Medicina de Emergencias
https://www.readbyqxmd.com/read/29435280/analysis-of-the-clinical-characteristics-of-hemorrhagic-moyamoya-disease-in-the-jilin-province-of-northeastern-china-a-single-center-study-of-212-cases
#17
Qinglian Li, Lai Qu, Yongjie Yuan, Baofeng Xu, Yunbao Guo, Kan Xu, Jinlu Yu
The present study aimed to investigate the clinical characteristics of hemorrhagic moyamoya disease (MMD) in Jilin province in northeast China. A total of 212 cases of hemorrhagic MMD were consecutively enrolled from the First Hospital of Jilin University in Changchun, China between January 2011 and January 2015. The patients' general clinical data, including age and gender characteristics, history of previous illnesses, hemorrhage type and onset symptoms, Hunt-Hess classification at admission, imaging characteristics, association with aneurysms, treatments and prognosis, were recorded and analyzed using SPSS 19...
February 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29434767/simvastatin-inhibits-the-apoptosis-of-hippocampal-cells-in-a-mouse-model-of-alzheimer-s-disease
#18
Xiaoqin Hu, Chengwei Song, Ming Fang, Chengyan Li
Alzheimer's disease is associated with cognitive impairments that affect memory and executive functions. Simvastatin is a cholesterol-lowering statin drug that is used to control levels of cholesterol in the blood, particularly in cases of hypercholesterolemia, and may be used in the treatment of aneurysmal subarachnoid hemorrhage. Previous results have indicated that the apoptosis of hippocampal cells may serve a critical role in the progression of Alzheimer's disease. In the present study, it was determined whether Simvastatin inhibited the apoptosis of hippocampal cells in vitro and in vivo ...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29434735/expression-of-mmp-9-and-il-6-in-patients-with-subarachnoid-hemorrhage-and-the-clinical-significance
#19
Luchen Wang, Ziyun Gao
The purpose of the present study was to investigate the expression of matrix metalloproteinase-9 (MMP-9) and interleukin-6 (IL-6) in patients with subarachnoid hemorrhage (SAH) and the clinical significance thereof. Forty-three patients with SAH and 23 healthy individuals were enrolled in this study. Patients were divided into the cerebral vasospasm (CVS) and non-cerebral vasospasm (non-CVS) groups, or the good and poor prognosis groups. Serum levels of MMP-9 and IL-6 were detected by ELISA. Expression levels of MMP-9 and IL-6 mRNAs were detected by RT-qPCR...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29434719/ag490-ameliorates-early-brain-injury-via-inhibition-of-jak2-stat3-mediated-regulation-of-hmgb1-in-subarachnoid-hemorrhage
#20
Ji-Yang An, Hong-Gang Pang, Ting-Qin Huang, Jin-Ning Song, Dan-Dong Li, Yong-Lin Zhao, Xu-Dong Ma
High mobility group box 1 (HMGB1) is a classic damage-associated molecular pattern that has an important role in the pathological inflammatory response. In vitro studies have demonstrated that the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathway is involved in the regulation of HMGB1 expression, mediating the inflammatory response. Therefore, the purpose of the present study was to evaluate JAK2/STAT3 pathway involvement in the subarachnoid hemorrhage (SAH)-dependent regulation of HMGB1, using an in vivo rat model...
February 2018: Experimental and Therapeutic Medicine
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