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https://www.readbyqxmd.com/read/29935053/luteolin-decreases-egfr-mediated-cell-proliferation-and-induces-apoptosis-in-glioblastoma-cell-lines
#1
David M Anson, Rachel M Wilcox, Eric D Huseman, Trevor A Stump, Robert L Paris, Belinda O Darkwah, Stacy Lin, Andrea O Adegoke, Rebecca J Gryka, Denise S Jean-Louis, Samson Amos
Glioblastomas are a subtype of gliomas, which are the most aggressive and deadly form of brain tumours. The epidermal growth factor receptor (EGFR) is over-expressed and amplified in glioblastomas. Luteolin is a common bioflavonoid found in a variety of fruits and vegetables. The aim of the present study was to explore the molecular and biological effects of luteolin on EGF-induced cell proliferation and the potential of luteolin to induce apoptosis in glioblastoma cells. In vitro cell viability assays demonstrated that luteolin decreased cell proliferation in the presence or absence of EGF...
June 23, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29934952/cervical-necrotizing-fasciitis-systematic-review-and-analysis-of-1235-reported-cases-from-the-literature
#2
REVIEW
Dakshika A Gunaratne, Evan A Tseros, Zubair Hasan, Akshay S Kudpaje, Anand Suruliraj, Mark C Smith, Faruque Riffat, Carsten E Palme
BACKGROUND: Cervical necrotizing fasciitis is a progressive soft tissue infection with significant morbidity and mortality. METHODS: A case review of cervical necrotizing fasciitis managed at our institution (2007-2017) and a systematic review of PubMed, MEDLINE, and EMBASE databases using the algorithm "(cervical OR neck) AND necrotizing fasciitis." RESULTS: There were 1235 cases from 207 articles which were included in our clinical review...
June 22, 2018: Head & Neck
https://www.readbyqxmd.com/read/29933823/nontraditional-alcohol-and-opioid-agonist-treatment-interventions
#3
REVIEW
Christopher Fairgrieve, Nadia Fairbairn, Jeffrey H Samet, Seonaid Nolan
Despite the availability of effective medications and psychosocial interventions for the management of a substance use disorder, some individuals repeatedly fail the most aggressive treatment regimens. For such individuals, alternative treatment options exist seeking to mitigate the negative consequences of the use of harmful substances. Participation in a managed alcohol program, or the use of sustained-release oral morphine or injectable opioid agonist treatment or the creation of safe injecting facilities, are examples of such nonstandard approaches...
July 2018: Medical Clinics of North America
https://www.readbyqxmd.com/read/29932988/inhibition-of-the-anxa1-fpr1-autocrine-axis-reduces-mda-mb-231-breast-cancer-cell-growth-and-aggressiveness-in-vitro-and-in-vivo
#4
Lara Vecchi, Mariana Alves Pereira Zoia, Tiago Goss Santos, Adriano de Oliveira Beserra, Cristiano Manuel Colaço Ramos, Bruna França Matias Colombo, Yara Cristina Paiva Maia, Victor Piana de Andrade, Sara Teixeira Soares Mota, Thaise Gonçalves de Araújo, Fernanda Van Petten de Vasconcelos Azevedo, Fernando Augusto Soares, Sonia Maria Oliani, Luiz Ricardo Goulart
Breast Cancer (BC) is a highly heterogeneous disease whose most aggressive behavior is displayed by triple-negative breast cancer (TNBC), which lacks an efficient targeted therapy. Despite its controversial role, one of the proteins that having been linked with BC is Annexin A1 (AnxA1), which is a Ca+2 binding protein that acts modulating the immune system, cell membrane organization and vesicular trafficking. In this work we analyzed tissue microarrays of BC samples and observed a higher expression of AnxA1 in TNBCs and in lymph node metastasis...
June 19, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29930995/management-of-localized-aggressive-periodontitis-a-30-year-follow-up
#5
Catherine Petit, Olivier Huck, Salomon Amar, Henri Tenenbaum
This case report describes the long-term follow-up of a patient with localized aggressive periodontitis over a 30-year period. A 16-year-old woman was referred for periodontal assessment after starting orthodontic treatment. The patient was treated initially by combined nonsurgical and antimicrobial therapy, and autotransplantation of maxillary third molars in place of maxillary first molars, followed by a regular supportive periodontal treatment program. This challenging case demonstrated that elimination of putative bacterial pathogens and long-term supportive periodontal treatments provide an effective treatment modality for localized aggressive periodontitis...
June 21, 2018: Quintessence International
https://www.readbyqxmd.com/read/29929812/-fulminant-hepatic-failure-after-simultaneous-kidney-pancreas-transplantation-a-case-report
#6
Jimmy L Moss, Benjamin W Brown, Sher-Lu Pai, Klaus D Torp, Stephen Aniskevich
We describe an unusual case of hyperacute hepatic failure following general anesthesia in a patient receiving a simultaneous kidney-pancreas transplant. Despite an aggressive evaluation of structural, immunological, viral, and toxicological causes, a definitive cause could not be elucidated. The patient required a liver transplant and suffered a protracted hospital course. We discuss the potential causes of fulminant hepatic failure and the perioperative anesthesia management of her subsequent liver transplantation...
June 18, 2018: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/29929537/aggression-following-traumatic-brain-injury-effectiveness-of-risperidone-after-study-protocol-for-a-feasibility-randomised-controlled-trial
#7
Shoumitro Deb, Verity Leeson, Lina Aimola, Mayur Bodani, Lucia Li, Tim Weaver, David Sharp, Mike Crawford
BACKGROUND: Traumatic brain injury (TBI) is a major public health concern and many people develop long-lasting physical and neuropsychiatric consequences following a TBI. Despite the emphasis on physical rehabilitation, it is the emotional and behavioural consequences that have greater impact on people with TBI and their families. One such problem behaviour is aggression which can be directed towards others, towards property or towards the self. Aggression is reported to be common after TBI (37-71%) and causes major stress for patients and their families...
June 21, 2018: Trials
https://www.readbyqxmd.com/read/29928823/weaning-and-mixed-mania-a-case-report
#8
Verinder Sharma
INTRODUCTION: The development of mania during weaning is an underreported phenomenon that has received little attention in the recent past. Lack of timely diagnosis and effective management can negatively affect not only the mother but also her family. Main issue: I describe the case of a woman who experienced onset of mixed mania during weaning. At that time, she was diagnosed with bipolar I disorder, current episode manic, and a mixed-features specifier. The woman had a history of bipolar II disorder and a family history of postpartum depression and bipolar disorder...
June 1, 2018: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/29928614/incidence-of-urinary-extravasation-and-rate-of-ureteral-stenting-after-high-grade-renal-trauma-in-adults-a-meta-analysis
#9
Sorena Keihani, Ross E Anderson, Michelle Fiander, Mary M McFarland, Gregory J Stoddard, James M Hotaling, Jeremy B Myers
Background: Collecting system injury and urinary extravasation is an important yet understudied aspect of renal trauma. We aimed to examine the incidence of urinary extravasation and also the rates of ureteral stenting after high-grade renal trauma (HGRT) in adults. Methods: A search strategy was developed to search Ovid Medline, Embase, CINAHL, and Cochrane Library. Two reviewers screened titles and abstracts, followed by full-text review of the relevant publications...
May 2018: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29928602/quantification-of-sarcomatoid-differentiation-in-renal-cell-carcinoma-on-magnetic-resonance-imaging
#10
Daniel Jeong, Natarajan Raghunand, Diego Hernando, Michael Poch, Katherine Jeong, Brendan Eck, Jasreman Dhillon
Background: Sarcomatoid differentiation in renal cell carcinoma (sRCC) is histologically characterized by anaplastic changes of renal cell carcinoma (RCC) subtypes, which has been associated with a poor prognosis. sRCC is managed more aggressively than RCC without sarcomatoid components, so pre-operative detection of sarcomatoid differentiation would significantly affect surgical management. The purpose of this study is to compare the quantification of sarcomatoid features in RCCs on pre-operative magnetic resonance imaging (MRI) to standard histological examination...
May 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29928563/a-novel-minimally-invasive-technique-in-the-management-of-a-large-cyst-involving-the-maxilla-in-a-child-a-case-report
#11
Kishore Moturi, Divya Puvvada, Padma Rayalu Kotha
The conservative management of large, odontogenic, developmental cysts involving the jaws in young children using the technique of decompression has become increasingly popular to reduce the incidence of morbidity associated with aggressive treatment modalities. The lack of development of a stock device has made clinicians to explore various possible and readily available materials to customize the devices. This paper highlights the use of a novel material to be used as a decompression device that is readily available and can be used with good patient compliance and a predictable outcome...
April 18, 2018: Curēus
https://www.readbyqxmd.com/read/29928456/the-role-of-radiation-therapy-in-the-management-of-small-cell-lung-cancer
#12
REVIEW
Markus Glatzer, Sabine Schmid, Marco Radovic, Martin Früh, Paul Martin Putora
Small cell lung cancer (SCLC) is a very aggressive form of lung cancer. SCLC treatment requires multidisciplinary management and timely treatment. Radiation therapy is an important part of management of all stages of SCLC, in the curative as well as in the palliative setting. The role of radiation therapy in all stages of SCLC has changed in recent years; this article describes these changes and highlights the role of radiation therapy in the management of SCLC.
December 2017: Breathe
https://www.readbyqxmd.com/read/29928186/hypothermia-related-acute-pancreatitis
#13
Kyawzaw Lin, Emmanuel Ofori, Aung Naing Lin, Sithu Lin, Thinzar Lin, Ameer Rasheed, Viswanath Vasudevan, Madhavi Reddy
Acute pancreatitis (AP) is an inflammatory disease presenting from mild localized inflammation to severe infected necrotic pancreatic tissue. In the literature, there are a few cases of hypothermia-induced AP. However, the association between hypothermia and AP is still a myth. Generally, mortality from acute pancreatitis is nearly 3-6%. Here, we present a 40-year-old chronic alcoholic female who presented with acute pancreatitis induced by transient hypothermia. A 40-year-old chronic alcoholic female was hypothermic at 81°F on arrival which was improved to 91...
May 2018: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29927442/-extraskeletal-osteosarcoma-nosologocal-diversity-morphology-differential-diagnosis-and-features-of-metastasis
#14
N V Vasiliev, S V Poletaeva, S A Maltseva, A А Zheravin, Yu I Tyukalov, P G Baidala
Extraskeletal osteosarcoma is a rare malignant tumor with histologic similarities to primary bone osteosarcoma. However, there are distinct differences in epidemiology, imaging features, biological characteristics, prognosis, and management compared with osteogenic osteosarcoma. Extraskeletal osteosarcoma is usually characterized as high-grade neoplasm with clinically aggressive behavior, poor prognosis, frequent recurrence/lymphogenic metastatsis, and resistence to chemotherapy. A noteworthy feature of extraskeletal osteosarcoma is the fact that almost all existing biological phenomena described in mesenchymal oncopathology (except primary-multiple lesions) are present in this tumor, namely: secondary malignancy, association with syndromes, partial spontaneous regression of the tumor, dedifferentiation, bone invasion, biphasic pathology...
2018: Arkhiv Patologii
https://www.readbyqxmd.com/read/29927282/caregiver-behaviors-associated-with-emotion-regulation-in-high-risk-preschoolers
#15
Christina N Caiozzo, Kristen Yule, John Grych
Children who witness violence are at risk for developing a range of developmental problems, including deficits in understanding and regulating. The ability to adaptively manage emotions is associated with children's mental health and their social and academic competence; however, little is known about how parents of at-risk youth can foster the healthy development of emotion regulation. The current study aimed to identify specific parenting practices associated with adaptive emotion regulation in at-risk preschoolers...
June 21, 2018: Journal of Family Psychology: JFP
https://www.readbyqxmd.com/read/29926951/periodontitis-consensus-report-of-workgroup-2-of-the-2017-world-workshop-on-the-classification-of-periodontal-and-peri-implant-diseases-and-conditions
#16
Panos N Papapanou, Mariano Sanz, Nurcan Buduneli, Thomas Dietrich, Magda Feres, Daniel H Fine, Thomas F Flemmig, Raul Garcia, William V Giannobile, Filippo Graziani, Henry Greenwell, David Herrera, Richard T Kao, Moritz Kebschull, Denis F Kinane, Keith L Kirkwood, Thomas Kocher, Kenneth S Kornman, Purnima S Kumar, Bruno G Loos, Eli Machtei, Huanxin Meng, Andrea Mombelli, Ian Needleman, Steven Offenbacher, Gregory J Seymour, Ricardo Teles, Maurizio S Tonetti
A new periodontitis classification scheme has been adopted, in which forms of the disease previously recognized as "chronic" or "aggressive" are now grouped under a single category ("periodontitis") and are further characterized based on a multi-dimensional staging and grading system. Staging is largely dependent upon the severity of disease at presentation as well as on the complexity of disease management, while grading provides supplemental information about biological features of the disease including a history-based analysis of the rate of periodontitis progression; assessment of the risk for further progression; analysis of possible poor outcomes of treatment; and assessment of the risk that the disease or its treatment may negatively affect the general health of the patient...
June 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29926490/periodontitis-consensus-report-of-workgroup-2-of-the-2017-world-workshop-on-the-classification-of-periodontal-and-peri-implant-diseases-and-conditions
#17
Panos N Papapanou, Mariano Sanz, Nurcan Buduneli, Thomas Dietrich, Magda Feres, Daniel H Fine, Thomas F Flemmig, Raul Garcia, William V Giannobile, Filippo Graziani, Henry Greenwell, David Herrera, Richard T Kao, Moritz Kebschull, Denis F Kinane, Keith L Kirkwood, Thomas Kocher, Kenneth S Kornman, Purnima S Kumar, Bruno G Loos, Eli Machtei, Huanxin Meng, Andrea Mombelli, Ian Needleman, Steven Offenbacher, Gregory J Seymour, Ricardo Teles, Maurizio S Tonetti
A new periodontitis classification scheme has been adopted, in which forms of the disease previously recognized as "chronic" or "aggressive" are now grouped under a single category ("periodontitis") and are further characterized based on a multi-dimensional staging and grading system. Staging is largely dependent upon the severity of disease at presentation as well as on the complexity of disease management, while grading provides supplemental information about biological features of the disease including a history-based analysis of the rate of periodontitis progression; assessment of the risk for further progression; analysis of possible poor outcomes of treatment; and assessment of the risk that the disease or its treatment may negatively affect the general health of the patient...
June 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29925554/cogan-s-syndrome-with-pyoderma-gangrenosum-management-of-two-uncommon-disorders-with-aggressive-presentation-in-a-patient
#18
Ezolene Pei-Chin Chua, Richard B Mallett, Sandeep Dahiya
Pyoderma gangrenosum (PG) coexisting with Cogan's syndrome (CS) is uncommon, although cutaneous manifestations are known to develop in CS. A middle-aged white female patient had chronic relapsing PG requiring ciclosporin and prednisolone. Despite receiving optimal doses of ciclosporin and prednisolone, she developed acute vestibulo-auditory symptoms as a result of CS. Ciclosporin was switched to methotrexate and prednisolone was increased. However, she continued to develop acute scleritis, requiring methylprednisolone pulses, and still had further flares of PG...
June 19, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29924878/chiari-i-malformation-and-basilar-invagination-in-fibrous-dysplasia-prevalence-mechanisms-and-clinical-implications
#19
Kristen S Pan, John D Heiss, Sydney M Brown, Michael T Collins, Alison M Boyce
Fibrous dysplasia (FD) is a mosaic disorder of benign fibro-osseous lesions, which may be associated with extraskeletal features as part of McCune-Albright syndrome (MAS). Cranial base abnormalities, including Chiari I malformation (CM1), in which the cerebellum extends below the foramen magnum, and secondary basilar invagination (BI), in which the odontoid prolapses into the posterior cranial fossa, are potentially serious complications of metabolic bone disorders. The purpose of this study was to determine the prevalence, natural history, and risk factors for CM1 and BI in patients with FD/MAS, and to determine mechanisms of cranial base deformities...
June 20, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29923487/papillary-thyroid-microcarcinoma-in-super-obese-patient
#20
R Ruggiero, A Bosco, R Pirozzi, M C Bondanese, G Gualtieri, L Docimo
Papillary thyroid microcarcinoma (PTMC) typically has an indolent behavior with a good prognosis but it is not always completely harmless. Surgical treatment varies from thyroid lobectomy to total thyroidectomy eventually associated with lymph node dissection and radioiodotherapy. The ability to identify patients with aggressive PTMCs from the majority of low risk patients is critical to planning proper clinical management. Several studies don't report any statistically significant differences about recurrence and mortality among patients undergone lobectomy and patients undergone total thyroidectomy...
May 2018: Il Giornale di Chirurgia
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