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https://www.readbyqxmd.com/read/28736196/serological-and-molecular-epidemiological-outcomes-after-two-decades-of-universal-infant-hepatitis-b-virus-hbv-vaccination-in-nunavut-canada
#1
Chris Huynh, Gerald Y Minuk, Julia Uhanova, Maureen Baikie, Thomas Wong, Carla Osiowy
Chronic hepatitis B virus (HBV) infection within the Canadian Arctic is considered endemic (>2% prevalence). Within the Arctic region of Nunavut, a vaccination program targeted at newborn infants was initiated approximately 20years ago, along with interim grade school catch-up programs, with the result that individuals born after 1980 are presumed vaccinated. This study investigates the effectiveness of these programs and is the first seroepidemiological survey to determine HBV prevalence in Nunavut in the post-vaccination era...
July 20, 2017: Vaccine
https://www.readbyqxmd.com/read/28735863/structural-insights-on-the-specific-recognition-of-dsr-by-the-yth-domain-containing-protein-mmi1
#2
Baixing Wu, Jinhao Xu, Shichen Su, Hehua Liu, Jianhua Gan, Jinbiao Ma
Meiosis is one of the most dramatic differentiation programs accompanied by a striking change in gene expression profiles, whereas a number of meiosis-specific transcripts are expressed untimely in mitotic cells. The entry of meiosis will be blocked as the accumulation of meiosis-specific mRNAs during the mitotic cell in fission yeast Schizosaccharomyces pombe. A YTH domain containing protein Mmi1 was identified as a pivotal effector in a post-transcriptional event termed selective elimination of meiosis-specific mRNAs, Mmi1 can recognize and bind a class of meiosis-specific transcripts expressed inappropriately in mitotic cells, which contain a conservative motif called DSR as a mark to remove them in cooperation with nuclear exosomes...
July 20, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28735790/patient-specific-finite-element-analysis-of-fiber-post-and-ferrule-design
#3
Monise de Paula Rodrigues, Priscilla Barbosa Ferreira Soares, Andréa Dollores Correia Miranda Valdivia, Roberto Sales Pessoa, Crisnicaw Veríssimo, Antheunis Versluis, Carlos José Soares
INTRODUCTION: A ferrule on anterior endodontic-treated teeth has been evaluated using clinical trials, in vitro tests, and finite element analysis (FEA). The patient-specific FEA with a nonuniform ferrule and nonlinear contact biting load associated with clinical validation can be used to predict failure. METHODS: A patient was selected with both maxillary central incisors with different ferrule designs who received endodontic treatment and restoration using a fiber post, composite core, and computer aided design and computer aided manufacturing lithium disilicate ceramic crowns...
July 20, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28735789/xp-shaper-a-novel-adaptive-core-rotary-instrument-micro-computed-tomographic-analysis-of-its-shaping-abilities
#4
Adham A Azim, Lucila Piasecki, Ulisses Xavier da Silva Neto, Alessandra Timponi Goes Cruz, Katharina A Azim
INTRODUCTION: The aim of this study was to investigate the shaping abilities of the XP Shaper (FKG, La Chaux-de-Fonds, Switzerland) and compare the findings with Vortex Blue (Dentsply Tulsa Dental Specialties, Tulsa, OK) using micro-computed tomographic imaging. METHODS: Twenty matched, extracted, mandibular, central incisors with a single, oval canal were scanned preoperatively at 25-μm resolution and postoperatively after instrumentation with either Vortex Blue in a crown-down manner up to size 30...
July 20, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28735436/assessing-differences-in-macrofaunal-assemblages-as-a-factor-of-sieve-mesh-size-distance-between-samples-and-time-of-sampling
#5
Lenaïg G Hemery, Kristin K Politano, Sarah K Henkel
With increasing cascading effects of climate change on the marine environment, as well as pollution and anthropogenic utilization of the seafloor, there is increasing interest in tracking changes to benthic communities. Macrofaunal surveys are traditionally conducted as part of pre-incident environmental assessment studies and post-incident monitoring studies when there is a potential impact to the seafloor. These surveys usually characterize the structure and/or spatiotemporal distribution of macrofaunal assemblages collected with sediment cores; however, many different sampling protocols have been used...
August 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28732225/influence-of-hypo-and-hyperthermia-on-death-time-estimation-a-simulation-study
#6
H Muggenthaler, M Hubig, S Schenkl, G Mall
Numerous physiological and pathological mechanisms can cause elevated or lowered body core temperatures. Deviations from the physiological level of about 37°C can influence temperature based death time estimations. However, it has not been investigated by means of thermodynamics, to which extent hypo- and hyperthermia bias death time estimates. Using numerical simulation, the present study investigates the errors inherent in temperature based death time estimation in case of elevated or lowered body core temperatures before death...
June 27, 2017: Legal Medicine
https://www.readbyqxmd.com/read/28728324/the-chicken-thigh-adductor-profundus-free-muscle-flap-a-novel-validated-non-living-microsurgery-simulation-training-model
#7
Georgios Pafitanis, Yasmine Serrar, Maria Raveendran, Ali Ghanem, Simon Myers
BACKGROUND: Simulation training is becoming an increasingly important component of skills acquisition in surgical specialties, including Plastic Surgery. Non-living simulation models have an established place in Plastic Surgical microsurgery training, and support the principles of replacement, reduction and refinement of animal use. A more sophisticated version of the basic chicken thigh microsurgery model has been developed to include dissection of a type 1-muscle flap and is described and validated here...
July 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/28727789/lumpgem-systematic-generation-of-subnetworks-and-elementally-balanced-lumped-reactions-for-the-biosynthesis-of-target-metabolites
#8
Meric Ataman, Vassily Hatzimanikatis
In the post-genomic era, Genome-scale metabolic networks (GEMs) have emerged as invaluable tools to understand metabolic capabilities of organisms. Different parts of these metabolic networks are defined as subsystems/pathways, which are sets of functional roles to implement a specific biological process or structural complex, such as glycolysis and TCA cycle. Subsystem/pathway definition is also employed to delineate the biosynthetic routes that produce biomass building blocks. In databases, such as MetaCyc and SEED, these representations are composed of linear routes from precursors to target biomass building blocks...
July 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28727266/next-generation-sequencing-of-cytologic-preparations-an-analysis-of-quality-metrics
#9
David H Hwang, Elizabeth P Garcia, Matthew D Ducar, Edmund S Cibas, Lynette M Sholl
BACKGROUND: Next-generation sequencing (NGS) fails for many small biopsies (BXs) because of a low overall DNA concentration or tumor percentage. Cytology smears and liquid-based preparations (LBPs), or smears/LBPs, often contain abundant tumor cells and may provide adequate material for molecular testing when other materials are insufficient. This study examined the performance of smears/LBPs on a clinical NGS assay. METHODS: This study retrospectively reviewed quality metrics from consecutive smear/LBP, core BX, and cell block (CB) cases run on a hybrid-capture NGS assay interrogating 309 cancer-related genes...
July 20, 2017: Cancer
https://www.readbyqxmd.com/read/28726481/a-randomized-controlled-trial-of-an-online-modular-active-learning-training-program-for-behavioral-activation-for-depression
#10
Ajeng J Puspitasari, Jonathan W Kanter, Andrew M Busch, Rachel Leonard, Shira Dunsiger, Shawn Cahill, Christopher Martell, Kelly Koerner
OBJECTIVE: This randomized-controlled trial assessed the efficacy of a trainer-led, active-learning, modular, online behavioral activation (BA) training program compared with a self-paced online BA training with the same modular content. METHOD: Seventy-seven graduate students (M = 30.3 years, SD = 6.09; 76.6% female) in mental health training programs were randomly assigned to receive either the trainer-led or self-paced BA training. Both trainings consisted of 4 weekly sessions covering 4 core BA strategies...
August 2017: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/28725581/direct-magnetic-resonance-imaging-guided-biopsy-of-the-prostate-lessons-learned-in-establishing-a-regional-referral-center
#11
REVIEW
Benjamin Addicott, Bryan R Foster, Chenara Johnson, Alice Fung, Christopher L Amling, Fergus V Coakley
MRI-targeted biopsy of the prostate appears to have the potential to reduce the high rates of underdiagnosis and overdiagnosis associated with the current diagnostic standard of transrectal ultrasound guided systematic biopsy. Direct or "in bore" MRI-guided biopsy is one of the three methods for MRI-targeted core needle sampling of suspicious, generally Pi-RADS 4 or 5, foci within the prostate, and our early experience suggests the approach demonstrates substantial utility and promise in the care of patients with prostate cancer...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28724418/improved-recovery-of-regional-left-ventricular-function-after-pci-of-chronic-total-occlusion-in-stemi-patients-a-cardiovascular-magnetic-resonance-study-of-the-randomized-controlled-explore-trial
#12
Joëlle Elias, Ivo M van Dongen, Loes P Hoebers, Dagmar M Ouweneel, Bimmer E P M Claessen, Truls Råmunddal, Peep Laanmets, Erlend Eriksen, René J van der Schaaf, Dan Ioanes, Robin Nijveldt, Jan G Tijssen, Alexander Hirsch, José P S Henriques
BACKGROUND: The Evaluating Xience and left ventricular function in PCI on occlusiOns afteR STEMI (EXPLORE) trial did not show a significant benefit of percutaneous coronary intervention (PCI) of the concurrent chronic total occlusion (CTO) in ST-segment elevation myocardial infarction (STEMI) patients on global left ventricular (LV) systolic function. However a possible treatment effect will be most pronounced in the CTO territory. Therefore, we aimed to study the effect of CTO PCI compared to no-CTO PCI on the recovery of regional LV function, particularly in the CTO territory...
July 19, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28723820/the-effects-of-cardiovascular-fitness-and-body-composition-on-maximal-core-temperature-in-collegiate-football-players-during-pre-season
#13
JoAnna M McClelland, Sandra Fowkes Godek, Pamela S Chlad, Deborah L Feairheller, Katherine E Morrison
This study evaluated the effects of BMI and aerobic fitness (VO2max) on maximal core temperature values (Tcmax) in 17 NCAA Division III football players during pre-season. The subjects included nine backs (BKs) and eight linemen (LM). VO2max testing was performed one week prior to pre-season. Core temperature was monitored via ingestible sensor every 10 min during practices on day 4(D1), day 5(D2), day 7(D3), and post-acclimatization on day 14(D4). Wet bulb globe temperature (WBGT) was recorded on each collection day...
July 14, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28720050/localized-prostate-cancer-and-robot-assisted-laparoscopic-radical-prostatectomy-a-retrospective-comparative-study-between-pre-and-post-operative-gleason-scores
#14
Michaël M E L Henderickx, Tim Brits, Tim Muilwijk, Thomas Adams, Hendrik Vandeursen
INTRODUCTION: To compare the pre- and post-operative Gleason scores (GS) in patients with localized prostate cancer treated with robot-assisted laparoscopic radical prostatectomy. MATERIALS AND METHODS: A single center, retrospective comparison between pre- and post-operative GS. Age, prostate volume, PSA, number of biopsies, number of positive cores, biopsy GS, cTNM, final pathology GS and pTNM of 286 patients were retrieved. They were divided into risk groups...
July 18, 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/28715794/an-introduction-to-the-emergency-department-adult-clinical-escalation-protocol-ed-ace
#15
Eoin Coughlan, Una Geary, Abel Wakai, Ronan O'Sullivan, John Browne, Eilish McAuliffe, Marie Ward, Fiona McDaid, Conor Deasy
PURPOSE OF THE STUDY: This study demonstrates how a participatory action research approach was used to address the challenge of the early and effective detection of the deteriorating patient in the ED setting. The approach enabled a systematic approach to patient monitoring and escalation of care to be developed to address the wide-ranging spectrum of undifferentiated presentations and the phases of ED care from triage to patient admission. This paper presents a longitudinal patient monitoring system, which aims to provide monitoring and escalation of care, where necessary, of adult patients from triage to admission to hospital in a manner that is feasible in the unique ED environment...
November 14, 2016: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28714662/enhancing-the-osteogenic-capability-of-core-shell-bilayered-bioceramic-microspheres-with-adjustable-biodegradation
#16
Xiurong Ke, Chen Zhuang, Xianyan Yang, Jia Fu, Sanzhong Xu, Lijun Xie, Zhongru Gou, Juncheng Wang, Lei Zhang, Guojing Yang
This study describes the fabrication and biological evaluation of core-shell bilayered bioceramic microspheres with adjustable compositional distribution via a coaxial bilayer capillary system. Beyond the homogeneous hybrid composites, varying the diameter of capillary nozzles and the composition of the bioceramic slurries makes it easy to create bilayered β-tricalcium phosphate (CaP)/β-calcium silicate (CaSi) microspheres with controllable compositional distribution in the core or shell layer. Primary investigations in vitro revealed that biodegradation could be adjusted by compositional distribution or shell thickness and that poorly soluble CaP located on the shell layer of CaP or CaSi@CaP microspheres was particularly beneficial for mesenchymal stem cell adhesion and growth in the early stage, but the ion release from the CaP@CaSi exhibited a potent stimulating effect on alkaline phosphatase expression of the cells at longer times...
July 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28713971/systematic-analysis-of-lncrnas-mirnas-and-mrnas-for-the-identification-of-biomarkers-for-osteoporosis-in-the-mandible-of-ovariectomized-mice
#17
Lingyu Hao, Jiayao Fu, Yawen Tian, Junhua Wu
Osteoporosis is a complex and multifactorial disease caused by an imbalance between bone formation and resorption. Post‑menopausal women with endogenous estrogen deficiency suffer from systemic bone loss and osteoporosis, and are at high risk of this affecting the jaw bones. MicroRNAs (miRNAs or miRs) have been implicated in the mechanisms of metabolic bone diseases and are expressed at differential levels in alveolar bone following ovariectomy. In the present study, we systematically analyzed the expression profiles of miRNAs, mRNAs and long non‑coding RNA (lncRNAs) in the mandible of ovariectomized (OVX) mice...
July 10, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28713120/sealing-ability-of-esthetic-post-and-core-systems
#18
Thamer Almohareb
AIM: To review the literature on the sealing ability of esthetic post systems with different cementation techniques. BACKGROUND: An important factor for successful root canal treatment is the development of a coronal seal to the treated root canal system. Review result: The current literature describes promising results using fiber posts with a dual-cure, self-etch resin cement system. However, none of the published results describe a post system or cementation technique that achieved a homogeneous and tight coronal seal...
July 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28712632/fracture-resistance-of-endodontically-treated-teeth-restored-with-2-different-fiber-reinforced-composite-and-2-conventional-composite-resin-core-buildup-materials-an-in%C3%A2-vitro-study
#19
Ashly Mary Eapen, L Vijay Amirtharaj, Kavitha Sanjeev, Sekar Mahalaxmi
INTRODUCTION: The purpose of this in vitro study was to comparatively evaluate the fracture resistance of endodontically treated teeth restored with 2 fiber-reinforced composite resins and 2 conventional composite resin core buildup materials. METHODS: Sixty noncarious unrestored human maxillary premolars were collected, endodontically treated (except group 1, negative control), and randomly divided into 5 groups (n = 10). Group 2 was the positive control. The remaining 40 prepared teeth were restored with various direct core buildup materials as follows: group 3 teeth were restored with dual-cure composite resin, group 4 with posterior composite resin, group 5 with fiber-reinforced composite resin, and group 6 with short fiber-reinforced composite resin...
July 13, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28711646/rural-rotations-at-core-rarefied-exposure-or-real-experience
#20
Christopher Brown, Tarig Abdelrahman, Neil Patel, Awen Iorwerth, John Pollitt, Mark Holt, Wyn G Lewis
OBJECTIVE: Surgical rotations involving rural General Hospitals (rGH) are frequently associated with recruitment challenges, partly because of adverse perceptions regarding distances from social support networks and training opportunities. The aim of this study was to determine the outcomes of core surgical training rotations involving rGHs when compared with urban hospitals in a single UK Deanery. DESIGN: Online Intercollegiate Surgical Curriculum Programme portfolios from 163 core surgical trainees (CST) were examined related to postlocation, operative experience, workplace-based assessments, and academic achievement...
July 12, 2017: Journal of Surgical Education
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