Megan M Herr, George L Chen, Maureen Ross, Hillary Jacobson, Renee McKenzie, Laura Markel, Sophia R Balderman, Christine M Ho, Theresa Hahn, Philip L McCarthy
A consensus grading schema for cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) resulting from chimeric antigen receptor (CAR) T cell therapy was published in 2019. Although this consensus grading schema has been imperative in identifying and monitoring CRS and ICANS in our CAR T cell population, we observed patients exhibiting subtle neurotoxicity symptoms prior to a decrease in their immune effector cell (ICE) score, which is one component of ICANS. Because we treat grade 1 ICANS at our institution, identification of early neurotoxicity symptoms is important...
November 2020: Biology of Blood and Marrow Transplantation