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https://www.readbyqxmd.com/read/28212578/interleukin-1%C3%AE-levels-predict-long-term-mortality-and-need-for-heart-transplantation-in-ambulatory-patients-affected-by-idiopathic-dilated-cardiomyopathy
#1
Aneta Aleksova, Antonio Paolo Beltrami, Cosimo Carriere, Giulia Barbati, Pierluigi Lesizza, Martina Perrieri-Montanino, Miriam Isola, Piero Gentile, Elisabetta Salvioni, Tarcisio Not, Piergiuseppe Agostoni, Gianfranco Sinagra
AIMS: The prognostic stratification of patients with Idiopathic Dilated Cardiomyopathy (iDCM) is a difficult task. Here, we assessed the additive value of the evaluation of biomarkers of inflammasome activation and systemic inflammation for the long-term risk stratification of iDCM patients. METHODS AND RESULTS: We studied 156 ambulatory iDCM patients (mean age 58 years, 77% men, 79% in NYHA class 1-2, median Left Ventricular Ejection Fraction (LVEF) 35%, mean sodium 139 mEq/L, median BNP 189 pg/mL, median IL-1 beta (IL-1β) 1...
February 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28212137/long-term-prognosis-after-acute-heart-failure-a-differential-impact-of-age-in-different-age-strata
#2
Paulo Bettencourt, Pedro Rodrigues, Helena Moreira, Pedro Marques, Patricia Lourenco
BACKGROUND: Increasing age predicts ominous prognosis in heart failure. Age influences the success of therapeutic approaches and interacts with other prognostic predictors. We aimed to study the impact of age in long-term survival in different age strata. METHODS: Patients were prospectively included in an acute heart failure registry; those with acute coronary syndromes and those with primary valvular disease were excluded. Outcome studied was all-cause mortality...
February 15, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28211605/end-stage-renal-disease-and-severe-aortic-stenosis-does-valve-replacement-improve-one-year-outcomes
#3
Jose F Condado, Aneel Maini, Bradley Leshnower, Vinod Thourani, Jessica Forcillo, Chandan Devireddy, Kreton Mavromatis, Eric L Sarin, James Stewart, Robert Guyton, Amy Simone, Patricia Keegan, Stamatios Lerakis, Peter C Block, Vasilis Babaliaros
BACKGROUND: Treatment for patients with end-stage renal disease (ESRD) and severe aortic stenosis (AS) includes balloon aortic valvuloplasty (BAV), surgical (SAVR), or transcatheter (TAVR) aortic valve replacement. We compared outcomes among these strategies. METHODS: A retrospective review of patients with ESRD undergoing treatment for severe AS between 07/2007 and 06/2015 was performed at our center. Patients were classified based on treatment: BAV-only, TAVR, or SAVR...
February 17, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28207887/platelet-monocyte-derived-and-tissue-factor-carrying-circulating-microparticles-are-related-to-acute-myocardial-infarction-severity
#4
Gemma Chiva-Blanch, Kristian Laake, Peder Myhre, Vibeke Bratseth, Harald Arnesen, Svein Solheim, Lina Badimon, Ingebjørg Seljeflot
OBJECTIVE: Circulating microparticles (cMPs) are phospholipid-rich vesicles released from cells when activated or injured, and contribute to the formation of intracoronary thrombi. Tissue factor (TF, CD142) is the main trigger of fibrin formation and TF-carrying cMPs are considered one of the most procoagulant cMPs. Similar types of atherosclerotic lesions may lead to different types of AMI, although the mechanisms behind are unresolved. Therefore, we aimed to investigate the phenotype of cMPs found in plasma of ACS patients and its relation to AMI severity and thrombotic burden...
2017: PloS One
https://www.readbyqxmd.com/read/28206674/effects-of-spinal-cord-stimulation-on-cardiac-sympathetic-nerve-activity-in-patients-with-heart-failure
#5
Jan Naar, Deborah Jaye, Cecilia Linde, Petr Neužil, Petr Doškář, Filip Málek, Frieder Braunschweig, Lars H Lund, Lars Mortensen, Bengt Linderoth, Göran Lind, Dianna Bone, Arthur J Scholte, Fred Kueffer, Jodi Koehler, Kambiz Shahgaldi, Otto Lang, Marcus Ståhlberg
BACKGROUND: Spinal cord stimulation (SCS) reduces sympathetic activity in animal models of heart failure with reduced ejection fraction (HF) but limited data exist of SCS in patients with HF. The aim of the present study was to test the primary hypothesis that SCS reduces cardiac sympathetic nerve activity in HF patients. Secondary hypotheses were that SCS improves left ventricular function and dimension, exercise capacity and clinical variables relevant to HF. METHODS: HF patients with a SCS device previously participating in the DEFEAT-HF trial were included in this crossover study with 6-week intervention periods (SCS-ON and SCS-OFF)...
February 16, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28205056/analyzing-health-related-quality-of-life-data-to-estimate-parameters-for-cost-effectiveness-models-an-example-using-longitudinal-eq-5d-data-from-the-shift-randomized-controlled-trial
#6
Alison Griffiths, Noman Paracha, Andrew Davies, Neil Branscombe, Martin R Cowie, Mark Sculpher
INTRODUCTION: The aim of this article is to discuss methods used to analyze health-related quality of life (HRQoL) data from randomized controlled trials (RCTs) for decision analytic models. The analysis presented in this paper was used to provide HRQoL data for the ivabradine health technology assessment (HTA) submission in chronic heart failure. METHODS: We have used a large, longitudinal EuroQol five-dimension questionnaire (EQ-5D) dataset from the Systolic Heart Failure Treatment with the I f Inhibitor Ivabradine Trial (SHIFT) (clinicaltrials...
February 15, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28202628/effects-of-upgrade-versus-de-novo-cardiac-resynchronization-therapy-on-clinical-response-and-long-term-survival-results-from-a-multicenter-study
#7
Mate Vamos, Julia W Erath, Zsolt Bari, Denes Vagany, Sven P Linzbach, Tatsiana Burmistrava, Carsten W Israel, Gabor Z Duray, Stefan H Hohnloser
BACKGROUND: Benefits of cardiac resynchronization therapy (CRT) on morbidity and mortality in selected patients are well known. Although the number of upgrade procedures from single- or dual-chamber devices to CRT is increasing, there are only sparse data on the outcomes of upgrade procedures compared with de novo CRT. This study aimed to evaluate clinical response and survival in patients receiving de novo versus upgrade CRT defibrillator therapy. METHODS AND RESULTS: Prospectively collected outcome data were compared in patients undergoing de novo or upgrade CRT defibrillator implantation at 3 implant centers in Germany and Hungary...
February 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28198075/exercise-induced-b-lines-identify-worse-functional-and-prognostic-stage-in-heart-failure-patients-with-depressed-left-ventricular-ejection-fraction
#8
Maria Chiara Scali, Lauro Cortigiani, Anca Simionuc, Dario Gregori, Mario Marzilli, Eugenio Picano
AIMS: Exercise stress echocardiography (ESE) is recommended by the European Society of Cardiology guidelines for the evaluation of heart failure (HF) patients. Recently, lung ultrasound (LUS) has been proposed for the assessment of extravascular lung water through B-lines. The aim of this study was to assess B-lines during ESE in HF. METHODS AND RESULTS: Standard transthoracic and LUS evaluation was performed during semi-supine ESE in 103 NYHA class I-III HF patients (76 male; mean age 64 ± 12 years) with depressed LVEF (35 ± 8%)...
February 15, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28197282/fragmented-qrs-as-a-marker-of-electrical-dyssynchrony-to-predict-inter-ventricular-conduction-defect-by-subsequent-echocardiographic-assessment-in-symptomatic-patients-of-non-ischemic-dilated-cardiomyopathy
#9
Santosh Kumar Sinha, Kush Bhagat, Mohammad Asif, Karandeep Singh, Mohit Sachan, Vikas Mishra, Nasar Afdaali, Mukesh Jitendra Jha, Ashutosh Kumar, Shravan Singh, Rupesh Sinha, Dibbendhu Khanra, Ramesh Thakur, Chandra Mohan Varma, Vinay Krishna, Umeshwar Pandey
BACKGROUND: Left ventricular (LV) dyssynchrony frequently occurs in patients with heart failure (HF). QRS ≥ 120 ms is a surrogate marker of electrical dyssynchrony, which occurs in only 30% of HF patients. In contrary, in those with normal QRS (nQRS) duration, LV dyssynchrony has been reported in 20-50%. This study was carried out to investigate the role of fragmented QRS (fQRS) on the surface electrocardiography (ECG) as a marker of electrical dyssynchrony to predict the presence of significant intraventricular dyssynchrony (IVD) by subsequent echocardiographic assessment...
August 2016: Cardiology Research
https://www.readbyqxmd.com/read/28197269/measuring-b-type-natriuretic-peptide-from-capillary-blood-or-venous-sample-is-it-the-same
#10
Renato De Vecchis, Carmelina Ariano
BACKGROUND: In recent years, several systems have been implemented to achieve quick and non-invasive measurements of B-type natriuretic peptide (BNP). Among them, Alere(TM) Heart Check (AHC) BNP test represents the most recent advancement. It is a rapid point-of-care (POC) immunoassay, projected for measuring BNP directly from a capillary whole blood sample. This study aimed at comparing the analytical and clinical performances of this new POC to our reference method (Abbott Architect System)...
April 2016: Cardiology Research
https://www.readbyqxmd.com/read/28195242/the-alternative-complement-pathway-is-dysregulated-in-patients-with-chronic-heart-failure
#11
Negar Shahini, Annika E Michelsen, Per H Nilsson, Karin Ekholt, Lars Gullestad, Kaspar Broch, Christen P Dahl, Pål Aukrust, Thor Ueland, Tom Eirik Mollnes, Arne Yndestad, Mieke C Louwe
The complement system, an important arm of the innate immune system, is activated in heart failure (HF). We hypothesized that HF patients are characterized by an imbalance of alternative amplification loop components; including properdin and complement factor D and the alternative pathway inhibitor factor H. These components and the activation product, terminal complement complex (TCC), were measured in plasma from 188 HF patients and 67 age- and sex- matched healthy controls by enzyme immunoassay. Our main findings were: (i) Compared to controls, patients with HF had significantly increased levels of factor D and TCC, and decreased levels of properdin, particularly patients with advanced clinical disorder (i...
February 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28194611/using-three-dimensional-echocardiography-to-guide-left-ventricle-lead-position-in-cardiac-resynchronization-therapy-does-it-make-any-difference
#12
Haitham A Badran, John Z Kamel, Tarek R Mohamed, Mohamed A Abdelhamid
BACKGROUND: Cardiac resynchronization therapy (CRT) is an effective treatment for patients with advanced heart failure. Nearly 30% of candidates are inadequate responders. Proper patient selection, left ventricle (LV) lead placement optimization, and optimization of the programming of the CRT device are important approaches to improve outcome of CRT. We examined the role of three-dimensional (3D) echocardiography in determining the optimal LV lead position as a method of optimizing CRT response...
February 13, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28190794/a-randomized-comparative-study-on-the-efficacy-of-intracoronary-infusion-of-autologous-bone-marrow-mononuclear-cells-and-mesenchymal-stem-cells-in-patients-with-dilated-cardiomyopathy
#13
Wentao Xiao, Suping Guo, Chuanyu Gao, Guoyou Dai, Yongjv Gao, Muwei Li, Xianpei Wang, Dayi Hu
Stem cell therapy has shown therapeutic benefit in dilated cardiomyopathy (DCM), but doubt remains about the most appropriate stem cell subpopulation. The current study compared the efficacy of intracoronary administration of bone marrow mononuclear cells (BMMC) or mesenchymal stem cells (BMSC) in patients with DCM.Fifty-three patients with DCM and reduced (< 40%) left ventricular ejection fraction (LVEF), were randomized to intracoronary infusion of BMMC (BMMC group, n = 16) or BMSC (BMSC group, n = 17) or equal volume normal saline (CTRL group, n = 20)...
February 13, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28188451/patients-with-cheyne-stokes-respiration-and-heart-failure-patient-tolerance-after-three-month-discontinuation-of-treatment-with-adaptive-servo-ventilation
#14
Arild Hetland, Tøri Vigeland Lerum, Kristina H Haugaa, Thor Edvardsen
The recent SERVE HF study concluded that patients with chronic heart failure (CHF) and Cheyne-Stokes respiration (CSR) have increased mortality when treated with adaptive servo-ventilation (ASV). We, therefore, wanted to explore if these patients tolerated discontinuation of ASV treatment. The study was a prospective post-ASV treatment observational design with a 3-month follow-up period. 14 patients from our outpatient clinic, all male, were originally diagnosed with CHF and Cheyne-Stokes respiration, which is a clinical form of central sleep apnea...
February 11, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28187168/outcomes-of-ventricular-tachycardia-ablation-in-patients-with-structural-heart-disease-the-impact-of-electrical-storm
#15
Bashar Aldhoon, Dan Wichterle, Petr Peichl, Robert Čihák, Josef Kautzner
AIMS: To investigate predictors of long-term outcomes after catheter ablation (CA) for ventricular tachycardia (VT) and the impact of electrical storm (ES) prior to index ablation procedures. METHODS: We studied consecutive patients with structural heart disease and VT (n = 328; age: 63±12 years; 88% males; 72% ischaemic cardiomyopathy; LVEF: 32±12%) who had undergone CA. According to presenting arrhythmia at baseline, they were divided into ES (n = 93, 28%) and non-ES groups...
2017: PloS One
https://www.readbyqxmd.com/read/28185817/outcomes-following-melody-transcatheter-pulmonary-valve-implantation-for-right-ventricular-outflow-tract-dysfunction-in-repaired-congenital-heart-disease-first-reported-australian-single-centre-experience
#16
Ryan Markham, Abhinay Challa, Stephen Kyranis, Mugur Nicolae, Dale Murdoch, Michael Savage, Theresa Malpas, Dorothy J Radford, Christian Hamilton-Craig, Darren L Walters
BACKGROUND: Transcatheter pulmonary valve implantation (TPVI) with the Melody® transcatheter pulmonary valve (TPV) has demonstrated good haemodynamic and clinical outcomes in the treatment of right ventricular outflow tract (RVOT) conduit dysfunction in patients with repaired congenital heart disease CHD. We present the first Australian single centre experience of patients treated with Melody TPV. METHOD: A prospective, observational registry was developed to monitor clinical and haemodynamic outcomes in patients with RVOT dysfunction treated with the Melody TPV (Medtronic Inc, Minneapolis, United States)...
January 24, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28176416/association-between-demographic-organizational-clinical-and-socio-economic-characteristics-and-underutilization-of-cardiac-resynchronization-therapy-results-from-the-swedish-heart-failure-registry
#17
Lars H Lund, Frieder Braunschweig, Lina Benson, Marcus Ståhlberg, Ulf Dahlström, Cecilia Linde
AIMS: Cardiac resynchronization therapy (CRT) improves outcomes in heart failure (HF) but may be underutilized. The reasons are unknown. METHODS AND RESULTS: We linked the Swedish Heart Failure Registry to national registries with ICD-10 (International Classification of Diseases-10th Revision) co-morbidity diagnoses and demographic and socio-economic data. In patients with EF ≤39% and NYHA II-IV, we assessed prevalence of CRT indication and CRT use. In those with CRT indication, we assessed the association between 37 potential baseline covariates and CRT non-use using multivariable generalized estimating equation (GEE) models...
February 7, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28169556/blood-pressure-dynamics-during-exercise-rehabilitation-in-heart-failure-patients
#18
Idan Hecht, Michael Arad, Dov Freimark, Robert Klempfner
Background Patients suffering from heart failure (HF) may demonstrate an abnormal blood pressure response to exercise (ABPRE), which may revert to a normal one following medical treatment. It is assumed that this change correlates positively with prognosis and functional aspects. The aim of this study was to characterize patients with ABPRE and assess ABPRE normalization and the correlation with clinical and functional outcomes. Methods In the study, 651 patients with HF who underwent cardiac rehabilitation (CR) were examined...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28169216/prognostic-implication-of-post-mitraclip-vena-contracta-area-in-heart-failure-patients-with-functional-mitral-regurgitation
#19
Hannes Alessandrini, Felix Kreidel, Michael Schlüter, Christian Frerker, Tobias Schmidt, Thomas Thielsen, Ulrich Schäfer, Karl-Heinz Kuck
AIMS: Significant functional mitral regurgitation (FMR) in elderly heart-failure patients is increasingly being treated by MitraClip implantation. We sought to assess the prognostic implications of the intraprocedural assessment of vena contracta area (VCA) after MitraClip therapy in such patients. METHODS AND RESULTS: MitraClip therapy with intraprocedural assessment of VCA was performed in 97 heart-failure patients (74±10 years; 66 men; left ventricular ejection fraction [LVEF] 31±12%; 93 patients in New York Heart Association [NYHA] functional class III [n=59] or IV [n=34]; 86 patients with FMR severity 3+ [n=65] or 4+ [n=21])...
February 8, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28168785/intermediate-term-hemodynamic-effects-of-single-inferior-vena-cava-valve-implant-for-the-treatment-of-severe-tricuspid-regurgitation
#20
Val Rakita, Vladimir Lakhter, Pravin Patil, Brian P O'Neill
Severe tricuspid regurgitation (TR) remains a vastly undertreated disease, with sustained elevation of right atrial (RA) pressure directly resulting in chronic end-organ damage. Recently, bi-caval valve implantation has been shown to improve symptoms in patients with symptomatic TR who are at high risk for surgery. We present the first report of intermediate term hemodynamic effects of single inferior vena cava (IVC) valve implantation (CAVI) for treatment of severe TR. We performed CAVI on a 66-year-old female with severe TR, who suffered from repeat hospitalizations for treatment refractory NYHA class III-IV heart failure symptoms and had prohibitive operative risk...
February 7, 2017: Catheterization and Cardiovascular Interventions
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