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Chung Thong Lim, Márta Korbonits
Pituitary adenomas are the third most common central nervous system tumours and arise from the anterior pituitary within the pituitary fossa. The signs and symptoms of patients with pituitary adenomas vary from 'mass effects' caused by a large adenoma to features secondary to excess pituitary hormones produced by the functioning pituitary adenoma. Detailed histopathological assessment, based on novel classifications and the latest WHO guidelines, helps to categorise pituitary adenomas into different subtypes and identify features that, in some cases, help to predict their behaviour...
March 2, 2018: Endocrine Practice
Abbas Ali Tam, Didem Ozdemir, Cevdet Aydın, Nagihan Bestepe, Serap Ulusoy, Nuran Sungu, Reyhan Ersoy, Bekir Cakir
PURPOSE: We aimed to investigate the relation between preoperative serum thyrotrophin (TSH) and clinicopathological features in patients with papillary thyroid carcinoma (PTC) and microcarcinoma (PTMC). METHODS: Patients who underwent thyroidectomy and diagnosed to have benign nodular disease or PTC/PTMC in our clinic were evaluated retrospectively. Patients with a previous history of thyroid surgery, patients using antithyroid medications or thyroid hormone and patients with tumors known to be unresponsive to TSH were excluded...
March 2018: Endocrine
I C Dunn, P W Wilson, Y Shi, D W Burt, A S I Loudon, P J Sharp
Increased thyrotrophin-stimulating hormone β (TSHβ) expression in the pars tuberalis is assumed to be an early step in the neuroendocrine mechanism transducing photoperiodic information. The present study aimed to determine the relationship between long-photoperiod (LP) and diurnal TSHβ gene expression in the juvenile chicken by comparing LP-photostimulated birds with groups kept on a short photoperiod (SP) for 1 or 12 days. TSHβ expression increased by 3- and 23-fold after 1 and 12 days of LP-photostimulation both during the day and at night...
December 2017: Journal of Neuroendocrinology
Lei Zheng, Chunbo Zhuang, Xiaobei Wang, Liang Ming
BACKGROUND: Previous studies have demonstrated that dysfunctional regulatory T cells (Tregs) may be associated with Graves' disease (GD). In this study, we evaluated four serum Treg-associated miRNAs (miR-210, miR-182, miR-155, and miR-146a) expressions and assessed the potential of serum miRNAs as biomarkers of GD. METHODS: Foxp3 and serum miRNAs expressions both in GD patients and healthy controls were measured by RT-PCR. RESULTS: Serum miR-210 in GD patients was significantly higher than that of healthy controls (2...
February 2018: Journal of Clinical Laboratory Analysis
Awadhesh Kumar Jaiswal, Subhash Yadav, Rabi Narayan Sahu, Anant Mehrotra, Sanjay Behari, Ashok Kumar Mahapatra
OBJECTIVE: The aim was to investigate the incidence and pattern of neuroendocrine changes in cases of acute aneurysmal subarachnoid hemorrhage (SAH). MATERIALS AND METHODS: Endocrine assessment was performed in 100 consecutive cases of acute aneurysmal SAH presenting within 7 days of ictus. The gonadotropic, somatotrophic, thyrotropic, and corticotrophic axes were evaluated for their possible dysfunction. RESULTS: A total of 100 cases (38 males, 62 females; age range - 17-76 years; mean age - 43...
January 2017: Asian Journal of Neurosurgery
Renfei Wang, Jian Tan, Guizhi Zhang, Wei Zheng, Chengxia Li
Hepatic dysfunction is often observed in patients with Graves' hyperthyroidism. The aims of this study were to investigate the risk factors for hepatic dysfunction and to analyze the efficacy of I (radioactive iodine-131) treatment. In total, 2385 patients with Graves' hyperthyroidism (478 males, 1907 females; age 42.8 ± 13.5 years) were involved in our study. Of these, 1552 cases with hepatic dysfunction received I treatment. All clinical data were retrospectively reviewed to explore the risk factors associated with hepatic dysfunction using logistic regression analysis...
February 2017: Medicine (Baltimore)
Maria Angela Zaccarelli-Marino, Carmen Diva Saldiva André, Julio M Singer
Background : Primary hypothyroidism (PH) is the most common thyroid pathology. Purpose : to evaluate the impact of public disclosure of an unexpected number of PH cases on the frequency of patients seeking medical evaluation for endocrinological diseases. Methods : data on 6306 subjects (3356 living in the surroundings of a petrochemical complex and 2950 in a control region) were collected over a 15-year time span. Thyroid function was determined by serum levels of triiodothyronine, thyroxine, free thyroxine and thyrotrophin...
November 22, 2016: International Journal of Environmental Research and Public Health
X Fu, H Xia, H Mao, S Zhao, Z Wang
OBJECTIVE: The purpose of this study was to investigate the effect of glycaemic control on subclinical hypothyroidism (SCH) in Chinese type 2 diabetic patients. METHODS: The study included 476 diabetic patients with SCH admitted for treatment of type 2 diabetes. The controls were selected euthyroid patients with similar characteristics regarding [age, body mass index (BMI), gender, previous hypertension or duration of diabetes, and smoke]. Total cholesterol (TC), LDL cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), the homeostatic model assessment of insulin resistance ratio (HOMA-IR), fasting plasma glucose, hemoglobin A1c (HbA1c), as well as plasma levels of thyrotrophin, and free thyroxine (FT4) were assessed at baseline and after 6 months of glycaemic control treatment...
December 2016: Journal of Endocrinological Investigation
Rong Zeng, Tao Shou, Kun-Xian Yang, Tao Shen, Jin-Ping Zhang, Rong-Xia Zuo, Yong-Qing Zheng, Xin-Ming Yan
OBJECTIVE: This study investigated clinical and pathological characteristics and risk factors in papillary thyroid carcinoma (PTC) patients' native to Yunnan plateau in southwestern China. METHODS: Clinical data from 1,198 patients diagnosed with PTC (n=578) and control subjects (n=620) with benign thyroid disease (ie, thyroid nodule disease, benign thyroid diseases [BTD]) in Yunnan province were analyzed retrospectively. RESULTS: The mean patient age was lower for PTC than for BTD...
2016: Therapeutics and Clinical Risk Management
Sule Temizkan, Bilgken Balaforlou, Aysenur Ozderya, Mehmet Avci, Kadriye Aydin, Selin Karaman, Mehmet Sargin
OBJECTIVE: To investigate whether thyroid function in the euthyroid range and thyroid autoimmunity status would affect metabolic measures in individuals with obesity. DESIGN: Cross-sectional. PATIENTS: We retrospectively evaluated 5300 consecutive obese (BMI ≥30 kg/m(2) ) subjects attending the Obesity Outpatient Clinic. Subjects with overt or subclinical thyroid disease, diabetes mellitus, chronic disease or using any medication were excluded...
October 2016: Clinical Endocrinology
Lin Liu, Hongwen Lu, Yang Liu, Changshan Liu, Chu Xun
The aim of the present study was to monitor long term antithyroid drug treatments and to identify prognostic factors for Graves' disease (GD). A total of 306 patients with GD who were referred to the Endocrinology Clinic at Weifang People's Hospital (Weifang, China) between August 2005 and June 2009 and treated with methimazole were included in the present study. Following treatment, patients were divided into non-remission, including recurrence and constant treatment subgroups, and remission groups. Various prognosis factors were analyzed and compared, including: Patient age, gender, size of thyroid prior to and following treatment, thyroid hormone levels, disease relapse, hypothyroidism and drug side-effects, and states of thyrotropin suppression were observed at 3, 6 and 12 months post-treatment...
April 2016: Experimental and Therapeutic Medicine
J Yang, X Zhang, Z Liu, Z Yuan, Y Song, S Shao, X Zhou, H Yan, Q Guan, L Gao, H Zhang, J Zhao
Emerging evidence shows that elevated cholesterol levels are detrimental to health. However, it is unclear whether there is an association between cholesterol and the pituitary. We investigated the effects of a high-cholesterol diet on pituitary hormones using in vivo animal studies and an epidemiological study. In the animal experiments, rats were fed a high-cholesterol or control diet for 28 weeks. In rats fed the high-cholesterol diet, serum levels of thyroid-stimulating hormone (TSH; also known as thyrotrophin), luteinising hormone (LH) and follicle-stimulating hormone (FSH) produced by the basophilic cells of the anterior pituitary were elevated in a time-dependent manner...
March 2016: Journal of Neuroendocrinology
Thirunavukkarasu Yoganathan, Manjula Hettiarachchi, Vasanthy Arasaratnam, Chandrani Liyanage
INTRODUCTION: Iodine status of pregnant women and their newborns have not been studied in Jaffna District, Sri Lanka. This study was planned to assess the maternal iodine status and thyroid function at the third trimester of gestation and the thyrotrophin level of their neonate. METHODS: Four hundred and seventy-seven pregnant women and their newborns were randomly selected among six Medical Officers of Health Divisions out of 12 in Jaffna District, Sri Lanka. Maternal thyroid stimulating hormone (TSH), free thyroxine (fT4), thyroglobulin (Tg), urinary iodine levels, and the neonatal thyrotrophin (nTSH) level were assessed...
November 2015: Indian Journal of Endocrinology and Metabolism
Ahmet Dirikoc, Sefika Burcak Polat, Zuhal Kandemir, Cevdet Aydin, Didem Ozdemir, Fatma Dilek Dellal, Reyhan Ersoy, Bekir Cakir
OBJECTIVE: When a scintigraphically autonomous nodule does not produce thyroid hormones enough to suppress serum thyrotrophin, it is generally defined as nontoxic autonomous nodule. In this study, we aimed to compare clinical and ultrasonographical (US) features and cytological and histopathological results of toxic and nontoxic autonomous nodules. METHODS: Patients who underwent thyroidectomy and were evaluated with technetium-99m-pertechnetate scintigraphy preoperatively in our institution between May 2008 and December 2014 were identified from medical records...
December 2015: Annals of Nuclear Medicine
Onyebuchi Okosieme, Jackie Gilbert, Prakash Abraham, Kristien Boelaert, Colin Dayan, Mark Gurnell, Graham Leese, Christopher McCabe, Petros Perros, Vicki Smith, Graham Williams, Mark Vanderpump
The management of primary hypothyroidism with levothyroxine (L-T4) is simple, effective and safe, and most patients report improved well-being on initiation of treatment. However, a proportion of individuals continue to suffer with symptoms despite achieving adequate biochemical correction. The management of such individuals has been the subject of controversy and of considerable public interest. The American Thyroid Association (ATA) and the European Thyroid Association (ETA) have recently published guidelines on the diagnosis and management of hypothyroidism...
June 2016: Clinical Endocrinology
Basil Rapoport, Holly A Aliesky, Bianca Banuelos, Chun-Rong Chen, Sandra M McLachlan
Abs that stimulate the thyrotropin receptor (TSHR), the cause of Graves' hyperthyroidism, only develop in humans. TSHR Abs can be induced in mice by immunization, but studying pathogenesis and therapeutic intervention requires a model without immunization. Spontaneous, iodine-accelerated, thyroid autoimmunity develops in NOD.H2(h4) mice associated with thyroglobulin and thyroid-peroxidase, but not TSHR, Abs. We hypothesized that transferring the human TSHR A-subunit to NOD.H2(h4) mice would result in loss of tolerance to this protein...
May 1, 2015: Journal of Immunology: Official Journal of the American Association of Immunologists
Hee-Won Moon, Hee-Jung Chung, Mina Hur, Yeo-Min Yun
OBJECTIVE: There is increasing interest in the role of vitamin D (vitD) during pregnancy. We prospectively evaluated the vitD status in Korean pregnant women and evaluated the levels of vitD according to thyroid-specific autoimmunity during pregnancy. METHODS: We included pregnant 531 women who visited for prenatal care and 238 age-matched, non-pregnant women as a control population. The levels of thyrotropin, FT4, thyroid peroxidase (TPO), thyroglobulin (Tg) antibody (Ab) and 25-hydroxy vitamin D [25(OH)D] were measured by electrochemiluminescence immunoassays...
2015: Journal of Maternal-fetal & Neonatal Medicine
Hong Zhang, Lingyun Liang, Zhongjian Xie
OBJECTIVE: Vitamin D deficiency is reportedly linked to a variety of autoimmune diseases. However, the relationship between thyroid autoimmunity in Graves disease (GD) and vitamin D deficiency is unclear. The goal of this study was to determine whether increased thyroid hormone autoantibody titer is associated with vitamin D deficiency in GD patients. METHODS: A total of 70 patients with GD and 70 matched control subjects were recruited to our study. The levels of 25-hydroxyvitamin D (25[OH]D), calcium, parathyroid hormone (PTH), free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), thyrotropin-receptor antibody (TRAb), thyroid-peroxidase antibody (TPOAb), and thyroglobulin antibody (TGAb) in serum collected from these patients and controls were examined...
March 2015: Endocrine Practice
Paola Triggianese, Carlo Perricone, Roberto Perricone, Caterina De Carolis
PROBLEM: An association between serum prolactin (PRL) and peripheral blood natural killer (NK) cells has been described in healthy women. We explored for the first time the PRL response to the thyrotrophin-releasing hormone (TRH) test and the association between PRL and NK cells in women with reproductive failure. METHODS: A total of 130 women [31 primary infertility, 69 recurrent spontaneous abortion (RSA), and 30 fertile women] were evaluated by a TRH test to analyze the following: basal PRL (bPRL), peak-time PRL, PRL absolute and relative increase, decline-time PRL...
January 2015: American Journal of Reproductive Immunology: AJRI
I Sotelo-Rivera, L Jaimes-Hoy, A Cote-Vélez, C Espinoza-Ayala, J-L Charli, P Joseph-Bravo
The activity of the hypothalamic-pituitary-thyroid (HPT) axis is rapidly adjusted by energy balance alterations. Glucocorticoids can interfere with this activity, although the timing of this interaction is unknown. In vitro studies indicate that, albeit incubation with either glucocorticoid receptor (GR) agonists or protein kinase A (PKA) activators enhances pro-thyrotrophin-releasing hormone (pro-TRH) transcription, co-incubation with both stimuli reduces this enhancement. In the present study, we used primary cultures of hypothalamic cells to test whether the order of these stimuli alters the cross-talk...
December 2014: Journal of Neuroendocrinology
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