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X Fu, H Xia, H Mao, S Zhao, Z Wang
OBJECTIVE: The purpose of this study was to investigate the effect of glycaemic control on subclinical hypothyroidism (SCH) in Chinese type 2 diabetic patients. METHODS: The study included 476 diabetic patients with SCH admitted for treatment of type 2 diabetes. The controls were selected euthyroid patients with similar characteristics regarding [age, body mass index (BMI), gender, previous hypertension or duration of diabetes, and smoke]. Total cholesterol (TC), LDL cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), the homeostatic model assessment of insulin resistance ratio (HOMA-IR), fasting plasma glucose, hemoglobin A1c (HbA1c), as well as plasma levels of thyrotrophin, and free thyroxine (FT4) were assessed at baseline and after 6 months of glycaemic control treatment...
July 30, 2016: Journal of Endocrinological Investigation
Rong Zeng, Tao Shou, Kun-Xian Yang, Tao Shen, Jin-Ping Zhang, Rong-Xia Zuo, Yong-Qing Zheng, Xin-Ming Yan
OBJECTIVE: This study investigated clinical and pathological characteristics and risk factors in papillary thyroid carcinoma (PTC) patients' native to Yunnan plateau in southwestern China. METHODS: Clinical data from 1,198 patients diagnosed with PTC (n=578) and control subjects (n=620) with benign thyroid disease (ie, thyroid nodule disease, benign thyroid diseases [BTD]) in Yunnan province were analyzed retrospectively. RESULTS: The mean patient age was lower for PTC than for BTD...
2016: Therapeutics and Clinical Risk Management
Sule Temizkan, Bilgken Balaforlou, Aysenur Ozderya, Mehmet Avci, Kadriye Aydin, Selin Karaman, Mehmet Sargin
OBJECTIVE: To investigate whether thyroid function in the euthyroid range and thyroid autoimmunity status would affect metabolic measures in individuals with obesity. DESIGN: Cross-sectional. PATIENTS: We retrospectively evaluated 5300 consecutive obese (BMI ≥30 kg/m(2) ) subjects attending the Obesity Outpatient Clinic. Subjects with overt or subclinical thyroid disease, diabetes mellitus, chronic disease or using any medication were excluded...
October 2016: Clinical Endocrinology
Lin Liu, Hongwen Lu, Yang Liu, Changshan Liu, Chu Xun
The aim of the present study was to monitor long term antithyroid drug treatments and to identify prognostic factors for Graves' disease (GD). A total of 306 patients with GD who were referred to the Endocrinology Clinic at Weifang People's Hospital (Weifang, China) between August 2005 and June 2009 and treated with methimazole were included in the present study. Following treatment, patients were divided into non-remission, including recurrence and constant treatment subgroups, and remission groups. Various prognosis factors were analyzed and compared, including: Patient age, gender, size of thyroid prior to and following treatment, thyroid hormone levels, disease relapse, hypothyroidism and drug side-effects, and states of thyrotropin suppression were observed at 3, 6 and 12 months post-treatment...
April 2016: Experimental and Therapeutic Medicine
J Yang, X Zhang, Z Liu, Z Yuan, Y Song, S Shao, X Zhou, H Yan, Q Guan, L Gao, H Zhang, J Zhao
Emerging evidence shows that elevated cholesterol levels are detrimental to health. However, it is unclear whether there is an association between cholesterol and the pituitary. We investigated the effects of a high-cholesterol diet on pituitary hormones using in vivo animal studies and an epidemiological study. In the animal experiments, rats were fed a high-cholesterol or control diet for 28 weeks. In rats fed the high-cholesterol diet, serum levels of thyroid-stimulating hormone (TSH; also known as thyrotrophin), luteinising hormone (LH) and follicle-stimulating hormone (FSH) produced by the basophilic cells of the anterior pituitary were elevated in a time-dependent manner...
March 2016: Journal of Neuroendocrinology
Thirunavukkarasu Yoganathan, Manjula Hettiarachchi, Vasanthy Arasaratnam, Chandrani Liyanage
INTRODUCTION: Iodine status of pregnant women and their newborns have not been studied in Jaffna District, Sri Lanka. This study was planned to assess the maternal iodine status and thyroid function at the third trimester of gestation and the thyrotrophin level of their neonate. METHODS: Four hundred and seventy-seven pregnant women and their newborns were randomly selected among six Medical Officers of Health Divisions out of 12 in Jaffna District, Sri Lanka. Maternal thyroid stimulating hormone (TSH), free thyroxine (fT4), thyroglobulin (Tg), urinary iodine levels, and the neonatal thyrotrophin (nTSH) level were assessed...
November 2015: Indian Journal of Endocrinology and Metabolism
Ahmet Dirikoc, Sefika Burcak Polat, Zuhal Kandemir, Cevdet Aydin, Didem Ozdemir, Fatma Dilek Dellal, Reyhan Ersoy, Bekir Cakir
OBJECTIVE: When a scintigraphically autonomous nodule does not produce thyroid hormones enough to suppress serum thyrotrophin, it is generally defined as nontoxic autonomous nodule. In this study, we aimed to compare clinical and ultrasonographical (US) features and cytological and histopathological results of toxic and nontoxic autonomous nodules. METHODS: Patients who underwent thyroidectomy and were evaluated with technetium-99m-pertechnetate scintigraphy preoperatively in our institution between May 2008 and December 2014 were identified from medical records...
December 2015: Annals of Nuclear Medicine
Onyebuchi Okosieme, Jackie Gilbert, Prakash Abraham, Kristien Boelaert, Colin Dayan, Mark Gurnell, Graham Leese, Christopher McCabe, Petros Perros, Vicki Smith, Graham Williams, Mark Vanderpump
The management of primary hypothyroidism with levothyroxine (L-T4) is simple, effective and safe, and most patients report improved well-being on initiation of treatment. However, a proportion of individuals continue to suffer with symptoms despite achieving adequate biochemical correction. The management of such individuals has been the subject of controversy and of considerable public interest. The American Thyroid Association (ATA) and the European Thyroid Association (ETA) have recently published guidelines on the diagnosis and management of hypothyroidism...
June 2016: Clinical Endocrinology
Basil Rapoport, Holly A Aliesky, Bianca Banuelos, Chun-Rong Chen, Sandra M McLachlan
Abs that stimulate the thyrotropin receptor (TSHR), the cause of Graves' hyperthyroidism, only develop in humans. TSHR Abs can be induced in mice by immunization, but studying pathogenesis and therapeutic intervention requires a model without immunization. Spontaneous, iodine-accelerated, thyroid autoimmunity develops in NOD.H2(h4) mice associated with thyroglobulin and thyroid-peroxidase, but not TSHR, Abs. We hypothesized that transferring the human TSHR A-subunit to NOD.H2(h4) mice would result in loss of tolerance to this protein...
May 1, 2015: Journal of Immunology: Official Journal of the American Association of Immunologists
Hee-Won Moon, Hee-Jung Chung, Mina Hur, Yeo-Min Yun
OBJECTIVE: There is increasing interest in the role of vitamin D (vitD) during pregnancy. We prospectively evaluated the vitD status in Korean pregnant women and evaluated the levels of vitD according to thyroid-specific autoimmunity during pregnancy. METHODS: We included pregnant 531 women who visited for prenatal care and 238 age-matched, non-pregnant women as a control population. The levels of thyrotropin, FT4, thyroid peroxidase (TPO), thyroglobulin (Tg) antibody (Ab) and 25-hydroxy vitamin D [25(OH)D] were measured by electrochemiluminescence immunoassays...
2015: Journal of Maternal-fetal & Neonatal Medicine
Hong Zhang, Lingyun Liang, Zhongjian Xie
OBJECTIVE: Vitamin D deficiency is reportedly linked to a variety of autoimmune diseases. However, the relationship between thyroid autoimmunity in Graves disease (GD) and vitamin D deficiency is unclear. The goal of this study was to determine whether increased thyroid hormone autoantibody titer is associated with vitamin D deficiency in GD patients. METHODS: A total of 70 patients with GD and 70 matched control subjects were recruited to our study. The levels of 25-hydroxyvitamin D (25[OH]D), calcium, parathyroid hormone (PTH), free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), thyrotropin-receptor antibody (TRAb), thyroid-peroxidase antibody (TPOAb), and thyroglobulin antibody (TGAb) in serum collected from these patients and controls were examined...
March 2015: Endocrine Practice
Paola Triggianese, Carlo Perricone, Roberto Perricone, Caterina De Carolis
PROBLEM: An association between serum prolactin (PRL) and peripheral blood natural killer (NK) cells has been described in healthy women. We explored for the first time the PRL response to the thyrotrophin-releasing hormone (TRH) test and the association between PRL and NK cells in women with reproductive failure. METHODS: A total of 130 women [31 primary infertility, 69 recurrent spontaneous abortion (RSA), and 30 fertile women] were evaluated by a TRH test to analyze the following: basal PRL (bPRL), peak-time PRL, PRL absolute and relative increase, decline-time PRL...
January 2015: American Journal of Reproductive Immunology: AJRI
I Sotelo-Rivera, L Jaimes-Hoy, A Cote-Vélez, C Espinoza-Ayala, J-L Charli, P Joseph-Bravo
The activity of the hypothalamic-pituitary-thyroid (HPT) axis is rapidly adjusted by energy balance alterations. Glucocorticoids can interfere with this activity, although the timing of this interaction is unknown. In vitro studies indicate that, albeit incubation with either glucocorticoid receptor (GR) agonists or protein kinase A (PKA) activators enhances pro-thyrotrophin-releasing hormone (pro-TRH) transcription, co-incubation with both stimuli reduces this enhancement. In the present study, we used primary cultures of hypothalamic cells to test whether the order of these stimuli alters the cross-talk...
December 2014: Journal of Neuroendocrinology
E Kilburn-Watt, R B Banati, K A Keay
The co-morbidity of mood disturbance, in a proportion of patients, is now described across a wide range of chronic disease states. Similarly, a 'Low Thyroid Syndrome' is also reported in a proportion of individuals with chronic diseases. Here, we report on central changes in an animal model of inflammatory stress in which altered social behaviour, representing social disability, persists in a sub-group of rats following injury. We showed in an earlier study that rats with social disability following injury have significantly decreased peripheral thyroid hormones, with no increase in Thyroid Stimulating Hormone (TSH)...
August 2014: Brain Research Bulletin
N Inoue, M Watanabe, N Ishido, Y Katsumata, T Kagawa, Y Hidaka, Y Iwatani
Vitamin D is a multi-functional immune regulator, and a low serum concentration of vitamin D promotes autoimmune inflammation. In this study, we evaluate the association between the prognosis of autoimmune thyroid disease (AITD) and the functional polymorphisms of genes that regulate vitamin D metabolism. For 139 Graves' disease (GD) patients, 116 Hashimoto's disease (HD) patients and 76 control subjects, we genotyped the following polymorphisms using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP): vitamin D receptor (VDR): rs731236, rs7975232, rs2228570 and rs1544410; group-specific component (GC): rs7041 and rs4588; and CYP2R1: rs10741657...
November 2014: Clinical and Experimental Immunology
L Monen, S M Kuppens, T H Hasaart, H Wijnen, V J Pop
BACKGROUND: Maternal thyroid dysfunction is of known influence on pregnancies in the preterm period. However little is known about its effect on term and post term pregnancies. Meconium stained amniotic fluid (MSAF) is known to occur preferentially in (post)term pregnancies. AIMS: To assess a possible independent relation between maternal thyroid function and MSAF. STUDY DESIGN AND SUBJECTS: 1051 women, in whom thyroid function was assessed at each trimester, were followed prospectively (delivery ≥37weeks)...
July 2014: Early Human Development
Wilmar M Wiersinga, Leonidas Duntas, Valentin Fadeyev, Birte Nygaard, Mark P J Vanderpump
BACKGROUND: Data suggest symptoms of hypothyroidism persist in 5-10% of levothyroxine (L-T4)-treated hypothyroid patients with normal serum thyrotrophin (TSH). The use of L-T4 + liothyronine (L-T3) combination therapy in such patients is controversial. The ETA nominated a task force to review the topic and formulate guidelines in this area. METHODS: Task force members developed a list of relevant topics. Recommendations on each topic are based on a systematic literature search, discussions within the task force, and comments from the European Thyroid Association (ETA) membership at large...
July 2012: European Thyroid Journal
Yanling Wang, Wei Sun, Xiaonan Zhu, Yongqin Cao, Pengfei Ge
OBJECTIVE: To assess the iodine nutrition and thyroid function of pregnant women during different periods of pregnancy, to provide evidence for guiding iodine supplementation for them. METHODS: A cross-sectional survey was performed in 215 pregnant women in Yongjing couty from May to June 2013. Samples of blood and random urine were collected, and serum thyrotrophin (TSH), free triiodothyronine (FT3), free thyroxine (FT4), anti-thyroid peroxidase (anti-TPO), antithyroglobulin ( anti-TG)and urinary iodine were measured...
January 2014: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
Yanting Ren, Qingzhen Jia, Xiangdong Zhang, Baisuo Guo, Xinping Wen, Fengfeng Zhang, Yongping Wang, Juanjuan Wang
OBJECTIVE: To understand the prevalence of thyroid diseases and its influencing factors of iodine on thyroid gland function and autoimmune among fertile women in different iodine intake areas. METHODS: Cross-sectional method was used for descriptive epidemiology. 236 women aged 19 to 45 years were sampled in 2011, in Shanxi province. Questionnaire was used to include general data on place, name, age etc. Sample of water from home, one time random urine sample and venous blood were collected to test the iodine contents using arsenic and cerium catalysis spectrophotometric methods...
January 2014: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
Bu B Yeap, Leon Flicker
Older men have lower circulating testosterone (T) and insulin-like growth factor-I (IGF-I) but higher levels of thyrotrophin (TSH) compared with younger men, and exhibit poorer health. Whether age-associated differences in hormone levels are causally related to cardiovascular disease, or are biomarkers reflecting accumulated ill-health remains under debate. Lower T levels are associated with aortic, peripheral vascular, and cardiovascular disease in middle-aged and older men. In some but not all studies, lower levels of T predict increased incidence of cardiovascular events and mortality...
May 2014: Journal of the American Medical Directors Association
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