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https://www.readbyqxmd.com/read/29928559/clinical-etiological-anatomical-and-bacteriological-study-of-diabetic-foot-patients-results-of-a-single-center-study
#1
Ashwinikumar Patil, Datta More, Anant Patil, Kishor A Jadhav, Myriam E Vijil Mejia, Suresh S Patil
OBJECTIVE: To examine the clinical pattern of foot-related complications in type 2 diabetes patients. MATERIAL AND METHODS: A cross-sectional study was conducted among indoor, adult type 2 diabetes patients with risk factors for diabetic foot complications. The diabetic neuropathy symptom score (DNSS), Doppler scanning, ankle brachial pressure index (ABPI) assessment, neuropathy assessment, neuropathic disability score (NDS), biothesiometry evaluation, and bacteriological examination was performed...
April 18, 2018: Curēus
https://www.readbyqxmd.com/read/29924718/case-255-foot-binding
#2
Adeline Mei-Yen Yong, Paul A Tambyah
History A 99-year-old Chinese-Indonesian woman with a longstanding history of diabetes mellitus was admitted for chest infection and was incidentally found to have bilateral deformed feet. She was otherwise asymptomatic and could ambulate independently. Photographs and radiographs of the feet were obtained.
July 2018: Radiology
https://www.readbyqxmd.com/read/29923767/the-protective-role-of-trpc6-knockout-in-the-progression-of-diabetic-kidney-disease
#3
Denisha Spires, Daria V Ilatovskaya, Vladislav Levchenko, Paula E North, Aron M Geurts, Oleg Palygin, Alexander Staruschenko
Diabetic kidney disease (DKD) is a chronic kidney pathology that leads to end stage renal disease. Previous studies from our laboratory indicate that there is an association between the development of DKD and the TRPC6 channel. Trpc6 expression and activity was increased in the streptozotocin (STZ)-treated Dahl Salt-sensitive (SS) rat, an established model of type 1 diabetes. Here, using a Trpc6 knock-out created on the SS rat background (SSTRPC6-/- ), we test the hypothesis that the absence of Trpc6 will protect podocytes and kidney function during the development of DKD...
June 20, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29923533/diabetes-self-care-activities-among-adults-20-years-and-above-residing-in-a-resettlement-colony-in-east-delhi
#4
Anu Mohandas, S K Bhasin, Madhu Upadhyay, S V Madhu
Background: Self-care activities are the cornerstone of diabetes care that ensures patients participation to achieve optimal glycemic control and to prevent complications. Objective: The aim of this study is to find the level of self-care activities among diabetics aged ≥20 years residing in a resettlement colony in East Delhi and its association with sociodemographic factors, disease, and treatment profile. Methods: Using cross-sectional survey, 168 known diabetic patients were selected from Nand Nagri, a resettlement colony in East Delhi...
April 2018: Indian Journal of Public Health
https://www.readbyqxmd.com/read/29922458/neuroarthropathy-in-diabetes-pathogenesis-of-charcot-arthropathy
#5
S E Johnson-Lynn, A W McCaskie, A P Coll, A H N Robinson
Charcot neuroarthropathy is a rare but serious complication of diabetes, causing progressive destruction of the bones and joints of the foot leading to deformity, altered biomechanics and an increased risk of ulceration. Management is complicated by a lack of consensus on diagnostic criteria and an incomplete understanding of the pathogenesis. In this review, we consider recent insights into the development of Charcot neuroarthropathy. It is likely to be dependent on several interrelated factors which may include a genetic pre-disposition in combination with diabetic neuropathy...
May 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29916424/footwear-in-the-causation-and-prevention-of-foot-ulcers-in-diabetes-mellitus
#6
Ramaswamy Premkumar, Pitchaimuthu Rajan, Jeeva Rima, Joseph Richard
Background.: Inappropriate footwear may be a major cause of foot ulceration among patients with diabetic neuropathy in India. No study has specifically examined the types of footwear or its components in patients with diabetes mellitus and their role in causing foot ulcers. We analysed the role of commonly used footwear in India in inducing first foot ulcers (FFU) in people with diabetes. Methods.: Of 4800 patients with diabetes attending our centre over 1 year, 301 had FFU from different causes...
September 2017: National Medical Journal of India
https://www.readbyqxmd.com/read/29916286/chinese-medicine-ulcer-oil-promotes-the-healing-of-diabetic-foot-ulcers
#7
Hui Jia, Bohua Yang, Youshan Li, Chen Liang, Haibin Lu, Dongyang Lin, Ju Shang
Objective This study aimed to investigate the mechanism by which Chinese herbal medicine ulcer oil (UO) accelerates ulcer healing in a diabetic ulcer rat model. Methods Sprague Dawley rats were allocated at random into four groups: a control group, a positive control group (PC), a UO treatment group and an ethacridine lactate solution treatment group. Subcutaneous tissue was surgically removed from the rats on days 3, 7 and 14. The levels of protein phosphotyrosine phosphatase 1B (PTP1B), vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF) and advanced glycation end products (AGEs) were detected using western blot analysis...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29914830/clinical-factors-that-influence-the-cellular-responses-of-saphenous-veins-used-for-arterial-bypass
#8
Michael Sobel, Shinsuke Kikuchi, Lihua Chen, Gale L Tang, Tom N Wight, Richard D Kenagy
OBJECTIVE: When an autogenous vein is harvested and used for arterial bypass, it suffers physical and biologic injuries that may set in motion the cellular processes that lead to wall thickening, fibrosis, stenosis, and ultimately graft failure. Whereas the injurious effects of surgical preparation of the vein conduit have been extensively studied, little is known about the influence of the clinical environment of the donor leg from which the vein is obtained. METHODS: We studied the cellular responses of fresh saphenous vein samples obtained before implantation in 46 patients undergoing elective lower extremity bypass surgery...
June 15, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29914816/analysis-of-recurrent-ulcerations-at-a-multidisciplinary-diabetic-foot-unit-after-implementation-of-a-comprehensive-foot-care-program
#9
Sara Jiménez, José Antonio Rubio, Julia Álvarez, José Luis Lázaro-Martínez
BACKGROUND AND OBJECTIVE: The aim of this study was to assess the risk factors associated to recurrent diabetic foot ulcers after implementing a new preventive comprehensive foot care (CFC) program carried out by a podiatrist and an endocrinologist at a multidisciplinary diabetic foot unit (MDFU) and its potential impact in decreasing recurrent ulcers. MATERIAL AND METHODS: A retrospective cohort study including consecutive patients who attended the MDFU for the first time from 2008 to 2014 complaining of a diabetic foot ulcer that finally healed...
June 15, 2018: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29914066/connexin-43-based-therapeutics-for-dermal-wound-healing
#10
REVIEW
Jade Montgomery, Gautam S Ghatnekar, Christina L Grek, Kurtis E Moyer, Robert G Gourdie
The most ubiquitous gap junction protein within the body, connexin 43 (Cx43), is a target of interest for modulating the dermal wound healing response. Observational studies found associations between Cx43 at the wound edge and poor healing response, and subsequent studies utilizing local knockdown of Cx43 found improvements in wound closure rate and final scar appearance. Further preclinical work conducted using Cx43-based peptide therapeutics, including alpha connexin carboxyl terminus 1 (αCT1), a peptide mimetic of the Cx43 carboxyl terminus, reported similar improvements in wound healing and scar formation...
June 15, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29912253/-prevalence-and-susceptibility-pattern-of-bacteria-isolated-from-infected-chronic-wounds-in-adult-patients
#11
Víctor Silva, Alicia Marcoleta, Viviana Silva, Dángelo Flores, Teresa Aparicio, Isabel Aburto, Cecilia Latrach, Naldy Febré
BACKGROUND: Chronic wounds are considered a public health problem that may be complicated by bacterial infections, mainly caused by resistant strains. AIM: To study the bacteria prevalence and antimicrobial susceptibility in samples from adult patients with chronic wounds. METHODS: Patients treated at National Institute of Wounds Foundation between May and July 2014, with chronic ulcers in lower extremities with clinical inflammatory signs were recluted...
April 2018: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29912162/regulation-and-function-of-tmem16f-in-renal-podocytes
#12
Laura K Schenk, Jiraporn Ousingsawat, Boris V Skryabin, Rainer Schreiber, Hermann Pavenstädt, Karl Kunzelmann
The Ca2+ -activated phospholipid scramblase and ion channel TMEM16F is expressed in podocytes of renal glomeruli. Podocytes are specialized cells that form interdigitating foot processes as an essential component of the glomerular filter. These cells, which participate in generation of the primary urine, are often affected during primary glomerular diseases, such as glomerulonephritis and secondary hypertensive or diabetic nephropathy, which always leads to proteinuria. Because the function of podocytes is known to be controlled by intracellular Ca2+ signaling, it is important to know about the role of Ca2+ -activated TMEM16F in these cells...
June 18, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29910628/autoamputation-of-diabetic-toe-with-dry-gangrene-a-myth-or-a-fact
#13
REVIEW
Abdullah Al Wahbi
Diabetes is associated with various complications and reduced quality of life. Of the many complications, some are life-threatening. Among these, foot complications remain an important concern. The major foot complications include foot ulceration, cellulitis, abscess, wet gangrene, dry gangrene, and necrotizing fasciitis, with different pathophysiological concepts behind each of them. Gangrene occurs due to reduced blood supply in the body tissues that leads to necrosis. This condition may arise because of an injury, infection, or other health conditions, majorly diabetes...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
https://www.readbyqxmd.com/read/29909681/is-it-necessary-to-change-instruments-between-sampling-sites-when-taking-multiple-tissue-specimens-in-musculoskeletal-infections
#14
D Makki, S Abdalla, T A El Gamal, D Harvey, G Jackson, S Platt
Introduction Surgical debridement of orthopaedic infections allows biopsy for microbiology and facilitates successful treatment. It is recommended that biopsy instruments are changed when taking multiple samples. This study compared assessed cross-contamination between biopsy sites when using same instruments to take tissue samples from multiple sites. Materials and methods During the surgical debridement, we defined five sampling sites and marked them with diathermy. Two sampling techniques were performed on same patient to minimise any potential bias arising from the type of host and the severity of infection...
June 18, 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29909087/critical-appraisal-of-the-quality-of-evidence-addressing-the-diagnosis-prognosis-and-management-of-peripheral-artery-disease-in-patients-with-diabetic-foot-ulceration
#15
Stephen R Ali, Baris A Ozdemir, Robert J Hinchliffe
AIMS: There is a paucity of robust evidence on prevention and management of diabetic foot ulcers (DFUs) to inform treatment. This study appraises the current quality of the evidence addressing diagnosis, prognosis, and management of peripheral artery disease (PAD) in patients with DFUs using a newly devised 21 point scoring (TOPS) disease specific research appraisal tool published by the International Working Group on the Diabetic Foot (IWGDF) and European Wound Management Association...
June 13, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29907536/methicillin-resistant-staphylococcus-aureus-nasal-carriage-and-infection-among-patients-with-diabetic-foot-ulcer
#16
Shin-Yi Lin, Nai-Yu Lin, Yu-Yao Huang, Chi-Chun Hsieh, Yhu-Chering Huang
PURPOSE: To evaluate the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) nasal carriage in patients with diabetic foot ulcer (DFU) in Taiwan, and to assess the concordance between colonizing and clinical MRSA isolates from the patients. METHOD: A total of 354 nasal specimens were collected from 112 to 242 diabetic patients with and without foot ulcer, respectively. MRSA clinical isolates from DFU wound cultures were collected for comparison. RESULTS: Nasal carriage rate of S...
June 4, 2018: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/29907172/-nursing-care-of-a-patient-admitted-to-a-hyperbaric-chamber-for-a-chronic-wound
#17
Stéphanie Chevallier, Simon Le Nabat, Arnaud Druelle, Hugues Lefort, Jean-Éric Blatteau
The hyperbaric chamber is a particularly relevant therapy for the healing of chronic wounds such as radiation-induced wounds, ulcers, diabetic foot or osteomyelitis. This article describes the pathway of a patient with a chronic wound from the perspective of a hyperbaric medicine nurse.
June 2018: Revue de L'infirmière
https://www.readbyqxmd.com/read/29906277/can-ultrasound-measures-of-intrinsic-foot-muscles-and-plantar-soft-tissues-predict-future-diabetes-related-foot-disease-a-systematic-review
#18
Troy Morrison, Sara Jones, Ryan S Causby, Kerry Thoirs
INTRODUCTION: Diabetes mellitus (DM) is associated with hyperglycaemia and advanced glycosylation end-products. In the foot, the consequences of chronic or uncontrolled diabetes are micro and macrovascular disease, neuropathy, reduced joint mobility and structural and soft tissue changes that increase the risk of ulcer development and amputation. Diabetes foot assessment currently includes a comprehensive history, neurological and vascular assessments and examination focussed on dermatological and musculoskeletal abnormalities...
2018: PloS One
https://www.readbyqxmd.com/read/29904416/experimental-study-of-epidermal-growth-factor-and-acidic-fibroblast-growth-factor-in-the-treatment-of-diabetic-foot-wounds
#19
Jiasheng Xu, Dinghong Min, Guanghua Guo, Xincheng Liao, Zhonghua Fu
The aim of the present study was to investigate the effect of epidermal growth factor (EGF) and acidic fibroblast growth factor (aFGF) on the healing of diabetic foot wounds. A total of 199 patients with diabetic foot ulcers were recruited and randomly divided into four groups: A recombinant human EGF group (n=50), an aFGF group (n=50), a combined EGF and aFGF group (n=50) and a normal saline control group (n=49). Patients in all groups received a daily dressing change and growth factor reagents were applied topically when dressing...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29904239/kinetic-studies-of-complex-biomedical-process-by-magnetic-resonance-cuban-experiences
#20
Carlos Cabal Mirabal, Adolfo Fernández García, Manuel Lores Guevara, Evelio González, Leonardo Oramas Díaz
The potentials of the magnetic resonance (MR) methods in the research of biomedical systems have been demonstrated during the 70 years of its existence. It is presented that the Cuban experience in quantitative magnetic resonance associated with molecular, preclinical and clinical studies of significant diseases and drugs development. MR "in vitro" and "in vivo" studies of sickle cell disease, the diabetic foot ulcer, the brain tumor response and the magnetic nano-particle pharmacokinetics, are presented as example...
2018: Applied Magnetic Resonance
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