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https://www.readbyqxmd.com/read/29683538/effectiveness-of-viable-cryopreserved-placental-membranes-for-management-of-diabetic-foot-ulcers-in-a-real-world-setting
#1
Katherine M Raspovic, Dane K Wukich, Daniel Q Naiman, Lawrence A Lavery, Robert S Kirsner, Paul J Kim, John S Steinberg, Christopher E Attinger, Alla Danilkovitch
In a multicenter randomized controlled trial (RCT), the use of viable cryopreserved placental membrane (vCPM) for chronic diabetic foot ulcers (DFUs) resulted in a higher proportion of wound closure in comparison to good wound care: 62% vs. 21% (p < 0.01). However, patients in RCTs are not representative of daily physician practice. Healthcare databases serve as a valuable tool to evaluate therapy effectiveness and to supplement evidence from RCTs. The objective of this study was to evaluate the effectiveness of vCPM for DFU management using Net Health's WoundExpert® electronic health records (EHR)...
April 23, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29683361/human-recombinant-epidermal-growth-factor-in-skin-lesions-77-cases-in-epitelizando-project
#2
Jordi Esquirol-Caussa, Elisabeth Herrero-Vila
OBJECTIVE: To analyze compounded recombinant human Epidermal Growth Factor (rhEGF) effectiveness on skin lesions through a case series. DESIGN: Multicentric series of skin lesions treated with topical recombinant human Epidermal Growth Factor. SITE: Patients from 56 different health professionals, three different countries, two recruitment years. PARTICIPANTS: 77 patients with skin lesions, mean age 63.15 years (min = 18, max = 95); 53...
April 23, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29682995/efficacy-and-safety-of-the-combination-of-isosorbide-dinitrate-spray-and-chitosan-gel-for-the-treatment-of-diabetic-foot-ulcers-a-double-blind-randomized-clinical-trial
#3
Sylvia Elena Totsuka Sutto, Yunuen Itzet Rodríguez Roldan, Ernesto German Cardona Muñoz, Teresa Arcelia Garcia Cobian, Sara Pascoe Gonzalez, Abril Martínez Rizo, Miriam Mendez Del Villar, Leonel García Benavides
AIM: To evaluate whether a combination of isosorbide dinitrate spray and chitosan gel (10%) topically applied can have additive benefits for management of diabetic foot ulcers. METHODS: In a randomized, placebo-controlled, double-blinded clinical trial, 68 patients were divided into four groups: Group 1: treated with chitosan gel; Group 2: isosorbide dinitrate spray; Group 3: combination of isosorbide dinitrate spray and chitosan gel; Group 4: placebo. RESULTS: Histological analyses showed a significant regeneration in all groups ( p < 0...
April 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29682897/an-aseptically-processed-acellular-reticular-allogenic-human-dermis-improves-healing-in-diabetic-foot-ulcers-a-prospective-randomised-controlled-multicentre-follow-up-trial
#4
Charles M Zelen, Dennis P Orgill, Thomas E Serena, Robert E Galiano, Marissa J Carter, Lawrence A DiDomenico, Jennifer Keller, Jarrod P Kaufman, William W Li
Aseptically processed human reticular acellular dermal matrix (HR-ADM) has been previously shown to improve wound closure in 40 diabetic patients with non-healing foot ulcers. The study was extended to 40 additional patients (80 in total) to validate and extend the original findings. The entire cohort of 80 patients underwent appropriate offloading and standard of care (SOC) during a 2-week screening period and, after meeting eligibility criteria, were randomised to receive weekly applications of HR-ADM plus SOC or SOC alone for up to 12 weeks...
April 22, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29682401/a-factor-increasing-venous-contamination-on-bolus-chase-three-dimensional-magnetic-resonance-imaging-charcot-neuroarthropathy
#5
Mehmet B Çildağ, Mustafa B Ertuğrul, Ömer Fk Köseoğlu, David G Armstrong
Background: The study aimed to evaluate the ratio of venous contamination in diabetic cases without foot lesion, with foot lesion and with Charcot neuroarthropathy (CN). Materials and Methods: Bolus-chase three-dimensional magnetic resonance (MR) of 396 extremities of patients with diabetes mellitus was analyzed, retrospectively. Extremities were divided into three groups as follows: diabetic patients without foot ulcer or Charcot arthropathy (Group A), patients with diabetic foot ulcers (Group B) and patients with CN accompanying diabetic foot ulcers (Group C)...
2018: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/29679687/a-novel-technique-indocyanine-green-angiography-to-prognosticate-healing-of-foot-ulcer-in-critical-limb-ischemia
#6
Hiten M Patel, Shahzad S Bulsara, Shubhabrata Banerjee, Tapish Sahu, Virender K Sheorain, Tarun Grover, Rajiv Parakh
BACKGROUND: To predict wound healing in patients with critical limb ischemia(CLI) is ongoing issue. Currents methods like ankle-brachial index (ABI), color doppler and transcutaneous oxygen pressure (TCPO2 ), CT angiography are lacking in demonstrating regional perfusion. Indocyanine green angiography (ICGA) has the potential to provide regional perfusion information lacking in other methods. To demonstrate successes of revascularization procedure in CLI patients based on ICGA data this study was conducted...
April 18, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29678354/actin-dynamics-at-focal-adhesions-a-common-endpoint-and-putative-therapeutic-target-for-proteinuric-kidney-diseases
#7
REVIEW
Sanja Sever, Mario Schiffer
Proteinuria encompasses diverse causes including both genetic diseases and acquired forms such as diabetic and hypertensive nephropathy. The basis of proteinuria is a disturbance in size selectivity of the glomerular filtration barrier, which largely depends on the podocyte: a terminally differentiated epithelial cell type covering the outer surface of the glomerulus. Compromised podocyte structure is one of the earliest signs of glomerular injury. The phenotype of diverse animal models and podocyte cell culture firmly established the essential role of the actin cytoskeleton in maintaining functional podocyte structure...
April 17, 2018: Kidney International
https://www.readbyqxmd.com/read/29675434/the-role-of-serum-procalcitonin-interleukin-6-and-fibrinogen-levels-in-differential-diagnosis-of-diabetic-foot-ulcer-infection
#8
Pınar Korkmaz, Havva Koçak, Kevser Onbaşı, Polat Biçici, Ahmet Özmen, Cemile Uyar, Duru Mıstanoğlu Özatağ
Aims: We aimed to evaluate the roles of interleukin-6 (IL-6), PCT, and fibrinogen levels in the differential diagnosis of the patients with infected diabetic foot ulcer (IDFU) and noninfected diabetic foot ulcer (NIDFU) and to compare those with C-reactive protein (CRP), white blood cell (WBC), and erythrocyte sedimentation rate (ESR). Methods: Patients over 18 years with a diagnosis of type 2 diabetes mellitus and DFU who were followed up in our hospital between 1 January 2016 and 1 January 2017 were included in the study...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29672623/impaired-vibrotactile-sense-in-children-and-adolescents-with-type-1-diabetes-signs-of-peripheral-neuropathy
#9
Erik Ising, Lars B Dahlin, Helena Elding Larsson
OBJECTIVE: To investigate whether multi-frequency vibrometry can identify individuals with elevated vibration perception thresholds (VPTs), reflecting impaired vibrotactile sense, among children and adolescents with type 1 diabetes. METHODS: In 72 pediatric patients with type 1 diabetes, VPTs were evaluated for seven frequencies on two sites of the hand, and five frequencies on two sites of the foot. Z-scores, based on previously collected reference data, were calculated...
2018: PloS One
https://www.readbyqxmd.com/read/29666111/decreasing-an-offloading-device-s-size-and-offsetting-its-imposed-limb-length-discrepancy-lead-to-improved-comfort-and-gait
#10
Ryan T Crews, Joseph Candela
OBJECTIVE: Patient adherence is a challenge in offloading diabetic foot ulcers (DFUs) with removable cast walkers (RCWs). The size and weight of an RCW, changes to gait, and imposed limb length discrepancies may all discourage adherence. This study sought to determine whether RCW size and provision of a contralateral limb lift affected users' comfort and gait. RESEARCH DESIGN AND METHODS: Twenty-five individuals at risk for DFUs completed several 20-m walking trials under five footwear conditions: bilateral standardized shoes, a knee-high RCW with shoe with or without an external shoe lift contralaterally, and an ankle-high RCW with shoe with or without an external shoe lift contralaterally...
April 17, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29661917/association-of-hemoglobin-a-1c-and-wound-healing-in-diabetic-foot-ulcers
#11
Betiel K Fesseha, Christopher J Abularrage, Kathryn F Hines, Ronald Sherman, Priscilla Frost, Susan Langan, Joseph Canner, Kendall C Likes, Sayed M Hosseini, Gwendolyne Jack, Caitlin W Hicks, Swaytha Yalamanchi, Nestoras Mathioudakis
OBJECTIVE: This study evaluated the association between hemoglobin A1c (A1C) and wound outcomes in patients with diabetic foot ulcers (DFUs). RESEARCH DESIGN AND METHODS: We conducted a retrospective analysis of an ongoing prospective, clinic-based study of patients with DFUs treated at an academic institution during a 4.7-year period. Data from 270 participants and 584 wounds were included in the analysis. Cox proportional hazards regression was used to assess the incidence of wound healing at any follow-up time in relation to categories of baseline A1C and the incidence of long-term (≥90 days) wound healing in relation to tertiles of nadir A1C change and mean A1C change from baseline, adjusted for potential confounders...
April 16, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29651391/the-wound-healing-effects-of-herbal-cream-containing-oliveria-decumbens-and-pelargonium-graveolens-essential-oils-in-diabetic-foot-ulcer-model
#12
Mohaddese Mahboubi, Mohsen Taghizadeh, Tahereh Khamechian, Omid Reza Tamtaji, Rasoul Mokhtari, Sayyed Alireza Talaei
BACKGROUND: The number of diabetic patients in adult population is increasing. All this population are at risk of developing diabetic foot ulcers (DFUs) that are associated with unwanted ailments and high mortality. In spite of current therapies for DFUs, further therapies are needed to help the patients. METHODS: The efficacy of herbal cream containing Pelargonium graveolens and Oliveria decombens essential oils was evaluated topically for treatment of DFUs in rat animal model in comparison with two other herbal formulas containing each essential oil alone, placebo (the basic formula without active ingredients) and normal saline as control groups...
January 2018: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29651304/managing-diabetic-foot-infections-a-survey-of-australasian-infectious-diseases-clinicians
#13
Robert J Commons, Edward Raby, Eugene Athan, Hasan Bhally, Sharon Chen, Stephen Guy, Paul R Ingram, Katy Lai, Chris Lemoh, Lyn-Li Lim, Laurens Manning, Spiros Miyakis, Mary O'Reilly, Adam Roberts, Marjoree Sehu, Adrienne Torda, Mauro Vicaretti, Peter A Lazzarini
Background: Diabetic foot infections (DFI) present a major morbidity, mortality and economic challenge for the tertiary health sector. However, lack of high quality evidence for specific treatment regimens for patients with DFIs may result in inconsistent management. This study aimed to identify DFI caseload proportion and patterns of clinical practice of Infectious Diseases (ID) Physicians and Trainees within Australia and New Zealand. Methods: A cross-sectional online survey of Australian and New Zealand ID Physicians and Trainees was undertaken, to estimate the overall ID caseload devoted to patients with DFIs and assess clinicians' management practices of patients with DFIs...
2018: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/29651102/exosomes-from-adipose-derived-stem-cells-overexpressing-nrf2-accelerate-cutaneous-wound-healing-by-promoting-vascularization-in-a-diabetic-foot-ulcer-rat-model
#14
Xue Li, Xiaoyun Xie, Weishuai Lian, Rongfeng Shi, Shilong Han, Haijun Zhang, Ligong Lu, Maoquan Li
Diabetic foot ulcers (DFU) increase the risks of infection and amputation in patients with diabetes mellitus (DM). The impaired function and senescence of endothelial progenitor cells (EPCs) and high glucose-induced ROS likely exacerbate DFUs. We assessed EPCs in 60 patients with DM in a hospital or primary care setting. We also evaluated the therapeutic effects of exosomes secreted from adipose-derived stem cells (ADSCs) on stress-mediated senescence of EPCs induced by high glucose. Additionally, the effects of exosomes and Nrf2 overexpression in ADSCs were investigated in vitro and in vivo in a diabetic rat model...
April 13, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29650101/foot-care
#15
John M Embil, Zaina Albalawi, Keith Bowering, Elly Trepman
No abstract text is available yet for this article.
April 2018: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29649067/outpatient-negative-pressure-wound-therapy-following-surgical-debridement-results-and-complications
#16
Eran Tamir, Aharon S Finestone, Itay Wiser, Yoram Anekstein, Gabriel Agar
OBJECTIVE: To present results and complications in a case series of outpatients with diabetic and neuropathic foot ulcers with exposed bone following surgical debridement treated with negative-pressure wound therapy (NPWT). METHODS: Retrospective data were obtained from digital medical records from the Maccabi Health Services High Risk Foot Clinic in Tel Aviv, Israel, between 2009 and 2014. Medical records examined were those of clinic outpatients with exposed bone following partial foot amputation or selective bone debridement (University of Texas grade III-A) treated with NPWT...
April 11, 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29644884/prospective-analysis-of-surgical-bone-margins-after-partial-foot-amputation-in-diabetic-patients-admitted-with-moderate-to-severe-foot-infections
#17
Brian M Schmidt, Jonathan B McHugh, Rajiv M Patel, James S Wrobel
BACKGROUND: Osteomyelitis is common in diabetic foot infections and medical management can lead to poor outcomes. Surgical management involves sending histopathologic and microbiologic specimens which guides future intervention. We examined the effect of obtainment of surgical margins in patients undergoing forefoot amputations to identify patient characteristics associated with outcomes. Secondary aims included evaluating interobserver reliability of histopathologic data at both the distal-to and proximal-to surgical bone margin...
April 1, 2018: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/29644145/publicly-reported-wound-healing-rates-the-fantasy-and-the-reality
#18
REVIEW
Caroline E Fife, Kristen A Eckert, Marissa J Carter
Significance: We compare real-world data from the U.S. Wound Registry (USWR) with randomized controlled trials and publicly reported wound outcomes and develop criteria for honest reporting of wound outcomes, a requirement of the new Quality Payment Program (QPP). Recent Advances: Because no method has existed by which wounds could be stratified according to their likelihood of healing among real-world patients, practitioners have reported fantastically high healing rates. The USWR has developed several risk-stratified wound healing quality measures for diabetic foot ulcers (DFUs) and venous leg ulcers (VLUs) as part of its Qualified Clinical Data Registry (QCDR)...
March 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29626020/bone-and-joint-infection
#19
Julia Colston, Bridget Atkins
Bone and joint infections include septic arthritis, prosthetic joint infections, osteomyelitis, spinal infections (discitis, vertebral osteomyelitis and epidural abscess) and diabetic foot osteomyelitis. All of these may present through the acute medical take. This article discusses the pathogenesis of infection and highlights the importance of taking a careful history and fully examining the patient. It also emphasises the importance of early surgical intervention in many cases. Consideration of alternative diagnoses, appropriate imaging and high-quality microbiological sampling is important to allow appropriate and targeted antimicrobial therapy...
March 2018: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/29622357/the-society-for-vascular-surgery-wound-ischemia-and-foot-infection-wifi-classification-independently-predicts-wound-healing-in-diabetic-foot-ulcers
#20
Caitlin W Hicks, Joseph K Canner, Nestoras Mathioudakis, Ronald Sherman, Mahmoud B Malas, James H Black, Christopher J Abularrage
OBJECTIVE: Previous studies have reported correlation between the Wound, Ischemia, and foot Infection (WIfI) classification system and wound healing time on unadjusted analyses. However, in the only multivariable analysis to date, WIfI stage was not predictive of wound healing. Our aim was to examine the association between WIfI classification and wound healing after risk adjustment in patients with diabetic foot ulcers (DFUs) treated in a multidisciplinary setting. METHODS: All patients presenting to our multidisciplinary DFU clinic from June 2012 to July 2017 were enrolled in a prospective database...
April 2, 2018: Journal of Vascular Surgery
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