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https://www.readbyqxmd.com/read/28829074/recent-advances-in-biomaterials-for-the-treatment-of-diabetic-foot-ulcers
#1
REVIEW
Lisa N Kasiewicz, Kathryn A Whitehead
Diabetes mellitus is one of the most challenging epidemics facing the world today, with over 300 million patients affected worldwide. A significant complication associated with diabetes is hyperglycemia, which impairs wound healing. The rise in the diabetic patient population in recent years has precipitated an increase in the incidence and prevalence of chronic diabetic wounds, most commonly the diabetic foot ulcer. Although foot ulcers are difficult to treat due to their complicated pathology, outcomes have improved with the development of increasingly sophisticated biomaterials that accelerate healing...
August 22, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28827604/sarcopenia-is-independently-associated-with-diabetic-foot-disease
#2
Qingfeng Cheng, Jinbo Hu, Ping Yang, Xueting Cao, Xuefeng Deng, Qin Yang, Zhiping Liu, Shumin Yang, Richa Goswami, Yue Wang, Ting Luo, Kun Liao, Qifu Li
The aim of this study was to investigate the association of sarcopenia and diabetic foot disease (DFD) in a cross-sectional study. Body composition was assessed using dual-energy X-ray-absorptiometry (DXA) among 1105 patients with type 2 diabetes (120 patients with newly diagnosed DFD [DFD duration less than 3 months]). Severity of DFD was assessed, referring to foot ulcers, Wagner grade and the percentage of amputation. Skeletal muscle index (SMI) was calculated, and sarcopenia was defined as SMI less than 7...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28827076/metformin-and-ascorbic-acid-combination-therapy-ameliorates-type-2-diabetes-mellitus-and-comorbid-depression-in-rats
#3
Naveen Shivavedi, Mukesh Kumar, Gullanki Naga Venkata Charan Tej, Prasanta Kumar Nayak
Diabetes mellitus and depression are the common comorbid disorders affecting humans worldwide. There is an unmet need to develop therapeutic strategies to treat both diabetes mellitus and comorbid depression. The present study evaluated the effectiveness of metformin and ascorbic acid against type 2 diabetes mellitus and comorbid depression in rats. Four groups of diabetic rats were orally administered with vehicle (1 mL/kg), metformin (25 mg/kg), ascorbic acid (25 mg/kg), or combination of metformin (25 mg/kg) and ascorbic acid (25 mg/kg) for 11 consecutive days...
August 18, 2017: Brain Research
https://www.readbyqxmd.com/read/28826262/topical-propolis-improves-wound-healing-in-patients-with-diabetic-foot-ulcer-a-randomized-controlled-trial
#4
Mozhgan Afkhamizadeh, Robab Aboutorabi, Hassan Ravari, Mohsen Fathi Najafi, Sajad Ataei Azimi, Adineh Javadian Langaroodi, Mohammad Ali Yaghoubi, Amirhossein Sahebkar
In this randomized controlled trial, diabetic patients with foot ulcers (Wagner grades 1 and 2) were randomly assigned to conventional therapies for diabetic foot ulcer plus topical propolis ointment (5%; twice daily) or conventional therapies alone. The process of ulcer healing was observed during 4 weeks and compared between the two groups regarding the size, erythema, exudates, white blood cell (WBC) count and erythrocyte sedimentation rate (ESR). The process of ulcer size reduction during the four-week period of study was significantly different between the groups...
August 22, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28817962/patients-with-diabetic-foot-disease-fear-major-lower-extremity-amputation-more-than-death
#5
Dane K Wukich, Katherine M Raspovic, Natalie C Suder
BACKGROUND: The aim of this study was to identify the most-feared complications of diabetes mellitus (DM), comparing those with diabetic foot pathology with those without diabetic foot pathology. METHODS: We determined the frequency of patients ranking major lower-extremity amputation (LEA) as their greatest fear in comparison to blindness, death, diabetic foot infection (DFI), or end-stage renal disease (ESRD) requiring dialysis. We further categorized the study group patients (N = 207) by their pathology such as diabetic foot ulcer (DFU), Charcot neuroarthropathy, foot infection, or acute neuropathic fractures and dislocations...
February 1, 2017: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/28817237/dysregulation-of-wound-healing-mechanisms-in-diabetes-and-the-importance-of-negative-pressure-wound-therapy-npwt
#6
Mogher Khamaisi, Sarit Balanson
Diabetes is a serious disease with severe side effects and comorbidities. Diabetic foot with its chronic non-healing ulcers, or diabetic food ulcers (DFU) as they are commonly called, can be devastating, even leading to amputation. Many therapies exist to assist and improve wound healing. One exciting discovery is the use of negative pressure wound therapy (NPWT) as an adjunct to standard treatment. Few studies have substantively explored the molecular mechanisms of NPWT and why we see improved wound healing, a concept that demands more research...
August 17, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28816217/multispecialty-consensus-statement-for-primary-care-management-of-diabetic-foot-disease-in-india
#7
Arun Bal, Charudatta Chaudhari, Vijay Langer, Dipak Vyas, G Thulasikumar, Milind Ruke, Madhuri A Gore, Pinjala Ramakrishna, Rakesh K Khazanchi, S R Subrammaniyan, S Raja Sabapathy, Sanjay Desai, Sanjay Vaidya, Srikanth Vijayasimha, Sudhir Jain, Sunil Chaudhary, Sunil Kari, Tushar Rege
No abstract text is available yet for this article.
March 2017: National Medical Journal of India
https://www.readbyqxmd.com/read/28814244/history-prevalence-and-assessment-of-limited-joint-mobility-from-stiff-hand-syndrome-to-diabetic-foot-ulcer-prevention
#8
Piergiorgio Francia, Roberto Anichini, Giuseppe Seghieri, Alessandra De Bellis, Massimo Gulisano
INTRODUCTION: Diabetes mellitus (DM) is one of the most important global public health problems. Patients with DM may develop different dreaded complications during their lifetime, one of which is limited joint mobility (LJM). Joint abnormalities and LJM are problems that can arise at disease onset, and progressively worsen together with the disease. Because LJM shares causal factors with other chronic diabetes-induced complications, its study has been considered useful for monitoring the risk of developing other chronic complications due to DM such as vascular disease or diabetic foot...
August 16, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28805783/-effect-of-the-cytoflavin-on-the-distal-polyneuropathy-severity-in-patients-with-diabetic-foot-syndrome-with-arteries-mediacalcinosis
#9
V D Skripko, A L Kovalenko, V A Zaplutanov
The aim of the study was to evaluate the effectiveness of cytoflavin in the complex treatment of patients with diabetic foot syndrome. MATERIAL AND METHODS: The research is based on the results of a comprehensive survey of 140 people with diabetic foot syndrome. Depending on the treatment, all patients were divided into 2 groups. The first group (n=35) received basic therapy. The second group (n=35) in addition to basic therapy received cytoflavin 10 ml (+200 ml 0.9% NaCl) for 10 days, followed by switching to the tablet form of the drug 2 tablets twice a day for 1 month...
2017: Khirurgiia
https://www.readbyqxmd.com/read/28804593/an-innovative-sealed-shoe-to-off-load-and-heal-diabetic-forefoot-ulcers-a-feasibility-study
#10
Gustav Jarl, Roy Tranberg
Background: Non-removable knee-high devices are the gold standard to treat diabetic foot ulcers located on the plantar forefoot, but they immobilize the ankle, which restricts daily life activities and has negative effects on joint functioning. Objective: To investigate the feasibility of sealing a therapeutic shoe to off-load and heal diabetic forefoot ulcers. Design: A case series of seven men with type 2 diabetes and a metatarsal head ulcer were prescribed therapeutic shoes and custom-made insoles. The shoe was sealed with a plastic band...
2017: Diabetic Foot & Ankle
https://www.readbyqxmd.com/read/28804592/diabetic-foot-disease-in-oman-a-call-for-%C3%A2-more-research
#11
Ibrahim Saleh Al-Busaidi
No abstract text is available yet for this article.
July 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/28802698/in-hospital-costs-of-diabetic-foot-disease-treated-by-a-multidisciplinary-foot-team
#12
Willem D Rinkel, Jacky Luiten, Jelle van Dongen, Bram Kuppens, Johan W Van Neck, Suzanne Polinder, Manuel Castro Cabezas, J Henk Coert
BACKGROUND: The diabetic foot imposes significant burden on healthcare systems. Obtaining knowledge on the extent of the costs of diabetic foot ulcers (DFUs) is of value to health care researchers investigating cost-effectiveness of interventions that prevent these costly complications. OBJECTIVES: To estimate the in-hospital costs associated with the treatment of DFUs by a multidisciplinary diabetic foot team. METHODS: Persons with DFUs presenting to our team in 2013 and 2014 were followed and use of care was estimated...
July 29, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28802220/comparison-of-lower-limb-muscle-strength-between-diabetic-neuropathic-and-healthy-subjects-using-opensim
#13
Alessandra Scarton, Ilse Jonkers, Annamaria Guiotto, Fabiola Spolaor, Gabriella Guarneri, Angelo Avogaro, Claudio Cobelli, Zimi Sawacha
Diabetes neuropathy and vasculopathy are the two major complications of diabetes mellitus, leading to diabetic foot disease, of which the worst consequences are plantar ulcers and amputations. Motor impairments like joint stiffness and loss of balance are distinctive effects of diabetes and they have been extensively explored. However, while altered muscle function has been also assessed through experimentally measured surface electromyography, little is known about muscle forces. The objective of this study was to estimate muscle forces in subjects with diabetes and to use these data to identify differences with respect to a population of healthy subjects matched for age and BMI...
July 31, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28802182/inflammatory-markers-as-risk-factors-for-infection-with-multidrug-resistant-microbes-in-diabetic-foot-subjects
#14
Saba Noor, Abhijit Girish Borse, Maaz Ozair, Alok Raghav, Iqbal Parwez, Jamal Ahmad
BACKGROUND: Diabetic foot ulcers (DFUs), a dreadful microvascular complication of diabetes is responsible for substantial increase in morbidity and mortality. Infection, not a cause, but a consequence in DFUs that accounts for minor or major limb loss. The current study aimed to evaluate the microbial etiology of infected diabetic foot ulcers in northern tertiary care hospital, assessment of risk factors and role of inflammatory markers involved in colonization of multidrug-resistant organisms (MDROs) and their impact on the outcome...
May 3, 2017: Foot
https://www.readbyqxmd.com/read/28800712/outcomes-achieved-with-use-of-a-prefabricated-roll-on-total-contact-cast
#15
Jonathan F Arnold, Valerie Marmolejo
BACKGROUND: The total contact cast (TCC) is considered the gold standard for offloading of plantar diabetic foot ulcerations, yet its use remains suboptimal for a variety of reasons. Prefabricated TCC systems have been developed to help enhance TCC use. The primary objective of this study was to determine if healing rates obtained with use of a prefabricated roll-on TCC were similar to those reported with conventional TCC use. Secondary outcomes measured were the incidence of iatrogenic ulceration, amputation, and recurrent ulceration, and patient tolerance of the device...
August 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28797280/illness-perception-diabetes-knowledge-and-self-care-practices-among-type-2-diabetes-patients-a-cross-sectional-study
#16
Nuworza Kugbey, Kwaku Oppong Asante, Korkor Adulai
BACKGROUND: Self-care practices among persons living with type-2 diabetes are very crucial in diabetes manages as poor self-care results in complications. However, little research exists within the Ghanaian context. This study examined whether type-2 diabetes patients' illness perception and diabetes knowledge significantly predict diabetes self-care practices. METHODS: A cross-sectional survey design was employed and a total of 160 participants (45 males and 115 females) were sampled from a general hospital in Accra...
August 10, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28793377/are-characteristics-of-team-members-important-for-quality-management-of-chronic-patients-at-primary-care-level
#17
Zalika Klemenc-Ketis, Antonija Poplas-Susič
AIMS AND OBJECTIVES: We wanted to determine the possible associations between higher levels of selected quality indicators and the characteristics of providers. BACKGROUND: In 2011, an ongoing project on a new model of family medicine practice was launched in Slovenia; the a family physicians' working team (a family physician and a practice nurse), was extended by a nurse practitioner working 0.5 full-time equivalents. This was an example of a personalised team approach to managing chronic patients...
August 9, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28791310/prevalence-of-diabetic-foot-ulcer-and-associated-factors-among-adult-diabetic-patients-who-attend-the-diabetic-follow-up-clinic-at-the-university-of-gondar-referral-hospital-north-west-ethiopia-2016-institutional-based-cross-sectional-study
#18
Tesfamichael G Mariam, Abebaw Alemayehu, Eleni Tesfaye, Worku Mequannt, Kiber Temesgen, Fisseha Yetwale, Miteku Andualem Limenih
Diabetes mellitus is a metabolic disorder which is characterized by multiple long-term complications that affect almost every system in the body. Foot ulcers are one of the main complications of diabetes mellitus. However, there is limited evidence on the occurrence of foot ulcer and influencing factors in Ethiopia. An institutional-based cross-sectional study was conducted in Gondar University Hospital, Ethiopia, to investigate foot ulcer occurrence in diabetic patients. Systematic random sampling was used to select 279 study participants...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28789834/diabetes-complications-in-sudanese-individuals-with-type-2-diabetes-overlooked-problems-in-sub-saharan-africa
#19
Heitham Awadalla, Sufian K Noor, Wadie M Elmadhoun, Ahmed O Almobarak, Nehad E Elmak, Sulaf I Abdelaziz, Amel A Sulaiman, Mohamed H Ahmed
BACKGROUND: Diabetes mellitus (DM) is a major health problem in Sudan and is a leading cause of morbidity and mortality. The objective of this study is to determine the prevalence of complications of type 2 diabetes across different cities in the country. METHODS: Individuals with type 2 diabetes, who have been on treatment for DM for at least one year and volunteered to participate, were selected from two diabetes centers in Sudan (Khartoum and Atbara). Participants were interviewed using standardized pretested questionnaire to record medical history, socio-demographic, life style characteristics and presence of complications of diabetes...
July 29, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28783067/a-study-of-thermistor-performance-within-a-textile-structure
#20
Theodore Hughes-Riley, Pasindu Lugoda, Tilak Dias, Christophe L Trabi, Robert H Morris
Textiles provide an ideal structure for embedding sensors for medical devices. Skin temperature measurement is one area in which a sensor textile could be particularly beneficial; pathological skin is normally very sensitive, making the comfort of anything placed on that skin paramount. Skin temperature is an important parameter to measure for a number of medical applications, including for the early detection of diabetic foot ulcer formation. To this end an electronic temperature-sensor yarn was developed by embedding a commercially available thermistor chip into the fibres of a yarn, which can be used to produce a textile or a garment...
August 5, 2017: Sensors
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