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https://www.readbyqxmd.com/read/28346963/point-of-care-testing-in-neurosurgery
#1
Christopher Beynon, Lars Wessels, Andreas W Unterberg
Coagulation disorders can have a major impact on the outcome of neurosurgical patients. The central nervous system is located within the closed space of the skull, and therefore, intracranial hemorrhage can lead to intracranial hypertension. Acute brain injury has been associated with alterations of various hemostatic parameters. Point-of-care (POC) techniques such as rotational thromboelastometry are able to identify markers of coagulopathy which are not reflected by standard assessment of hemostasis (e.g...
March 27, 2017: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/28346947/health-and-public-policy-to-facilitate-effective-prevention-and-treatment-of-substance-use-disorders-involving-illicit-and-prescription-drugs-an-american-college-of-physicians-position-paper
#2
Ryan Crowley, Neil Kirschner, Andrew S Dunn, Sue S Bornstein
Substance use disorders involving illicit and prescription drugs are a serious public health issue. In the United States, millions of individuals need treatment for substance use disorders but few receive it. The rising number of drug overdose deaths and the changing legal status of marijuana pose new challenges. In this position paper, the American College of Physicians maintains that substance use disorder is a treatable chronic medical condition and offers recommendations on expanding treatment options, the legal status of marijuana, addressing the opioid epidemic, insurance coverage of substance use disorders treatment, education and workforce, and public health interventions...
March 28, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28346121/can-memories-of-traumatic-experiences-or-addiction-be-erased-or-modified-a-critical-review-of-research-on-the-disruption-of-memory-reconsolidation-and-its-applications
#3
Michael Treanor, Lily A Brown, Jesse Rissman, Michelle G Craske
Recent research suggests that the mere act of retrieving a memory can temporarily make that memory vulnerable to disruption. This process of "reconsolidation" will typically restabilize the neural representation of the memory and foster its long-term storage. However, the process of reconsolidating the memory takes time to complete, and during this limited time window, the original memory may be modified either by the presentation of new information or with pharmacological agents. Such findings have prompted rising interest in using disruption during reconsolidation as a clinical intervention for anxiety, posttraumatic stress, and substance use disorders...
March 2017: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/28345966/the-importance-of-standardization-of-stimuli-for-functional-mri-tasks-to-evaluate-substance-use-disorder-pathology
#4
Claire E Wilcox, Eric D Claus
No abstract text is available yet for this article.
March 27, 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28345950/introduction-to-special-issue-on-animal-models-of-neuropsychiatric-disorders-and-substance-use-disorders-progress-and-gaps
#5
Mark A Smith, Suzette M Evans
This is an introduction to the special issue, "Animal Models of Neuropsychiatric Disorders and Substance Use Disorders: Progress and Gaps." This issue presents 6 original research reports describing the use of mice and rats to model neurodevelopmental disorders, depressive disorders, anxiety disorders, and substance use disorders. Collectively, these studies demonstrate the progress of the field and the gaps and challenges that remain. They also illustrate the range of conditions that are informed by animal models and identify the clinical populations that stand to benefit from their use in preclinical research...
April 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28345440/the-economic-burden-of-opioid-abuse-updated-findings
#6
Noam Y Kirson, Lauren M Scarpati, Caroline J Enloe, Aliya P Dincer, Howard G Birnbaum, Tracy J Mayne
BACKGROUND: Opioid pain relievers can be highly effective in providing relief for patients suffering from pain. At the same time, prescription opioid abuse, dependence, overdose, and poisoning (hereinafter "abuse") have become a national public health concern. Opioid abuse is also costly: previous estimates of the annual excess costs of opioid abuse to payers range from approximately $10,000 to $20,000 per patient. OBJECTIVES: To (a) provide a comprehensive, current estimate of the economic burden of opioid abuse to commercial payers and (b) explore the drivers of these excess costs of abuse...
April 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28345210/geographic-disparities-in-availability-of-opioid-use-disorder-treatment-for-medicaid-enrollees
#7
Amanda J Abraham, Christina M Andrews, Marissa E Yingling, Jerry Shannon
OBJECTIVE: To examine county-level geographic variation in treatment admissions among opioid treatment programs (OTPs) that accept Medicaid in the continental United States. DATA SOURCES/STUDY SETTING: Data come from the 2012 National Survey of Substance Abuse Treatment Services. STUDY DESIGN/DATA COLLECTION: We used local measures of spatial autocorrelation (LISA) analysis to identify (1) clusters of counties with higher and lower than average rates of opioid use disorders and (2) clusters of counties with higher and lower than average treatment admissions among OTPs that accept Medicaid, adjusting for county population size...
March 27, 2017: Health Services Research
https://www.readbyqxmd.com/read/28344568/time-is-money-the-decision-making-of-smartphone-high-users-in-gain-and-loss-intertemporal-choice
#8
Zixuan Tang, Huijun Zhang, An Yan, Chen Qu
Nowadays the smartphone plays an important role in our lives. While it brings us convenience and efficiency, its overuse can cause problems. Although a great number of studies have demonstrated that people affected by substance abuse, pathological gambling, and internet addiction disorder have lower self-control than average, scarcely any study has investigated the decision making of smartphone high users by using a behavioral paradigm. The present study employed an intertemporal task, the Smartphone Addiction Inventory (SPAI) and the Barratt Impulsiveness Scale 11th version (BIS-11) to explore the decision control of smartphone high users in a sample of 125 college students...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28343195/research-of-the-protection-actions-of-derived-2-oxoindole-in-acute-stress
#9
Ruslan V Lutsenko, Andrei V Vakhnenko, Elena V Vlasova
INTRODUCTION: Correction of pathological anxiety and stress level of frustration leads to the development of new anxiolytics, notably including derivatives of 2-oksoyndolyn- 3-hlyoksylic acid. The aim of work - to study the effect of 2-oksyindolin-3-hlyoksylic acid on emotional and behavioral reactions of rats subjected to behavioral stress tests of different averiability. MATERIALS AND METHODS: In experiments on 150 white mature male rats Wistar investigated the effects of 2-oksoindolin (2-hydroxy-N-naphthalene-1-yl-2-(2-hydroxy-1,2- dihydro-indole-3-ylidene)-acetamide) with laboratory codes 18 when intraperitoneally administered to acute immobilization stress on Sel'ye on emotional and behavioral responses of animals to test «open field», «a raised cross maze» and test «conflict behavior» (option Vogel)...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28343067/reading-problems-and-major-mental-disorders-co-occurrences-and-familial-overlaps-in-a-swedish-nationwide-cohort
#10
Martin Cederlöf, Barbara Maughan, Henrik Larsson, Brian M D'Onofrio, Robert Plomin
Reading problems often co-occur with ADHD and conduct disorder. However, the patterns of co-occurrence and familial overlap between reading problems and other psychiatric disorders have not been systematically explored. We conducted a register-based cohort study including 8719 individuals with reading problems and their siblings, along with matched comparison individuals. Conditional logistic regressions estimated risks for ADHD, autism, obsessive-compulsive disorder, anorexia nervosa, schizophrenia, bipolar disorder, depression, substance use disorder, and violent/non-violent criminality in individuals with reading problems and their siblings...
March 21, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28342535/-professional-stressors-and-common-mental-health-disorders-causal-links
#11
C Nicolas, N Chawky, C Jourdan-Ionescu, M-S Drouin, C Page, N Houlfort, G Beauchamp, M Séguin
According to the World Health Organization, depression has become the leading cause of disability in the world, contributing significantly to the burden of health issues especially in the industrialized countries. This is a major public health problem, with potential impact on work climates, productivity at work and the continued existence of the organizations. Some recent studies have examined potential links between professional factors and common mental health disorders, but none have demonstrated a direct causal link...
March 22, 2017: L'Encéphale
https://www.readbyqxmd.com/read/28341617/internet-delivered-health-interventions-that-work-systematic-review-of-meta-analyses-and-evaluation-of-website-availability
#12
Mary Am Rogers, Kelsey Lemmen, Rachel Kramer, Jason Mann, Vineet Chopra
BACKGROUND: Due to easy access and low cost, Internet-delivered therapies offer an attractive alternative to improving health. Although numerous websites contain health-related information, finding evidence-based programs (as demonstrated through randomized controlled trials, RCTs) can be challenging. We sought to bridge the divide between the knowledge gained from RCTs and communication of the results by conducting a global systematic review and analyzing the availability of evidence-based Internet health programs...
March 24, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28341060/dose-dependent-treatment-with-isotretinoin-induces-more-changes-in-the-ileum-than-in-the-duodenum-and-jejunum-in-wistar-rats
#13
B F Thomazini, M A H Dolder
Acne is the most common skin disorder and can directly affect the patients' self-esteem. Systemic treatment has been indicated for nodular, cystic or persistent acne rather than another type of treatment, such as a topic one. Isotretinoin is an analogue of vitamin A and by suppressing the sebaceous glands the disease can be controlled. This study was designed to mimic the treatment performed in young patients using the dosage of 1mg/kg, and a higher one of 10mg/kg, for 60days in young male Wistar rats. 24 Wistar rats were divided into four groups: control(water), D0(soybean oil, control group), D1(1mg/kg of Isotretinoin solution), D10(10mg/kg of Isotretinoin solution)...
March 9, 2017: Tissue & Cell
https://www.readbyqxmd.com/read/28340903/erratum-to-heterogeneity-in-pathways-to-abstinence-among-women-in-treatment-for-alcohol-use-disorder-journal-of-substance-abuse-treatment-75-2017-1-9
#14
Cathryn Glanton Holzhauer, Elizabeth E Epstein, Amy M Cohn, Barbara S McCrady, Fiona S Graff, Sharon Cook
No abstract text is available yet for this article.
May 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28340233/increase-in-drug-overdose-deaths-involving-fentanyl-rhode-island-january-2012-march-2014
#15
Melissa C Mercado, Steven A Sumner, M Bridget Spelke, Michele K Bohm, David E Sugerman, Christina Stanley
Objective.:  This study identified sociodemographic, substance use, and multiple opioid prescriber and dispenser risk factors among drug overdose decedents in Rhode Island, in response to an increase in overdose deaths (ODs) involving fentanyl. Methods.:  This cross-sectional investigation comprised all ODs reviewed by Rhode Island's Office of the State Medical Examiners (OSME) during January 2012 to March 2014. Data for 536 decedents were abstracted from OSME's charts, death certificates, toxicology reports, and Prescription Monitoring Program (PMP) databases...
March 6, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28339890/pennsylvania-state-core-competencies-for-education-on-opioids-and-addiction
#16
Michael A Ashburn, Rachel L Levine
Objective.:  The objective of this project was to develop core competencies for education on opioids and addiction to be used in all Pennsylvania medical schools. Methods.:  The Pennsylvania Physician General created a task force that was responsible for the creation of the core competencies. A literature review was completed, and a survey of graduating medical students was conducted. The task force then developed, reviewed, and approved the core competencies...
March 2, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28339702/subclinical-chronic-left-ventricular-systolic-dysfunction-resulting-from-phosphine-poisoning
#17
E Szymczyk, M Wiszniewska, J Walusiak-Skorupa, J D Kasprzak, P Lipiec
We present a case of a 32-year-old male crew member of a cargo ship, accidentally exposed to phosphine, a fumigating substance. He and other crew members developed increasing fatigue and digestive disorders 24 h later; two died from acute pulmonary oedema. The patient was admitted to hospital, where bilateral pneumonia, acute nephritis, hepatopathy, electrolyte imbalance and leucopenia were diagnosed. He was discharged from hospital 3 weeks later. He was examined 4 months later for possible chronic consequences of acute phosphine poisoning, which included echocardiography showing normal heart size and cardiac function...
February 21, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/28338724/sex-differences-in-the-development-of-emotion-circuitry-in-adolescents-at-risk-for-substance-abuse-a-longitudinal-fmri-study
#18
Jillian E Hardee, Lora M Cope, Emily C Munier, Robert C Welsh, Robert A Zucker, Mary M Heitzeg
There is substantial evidence for behavioral sex differences in risk trajectories for alcohol and substance use disorders (SUDs), with internalizing factors such as negative affectivity contributing more to female risk. Because the neural development of emotion circuitry varies between males and females across adolescence, it represents a potential mechanism by which underlying neurobiology contributes to SUD risk. Longitudinal functional magnetic resonance imaging (fMRI) was conducted in males and females (n = 18 each) with a family history of alcohol use disorders starting at ages 8-13yrs...
February 21, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28337225/bufei-huoxue-capsule-attenuates-pm2-5-induced-pulmonary-inflammation-in-mice
#19
Yue Jing, Hongchun Zhang, Zhe Cai, Yukun Zhao, Ye Wu, Xuan Zheng, Ying Liu, Yuying Qin, Mingjie Gu, Jin Jin
Atmospheric fine particulate matter 2.5 (PM 2.5) may carry many toxic substances on its surface and this may pose a public health threat. Epidemiological research indicates that cumulative ambient PM2.5 is correlated to morbidity and mortality due to pulmonary and cardiovascular diseases and cancer. Mitigating the toxic effects of PM2.5 is therefore highly desired. Bufei Huoxue (BFHX) capsules have been used in China to treat pulmonary heart disease (cor pulmonale). Thus, we assessed the effects of BFHX capsules on PM2...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28335878/psychotic-symptoms-in-attention-deficit-hyperactivity-disorder-an-analysis-of-the-mta-database
#20
Benedetto Vitiello, Guillermo Perez Algorta, L Eugene Arnold, Andrea L Howard, Annamarie Stehli, Brooke S G Molina
OBJECTIVE: To assess the prevalence of psychotic symptoms among youths (14-25 years of age) with a childhood diagnosis of attention-deficit/hyperactivity disorder (ADHD) combined type. METHOD: Participants in the Multimodal Treatment Study of Children with ADHD (MTA) and a local normative comparison group (LNCG) were systematically assessed 6, 8, 10, 12, 14, and 16 years after the original enrollment at a mean age of 8.5 years. Trained research assistants administered a psychosis screener, and positive screens were referred to study clinicians to confirm or exclude psychosis...
April 2017: Journal of the American Academy of Child and Adolescent Psychiatry
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