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Glucomannan

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https://www.readbyqxmd.com/read/28586481/dietary-fiber-and-digestive-health-in-children
#1
Renee Korczak, Alison Kamil, Lisa Fleige, Sharon M Donovan, Joanne L Slavin
Digestive health is an expanding area in nutrition research due to the interest in how food components such as fiber affect gastrointestinal tolerance, stool form, defecation frequency, transit time, and gut microbial composition and metabolic activity. In children, however, digestive health studies that intervene with dietary fiber are limited due to legal and ethical concerns. To better understand if fiber improves digestive health in children, a literature review was conducted to answer the following research question: What are the effect(s) of fiber-containing foods and/or supplements on digestive health outcomes in children? A search of the PubMed database identified a total of 12 studies that fit the inclusion criteria established for this review...
April 1, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/28582717/modulating-the-phenotype-of-host-macrophages-to-enhance-osteogenesis-in-msc-laden-hydrogels-design-of-a-glucomannan-coating-material
#2
Yiming Niu, Qiu Li, Ruiyu Xie, Shang Liu, Ruibing Wang, Panfei Xing, Yuchen Shi, Yitao Wang, Lei Dong, Chunming Wang
The biomaterials-host interaction is a dynamic process in which macrophages play a vital role of regulation. Depending on the biochemical signals they sense, these highly plastic cells can mediate the immune response against the implanted scaffolds and/or exert regenerative potency to varying extent. Designing appropriate 'exterior signals' for scaffolds may exploit the power of endogenous macrophages to aid the regeneration of engineered tissues. To realise this goal, this study devised an injectable, instantaneously-solidifying coating material (acBSP) based on a unique, macrophage-affinitive glucomannan polysaccharide...
September 2017: Biomaterials
https://www.readbyqxmd.com/read/28579175/an-exopolysaccharide-eps-from-a-lactobacillus-plantarum-br2-with-potential-benefits-for-making-functional-foods
#3
Keerthi Sasikumar, Deepti Kozhummal Vaikkath, Leena Devendra, K Madhavan Nampoothiri
A high molecular weight EPS of glucomannan nature was recovered and purified to get an yield of 2.8±0.5g/L from Lb. plantarum BR2 and it displayed potent antioxidant activity with 29.8% radical scavenging activity and 19% total antioxidant capacity. At 100µg/ml concentration, it is capable of inhibiting the alpha amylase activity by 10% and at 300µg/ml, it drastically inhibited the alpha-glucosidase activity by 67% which indicates its antidiabetic potential. More interestingly, at a concentration level of 0...
May 17, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28578975/ph-sensitive-drug-delivery-system-based-on-hydrophobic-modified-konjac-glucomannan
#4
Jinling Luan, Kao Wu, Cao Li, Jia Liu, Xuewen Ni, Man Xiao, Yanglin Xu, Ying Kuang, Fatang Jiang
Amphiphilic aliphatic amines grafted konjac glucomannan (KGM-g-AH8, KGM-g-AH12 and KGM-g-AH18) micelles were prepared via a simple two-step synthesis with Schiff's base as the "switch" to achieve intracellular acid-triggered curcumin release. The KGM-g-AH8 self-assembled into spherical nano-micelles (107.6±11.6nm) in an aqueous medium, and presented high curcumin loading capacity as well as good physical stability in 28 days. The in vitro curcumin release behaviors proved the controlled release property and the endosomal/lysosomal pH response of KGM-g-AH8 micelles...
September 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28559619/evaluation-of-different-hydrocolloids-to-improve-dough-rheological-properties-and-bread-quality-of-potato-wheat-flour
#5
Xingli Liu, Taihua Mu, Karim Diego Yamul, Hongnan Sun, Miao Zhang, Jingwang Chen, Marie Laure Fauconnier, Perez Vanina Andrea
The aim of study was to investigate the effect of hydroxylpropylmethylcellulose (HPMC), arabic gum (AG), konjac glucomannan (KG) and apple pectin (AP) at 2% (w/w, potato-wheat flour basis) on the potato-wheat dough (the mass ratio was 1:1) rheological, fermentation and bread making properties. The tan δ of potato-wheat dough was significantly increased upon addition of adding HPMC which was close to wheat dough (0.531). Moreover, dough height during fermentation process was significantly improved on addition of hydrocolloids, with the order of HPMC (23...
May 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28535423/chromatographic-separation-and-detection-methods-of-aloe-arborescens-miller-constituents-a-systematic-review
#6
REVIEW
Jilan A Nazeam, Haidy A Gad, Hala M El-Hefnawy, Abdel-Naser B Singab
Aloe arborescens Miller (Family Asphodelaceae) is a member of genus Aloe, which is used in traditional medicine to cure various diseases. The extracts of the plant have been reported to possess anticancer, immunomodulator, antidiabetic, anti-inflammatory and antioxidant activities. The phytochemical investigations have revealed diverse chemical constituents, including phenolics [anthraquinones, anthrones, pyrones, chromones and coumarins], polysaccharides [arborans [(1-4) linked glucomannans, polysaccharide (A, B and C): (A: a linear (1-6)-O-α-glucan, B: a branching (1-2)-O-l-arabinose with (1-2)-O-d-galactose linkages and C: (1-4)-O-β-mannan with 18% acetyl group)]], glycoproteins and carboxypeptidase enzyme...
April 29, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28504162/purification-of-glucomannan-from-salep-part-2-structural-characterization
#7
Abdullah Kurt, Talip Kahyaoglu
The aim of this study was to investigate the effects of different extraction temperatures (25, 55 and 85°C) on the structural characteristics of glucomannan (GM) purified from salep. All extraction conditions reduced protein content and molecular weight of salep. The effectiveness of removing the impurities and the highest purity of GM25 were observed with size exclusion profile. FTIR experiments demonstrated the presence of acetyl group, reduction of protein content and increment of polymer interaction of GM25...
August 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28489527/role-of-glucomannans-in-immunology
#8
Richard Tester, Farage H Al-Ghazzewi
Glucomannans play a much broader role in human health then providing dietary fibre. They are biologically active molecules and can when added to the body imitate innate molecules found in different organs including surface carbohydrates on cells. This review considers the immunological role of exogenous glucomannans within animals and man. This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page.
2017: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28472600/glucomannan-or-glucomannan-plus-spirulina-enriched-squid-surimi-diets-reduce-histological-damage-to-liver-and-heart-in-zucker-fa-fa-rats-fed-a-cholesterol-enriched-and-non-cholesterol-enriched-atherogenic-diet
#9
Miguel Vázquez-Velasco, Laura González-Torres, Rosa A García-Fernández, María Teresa Méndez, Sara Bastida, Juana Benedí, María José González-Muñoz, Francisco J Sánchez-Muniz
Glucomannan-enriched squid surimi improves cholesterolemia and liver antioxidant status. The effect of squid surimi enriched with glucomannan or glucomannan plus spirulina on liver and heart structures and cell damage markers was tested in fa/fa rats fed highly saturated-hyper-energetic diets. Animals were fed 70% AIN-93M rodent diet plus six versions of 30% squid surimi for 7 weeks: control (C), glucomannan (G), and glucomannan plus spirulina (GS). The cholesterol-control (HC), cholesterol-glucomannan (HG), and cholesterol-glucomannan plus spirulina (HGS) groups were given similar diets that were enriched with 2% cholesterol and 0...
June 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28462052/cloning-and-evaluation-of-reference-genes-for-quantitative-real-time-pcr-analysis-in-amorphophallus
#10
Kai Wang, Yi Niu, Qijun Wang, Haili Liu, Yi Jin, Shenglin Zhang
Quantitative real-time reverse transcription PCR (RT-qPCR) has been widely used in the detection and quantification of gene expression levels because of its high accuracy, sensitivity, and reproducibility as well as its large dynamic range. However, the reliability and accuracy of RT-qPCR depends on accurate transcript normalization using stably expressed reference genes. Amorphophallus is a perennial plant with a high content of konjac glucomannan (KGM) in its corm. This crop has been used as a food source and as a traditional medicine for thousands of years...
2017: PeerJ
https://www.readbyqxmd.com/read/28460917/healthy-spanish-salchich%C3%A3-n-enriched-with-encapsulated-n-3-long-chain-fatty-acids-in-konjac-glucomannan-matrix
#11
Jose M Lorenzo, Paulo Eduardo Sichetti Munekata, Mirian Pateiro, Paulo Cezar Bastianello Campagnol, Ruben Domínguez
Reduction of fat content and improving fatty acid composition were the strategies used to reformulate Spanish salchichón with better lipid content by partial substitution of pork backfat by microencapsulated fish oil in konjac glucomannan matrix. For the present study, four different batches were manufactured: control (CO) with 100% of pork backfat and ME25, ME50 and ME75 where the pork backfat was replaced with 25, 50 and 75% by microencapsulated fish oil, respectively. The fat replacement by microencapsulated fish oil was accompanied by a decrease (P<0...
November 2016: Food Research International
https://www.readbyqxmd.com/read/28460335/a-macrophage-activating-injectable-hydrogel-to-sequester-endogenous-growth-factors-for-in-situ-angiogenesis
#12
Yanxian Feng, Qiu Li, Dang Wu, Yiming Niu, Cheng Yang, Lei Dong, Chunming Wang
Biomaterials scaffolds designed for many regenerative applications are expected to support neo-vascularisation, which is now being hampered by two limitations - the instability of exogenous growth factors (GFs) that are delivered to promote angiogenesis; and the loss of extracellular matrix components that bind and stabilise GFs. Here, we report the design and evaluation of an injectable hydrogel system aimed at restoring a GF-binding microenvironment to enhance the pro-angiogenic functions of endogenous GFs...
April 25, 2017: Biomaterials
https://www.readbyqxmd.com/read/28457433/purification-of-glucomannan-from-salep-part-1-detailed-rheological-characteristics
#13
Abdullah Kurt, Talip Kahyaoglu
The aim of this study was to investigate the effects of different extraction temperatures (25, 55 and 85°C) on the rheological characteristics of glucomannan (GM) purified from salep. GM was isolated using the following method: extraction of GM with water, removal of impurities by centrifugation and precipitation of GM with ethanol. The extraction yield of GM was approximately 45% for all products. Higher GM (95%) and lower starch (3%) contents were obtained for GM25. GM25 showed higher apparent and intrinsic viscosity, storage and loss modulus and lower activation energy than GM55 and GM85...
July 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28450022/physicochemical-properties-and-cellular-protection-against-oxidation-of-degraded-konjac-glucomannan-prepared-by-%C3%AE-irradiation
#14
Wenjie Jian, Liying Tu, Lanlan Wu, Hejian Xiong, Jie Pang, Yuan-Ming Sun
Konjac glucomannan (KGM) is an important functional polysaccharide in food research. However, unstable dispersibility of KGM inhibits its in-depth study and wide application. In this study, a degraded KGM (100kGy-KGM), which showed excellent dispersibility and specific physicochemical properties, were obtained by γ-irradiation in a dosage of 100kGy. We investigated the protective effect of 100kGy-KGM against H2O2 induced oxidative damage in LO2 cells. Our results demonstrated that pretreatment of LO2 cells with 100kGy-KGM not only significantly increased cellular survivals and activities of GSH-Px and CAT, but also reduced levels of LDH, MDA and intracellular accumulation of ROS...
September 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28429913/effect-of-glucomannan-on-functional-constipation-in-children-a-systematic-review-and-meta-analysis-of-randomised-controlled-trials
#15
Yong Han, Lei Zhang, Xiang-Qun Liu, Zhi-Jun Zhao, Lu-Xian Lv
BACKGROUND AND OBJECTIVES: Constipation, a common complaint in children, considerably affects the quality of life. This systematic review assessed the treatment effects of glucomannan on children with constipation by summarising evidence from previous randomised controlled trials (RCTs). METHODS AND STUDY DESIGN: A comprehensive electronic literature search was conducted for identifying eligible RCTs that evaluated the effectiveness of glucomannan. The results were reported as mean differences (MDs), standardised mean differences (SMDs), and risk ratios (RRs) with 95% confidence intervals (CIs)...
May 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28408313/preventing-cardiovascular-heart-disease-promising-nutraceutical-and-non-nutraceutical-treatments-for-cholesterol-management
#16
REVIEW
T P Johnston, T A Korolenko, M Pirro, A Sahebkar
Hypercholesterolemia is one of the major risk factors for the development of cardiovascular disease. Atherosclerosis resulting from hypercholesterolemia causes many serious cardiovascular diseases. Statins are generally accepted as a treatment of choice for lowering low-density lipoprotein (LDL) cholesterol, which reduces coronary heart disease morbidity and mortality. Since statin use can be associated with muscle problems and other adverse symptoms, non-adherence and discontinuation of statin therapy often leads to inadequate control of plasma cholesterol levels and increased cardiovascular risk...
June 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28372193/effects-of-konjac-glucomannan-on-heat-induced-changes-of-wheat-gluten-structure
#17
Yu Wang, Yiheng Chen, Yun Zhou, Satoru Nirasawa, Eizo Tatsumi, Xiuting Li, Yongqiang Cheng
Effects of konjac glucomannan on the structure of wheat gluten were investigated at variable temperatures in this study. Dynamic oscillatory rheology study showed that konjac glucomannan conferred stiffness on gluten with a higher tan δ data at 25°C and 55°C, but this parameter was lower at 75°C and 95°C. Konjac glucomannan decreased the content of thiol equivalent groups and increased the α-helix/β-sheet content ratio, respectively. The thicker layer of gluten protein with 5% konjac glucomannan was observed by scanning electron microscopy...
August 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28363561/a-kinetic-model-of-the-gelation-of-konjac-glucomannan-induced-by-deacetylation
#18
Ching-Feng Mao, Cheng-Ho Chen
The gelation of konjac glucomannan (KGM) often involves an induction period featured by an initial drop in modulus. The gelation kinetics recorded as a time-dependent modulus change is composed of an initial drop followed by a steady increase in modulus until an equilibrium stage is reached. In this work, the time-dependent modulus curve is described by a kinetic model which incorporates the cascade theory with the kinetic equations consisting of sequential reactions of deacetylation and cross-link formation...
June 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28356275/a-systematic-review-and-meta-analysis-of-randomized-controlled-trials-of-the-effect-of-konjac-glucomannan-a-viscous-soluble-fiber-on-ldl-cholesterol-and-the-new-lipid-targets-non-hdl-cholesterol-and-apolipoprotein-b
#19
Hoang Vi Thanh Ho, Elena Jovanovski, Andreea Zurbau, Sonia Blanco Mejia, John L Sievenpiper, Fei Au-Yeung, Alexandra L Jenkins, Lea Duvnjak, Lawrence Leiter, Vladimir Vuksan
Background: Evidence from randomized controlled trials (RCTs) suggests the consumption of konjac glucomannan (KJM), a viscous soluble fiber, for improving LDL-cholesterol concentrations. It has also been suggested that the cholesterol-lowering potential of KJM may be greater than that of other fibers. However, trials have been relatively scarce and limited in sample size and duration, and the effect estimates have been inconsistent. The effect of KJM on new lipid targets of cardiovascular disease (CVD) risk is also unknown...
May 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28325998/glucomannan-and-glucomannan-plus-spirulina-enriched-pork-affect-liver-fatty-acid-profile-ldl-receptor-expression-and-antioxidant-status-in-zucker-fa-fa-rats-fed-atherogenic-diets
#20
Laura González-Torres, Cátia Matos, Miguel Vázquez-Velasco, Jorge A Santos-López, Iria Sánchez-Martínez, Camino García-Fernández, Sara Bastida, Juana Benedí, Francisco J Sánchez-Muniz
We evaluated the effects of glucomannan or glucomannan plus spirulina-restructured pork (RP) on liver fatty acid profile, desaturase/elongase enzyme activities and oxidative status of Zucker fa/fa rats for seven weeks. Control (C), glucomannan (G) and glucomannan/spirulina (GS)-RP; HC (cholesterol-enriched control), HG and HGS (cholesterol-enriched glucomannan and glucomannan/spirulina-RP) experimental diets were tested. Increased metabolic syndrome markers were found in C, G and GS rats. Cholesterol feeding increased liver size, fat, and cholesterol and reduced antioxidant enzyme levels and expressions...
2017: Food & Nutrition Research
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