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Lingli Hu, Zhencheng Liao, Qiqi Hu, Katherine G Maffucci, Yan Qu
Dissolving microneedles (MNs) have been widely studied for their applications in effective transdermal drug delivery due to their ability to dissolve within the skin. This study details the first reported successful preparation of novel dissolving MNs using Bletilla striata polysaccharide (BSP), a natural glucomannan material, and investigates the potential for using such MNs as a transdermal drug delivery vector. The prepared dissolving Bletilla striata polysaccharide microneedles (BMNs) had excellent moldability and were easily detached from the mold...
May 15, 2018: International Journal of Biological Macromolecules
Yun-Cheng Li, Geng Zhong, Fan-Bing Meng, Hua Yu, Da-Yu Liu, Lian-Xin Peng
BACKGROUND: Konjac glucomannan octenyl succinate (KGOS) has excellent emulsification properties and can potentially be used in the food industry as an emulsifier, stabilizer and microcapsule wall material. In present study, the in vitro digestion properties and emulsification capability and stability of KGOS were studied to evaluate the transport and encapsulation characteristics of KGOS to insoluble bioactive nutrients. RESULTS: Confocal scanning laser microscopy (CSLM) suggested that oil droplets could be encapsulated by KGOS into regular spheres...
May 15, 2018: Journal of the Science of Food and Agriculture
Hiroshi Nishimura, Akihiro Kamiya, Takashi Nagata, Masato Katahira, Takashi Watanabe
Cross-linking between lignin and polysaccharide in plant cell-wall determines physical, chemical, and biological features of lignocellulosic biomass. Since Erdmann's first report in 1866, numerous studies have suggested the presence of a bond between hemicelluloses and lignin; however, no clear evidence for this interaction has been reported. We describe the first direct proof of covalent bonding between plant cell-wall polysaccharides and lignin. Nuclear magnetic resonance spectroscopy was used to observe the long-range correlations through an α-ether bond between lignin and the primary hydroxyl group of a mannose residue in glucomannan...
April 25, 2018: Scientific Reports
Yi Yuan, Lin Wang, Ruo-Jun Mu, Jingni Gong, Yuyan Wang, Yuanzhao Li, Jiaqi Ma, Jie Pang, Chunhua Wu
Pure agarose (AG) hydrogels have strong rigidity and brittleness, which greatly limit their applications. Therefore, in this study, konjac glucomannan (KGM) was used to improve the properties of AG hydrogels. The effect of KGM on the structure and properties of AG hydrogels was investigated by rotational rheometry, Fourier Transform Infrared Spectroscopy, X-ray Diffraction, and Scanning Electron Microscopy. The results showed that the flexibility of the composite hydrogels increases with KGM concentration, which may be attributed to a synergistic interaction between KGM and AG resulting in a compact network structure...
June 15, 2018: Carbohydrate Polymers
Fan Zhu
Konjac glucomannan (KGM) is a major polysaccharide from the corm of Amorphophallus konjac. Native KGM has limited uses and has been chemically/physically/enzymatically modified to expand the range of functional properties. This mini-review summarises the recent advances of modifying KGM for diverse food and nonfood applications, focusing on the chemical and physical modifications. The chemical methods include substitution, grafting, cross-linking, oxidation, and deacetylation, whereas the physical modifications are electrospinning, microfluidic spinning, γ-irradiation, extrusion, and electric field processing...
August 1, 2018: Food Chemistry
Wenjie Jian, Yung-Husan Chen, Liangyu Wang, Liying Tu, Hejian Xiong, Yuan-Ming Sun
Konjac glucomannan (KGM) is an important source for preparation of Konjac oligo-glucomannan (KOG), but high molecular weight and viscosity in KGM inhibited its full degradation into KOG. In this study, KOG with a degree of polymerization between 2 and 9 was obtained by combining γ-irradiation and enzymatic hydrolysis in high yield. We investigated the protective effect of KOG against H2 O2 - induced oxidative damage in vitro, using human hepatic cell line (LO2) as a cell model. Our results demonstrated that pretreating LO2 with KOG significantly increases cellular survival and antioxidant activities of GSH-Px and CAT enzymes, and reduces levels of LDH, MDA, intracellular accumulation of ROS and Ca2+ concentration within the cell...
May 2018: Food Research International
Shuhong Dai, Fatang Jiang, Harold Corke, Nagendra P Shah
Konjac glucomannan (KGM) is a natural polysaccharide with several favorable nutritional characteristics, and exhibits functional properties as a potential fat-replacer in dairy products. In our study, composition, color and browning (L*, a* and b* before and after heating), and textural characteristics of low-fat and skimmed Mozzarella cheese with KGM (LFKGM and SKKGM) were compared with those of full-fat, low-fat and skimmed Mozzarella cheese controls (FFC, LFC and SKC) after 0, 7, 14, 21 and 28 days of storage at 4 °C...
May 2018: Food Research International
Sato Ryosuke, Gaku Yamaguchi, Daisuke Nagai, Yasuyuki Maki, Kazuto Yoshiba, Takao Yamamoto, Benjamin Chu, Toshiaki Dobashi
A nonwoven fabric of Konjac glucomannan (KGM) for the adsorption of tannin was fabricated by using electrospinning and then followed by deacetylation with alkaline solution. To analyze the adsorption dynamics of tannin, the time course of the adsorption of tannin on the nonwoven KGM fabric was measured by immersing the fabric in tannin solution at different concentrations of tannin and amounts of the fabric. The initial and late stages of the adsorption behavior could be expressed, respectively, by using a diffusion-limited equation and a stoichiometric equation...
March 22, 2018: Soft Matter
Na Chen, Pei Zhu, Ting Du, Kai Han, Dang Wang, Jianfeng Ye, Shaobo Xiao, Xiaozhou Ye, Yun Wang
PURPOSE: Herein, we reported a facile strategy for synthesis of two types of modified konjac glucomannan nanoparticles (NPs). The goal of this project was to explore the potential of the NPs as vaccine adjuvants. METHODS: Firstly, anionic carboxymethylated konjac glucomannan (CKGM) and cationic quaternized konjac glucomannan (QKGM) were synthesized by chemical modification of konjac glucomannan (KGM). Subsequently, two types of NPs, CKGM/QKGM and sodium tripolyphosphate (TPP)/QKGM, were prepared through polyelectrolyte complex method and ionic cross-linking method, respectively...
March 20, 2018: Pharmaceutical Research
Xuewen Ni, Kai Wang, Kao Wu, Harold Corke, Katsuyoshi Nishinari, Fatang Jiang
This study aims to investigate the stability, microstructure and rheological properties of konjac glucomannan (KGM)/zein mixed systems in different mixing ratios. A phase diagram was established by centrifugation and visual observation. KGM/zein could form a stable homogeneous dispersion with appropriate mixing formula, and the particle size in mixed systems increased with increasing zein content. During storage, zein particles increased in size but were homogeneously distributed in the continuous phase of KGM without flocculation as observed by confocal light scanning microscopy...
May 15, 2018: Carbohydrate Polymers
Sakunie Sawai, Mas Sahidayana Mokhtar, Wan Kamarul Zaman Wan Safwani, Thamil Selvee Ramasamy
BACKGROUND: Konjac glucomannan (KGM) is a water-soluble dietary fibre extracted from Amorphophallus konjac K. Koch (Araceae). Konjac fibre has been clinically proven as an effective antioxidant agent in weight control but its traditionally known tumour suppression property remains to be explored. OBJECTIVE: The main objective of this study is to determine the potential anti-proliferative effect of KGM on cancer and normal human liver cell lines, HepG2 and WRL68, respectively...
March 7, 2018: Anti-cancer Agents in Medicinal Chemistry
Praveen Krishna Veerasubramanian, Ponrasu Thangavel, Ramya Kannan, Sudip Chakraborty, Balaji Ramachandran, Lonchin Suguna, Vignesh Muthuvijayan
We have developed a novel hydrogel composed of konjac glucomannan (KGM), human hair proteins (KER), and an ethanolic extract of Avena sativa (OAT) and evaluated its potential as a dressing material for diabetic wounds. KGM is an excellent biocompatible gelling agent that stimulates fibroblast proliferation and immunomodulation. Human hair proteins (KER) are biocompatible, biodegradable, and possess abundant cell adhesion sites. KER also promotes fibroblast attachment and proliferation, keratinocyte migration, and collagen expression, which can accelerate wound healing...
May 1, 2018: Colloids and Surfaces. B, Biointerfaces
Yu Xie, Zeng-Xing Yi, Jian-Xun Wang, Tong-Gang Hou, Qiong Jiang
In this paper, carboxymethyl konjac glucomannan (CMKGM) was obtained by carboxyl modification of konjac glucomannan. Then CMKGM and chitosan (CS) were crosslinked and freeze-dried to prepare CMKGM/CS composite sponges with different proportions. The structure and micromorphology of CMKGM/CS sponges were investigated by FTIR spectroscopy and SEM. The SEM results showed that the pore structure of the composite sponge gradually increased with the increase of CMKGM content. To assess the applicability of CMKGM/CS composite sponges as wound dressing, the swelling behavior, water vapor transmission rate (WVTR), biocompatibility (cytotoxicity and hemolysis) were analyzed...
June 2018: International Journal of Biological Macromolecules
Lin Wang, Yu Du, Yi Yuan, Ruo-Jun Mu, Jingni Gong, Yongsheng Ni, Jie Pang, Chunhua Wu
Intelligent hydrogels are attractive biomaterials for various applications, however, fabricating a hydrogel with both adequate self-healing ability and mechanical properties remains a challenge. Herein, a series of novel intelligent konjac glucomannan (KGM)/microcrystalline cellulose (MCC) hydrogels were prepared vis the mussel-inspired chemistry. MCC was firstly functionalized by the oxidative polymerization of dopamine, and the intelligent hydrogels were obtained by mixing aqueous solutions of KGM and functionalized MCC (PDMCC)...
July 1, 2018: International Journal of Biological Macromolecules
Wenkun Zhu, Tao Duan, Zuowen Hu
We have demonstrated there is a significant intermolecular interaction between GO and KGM that results from hydrogen bonding and physical cross-linking by studying the rheological properties of a graphene oxide/konjac glucomannan (GO/KGM) solution. When the addition of GO was 5%, the storage modulus (G') and loss modulus (G″) were only improved by 0.25%. However, G' and G″ were improved by approximately 90% and 73.4%, respectively, when the GO content was increased to 7.5%. The moduli also displayed a relationship between the power function and concentration...
May 1, 2018: Journal of Nanoscience and Nanotechnology
Fusheng Zhang, Qiao Fan, Hongyun Li, Hourong Chen, Jiong Zheng
BACKGROUND: In order to improve the compatibility of polysaccharide-protein mixtures and enhance their performance, a response surface methodology was used to optimize the preparation conditions of konjac glucomannan/casein blend gel. Moreover, the effects of high-pressure processing (HPP) on the gel properties and structure were also investigated. RESULTS: The optimal preparation parameters were a temperature of 60 °C, a total concentration 40 g kg-1 , and a dietary alkali concentration 5 g kg-1 ...
February 8, 2018: Journal of the Science of Food and Agriculture
Pirudee Tuntrakool, Suttipun Keawsompong
Endo-1,4-β-mannanase is an enzyme that can catalyze the random hydrolysis of β-1,4-mannosidic linkages in the main chain of mannans, glucomannans and galactomannans and offers many applications in different biotechnology industries. Purification and kinetic properties of the endo-1,4-β-mannanase from recombinant Escherichia coli strain KMAN-3 were examined. Recombinant β-mannanase (KMAN-3) was purified 50.5 fold using Ni-NTA Agarose resin and specific activity of 11900 U/mg protein was obtained. Purified KMAN-3 showed a single band on SDS-PAGE with a molecular weight of 43 kDa...
June 2018: Protein Expression and Purification
Andrea Maia-Landim, Juan M Ramírez, Carolina Lancho, María S Poblador, José L Lancho
BACKGROUND: Overweight and obesity are considered major health problems that contribute to increase mortality and quality of life. Both conditions have a high prevalence across the world reaching epidemic numbers. Our aim was to evaluate the effects of the administration of Garcinia cambogia (GC) and Glucomannan (GNN) on long-term weight loss in people with overweight or obesity. METHODS: Prospective, not-randomized controlled intervention trial was conducted. We treated 214 subjects with overweight or obesity with GC and GNN (500 mg twice a day, each) for 6 months evaluating weight, fat mass, visceral fat, basal metabolic rate, and lipid and glucose blood profiles comparing them with basal values...
January 24, 2018: BMC Complementary and Alternative Medicine
Pengfeng Luo, Ming Nie, Huigao Wen, Wenyan Xu, Lihong Fan, Qihua Cao
Hydrogel wound dressing is a new type of biomaterial with performance that is better than traditional and biological dressings. It has been extensively researched and the application in the field of biomedicine is common. In this study, we developed a simple and nontoxic method for preparing a new type of composite hydrogel, which formed through the Schiff-base reaction between the aldehyde of oxidized konjac glucomannan (OKGM) and the amino of carboxymethyl chitosan sulfate (CMSS). The chemical structures of this composite hydrogel were characterized by transform infrared spectroscopy (FT-IR)...
March 14, 2018: International Journal of Biological Macromolecules
Honglei Chen, Guangqian Lan, Luoxiao Ran, Yang Xiao, Kun Yu, Bitao Lu, Fangying Dai, Dayang Wu, Fei Lu
A novel Konjac glucomannan/silver nanoparticle (KGM/AgNP) composite sponge was successfully prepared via a simple 2-step method for biomedical applications as wound-healing materials. First, AgNPs were prepared with green deoxidizer egg white. Then, KGM powder was added to the AgNP solution and stirred vigorously, and the composite sponge was obtained by freeze-drying. The KGM/AgNP composite sponge showed excellent water absorption and water retention, and considerable mechanical properties. KGM/AgNP composite sponges displayed good antibacterial activity against test microorganisms...
March 1, 2018: Carbohydrate Polymers
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