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induction with misoprostol

Zahra Dehbashi, Mahmood Moosazadeh, Mahdi Afshari
BACKGROUND: Each year, more than forty million abortions are occurred whole of the world. Misoprostol is a prostaglandin analogue with a strong uterotonic effect. The present study aimed to compare the efficacy of Misoprostol in first trimester abortion through two sublingual and vaginal routes of administration. METHODS: This randomized clinical trial was conducted on 52 consecutive women in first trimester candidate for pregnancy termination because of fetal IUFD or missed abortion in sonography reports...
July 24, 2016: Materia Socio-medica
Prasanna Latha Akkenapally
OBJECTIVE: To compare the effectiveness, success rate and induction to abortion interval between administration of misoprostol only and mifepristone with misoprostol in second trimester abortions (14-20 weeks) . MATERIALS AND METHODS: The study was conducted by dividing women approaching for second trimester termination, into two groups each consisting of 100 women. Group-I received only misoprostol; 600 mcg initial vaginal insertion followed by 400 mcg sublingually every 3 h until termination...
October 2016: Journal of Obstetrics and Gynaecology of India
Gaurav Shyam Desai, Abhishek Chandavarkar, Sriram Gopal, Ganpat Sawant, Shyam V Desai
CONTEXT: Intravaginal placement of misoprostol has been used extensively to terminate second trimester pregnancies. Intracervical misoprostol is an alternative method of termination of pregnancy for women in this period of gestation. OBJECTIVE: To assess the efficacy and safety of combined intracervical and intravaginal misoprostol in the management of mid-trimester medical termination of pregnancy and to compare it with intravaginal misoprostol. MATERIALS AND METHODS: In this IRB approved prospective study, twenty-two women (mean age 25...
October 2016: Journal of Obstetrics and Gynaecology of India
Braganza Veena, Rajinish Samal, Leeberk R Inbaraj, Carolin Elizabeth George
BACKGROUND: Prostaglandins are popular agents for induction of labour, owing to their dual action of cervical ripening and inducing uterine contractions. Sublingual misoprostol offers high efficacy as it bypasses first-pass metabolism. Researchers have proved that intracervical PGE1 is as effective as PGE2 except for increased caesarean rate and hyperstimulation. Limited knowledge is available on the efficacy of sublingual PGE1 and intracervical PGE2. This study was designed to compare the effectiveness of sublingual PGE1 with intracervical PGE2...
October 2016: Journal of Obstetrics and Gynaecology of India
Cristine Kolling Konopka, Verônica Farina Azzolin, Francine Carla Cadoná, Alencar Kolinski Machado, Eduardo Bortoluzzi Dornelles, Fernanda Barbisan, Ivana Beatrice Mânica da Cruz
Misoprostol, prostaglandin E1 analogue, used for labour induction. However, one-third of patients who have labour induced with prostaglandins do not reach vaginal delivery. The differential expression of prostaglandin receptors in myometrial cells could account for this differential response. Since delivery physiology also involves modulation of oxidative metabolism that can be potentially affected by pharmacological drugs, in the present investigation the role of misoprostol on expression of prostaglandin receptors, and oxidative markers of myometrial cells was evaluated...
September 16, 2016: Prostaglandins & Other Lipid Mediators
Sven Kehl, Lena Böhm, Christel Weiss, Jutta Heimrich, Ulf Dammer, Friederike Baier, Marc Sütterlin, Matthias W Beckmann, Florian Faschingbauer
AIM: The best time to commence cervical ripening with a balloon catheter is unknown. The aim of this study was to evaluate whether application of a balloon catheter in the morning or in the evening is better when sequential prostaglandin application is planned. METHODS: This multicenter historical cohort study included 415 women with an unfavorable cervix undergoing labor induction at term. Labor was induced with a double-balloon catheter and the sequential use of oral misoprostol if necessary...
September 19, 2016: Journal of Obstetrics and Gynaecology Research
Zarko Alfirevic, Edna Keeney, Therese Dowswell, Nicky J Welton, Nancy Medley, Sofia Dias, Leanne V Jones, Gillian Gyte, Deborah M Caldwell
BACKGROUND: More than 150,000 pregnant women in England and Wales have their labour induced each year. Multiple pharmacological, mechanical and complementary methods are available to induce labour. OBJECTIVE: To assess the relative effectiveness, safety and cost-effectiveness of labour induction methods and, data permitting, effects in different clinical subgroups. METHODS: We carried out a systematic review using Cochrane methods. The Cochrane Pregnancy and Childbirth Group's Trials Register was searched (March 2014)...
August 2016: Health Technology Assessment: HTA
Nadia Ouerdiane, Nihel Tlili, Kaouther Othmani, Walid Daaloul, Abdelwaheb Masmoudi, Sonia Ben Hamouda, Badreddine Bouguerra
To evaluate the efficacy and safety of vaginal misoprostol for term labour induction. A prospective study conducted at the Department of Obstetrics and Gynecology B of hospital Charles Nicolle, Tunis, over a period of 4 months. The group of subjects, selected to represent the population of interest, were pregnant patients at term undergoing cervical ripening. Patients received 50 mcg vaginal misoprostol every 12 hours. The parameters studied were: contractile abnormalities, abnormalities of fetal heart rate (FHR), mode of delivery, delayed delivery and neonatal status...
2016: Pan African Medical Journal
P Tsikouras, Z Koukouli, B Manav, M Soilemetzidis, A Liberis, R Csorba, G Trypsianis, G Galazios
INTRODUCTION: We undertook a prospective cohort study to compare the effectiveness and safety of 50 µg misoprostol versus 3 mg dinoprostone in two vaginal doses 6 hours apart, followed if necessary by oxytocin for labor induction in low-risk post-term (> 40 weeks) pregnancies with unfavorable cervix (Bishop score ≤ 6). METHODS: Labor induction and subsequent management were conducted using a standardized protocol. The primary outcome of the study was labor induction rate...
July 2016: Geburtshilfe und Frauenheilkunde
Jameela PonMalar, Santosh Joseph Benjamin, Anuja Abraham, Swati Rathore, Visalakshi Jeyaseelan, Jiji Elizabeth Mathews
OBJECTIVE: To compare the efficacy of preinduction outpatient use of a single dose of 25 μg vaginal misoprostol between 38(1/2) and 40 weeks with that of placebo, to decrease the interval from intervention to delivery after stretch and sweep in low-risk gravid women with Bishop's score <4. METHOD: Sixty three women received 25 μg vaginal misoprostol and 63 women received placebo after stretch and sweep. RESULTS: The duration from intervention to delivery was 3...
August 26, 2016: Archives of Gynecology and Obstetrics
Lindsay Beckwith, Kristin Magner, Sara Kritzer, Carri R Warshak
PURPOSE: Assess the impact of obesity on successful cervical ripening with mechanical versus prostaglandin ripening. MATERIALS AND METHODS: We compared obese to non-obese women in an analysis stratified by induction method, prostaglandin versus mechanical. Misoprostol dosing was the same for obese and non-obese women. Pitocin was titrated to effect. Our primary outcome was failure to achieve active labor. Secondary outcomes included overall cesarean delivery rate, doses of misoprostol used and need for protocol deviation...
August 25, 2016: Journal of Maternal-fetal & Neonatal Medicine
Ibrahim Garba, Abubakar Shehu Muhammed, Zakari Muhammad, Hadiza Shehu Galadanci, Rabiu Ayyuba, Idris Sulaiman Abubakar
BACKGROUND: Induction of labor (IOL) is an artificial initiation of labor before its spontaneous onset for the purpose of delivery of the fetoplacental unit. Many factors are associated with its success in postdatism. OBJECTIVE: To compare the induction delivery intervals using transcervical Foley catheter plus oxytocin and vaginal misoprostol, and to identify the factors associated with successful induction among postdate singleton multiparae. MATERIALS AND METHODS: The study was a prospective randomized controlled trial of singleton multiparous pregnant women...
July 2016: Annals of African Medicine
Adam Bierut, Jadwiga Dowgiałło-Smolarczyk, Izabela Pieniążek, Jarosław Stelmachowski, Kinga Pacocha, Maciej Sobkowski, Oleg R Baev, Jacek Walczak
INTRODUCTION: The present study aimed to assess the costs and consequences of using an innovative medical technology, misoprostol vaginal insert (MVI), for the induction of labor (IOL), in place of alternative technologies used as a standard of care. METHODS: This was a retrospective study on cost and resource utilization connected with economic model development. Target population were women with an unfavorable cervix, from 36 weeks of gestation, for whom IOL is clinically indicated...
October 2016: Advances in Therapy
Sven Kehl, Christel Weiss, Ulf Dammer, Jutta Heimrich, Matthias W Beckmann, Florian Faschingbauer, Marc Sütterlin
OBJECTIVE: To evaluate the efficacy of induction of labour using a double-balloon catheter and, if necessary, sequential oral misoprostol without delay after removal of the catheter, in comparison with oral misoprostol alone. STUDY DESIGN: This retrospective cohort study included women undergoing induction of labour with oral misoprostol or double-balloon catheter with sequential oral misoprostol in singleton pregnancies at term. The catheter was placed in the evening and removed when there was no onset of labour within 12h...
September 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Sheeba Marwah, Supriya Gupta, Neera Parothi Batra, Vidhu Bhasin, Veena Sarna, Nirlep Kaur
INTRODUCTION: Missed miscarriages, occurring in upto 15% of all clinically recognized pregnancies are a cause of concern for the patients. Though many researchers in the past have compared the surgical and medical approaches in management of such patients, only a few have executed an appraisal of two routes of misoprostol at equal dosages in treatment of first trimester missed miscarriages. AIM: To compare the efficacy of misoprostol by vaginal and oral route, for the management of first trimester missed abortion; and to recognize the utility of misoprostol for cervical dilation prior to any surgical termination of pregnancy...
May 2016: Journal of Clinical and Diagnostic Research: JCDR
Rossana Mariana Carvalho de Paiva Marques, Alex Sandro Rolland Souza, Francisco Edson de Lucena Feitosa, Aurélio Antônio Ribeiro da Costa, Melania Maria Ramos Amorim
OBJECTIVES: To determine maternal and perinatal outcomes according to the mode of delivery in normotensive and hypertensive women bearing a live, full-term fetus, who were submitted to labor induction with misoprostol. METHODS: Retrospective cohort study. The endpoints were tachysystole, uterine hyperstimulation, indications for cesarean section, severe maternal morbidity, side effects, maternal death, 1st/5th minute Apgar, neonatal death, requirement for neonatal intensive care, and birth weight (grams)...
July 15, 2016: Hypertension in Pregnancy
Tetsuya Kawakita, Katherine L Grantz, Helain J Landy, Chun-Chih Huang, Michelle A Kominiarek
Objective To compare perinatal outcomes in women with oligohydramnios and an unfavorable cervix undergoing labor induction with misoprostol to prostaglandin E2. Study Design We conducted a secondary analysis of women with oligohydramnios undergoing labor induction in the Consortium on Safe Labor study (2002-2008). Oligohydramnios was recorded in the medical chart. We evaluated perinatal outcomes. We limited the analysis to women with an unfavorable cervix defined by simplified Bishop score ≤ 4. Misoprostol was compared with prostaglandin E2...
July 11, 2016: American Journal of Perinatology
Olusola P Aduloju, Akinyemi A Akintayo, Abiodun I Adanikin, Idowu P Ade-Ojo
BACKGROUND: Pre-induction cervical ripening greatly influences the outcome of induction of labour (IOL). AIMS: To compare the efficacy of combined Foley's catheter and vaginal misoprostol with Foley's catheter or low-dose vaginal misoprostol alone for cervical ripening. MATERIALS AND METHODS: Women with a singleton pregnancy admitted at term for cervical ripening and IOL based on clinical indication were randomised into three groups. Oxytocin augmentation was done in the groups as indicated...
July 7, 2016: Australian & New Zealand Journal of Obstetrics & Gynaecology
Lindsay Sheinfeld, Grady Arnott, Julie El-Haddad, Angel M Foster
OBJECTIVES: Although nurse practitioners (NPs) play a critical role in the delivery of reproductive health services in Canada, there is a paucity of published information regarding the reproductive health education provided in their training programs. Our study aimed to understand better the didactic and curricular coverage of abortion in Canadian NP programs. STUDY DESIGN: In 2014, we conducted a three-contact, bi-lingual (English-French) mailed survey to assess the coverage of, time dedicated to, and barriers to inclusion of 17 different areas of reproductive health, including abortion...
June 30, 2016: Contraception
Mieke L G Ten Eikelder, Marieke M van de Meent, Kelly Mast, Katrien Oude Rengerink, Marta Jozwiak, Irene M de Graaf, Marloes A G Holswilder-Olde Scholtenhuis, Frans J M E Roumen, Martina M Porath, Aren J van Loon, Eline S van den Akker, Robbert J P Rijnders, A Hanneke Feitsma, Albert H Adriaanse, Moira A Muller, Jan W de Leeuw, Harry Visser, Mallory D Woiski, Sabina Rombout-de Weerd, Gijs A van Unnik, Paula J M Pernet, Hans Versendaal, Ben W Mol, Kitty W M Bloemenkamp
Objective We assessed experience and preferences among term women undergoing induction of labor with oral misoprostol or Foley catheter. Study Design In 18 of the 29 participating hospitals in the PROBAAT-II trial, women were asked to complete a questionnaire within 24 hours after delivery. We adapted a validated questionnaire about expectancy and experience of labor and asked women whether they would prefer the same method again in a future pregnancy. Results The questionnaire was completed by 502 (72%) of 695 eligible women; 273 (54%) had been randomly allocated to oral misoprostol and 229 (46%) to Foley catheter...
June 24, 2016: American Journal of Perinatology
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