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https://www.readbyqxmd.com/read/28507529/parkinson-disease-an-evolutionary-perspective
#1
Pedro J Garcia-Ruiz, Alberto J Espay
There are two central premises to this evolutionary view of Parkinson disease (PD). First, PD is a specific human disease. Second, the prevalence of PD has increased over the course of human history. Several lines of evidence may explain why PD appears to be restricted to the human species. The major manifestations of PD are the consequence of degeneration in the dopamine-synthesizing neurons of the mesostriatal neuronal pathway. It is of note the enormous expansion of the human dopamine mesencephalic neurons onto the striatum compared with other mammals...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28503522/treadmill-exercise-alleviates-depressive-symptoms-in-rotenone-induced-parkinson-disease-rats
#2
Mal-Soon Shin, Tae-Woon Kim, Jae-Min Lee, Yun-Hee Sung, Baek-Vin Lim
Parkinson disease (PD) is characterized by selective loss of the dopaminergic neurons. The symptoms of depression following PD are closely associated with reduced activity of the serotonergic system in the dorsal raphe. We explored the antidepressive effect of exercise and its possible mechanism using the rotenone-induced PD rats. PD rats were induced by subcutaneously injection with rotenone for 14 days. The rats in the exercise groups were made to run on a treadmill for 30 min once a day during 14 consecutive days...
April 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/28491916/orthoptic-treatment-of-convergence-insufficiency-in-parkinson-s-disease-a-case-series
#3
Hélène Kergoat, Caroline Law, Estefania Chriqui, Marie-Jeanne Kergoat, Bernard-Simon Leclerc, Michel Panisset, Ronald Postuma, Elizabeth L Irving
Introduction: This study reports a case series of orthoptic treatment (OT) for convergence insufficiency (CI) in individuals with Parkinson's disease (PD). Method: We are reporting two cases of individuals with PD who completed OT for CI. Both had a confirmed diagnosis of CI, accompanied by CI-type symptomatology. They each underwent an OT program consisting of three office-based visits and 8 weeks of home-based exercises. Treatment outcome was based on the changes measured pre- versus post-OT on the near point of convergence, positive fusional vergences, and symptomatology score...
January 2017: Gerontology & Geriatric Medicine
https://www.readbyqxmd.com/read/28484505/effect-of-taichi-softball-on-function-related-outcomes-in-older-adults-a-randomized-control-trial
#4
Lin Lou, Liye Zou, Qun Fang, Huiru Wang, Yang Liu, Zuguo Tian, Yunpeng Han
The purpose of this present study was to examine the effect of Taichi softball (TCSB) on physical function in Chinese older adults. Eighty Chinese older adults were randomly assigned into either an experimental group experiencing four 90-minute TCSB sessions weekly for seven consecutive weeks or a control group. At baseline and 7 weeks later, all participants were asked to perform physical functional tests for both lower and upper limbs. Multiple separate Analyses of Variance (ANOVA) with repeated measures were applied to evaluate the effects of TCSB on function-related outcomes between baseline and postintervention in the two groups...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28479949/borg-scale-is-valid-for-ratings-of-perceived-exertion-for-individuals-with-parkinson-s-disease
#5
Amanda L Penko, Jacob E Barkley, Mandy Miller Koop, Jay L Alberts
Parkinson's disease is a neurodegenerative disease that has traditionally been treated with anti-parkinsonian medication. There is increasing evidence that exercise is beneficial to those with PD, therefore, it is necessary to validate a measure of exertion that can be implemented across exercise settings that may not have the capability to actively monitor heart rate. The aim of this project was to determine the validity of the Borg RPE scale in individuals with PD undergoing a maximal progressive cycling exercise test...
2017: International Journal of Exercise Science
https://www.readbyqxmd.com/read/28466271/exercise-as-a-positive-modulator-of-brain-function
#6
REVIEW
Karim A Alkadhi
Various forms of exercise have been shown to prevent, restore, or ameliorate a variety of brain disorders including dementias, Parkinson's disease, chronic stress, thyroid disorders, and sleep deprivation, some of which are discussed here. In this review, the effects on brain function of various forms of exercise and exercise mimetics in humans and animal experiments are compared and discussed. Possible mechanisms of the beneficial effects of exercise including the role of neurotrophic factors and others are also discussed...
May 2, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28461167/singing-lessons-for-respiratory-health-a-literature-review
#7
REVIEW
Rachel B Goldenberg
OBJECTIVE: Several studies have explored the role of music and singing as a treatment for respiratory symptoms. The objective of this paper was to review the current body of literature in regard to the use of singing as both a physiological and a psychological therapy for respiratory disease and assess the role the singing teacher might play in this treatment. STUDY DESIGN: This is a literature review, discussion of results and directions for further research. METHOD: Multiple databases were searched using keywords such as "respiratory," "physiotherapy," and "pulmonary" in conjunction with "singing...
April 28, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28445854/balance-training-in-individuals-with-parkinson-s-disease-therapist-supervised-vs-home-based-exercise-programme
#8
Elizabeth Maria Atterbury, Karen Estelle Welman
BACKGROUND: Poor locomotion and balance in Parkinson's disease (PD) often diminishes independence. Accordingly, gait is considered one of the most relevant rehabilitation outcomes, and home-based balance exercises might be a viable mode of exercise delivery for individuals with PD. However, research on PD interventions rarely indicate best practices to deliver exercises. Therefore, this study endeavoured to compare the efficacy of a home-based and therapist-supervised balance programme on gait parameters, dynamic balance, balance confidence and motivation in individuals diagnosed with PD...
April 4, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28438892/brain-metabolism-in-health-aging-and%C3%A2-neurodegeneration
#9
REVIEW
Simonetta Camandola, Mark P Mattson
Brain cells normally respond adaptively to bioenergetic challenges resulting from ongoing activity in neuronal circuits, and from environmental energetic stressors such as food deprivation and physical exertion. At the cellular level, such adaptive responses include the "strengthening" of existing synapses, the formation of new synapses, and the production of new neurons from stem cells. At the molecular level, bioenergetic challenges result in the activation of transcription factors that induce the expression of proteins that bolster the resistance of neurons to the kinds of metabolic, oxidative, excitotoxic, and proteotoxic stresses involved in the pathogenesis of brain disorders including stroke, and Alzheimer's and Parkinson's diseases...
April 24, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28436586/transesophageal-and-invasive-electrophysiologic-evaluation-in-children-with-wolff-parkinson-white-pattern
#10
Serhat Koca, Feyza Aysenur Pac, Ahmet Vedat Kavurt, Serkan Cay, Ajda Mihcioglu, Dursun Aras, Serkan Topaloglu
BACKGROUND: Risk stratification for Wolff-Parkinson-White (WPW) pattern either by non-invasive or invasive tests is important to determine whether an ablation is necessary or not. The aim was to compare non-invasive tests and invasive studies in a pediatric WPW population. METHODS: A total of 71 WPW patients [median age 14 years (IQR 11 - 16 years); 43 male] underwent Holter monitoring, exercise stress test (EST), and transesophageal electrophysiological study (TEEPS)...
April 24, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28389133/feasibility-study-effect-of-hand-resistance-exercise-on-handwriting-in-parkinson-s-disease-and-essential-tremor
#11
Mon S Bryant, Craig D Workman, Fariha Jamal, Hao Meng, George R Jackson
STUDY DESIGN: A single group, repeated measures design was used. INTRODUCTION: Tremor can lead to impaired hand function in patients with Parkinson's disease (PD) and essential tremor (ET). Difficulty with handwriting is a common complaint in these patients suffering from hand tremors. The effect of hand resistance exercise on handwriting is unknown. PURPOSE OF THE STUDY: To explore the influence of 6 weeks of home-based hand resistance exercise on handwriting in individuals with PD and ET...
April 4, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/28387447/withdrawn-interventions-for-fatigue-and-weight-loss-in-adults-with-advanced-progressive-illness
#12
REVIEW
Cathy Payne, Philip J Wiffen, Suzanne Martin
BACKGROUND: Fatigue and unintentional weight loss are two of the commonest symptoms experienced by people with advanced progressive illness. Appropriate interventions may bring considerable improvements in function and quality of life to seriously ill people and their families, reducing physical, psychological and spiritual distress. OBJECTIVES: To conduct an overview of the evidence available on the efficacy of interventions used in the management of fatigue and/or unintentional weight loss in adults with advanced progressive illness by reviewing the evidence contained within Cochrane reviews...
April 7, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28385921/the-effects-of-physical-exercise-on-non-motor-symptoms-and-on-neuroimmune-rage-network-in-experimental-parkinsonism
#13
Sofia D Viana, Inês R Pita, Cristina Lemos, Daniel Rial, Patrícia Couceiro, Paulo Rodrigues-Santos, Francisco Caramelo, Félix Carvalho, Syed F Ali, Rui D Prediger, Carlos A Fontes Ribeiro, Frederico C Pereira
Parkinson's disease (PD) prodromic stages comprise neuropsychiatric perturbations that critically compromise patient's quality of life. These non-motor symptoms (NMS) are associated with exacerbated innate immunity, a hallmark of overt PD. Physical exercise (PE) has the potential to improve neuropsychiatric deficits and to modulate immune network including receptors for advanced glycation endproducts (RAGE) and Toll-like receptors (TLRs) in distinct pathological settings. Accordingly, the present study aimed to test the hypothesis that PE i) alleviates PD NMS and ii) modulates neuroimmune RAGE-network in experimental PD...
April 6, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28349030/treadmill-exercise-alleviates-nigrostriatal-dopaminergic-loss-of-neurons-and-fibers-in-rotenone-induced-parkinson-rats
#14
Mal-Soon Shin, Tae-Woon Kim, Jae-Min Lee, Eun-Sang Ji, Baek-Vin Lim
Parkinson disease is one of the common brain diseases caused by dopaminergic neuronal loss in the substantia nigra and dopaminergic fiber loss in the striatum. In the present study, the effects of treadmill exercise on motor performance, dopaminergic loss of neurons and fibers, and α-synuclein expression in the nigrostriatum were evaluated using rotenone-induced Parkinson rats. For the induction of Parkinson rats, 3-mg/kg rotenone was injected, once a day for 14 consecutive days. Treadmill running was conducted for 30 min once a day during 14 consecutive days...
February 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/28342682/a-home-program-of-strength-training-movement-strategy-training-and-education-did-not-prevent-falls-in-people-with-parkinson-s-disease-a-randomised-trial
#15
Meg E Morris, Nicholas F Taylor, Jennifer J Watts, Andrew Evans, Malcolm Horne, Peter Kempster, Mary Danoudis, Jennifer McGinley, Clarissa Martin, Hylton B Menz
QUESTIONS: For people with idiopathic Parkinson's disease, does a 6-week, comprehensive, home exercise program reduce falls and disability and improve health-related quality of life? Is the program cost-effective? DESIGN: Randomised, controlled trial with concealed allocation and assessor blinding. PARTICIPANTS: One hundred and thirty-three community-dwelling adults with Parkinson's disease. INTERVENTION: The experimental group completed a 6-week home program comprising progressive resistance strength training, movement strategy training and falls education...
April 2017: Journal of Physiotherapy
https://www.readbyqxmd.com/read/28331638/effect-on-gait-speed-balance-motor-symptom-rating-and-quality-of-life-in-those-with-stage-i-parkinson-s-disease-utilizing-lsvt-big%C3%A2
#16
Beth Millage, Erin Vesey, Marsha Finkelstein, Mattie Anheluk
Individuals with Parkinson's Disease (PD) are often not referred to Physical Therapy (PT) until there are issues with mobility in later Hoehn and Yahr Stages. There have been no studies outlining the benefits of PT intervention in Stage I only. For persons with PD, deficits in motor function increase over time due to destruction of dopamine-producing cells. LSVT BIG, an exercise program for PD, has been shown to be effective in improving mobility. The purpose of this study was to assess participants functional improvement at a level of minimal clinically important difference (MCID) in one of four outcome measures: Gait Speed, Berg Balance Assessment, Functional Gait Assessment, and Unified Parkinson's Disease Rating Scale Motor Section...
2017: Rehabilitation Research and Practice
https://www.readbyqxmd.com/read/28321339/fatigue-and-muscle-strength-involving-walking-speed-in-parkinson-s-disease-insights-for-developing-rehabilitation-strategy-for-pd
#17
Ying-Zu Huang, Fang-Yu Chang, Wei-Chia Liu, Yu-Fen Chuang, Li-Ling Chuang, Ya-Ju Chang
Background. Problems with gait in Parkinson's disease (PD) are a challenge in neurorehabilitation, partly because the mechanisms causing the walking disability are unclear. Weakness and fatigue, which may significantly influence gait, are commonly reported by patients with PD. Hence, the aim of this study was to investigate the association between weakness and fatigue and walking ability in patients with PD. Methods. We recruited 25 patients with idiopathic PD and 25 age-matched healthy adults. The maximum voluntary contraction (MVC), twitch force, and voluntary activation levels were measured before and after a knee fatigue exercise...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28290191/effects-of-progressive-resistance-exercise-in-akinetic-rigid-parkinson-s-disease-patients-a-randomized-controlled-trial
#18
Luis Santos, Javier Fernandez-Rio, Kristian Winge, Beatriz Barragán-Pérez, Lucía González-Gómez, Vicente Rodríguez-Pérez, Vicente González-Díez, Alejandro Lucía, Eliseo Iglesias-Soler, Xurxo Dopico-Calvo, Miguel Fernández-Del-Olmo, Miguel Del-Valle, Miguel Blanco-Traba, Oscar E Suman, Javier Rodríguez-Gómez
BACKGROUND: Progressive resistance exercise (PRE) can have a positive effect in individuals with Parkinson's disease (PD). However, the effect of PRE may vary with the clinical subtype of PD. To date, no study has assessed the effects of PRE in the different subtypes of PD. AIM: The aim of the present study was to assess the effects of PRE in PD patients with akinesia and rigidity (AR-subtype). DESIGN: A randomized controlled trial was conducted...
March 13, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28270260/what-is-the-diagnostic-value-of-the-paediatric-exercise-tolerance-test-results-from-a-uk-centre
#19
Magdalena A Sajnach-Menke, Sarah C Walpole
Purpose The aim of this study was to determine whether the exercise tolerance test can provide diagnostic and prognostic information regarding children and young adults and help predict outcome. METHODS: A total of 87 patients, aged 7-29 years (median 13, mean 13.4) were selected retrospectively. They underwent exercise test at the Freeman Hospital from December, 2015 to May, 2016. There were two groups of patients - 46 had symptoms such as chest pain, palpitations, syncope, or dyspnoea on exertion and no cardiac diagnosis, and 40 patients had a cardiac diagnosis such as hypertrophic cardiomyopathy, transposition of the great arteries with post-arterial switch operation, aortic stenosis or regurgitation, tetralogy of Fallot, abnormal coronary arteries, Wolff-Parkinson-White syndrome, or supraventricular tachycardia...
March 8, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28263256/factors-associated-with-ambulatory-activity-in-de-novo-parkinson-disease
#20
Cory Christiansen, Charity Moore, Margaret Schenkman, Benzi Kluger, Wendy Kohrt, Anthony Delitto, Brian Berman, Deborah Hall, Deborah Josbeno, Cynthia Poon, Julie Robichaud, Toby Wellington, Samay Jain, Cynthia Comella, Daniel Corcos, Ed Melanson
BACKGROUND AND PURPOSE: Objective ambulatory activity during daily living has not been characterized for people with Parkinson disease prior to initiation of dopaminergic medication. Our goal was to characterize ambulatory activity based on average daily step count and examine determinants of step count in nonexercising people with de novo Parkinson disease. METHODS: We analyzed baseline data from a randomized controlled trial, which excluded people performing regular endurance exercise...
April 2017: Journal of Neurologic Physical Therapy: JNPT
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