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https://www.readbyqxmd.com/read/28231667/-association-between-body-mass-index-and-both-total-and-cause-specific-mortality-in-china-findings-from-data-through-the-china-kadoorie-biobank
#1
L X Wang, M Y Fan, C Q Yu, Y Guo, Z Bian, Y L Tan, P Pei, J S Chen, J Lyu, L M Li
Objective: To evaluate the associations between body mass index (BMI) and both total and cause-specific mortality. Methods: After excluding participants with heart disease, stroke, cancer, chronic obstructive pulmonary disease, and diabetes at baseline study, 428 593 participants aged 30-79 in the China Kadoorie Biobank study were chosen for this study. Participants were categorized into 9 groups according to their BMI status. Cox regression analysis was used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) of mortality on BMI...
February 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28230295/associations-of-domain-specific-physical-activities-with-insomnia-symptoms-among-0-5-million-chinese-adults
#2
Bang Zheng, Canqing Yu, Liling Lin, Huaidong Du, Jun Lv, Yu Guo, Zheng Bian, Yiping Chen, Min Yu, Jianguo Li, Junshi Chen, Zhengming Chen, Liming Li
Previous studies have demonstrated the association between physical activity and sleep quality. However, there is little evidence regarding different domains of physical activity. This study aimed to examine the associations between domain-specific physical activities and insomnia symptoms among Chinese men and women. Data of 452 024 Chinese adults aged 30-79 years from the China Kadoorie Biobank Study were analysed. Insomnia symptoms were assessed with self-reported difficulties in initiating or maintaining sleep, early morning awakening, daytime dysfunction and any insomnia symptoms...
February 23, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28229460/phenome-wide-association-studies-a-new-method-for-functional-genomics-in-humans
#3
Dan M Roden
In experimental physiology research, a common study design for examining the functional role of a gene or a genetic variant is to introduce that genetic variant into a model organism (such as yeast or mouse) and then to search for phenotypic consequences. The development of DNA biobanks linked to dense phenotypic information enables such an experiment to be applied to human subjects in form of a phenome-wide association study (PheWAS). The PheWAS paradigm takes advantage of a curated medical phenome, often derived from electronic health records, to search for associations between "input functions" and phenotypes in an unbiased fashion...
February 23, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28227083/creating-virtual-ards-patients
#4
Anup Das, Mainul Haque, Marc Chikhani, Wenfei Wang, Jonathan G Hardman, Declan G Bates, Anup Das, Mainul Haque, Marc Chikhani, Wenfei Wang, Jonathan G Hardman, Declan G Bates, Wenfei Wang, Declan G Bates, Anup Das, Mainul Haque, Marc Chikhani, Jonathan G Hardman
This paper presents the methodology used in patient-specific calibration of a novel highly integrated model of the cardiovascular and pulmonary pathophysiology associated with Acute Respiratory Distress Syndrome (ARDS). We focus on data from previously published clinical trials on the static and dynamic cardio-pulmonary responses of three ARDS patients to changes in ventilator settings. From this data, the parameters of the integrated model were identified using an optimization-based methodology in multiple stages...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227008/risk-prediction-for-cardiovascular-disease-using-ecg-data-in-the-china-kadoorie-biobank
#5
Yanting Shen, Yang Yang, Sarah Parish, Zhengming Chen, Robert Clarke, David A Clifton, Yanting Shen, Yang Yang, Sarah Parish, Zhengming Chen, Robert Clarke, David A Clifton, Yang Yang, Zhengming Chen, Yanting Shen, David A Clifton, Robert Clarke, Sarah Parish
We set out to use machine learning techniques to analyse ECG data to improve risk evaluation of cardiovascular disease in a very large cohort study of the Chinese population. We performed this investigation by (i) detecting "abnormality" using 3 one-class classification methods, and (ii) predicting probabilities of "normality", arrhythmia, ischemia, and hypertrophy using a multiclass approach. For one-class classification, we considered 5 possible definitions for "normality" and used 10 automatically-extracted ECG features along with 4 blood pressure features...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225792/the-adamts9-gene-is-associated-with-cognitive-aging-in-the-elderly-in-a-taiwanese-population
#6
Eugene Lin, Shih-Jen Tsai, Po-Hsiu Kuo, Yu-Li Liu, Albert C Yang, Chung-Feng Kao, Cheng-Hung Yang
Evidence indicates that the pathophysiologic mechanisms associated with insulin resistance may contribute to cognitive aging and Alzheimer's diseases. In this study, we hypothesize that single nucleotide polymorphisms (SNPs) within insulin resistance-associated genes, such as the ADAM metallopeptidase with thrombospondin type 1 motif 9 (ADAMTS9), glucokinase regulator (GCKR), and peroxisome proliferator activated receptor gamma (PPARG) genes, may be linked with cognitive aging independently and/or through complex interactions in an older Taiwanese population...
2017: PloS One
https://www.readbyqxmd.com/read/28224398/development-of-imaging-biomarkers-and-generation-of-big-data
#7
Ángel Alberich-Bayarri, Rafael Hernández-Navarro, Enrique Ruiz-Martínez, Fabio García-Castro, David García-Juan, Luis Martí-Bonmatí
Several image processing algorithms have emerged to cover unmet clinical needs but their application to radiological routine with a clear clinical impact is still not straightforward. Moving from local to big infrastructures, such as Medical Imaging Biobanks (millions of studies), or even more, Federations of Medical Imaging Biobanks (in some cases totaling to hundreds of millions of studies) require the integration of automated pipelines for fast analysis of pooled data to extract clinically relevant conclusions, not uniquely linked to medical imaging, but in combination to other information such as genetic profiling...
February 21, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28223083/characteristics-and-prognosis-of-japanese-female-breast-cancer-patients-the-biobank-japan-project
#8
Koshi Nakamura, Emiko Okada, Shigekazu Ukawa, Makoto Hirata, Akiko Nagai, Zentaro Yamagata, Yutaka Kiyohara, Kaori Muto, Yoichiro Kamatani, Toshiharu Ninomiya, Koichi Matsuda, Michiaki Kubo, Yusuke Nakamura, Akiko Tamakoshi
BACKGROUND: Breast cancer is currently the most common type of cancer in Japanese females. Unlike most other types of cancer, breast cancer develops more frequently in middle-aged females than in elderly females. METHODS: Of all Japanese female breast cancer patients aged ≥20 years whom the BioBank Japan Project originally enrolled between 2003 and 2008, 2034 were registered within 90 days after their diagnosis. We described the lifestyle and clinical characteristics of these patients at study entry...
February 17, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28219362/erratum-to-no-regrets-young-adult-patients-in-psychiatry-report-positive-reactions-to-biobank-participation
#9
Janet L Cunningham, Manuel Zanzi, Mimmie Willebrand, Lisa Ekselius, Mia Ramklint
No abstract text is available yet for this article.
February 20, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28215481/clinical-and-histopathological-characteristics-of-patients-with-prostate-cancer-in-the-biobank-japan-project
#10
Shigekazu Ukawa, Koshi Nakamura, Emiko Okada, Makoto Hirata, Akiko Nagai, Zentaro Yamagata, Kaori Muto, Koichi Matsuda, Toshiharu Ninomiya, Yutaka Kiyohara, Yoichiro Kamatani, Michiaki Kubo, Yusuke Nakamura, Akiko Tamakoshi
BACKGROUND: Prostate cancer is the sixth leading cause of cancer-related deaths in Japan. We aimed to elucidate the clinical and histopathological characteristics of patients with prostate cancer in the BioBank Japan (BBJ) project. METHODS: Four thousand, seven hundred and ninety-three patients diagnosed with prostate cancer in the BBJ project were included. Clinical and histopathological data, including causes of death, were analyzed. Relative survival (RS) rates of prostate cancer were calculated...
February 17, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28214186/characteristics-and-prognosis-of-japanese-colorectal-cancer-patients-the-biobank-japan-project
#11
Akiko Tamakoshi, Koshi Nakamura, Shigekazu Ukawa, Emiko Okada, Makoto Hirata, Akiko Nagai, Koichi Matsuda, Yoichiro Kamatani, Kaori Muto, Yutaka Kiyohara, Zentaro Yamagata, Toshiharu Ninomiya, Michiaki Kubo, Yusuke Nakamura
BACKGROUND: Colorectal cancer is the third most common cancer worldwide, and in Japan, it is estimated that about 10% of men and 8% of women will be diagnosed with colorectal cancer during their lifetime. METHODS: We focused on 5864 participants (3699 men and 2165 women) who had colorectal cancer and were registered with BioBank Japan (BBJ) between April 2003 and March 2008. Characteristics of colon and rectal cancer patients were calculated separately. Among the enrolled patients registered in BBJ within 90 days after diagnosis, we also calculated the 5-year cumulative and relative survival rates, and estimated the effect of lifestyle factors on all-cause mortality...
February 14, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28214185/characteristics-of-patients-with-liver-cancer-in-the-biobank-japan-project
#12
Shigekazu Ukawa, Emiko Okada, Koshi Nakamura, Makoto Hirata, Akiko Nagai, Koichi Matsuda, Zentaro Yamagata, Yoichiro Kamatani, Toshiharu Ninomiya, Yutaka Kiyohara, Kaori Muto, Michiaki Kubo, Yusuke Nakamura, Akiko Tamakoshi
BACKGROUND: Liver cancer is the fifth cause of cancer-related deaths in Japan. The BioBank Japan (BBJ) project included 200,000 patients with 47 diseases and samples; their clinical information can be used for further studies. METHODS: Patients diagnosed with liver cancer (n = 1733; 1316 men, 417 women) were included. Histology, patient characteristics, clinical characteristics, and causes of death were collected. Cumulative and relative survival rates for liver cancer were calculated...
February 14, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28211485/association-of-female-reproductive-factors-with-hypertension-diabetes-and-lqtc-in-chinese-women
#13
Bayi Xu, Yequn Chen, Jianping Xiong, Nan Lu, Xuerui Tan
The association of female reproductive factors (FRFs) with cardiovascular risk factors among different population was variable and inconsistent. The objective of this study was to examine the association between FRFs and hypertension, type 2 diabetes mellitus (DM), and long heart-rate-corrected QT interval (LQTc) in Chinese post-menopausal women (Post-MW). A total of 8046 Post-MW from the China Chaoshan Biobank Cohort Study were included for analysis. Logistic regression and general linear regression models were used to estimate the association between FRFs and hypertension, DM, and LQTc...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28209242/survival-of-macrovascular-disease-chronic-kidney-disease-chronic-respiratory-disease-cancer-and-smoking-in-patients-with-type-2-diabetes-biobank-japan-cohort
#14
Hiroshi Yokomichi, Akiko Nagai, Makoto Hirata, Yutaka Kiyohara, Kaori Muto, Toshiharu Ninomiya, Koichi Matsuda, Yoichiro Kamatani, Akiko Tamakoshi, Michiaki Kubo, Yusuke Nakamura, Zentaro Yamagata
BACKGROUND: The number of patients with diabetes is increasing worldwide. Macrovascular disease, chronic kidney disease, chronic respiratory disease, cancer and smoking frequently accompany type 2 diabetes. Few data are available related to mortality of Asians with diabetes associated with these serious comorbidities. The present study aimed to quantify the excess mortality risks of type 2 diabetic patients with comorbidities. METHODS: We analysed the available records of 30,834 Japanese patients with type 2 diabetes from the BioBank Japan Project between 2003 and 2007...
February 10, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28203683/identification-of-unique-venous-thromboembolism-susceptibility-variants-in-african-americans
#15
John A Heit, Sebastian M Armasu, Bryan M McCauley, Iftikhar J Kullo, Hugues Sicotte, Jyotishman Pathak, Christopher G Chute, Omri Gottesman, Erwin P Bottinger, Joshua C Denny, Dan M Roden, Rongling Li, Marylyn D Ritchie, Mariza de Andrade
To identify novel single nucleotide polymorphisms (SNPs) associated with venous thromboembolism (VTE) in African-Americans (AAs), we performed a genome-wide association study (GWAS) of VTE in AAs using the Electronic Medical Records and Genomics (eMERGE) Network, comprised of seven sites each with DNA biobanks (total ~39,200 unique DNA samples) with genome-wide SNP data (imputed to 1000 Genomes Project cosmopolitan reference panel) and linked to electronic health records (EHRs). Using a validated EHR-driven phenotype extraction algorithm, we identified VTE cases and controls and tested for an association between each SNP and VTE using unconditional logistic regression, adjusted for age, sex, stroke, site-platform combination and sickle cell risk genotype...
February 16, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28202209/characteristics-and-prognosis-of-japanese-male-and-female-lung-cancer-patients-the-biobank-japan-project
#16
Koshi Nakamura, Shigekazu Ukawa, Emiko Okada, Makoto Hirata, Akiko Nagai, Zentaro Yamagata, Toshiharu Ninomiya, Kaori Muto, Yutaka Kiyohara, Koichi Matsuda, Yoichiro Kamatani, Michiaki Kubo, Yusuke Nakamura, Akiko Tamakoshi
BACKGROUND: In Japanese males and females, lung cancer is currently the second and fourth most common type of cancer, and the first and second leading cause of cancer-related deaths, respectively. METHODS: Of all Japanese male and female lung cancer patients aged ≥20 years whom the BioBank Japan Project originally enrolled between 2003 and 2008, 764 males and 415 females were registered within 90 days after their diagnosis. We described the lifestyle and clinical characteristics of these patients at study entry...
February 13, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28202182/implantation-and-extravillous-trophoblast-invasion-from-rare-archival-specimens-to-modern-biobanking
#17
Gerit Moser, Berthold Huppertz
Extravillous trophoblast invasion serves to attach the placenta to the uterus and to enable access to nutrients for the embryo throughout pregnancy - secretions of the uterine glands in the first trimester, maternal blood in the second and third trimester. For assessing extravillous trophoblast invasion, histology (in combination with immunohistochemistry) still plays a major role in placental research. This is especially true for the re-assessment of rare archival specimens from early human implantation sites or placenta in utero with the background of recent knowledge which may help to strengthen current hypotheses...
February 8, 2017: Placenta
https://www.readbyqxmd.com/read/28199971/association-and-interaction-effects-of-alzheimer-s-disease-associated-genes-and-lifestyle-on-cognitive-aging-in-older-adults-in-a-taiwanese-population
#18
Eugene Lin, Shih-Jen Tsai, Po-Hsiu Kuo, Yu-Li Liu, Albert C Yang, Chung-Feng Kao
Genome-wide association studies and meta-analyses implicated that increased risk of developing Alzheimer's diseases (AD) has been associated with the ABCA7, APOE, BIN1, CASS4, CD2AP, CD33, CELF1, CLU, CR1, DSG2, EPHA1, FERMT2, HLA-DRB1, HLA-DRB4, INPP5D, MEF2C, MS4A4A, MS4A4E, MS4A6E, NME8, PICALM, PLD3, PTK2B, RIN3, SLC24A4, SORL1, and ZCWPW1 genes. In this study, we assessed whether single nucleotide polymorphisms (SNPs) within these 27 AD-associatedgenes are linked with cognitive aging independently and/or through complex interactions in an older Taiwanese population...
February 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28199072/genetic-risk-score-analysis-in-early-onset-bipolar-disorder
#19
Paul E Croarkin, Joan L Luby, Kelly Cercy, Jennifer R Geske, Marin Veldic, Matthew Simonson, Paramjit T Joshi, Karen Dineen Wagner, John T Walkup, Malik M Nassan, Alfredo B Cuellar-Barboza, Leah Casuto, Susan L McElroy, Peter S Jensen, Mark A Frye, Joanna M Biernacka
OBJECTIVE: In this study, we performed a candidate genetic risk score (GRS) analysis of early-onset bipolar disorder (BD). METHODS: Treatment of Early Age Mania (TEAM) study enrollment and sample collection took place from 2003 to 2008. Mayo Clinic Bipolar Biobank samples were collected from 2009 to 2013. Genotyping and analyses for the present study took place from 2013 to 2014. The diagnosis of BD was based on Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision criteria...
February 14, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28199007/accuracy-of-claims-based-algorithms-for-epilepsy-research-revealing-the-unseen-performance-of-claims-based-studies
#20
Lidia M V R Moura, Maggie Price, Andrew J Cole, Daniel B Hoch, John Hsu
OBJECTIVE: To evaluate published algorithms for the identification of epilepsy cases in medical claims data using a unique linked dataset with both clinical and claims data. METHODS: Using data from a large, regional health delivery system, we identified all patients contributing biologic samples to the health system's Biobank (n = 36K). We identified all subjects with at least one diagnosis potentially consistent with epilepsy, for example, epilepsy, convulsions, syncope, or collapse, between 2014 and 2015, or who were seen at the epilepsy clinic (n = 1,217), plus a random sample of subjects with neither claims nor clinic visits (n = 435); we then performed a medical chart review in a random subsample of 1,377 to assess the epilepsy diagnosis status...
February 15, 2017: Epilepsia
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