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wegner vasculitis

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https://www.readbyqxmd.com/read/27766271/complete-resolution-of-wegener-s-granulomatosis-lung-granuloma-after-aortic-root-replacement
#1
Sarah-Jayne Edmondson, Saina Attaran, Ulrich P Rosendahl
Wegner's granulomatosis (WG) is an autoimmune systemic vasculitis that results in necrotizing granulomas. We report a WG patient with a lung granuloma and aortic root dilatation, who underwent aortic root replacement on cardiopulmonary bypass (CPB). Intraoperatively, the patient suffered an aortic dissection, which was repaired immediately under deep hypothermic circulatory arrest (DHCA). Follow-up imaging showed complete granuloma resolution, despite absence of immunosuppressive therapy. Immune stimulation following CPB is well described; here, the opposite was observed and DHCA effects are discussed...
February 2016: Aorta (Stamford, Conn.)
https://www.readbyqxmd.com/read/26870133/pulmonary-renal-syndrome-in-a-patient-with-vasculitis-case-report-and-review-of-literature
#2
Aijaz Zeeshan Khan Chachar, Omer Sabir, Irfan Haider, Imrana Tanvir, Kashif Rafique, Nauman Tarif
Granulomatosis with polyangiitis (GPA) previously known as Wegner's granulomatosis, is a small vessel vasculitis that preferentially involves capillaries, arterioles and venules, presenting as multisystemic disease classically with alveolar haemorrhage and renal insufficiency. We report a case of GPA diagnosed on history, clinical findings and supported by imaging and very high levels of C-ANCA. Renal biopsy confirmed the typical histopathological findings. We discuss herein the management of the case and review of literature...
November 2015: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/26586069/wegner-s-granulomatosis-developing-for-the-first-time-in-a-patient-eight-years-after-starting-maintenance-hemodialysis
#3
Ahmad Ramadan Ali, Kamel El-Reshaid
Wegener's granulomatosis is a serious autoimmune disorder characterized by necrotizing small-vessel vasculitis. It is a multisystem disease that primarily affects the lung and kidneys. Previous studies indicated few relapses of vasculitis after hemodialysis due to uremic immunosuppression. Our case report describes an end-stage renal failure patient who had developed non-caseating lung granulomata with giant cell formation and fibrinoid necrosis of arterial media that is consistent with Wegner's granulomatosis for the first time and eight years after initiation of maintenance hemodialysis...
November 2015: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/24479415/varicella-zoster-associated-retinal-and-central-nervous-system-vasculitis-in-a-patient-with-multiple-sclerosis-treated-with-natalizumab
#4
Xenia Kobeleva, Florian Wegner, Inez Brunotte, Mete Dadak, Reinhard Dengler, Martin Stangel
We report the first case of combined retinal and CNS varicella zoster-associated vasculitis in a 49-year-old patient with multiple sclerosis who had been treated with natalizumab. He presented with a progressive bilateral visual loss. The diagnosis of a vasculitis was based on the fundoscopic examination and MRI findings. We confirmed the varicella zoster virus (VZV) infection of the CNS by PCR and increased intrathecal antibody indices in the cerebrospinal fluid. The patient was stabilized with antiviral treatment, methylprednisolone, plasmapheresis and cycophosphamide...
2014: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/23814553/strawberry-gingivitis-a-diagnostic-feature-of-gingival-wegener-s-granulomatosis
#5
R Heera, Kanaram Choudhary, V T Beena, Rency Simon
Wegener's granulomatosis (WG) is an immunologically mediated inflammatory disease characterized by granulomatous vasculitis of the upper and lower aerodigestive tracts together with glomerulonephritis. We are reporting a rare case of gingival WG that presented with erythematous and painful generalized gingival enlargement. Correlation of histopathology with routine hematoxylin and eosin and special stains [Grocott-Gomori methenamine-silver nitrate and Periodic Acid Schiff (PAS)], Mantoux test, peripheral blood smear and clinical presentation were established in diagnosing this rare entity...
December 2012: Dental Research Journal
https://www.readbyqxmd.com/read/23690105/efficacy-of-core-decompression-of-femoral-head-to-treat-avascular-necrosis-in-intravenous-drug-users
#6
Seyed Mohammad Jalil Abrisham, Mohammad Reza Hajiesmaeili, Hossein Soleimani, Hamid Pahlavanhosseini
Core decompression (CD) of the femoral head is one of the effective treatments of avascular necrosis (AVN), especially in the early stages of the disease. To investigate further the value of CD in treating the AVN, this study was performed on patients with symptomatic AVN with different etiologies who were treated with CD. This study was carried out on 25 patients (with the total number of 37 femoral head) who were diagnosed AVN using X-Ray and MRI. The CD treatments for these patients were started soon after the diagnosis...
2013: Acta Medica Iranica
https://www.readbyqxmd.com/read/22169420/-clinical-and-coronary-angiographic-features-of-patients-with-systemic-vasculitis-and-coronary-artery-disease
#7
Jing Yang, Dong Xu, Zhu-jun Shen, Chong-hui Wang, Shu-yang Zhang, Zhong-jie Fan, Xiao-feng Jin, Yong Zeng, Zhen-yu Liu, Hong-zhi Xie, Quan Fang
OBJECTIVE: To evaluate the clinical and coronary angiographic features of patients with systemic vasculitis and coronary artery disease. METHOD: Fifteen patients (11 male) with systemic vasculitis and coronary artery diseases admitted to our hospital from January 1999 to October 2009 were reviewed. RESULTS: There were 6 patients with Behcet's disease, 3 patients with Churg-Strauss syndrome, 2 patients with Takayasu arteritis, 1 patient with polyarteritis nodosa, 1 patient with microscopic polyangiitis, 1 patient with Wegner's granulomatosis and 1 patient with Kawasaki disease...
August 2011: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/20495939/treatment-of-relapsing-polychondritis-with-the-tnf-alpha-antagonist-adalimumab
#8
Tobias Lahmer, Andreas Knopf, Matthias Treiber, Uwe Heemann, Klaus Thuermel
Relapsing polychondritis (RP) is a rare immune-mediated disease which is associated with inflammation in cartilaginous tissue throughout the body. Especially, the cartilaginous structures of ear, respiratory tract, nose, and joints are affected. Around 30% of the cases are associated with other diseases especially systemic vasculitis. Onset of RP is most likely between the ages of 40-60 years. This case reports the often disguised and similar symptoms of RP to Wegner's granulomatosis and the challenge of diagnosis...
November 2010: Clinical Rheumatology
https://www.readbyqxmd.com/read/18723953/mesangioproliferative-glomerulonephritis-an-important-glomerulonephritis-in-nephrotic-syndrome-of-young-adult
#9
Usha, Sunil Kumar, R G Singh, Sagar Tapas, Jai Prakash, R S Garbyal
Mesangioproliferative glomerulonephritis (MesPGN) consists 10% of the total renal biopsy of glomerulonephritis. Aim of the present study was to find out clinicopathological changes in MesPGN and differences between diffuse and focal variety. MesPGN was seen mostly in young adults with mean age of 28.63 years for males and 26.3 years for females. Male predominance was noted (M:F ratio - 1.4:1). About 70.83% patient presented with edema feet, followed by hypertension (29.19%), fever (16.66%), oliguria, nausea and vomiting (10...
July 2008: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/14655291/-treatment-of-patients-with-wegener-s-granulomatosis-or-anca-associated-vasculitis
#10
COMMENT
J W Tervaert, C A Stegeman
Standard therapy of Wegener's granulomatosis is prednisolone in combination with cyclophosphamide. Cyclophosphamide is continued for 15-18 months after diagnosis. During therapy 26% of the patients have severe or life-threatening side effects, mostly infections. Furthermore, there are multiple long-term side effects such as an increased incidence of malignancies, especially bladder carcinoma. During the last 10 years the European vasculitis study group (www.vasculitis.org) organized several randomized clinical trials to determine optimal treatment...
November 15, 2003: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/11754304/neurologic-manifestations-of-systemic-vasculitis
#11
REVIEW
Stephen E Nadeau
The clinical features, diagnosis, and treatment of polyarteritis nodosa, Kawasaki disease, hypersensitivity angiitides (including drug-related vasculitis, serum sickness, Henoch-Schönlein purpura, hypocomplementemic vasculitis and cryoglobulinemia), Wegner's granulomatosis, temporal arteritis and Takayasu's arteritis are reviewed from a neurological perspective.
February 2002: Neurologic Clinics
https://www.readbyqxmd.com/read/11194660/-wegner-granulomatosis-with-initial-manifestation-of-bilateral-granulomatous-purulent-necrotic-mastitis
#12
S Ivanov
No abstract text is available yet for this article.
1999: Khirurgiia
https://www.readbyqxmd.com/read/9261885/mechanism-s-of-interferon-inhibitory-activity-in-blood-from-patients-with-aids-and-patients-with-lupus-erythematosus-with-vasculitis
#13
J L Ambrus, J L Ambrus, S Chadha, D Novick, M Rubinstein, B Gopalakrishnan, Z Bernstein, R L Priore, K C Chadha
We have earlier reported that patients suffering from acquired immuno-deficiency syndrome (AIDS), systemic lupus erythematosus (SLE) with vasculitis, Wegner granulomatosis and certain types of late stage cancer have interferon inhibitory activity in their serum. The purpose of this study was to identify the factor(s) involved in this interferon inhibitory activity. Twenty patients with advanced AIDS, twenty patients with SLE and vasculitis and twenty normal healthy controls between ages 25-40 years were studied...
June 1997: Research Communications in Molecular Pathology and Pharmacology
https://www.readbyqxmd.com/read/6146974/-lung-tumor-and-vasculitis-in-a-37-year-old-patient
#14
R Hoffmann, U Reinhard, E Neu-Brändle, H Wegner
No abstract text is available yet for this article.
May 1984: Praxis und Klinik der Pneumologie
https://www.readbyqxmd.com/read/2155342/autoantibodies-against-myeloid-lysosomal-enzymes-in-crescentic-glomerulonephritis
#15
REVIEW
J W Tervaert, R Goldschmeding, J D Elema, M van der Giessen, M G Huitema, G K van der Hem, T H The, A E von dem Borne, C G Kallenberg
To investigate the possible association of crescentic glomerulonephritis (CGN) with autoantibodies to myeloid lysosomal enzymes, we tested sera from 35 consecutive patients with CGN without diagnostic immunohistological findings in their renal biopsy for the presence of antineutrophil cytoplasmic antibodies directed against a 29 kD antigen from azurophilic granules (29 kD-ANCA), against myeloperoxidase (MPO-ANCA) and against elastase (elastase-ANCA), using antigen-catching ELISAs with well-defined monoclonal antibodies...
February 1990: Kidney International
https://www.readbyqxmd.com/read/2043454/wegener-s-granulomatosis
#16
REVIEW
R Y Leavitt, A S Fauci
Wegner's granulomatosis is a clinicopathologic syndrome of unknown etiology characterized by granulomatous vasculitis of the upper and lower respiratory tracts and glomerulonephritis. During the period covered by this review several articles were published describing the clinical and pathologic features of Wegner's granulomatosis. Specifically, two large series are discussed reviewing the pulmonary manifestations of the disease and the histopathology of the head and neck disease associated with Wegner's granulomatosis...
February 1991: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/1941824/the-role-of-antineutrophil-cytoplasm-antibodies-anticardiolipin-antibodies-von-willebrand-factor-antigen-and-fibronectin-for-the-diagnosis-of-systemic-vasculitis
#17
L Bleil, B Manger, T H Winkler, M Herrman, G R Burmester, F E Krapf, J R Kalden
Autoantibodies directed against cytoplasmic components of neutrophil granulocytes and monocytes (c-ANCA) are a disease specific marker for Wegner's granulomatosis (WG). Autoantibodies against cardiolipin (aCl) are specific for a subgroup of autoimmune disorders, which can also be associated with systemic vasculitis. Fibronectin (Fn) and von Willebrand factor antigen (vWfAg) are produced by blood vessel endothelial cells in response to injury. We tested sera of 61 patients with various types of systemic vasculitides, sera of 13 patients with retinal vasculitis, and sera of 199 patients with rheumatic diseases for c-ANCA, aCl, Fn, and vWfAg...
August 1991: Journal of Rheumatology
https://www.readbyqxmd.com/read/1347454/classification-of-vasculitis
#18
REVIEW
B A Michel
Usually classifications of vasculitic syndromes are based on clinical and histopathologic findings because pathogenetic mechanisms are poorly understood. A subcommittee of the Diagnostic and Therapeutic Criteria Committee of the American College of Rheumatology recently developed classification criteria for seven major vasculitic disorders through the analysis of prospectively collected patient data from 48 centers. Using two classification methods, the subcommittee derived criteria for polyareritis nodosa, Churg-Strauss syndrome, Wegner's granulomatosis, hypersensitivity vasculitis, Henoch-Schönlein purpura, giant cell (temporal) arteritis, and Takayasu's arteritis...
February 1992: Current Opinion in Rheumatology
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