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mechanical low back pain

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https://www.readbyqxmd.com/read/29472134/disruption-of-cortical-synaptic-homeostasis-in-individuals-with-chronic-low-back-pain
#1
Tribikram Thapa, Thomas Graven-Nielsen, Lucinda S Chipchase, Siobhan M Schabrun
OBJECTIVE: Homeostatic plasticity mechanisms regulate synaptic plasticity in the human brain. Impaired homeostatic plasticity may contribute to maladaptive synaptic plasticity and symptom persistence in chronic musculoskeletal pain. METHODS: We examined homeostatic plasticity in fifty individuals with chronic low back pain (cLBP) and twenty-five pain-free controls. A single block (7-min) of anodal transcranial direct current stimulation ('single tDCS'), or two subsequent blocks (7-min and 5-min separated by 3-min rest; 'double tDCS'), were randomised across two experimental sessions to confirm an excitatory response to tDCS applied alone, and evaluate homeostatic plasticity, respectively...
February 9, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29470979/transcriptional-information-revealed-differentially-expressed-circular-rnas-in-facet-joint-osteoarthritis
#2
Chen Chu, Wu Chunshuai, Chen Jiajia, Zhang Jinlong, Xue Pengfei, Jiang Jiawei, Cui Zhiming
Circular RNAs are newly identified RNAs that regulate gene expression and execute various biological activities. Facet joint osteoarthritis (FJOA) is a severe facet joint cartilage degeneration disease that induces chronic low back pain to a larger population. The molecular mechanisms of FJOA, especially the presence and changes of circular RNAs in FJOA have not been investigated. In the current study, we analyzed RNA deep sequencing outcomes from healthy control group and FJOA group, identified and annotated circular RNAs, and determined the expressions of circular RNAs...
February 19, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29466396/hydrogen-sulfide-is-expressed-in-the-human-and-the-rat-cultured-nucleus-pulposus-cells-and-suppresses-apoptosis-induced-by-hypoxia
#3
Haolin Sun, Longtao Qi, Shijun Wang, Xuwen Li, Chunde Li
Apoptosis plays pivotal role in the pathogenesis of degenerative disc diseases, which is the primary contributor to low back pain. Although the role of hydrogen sulfide (H2S) in cell apoptosis is well appreciated, the effects and mechanism that H2S regulates the program death of intervertebral disc cell are not yet elucidated. In this study, we utilized the nucleus pulposus (NP) from patients with lumbar disc herniation to investigate the relationship between endogenous H2S and NP cells apoptosis in human. Furthermore, we analyzed primary rat NP cells to study the effects of exogenous H2S on hypoxia induced cell apoptosis...
2018: PloS One
https://www.readbyqxmd.com/read/29462062/back-pain-and-co-occurring-conditions-findings-from-a-nationally-representative-sample
#4
Elizabeth M Badley, Dov B Millstone, Anthony V Perruccio
STUDY DESIGN: Cross-sectional population-level health survey. OBJECTIVE: To describe the frequency of co-occurring conditions with back pain; to identify risk factors for back pain controlling for co-occurring conditions; and to examine the association between back pain and individual co-occurring conditions. SUMMARY OF BACKGROUND DATA: Back pain shares risk factors with a range of other conditions. Most studies have considered risk factors for back pain without taking into account the potential influence of co-occurring conditions...
February 16, 2018: Spine
https://www.readbyqxmd.com/read/29459120/immedicate-effects-of-core-stabilization-exercise-on-%C3%AE-endorphin-and-cortisol-levels-among-patients-with-chronic-nonspecific-low-back-pain-a-randomized-crossover-design
#5
Aatit Paungmali, Leonard Henry Joseph, Khanittha Punturee, Patraporn Sitilertpisan, Ubon Pirunsan, Sureeporn Uthaikhup
OBJECTIVE: The main objective of the study was to measure the levels of plasma β-endorphin (PB) and plasma cortisol (PC) under lumbar core stabilization exercise (LCSE), placebo and control conditions in patients with chronic nonspecific low back pain. METHODS: Twenty-four participants with chronic nonspecific low back pain participated in a randomized, placebo-controlled, crossover design study. There were 3 experimental exercise conditions: control condition (positioning in crook lying and rest), placebo condition (passive cycling in crook lying using automatic cycler), and LCSE on a Pilates device tested with a 48-hour interval between sessions by concealed randomization...
February 17, 2018: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/29456171/a-magnetic-resonance-imaging-framework-for-quantifying-intervertebral-disc-deformation-in-vivo-reliability-and-application-to-diurnal-variations-in-lumbar-disc-shape
#6
John T Martin, Alexander B Oldweiler, Charles E Spritzer, Brian J Soher, Melissa M Erickson, Adam P Goode, Louis E DeFrate
Low back pain is a significant socioeconomic burden in the United States and lumbar intervertebral disc degeneration is frequently implicated as a cause. The discs play an important mechanical role in the spine, yet the relationship between disc function and back pain is poorly defined. The objective of this work was to develop a technique using magnetic resonance imaging (MRI) and three-dimensional modeling to measure in vivo disc deformations. Using this method, we found that disc geometry was measurable with precision less than the in-plane dimensions of a voxel (≈100 µm, 10% of the MRI pixel size)...
February 9, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29455492/-relationship-between-inflammatory-cytokines-of-il-1%C3%AE-and-tnf-%C3%AE-and-intervertebral-disc-degeneration
#7
REVIEW
He Zhao, Xing Yu, Xian-Sheng Tang, Feng He, Yong-Dong Yang, Yang Xiong, Zhen-Guo Hu, Lin Xu
The inflammatory cytokines of IL-1β and TNF-α participate in the process of intervertebral disc degeneration is focused by the spine surgeons. Inflammatory cytokines represented by IL-1β and TNF-α act as the key factors in the process of intervertebral disc degeneration resulting in low back pain and radicular symptoms. Annulus fibrosus and nucleus pulposus can secrete TNF-α and IL-1β under the stimulation of mechanical injury, overstressed, genetic susceptibility and infection. The mechanism of inflammatory cytokines in intervertebral disc degeneration needs further investigation...
September 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29451665/mirror-therapy-a-potential-intervention-for-pain-management
#8
Priscilla G Wittkopf, Mark I Johnson
The consequences of chronic pain and associated disabilities to the patient and to the health care system are well known. Medication is often the first treatment of choice for chronic pain, although side effects and high costs restrict long-term use. Inexpensive, safe and easy to self-administer non-pharmacological therapies, such as mirror therapy, are recommended as adjuncts to pain treatment. The purpose of this review is to describe the principles of use of mirror therapy so it can be incorporated into a health care delivery...
November 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29449764/the-effect-of-manual-therapy-and-neuroplasticity-education-on-chronic-low-back-pain-a-randomized-clinical-trial
#9
Adriaan Louw, Kevin Farrell, Merrill Landers, Martin Barclay, Elise Goodman, Jordan Gillund, Sara McCaffrey, Laura Timmerman
Objective: To determine if a neuroplasticity educational explanation for a manual therapy technique will produce a different outcome compared to a traditional mechanical explanation. Methods: Sixty-two patients with chronic low back pain (CLBP) were recruited for the study. Following consent, demographic data were obtained as well as pain ratings for low back pain (LBP) and leg pain (Numeric Pain Rating Scale), disability (Oswestry Disability Index), fear-avoidance (Fear-Avoidance-Beliefs Questionnaire), forward flexion (fingertips-to-floor), and straight leg raise (SLR) (inclinometer)...
December 2017: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/29448253/lycorine-suppresses-endplate-chondrocyte-degeneration-and-prevents-intervertebral-disc-degeneration-by-inhibiting-nf-%C3%AE%C2%BAb-signalling-pathway
#10
Gangliang Wang, Kangmao Huang, Yangxin Dong, Shuai Chen, Jianfeng Zhang, Jiying Wang, Ziang Xie, Xianfeng Lin, Xiangqiang Fang, Shunwu Fan
BACKGROUND/AIMS: Cartilaginous endplate (CEP) degeneration is an important cause for intervertebral disc (IVD) degeneration that leads to low-back pain. The identification of compounds that may prevent CEP degeneration is of interest for the prevention of IVD degeneration. METHODS: Catabolic protease expression in the CEP of disc degeneration patients was first assessed. The toxicity, function and underlying mechanism of lycorine (LY) on CEP-derived chondrocytes degeneration were assessed in vitro by flow cytometry analysis and western blotting...
February 9, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29448220/trunk-postural-balance-and-low-back-pain-reliability-and-relationship-with-clinical-changes-following-a-lumbar-stabilization-exercise-program
#11
Ali Shahvarpour, Dany Gagnon, Richard Preuss, Sharon M Henry, Christian Larivière
Lumbar stabilization programs reduce pain and disability, but the mechanisms of action underlying this treatment are unknown. Trunk postural control during unstable sitting represents a surrogate measure of motor control mechanisms involved to maintain the dynamic stability of the spine. This exploratory study aimed to determine the reliability of trunk postural control measures over an 8-week interval, their sensitivity to low back pain status and treatment and their relationship with clinical outcomes. Trunk postural control measures were determined in patients with low back pain before and after an 8-week lumbar stabilization exercise program...
February 9, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29444776/association-between-spectral-characteristics-of-paraspinal-muscles-and-functional-disability-in-patients-with-low-back-pain-a-cohort-study
#12
Shin-Yi Chiou, Ermis Koutsos, Pantelis Georgiou, Paul H Strutton
OBJECTIVES: Characteristics of muscle activity, represented by surface electromyography (EMG), have revealed differences between patients with low back pain (LBP) and healthy adults; how they relate to functional and clinical parameters remains unclear. The purpose of the current study was to examine the correlation between frequency characteristics of EMG (analysed using continuous wavelet transform (CWT) analysis) and patients' self-rated score of disability. DESIGN AND SETTING: This is a case-control study with 15 patients with mechanical LBP without radicular symptoms...
February 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29430880/frequency-and-anatomical-distribution-of-magnetic-resonance-imaging-features-in-sacroiliac-joints-of-young-athletes-exploring-background-noise-towards-a-data-driven-definition-of-sacroiliitis-in-early-spondyloarthritis
#13
Ulrich Weber, Anne Grethe Jurik, Anna Zejden, Ejnar Larsen, Steen Hylgaard Jørgensen, Kaspar Rufibach, Christian Schioldan, Søren Schmidt-Olsen
OBJECTIVE: Low grade bone marrow edema (BME) was reported in the sacroiliac joints (SIJ) of 25% of healthy individuals and mechanical back pain patients, challenging the imaging discrimination from early spondyloarthritis (SpA). It is unknown whether stress injury in competition sports may trigger BME. We explored frequency and anatomical distribution of SIJ MRI lesions in recreational and elite athletes. METHODS: After pre-test calibration, semicoronal SIJ MRI scans of 20 recreational runners (RR) before/after running and 22 elite ice-hockey players (IP) were assessed by 3 blinded readers for BME and structural lesions using an SIJ quadrant-based module...
February 12, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29425327/sleep-disturbances-in-chronic-pain-neurobiology-assessment-and-treatment-in-physical-therapist-practice
#14
Jo Nijs, Olivier Mairesse, Daniel Neu, Laurence Leysen, Lieven Danneels, Barbara Cagnie, Mira Meeus, Maarten Moens, Kelly Ickmans, Dorien Goubert
Among people with chronic pain, insomnia is highly prevalent, closely related to the mechanism of central sensitization, characterized by low-grade neuroinflammation, and commonly associated with stress or anxiety; in addition, it often does not respond effectively to drug treatments. This review article applies the current understanding of insomnia to clinical practice, including assessment and conservative treatment of insomnia in people with chronic pain. Cognitive-behavioral therapy for insomnia can be efficacious for improvements in sleep initiation, sleep maintenance, perceived sleep quality, and pain interference with daily functioning in people with chronic pain...
February 7, 2018: Physical Therapy
https://www.readbyqxmd.com/read/29419713/exploration-of-the-inter-relationships-between-obesity-physical-inactivity-inflammation-and-low-back-pain
#15
Lukas E Hashem, Darren M Roffey, Abdulghader M Alfasi, Gabrielle D Papineau, Denise C Wai, Philippe Phan, Stephen P Kingwell, Eugene K Wai
STUDY DESIGN: Retrospective analysis wherein 103 patients were considered, and 76 patients were included: 49 were classified as CNSLBP (Study group) and 27 had identifiable cases of Specific Chronic LBP (Control group). OBJECTIVE: Elucidate markers of systemic inflammation in patients with chronic non-specific LBP (CNSLBP). SUMMARY OF BACKGROUND DATA: Mechanisms of low back pain (LBP) are poorly understood. Pro-inflammatory cytokines are increased in obesity and involved with pain modulation; we previously proposed a theoretical model of their mediating role in LBP...
February 6, 2018: Spine
https://www.readbyqxmd.com/read/29416763/dysregulation-of-yap-by-the-hippo-pathway-is-involved-in-intervertebral-disc-degeneration-cell-contact-inhibition-and-cell-senescence
#16
Cong Zhang, Feng Wang, Zhiyang Xie, Lu Chen, Arjun Sinkemani, Haomin Yu, Kun Wang, Lu Mao, Xiaotao Wu
The Hippo pathway plays important roles in wound healing, tissue repair and regeneration, and in the treatment of degenerative diseases, by regulating cell proliferation and apoptosis in mammals. Intervertebral disc degeneration (IDD) is one of the major causes of low back pain, a widespread issue associated with a heavy economic burden. However, the mechanism underlying how the Hippo pathway regulates IDD is not well understood. Here, we demonstrate that the Hippo pathway is involved in natural IDD. Activation and dephosphorylation of yes-associated protein (YAP) were observed in younger rat discs, and decreased gradually with age...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29416373/as-if-one-pain-problem-was-not-enough-prevalence-and-patterns-of-coexisting-chronic-pain-conditions-and-their-impact-on-treatment-outcomes
#17
M Gabrielle Pagé, Maude Fortier, Mark A Ware, Manon Choinière
Introduction: The presence of multiple coexisting chronic pain (CP) conditions (eg, low-back pain and migraines) within patients has received little attention in literature. The goals of this observational longitudinal study were to determine the prevalence of coexisting CP conditions, identify the most frequent ones and patterns of coexistence, investigate the relationships among patients' biopsychosocial characteristics and number of CP conditions, and determine the impact of coexisting CP conditions on treatment response...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29408090/effects-of-ralfinamide-in-models-of-nerve-injury-and-chemotherapy-induced-neuropathic-pain
#18
Xiaonan Liang, Gang Yu, Ruibin Su
Neuropathic pain is among the most common and difficult-to-treat types of chronic pain and is associated with sodium channel malfunction. The sodium channel blocker ralfinamide has exhibited potent analgesic effects in several preclinical pain models and in patients with mixed neuropathic pain syndromes (Phase II trials), but it failed to ameliorate neuropathic low back pain in Phase III trials. It is unclear whether ralfinamide is effective against neuropathic pain induced by specified etiologies. In the present study, the antinociceptive effects of ralfinamide in neuropathic pain models induced by spared nerve injury and chemotherapy were compared in a gabapentin-controlled manner...
January 30, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29403305/spotlight-on-topographical-pressure-pain-sensitivity-maps-a-review
#19
REVIEW
Francisco Alburquerque-Sendín, Pascal Madeleine, César Fernández-de-Las-Peñas, Paula Rezende Camargo, Tania Fátima Salvini
Mechanical hyperalgesia defined as decreased pressure pain thresholds (PPTs) is commonly associated with pain. In this narrative review, we report the current state of the art within topographical pressure sensitivity maps. Such maps are based on multiple PPT assessments. The PPTs are assessed by an a priori defined grid with special focus on both spatial and temporal summation issues. The grid covers the muscle or the body region of interest using absolute or relative values determined from anatomical landmarks or anthropometric values...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29403256/langerhans-cell-histiocytosis-as-an-unusual-cause-of-back-pain-in-a-child-a-case-report-and-review-of-literature
#20
Hemaswetha Balachandran, Latha M Sneha, Gopinath Menon, Julius Scott
Low back pain in children and adolescents are usually attributed to mechanical causes and faulty positions. Although most of them are self-limiting, physicians should be aware of the red flag signs that warrant complete evaluation to rule out malignant causes of back pain. As delay in the diagnosis of vertebral lytic lesion may have sequelae in the growing children, pain disproportionate to the signs should have low threshold levels for evaluation. We report a case of 6-year-old boy who presented with worsening back pain...
October 2017: Journal of Craniovertebral Junction and Spine
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