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https://www.readbyqxmd.com/read/29349867/volumetric-modulated-arc-therapy-treatment-planning-of-thoracic-vertebral-metastases-using-stereotactic-body-radiotherapy
#1
Matthew Mallory, Damodar Pokhrel, Rajeev Badkul, Hongyu Jiang, Christopher Lominska, Fen Wang
PURPOSE/OBJECTIVES: To retrospectively evaluate the plan quality, treatment efficiency, and accuracy of volumetric modulated arc therapy (VMAT) plans for thoracic spine metastases using stereotactic body radiotherapy (SBRT). MATERIALS/METHODS: Seven patients with thoracic vertebral metastases treated with noncoplanar hybrid arcs (NCHA) (1 to 2 3D-conformal partial arcs +7 to 9 IMRT beams) were re-optimized with VMAT plans using three coplanar arcs. Tumors were located between T2 and T7 and PTVs ranged between 24...
January 19, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29349614/treatment-and-outcomes-of-28-patients-with-spinal-metastasis-from-gynecological-cancer
#2
Xin Gao, Chenglong Zhao, Shaohui He, Tianqi Fan, Wei Xu, Cheng Yang, Tielong Liu, Jianru Xiao
The aim of this study was to provide some useful information concerning clinical characteristics, surgical treatment, potential contributing factor and prognostic factors for patients with gynecological cancer (GC) spinal metastasis. We reviewed 28 patients with GC spinal metastasis in our spine tumor center between July 2008 and July 2015. Surgeries were performed on 22 of them. Univariate and multivariate analyses were conducted to identify potential prognostic factors affecting spinal metastasis-free survival (SMFS) and overall survival...
January 18, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29346182/atypical-teratoid-rhabdoid-tumor-of-the-cauda-equina-in-a-child-report-of-a-very-unusual-case
#3
James M Shiflett, Betty L Herrington, David A Joyner, Ali G Saad
Atypical teratoid/rhabdoid tumors (AT/RT) are highly aggressive malignant primitive neoplasms that commonly occur in children younger than 2 years of age. The prognosis is generally dismal with a median survival time of <1 year. The majority of AT/RT occur in the posterior fossa and less frequently the supratentorium. Primary pediatric spinal AT/RT are exceedingly rare and only 15 cases have been reported to date. Here we report a very unusual case of primary spinal AT/RT extensively involving the spinal cord from T11 down to the cauda equina...
January 16, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29344232/novel-combination-of-paraspinal-keyhole-surgery-with-a-tubular-retractor-system-leads-to-significant-improvements-in-lumbar-intraspinal-extramedullary-schwannomas
#4
Yuandong Zhuang, Gangfeng Cai, Chaofeng Fu, Weiqiang Zhang, Wei Zhao, Rui Wang, Chunhua Wang, Songsheng Shi, Chunmei Chen
The aim of the present study was to investigate the efficacy of combining paraspinal keyhole surgery with a tubular retractor system for the microsurgical removal of lumbar intraspinal extramedullary schwannomas. A retrospective analysis was conducted of 56 patients with lumbar intraspinal extramedullary schwannomas who were treated using the microsurgical paraspinal keyhole approach with a tubular retractor system. The mean ± standard deviation was calculated for the following parameters: Surgery time (96...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29336922/segmentation-free-direct-tumor-volume-and-metabolic-activity-estimation-from-pet-scans
#5
Saeid Asgari Taghanaki, Noirin Duggan, Hillgan Ma, Xinchi Hou, Anna Celler, Francois Benard, Ghassan Hamarneh
Tumor volume and metabolic activity are two robust imaging biomarkers for predicting early therapy response in F-fluorodeoxyglucose (FDG) positron emission tomography (PET), which is a modality to image the distribution of radiotracers and thereby observe functional processes in the body. To date, estimation of these two biomarkers requires a lesion segmentation step. While the segmentation methods requiring extensive user interaction have obvious limitations in terms of time and reproducibility, automatically estimating activity from segmentation, which involves integrating intensity values over the volume is also suboptimal, since PET is an inherently noisy modality...
December 27, 2017: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/29329586/il-33-st2-signaling-contributes-to-radicular-pain-by-modulating-mapk-and-nf-%C3%AE%C2%BAb-activation-and-inflammatory-mediator-expression-in-the-spinal-cord-in-rat-models-of-noncompressive-lumber-disk-herniation
#6
Si-Jian Huang, Jian-Qin Yan, Hui Luo, Lu-Yao Zhou, Jian-Gang Luo
BACKGROUND: Immune and inflammatory responses occurring in the spinal cord play a pivotal role in the progression of radicular pain caused by intervertebral disk herniation. Interleukin-33 (IL-33) orchestrates inflammatory responses in a wide range of inflammatory and autoimmune disorders of the nervous system. Thus, the purpose of this study is to investigate the expression of IL-33 and its receptor ST2 in the dorsal spinal cord and to elucidate whether the inhibition of spinal IL-33 expression significantly attenuates pain-related behaviors in rat models of noncompressive lumbar disc herniation...
January 12, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29314220/histopathology-of-synovial-cysts-of-the-spine
#7
Ivan Chebib, Connie Y Chang, Joseph H Schwab, Darcy A Kerr, Vikram Deshpande, G Petur Nielsen
AIMS: Cystic lesions derived from the synovial and ligamentous structures of the spine have varied histologic appearances. Not uncommonly, there is discrepancy between the clinico-radiologic diagnosis and histology. Therefore, we sought to characterize the histologic features of tissue submitted as "synovial cysts" of the spine. METHODS: Resected specimens of the spine labeled "synovial cysts" and "lumbar cysts" were histologically evaluated and classified based on histopathologic features...
January 4, 2018: Histopathology
https://www.readbyqxmd.com/read/29313091/intradural-cervical-chordoma-with-diffuse-spinal-leptomeningeal-spread-case-report-and-review-of-the-literature
#8
Jing Zhang, Chuan-Ping Gao, Xue-Jun Liu, Wen-Jian Xu
PURPOSE: Chordoma is a low-grade malignant bone tumor derived from embryonic notochord remnants along the axial skeleton. About 50% of chordomas occur in the sacral vertebrae and 35% in the skull base. Most chordomas are extradural and cause extensive bone destruction. Intradural spinal tumors without bone involvement are rare. METHODS: We herein describe the clinical features of a patient with a chordoma as well as the imaging and pathological manifestations of the tumor...
January 8, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29312473/central-nervous-system-gadolinium-accumulation-in-patients-undergoing-periodical-contrast-mri-screening-for-hereditary-tumor-syndromes
#9
Evelynn Vergauwen, Anne-Marie Vanbinst, Carola Brussaard, Peter Janssens, Dieter De Clerck, Michel Van Lint, Anne C Houtman, Olaf Michel, Kathelijn Keymolen, Bieke Lefevere, Susanne Bohler, Dirk Michielsen, Anna C Jansen, Vera Van Velthoven, Sven Gläsker
Background: Patients with hereditary tumor syndromes undergo periodical magnetic resonance imaging (MRI) screening with Gadolinium contrast. Gadolinium accumulation has recently been described in the central nervous system after repeated administrations. The prevalence and rate of accumulation in different subgroups of patients are unknown. Neither are the mechanism nor clinical impact. This may cause uncertainty about the screening. To explore the prevalence and rate of Gadolinium accumulation in different subgroups, we retrospectively analyzed MRIs of patients with von Hippel-Lindau disease (VHL) and Tuberous Sclerosis Complex (TSC)...
2018: Hereditary Cancer in Clinical Practice
https://www.readbyqxmd.com/read/29303468/validation-of-patient-reported-outcomes-measurement-information-system-promis-computerized-adaptive-tests-in-cervical-spine-surgery
#10
Barrett S Boody, Surabhi Bhatt, Aditya S Mazmudar, Wellington K Hsu, Nan E Rothrock, Alpesh A Patel
OBJECTIVE The Patient-Reported Outcomes Measurement Information System (PROMIS), which is funded by the National Institutes of Health, is a set of adaptive, responsive assessment tools that measures patient-reported health status. PROMIS measures have not been validated for surgical patients with cervical spine disorders. The objective of this project is to evaluate the validity (e.g., convergent validity, known-groups validity, responsiveness to change) of PROMIS computer adaptive tests (CATs) for pain behavior, pain interference, and physical function in patients undergoing cervical spine surgery...
January 5, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29301179/glomangiopericytoma-of-the-spinal-cord
#11
Sung Shik Kang, Hee Seok Jeong, Hee Young Son, Tae Yong Moon
Glomangiopericytoma, also referred to as a hemangiopericytoma-like tumor or sinonasal type hemangiopericytoma, is a rare tumor of the nasal cavity and paranasal sinus that has never been reported in the spinal cord. Here, we report a case of a 47-year-old man who developed glomangiopericytoma in the thoracic spine. This lesion showed a heterogeneous high signal intensity compared to the spinal cord on a T2-weighted image and an easily enhanced isointense signal on a T1-weighted image.
December 2017: Korean Journal of Spine
https://www.readbyqxmd.com/read/29296040/evaluation-and-performance-of-arccheck-and-film-using-gamma-criteria-in-pre-treatment-quality-assurance-of-stereotactic-ablative-radiotherapy
#12
Prabhakar Ramachandran, Abdulrahman Tajaldeen, David Taylor, Derrick Wanigaratne, Karl Roozen, Moshi Geso
Aim: The aim of this study is to assess the use of ArcCHECK (AC) as an alternative method to replace film dosimetry for pre-treatment quality assurance (QA) of three-dimensional conformal radiation therapy, intensity-modulated radiation therapy (IMRT), and volumetric-modulated arc therapy (VMAT) stereotactic ablative radiotherapy (SABR) treatment plans. Materials and Methods: Twenty-five patients with a varied diagnosis of lung, spine, sacrum, sternum, ribs, scapula, and femur undergoing SABR were selected for this study...
October 2017: Journal of Medical Physics
https://www.readbyqxmd.com/read/29290904/primary-extradural-paraganglioma-of-the-thoracic-spine-a-case-report
#13
Alexander Reddy, Fanny Morón
Paragangliomas are rare, mostly benign neuroendocrine tumors arising from autonomic paraganglia. Spinal paragangliomas are uncommon, and among these, paragangliomas of the thoracic spine are distinctly unusual. We present the case of a primary paraganglioma of the extradural thoracic spine in a 34-year-old woman.
December 2017: Journal of Radiology Case Reports
https://www.readbyqxmd.com/read/29289918/intraoperative-neurophysiological-monitoring-during-the-surgery-of-spinal-arteriovenous-malformation-sensitivity-specificity-and-warning-criteria
#14
Xiaoyu Li, Hong-Qi Zhang, Feng Ling, Chuan He, Peng Hu, Tao Hu, Jiaxing Yu
OBJECTIVE: The incidence of spinal arteriovenous malformation (SAVM) is low, but its treatment is challenging. Intraoperative neurophysiological monitoring (IONM) for intramedullary tumors has been a benchmark in neurosurgery. This study aimed to determine the sensitivity, specificity, and warning criteria of IONM for SAVM surgeries. MATERIALS AND METHODS: From November 2012 to January 2016, 55 patients underwent SAVM surgery with IONM at the Neurosurgery Department of Xuanwu Hospital of Capital Medical University, China...
December 21, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29287117/metastatic-spinal-cord-compression-mscc-treated-with-palliative-decompression-surgical-timing-and-survival-rate
#15
Wan-Yu Lo, Shu-Hua Yang
BACKGROUND: Metastatic spinal cord compression (MSCC) treatment depends on life expectancies. Data regarding palliative decompression outcomes is scarce. We demonstrate that surgical timing has a significant impact on survival in MSCC patients treated with palliative decompression. METHODS: Eighty-nine consecutive MSCC patients at a tertiary referral medical center were enrolled between January 2012 and February 2016. Wide laminectomy was performed for tumors invading the vertebral body...
2017: PloS One
https://www.readbyqxmd.com/read/29286966/isolated-scapular-metastasis-in-a-patient-with-malignant-struma-ovarii-a-case-report
#16
Juliane Comunello, Fábio Fernando Eloi Pinto, Suely Akiko Nakagawa, Wu Tu Chung, Felipe D'Almeida Costa, Américo Delgado Brilhante
CASE: We report the case of a 38-year-old woman who presented with a lytic bone lesion in the left scapula. A biopsy showed a tumor with the histologic appearance of thyroid tissue. She also was found to have a thyroid nodule and an enlarged ovary, both of which were excised. The thyroid nodule turned out to be a benign colloid nodule, and the ovary contained a monodermal teratoma composed of thyroid tissue (struma ovarii). The lesion in the scapula eventually was proven to be metastatic malignant struma ovarii...
October 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29284846/comparison-of-the-intravenous-and-epidural-administration-of-tumor-necrosis-factor-alpha-antagonists-in-an-experimental-rat-pain-model
#17
Serbülent Gökhan Beyaz, Mustafa Erkan İnanmaz, Tolga Ergönenç, Onur Palabıyık, Yakup Tomak, Ayça Taş Tuna
Introduction: Inflammatory cytokines secreted from the nucleus pulposus are thought to lead to lumbar nerve root compression-like symptoms. Tumor necrosis factor-alpha (TNF-α), an inflammatory cytokine, likely plays an important role in lumbar disc hernia-related leg pain. In this experimental study, we compared the effectiveness of TNF-α antagonists administered through the intravenous or epidural route in lumbar spine pathologies. Materials and Methods: After ethics committee approval had been obtained, 24 Sprague Dawley male rats aged 70-90 days and weighing 250-300 g each were allocated to four groups...
October 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29284779/adsorption-rheological-properties-of-blood-serum-in-lung-cancer-patients
#18
Y V Dumanskiy, O Y Stoliarova, O V Syniachenko, M F Giulmamedova, Y A Potapov
The aim and objectives of the study were to investigate the state of adsorption-rheological properties of blood (ARPB) in patients with different clinical course of lung cancer (LC), the detection of violations of surface-active, viscoelastic and relaxation properties of blood serum, their association with tumor markers, the evaluation of the prognostic value of initial indexes in the development of complications from radiochemotherapy. PATIENTS AND METHODS: The study included 115 patients with LC at the age from 24 to 80 years (average age 58 years), among whom there were 78% men and 22% women...
December 2017: Experimental Oncology
https://www.readbyqxmd.com/read/29281479/abscopal-effect-of-radiation-on-bone-metastases-of-breast-cancer-a-case-report
#19
Henry Wc Leung, Shyh-Yau Wang, Huang Jin-Jhih, Agnes Lf Chan
The abscopal effect is defined as the clearance of distant tumors after applying localized irradiation to a particular tumor site. It has been proposed that a mechanism for the abscopal effect might be the activation of the immune system, which leads to immunogenic tumor cell death. Here, we describe a woman with advanced breast cancer that received modified ablative radiation therapy that targeted her primary breast tumor. She experienced an apparent regression of metastatic mass in the thoracic spine. This case supported the hypothesis that the abscopal effect might be attributable to an activation of the systemic immune response...
December 27, 2017: Cancer Biology & Therapy
https://www.readbyqxmd.com/read/29280455/a-detailed-dosimetric-analysis-of-spinal-cord-tolerance-in-high-dose-spine-radiosurgery
#20
Evangelia Katsoulakis, Andrew Jackson, Brett Cox, Michael Lovelock, Yoshiya Yamada
OBJECTIVE: Dose-volume tolerance of the spinal cord (SC) in spinal stereotactic radiosurgery (SRS) is difficult to define because radiation myelitis rates are low, and published reports document cases of myelopathy but do not account for the total number of patients treated at given dose-volume combinations who do not have myelitis. This study reports SC toxicity from single-fraction spinal SRS and presents a comprehensive atlas of the incidence of adverse events to examine dose-volume predictors...
November 1, 2017: International Journal of Radiation Oncology, Biology, Physics
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