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Vitamin D immunology

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https://www.readbyqxmd.com/read/27833053/western-diet-enhances-intestinal-tumorigenesis-in-min-mice-associating-with-mucosal-metabolic-and-inflammatory-stress-and-loss-of-apc-heterozygosity
#1
Mikael Niku, Anne-Maria Pajari, Laura Sarantaus, Essi Päivärinta, Markus Storvik, Anu Heiman-Lindh, Santeri Suokas, Minna Nyström, Marja Mutanen
Western-type diet (WD) is a risk factor for colorectal cancer, but the underlying mechanisms are poorly understood. We investigated the interaction of WD and heterozygous mutation in the Apc gene on adenoma formation and metabolic and immunological changes in the histologically normal intestinal mucosa of Apc(Min/+) (Min/+) mice. The diet used was high in saturated fat and low in calcium, vitamin D, fiber and folate. The number of adenomas was twofold higher in the WD mice compared to controls, but adenoma size, proliferation or apoptosis did not differ...
January 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27827293/vitamin-d-deficiency-behavioral-atypicality-anxiety-and-depression-in-children-with-chromosome-22q11-2-deletion-syndrome
#2
L Kelley, A F P Sanders, E A Beaton
Chromosome 22q11.2 deletion syndrome (22q11.2DS) is a complex developmental disorder with serious medical, cognitive and emotional symptoms across the lifespan. This genetic deletion also imparts a lifetime risk for developing schizophrenia that is 25-30 times that of the general population. The origin of this risk is multifactorial and may include dysregulation of the stress response and immunological systems in relation to brain development. Vitamin D is involved in brain development and neuroprotection, gene transcription, immunological regulation and influences neuronal signal transduction...
December 2016: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/27816874/prevailing-vitamin-d-status-influences-mitochondrial-and-glycolytic-bioenergetics-in-peripheral-blood-mononuclear-cells-obtained-from-adults
#3
Emily K Calton, Kevin N Keane, Mario J Soares, Jordan Rowlands, Philip Newsholme
BACKGROUND: Circulating peripheral blood mononuclear cells (PBMCs) are exposed to metabolic and immunological stimuli that influence their functionality. We hypothesized that prevailing vitamin D status [25(OH)D] would modulate the bioenergetic profile of PBMCs derived from humans. MATERIALS AND METHODS: 38 participants (16 males, 22 females) ranging in body fat from 14-51% were studied. PBMCs were isolated from whole blood, counted and freshly seeded for bioenergetic analysis using the Seahorse XF(e)96 flux analyser...
December 2016: Redox Biology
https://www.readbyqxmd.com/read/27793368/loss-of-placental-thrombomodulin-in-oocyte-donation-pregnancies
#4
Manon Bos, Hans J Baelde, Jan A Bruijn, Kitty W M Bloemenkamp, Marie-Louise P van der Hoorn, Rosanne J Turner
OBJECTIVE: To investigate whether thrombomodulin dysregulation is involved in the development of preeclampsia after oocyte donation (OD). Women who become pregnant after OD are prone to develop preeclampsia, a syndrome characterized by an aberrant immunologic response, hypercoagulability, and endothelial dysfunction. A mediator of inflammation and coagulation is thrombomodulin, which has a possible role to play in this syndrome. DESIGN: Case-control study. SETTING: Not applicable...
October 25, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27786545/vitamin-d-levels-in-children-affected-by-vernal-keratoconjuctivitis
#5
Anna Maria Zicari, Arianna Cafarotti, Francesca Occasi, Valeria Lollobrigida, Marcella Nebbioso, Irene Pecorella, Giovanna De Castro, Alberto Spalice, Lorenzo Loffredo, Maria Pia Villa, Marzia Duse
BACKGROUND: Vernal keratoconjunctivitis (VKC) is a chronic and often severe bilateral conjunctivitis. VKC etiology remains still unclear although endocrine, genetic, neurogenic and environmental factors have been implied. Vitamin D is a fat-soluble prohormone whose main function is the regulation of calcium and phosphate metabolism. The aim of this study was to evaluate serum vitamin D in children affected by VKC compared to the healthy children and investigate the relationship between its levels and disease severity...
October 27, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27775585/beneficial-effects-of-uv-radiation-vitamin-d-and-beyond
#6
Christian Trummer, Marlene Pandis, Nicolas Verheyen, Martin R Grübler, Martin Gaksch, Barbara Obermayer-Pietsch, Andreas Tomaschitz, Thomas R Pieber, Stefan Pilz, Verena Schwetz
Aside from its well-known effects on bone and mineral metabolism, vitamin D may also play an important role in extra-skeletal processes like immunologic diseases, cancer, or cardiovascular diseases. Even though meta-analyses showed that vitamin D supplementation reduces fractures, falls, and overall mortality, its potential benefits did not find universal acclaim. Several health care authorities published Recommended Dietary Allowances (RDAs) for vitamin D, most of them ranging from 600 to 800 international units (IU) per day, corresponding to a serum level of 25-hydroxyvitamin D of at least 20 ng/mL (50 nmol/L)...
October 19, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27766084/vitamin-d-deficiency-in-adult-patients-with-schizophreniform-and-autism-spectrum-syndromes-a-one-year-cohort-study-at-a-german-tertiary-care-hospital
#7
Dominique Endres, Rick Dersch, Oliver Stich, Armin Buchwald, Evgeniy Perlov, Bernd Feige, Simon Maier, Andreas Riedel, Ludger Tebartz van Elst
INTRODUCTION: Vitamin D has many immunomodulatory, anti-inflammatory, and neuroprotective functions, and previous studies have demonstrated an association between vitamin D deficiency and neuropsychiatric disease. The aim of our study was to analyze the prevalence of vitamin D deficiency in a 1-year cohort of adult inpatients with schizophreniform and autism spectrum syndromes in a naturalistic inpatient setting in Germany. PARTICIPANTS AND METHODS: Our study was comprised of 60 adult schizophreniform and 23 adult high-functioning autism spectrum patients who were hospitalized between January and December of 2015...
2016: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/27726023/regioselective-hydroxylation-of-cholecalciferol-cholesterol-and-other-sterol-derivatives-by-steroid-c25-dehydrogenase
#8
A Rugor, M Tataruch, J Staroń, A Dudzik, E Niedzialkowska, P Nowak, A Hogendorf, A Michalik-Zym, D B Napruszewska, A Jarzębski, K Szymańska, W Białas, M Szaleniec
Steroid C25 dehydrogenase (S25DH) from Sterolibacterium denitrificans Chol-1S is a molybdenum oxidoreductase belonging to the so-called ethylbenzene dehydrogenase (EBDH)-like subclass of DMSO reductases capable of the regioselective hydroxylation of cholesterol or cholecalciferol to 25-hydroxy products. Both products are important biologically active molecules: 25-hydroxycholesterol is responsible for a complex regulatory function in the immunological system, while 25-hydroxycholecalciferol (calcifediol) is the activated form of vitamin D3 used in the treatment of rickets and other calcium disorders...
October 11, 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27717877/1-25-dihydroxyvitamin-d3-down-modulates-the-production-of-proinflammatory-cytokines-and-nitric-oxide-and-enhances-the-phosphorylation-of-monocyte-expressed-stat6-at-the-recent-onset-type-1-diabetes
#9
Lamia Ysmail-Dahlouk, Wafa Nouari, Mourad Aribi
BACKGROUND: Type 1 diabetes (T1D) is associated with an imbalance between inflammation and repair. Recently, the biologically active form of vitamin D3, i.e. 1,25(OH)2D3, has been reported to have potent immunomodulatory effects on both innate and adaptive immune cells, as well as on the production of their specific cytokines. METHODS: We examined the effect of 1,25(OH)2D3 on the production of proinflammatory Th1/Th17 and anti-inflammatory Th2/Treg related cytokines, as well as on the phosphorylation of monocyte-expressed STAT4 and STAT6 at the recent-onset human T1D...
October 4, 2016: Immunology Letters
https://www.readbyqxmd.com/read/27708971/low-vitamin-d-status-in-systemic-sclerosis-and-the-impact-on-disease-phenotype
#10
Laura Groseanu, Violeta Bojinca, Tania Gudu, Ioana Saulescu, Denisa Predeteanu, Andra Balanescu, Florian Berghea, Daniela Opris, Andreea Borangiu, Cosmin Constantinescu, Magda Negru, Ruxandra Ionescu
OBJECTIVE: Vitamin D has pleiotropic effects including immunomodulatory, cardioprotective, and antifibrotic properties and is thus able to modulate the three main links in scleroderma pathogenesis. The aim of the study was to evaluate the level of vitamin D in patients with systemic sclerosis and to analyze the associations between the concentration of vitamin D and the features of systemic sclerosis. MATERIAL AND METHODS: Fifty-one consecutive patients were evaluated for visceral involvement, immunological profile, activity, severity scores, and quality of life...
June 2016: Eur J Rheumatol
https://www.readbyqxmd.com/read/27695278/vitamin-d-deficiency-in-egyptian-systemic-lupus-erythematosus-patients-how-prevalent-and-does-it-impact-disease-activity
#11
Nouran M Abaza, Reem M El-Mallah, Asmaa Shaaban, Sameh A Mobasher, Khaled F Al-Hassanein, Amr A Abdel Zaher, Rania H El-Kabarity
BACKGROUND: The emerging role of vitamin D in immunology and autoimmune disorders has been a worldwide interest in the last decade. Systemic lupus erythematosus (SLE) patients are particularly at a delicate position predisposing them to suffer from vitamin D deficiency due to the multiple risk factors accompanying the disease. Whether vitamin D deficiency is also involved as a risk factor for developing SLE and affecting its course is a considerable concern. OBJECTIVES: The objective of this study was to estimate the prevalence of vitamin D deficiency in SLE patients and its relation to disease...
2016: Integrative Medicine Insights
https://www.readbyqxmd.com/read/27647308/a-novel-combination-of-docosahexaenoic-acid-all-trans-retinoic-acid-and-1-25-dihydroxyvitamin-d3-reduces-t-bet-gene-expression-serum-interferon-gamma-and-clinical-scores-but-promotes-ppar%C3%AE-gene-expression-in-experimental-autoimmune-encephalomyelitis
#12
Mohammad Reza Shiri-Shahsavar, Abbas Mirshafiee, Karim Parastouei, Abbas Ebrahimi-Kalan, Saeed Yekaninejad, Farid Soleymani, Reza Chahardoli, Ramin Mazaheri Nezhad Fard, Ali Akbar Saboor-Yaraghi
Vitamins are immunologically interesting due to their significant immunomodulatory activities. Experimental autoimmune encephalomyelitis (EAE) is one of the most commonly used experimental models for studying autoimmune disorder in multiple sclerosis (MS). The aim of this study was to evaluate the protective and ameliorative effects of novel combination of all-trans retinoic acid (ATRA), 1,25-dihydroxyvitamin D3 (D3), and docosahexaenoic acid (DHA) on EAE-specific determinants and target gene expressions. Mice were randomly categorized into three groups before EAE induction [non-treated EAE (Group E), treated EAE (Group T), and healthy mice (Group H)]...
September 19, 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/27620138/vitamin-d-treatment-attenuates-2-4-6-trinitrobenzene-sulphonic-acid-tnbs-induced-colitis-but-not-oxazolone-induced-colitis
#13
Tianjing Liu, Yongyan Shi, Jie Du, Xin Ge, Xu Teng, Lu Liu, Enbo Wang, Qun Zhao
Crohn's disease (CD) and ulcerative colitis (UC) have different immunological mechanisms, while both of them are potential targets of vitamin D treatment. In this study, we have tried to address the role of vitamin D in CD and UC using two mouse models. Mice of C57B6L were given vitamin D before the induction of colitis. Our results showed that vitamin D attenuated 2,4,6-trinitrobenzene sulphonic acid (TNBS)-induced colitis but not oxazolone-induced colitis. Vitamin D could preserve the local histology, alleviate inflammation, suppress apoptosis, maintain tight junction function and decrease permeability...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27608289/cell-type-specific-modulation-of-innate-immune-signalling-by-vitamin-d-in-human-mononuclear-phagocytes
#14
Rhiannon Kundu, Aikaterini Theodoraki, Carolin T Haas, Yanjing Zhang, Benjamin Chain, Janos Kriston-Vizi, Mahdad Noursadeghi, Bernard Khoo
Vitamin D is widely reported to inhibit innate immune signalling and dendritic cell (DC) maturation as a potential immunoregulatory mechanism. It is not known whether vitamin D has global or gene-specific effects on transcriptional responses downstream of innate immune stimulation, or whether vitamin D inhibition of innate immune signalling is common to different cells. We confirmed vitamin D inhibition of nuclear factor-κB (NF-κB) and p38 mitogen-activated protein kinase (MAPK) signalling in monocyte-derived DC (MDDC) stimulated with lipopolysaccharide (LPS)...
January 2017: Immunology
https://www.readbyqxmd.com/read/27595605/vitamin-d-receptor-gene-associations-with-pulmonary-tuberculosis-in-a-tibetan-chinese-population
#15
Qunying Hu, Zhengshuai Chen, Guinian Liang, Fangping Mo, Hengxun Zhang, Shilin Xu, Yuhe Wang, Longli Kang, Tianbo Jin
BACKGROUND: The vitamin D receptor (VDR) mediates the immunological function of vitamin D3, which activates macrophages, and vitamin D deficiency has been linked to tuberculosis risk. Single nucleotide polymorphisms (SNPs) in VDR may influence the function of vitamin D and susceptibility to tuberculosis. METHODS: This study included 217 patients with pulmonary tuberculosis (PTB) and 383 healthy subjects in a Tibetan Chinese population living in and near Xi'an. Association analyses of SNPs in VDR were performed with the SPSS 17...
2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27533066/serum-25-hydroxyvitamin-d-in-early-childhood-is-nonlinearly-associated-with-allergy
#16
Emma Merike Savilahti, Outi Mäkitie, Anna Kaarina Kukkonen, Sture Andersson, Heli Viljakainen, Erkki Savilahti, Mikael Kuitunen
BACKGROUND: Vitamin D has several immunological functions. Data on the relation of vitamin D status and allergy are controversial. METHODS: We investigated the association between serum concentrations of 25-hydroxyvitamin D (25-OHD) and allergy in childhood. The study population (n = 819) was part of a randomized, double-blind, placebo-controlled trial where the mothers of offspring with a high risk for allergy received a mixture of probiotics (or placebo) for the last 4 weeks of pregnancy, and the child received this from birth to 6 months...
2016: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/27520300/human-cytomegalovirus-infection-downregulates-vitamin-d-receptor-in-mammalian-cells
#17
Franz J J Rieder, Charlotte Gröschel, Marie-Theres Kastner, Karin Kosulin, Johannes Laengle, Rene Zadnikar, Rodrig Marculescu, Martina Schneider, Thomas Lion, Michael Bergmann, Enikö Kallay, Christoph Steininger
Vitamin D (VD) is essential for the human body and involved in a wide variety of critical physiological processes including bone, muscle, and cardiovascular health, as well as innate immunity and antimicrobial responses. Here, we elucidated the significance of the VD system in cytomegalovirus (CMV) infection, which is one of the most common opportunistic infections in immunocompromised or -suppressed patients. We found that expression of vitamin D receptor (VDR) was downregulated in CMV-infected cells within 12h [hrs] post infection [p...
January 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27493451/inflammation-thread-runs-across-medical-laboratory-specialities
#18
REVIEW
Urs Nydegger, Thomas Lung, Lorenz Risch, Martin Risch, Pedro Medina Escobar, Thomas Bodmer
We work on the assumption that four major specialities or sectors of medical laboratory assays, comprising clinical chemistry, haematology, immunology, and microbiology, embraced by genome sequencing techniques, are routinely in use. Medical laboratory markers for inflammation serve as model: they are allotted to most fields of medical lab assays including genomics. Incessant coding of assays aligns each of them in the long lists of big data. As exemplified with the complement gene family, containing C2, C3, C8A, C8B, CFH, CFI, and ITGB2, heritability patterns/risk factors associated with diseases with genetic glitch of complement components are unfolding...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27484676/klokwerk%C3%A2-%C3%A2-study-protocol-an-observational-study-to-the-effects-of-night-shift-work-on-body-weight-and-infection-susceptibility-and-the-mechanisms-underlying-these-health-effects
#19
Bette Loef, Debbie van Baarle, Allard J van der Beek, Linda W van Kerkhof, Daniëlla van de Langenberg, Karin I Proper
BACKGROUND: Night-shift work may cause severe disturbances in the worker's circadian rhythm, which has been associated with the onset of health problems and diseases. As a substantial part of the workforce is exposed to night-shift work, harmful aspects of night-shift work should not be overlooked. The aim of the Klokwerk + study is to study the effects of night-shift work on body weight and infection susceptibility and the mechanisms underlying these health effects. First, we will study the relation between night-shift work exposure and body weight and between night-shift work exposure and infection susceptibility...
2016: BMC Public Health
https://www.readbyqxmd.com/read/27477034/the-relationship-between-serum-levels-of-vitamin-d-with-asthma-and-its-symptom-severity-a-case-control-study
#20
Rasoul Nasiri Kalmarzi, A Zamani, A Fathallahpour, E Ghaderi, Ramesh Rahehagh, W Kooti
BACKGROUND: Asthma is a heterogeneous disease characterised by chronic inflammatory airways, and is affected by several immunological factors. One of the most discussed and researched hypotheses is the relationship between vitamin D serum levels with asthma. This study aimed to investigate the relationship between vitamin D serum levels with asthma and pulmonary functions in children in Kurdistan province, Iran. MATERIALS AND METHODS: In this case-control study, 120 children ranging from 6 to 18 years were referred in summer for investigation...
July 28, 2016: Allergologia et Immunopathologia
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