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Vitamin D infections

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https://www.readbyqxmd.com/read/29766504/indene-compounds-synthetically-derived-from-vitamin-d-have-selective-antibacterial-action-on-helicobacter-pylori
#1
Kiyofumi Wanibuchi, Kouichi Hosoda, Masato Ihara, Kentaro Tajiri, Yuki Sakai, Hisashi Masui, Takashi Takahashi, Yoshikazu Hirai, Hirofumi Shimomura
Helicobacter pylori infects the human stomach and is closely linked with the development of gastric cancer. When detected, this pathogen can be eradicated from the human stomach using wide-spectrum antibiotics. However, year by year, H. pylori strains resistant to the antibacterial action of antibiotics have been increasing. The development of new antibacterial substances effective against drug-resistant H. pylori is urgently required. Our group has recently identified extremely selective bactericidal effects against H...
May 16, 2018: Lipids
https://www.readbyqxmd.com/read/29766002/influence-of-vitamin-d-receptor-gene-polymorphisms-on-response-to-pegylated-interferon-in-chronic-hepatitis-b-egyptian-patients
#2
Gomaa Mostafa-Hedeab, Dina Sabry, Ghada Mostafa Abdelaziz, Manal Ewaiss, Nagla Adli, Wael Fathy
Background: We explored the effect of vitamin D receptor gene ( VDR ) polymorphisms in response to PEG-IFN treatment in Egyptian chronic hepatitis B (CHB) patients. Methods: Two hundred hepatitis B virus (HBV) patients (42.3±10.7 years) on PEG-IFN α-2a (180 µg /kg for 48 weeks) and one hundred control subjects (37.3 ±12 years) were enrolled in the study. Vitamin D levels and hepatitis B surface antigen (HBsAg) expression were assessed by ELISA. VDR polymorphisms FokI T>C (rs 10735810), BsmI A>G (rs 1544410), ApaI (rs7975253), and TaqI C>T (rs 731236), were genotyped using real-time PCR...
April 2018: Reports of Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29765171/risks-and-protective-factors-for-triple-negative-breast-cancer-with-a-focus-on-micronutrients-and-infections
#3
Dagmar Horakova, Katerina Bouchalova, Karel Cwiertka, Ladislav Stepanek, Jana Vlckova, Helena Kollarova
Triple negative breast cancer (TNBC) is an aggressive form of breast cancer (BC) with a poor prognosis. Second, patients cannot benefit from targeted therapy, except for those with BRCA1/2 mutations, for whom poly (ADP-ribose) polymerase (PARP) inhibition therapy using olaparib has recently been approved. As global priorities continue to be epidemiological analysis of BC risk factors and early diagnosis, this review focuses on the risks and protective factors associated with TNBC. A PubMed keyword search for new knowledge on the risks and protective factors for TNBC was carried out...
May 15, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29763933/the-calcium-sensing-receptor-gene-polymorphism-rs1801725-and-calcium-related-phenotypes-in-hemodialysis-patients
#4
Alicja E Grzegorzewska, Dariusz Bednarski, Monika Świderska, Adrianna Mostowska, Paweł P Jagodziński
BACKGROUND/AIMS: The calcium-sensing receptor gene (CASR) rs1801725 variant is responsible for a non-conservative amino-acid change (A986S) in the calcium-sensing receptor cytoplasmic tail. We hypothesized that rs1801725 polymorphism might be helpful in understanding Ca-related abnormalities in HD patients. METHODS: In 1215 subjects (245 on cinacalcet), we determined the associations of rs1801725 with secondary hyperparathyroidism (sHPT)-related laboratory parameters, PTH-decreasing effect of cinacalcet hydrochloride, coronary artery disease (CAD), myocardial infarction (MI), nephrolithiasis-related ESRD, and mortality...
May 10, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29759135/the-levels-of-soluble-forms-of-cd21-and-cd83-in-multiple-sclerosis
#5
Sajad Karampoor, Hamid Zahednasab, Masoud Etemadifar, Hossein Keyvani
Multiple Sclerosis (MS) is a neuroinflammatory disease of the central nervous system (CNS) in which immune system plays a crucial role in progression of the disease. An enormous amount of research has been shown that immune mediators such as cytokines and chemokines are the culprits of MS propagation suggesting that modulation of such molecules may pave the path to hinder the disease development. It has been shown that both CD21 and CD83 contribute to the resolution of inflammation occurred in MS. CD21 and CD83 have also been ascribed to Epstein Barr virus (EBV) infection (the prime suspect of MS causality) and the levels of vitamin D, respectively...
July 15, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29754190/allergic-and-immunologic-perspectives-of-inflammatory-bowel-disease
#6
REVIEW
Kofi Clarke, Jayakrishna Chintanaboina
Inflammatory bowel disease (IBD) is a chronic immune-mediated inflammatory condition primarily involving the gastrointestinal tract. It includes Crohn's disease (CD), ulcerative colitis (UC), and a less common phenotype-indeterminate colitis. It is thought to result from a complex interplay of environmental, microbial, and host factors including genetic factors, although the exact mechanism is not known. Dietary factors have been shown to play a role in the pathogenesis of IBD and can potentially alter the intestinal microbiota as well as disrupt the immune function in the gut...
May 12, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29747301/-the-463rd-case-rhabdomyolysis-acute-kidney-failure-and-acute-hepatic-failure
#7
W Shi, D Wu, N Si, W Jiang, J Ma, X M Li
We represented a 22-year-old male patient who developed rhabdomyolysis, acute kidney failure and acute hepatic failure and was finally diagnosed as multiple acyl-CoA dehydrogenase deficiency. The patient appeared temporary stable status after high dose vitamine-B(2) supplement whereas deterioration was still fatal with pulmonary infection, acute respiratory failure and acute heart failure.
May 1, 2018: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29745286/therapeutic-and-immune-function-improvement-of-vitamin-d-combined-with-ifn-%C3%AE-on-mouse-with-hepatitis-b-infection
#8
Yonghui Bi, Weiguo Zhang, Jian Sun, Ruohui Gao
This study aims to investigate the therapeutic effect of vitamin D (VD) combined with interferon (IFN) type I (IFN-α) on mice with hepatitis B and to explore the possible mechanism. The mice were divided into control group, model group, IFN-α group, and IFN-α +  VD group. After 4 weeks, the mice of four groups were weighed, and the thymus and spleen indexes were calculated. The activity of alanine transaminase (ALT) and aspartate transaminase (AST) in the serum was detected while pathological changes of the liver were observed...
January 2018: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/29739378/higher-serum-25-hydroxyvitamin-d-concentrations-are-associated-with-active-pulmonary-tuberculosis-in-hospitalised-hiv-infected-patients-in-a-low-income-tropical-setting-a-cross-sectional-study
#9
Cuthbert Musarurwa, Lynn Sodai Zijenah, Doreen Zvipo Mhandire, Tsitsi Bandason, Kudakwashe Mhandire, Maria Mary Chipiti, Marshall Wesley Munjoma, Witmore Bayayi Mujaji
BACKGROUND: The inherent risk of developing tuberculosis (TB) in HIV- infected individuals is further enhanced by hypovitaminosis D. Interventions that offset HIV-associated immune deterioration potentially arrest disease progression and incidence of opportunistic infections including TB. Despite conflicting reports on association between vitamin D deficiency (VDD) and risk of TB, vitamin D (VD) supplementation remains a promising intervention. METHODS: We conducted a comparative cross-sectional study on 145 HIV+ /pulmonary TB+ (PTB) and 139 HIV+ /PTB- hospitalised patients to investigate association of vitamin D status and risk of PTB...
May 8, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29739069/association-between-vitamin-d-status-and-sepsis
#10
Wei Zhou, Song Mao, Liangxia Wu, Jun Yu
BACKGROUND: It is well-established that vitamin D status is closely associated with the susceptibility to infections. We aimed to study the association between vitamin D status and sepsis risk and death, and also analyzed the correlation between vitamin D level and sepsis-related factors. METHODS: We searched the articles regarding the association between vitamin D level and sepsis through May 2017 in electronic databases. We pooled the data and analyzed the association between vitamin D level and sepsis risk, death, and albumin (ALB), mortality, body mass index (BMI), procalcitonin (PCT), male/female ratio, interleukin-6 (IL-6), platelet (PLT), c-reactive protein (CRP) and white blood cell (WBC)...
April 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29736706/nutrient-stress-small-molecule-screening-platform-for-escherichia-coli
#11
Sara S El Zahed, Garima Kumar, Madeline Tong, Eric D Brown
Clinically approved antibiotics target a narrow spectrum of cellular processes, namely cell wall synthesis, DNA replication, and protein synthesis. Numerous screens have been designed to identify inhibitors that target one of these cellular processes. Indeed, this narrow range of drug mechanisms and a reliance on chemical classes discovered many decades ago are thought to be principally responsible for the current crisis of antibiotic drug resistance. Seeking to expand the target base of antibacterial drug discovery, we developed a nutrient stress screening platform that identifies inhibitors of the growth of in Escherichia coli under nutrient limitation...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29735578/lifestyle-and-environmental-factors-in-multiple-sclerosis
#12
Lars Alfredsson, Tomas Olsson
Lifestyle and environmental factors potently influence the risk of multiple sclerosis (MS), because genetic predisposition only explains a fraction of the risk increase. There is strong evidence for associations of Epstein-Barr virus (EBV) infection, smoking, sun exposure/vitamin D, and adolescent obesity to risk of MS. There is also circumstantial evidence on organic solvents and shift work, all associate with greater risk, although certain factors like nicotine, alcohol, and a high coffee consumption associate with a reduced risk...
May 7, 2018: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/29732937/factors-of-the-epidemiological-triad-that-influence-the-persistence-of-human-papilloma-virus-infection-in-women-with-systemic-lupus-erythematosus
#13
S Méndez-Martínez, M García-Carrasco, E A Jiménez-Herrera, C Mendoza-Pinto, I Etchegaray-Morales, P W Barahona-Rubio, J L Gálvez-Romero, P Munguía-Realpozo, C O Muñóz-Guarneros, M L Cedillo-Ramírez, S E Silva-Gómez, G Linares-Fleites, A Rojas-Vallaraga
We studied the epidemiologic triad-related factors influencing human papilloma virus (HPV) persistence in Mexican women with systemic lupus erythematosus (SLE). Patients aged ≥18 years with SLE (American College of Rheumatology criteria), with and without HPV persistence, were selected. Groups were analyzed by (1) host: clinical disease characteristics; (2) agent: (I) infectious (prevalence, incidence, HPV genotype and co-infections (≥2 HPV genotypes or mycoplasmas)), (II) chemical (contraceptives and immunosuppressive drugs) and (III) physical (vitamin D deficiency) and (3) environment...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29717985/-calcitriol-induced-hypercalcemia-in-a-hunting-dog-with-a-disseminated-paecilomyces-variotii-infection
#14
C Weingart, J Raila, A Lübke-Becker, O Kershaw, M Brunnberg, B Kohn
A 5-year old hunting dog was presented with reduced appetite, weight loss and polyuria/polydipsia. Hematology and clinical chemistry revealed anemia, leukocytosis, increased liver enzymes, hypoalbuminemia and hypercalcemia. The cytological, pathohistological and microbiological examination identified a disseminated infection with the saprophytic mould fungus Paecilomyces variotii in the biopsies of the spleen and a lymph node. Determination of vitamin D metabolites confirmed a calcitriol induced hypercalcemia...
May 2018: Schweizer Archiv Für Tierheilkunde
https://www.readbyqxmd.com/read/29716696/evaluation-of-serum-25-hydroxyvitamin-d-levels-in-calcific-rheumatic-mitral-stenosis-a-cross-sectional-study
#15
Jamal Yusuf, Jothinath P, Saibal Mukhopadhyay, Vickram Vignesh, Sanjay Tyagi
BACKGROUND AND AIM OF THE STUDY: Rheumatic mitral stenosis (RMS) is an autoimmune, progressive destructive valve disease occurring as a sequele of streptococcal infection. Epidemiological studies support an association of vitamin D deficiency with initial susceptibility and severity of autoimmune diseases. The aim of the present study was to assess serum level of 25 hydroxyvitamin D in subjects of RMS and assess if any correlation exists with serum levels of vitamin D and severity of disease along with calcification assessed semi-quantitatively by echocardiography by applying Wilkins score...
March 2018: Indian Heart Journal
https://www.readbyqxmd.com/read/29714447/low-levels-of-vitamin-d-are-associated-with-nosocomial-infections-but-not-with-short-term-mortality-in-critically-ill-patients
#16
Işıl Köse, Çiler Zincircioğlu, Hüseyin Özkarakaş, Meltem Çakmak, Gürsel Ersan, Lütfiye Kuzucu, Şükran Köse, Nimet Şenoğlu
Background/aim: A prospective observational study was conducted to determine the relationship between vitamin D deficiency and nosocomial infections among intensive care unit (ICU) patients. Materials and methods: Demographic data, season of admission, vitamin D levels at admission, premorbid lifestyle scores, comorbid conditions, and admission diagnosis were recorded in 306 ICU patients. Infections that developed at least 48 h after admission to the ICU were the primary outcome, and ICU, hospital, and 1-year mortality were the secondary outcomes...
April 30, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29713871/continued-interest-and-controversy-vitamin-d-in-hiv
#17
REVIEW
Evelyn Hsieh, Michael T Yin
PURPOSE OF REVIEW: Vitamin D (VitD) deficiency is highly prevalent among HIV-infected individuals. Given the overlapping risk for several chronic disease and immunomodulatory outcomes from both long-standing HIV and VitD deficiency, there is great interest in clarifying the clinical role of VitD for this population. RECENT FINDINGS: Recent studies have expanded our knowledge regarding the epidemiology and mechanisms of VitD deficiency-associated outcomes in the setting of HIV...
April 30, 2018: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/29712666/randomized-phase-2-trial-of-monthly-vitamin-d-to-prevent-respiratory-complications-in-children-with-sickle-cell-disease
#18
Margaret T Lee, Meyer Kattan, Ilene Fennoy, Stephen M Arpadi, Rachel L Miller, Serge Cremers, Donald J McMahon, Jeri W Nieves, Gary M Brittenham
In sickle cell disease, respiratory infection and asthma may lead to respiratory complications that are a leading cause of morbidity and mortality. Vitamin D has anti-infective and immunomodulatory effects that may decrease the risk for respiratory infections, asthma, and acute chest syndrome. We conducted a randomized double-blind active-controlled clinical trial to determine whether monthly oral vitamin D3 can reduce the rate of respiratory events in children with sickle cell disease. Seventy sickle cell subjects, ages 3-20 years, with baseline records of respiratory events over 1 year before randomization, underwent screening...
May 8, 2018: Blood Advances
https://www.readbyqxmd.com/read/29709052/can-vitamin-d-help-in-achieving-asthma-control-vitamin-d-revisited-an-updated-insight
#19
Izabela Szymczak, Rafal Pawliczak
Asthma - a prolonged respiratory disease related with hyper-responsiveness and increased inflammation of airways; affects millions peoples worldwide. Vitamin D possess anti-inflammatory and immunomodulatory activities. Its deficiency (the level less than 20 ng/mL in the serum) is found to be related to occurrence of pulmonary diseases including bacterial and viral infections and asthma. Some studies indicate that low levels of vitamin D in the serum are related to reduced lung function and increased airway inflammation as well as overall poor results in asthmatic patients...
2018: Advances in Respiratory Medicine
https://www.readbyqxmd.com/read/29709013/prevalence-of-and-risk-factors-for-low-bone-mineral-density-in-spanish-treated-hiv-infected-patients
#20
Miguel Cervero, Rafael Torres, Jose Luís Agud, Victoria Alcázar, Juan José Jusdado, Concepción García-Lacalle, Santiago Moreno
OBJECTIVES: Several studies have involved antiretroviral therapy in the pathogenesis of low bone mineral density (BMD), while others have not confirmed this association. In this study we analyze the impact of HIV status, traditional risk factors and antiretroviral therapy in BMD in an HIV-infected population living in Madrid. MATERIAL AND METHODS: We performed a cross-sectional analysis of 107 individuals infected with HIV and exposed to antiretroviral treatment to estimate the prevalence of decreased BMD...
2018: PloS One
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