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Vitamin D infections

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https://www.readbyqxmd.com/read/28106720/25-hydroxy-vitamin-d-concentration-is-not-affected-by-severe-or-non-severe-pneumonia-or-inflammation-in-young-children
#1
Johanne Haugen, Ram K Chandyo, Manjeswori Ulak, Maria Mathisen, Sudha Basnet, Karl A Brokstad, Palle Valentiner-Branth, Prakash S Shrestha, Tor A Strand
Poor vitamin D status has been associated with increased risk and severity of respiratory tract infections. Whether or not inflammation and infection affects 25-hydroxy vitamin D (25(OH)D) concentration is controversial and is important in the interpretation of observational studies using plasma-25(OH)D as a biomarker for status. Our objectives were to measure whether 25(OH)D concentration was altered by an episode of acute lower respiratory tract infection and whether markers of inflammation predicted the 25(OH)D concentration...
January 17, 2017: Nutrients
https://www.readbyqxmd.com/read/28105733/vitamin-d-supplementation-for-sickle-cell-disease
#2
REVIEW
Htoo Htoo Kyaw Soe, Adinegara Bl Abas, Nan Nitra Than, Han Ni, Jaspal Singh, Abdul Razzak Bin Mohd Said, Ifeyinwa Osunkwo
BACKGROUND: Sickle cell disease is a genetic chronic haemolytic and pro-inflammatory disorder. The clinical manifestations of sickle cell disease result from the presence of mutations on the beta globin genes that generate an abnormal haemoglobin product (called haemoglobin S) within the red blood cell. Sickle cell disease can lead to many complications such as acute chest syndrome, stroke, acute and chronic bone complications (including painful vaso-occlusive crisis, osteomyelitis, osteonecrosis and osteoporosis)...
January 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28097099/comparison-of-vitamin-d-levels-in-naive-treated-and-inactive-carriers-with-chronic-hepatitis-b-virus
#3
Shahnaz Sali, Soheil Tavakolpour, Baharan Farkhondemehr
Background and Aims: During recent years, the relationship between vitamin D levels and chronic hepatitis B (CHB) infection has attracted many researchers' attention. However, the results relating to the association of vitamin D levels and HBV infection have been conflicting and there remains a lack of knowledge about the effects of antiviral treatments on vitamin D level. Methods: Eighty-four patients with CHB were assessed and divided into three groups: inactive carriers (n = 28), treated (n = 34), and new (treatment-naïve) cases (n = 22)...
December 28, 2016: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/28096657/vitamin-d-deficiency-and-the-risk-of-tuberculosis-a-meta-analysis
#4
Shao-Jun Huang, Xian-Hua Wang, Zhi-Dong Liu, Wen-Li Cao, Yi Han, Ai-Guo Ma, Shao-Fa Xu
BACKGROUND AND AIM: To conduct meta-analyses of all published studies on various aspects of association between vitamin D and tuberculosis (TB). METHODS: PubMed and Web of Knowledge were searched for all properly controlled studies on vitamin D and TB. Pooled odds ratio, mean difference or standardized mean difference, and its corresponding 95% confidence interval were calculated with the Cochrane Review Manager 5.3. RESULTS: A significantly lower vitamin D level was found in TB patients vs controls; vitamin D deficiency (VDD) was associated with an increased risk of TB, although such an association was lacking in the African population and in the human immunodeficiency virus-infected African population...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28094339/massive-effect-on-lncrnas-in-human-monocytes-during-fungal-and-bacterial-infections-and-in-response-to-vitamins-a-and-d
#5
Konstantin Riege, Martin Hölzer, Tilman E Klassert, Emanuel Barth, Julia Bräuer, Maximilian Collatz, Franziska Hufsky, Nelly Mostajo, Magdalena Stock, Bertram Vogel, Hortense Slevogt, Manja Marz
Mycoses induced by C.albicans or A.fumigatus can cause important host damage either by deficient or exaggerated immune response. Regulation of chemokine and cytokine signaling plays a crucial role for an adequate inflammation, which can be modulated by vitamins A and D. Non-coding RNAs (ncRNAs) as transcription factors or cis-acting antisense RNAs are known to be involved in gene regulation. However, the processes during fungal infections and treatment with vitamins in terms of therapeutic impact are unknown...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28094291/differential-effects-of-vitamins-a-and-d-on-the-transcriptional-landscape-of-human-monocytes-during-infection
#6
Tilman E Klassert, Julia Bräuer, Martin Hölzer, Magdalena Stock, Konstantin Riege, Cristina Zubiría-Barrera, Mario M Müller, Silke Rummler, Christine Skerka, Manja Marz, Hortense Slevogt
Vitamin A and vitamin D are essential nutrients with a wide range of pleiotropic effects in humans. Beyond their well-documented roles in cellular differentiation, embryogenesis, tissue maintenance and bone/calcium homeostasis, both vitamins have attracted considerable attention due to their association with-immunological traits. Nevertheless, our knowledge of their immunomodulatory potential during infection is restricted to single gene-centric studies, which do not reflect the complexity of immune processes...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28088363/seasonal-variations-of-u-s-mortality-rates-roles-of-solar-ultraviolet-b-doses-vitamin-d-gene-exp-ression-and-infections
#7
REVIEW
William B Grant, Harjit Pal Bhattoa, Barbara J Boucher
Death rates in the U.S. show a pronounced seasonality. The broad seasonal variation shows about 25% higher death rates in winter than in summer with an additional few percent increase associated with the Christmas and New Year's holidays. A pronounced increase in death rates also starts in mid-September, shortly after the school year begins. The causes of death with large contributions to the observed seasonality include diseases of the circulatory system; the respiratory system; the digestive system; and endocrine, nutritional, and metabolic diseases...
January 11, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28079241/is-there-an-association-between-vitamin-d-and-liver-fibrosis-in-patients-with-chronic-hepatitis-c
#8
Kalinca da Silva Oliveira, Caroline Buss, Cristiane Valle Tovo
BACKGROUND: - Vitamin D is known for its immunomodulatory, anti-inflammatory and antifibrotic properties, which are quite relevant in the pathogenesis and treatment of many causes of chronic liver disease. OBJECTIVE: - This study aimed to evaluate the association between serum vitamin D levels and the histopathological findings in patients with chronic hepatitis C virus infection. METHODS: - Cross-sectional study composed of patients with chronic hepatitis C...
January 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28079172/25-oh-d-and-1-25-oh-d-vitamin-d-fails-to-predict-sepsis-and-mortality-in-a-prospective-cohort-study
#9
Franz Ratzinger, Helmuth Haslacher, Markus Stadlberger, Ralf L J Schmidt, Markus Obermüller, Klaus G Schmetterer, Thomas Perkmann, Athanasios Makristathis, Rodrig Marculescu, Heinz Burgmann
The clinical role of vitamin D in sepsis and mortality prediction is controversially discussed. Therefore, we conducted a prospective cohort study on standard care wards, including 461 patients with suspected sepsis fulfilling two or more SIRS criteria. On the first and third day after onset of SIRS symptoms levels of 25(OH)D, 1,25(OH)D and sepsis biomarkers were analysed for their predictive capacity for identifying infection, bacteraemia and an elevated mortality risk. Additionally, several SNPs associated with vitamin D metabolism were evaluated...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28078341/the-role-of-uv-radiation-and-vitamin-d-in-the-seasonality-and-outcomes-of-infectious-disease
#10
Abhimanyu, Anna K Coussens
The seasonality of infectious disease outbreaks suggests that environmental conditions have a significant effect on disease risk. One of the major environmental factors that can affect this is solar radiation, primarily acting through ultraviolet radiation (UVR), and its subsequent control of vitamin D production. Here we show how UVR and vitamin D, which are modified by latitude and season, can affect host and pathogen fitness and relate them to the outcomes of bacterial, viral and vector-borne infections...
January 12, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28072933/altered-blood-levels-of-vitamin-d-cathelicidin-and-parathyroid-hormone-in-patients-with-sepsis-a-pilot-study
#11
T Greulich, W Regner, M Branscheidt, C Herr, A R Koczulla, C F Vogelmeier, R Bals
It has been recognised that vitamin D (VitD) has a potential role in the regulation of inflammation and protection from infection. In a prospective clinical observational pilot study, we investigated the serum levels of 25-hydroxyvitamin-D3 (25(OH)D3), 1,25-hydroxyvitamin-D3 (1,25(OH)2D3), parathyroid hormone (PTH), and cathelicidin in intensive care unit (ICU) patients with or without systemic inflammatory response syndrome (SIRS). We included 32 patients with SIRS (septic patients), 16 ICU patients without SIRS, and 16 healthy controls...
January 2017: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/28065420/effectiveness-of-dietary-supplements-in-spinal-cord-injury-subjects
#12
REVIEW
Angela Navarrete-Opazo, Pilar Cuitiño, Inés Salas
BACKGROUND: Individuals with spinal cord injury (SCI) consume more dietary supplements than the general population. However, there is limited information regarding the clinical effectiveness of dietary supplements in SCI population. OBJECTIVE: To systematically review the effectiveness of dietary supplements for the prevention or treatment of health-related conditions associated with SCI. METHODS: Randomized or non-randomized controlled clinical trials were selected, comparing the effect of any dose and form of a dietary supplement (defined by the Dietary Supplement Health and Education Act), with either no treatment, placebo, or other medication...
December 19, 2016: Disability and Health Journal
https://www.readbyqxmd.com/read/28063200/effects-of-1-25-oh-2-d3-and-vitamin-d-receptor-on-peripheral-cd4-cd8-double-positive-t-lymphocytes-in-a-mouse-model-of-systemic-lupus-erythematosus
#13
Yan Ding, Wang Liao, Xiao-Jie He, Wei Xiang
This study aims to explore effects of 1,25(OH)2 D3 and vitamin D receptor (VDR) on peripheral CD4(+) /CD8(+) double-positive (DP) T lymphocytes in systemic lupus erythematosus (SLE). MRL-LPr/LPr mice with SLE (n = 20) and normal MRL mice (n = 20) were assigned into the control group (normal mice, without feeding with 1,25(OH)2 D3 ), the 1,25(OH)2 D3 group (SLE mice, feeding with 1,25(OH)2 D3 ), the VDR-knock-in + 1,25(OH)2 D3 group (SLE mice, VDR-knock-in, feeding with 1,25(OH)2 D3 ) and the VDR-knockout group (normal mice, VDR-knockout, without feeding with 1,25(OH)2 D3 ) (n = 10 per group)...
January 7, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28060020/significant-association-between-statin-associated-myalgia-and-vitamin-d-deficiency-among-treated-hiv-infected-patients
#14
Leonardo Calza, Eleonora Magistrelli, Vincenzo Colangeli, Marco Borderi, Ilaria Contadini, Isabella Bon, Maria Carla Re, Pierluigi Viale
BACKGROUND.: Several studies have shown a significant association between vitamin D deficiency and an increased risk of statin-related symptomatic myalgia in the general population, but there are no data among HIV-infected persons. METHODS.: A retrospective, cohort study was conducted to assess the incidence of symptomatic myalgia and elevation in serum creatine kinase (CK) level among HIV-positive adults on cART and treated with atorvastatin or rosuvastatin for at least 12 months between 2011 and 2015 in our Outpatient Unit...
January 4, 2017: AIDS
https://www.readbyqxmd.com/read/28058015/vitamin-d-differentially-regulates-salmonella-induced-intestine-epithelial-autophagy-and-interleukin-1%C3%AE-expression
#15
Fu-Chen Huang
AIM: To investigate the effects of active vitamin D3 on autophagy and interleukin (IL)-1β expression in Salmonella-infected intestinal epithelial cells (IECs). METHODS: Caco-2 cells, NOD2 siRNA-, Atg16L1 siRNA- or vitamin D receptor (VDR) siRNA-transfected Caco-2 cells were pretreated with 1,25-dihydroxyvitamin D3 (1,25D3), and then infected by wild-type S. typhimurium strain SL1344. The conversion of LC3-I to LC3-II was detected by Western blot analysis and LC3(+) autophagosome was analyzed by immunofluorescence...
December 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28052885/a-micronutrient-fortified-young-child-formula-improves-the-iron-and-vitamin-d-status-of-healthy-young-european-children-a-randomized-double-blind-controlled-trial
#16
Marjolijn D Akkermans, Simone Rbm Eussen, Judith M van der Horst-Graat, Ruurd M van Elburg, Johannes B van Goudoever, Frank Brus
BACKGROUND: Iron deficiency (ID) and vitamin D deficiency (VDD) are common among young European children because of low dietary intakes and low compliance to vitamin D supplementation policies. Milk is a common drink for young European children. Studies evaluating the effect of milk fortification on iron and vitamin D status in these children are scarce. OBJECTIVE: We aimed to investigate the effect of a micronutrient-fortified young-child formula (YCF) on the iron and vitamin D status of young European children...
January 4, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28049048/vitamin-d-in-autoimmune-rheumatic-diseases-a-view-inside-gender-differences
#17
REVIEW
Massimiliano Vasile, Clarissa Corinaldesi, Cristina Antinozzi, Clara Crescioli
A large body of evidence highlights the role for vitamin D deficiency/insufficiency in rheumatic diseases, a group of different pathologies mostly of autoimmune origin. Vitamin D and vitamin D receptor agonists exquisitely modulate the immune system against over-reactivity towards tolerance; on this basis, vitamin D could be a good therapeutic candidate to control autoimmune processes in rheumatic diseases. Similarly, to other autoimmune pathologies, rheumatic diseases show a significant female bias. This sexual dimorphism seems, in part, to rely on the different sex hormone-induced regulation on male and female immune systems...
December 31, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28045766/baseline-vitamin-d-deficiency-decreases-the-effectiveness-of-statins-in-hiv-infected-adults-on-antiretroviral-therapy
#18
Corrilynn O Hileman, Vin Tangpricha, Abdus Sattar, Grace A McComsey
OBJECTIVE: Vitamin D deficiency is common in HIV. Statins may increase vitamin D and it is unknown whether vitamin D modifies the effect of statins on cardiovascular disease. DESIGN: SATURN-HIV was a 96-week, randomized, placebo-controlled trial designed to evaluate the effect of rosuvastatin on immune activation and subclinical vascular disease in HIV-infected adults on antiretroviral therapy. This analysis focuses on the pre-specified secondary endpoint 25-hydroxyvitamin D [25(OH)D] concentrations...
December 29, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28025971/-primary-and-secondary-prevention-of-hip-fragility-fracture-in-teruel-health-sector-aragon-spain
#19
Rafael Gómez Navarro, Paloma González García, Carlos Martín Hernández, Ángel Castro Sauras, Santiago Valdearcos Enguídanos
OBJECTIVE: Osteoporosis should be prevented, diagnosed and treated, preferably before the fragility fracture occurs. The objective was to analyze primary and secondary interventions carried out in individuals diagnosed with femur fragility fracture at Teruel in 2014. METHODS: Descriptive retrospective study. Variables assessed were sex, age, main health district, place of residence, basal functional situation, diagnosis on osteoporosis, hip or vertebral fracture, loss of height, use of FRAX tool, treatment on discharge, survival and cause of exitus...
January 2, 2017: Revista Española de Salud Pública
https://www.readbyqxmd.com/read/28025175/vitamin-d-deficiency-and-the-pathogenesis-of-crohn-s-disease
#20
REVIEW
John H White
Vitamin D has emerged as a key regulator of innate immune responses to pathogen threat. The hormonal form of vitamin D signals through a nuclear receptor transcription factor and regulates gene transcription. Several papers have shown that vitamin D signaling is active both upstream and downstream of pattern recognition receptors, vanguards of innate immune responses. Crohn's disease (CD) is a relapsing-recurring inflammatory bowel disease (IBD) that arises from dysregulated intestinal innate immunity. Indeed, genetic studies have identified several CD susceptibility markers linked to mechanisms of innate immune responses to infection...
December 23, 2016: Journal of Steroid Biochemistry and Molecular Biology
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