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https://www.readbyqxmd.com/read/29127672/responsible-conduct-of-human-subjects-research-in-islamic-communities
#1
Aceil Al-Khatib, Michael Kalichman
In order to increase understanding of the ethical implications of biomedical, behavioral and clinical research, the Fogarty International Center, part of the United States National Institutes of Health, established an International Research Ethics Education and Curriculum Development Award (R25) to support programs in low- and middle-income countries. To develop research ethics expertise in Jordan, the University of California San Diego fellowship program in collaboration with Jordan University of Science and Technology provides courses that enable participants to develop skills in varied research ethics topics, including research with human subjects...
November 10, 2017: Science and Engineering Ethics
https://www.readbyqxmd.com/read/29024108/changes-in-hepatic-glucose-and-lipid-metabolism-related-parameters-in-domestic-pigeon-columba-livia-during-incubation-and-chick-rearing
#2
X P Wan, P Xie, Z Bu, X T Zou
This study aimed to evaluate the hepatic glucose and lipid metabolism-related parameters of adult male and female White King pigeons (Columba livia) during incubation and chick rearing. At day 4 (I4), 10 (I10) and 17 (I17) of incubation and day 1 (R1), 7 (R7), 15 (R15) and 25 (R25) of chick rearing, livers were sampled from six pigeons for each sex. Glycogen and fat contents, activities of glycolytic enzymes (hexokinase, HK; 6-phosphofructokinase, 6-PFK), and genes expressions of key enzymes involved in glycolysis (pyruvate kinase, PK; glucokinase, GK), gluconeogenesis (phosphoenolpyruvate carboxykinase cytosolic, PCK1; fructose-1,6-bisphosphatase, FBP1; glucose-6-phosphatase, G6Pase), fatty acid synthesis (fatty acid synthase, FAS; acetyl-CoA carboxylase, ACC) and fatty acid β-oxidation (carnitine palmitoyltransferase 1, CPT1; acyl-CoA 1, ACO) were measured...
October 12, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29019548/noncontact-three-dimensional-evaluation-of-surface-alterations-and-wear-in-niti-endodontic-instruments
#3
Fabiano Guerra Ferreira, Igor Bastos Barbosa, Pantaleo Scelza, Marcello Bulhões Montagnana, Daniel Russano, John Neff, Miriam Zaccaro Scelza
The aim of this study was to undertake a qualitative and quantitative assessment of nanoscale alterations and wear on the surfaces of nickel-titanium (NiTi) endodontic instruments, before and after use, through a high-resolution, noncontact, three-dimensional optical profiler, and to verify the accuracy of the evaluation method. Cutting blade surfaces of two different brands of NiTi endodontic instruments, Reciproc R25 (n = 5) and WaveOne Primary (n = 5), were examined and compared before and after two uses in simulated root canals made in clear resin blocks...
September 28, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28967447/comfort%C3%A2-sm-communication-for-oncology-nurses-program-overview-and-preliminary-evaluation-of-a-nationwide-train-the-trainer-course
#4
Elaine Wittenberg, Betty Ferrell, Joy Goldsmith, Sandra L Ragan, Haley Buller
OBJECTIVE: The COMFORT Communication Course for Oncology Nurses is a train-the-trainer program funded by the National Cancer Institute (R25) that provides nationwide communication training to improve patient-centered communication in cancer care. The purpose of this article is to provide an overview of the program and present an evaluation of three courses. METHODS: The curriculum contains seven modules addressing palliative care communication. Pre-course survey of needs, post-course feedback, and follow-up at 6 and 12 months were used to evaluate the program...
September 22, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/28814328/building-capacity-for-dissemination-and-implementation-research-one-university-s-experience
#5
Ross C Brownson, Enola K Proctor, Douglas A Luke, Ana A Baumann, Mackenzie Staub, Matthew T Brown, Mallory Johnson
BACKGROUND: While dissemination and implementation (D&I) science has grown rapidly, there is an ongoing need to understand how to build and sustain capacity in individuals and institutions conducting research. There are three inter-related domains for capacity building: people, settings, and activities. Since 2008, Washington University in St. Louis has dedicated significant attention and resources toward building D&I research capacity. This paper describes our process, challenges, and lessons with the goal of informing others who may have similar aims at their own institution...
August 16, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28808639/comparison-of-cyclic-fatigue-life-of-nickel-titanium-files-an-examination-using-high-speed-camera
#6
Taha Özyürek, Neslihan Büşra Keskin, Fatma Furuncuoğlu, Uğur İnan
OBJECTIVES: To determine the actual revolutions per minute (rpm) values and compare the cyclic fatigue life of Reciproc (RPC, VDW GmbH), WaveOne (WO, Dentsply Maillefer), and TF Adaptive (TFA, Axis/SybronEndo) nickel-titanium (NiTi) file systems using high-speed camera. MATERIALS AND METHODS: Twenty RPC R25 (25/0.08), 20 WO Primary (25/0.08), and 20 TFA ML 1 (25/0.08) files were employed in the present study. The cyclic fatigue tests were performed using a dynamic cyclic fatigue testing device, which has an artificial stainless steel canal with a 60° angle of curvature and a 5-mm radius of curvature...
August 2017: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/28745230/bupivacaine-s75-r25-loaded-in-nanostructured-lipid-carriers-factorial-design-hplc-quantification-method-and-physicochemical-stability-study
#7
Gustavo Henrique Rodrigues Da Silva, Ligia Nunes de Moraes Ribeiro, Viviane Guilherme, Simone Ramos de Castro, Márcia Cristina Breitkreitz, Eneida de Paula
Bupivacaine is the most used local anesthetic in surgical procedures, producing prolonged anesthesia. The major limiting factor for the clinical use of bupivacaine comes from its systemic toxicity. Nanostructured lipid carriers (NLC) are vehicles for sustained drug delivery that are able to minimize the toxicity and to increase the action time of lipophilic drugs. This work reports a 22 factorial design, which elucidate the role of the lipids mixture in the NLC, towards an optimized formulation. It also provides a new method for Bupivacaine S75:R25 (BVCS75) quantification in NLC...
July 26, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28735793/dentinal-microcrack-development-after-canal-preparation-a-longitudinal-in-situ-micro-computed-tomography-study-using-a-cadaver-model
#8
Gustavo De-Deus, Júlio César de Azevedo Carvalhal, Felipe Gonçalves Belladonna, Emmanuel João Nogueira Leal Silva, Ricardo Tadeu Lopes, Renato Evando Moreira Filho, Erick Miranda Souza, José Claudio Provenzano, Marco Aurélio Versiani
INTRODUCTION: The purpose of this study was to evaluate the development of dentinal microcracks after root canal preparation with Reciproc and ProTaper Universal systems using an in situ cadaver model by means of a micro-computed tomography (micro-CT) imaging system. METHODS: At autopsy, 8 maxillary bone blocks having at least the first and second premolar teeth (n = 16) were excised, scanned at a resolution of 13.18 μm, and randomly distributed into 2 groups (n = 8) according to the preparation protocol: Reciproc and ProTaper Universal systems...
July 20, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28733080/cyclic-fatigue-resistance-of-reciproc-blue-and-reciproc-files-in-an-s-shaped-canal
#9
Hüseyin Sinan Topçuoğlu, Gamze Topçuoğlu
INTRODUCTION: This study evaluated the cyclic fatigue resistance (CFR) of Reciproc (R25 and R40; VDW, Munich, Germany) and Reciproc Blue (R25 and R40, VDW) instruments used in an artificial S-shaped canal. METHODS: A total of 80 files were tested in an S-shaped canal (n = 20 for each file, Reciproc R25 and R40 and Reciproc Blue R25 and R40). This study compared Reciproc R25 with Reciproc Blue R25 files and Reciproc R40 with Reciproc Blue R40 files. All files were rotated in an S-shaped artificial canal until fracture...
October 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28669105/effect-of-root-canal-preparation-techniques-on-chlorhexidine-substantivity-on-human-dentin-a-chemical-analysis
#10
Matheus Albino Souza, Carine Zen Menon, Louise Fochesatto Nery, Charise Dallazem Bertol, Luciana Grazziotin Rossato-Grando, Doglas Cecchin
OBJECTIVES: Chlorhexidine binds to dentine to provide sustained action. The aim of the present study was to evaluate and compare the substantivity of chlorhexidine using manual, rotary, and reciprocating systems for root canal preparation. METHODS: Forty-five extracted human single-rooted teeth were used for this study. The samples were divided into three groups (n = 15) according to the instrumentation technique used: manual instrumentation (K-File), rotary instrumentation (ProTaper), and reciprocating instrumentation (Reciproc R25)...
July 1, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28662877/cyclic-fatigue-resistance-of-reciproc-blue-reciproc-and-waveone-gold-reciprocating-instruments
#11
Cangül Keskin, Uğur Inan, Murat Demiral, Ali Keleş
INTRODUCTION: The aim of the present study was to compare the cyclic fatigue resistance of Reciproc Blue R25 (VDW, Munich, Germany) with Reciproc R25 (VDW) and WaveOne Gold Primary (Denstply Maillefer, Ballaigues, Switzerland). METHODS: Fifteen Reciproc Blue R25, 15 Reciproc R25, and 15 WaveOne Gold Primary instruments were collected and tested in a dynamic cyclic fatigue test device, which has an artificial canal with a 60° angle of curvature and a 5-mm radius of curvature...
June 26, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28655546/optimised-nlc-a-nanotechnological-approach-to-improve-the-anaesthetic-effect-of-bupivacaine
#12
Gustavo H Rodrigues da Silva, Lígia N M Ribeiro, Hery Mitsutake, Viviane A Guilherme, Simone R Castro, Ronei J Poppi, Márcia C Breitkreitz, Eneida de Paula
The short time of action and systemic toxicity of local anaesthetics limit their clinical application. Bupivacaine is the most frequently used local anaesthetic in surgical procedures worldwide. The discovery that its S(-) enantiomeric form is less toxic than the R(+) form led to the introduction of products with enantiomeric excess (S75:R25 bupivacaine) in the market. Nevertheless, the time of action of bupivacaine is still short; to overcome that, bupivacaine S75:R25 (BVCS75) was encapsulated in nanostructured lipid carriers (NLC)...
June 24, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28541536/acclimation-of-light-and-dark-respiration-to-experimental-and-seasonal-warming-are-mediated-by-changes-in-leaf-nitrogen-in-eucalyptus-globulus
#13
K Y Crous, G Wallin, O K Atkin, J Uddling, A Af Ekenstam
Quantifying the adjustments of leaf respiration in response to seasonal temperature variation and climate warming is crucial because carbon loss from vegetation is a large but uncertain part of the global carbon cycle. We grew fast-growing Eucalyptus globulus Labill. trees exposed to +3 °C warming and elevated CO2 in 10-m tall whole-tree chambers and measured the temperature responses of leaf mitochondrial respiration, both in light (RLight) and in darkness (RDark), over a 20-40 °C temperature range and during two different seasons...
August 1, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28527852/cyclic-and-torsional-fatigue-resistance-of-reciprocating-single-files-manufactured-by-different-nickel-titanium-alloys
#14
Murilo P Alcalde, Mario Tanomaru-Filho, Clovis M Bramante, Marco Antonio H Duarte, Juliane Maria Guerreiro-Tanomaru, Jader Camilo-Pinto, Marcus Vinicius Reis Só, Rodrigo Ricci Vivan
INTRODUCTION: The aim of this study was to evaluate the cyclic and torsional fatigue resistance of the following reciprocating single-file systems: ProDesign R 25.06 (Easy Equipamentos Odontológicos, Belo Horizonte, Brazil), Reciproc R25 (VDW GmbH, Munich, Germany), and Unicone L25 (Medin SA, Nové Město in Moravě, Czech Republic). METHODS: Sixty instruments of the ProDesign R, Reciproc R25, and Unicone L25 systems (n = 20) were used. Cyclic fatigue resistance was tested measuring the time to failure in an artificial stainless steel canal with a 60° angle and a 5-mm radius of curvature (n = 10)...
May 17, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28527845/cyclic-fatigue-resistance-of-oneshape-hyflex-edm-waveone-gold-and-reciproc-blue-nickel-titanium-instruments
#15
Mustafa Gündoğar, Taha Özyürek
INTRODUCTION: The purpose of this study was to compare the cyclic fatigue resistances of Reciproc Blue (VDW, Munich, Germany), HyFlex EDM (Coltene/Whaledent, Altstätten, Switzerland), WaveOne Gold (Dentsply Maillefer, Ballaigues, Switzerland), and OneShape (Micro Mega, Besancon, France) single-file NiTi systems. METHODS: Thirty Reciproc Blue R25 (25/.08), 30 HyFlex EDM (25/.∼), 30 WaveOne Gold Primary (25/.07), and 30 OneShape (25/.06) instruments were included in this study...
May 17, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28503479/cyclic-fatigue-life-of-tango-endo-waveone-gold-and-reciproc-niti-instruments
#16
Koray Yılmaz, Taha Özyürek
OBJECTIVES: To compare the fatigue life of Tango-Endo, WaveOne GOLD, and Reciproc NiTi instruments under static model via artificial canals with different angles of curvature. MATERIALS AND METHODS: Reciproc R25, WaveOne GOLD Primary, and Tango-Endo instruments were included in this study (n = 20). All the instruments were rotated in artificial canals which were made of stainless steel with an inner diameter of 1.5 mm, 45°, 60°, and 90° angles of curvatures and a radius of curvature of 5 mm until fracture occurred, and the time to fracture was recorded in seconds using a digital chronometer...
May 2017: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/28470953/mechanical-characteristics-of-counterfeit-reciproc-instruments-a-call-for-attention
#17
C S Rodrigues, V T L Vieira, H S Antunes, G De-Deus, C N Elias, E J L Moreira, E J N L Silva
AIM: To report here the main differences between the visual aspects of original and counterfeit Reciproc instruments, together with an evaluation of instrument bending resistance, cyclic fatigue, surface finish, Vickers microhardness, and chemical composition. METHODOLOGY: The visual aspects of original Reciproc R25 (VDW, Munich, Germany) and counterfeit Reciproc R25 instruments (claimed to be original, supposedly with dimensions similar to those of Reciproc R25 files, bought at www...
May 4, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28470747/effect-of-interrupted-motion-on-the-cyclic-fatigue-resistance-of-reciprocating-nickel-titanium-instruments
#18
C Keskin, U Inan, M Demiral
AIM: To compare the cyclic fatigue resistances of WaveOne Gold (Denstply Sirona, Ballaigues, Switzerland), WaveOne (Dentsply Sirona), and Reciproc (VDW, Munich, Germany) in interrupted reciprocation. METHODOLOGY: Three groups of 18 instruments each of WaveOne Gold Primary, WaveOne Primary, and Reciproc R25 were subjected to cyclic fatigue tests in reciprocation and interrupted reciprocation. The instruments in group 1 were tested in reciprocation, whereas in groups 2 and 3, reciprocation was interrupted for 1 s in every 5 s and 10 s, respectively...
May 4, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28470584/myelin-basic-protein-citrullination-a-hallmark-of-central-nervous-system-demyelination-assessed-by-novel-monoclonal-antibodies-in-prion-diseases
#19
Byungki Jang, Yong-Chul Jeon, Hae-Young Shin, Yun-Jung Lee, Hyunji Kim, Yoshitaka Kondo, Akihito Ishigami, Yong-Sun Kim, Eun-Kyoung Choi
Myelin basic protein (MBP) citrullination by peptidylarginine deiminase (PAD) enzymes leads to incomplete protein-lipid bilayer interactions and vulnerability to proteolytic enzymes, resulting in disorganization of the myelin sheath in the central nervous system. Therefore, citrullinated MBP (citMBP) has been suggested as a hallmark of demyelination, but how citMBP is implicated in prion diseases remains unknown. For the first time, we developed mouse monoclonal anti-citMBP IgG1 (clones 1B8, 1H1, and 3C6) and IgM (clone 3G5) antibodies that recognize human citMBP at its R25, R122, and R130 residues and at its C-terminal region (or the corresponding sites in mouse MBP), respectively...
May 3, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28467618/effectiveness-of-xp-endo-finisher-and-xp-endo-finisher-r-in-removing-root-filling-remnants-a-micro-ct-study
#20
E J N L Silva, F G Belladonna, A S Zuolo, E Rodrigues, I C Ehrhardt, E M Souza, G De-Deus
AIM: To evaluate the efficacy of filling material removal from oval-shaped canals after the use of supplementary files (XP-endo Finisher and XP-endo Finisher R) through micro-computed tomographic (micro-CT) analysis. METHODOLOGY: The root canals of twenty maxillary single-rooted teeth were prepared with Reciproc R25 files and filled with gutta-percha and AH Plus sealer using the continuous wave of condensation technique. The root canals were then retreated using Reciproc R25 and R40 instruments...
May 3, 2017: International Endodontic Journal
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