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https://www.readbyqxmd.com/read/28745230/bupivacaine-s75-r25-loaded-in-nanostructured-lipid-carriers-factorial-design-hplc-quantification-method-and-physicochemical-stability-study
#1
Gustavo Henrique Rodrigues Da Silva, Ligia Nunes de Moraes Ribeiro, Viviane Guilherme, Simone Ramos de Castro, Márcia Cristina Breitkreitz, Eneida de Paula
Bupivacaine is the most used local anesthetic in surgical procedures, producing prolonged anesthesia. The major limiting factor for the clinical use of bupivacaine comes from its systemic toxicity. Nanostructured lipid carriers (NLC) are vehicles for sustained drug delivery that are able to minimize the toxicity and to increase the action time of lipophilic drugs. This work reports a 22 factorial design, which elucidate the role of the lipids mixture in the NLC, towards an optimized formulation. It also provides a new method for Bupivacaine S75:R25 (BVCS75) quantification in NLC...
July 26, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28735793/dentinal-microcrack-development-after-canal-preparation-a-longitudinal-in-situ-micro-computed-tomography-study-using-a-cadaver-model
#2
Gustavo De-Deus, Júlio César de Azevedo Carvalhal, Felipe Gonçalves Belladonna, Emmanuel João Nogueira Leal Silva, Ricardo Tadeu Lopes, Renato Evando Moreira Filho, Erick Miranda Souza, José Claudio Provenzano, Marco Aurélio Versiani
INTRODUCTION: The purpose of this study was to evaluate the development of dentinal microcracks after root canal preparation with Reciproc and ProTaper Universal systems using an in situ cadaver model by means of a micro-computed tomography (micro-CT) imaging system. METHODS: At autopsy, 8 maxillary bone blocks having at least the first and second premolar teeth (n = 16) were excised, scanned at a resolution of 13.18 μm, and randomly distributed into 2 groups (n = 8) according to the preparation protocol: Reciproc and ProTaper Universal systems...
July 20, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28733080/cyclic-fatigue-resistance-of-reciproc-blue-and-reciproc-files-in-an-s-shaped-canal
#3
Hüseyin Sinan Topçuoğlu, Gamze Topçuoğlu
INTRODUCTION: This study evaluated the cyclic fatigue resistance (CFR) of Reciproc (R25 and R40; VDW, Munich, Germany) and Reciproc Blue (R25 and R40, VDW) instruments used in an artificial S-shaped canal. METHODS: A total of 80 files were tested in an S-shaped canal (n = 20 for each file, Reciproc R25 and R40 and Reciproc Blue R25 and R40). This study compared Reciproc R25 with Reciproc Blue R25 files and Reciproc R40 with Reciproc Blue R40 files. All files were rotated in an S-shaped artificial canal until fracture...
July 18, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28669105/effect-of-root-canal-preparation-techniques-on-chlorhexidine-substantivity-on-human-dentin-a-chemical-analysis
#4
Matheus Albino Souza, Carine Zen Menon, Louise Fochesatto Nery, Charise Dallazem Bertol, Luciana Grazziotin Rossato-Grando, Doglas Cecchin
OBJECTIVES: Chlorhexidine binds to dentine to provide sustained action. The aim of the present study was to evaluate and compare the substantivity of chlorhexidine using manual, rotary, and reciprocating systems for root canal preparation. METHODS: Forty-five extracted human single-rooted teeth were used for this study. The samples were divided into three groups (n = 15) according to the instrumentation technique used: manual instrumentation (K-File), rotary instrumentation (ProTaper), and reciprocating instrumentation (Reciproc R25)...
July 1, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28662877/cyclic-fatigue-resistance-of-reciproc-blue-reciproc-and-waveone-gold-reciprocating-instruments
#5
Cangül Keskin, Uğur Inan, Murat Demiral, Ali Keleş
INTRODUCTION: The aim of the present study was to compare the cyclic fatigue resistance of Reciproc Blue R25 (VDW, Munich, Germany) with Reciproc R25 (VDW) and WaveOne Gold Primary (Denstply Maillefer, Ballaigues, Switzerland). METHODS: Fifteen Reciproc Blue R25, 15 Reciproc R25, and 15 WaveOne Gold Primary instruments were collected and tested in a dynamic cyclic fatigue test device, which has an artificial canal with a 60° angle of curvature and a 5-mm radius of curvature...
June 26, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28655546/optimised-nlc-a-nanotechnological-approach-to-improve-the-anaesthetic-effect-of-bupivacaine
#6
Gustavo H Rodrigues da Silva, Lígia N M Ribeiro, Hery Mitsutake, Viviane A Guilherme, Simone R Castro, Ronei J Poppi, Márcia C Breitkreitz, Eneida de Paula
The short time of action and systemic toxicity of local anaesthetics limit their clinical application. Bupivacaine is the most frequently used local anaesthetic in surgical procedures worldwide. The discovery that its S(-) enantiomeric form is less toxic than the R(+) form led to the introduction of products with enantiomeric excess (S75:R25 bupivacaine) in the market. Nevertheless, the time of action of bupivacaine is still short; to overcome that, bupivacaine S75:R25 (BVCS75) was encapsulated in nanostructured lipid carriers (NLC)...
June 24, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28541536/acclimation-of-light-and-dark-respiration-to-experimental-and-seasonal-warming-are-mediated-by-changes-in-leaf-nitrogen-in-eucalyptus-globulus
#7
K Y Crous, G Wallin, O K Atkin, J Uddling, A Af Ekenstam
Quantifying the adjustments of leaf respiration in response to seasonal temperature variation and climate warming is crucial because carbon loss from vegetation is a large but uncertain part of the global carbon cycle. We grew fast-growing Eucalyptus globulus Labill. trees exposed to +3 °C warming and elevated CO2 in 10-m tall whole-tree chambers and measured the temperature responses of leaf mitochondrial respiration, both in light (RLight) and in darkness (RDark), over a 20-40 °C temperature range and during two different seasons...
May 24, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28527852/cyclic-and-torsional-fatigue-resistance-of-reciprocating-single-files-manufactured-by-different-nickel-titanium-alloys
#8
Murilo P Alcalde, Mario Tanomaru-Filho, Clovis M Bramante, Marco Antonio H Duarte, Juliane Maria Guerreiro-Tanomaru, Jader Camilo-Pinto, Marcus Vinicius Reis Só, Rodrigo Ricci Vivan
INTRODUCTION: The aim of this study was to evaluate the cyclic and torsional fatigue resistance of the following reciprocating single-file systems: ProDesign R 25.06 (Easy Equipamentos Odontológicos, Belo Horizonte, Brazil), Reciproc R25 (VDW GmbH, Munich, Germany), and Unicone L25 (Medin SA, Nové Město in Moravě, Czech Republic). METHODS: Sixty instruments of the ProDesign R, Reciproc R25, and Unicone L25 systems (n = 20) were used. Cyclic fatigue resistance was tested measuring the time to failure in an artificial stainless steel canal with a 60° angle and a 5-mm radius of curvature (n = 10)...
May 17, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28527845/cyclic-fatigue-resistance-of-oneshape-hyflex-edm-waveone-gold-and-reciproc-blue-nickel-titanium-instruments
#9
Mustafa Gündoğar, Taha Özyürek
INTRODUCTION: The purpose of this study was to compare the cyclic fatigue resistances of Reciproc Blue (VDW, Munich, Germany), HyFlex EDM (Coltene/Whaledent, Altstätten, Switzerland), WaveOne Gold (Dentsply Maillefer, Ballaigues, Switzerland), and OneShape (Micro Mega, Besancon, France) single-file NiTi systems. METHODS: Thirty Reciproc Blue R25 (25/.08), 30 HyFlex EDM (25/.∼), 30 WaveOne Gold Primary (25/.07), and 30 OneShape (25/.06) instruments were included in this study...
May 17, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28503479/cyclic-fatigue-life-of-tango-endo-waveone-gold-and-reciproc-niti-instruments
#10
Koray Yılmaz, Taha Özyürek
OBJECTIVES: To compare the fatigue life of Tango-Endo, WaveOne GOLD, and Reciproc NiTi instruments under static model via artificial canals with different angles of curvature. MATERIALS AND METHODS: Reciproc R25, WaveOne GOLD Primary, and Tango-Endo instruments were included in this study (n = 20). All the instruments were rotated in artificial canals which were made of stainless steel with an inner diameter of 1.5 mm, 45°, 60°, and 90° angles of curvatures and a radius of curvature of 5 mm until fracture occurred, and the time to fracture was recorded in seconds using a digital chronometer...
May 2017: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/28470953/mechanical-characteristics-of-counterfeit-reciproc-instruments-a-call-for-attention
#11
C S Rodrigues, V T L Vieira, H S Antunes, G De-Deus, C N Elias, E J L Moreira, E J N L Silva
AIM: To report here the main differences between the visual aspects of original and counterfeit Reciproc instruments, together with an evaluation of instrument bending resistance, cyclic fatigue, surface finish, Vickers microhardness, and chemical composition. METHODOLOGY: The visual aspects of original Reciproc R25 (VDW, Munich, Germany) and counterfeit Reciproc R25 instruments (claimed to be original, supposedly with dimensions similar to those of Reciproc R25 files, bought at www...
May 4, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28470747/effect-of-interrupted-motion-on-the-cyclic-fatigue-resistance-of-reciprocating-nickel-titanium-instruments
#12
C Keskin, U Inan, M Demiral
AIM: To compare the cyclic fatigue resistances of WaveOne Gold (Denstply Sirona, Ballaigues, Switzerland), WaveOne (Dentsply Sirona), and Reciproc (VDW, Munich, Germany) in interrupted reciprocation. METHODOLOGY: Three groups of 18 instruments each of WaveOne Gold Primary, WaveOne Primary, and Reciproc R25 were subjected to cyclic fatigue tests in reciprocation and interrupted reciprocation. The instruments in group 1 were tested in reciprocation, whereas in groups 2 and 3, reciprocation was interrupted for 1 s in every 5 s and 10 s, respectively...
May 4, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28470584/myelin-basic-protein-citrullination-a-hallmark-of-central-nervous-system-demyelination-assessed-by-novel-monoclonal-antibodies-in-prion-diseases
#13
Byungki Jang, Yong-Chul Jeon, Hae-Young Shin, Yun-Jung Lee, Hyunji Kim, Yoshitaka Kondo, Akihito Ishigami, Yong-Sun Kim, Eun-Kyoung Choi
Myelin basic protein (MBP) citrullination by peptidylarginine deiminase (PAD) enzymes leads to incomplete protein-lipid bilayer interactions and vulnerability to proteolytic enzymes, resulting in disorganization of the myelin sheath in the central nervous system. Therefore, citrullinated MBP (citMBP) has been suggested as a hallmark of demyelination, but how citMBP is implicated in prion diseases remains unknown. For the first time, we developed mouse monoclonal anti-citMBP IgG1 (clones 1B8, 1H1, and 3C6) and IgM (clone 3G5) antibodies that recognize human citMBP at its R25, R122, and R130 residues and at its C-terminal region (or the corresponding sites in mouse MBP), respectively...
May 3, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28467618/effectiveness-of-xp-endo-finisher-and-xp-endo-finisher-r-in-removing-root-filling-remnants-a-micro-ct-study
#14
E J N L Silva, F G Belladonna, A S Zuolo, E Rodrigues, I C Ehrhardt, E M Souza, G De-Deus
AIM: To evaluate the efficacy of filling material removal from oval-shaped canals after the use of supplementary files (XP-endo Finisher and XP-endo Finisher R) through micro-computed tomographic (micro-CT) analysis. METHODOLOGY: The root canals of twenty maxillary single-rooted teeth were prepared with Reciproc R25 files and filled with gutta-percha and AH Plus sealer using the continuous wave of condensation technique. The root canals were then retreated using Reciproc R25 and R40 instruments...
May 3, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28343932/fracture-incidence-of-waveone-and-reciproc-files-during-root-canal-preparation-of-up-to-3-posterior-teeth-a-prospective-clinical-study
#15
Clóvis Stephano Pereira Bueno, Daniel Pinto de Oliveira, Rina Andrea Pelegrine, Carlos Eduardo Fontana, Daniel Guimarães Pedro Rocha, Carlos Eduardo da Silveira Bueno
INTRODUCTION: Reciprocating instruments were developed to improve and simplify the preparation of the root canal system by allowing greater centralization of the canal and requiring a shorter learning curve. Despite the risk of instrument separation, using a reciprocating instrument in more than 1 case is a relatively common clinical practice. The aim of this study was to evaluate the fracture resistance of Reciproc (R25; VDW, Munich, Germany) and WaveOne (Primary; Dentsply Maillefer, Ballaigues, Switzerland) instruments according to the number of uses during the preparation of root canals in up to 3 posterior teeth...
March 23, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28315058/improving-egsb-reactor-performance-for-simultaneous-bioenergy-and-organic-acid-production-from-cheese-whey-via-continuous-biological-h2-production
#16
Lucas Rodrigues Ramos, Edson Luiz Silva
OBJECTIVES: To evaluate the influence of hydraulic retention time (HRT) and cheese whey (CW) substrate concentration (15 and 25 g lactose l(-1)) on the performance of EGSB reactors (R15 and R25, respectively) for H2 production. RESULTS: A decrease in the HRT from 8 to 4 h favored the H2 yield and H2 production rate (HPR) in R15, with maximum values of 0.86 ± 0.11 mmol H2 g COD(-1) and 0.23 ± 0.024 l H2 h(-1) l(-1), respectively. H2 production in R25 was also favored at a HRT of 4 h, with maximum yield and HPR values of 0...
March 17, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28292599/shaping-ability-of-reciproc-waveone-gold-and-hyflex-edm-single-file-systems-in-simulated-s-shaped-canals
#17
Taha Özyürek, Koray Yılmaz, Gülşah Uslu
INTRODUCTION: The aim of the present study was to compare the shaping ability of Reciproc (RPC; VDW, Munich, Germany), HyFlex EDM (HEDM; Coltene/Whaledent AG, Altstätten, Switzerland), and WaveOne GOLD (WOG; Dentsply Maillefer, Ballaigues, Switzerland) nickel-titanium (NiTi) files made of different NiTi alloys in S-shaped simulated canals. METHODS: Sixty S-shaped canals in resin blocks were prepared to an apical size of 0.25 mm using RPC R25, WOG Primary, and HEDM OneFile (n = 20 canal/per group) systems...
March 11, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28258264/flute-and-shank-dimensions-of-reciprocating-instruments-before-and-after-simulated-root-canal-shaping
#18
Felipe C Sampaio, Ana Pp Brito, Heloisa Hp Veloso, Ana Hg de Alencar, Daniel de A Decurcio, José Ap de Figueiredo, Carlos Estrela
AIM: This study analyzed the effect of the dimensions of the flute and shank in the first 4 mm of instrument tips on the deformation and dimensional changes of reciprocating instruments after root canal shaping (RCS). MATERIALS AND METHODS: The reciprocating instruments used were Reciproc(®) R25, R40, and R50; WaveOne(®) Small, Primary, and Large; and Unicone(®) #20, #25, and #40. Scanning electron microscopy images of the first 4 mm of the tip were acquired at 30× magnification before and after simulated curved root canals were shaped...
March 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28243300/comparison-of-apical-extrusion-of-debris-by-using-single-file-full-sequence-rotary-and-reciprocating-systems
#19
Maryam Ehsani, Robab Farhang, Azadeh Harandi, Saeid Tavanafar, Maryam Raoof, Saeedeh Galledar
OBJECTIVES: During root canal preparation, apical extrusion of debris can cause inflammation, flare-ups, and delayed healing. Therefore, instrumentation techniques that cause the least extrusion of debris are desirable. This study aimed to compare apical extrusion of debris by five single-file, full-sequence rotary and reciprocating systems. MATERIALS AND METHODS: One hundred twenty human mandibular premolars with similar root lengths, apical diameters, and canal curvatures were selected and randomly assigned to six groups (n=20): Reciproc R25 (25, 0...
November 2016: Journal of Dentistry of Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/28215345/presence-of-voids-after-continuous-wave-of-condensation-and-single-cone-obturation-in-mandibular-molars-a-micro-computed-tomography-analysis
#20
Elaine Faga Iglecias, Laila Gonzales Freire, George Táccio de Miranda Candeiro, Marcelo Dos Santos, João Humberto Antoniazzi, Giulio Gavini
INTRODUCTION: The objective of this study was to assess the presence of voids in mesial root canals of mandibular molar teeth obturated by using the single-cone (SC) and continuous wave of condensation (CWC) obturation techniques, and results were analyzed by using micro-computed tomography. METHODS: Twenty-four mandibular molars with fully developed roots and mesial root curvature ranging from 25° to 35° were instrumented by using Reciproc R25 files, and then they were obturated by using the SC and CWC techniques...
April 2017: Journal of Endodontics
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