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Translational Psychiatry

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https://www.readbyqxmd.com/read/27927173/reliability-validity-and-factorial-structure-of-the-arabic-version-of-the-international-suicide-prevention-trial-intersept-scale-for-suicidal-thinking-in-schizophrenia-patients-in-doha-qatar
#1
Samer Hammoudeh, Suhaila Ghuloum, Ziyad Mahfoud, Mark Opler, Anzalee Khan, Arij Yehya, Abdulmoneim Abdulhakam, Azza Al-Mujalli, Yahya Hani, Reem Elsherbiny, Hassen Al-Amin
BACKGROUND: Patients with schizophrenia are known to have higher rates of mortality and morbidity when compared to the general population. Suicidality is a major contributor to increased mortality. The International Suicide Prevention Trial (InterSePT) Scale for Suicidal Thinking (ISST) is a validated tool to assess current suicidal ideation in patients with schizophrenia. The aims of the study were to culturally adapt the Arabic translation of ISST and to examine the psychometric characteristics of the Arabic version of the ISST among patients with schizophrenia in Qatar...
December 7, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27895323/elevated-cyp2c19-expression-is-associated-with-depressive-symptoms-and-hippocampal-homeostasis-impairment
#2
M M Jukić, N Opel, J Ström, T Carrillo-Roa, S Miksys, M Novalen, A Renblom, S C Sim, E M Peñas-Lledó, P Courtet, A Llerena, B T Baune, D J de Quervain, A Papassotiropoulos, R F Tyndale, E B Binder, U Dannlowski, M Ingelman-Sundberg
The polymorphic CYP2C19 enzyme metabolizes psychoactive compounds and is expressed in the adult liver and fetal brain. Previously, we demonstrated that the absence of CYP2C19 is associated with lower levels of depressive symptoms in 1472 Swedes. Conversely, transgenic mice carrying the human CYP2C19 gene (2C19TG) have shown an anxious phenotype and decrease in hippocampal volume and adult neurogenesis. The aims of this study were to: (1) examine whether the 2C19TG findings could be translated to humans, (2) evaluate the usefulness of the 2C19TG strain as a tool for preclinical screening of new antidepressants and (3) provide an insight into the molecular underpinnings of the 2C19TG phenotype...
November 29, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27878323/assessing-needs-for-psychiatric-treatment-in-prisoners-2-met-and-unmet-need
#3
Sharon Jakobowitz, Paul Bebbington, Nigel McKenzie, Rachel Iveson, Gary Duffield, Mark Kerr, Helen Killaspy
BACKGROUND: In a companion paper, we established high levels of psychiatric morbidity in prisoners (Bebbington et al. Soc Psychiatry Psychiatr Epidemiol, 2016). In the current report, we evaluate how this morbidity translates into specific needs for treatment and the consequent implications for services. Mental health treatment needs and the extent to which they had been met were assessed in a representative sample of prisoners in a male and a female prison in London (Pentonville and Holloway)...
November 22, 2016: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/27856767/suicidal-thinking-and-behaviour-as-of-600-bce-aesop-s-fables
#4
Julian Davis, Tammie T Money, Saxby Pridmore
OBJECTIVE: Psychiatry has ignored history, anthropology, sociology and literature in the search for enlightenment regarding suicide. Our objective was to determine what, if anything, Aesop's fables had to teach us about suicide in around 600 BCE. Aesop's account is around two centuries older than the oldest text (Herodotus: The histories) previously examined by our group. METHOD: We examined two translations of Aesop's fables, seeking accounts fitting the following categories: (1) suicidal thinking, (2) suicidal behaviour without fatal consequences, and (3) suicidal behaviour with fatal consequences...
November 17, 2016: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/27855769/-cognitive-impairment-after-depression-leads-to-disability
#5
Anja Friis Elliott, Morten Dvoracek Hell, Abigail Sheldrick-Michel, Bent Nielsen
Cognitive impairment plays a crucial role in the course of depression and often persists after remission, which leads to considerable socio-occupational disability. In detecting cognitive deficits, the Danish translation of the Screen for Cognitive Impairment in Psychiatry has proven useful. No current pharmacotherapy has been approved for treating cognitive dysfunction in depression, but selective serotonin reuptake inhibitors may have beneficial effects. Cognitive computer training and psychoeducation are promising in the treatment of cognitive impairment associated with depression...
November 7, 2016: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/27833238/screening-for-depression-among-community-dwelling-elders-usefulness-of-the-center-for-epidemiologic-studies-depression-scale
#6
Sebind Kumar, Anisha Nakulan, Sumesh Purushothaman Thoppil, Rejani Parameshwaran Parassery, Shaji Sivaraman Kunnukattil
CONTEXT: Though common, depressive disorders often remain undetected in late life. AIM: To examine the usefulness of Center for Epidemiologic Studies Depression (CES-D) for identifying depression among older people. SETTINGS AND DESIGN: Community resident older people (aged 65 years or more), were evaluated by clinicians trained in psychiatry, as part of a cross-sectional study of late-life depression. Assessments were done in the community...
September 2016: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/27826750/an-international-position-paper-on-mother-infant-perinatal-mental-health-with-guidelines-for-clinical-practice
#7
Ian Brockington, Ruth Butterworth, Nine Glangeaud-Freudenthal
The purpose of this paper is to set out informal, provisional and comprehensive but concise guidelines for mother-infant (perinatal) mental health (psychiatry), as an area of specialisation. It is informal in the sense that the authors are clinicians and researchers from many different nations, who share a common goal and vision, speaking on their own behalf and not with the backing of any authority or society. It is provisional in the expectation that it can be improved by criticism and new research findings...
November 8, 2016: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/27820966/world-health-organization-disability-assessment-schedule-2-0-an-international-systematic-review
#8
Stefano Federici, Marco Bracalenti, Fabio Meloni, Juan V Luciano
PURPOSE: This systematic review examines research and practical applications of the World Health Organization Disability Assessment Schedule (WHODAS 2.0) as a basis for establishing specific criteria for evaluating relevant international scientific literature. The aims were to establish the extent of international dissemination and use of WHODAS 2.0 and analyze psychometric research on its various translations and adaptations. In particular, we wanted to highlight which psychometric features have been investigated, focusing on the factor structure, reliability, and validity of this instrument...
November 7, 2016: Disability and Rehabilitation
https://www.readbyqxmd.com/read/27810706/how-to-measuring-blood-cytokines-in-biological-psychiatry-using-commercially-available-multiplex-immunoassays
#9
Raoul Belzeaux, Marie-Noëlle Lefebvre, Anne Lazzari, Tifenn Le Carpentier, Julia-Lou Consoloni, Xavier Zendjidjian, Mocrane Abbar, Philippe Courtet, Jean Naudin, José Boucraut, Pierre Gressens, Nicolas Glaichenhaus, El Chérif Ibrahim
Cytokines produced by both immune and non-immune cells are likely to play roles in the development and/or progression of psychiatric disorders. Indeed, many investigators have compared the blood cytokine levels in psychiatric patients with those of healthy controls or monitored their levels in patients during disease progression to identify biomarkers. Nevertheless, very few studies have confirmed that such cytokines remain stable in healthy individuals through periods of weeks and months. This is an important issue to consider before using blood cytokine levels as biomarkers of disease traits, disease state, or treatment response...
January 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27806491/the-validity-and-reliability-of-persian-version-of-wijma-delivery-expectancy-experience-questionnaire-version-a-among-iranian-nulliparous-women
#10
Parvin Abedi, Najva Hazeghi, Poorandokht Afshari, Ahmad Fakhri
Extreme fear of childbirth may interfere with normal process of labor and increase the rate of cesarean section. The aim of this study was to evaluate validity and reliability of a Persian version of Wijma Delivery Expectancy/Experience Questionnaire (W-DEQ) among nulliparous women. In this cross-sectional study, 200 nulliparous women of reproductive age were recruited. The original form of the W-DEQ was received from corresponding author (Garthus-Niegel). This questionnaire was translated into Persian language and back-translated to English by three experts in reproductive health and psychiatry who were fluent in Persian and English...
July 27, 2016: Global Journal of Health Science
https://www.readbyqxmd.com/read/27788673/immuno-psychiatry-an-agenda-for-clinical-practice-and-innovative-research
#11
EDITORIAL
Marion Leboyer, Michael Berk, Robert H Yolken, Ryad Tamouza, David Kupfer, Laurent Groc
BACKGROUND: The diagnostic scheme for psychiatric disorders is currently based purely on descriptive nomenclature given that biomarkers subtypes and clearly defined causal mechanisms are lacking for the vast majority of disorders. The emerging field of "immuno-psychiatry" has the potential to widen the exploration of a mechanism-based nosology, possibly leading to the discovery of more effective personalised treatment strategies. DISCUSSION: Disturbances in immuno-inflammatory and related systems have been implicated in the aetiology, pathophysiology, phenomenology and comorbidity of several psychiatric disorders, including major mood disorders and schizophrenia...
October 28, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27786187/translating-genome-wide-association-findings-into-new-therapeutics-for-psychiatry
#12
Gerome Breen, Qingqin Li, Bryan L Roth, Patricio O'Donnell, Michael Didriksen, Ricardo Dolmetsch, Paul F O'Reilly, Héléna A Gaspar, Husseini Manji, Christopher Huebel, John R Kelsoe, Dheeraj Malhotra, Alessandro Bertolino, Danielle Posthuma, Pamela Sklar, Shitij Kapur, Patrick F Sullivan, David A Collier, Howard J Edenberg
Genome-wide association studies (GWAS) in psychiatry, once they reach sufficient sample size and power, have been enormously successful. The Psychiatric Genomics Consortium (PGC) aims for mega-analyses with sample sizes that will grow to >1 million individuals in the next 5 years. This should lead to hundreds of new findings for common genetic variants across nine psychiatric disorders studied by the PGC. The new targets discovered by GWAS have the potential to restart largely stalled psychiatric drug development pipelines, and the translation of GWAS findings into the clinic is a key aim of the recently funded phase 3 of the PGC...
October 26, 2016: Nature Neuroscience
https://www.readbyqxmd.com/read/27786179/the-road-to-precision-psychiatry-translating-genetics-into-disease-mechanisms
#13
REVIEW
Michael J Gandal, Virpi Leppa, Hyejung Won, Neelroop N Parikshak, Daniel H Geschwind
Hundreds of genetic loci increasing risk for neuropsychiatric disorders have recently been identified. This success, perhaps paradoxically, has posed challenges for therapeutic development, which are amplified by the highly polygenic and pleiotropic nature of these genetic contributions. Success requires understanding the biological impact of single genetic variants and predicting their effects within an individual. Comprehensive functional genomic annotation of risk loci provides a framework for interpretation of neurobiological impact, requiring experimental validation with in vivo or in vitro model systems...
October 26, 2016: Nature Neuroscience
https://www.readbyqxmd.com/read/27786177/on-being-a-circuit-psychiatrist
#14
Joshua A Gordon
At this unique and exciting time for psychiatry, novel therapies for individuals with mental illnesses seem just around the corner. In particular, recent technological advancements in the study of neural circuits provide reasons to be optimistic that the field is headed in the right direction. Nonetheless, maximizing the chances of translating these advancements into real improvements in patient care requires a carefully considered road map.
October 26, 2016: Nature Neuroscience
https://www.readbyqxmd.com/read/27779627/a-support-vector-machine-model-provides-an-accurate-transcript-level-based-diagnostic-for-major-depressive-disorder
#15
J S Yu, A Y Xue, E E Redei, N Bagheri
Major depressive disorder (MDD) is a critical cause of morbidity and disability with an economic cost of hundreds of billions of dollars each year, necessitating more effective treatment strategies and novel approaches to translational research. A notable barrier in addressing this public health threat involves reliable identification of the disorder, as many affected individuals remain undiagnosed or misdiagnosed. An objective blood-based diagnostic test using transcript levels of a panel of markers would provide an invaluable tool for MDD as the infrastructure-including equipment, trained personnel, billing, and governmental approval-for similar tests is well established in clinics worldwide...
October 25, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27775492/dsm-5-turkish-validity-and-reliability-of-dissociative-symptoms-severity-scale-child-form
#16
Şermin Yalın Sapmaz, Dilek Ergin, Nesrin Şen Celasin, Handan Özek Erkuran, Duygu Karaarslan, Siğnem Öztekin, Bengisu Uzel Tanrıverdi, Ertuğrul Köroğlu, Ömer Aydemir
The goal of this study was to assess the validity and reliability of the Turkish version of the DSM-5 Dissociative Symptoms Severity Scale-Child Form. The scale was prepared by translating and then back translating the DSM-5 Dissociative Symptoms Severity Scale. The study groups included one group of 30 patients diagnosed with posttraumatic stress disorder who were treated in a child and adolescent psychiatry unit and a second group of 83 healthy volunteers from middle and high schools in the community. For assessment, the Adolescent Dissociative Experiences Scale (ADES) was used in addition to the DSM-5 Dissociative Symptoms Severity Scale...
October 24, 2016: Journal of Trauma & Dissociation
https://www.readbyqxmd.com/read/27755933/psychoradiology-the-frontier-of-neuroimaging-in-psychiatry
#17
Su Lui, Xiaohong Joe Zhou, John A Sweeney, Qiyong Gong
Unlike neurologic conditions, such as brain tumors, dementia, and stroke, the neural mechanisms for all psychiatric disorders remain unclear. A large body of research obtained with structural and functional magnetic resonance imaging, positron emission tomography/single photon emission computed tomography, and optical imaging has demonstrated regional and illness-specific brain changes at the onset of psychiatric disorders and in individuals at risk for such disorders. Many studies have shown that psychiatric medications induce specific measurable changes in brain anatomy and function that are related to clinical outcomes...
November 2016: Radiology
https://www.readbyqxmd.com/read/27752081/corticotropin-releasing-factor-overexpression-gives-rise-to-sex-differences-in-alzheimer-s-disease-related-signaling
#18
D A Bangasser, H Dong, J Carroll, Z Plona, H Ding, L Rodriguez, C McKennan, J G Csernansky, S H Seeholzer, R J Valentino
Several neuropsychiatric and neurodegenerative disorders share stress as a risk factor and are more prevalent in women than in men. Corticotropin-releasing factor (CRF) orchestrates the stress response, and excessive CRF is thought to contribute to the pathophysiology of these diseases. We previously found that the CRF1 receptor (CRF1) is sex biased whereby coupling to its GTP-binding protein, Gs, is greater in females, whereas β-arrestin-2 coupling is greater in males. This study used a phosphoproteomic approach in CRF-overexpressing (CRF-OE) mice to test the proof of principle that when CRF is in excess, sex-biased CRF1 coupling translates into divergent cell signaling that is expressed as different brain phosphoprotein profiles...
October 18, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27731837/creating-a-pilot-educational-psychiatry-website-opportunities-barriers-and-next-steps
#19
John Torous, Ryan O'Connor, Jamie Franzen, Caitlin Snow, Robert Boland, Robert Kitts
BACKGROUND: While medical students and residents may be utilizing websites as online learning resources, medical trainees and educators now have the opportunity to create such educational websites and digital tools on their own. However, the process and theory of building educational websites for medical education have not yet been fully explored. OBJECTIVE: To understand the opportunities, barriers, and process of creating a novel medical educational website. METHODS: We created a pilot psychiatric educational website to better understand the options, opportunities, challenges, and processes involved in the creation of a psychiatric educational website...
November 5, 2015: JMIR Medical Education
https://www.readbyqxmd.com/read/27686067/what-are-the-barriers-to-access-to-mental-healthcare-and-the-primary-needs-of-asylum-seekers-a-survey-of-mental-health-caregivers-and-primary-care-workers
#20
Javier Bartolomei, Rachel Baeriswyl-Cottin, David Framorando, Filip Kasina, Natacha Premand, Ariel Eytan, Yasser Khazaal
BACKGROUND: We aimed to assess the opinion of primary care workers, social workers, translators and mental health caregivers who work with asylum seekers about the latter's unmet needs and barriers to access to mental healthcare. METHODS: We used a Likert scale to assess the opinion of 135 primary care workers (general practitioners, nurses, social workers and translators) and mental health caregivers about the proportion of asylum seekers with psychiatric disorders, their priority needs and their main barriers to mental health services...
September 29, 2016: BMC Psychiatry
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