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Translational Psychiatry

Su Lui, Xiaohong Joe Zhou, John A Sweeney, Qiyong Gong
Unlike neurologic conditions, such as brain tumors, dementia, and stroke, the neural mechanisms for all psychiatric disorders remain unclear. A large body of research obtained with structural and functional magnetic resonance imaging, positron emission tomography/single photon emission computed tomography, and optical imaging has demonstrated regional and illness-specific brain changes at the onset of psychiatric disorders and in individuals at risk for such disorders. Many studies have shown that psychiatric medications induce specific measurable changes in brain anatomy and function that are related to clinical outcomes...
November 2016: Radiology
D A Bangasser, H Dong, J Carroll, Z Plona, H Ding, L Rodriguez, C McKennan, J G Csernansky, S H Seeholzer, R J Valentino
Several neuropsychiatric and neurodegenerative disorders share stress as a risk factor and are more prevalent in women than in men. Corticotropin-releasing factor (CRF) orchestrates the stress response, and excessive CRF is thought to contribute to the pathophysiology of these diseases. We previously found that the CRF1 receptor (CRF1) is sex biased whereby coupling to its GTP-binding protein, Gs, is greater in females, whereas β-arrestin-2 coupling is greater in males. This study used a phosphoproteomic approach in CRF-overexpressing (CRF-OE) mice to test the proof of principle that when CRF is in excess, sex-biased CRF1 coupling translates into divergent cell signaling that is expressed as different brain phosphoprotein profiles...
October 18, 2016: Molecular Psychiatry
John Torous, Ryan O'Connor, Jamie Franzen, Caitlin Snow, Robert Boland, Robert Kitts
BACKGROUND: While medical students and residents may be utilizing websites as online learning resources, medical trainees and educators now have the opportunity to create such educational websites and digital tools on their own. However, the process and theory of building educational websites for medical education have not yet been fully explored. OBJECTIVE: To understand the opportunities, barriers, and process of creating a novel medical educational website. METHODS: We created a pilot psychiatric educational website to better understand the options, opportunities, challenges, and processes involved in the creation of a psychiatric educational website...
November 5, 2015: JMIR Med Educ
Javier Bartolomei, Rachel Baeriswyl-Cottin, David Framorando, Filip Kasina, Natacha Premand, Ariel Eytan, Yasser Khazaal
BACKGROUND: We aimed to assess the opinion of primary care workers, social workers, translators and mental health caregivers who work with asylum seekers about the latter's unmet needs and barriers to access to mental healthcare. METHODS: We used a Likert scale to assess the opinion of 135 primary care workers (general practitioners, nurses, social workers and translators) and mental health caregivers about the proportion of asylum seekers with psychiatric disorders, their priority needs and their main barriers to mental health services...
September 29, 2016: BMC Psychiatry
J Stedehouder, S A Kushner
Schizophrenia is a debilitating psychiatric disorder characterized by positive, negative and cognitive symptoms. Despite more than a century of research, the neurobiological mechanism underlying schizophrenia remains elusive. White matter abnormalities and interneuron dysfunction are the most widely replicated cellular neuropathological alterations in patients with schizophrenia. However, a unifying model incorporating these findings has not yet been established. Here, we propose that myelination of fast-spiking parvalbumin (PV) interneurons could be an important locus of pathophysiological convergence in schizophrenia...
September 20, 2016: Molecular Psychiatry
E Mahmoudi, M J Cairns
MicroRNAs (miRNAs) represent an important class of small regulatory RNAs that control gene expression posttranscriptionally by targeting mRNAs for degradation or translation inhibition. Early studies have revealed a complex role for miRNAs in major biological processes such as development, differentiation, growth and metabolism. MiR-137 in particular, has been of great interest due to its critical role in brain function and putative involvement in the etiology of both neuropsychiatric disorders and cancer. Several lines of evidence suggest that development, differentiation and maturation of the nervous system is strongly linked to the expression of miR-137 and its regulation of a large number of downstream target genes in various pathways...
September 13, 2016: Molecular Psychiatry
Golan Shahar
An integrative-psychodynamic theory of criticism in self and relationships is presented (Shahar, 2015). My theoretical starting point is the tension between Authenticity (A; our inherited potential, tantamount to Winnicott's True Self) and Self-Knowledge (SK; what we [think] we know about ourselves). Self-criticism, a formidable dimension of vulnerability to a wide array of psychopathologies, is construed as a distorted form of self-knowledge, reducing internal confusion at the expense of widening the gap between A and SK...
2016: Psychodynamic Psychiatry
Eleonora Canciani, Daniela Spotti, Loris Bonetti
AIM: Moral distress (MD) is a painful feeling and/or psychological disequilibrium, which may lead to negative consequences into the wellness of a nurse's working life. Nurses who work in psychiatry are more likely to experience a different type of MD compared with nurses of other contexts. In Italy a tool to evaluate MD in nurses who work in psychiatry doesn't exist. The aim of this study is to validate the Moral Distress Scale for Psychiatric Nurses (MDS-P) in Italian language. METHOD: For translation the forward and back-translation has been used; the effectiveness regarding content and face validity of the translated scale has been analyzed through a focus group with experts of the field...
April 2016: Professioni Infermieristiche
(no author information available yet)
UNLABELLED: Patten SB, Williams JVA, Lavorato DH, et al. Perceived stigma among recipients of mental health care in the general Canadian population. Can J Psychiatry. 2016;61(8): 480-488. (Original DOI: 10.1177/0706743716639928)The published French translation of the above article's abstract was incorrect. The original English abstract for the above article and the correct French translation are provided below: OBJECTIVES: The Mental Health Experiences Scale is a measure of perceived stigma, the perception of negative attitudes and behaviours by people with mental disorders...
October 2016: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
Chi-Ming Leung, Gabor S Ungvari, Yu-Tao Xiang
The paper examines the problems of the existing nomenclature in Chinese psychiatry with special reference to the Chinese translation of bipolar disorder in the context of stigma of mental illness in the Chinese culture. The development of the concept of bipolar disorder is reviewed, followed by a critical examination of the accuracy and validity of the current translation of bipolar disorder in the Chinese psychiatric literature. A new translation is suggested with consideration for literal accuracy and social acceptance...
August 24, 2016: Asia-Pacific Psychiatry: Official Journal of the Pacific Rim College of Psychiatrists
Emily Mendenhall, Kristin Yarris, Brandon A Kohrt
In the past decade anthropologists working the boundary of culture, medicine, and psychiatry have drawn from ethnographic and epidemiological methods to interdigitate data and provide more depth in understanding critical health problems. But rarely do these studies incorporate psychiatric inventories with ethnographic analysis. This article shows how triangulation of research methods strengthens scholars' ability (1) to draw conclusions from smaller data sets and facilitate comparisons of what suffering means across contexts; (2) to unpack the complexities of ethnographic and narrative data by way of interdigitating narratives with standardized evaluations of psychological distress; and (3) to enhance the translatability of narrative data to interventionists and to make anthropological research more accessible to policymakers...
August 23, 2016: Culture, Medicine and Psychiatry
Joanes Grandjean, Damiano Azzinnari, Aline Seuwen, Hannes Sigrist, Erich Seifritz, Christopher R Pryce, Markus Rudin
Human depression, for which chronic psychosocial stress is a major risk factor, is characterized by consistent alterations in neurocircuitry. For example, there is increased functional connectivity (FC) within and between regions comprising the default mode network (DMN) including prefrontal cortex and cingulate cortex. Alterations in network FC are associated with specific aspects of psychopathology. In mice, chronic psychosocial stress (CPS) leads to depression-relevant behavior, including increased fear learning, learned helplessness, fatigue and decreased motivation for reward...
August 9, 2016: NeuroImage
Patrick A Forcelli, Jacqueline T DesJardin, Elizabeth A West, Angela L Holmes, Catherine Elorette, Laurie L Wellman, Ludise Malkova
Brain circuitry underlying defensive behaviors includes forebrain modulatory sites, e.g., the amygdala and hypothalamus, and midbrain effector regions, such as the deep/intermediate layers of the superior colliculus (DLSC). When disinhibited, this network biases behavior towards reflexive defense reactions. While well characterized in rodent models, little is known about this system in the primate brain. Employing focal pharmacological manipulations, we have previously shown that activation of the DLSC triggers reflexive defensive responses, including cowering, escape behaviors, and defensive vocalizations...
August 10, 2016: Social Cognitive and Affective Neuroscience
Sahib S Khalsa, Rachel C Lapidus
Disrupted interoception is a prominent feature of the diagnostic classification of several psychiatric disorders. However, progress in understanding the interoceptive basis of these disorders has been incremental, and the application of interoception in clinical treatment is currently limited to panic disorder. To examine the degree to which the scientific community has recognized interoception as a construct of interest, we identified and individually screened all articles published in the English language on interoception and associated root terms in Pubmed, Psychinfo, and ISI Web of Knowledge...
2016: Frontiers in Psychiatry
(no author information available yet)
In an interview with Neuron, Kerry Ressler discusses key questions in translational psychiatry, enthusiastically recounts a "eureka" moment he had as a student, and shares what he wishes the public understood about psychiatry and science.
July 20, 2016: Neuron
Scott O Lilienfeld, Steven Jay Lynn
One can find psychological authors in the most unexpected places. We present a capsule summary of scholarly publications of psychological interest authored or coauthored by 78 surprising individuals, most of whom are celebrities or relatives of celebrities, historical figures, or people who have otherwise achieved visibility in academic circles, politics, religion, art, and diverse realms of popular culture. Still other publications are authored by individuals who are far better known for their contributions to popular than to academic psychology...
July 2016: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
Gerard R Dawson
The use of experimental medicine studies to bridge the gap between Phase 1 and 2 drug trials and so to enhance translation of basic neuroscience studies using experimental animals to the clinic is proposed. Illustrative examples are provided for affective disorders and schizophrenia in relation also to cognitive dysfunction.
2016: Current Topics in Behavioral Neurosciences
Valerie Voon, Jeffrey W Dalley
Impulsivity and compulsivity have emerged as important dimensional constructs that challenge traditional psychiatric classification systems. Both are present in normal healthy populations where the need to act quickly and repeatedly without hesitation can be highly advantageous. However, when excessively expressed, impulsive and compulsive behavior can lead to adverse consequences and spectrum disorders exemplified by attention-deficit/hyperactivity disorder (ADHD), obsessive compulsive disorder (OCD), autism, and drug addiction...
2016: Current Topics in Behavioral Neurosciences
J D Blom, F R E Smink, E V Kwidama, V M Vladár Rivero
BACKGROUND: A frequent complaint in psychiatry is that the psychiatrist-patient relationship and the quality of care are hampered by bureaucratic processes. AIM: To provide an analysis of various types of bureaucracy in psychiatry that can serve as a starting-point for the improvement of care and the performance of qualitative studies. METHOD: We conducted an exploratory study using PubMed, Google, and various Dutch medical journals. RESULTS: Contemporary psychiatry is characterised by a bureaucratic organization structure...
2016: Tijdschrift Voor Psychiatrie
D Fraguas, C M Díaz-Caneja, M W State, M C O'Donovan, R E Gur, C Arango
Personalized or precision medicine is predicated on the assumption that the average response to treatment is not necessarily representative of the response of each individual. A commitment to personalized medicine demands an effort to bring evidence-based medicine and personalized medicine closer together. The use of relatively homogeneous groups, defined using a priori criteria, may constitute a promising initial step for developing more accurate risk-prediction models with which to advance the development of personalized evidence-based medicine approaches to heterogeneous syndromes such as schizophrenia...
June 23, 2016: Psychological Medicine
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