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https://www.readbyqxmd.com/read/28342837/-malignant-cutaneous-adnexal-neoplasms-of-the-face-and-scalp-diagnostic-and-therapeutic-update
#1
M Romeu, J M Foletti, C Chossegros, J P Dales, P Berbis, B Cribier, L Guyot
INTRODUCTION: Malignant cutaneous adnexal neoplasms are rare and have been characterized only recently. They can occur at any age but preferentially in elderly. There are 3 of them: trichoblastic carcinoma, trichilemmal carcinoma and malignant pilomatricoma. The aim of our study was to make a diagnostic and therapeutic update about these tumors when located at the face or at the scalp. MATERIALS AND METHODS: A bibliographic research was made on PubMed using following keywords: appendage skin carcinoma AND pathology AND/OR therapeutic...
March 22, 2017: J Stomatol Oral Maxillofac Surg
https://www.readbyqxmd.com/read/28339844/intensity-modulated-radiotherapy-using-two-static-ports-of-tomotherapy-for-breast-cancer-after-conservative-surgery-dosimetric-comparison-with-other-treatment-methods-and-3-year-clinical-results
#2
Aiko Nagai, Yuta Shibamoto, Masanori Yoshida, Koji Inoda, Yuzo Kikuchi
This study investigated the differences in dose-volume parameters for the breast and normal tissues during TomoDirectTM (TD) intensity-modulated radiation therapy (IMRT), TD-3D conformal radiotherapy (3DCRT) and 3DCRT plans, all using two beams, and analyzed treatment outcomes of two-beam TD-IMRT for breast cancer after breast-conserving surgery. Between August 2011 and January 2015, 152 patients were treated using two-beam TD-IMRT with 50 Gy/25 fractions. Among them, 20 patients with left-sided breast cancer were randomly chosen, and two-beam TD-IMRT, TD-3DCRT and 3DCRT plans were created for each patient...
February 23, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28336806/fluorouracil-enhances-photodynamic-therapy-of-squamous-cell-carcinoma-via-a-p53-independent-mechanism-that-increases-protoporphyrin-ix-levels-and-tumor-cell-death
#3
Sanjay Anand, Kishore R Rollakanti, Niokelta Brankov, Douglas E Brash, Tayyaba Hasan, Edward V Maytin
Photodynamic therapy (PDT), using 5-aminolevulinic acid (ALA) to drive synthesis of protoporphryin IX (PpIX) is a promising, scar-free alternative to surgery for skin cancers, including squamous cell carcinoma (SCC) and SCC precursors called actinic keratoses (AK). In the United States, PDT is only FDA approved for treatment of AK; this narrow range of indications could be broadened if PDT efficacy were improved. Toward that goal, we developed a mechanism-based combination approach using 5-fluorouracil (5-FU) as a neoadjuvant for ALA-based PDT...
March 23, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28336245/does-the-timing-of-chemotherapy-affect-post-mastectomy-breast-reconstruction-complications
#4
Oriana Cohen, Gretl Lam, Mihye Choi, Nolan Karp, Daniel Ceradini
INTRODUCTION: In this study we evaluated how the timing of chemotherapy for breast cancer affects post-reconstruction complications to determine whether there is an optimal time for breast reconstruction after chemotherapy. PATIENTS AND METHODS: A retrospective review identified 344 breast cancer patients who underwent chemotherapy with mastectomy and autologous/prosthetic reconstruction from 2011 to 2014. A control group of 127 breast cancer patients who underwent mastectomy and autologous/prosthetic reconstruction without chemotherapy was also identified from the same period...
February 17, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28331735/metaplastic-breast-carcinoma-analysis-of-clinical-and-pathologic-characteristics-a-case-series
#5
Semra Salimoğlu, İsmail Sert, Mustafa Emiroğlu, Cem Karaali, Dilek Kuzukıran, Yasemin Akyüz Kırmızı, Gülden Diniz, Cengiz Aydın
OBJECTIVE: Metaplastic breast cancer (MBC) is a rare type of breast cancer that is considered to be clinically aggressive. The clinical significance and prognostic risk factors of MBC are limited. This study comprises a retrospective analysis of the clinical and pathologic findings of a series of patients treated for MBC. MATERIALS AND METHODS: The files of 657 patients who underwent surgery because of breast cancer at our clinic were examined and the data found on 11 patients who were diagnosed as having MBC were analyzed...
April 2016: J Breast Health (2013)
https://www.readbyqxmd.com/read/28329662/the-preneoplastic-genome-transcriptomic-drivers-of-squamous-cell-carcinoma-development
#6
Kenneth Y Tsai
Cutaneous squamous cell carcinoma (cuSCC) comprises 15-20% of all skin cancers, accounting for over 700,000 cases in the U.S. annually. Most cuSCC arise in association with a distinct precancerous lesion, the actinic keratosis (AK). In order to identify potential targets for molecularly targeted chemoprevention, we performed integrated cross-species genomic analysis of cuSCC development through the preneoplastic AK stage using matched human samples and a solar UV- driven Hairless mouse model. We performed RNA-seq and microRNA-seq on samples from both patients undergoing Mohs surgery and the mouse model...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28328703/functionality-of-patients-75-years-and-older-undergoing-mohs-micrographic-surgery-a-multicenter-study
#7
Christie G Regula, Murad Alam, Ramona Behshad, Marc Glashofer, C William Hanke, Christopher Harmon, Ryan Johnson, David Kent, Patrick Lee, Naomi Lawrence
BACKGROUND: Mohs surgery is indisputably a highly effective treatment for nonmelanoma skin cancers. In the current health care environment, physicians are challenged to provide high quality, efficacious care in a manner that is mindful of the patient's general health and well-being. We have used a functional assessment to evaluate older patients who present for Mohs surgery. OBJECTIVE: The purpose of this study is to categorize the functional status, using the Karnofsky Performance Status (KPS) Scale, of patients 75 years and older undergoing Mohs surgery of a nonmelanoma skin cancer and to identify distinguishing characteristics of lower functioning patients...
March 21, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28327615/neoadjuvant-chemotherapy-creates-surgery-opportunities-for-inoperable-locally-advanced-breast-cancer
#8
Minghao Wang, Lingmi Hou, Maoshan Chen, Yan Zhou, Yueyang Liang, Shushu Wang, Jun Jiang, Yi Zhang
Neoadjuvant chemotherapy (NAC), the systematic chemotherapy given to patients with locally advanced and inoperable breast caner, has been proven to be of great clinical values. Many scientific reports confirmed NAC could effectively eliminate sub-clinical disseminated lesions of tumor, and improve long-term and disease-free survival rate of patients with locally advanced breast cancer (LABC); however, up to now, LABC is still a serious clinical issue given improved screening and early diagnosis. This study, with main focus on inoperable LABC, investigated the values of NAC in converting inoperable LABC into operable status and assessed the prognosis...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28325565/impact-of-the-method-and-success-of-pharyngeal-reconstruction-on-the-outcome-of-treating-laryngeal-and-hypopharyngeal-cancers-with-pharyngolaryngectomy-a-national-analysis
#9
S A R Nouraei, A Dias, H Kanona, D Vokes, P O'Flynn, P M Clarke, S E Middleton, A Darzi, P Aylin, N Jallali
BACKGROUND: Surgical treatment of cancers that arise from or invade the hypopharynx presents major reconstructive challenges. Reconstructive failure exposes the airway and neck vessels to digestive contents. METHODS: We performed a national N = near-all analysis of the administrative dataset to identify pharyngolaryngectomies in England between 2002 and 2012. Information about morbidity, pharyngeal closure method and post-operative complications was derived. RESULTS: There were 1589 predominantly male (78%) patients whose mean age at surgery was 62 years...
January 9, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28325388/the-role-of-imaging-in-the-management-of-patients-with-nonmelanoma-skin-cancer-diagnostic-modalities-and-applications
#10
REVIEW
Deborah MacFarlane, Komal Shah, Ashley Wysong, Ximena Wortsman, Tatyana R Humphreys
While uncomplicated cases of nonmelanoma skin cancer can be treated with surgery, destruction, or topical therapy alone, advanced or neglected cases require more complex management decisions. Dermatologists and dermatologic surgeons should be familiar with the imaging techniques relevant to cutaneous oncology and their value in different clinical scenarios. Herein we review imaging modalities used in management of nonmelanoma skin cancer.
April 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28319637/online-patient-reported-reviews-of-mohs-micrographic-surgery-qualitative-analysis-of-positive-and-negative-experiences
#11
Shuai Xu, Zaza Atanelov, Ashish C Bhatia
Mohs micrographic surgery (MMS) is the gold standard for treating high-risk skin cancers and skin cancers in areas where skin sparing is essential. However, relatively little is known about patient-reported satisfaction with this procedure. In this study, we used qualitative research methods to determine themes of patient-reported satisfaction and dissatisfaction with MMS on one popular online resource (RealSelf). Real-world patient feedback provides an opportunity for physicians to explore the patient mind-set and to target areas of potential improvement in MMS patient satisfaction...
February 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28314866/a-clinical-trial-using-attrition-combined-with-5-aminolevulinic-acids-based-photodynamic-therapy-in-treating-squamous-cell-carcinoma
#12
Jianzhong Peng, Weiguo Feng, Xianyan Luo, Tao Wang, Wenzhong Xiang, Yeqin Dai, Jingyu Zhu, Junhui Zheng
BACKGROUND Squamous cell carcinoma (SCC) is the second most common type of skin cancer, for which non- or mini-invasive treatment is of critical importance. 5-aminolevulinic acids based photodynamic therapy (ALA-PDT) is a mini-invasive approach that causes focal tumor cell injury, apoptosis, and necrosis through light sensitivity. The efficacy of combining ALA-PDT and surgery in treating SCC, however, has not been demonstrated. MATERIAL AND METHODS A total of 60 SCC patients were randomly assigned into attrition plus ALA-PDT group (experimental group) and single ALA-PDT treatment group (control group)...
March 18, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28295364/melanoma-chemoprevention-current-status-and-future-prospects
#13
Gagan Chhabra, Mary Ann Ndiaye, Liz Mariely Garcia-Peterson, Nihal Ahmad
The incidence of skin cancers, both non-melanoma as well as melanoma, are increasing in the United States. The ultraviolet radiation, mainly from sun, is considered the major cause for these neoplasms. While non-melanoma skin cancers are far more numerous, melanoma remains the most challenging. This is because melanoma can become extremely aggressive and its incidence is increasing worldwide due to lack of effective early detection, as well as disease recurrence, following both surgery and chemotherapy. Therefore, in addition to better treatment options, newer means are required to prevent melanomas from developing...
March 15, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28294289/hypofractionated-radiotherapy-in-older-patients-with-non-melanoma-skin-cancer-less-is-better
#14
Michael Veness
Radiotherapy is a non-surgical option for patients with non-melanoma skin cancer. Lesions in middle-aged to older patients with good performance status are typically prescribed 4-5 weeks of outpatient weekday treatment. Daily radiotherapy fraction sizes of 2-3 Gy are recommended to decrease the late cutaneous consequences such as in-field hypopigmentation and telangiectasia. In elderly, often unwell patients, these concerns are less of an issue and larger fraction sizes (5-7 Gy), referred to as hypofractionation, can be delivered over a shorter time yet still achieve excellent in-field control and improve a patient's quality of life and avoid the need for surgery...
March 9, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28293723/continuous-wound-infiltration-system-for-postoperative-pain-management-in-gynecologic-oncology-patients
#15
Banghyun Lee, Kidong Kim, Soyeon Ahn, Hyun-Jung Shin, Dong Hoon Suh, Jae Hong No, Yong Beom Kim
PURPOSE: Major open surgery for gynecologic cancer usually involves a long midline skin incision and induces severe postoperative surgical site pain (POSP) that may not be effectively controlled with the conventional management. We investigated whether combining a continuous wound infiltration system (CWIS, ON-Q PainBuster(®)) and intravenous patient-controlled analgesia (IV PCA) effectively decreases POSP, compared with IV PCA alone, in gynecologic oncology patients. METHODS: This retrospective study included 62 Korean patients who received a long midline skin incision during gynecologic cancer surgery...
March 14, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28292663/ileal-strangulation-by-a-secondary-perineal-hernia-after-laparoscopic-abdominoperineal-rectal-resection-a-case-report
#16
Kurokawa Tomohiro, Giichiro Tsurita, Kentaro Yazawa, Masaru Shinozaki
INTRODUCITON: We report a recent case of strangulated bowel obstruction due to an incarcerated secondary perineal hernia that developed after laparoscopic rectal resection. PRESENTATION OF CASE: A 75-year-old man undergoing treatment for alcoholic cirrhosis underwent laparoscopic abdominoperineal resection of the rectum (APR) for lower rectal cancer after preoperative chemoradiotherapy. Lung metastases were diagnosed 2 months postoperatively. Ten days after chemotherapy initiation, the patient was hospitalized on an emergency basis due to hepatic encephalopathy...
February 12, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28292569/indocyanine-green-applications-in-plastic-surgery-a-review-of-the-literature
#17
Pierre Burnier, Jérémy Niddam, Romain Bosc, Barbara Hersant, Jean-Paul Meningaud
INTRODUCTION: Use of indocyanine green (ICG) near-infrared fluorescence as a dye to assess tissue vascularization is now well standardized. The aim of this literature review was to review and resume the most recent recommendations for ICG use in its plastic surgery applications. METHODS: A systematic literature review was performed using Medline, EMBASE, and PubMed databases to obtain the latest recommendations for ICG in plastic surgery. Inclusion criteria were all articles written in English language that evaluated pre-, intra-, or postoperative ICG applications in surgical procedures usually performed by plastic surgeons...
February 20, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28284233/retrospective-study-of-rare-cutaneous-malignant-adnexal-tumors-of-the-head-and-neck-in-a-tertiary-care-cancer-hospital-a-case-series
#18
Omer Waqas, Muhammad Faisal, Irfan Haider, Awais Amjad, Arif Jamshed, Raza Hussain
BACKGROUND: Adnexal tumors of the skin are a large and diverse group of benign and malignant neoplasms, which exhibit morphological differentiation toward one of the different types of adnexal epithelium present in normal skin and they pose a diagnostic challenge. The purpose of this study is to share our experience with these rare but aggressive tumors at a tertiary care cancer hospital in a developing country. A retrospective review of 11 patients diagnosed with rare adnexal tumors and their variants from January 2005 to December 2014, treated either surgically or non-surgically, was performed to describe the clinicopathological characteristics and outcome of the disease...
March 12, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28282922/the-development-of-a-novel-therapeutic-strategy-to-target-hyaluronan-in-the-extracellular-matrix-of-pancreatic-ductal-adenocarcinoma
#19
REVIEW
Daisuke Kudo, Akiko Suto, Kenichi Hakamada
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal diseases to affect humans, regardless of whether patients receive multimodal therapy (including surgery, radiotherapy, and chemotherapy). This resistance to intervention is currently considered to be caused by the desmoplastic change of the extracellular matrix (ECM) in PDAC tissues, which is characterized by the accumulation of cancer-associated fibroblasts, collagen, proteoglycan, and hyaluronan. Among these ECM components, hyaluronan has attracted interest because various studies have indicated that hyaluronan-rich PDAC is correlated with the progressive properties of cancer cells, both in experimental and clinical settings...
March 9, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28281862/model-based-approach-for-quantitative-estimates-of-skin-heart-and-lung-toxicity-risk-for-left-side-photon-and-proton-irradiation-after-breast-conserving-surgery
#20
Francesco Tommasino, Marco Durante, Vittoria D'Avino, Raffaele Liuzzi, Manuel Conson, Paolo Farace, Giuseppe Palma, Marco Schwarz, Laura Cella, Roberto Pacelli
BACKGROUND: Proton beam therapy represents a promising modality for left-side breast cancer (BC) treatment, but concerns have been raised about skin toxicity and poor cosmesis. The aim of this study is to apply skin normal tissue complication probability (NTCP) model for intensity modulated proton therapy (IMPT) optimization in left-side BC. MATERIAL AND METHODS: Ten left-side BC patients undergoing photon irradiation after breast-conserving surgery were randomly selected from our clinical database...
March 10, 2017: Acta Oncologica
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