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https://www.readbyqxmd.com/read/29215650/phenocopies-in-melanoma-prone-families-with-germ-line-cdkn2a-mutations
#1
Hildur Helgadottir, Håkan Olsson, Margaret A Tucker, Xiaohong R Yang, Veronica Höiom, Alisa M Goldstein
PurposeCarriers of CDKN2A mutations have high risks of melanoma and certain other cancers. In this study we examined the occurrence of tumors among CDKN2A wild type (wt) members of melanoma-prone families with CDKN2A mutations.MethodsSwedish and US melanoma-prone families with CDKN2A mutations were included. Data was collected on tumors diagnosed among family members. Among the CDKN2A mutated families, members with CDKN2A wt status who were diagnosed with melanoma were designated phenocopies.ResultsOf patients with melanoma in the CDKN2A mutated families (n = 266), 7...
December 7, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29199694/retrospective-analysis-of-icotinib-neoadjuvant-therapy-of-63-lung-cancer-patients
#2
T Wang, Y Liu, B Zhou, S Hao, Z Wang, N Liang, J Liu, S Wang
OBJECTIVE: This study aims to explore the feasibility of icotinib neoadjuvant therapy for nonsmall cell lung cancer (NSCLC). MATERIALS AND METHODS: This was a retrospective analysis of the clinical data for 63 NSCLC patients (61 cases of adenocarcinoma and two cases of squamous cell carcinoma) receiving surgical resection of lung lesions after oral intake of icotinib from December 2011 to November 2013 in the PLA General Hospital. Preoperative oral intake of the patients was icotinib 125 mg tid, drug side effects were evaluated according to the American National Cancer Institute Common Toxicity Criteria Version 4...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29179523/management-of-intracranial-melanomas-in-the-era-of-precision-medicine
#3
REVIEW
Grace J Young, Wenya Linda Bi, Winona W Wu, Tanner M Johanns, Gavin P Dunn, Ian F Dunn
Melanoma is the most lethal of skin cancers, in part because of its proclivity for rapid and distant metastasis. It is also potentially the most neurotropic cancer in terms of probability of CNS metastasis from the primary lesion. Despite surgical resection and radiotherapy, prognosis remains guarded for patients with brain metastases. Over the past five years, a new domain of personalized therapy has emerged for advanced melanoma patients with the introduction of BRAF and other MAP kinase pathway inhibitors, immunotherapy, and combinatory therapeutic strategies...
October 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/29154802/microrna-profiling-in-mda-mb-231-human-breast-cancer-cell-exposed-to-the-phaleria-macrocarpa-boerl-fruit-ethyl-acetate-fraction-pmeaf-through-iilumina-hi-seq-technologies-and-various-in-silico-bioinformatics-tools
#4
Nowroji Kavitha, Soundararajan Vijayarathna, Shanmugapriya, Chern Ein Oon, Yeng Chen, Jagat R Kanwar, Vasu Punj, Sreenivasan Sasidharan
ETHNOPHARMACOLOGICAL RELEVANCE: Phaleria macrocarpa (Scheff) Boerl, is a famous traditional medicinal plant which exhibited cytotoxicity against various cancerous cells. Traditionally, P. macrocarpa has been used to control cancer, impotency, hemorrhoids, diabetes mellitus, allergies, liver and heart disease, kidney disorders, blood diseases, acne, stroke, migraine, and various skin diseases. AIM OF THE STUDY: Recent studies have demonstrated a potent anticancer potential of P...
November 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29130769/neuroprotective-effects-and-uplc-q-tof-ms-based-active-components-identification-of-external-applied-a-novel-wen-luo-tong-microemulsion
#5
Hong-Mei Lin, Long-Fei Lin, Zhen-Zhen Xia, Yong Mao, Jia Liu, Ling-Yan Xu, Qing Wu
Chemotherapy induced neuropathy causes excruciating pain to cancer patients. Wen-Luo-Tong (WLT), a traditional Chinese medicinal compound, has been used to alleviate anti-cancer drug such as oxaliplatin-induced neuropathic pain for many years. However, the current route of administration of WLT is inconvenient and the active ingredients and mechanism of action of WLT are still unclear. To address these issues, we developed a novel formulation of WLT (W/O microemulsion) for the ease of application. New ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) methods were employed for analysis of the ingredients...
November 13, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29130352/medicinal-properties-of-alpha-santalol-a-naturally-occurring-constituent-of-sandalwood-oil-review
#6
Ajay Bommareddy, Sarah Brozena, James Steigerwalt, Terra Landis, Sarah Hughes, Erica Mabry, Aaron Knopp, Adam L VanWert, Chandradhar Dwivedi
Alpha-santalol is a naturally occurring sesquiterpene that is derived from sandalwood oil. Its wide range of health benefits have been attributed to the modulation of various signalling pathways involved in the development of a particular disease. For example, the antitumour and cancer preventive properties of alpha-santalol have been shown to involve cell death induction through apoptosis and cell cycle arrest in various cancer models. A marked decrease in inflammatory markers have also been shown with alpha-santalol administration in skin tissue models...
November 13, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29124377/trendy-tattoos-maybe-a-serious-health-risk
#7
Felix J Paprottka, Nicco Krezdorn, Mustafa Narwan, Marvee Turk, Heiko Sorg, Ernst Magnus Noah, Detlev Hebebrand
BACKGROUND: The literature reports many cases of cutaneous malignancy in the setting of skin tattoos. In this study, we review the reported incidence of and risk factors for tattoo-associated skin cancer. METHODS: A PubMed literature review was performed for all cases of tattoo-associated skin cancer, including squamous cell carcinoma, basal cell carcinoma, malignant melanoma, keratoacanthoma, and other rare skin malignancies (source: PubMed/until June 2017). RESULTS: The authors identified 51 publications and 63 total cases of tattoo-associated skin cancer...
November 9, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29123409/preventive-effect-of-kampo-medicine-hangeshashin-to-tj-14-plus-minocycline-against-afatinib-induced-diarrhea-and-skin-rash-in-patients-with-non-small-cell-lung-cancer
#8
Masao Ichiki, Hiroshi Wataya, Kazuhiko Yamada, Nobuko Tsuruta, Hiroaki Takeoka, Yusuke Okayama, Jun Sasaki, Tomoaki Hoshino
Purpose: Diarrhea and oral mucositis induced by afatinib can cause devastating quality of life issues for patients undergoing afatinib treatment. Several studies have shown that hangeshashin-to (TJ-14) might be useful for chemotherapy-induced diarrhea and oral mucositis. In this study, we investigated the prophylactic effects of TJ-14 for afatinib-induced diarrhea and oral mucositis and minocycline for afatinib-induced skin rash. Patients and methods: First- and second-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors have become the standard first-line treatment in patients with EGFR-mutated non-small cell lung cancer...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29098921/black-salve-treatment-of-skin-cancer-a-review
#9
Alvin Lim
The use of complementary and alternative medicines in Australia has grown significantly. Much of this growth is due to their ease of accessibility from online vendors, often marketed with claims that are not scientifically tested. Black salve is a topical escharotic compound containing the active component sanguinarine, derived from the bloodroot plant. It has been advertised as a natural treatment for skin cancer. This article reviews the current state of black salve as an alternative skin cancer treatment, discussing its distribution and regulation, and provides a summary of clinical and laboratory studies...
November 3, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29056081/the-risks-and-benefits-of-cannabis-in-the-dermatology-clinic
#10
Gurbir Dhadwal, Mark G Kirchhof
Cannabis ( Cannabis sativa/indica), also known as marijuana, has been used for medicinal and recreational purposes for millennia. There has been a recent trend to legalize the use of cannabis, as illustrated by the recent legalization votes in numerous states in the United States and legislation in Canada to allow recreational cannabis use. With this increasing consumption of cannabis, dermatologists will see increased pressure to prescribe cannabis and will see the side effects of cannabis use with greater frequency...
October 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28989253/psidium-guajava-a-single-plant-for-multiple-health-problems-of-rural-indian-population
#11
REVIEW
Poonam G Daswani, Manasi S Gholkar, Tannaz J Birdi
The rural population in India faces a number of health problems and often has to rely on local remedies. Psidium guajava Linn. (guava), a tropical plant which is used as food and medicine can be used by rural communities due to its several medicinal properties. A literature search was undertaken to gauge the rural health scenario in India and compile the available literature on guava so as to reflect its usage in the treatment of multiple health conditions prevalent in rural communities. Towards this, electronic databases such as Pubmed, Science Direct, google scholar were scanned...
July 2017: Pharmacognosy Reviews
https://www.readbyqxmd.com/read/28972736/design-and-functionalization-of-the-nir-responsive-photothermal-semiconductor-nanomaterials-for-cancer-theranostics
#12
Xiaojuan Huang, Wenlong Zhang, Guoqiang Guan, Guosheng Song, Rujia Zou, Junqing Hu
Despite the development of medical technology, cancer still remains a great threat to the survival of people all over the world. Photothermal therapy (PTT) is a minimally invasive method for selective photothermal ablation of cancer cells without damages to normal cells. Recently, copper chalcogenide semiconductors have emerged as a promising photothermal agent attributed to strong absorbance in the near-infrared (NIR) region and high photothermal conversion efficiency. An earlier study witnessed a rapid increase in their development for cancer therapy, including CuS, Cu2-xSe and CuTe nanocrystals...
October 3, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28964869/anti-proliferative-and-pro-apoptotic-effects-of-uncaria-tomentosa-aqueous-extract-in-squamous-carcinoma-cells
#13
Francesca Ciani, Simona Tafuri, Annaelena Troiano, Alessio Cimmino, Bianca Saveria Fioretto, Andrea Maria Guarino, Alessandra Pollice, Maria Vivo, Antonio Evidente, Domenico Carotenuto, Viola Calabrò
Uncaria tomentosa (Willd.) DC. (Rubiacee), also known as uña de gato, is a plant that grows wild in the upper Amazon region of Peru and has been widely used in folk medicine to treat several health conditions including cancer. We have produced an aqueous extract from Uncaria tomentosa (UT-ex) and analyzed its effects on squamous carcinoma cells and immortalized HaCaT keratinocytes. Squamous cell carcinoma (SCC) is an uncontrolled growth of abnormal cells arising in the skin's squamous layer of epidermis. When detected at an early stage, SCCs are almost curable, however, if left untreated, they can penetrate the underlying tissue and become disfiguring...
September 28, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28942553/clinacanthus-nutans-mitigates-neuronal-apoptosis-and-ischemic-brain-damage-through-augmenting-the-c-ebp%C3%AE-driven-ppar-%C3%AE-transcription
#14
Jui-Sheng Wu, Mei-Han Kao, Hsin-Da Tsai, Wai-Mui Cheung, Jin-Jer Chen, Wei-Yi Ong, Grace Y Sun, Teng-Nan Lin
Clinacanthus nutans Lindau (C. nutans) is a traditional herbal medicine widely used in Asian countries for treating a number of remedies including snake and insect bites, skin rashes, viral infections, and cancer. However, the underlying molecular mechanisms for its action and whether C. nutans can offer protection on stroke damage in brain remain largely unknown. In the present study, we demonstrated protective effects of C. nutans extract to ameliorate neuronal apoptotic death in the oxygen-glucose deprivation model and to reduce infarction and mitigate functional deficits in the middle cerebral artery occlusion model, either administered before or after hypoxic/ischemic insult...
September 23, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28937580/diagnosis-of-systemic-inflammatory-diseases-among-patients-admitted-for-acute-pericarditis-with-pericardial-effusion
#15
Maureen Assayag, Rachid Abbas, Noémie Chanson, Anne Perozziello, Gregory Ducrocq, Jean-François Alexandra, Antoine Dossier, Thomas Papo, Karim Sacre
AIMS: Acute pericarditis may be the heralding manifestation of various systemic inflammatory diseases (SIDs). The aim of this study was to identify clinical indicators for SIDs in patients admitted for acute pericarditis with pericardial effusion. METHODS: All consecutive adult patients hospitalized in a Department of Internal Medicine over a 10-year period for acute pericarditis with pericardial effusion were retrospectively reviewed. Patients with cancer and tuberculosis were excluded...
November 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28930257/physicochemical-properties-antioxidant-and-cytotoxic-activities-of-crude-extracts-and-fractions-from-phyllanthus-amarus
#16
Van Tang Nguyen, Jennette A Sakoff, Christopher J Scarlett
Background:Phyllanthus amarus (P. amarus) has been used as a medicinal plant for the prevention and treatment of chronic ailments such as diabetes, hepatitis, and cancer. Methods: The physicochemical properties, antioxidant and cytotoxic activities of crude extracts and fractions from P. amarus were determined using spectrophotometric method. Results: The P. amarus methanol (PAM) extract had lower levels of residual moisture (7.40%) and water activity (0.24) and higher contents of saponins, phenolics, flavonoids, and proanthocyanidins (1657...
June 18, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28922731/shikonin-suppresses-pulmonary-fibroblasts-proliferation-and-activation-by-regulating-akt-and-p38-mapk-signaling-pathways
#17
Yunjuan Nie, Yaoyao Yang, Jian Zhang, Guowei Cai, Yanhua Chang, Gaoshang Chai, Chongyong Guo
Fibroblast is believed to be the primary effector in idiopathic pulmonary fibrosis (IPF), a progressive lung disorder characterized by aberrant tissue remodeling and the formation of fibroblastic foci. Due to the complicated etiology and mechanism, there are few effective drugs for this fatal disease. Shikonin (SHI), which is the major ingredient isolated from the plant Lithospermum Erythrorhizon, has long been used as traditional medicine for many diseases including inflammation and cancer. The roles of SHI in attenuating skin scar and renal fibrosis by reducing TGFβ1-stimulated fibroblast activation are also reported...
November 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28915974/rapid-and-accurate-intraoperative-pathological-diagnosis-by-artificial-intelligence-with-deep-learning-technology
#18
Jing Zhang, Yanlin Song, Fan Xia, Chenjing Zhu, Yingying Zhang, Wenpeng Song, Jianguo Xu, Xuelei Ma
Frozen section is widely used for intraoperative pathological diagnosis (IOPD), which is essential for intraoperative decision making. However, frozen section suffers from some drawbacks, such as time consuming and high misdiagnosis rate. Recently, artificial intelligence (AI) with deep learning technology has shown bright future in medicine. We hypothesize that AI with deep learning technology could help IOPD, with a computer trained by a dataset of intraoperative lesion images. Evidences supporting our hypothesis included the successful use of AI with deep learning technology in diagnosing skin cancer, and the developed method of deep-learning algorithm...
September 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28914009/luminescent-diagnostics-of-skin-defects-in-the-near-infrared-range
#19
Yuriy V Alekseev, Valentina D Rumyantseva, Anastasiya S Gorshkova, Anastasiya E Shchelkunova, Igor P Shilov, Andrey V Ivanov
Photodynamic therapy becomes a widely spread method due to cancer growth in the world. However, to detect tumors at early stages, it is necessary to carry out diagnostic measures in a timely manner. Our aim was to test the developed pharmaceutical composition, which can be used for external application in early fluorescent diagnostics even in the absence of visual changes, as well as for therapy effectiveness control. Pharmacokinetic studies on laboratory animals and volunteers were carried out. The results have shown that the dipotassium salt of Yb3+-dimethoxyhematoporphyrin IX, which is highly soluble in water and stable in storage, is a promising marker for earlier diagnostics of tumors and can be used in dermatology, dentistry, gynecology, cosmetology, ear, nose, and throat diseases, veterinary, and in other areas of medicine...
September 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28893230/assessment-of-free-radical-scavenging-and-anti-proliferative-activities-of-tinospora-cordifolia-miers-willd
#20
Picheswara Rao Polu, Udupa Nayanbhirama, Saleemulla Khan, Rajlexmi Maheswari
BACKGROUND: Tinospora cordifolia (Guduchi or Amrita) is an important drug of Ayurvedic System of Medicine and found mention in various classical texts for the treatment of diseases such as jaundice, fever, diabetes, cancer and skin disease etc. In view of its traditional claims, antioxidant and anti-proliferative activities were evaluated in the present study. METHODS: Ethanol extract (TCE) and subsequent petroleum ether (TCP), dichloromethane (TCD), n-Butanol (TCB) and aqueous (TCA) fractions of were prepared from stems of T cordifolia...
September 11, 2017: BMC Complementary and Alternative Medicine
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