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https://www.readbyqxmd.com/read/28335476/inhibition-of-neoplastic-transformation-and-chemically-induced-skin-hyperplasia-in-mice-by-traditional-chinese-medicinal-formula-si-wu-tang
#1
Mandy M Liu, Kevin M Huang, Steven Yeung, Andy Chang, Suhui Zhang, Nan Mei, Cyrus Parsa, Robert Orlando, Ying Huang
Exploring traditional medicines may lead to the development of low-cost and non-toxic cancer preventive agents. Si-Wu-Tang (SWT), comprising the combination of four herbs, Rehmanniae, Angelica, Chuanxiong, and Paeoniae, is one of the most popular traditional Chinese medicines for women's diseases. In our previous studies, the antioxidant Nrf2 pathways were strongly induced by SWT in vitro and in vivo. Since Nrf2 activation has been associated with anticarcinogenic effects, the purpose of this study is to evaluate SWT's activity of cancer prevention...
March 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28330284/in-vitro-evaluation-of-anti-proliferative-anti-inflammatory-and-pro-apoptotic-activities-of-the-methanolic-extracts-of-andrographis-nallamalayana-ellis-on-a375-and-b16f10-melanoma-cell-lines
#2
Guroji Purushotham, Yerukala Padma, Yusuf Nabiha, R R Venkata Raju
Natural plant products have been widely used in controlling cancer with fewer or no side effects and the use of plant extracts as complementary to synthetic medicine is gaining increased popularity. Members of Andrographis plants possess important medicinal properties. In the present study, anti-cancerous properties of Andrographis nallamalayana (AN) were tested on A375 and B16F10 skin melanoma cancer cell lines. The leaf extracts of AN significantly reduced the cell viability and cell survival of skin cancer cell lines, achieved by MTT assay and clonogenic assays, respectively...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28302011/the-pharmacological-mechanisms-and-therapeutic-activities-of-hydroxychloroquine-in-rheumatic-and-related-diseases
#3
Changfeng Hu, Lu Lu, Jie-Ping Wan, Chengping Wen
Hydroxychloroquine (HCQ) is known as one of the most fascinating synthetic antimalarial drugs during the last 50 years. It is currently among the most commonly employed medicines for the clinical treatment of rheumatic diseases, especially systemic lupus erythematosus and rheumatoid arthritis. In related mechanism studies, it has been found that HCQ possesses various immunomodulatory and anti-inflammatory activities. In addition, the effects of HCQ on anti-platelet, metabolic pathways, and antineoplasticity have also been disclosed in more recent studies...
March 16, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28290363/volatile-and-non-volatile-semi-volatile-compounds-and-in-vitro-bioactive-properties-of-chilean-ulmo-eucryphia-cordifolia-cav-honey
#4
Francisca Acevedo, Paulina Torres, B Dave Oomah, Severino Matias de Alencar, Adna Prado Massarioli, Raquel Martín-Venegas, Vicenta Albarral-Ávila, César Burgos-Díaz, Ruth Ferrer, Mónica Rubilar
Ulmo honey originating from Eucryphia cordifolia tree, known locally in the Araucania region as the Ulmo tree is a natural product with valuable nutritional and medicinal qualities. It has been used in the Mapuche culture to treat infections. This study aimed to identify the volatile and non-volatile/semi-volatile compounds of Ulmo honey and elucidate its in vitro biological properties by evaluating its antioxidant, antibacterial, antiproliferative and hemolytic properties and cytotoxicity in Caco-2 cells. Headspace volatiles of Ulmo honey were isolated by solid-phase microextraction (SPME); non-volatiles/semi-volatiles were obtained by removing all saccharides with acidified water and the compounds were identified by GC/MS analysis...
April 2017: Food Research International
https://www.readbyqxmd.com/read/28289382/the-hydrogen-sulfide-releasing-molecule-acetyl-deacylasadisulfide-inhibits-metastatic-melanoma
#5
Paola De Cicco, Elisabetta Panza, Chiara Armogida, Giuseppe Ercolano, Orazio Taglialatela-Scafati, Yalda Shokoohinia, Rosa Camerlingo, Giuseppe Pirozzi, Vincenzo Calderone, Giuseppe Cirino, Angela Ianaro
Melanoma is the most common form of skin cancer. Given its high mortality, the interest in the search of preventive measures, such as dietary factors, is growing significantly. In this study we tested, in vitro and in vivo, the potential anti-cancer effect of the acetyl deacylasadisulfide (ADA), a vinyl disulfide compound, isolated and purified from asafoetida a foul-smelling oleo gum-resin of dietary and medicinal relevance. ADA markedly suppressed proliferation of human melanoma cell lines by inducing apoptosis...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28263848/phaleria-macrocarpa-boerl-fruit-induce-g0-g1-and-g2-m-cell-cycle-arrest-and-apoptosis-through-mitochondria-mediated-pathway-in-mda-mb-231-human-breast-cancer-cell
#6
Nowroji Kavitha, Chern Ein Oon, Yeng Chen, Jagat R Kanwar, Sreenivasan Sasidharan
ETHNOPHARMACOLOGICAL RELEVANCE: Phaleria macrocarpa (Scheff) Boerl, is a well-known folk medicinal plant in Indonesia. Traditionally, P. macrocarpa has been used to control cancer, impotency, hemorrhoids, diabetes mellitus, allergies, liver and hearth disease, kidney disorders, blood diseases, acne, stroke, migraine, and various skin diseases. AIM OF THE STUDY: The purpose of this study was to determine the in situ cytotoxicity effect P. macrocarpa fruit ethyl acetate fraction (PMEAF) and the underlying molecular mechanism of cell death...
March 2, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28254569/synthesis-and-characterization-of-core-shell-bimetallic-nanoparticles-for-synergistic-antimicrobial-effect-studies-in-combination-with-doxycycline-on-burn-specific-pathogens
#7
Ali Fakhri, Shiva Tahami, Mahsa Naji
Nano-medicine is a breakthrough discovery in the healthcare sector. Doxycycline is a new generation antibiotic which is proved to be a boon in the treatment of patients with complicated skin infections. We have tried to explore the benefits of synthesized bimetallic silver-gold nanoparticles in combination with new generation antibiotic for burn infections. The bimetallic nanoparticles synthesized by core-shell method were characterized using scanning electron microscopy equipped with an energy dispersive spectrometer, transmission electron microscopy, X-ray diffraction and UV-Vis spectroscopy...
February 27, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28252553/interactions-from-complementary-and-alternative-medicine-in-patients-with-melanoma
#8
Carmen Loquai, Irene Schmidtmann, Marlene Garzarolli, Martin Kaatz, Katharina C Kähler, Peter Kurschat, Frank Meiss, Oliver Micke, Ralph Muecke, Karsten Muenstedt, Dorothee Nashan, Annette Stein, Christoph Stoll, Dagmar Dechent, Jutta Huebner
Biological-based (BbCAM) methods from complementary and alternative medicine (CAM) may interact with cancer treatments, reduce efficacy, or enhance adverse effects. Although CAM usage has been evaluated well in other cancer entities, data on melanoma patients are still missing. The aim of this study was to determine CAM usage of melanoma patients using a standardized questionnaire to identify potential interactions with established and new systemic melanoma therapies. This multicenter study was carried out in seven German skin cancer centers...
March 1, 2017: Melanoma Research
https://www.readbyqxmd.com/read/28246541/a-review-of-black-salve-cancer-specificity-cure-and-cosmesis
#9
REVIEW
Andrew Croaker, Graham J King, John H Pyne, Shailendra Anoopkumar-Dukie, Lei Liu
Black salve is a topical escharotic used for the treatment of skin cancer. Although promoted as a safe and effective alternative to conventional management by its proponents, limited clinical research has been undertaken to assess its efficacy and potential toxicities. Patients are increasingly utilizing the Internet as a source of health information. As a minimally regulated space, the quality and accuracy of this information vary considerably. This review explores four health claims made by black salve vendors, investigating its natural therapy credentials, tumour specificity, and equivalence to orthodox medicine in relation to skin cancer cure rates and cosmesis...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28242546/characterization-and-evaluation-of-bioactive-polyphenolic-constituents-from-zanthoxylum-armatum-dc-a-traditionally-used-plant
#10
Zulfa Nooreen, Shilpi Singh, Dhananjay Kumar Singh, Sudeep Tandon, Ateeque Ahmad, Suaib Luqman
Zanthoxylum armatum or Timoor has been used in different traditional system of medicine due to its aromatic properties and also in the treatment of cancer, diarrhea and cholera. In the present investigation, four chemically distinct compounds namely Tambulin (6), Prudomestin (7), Ombuin (8) and 3, 4, 5, 3', 4', 5'-hexahydroxydiphenyl ether (9) have been isolated and quantified from the fruits. To explore the biological activities, we have further studied the antiproliferative, antimicrobial and antioxidant efficacy...
February 24, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28231262/oleanolic-acid-induces-migration-in-mv1lu-and-mda-mb-231-epithelial-cells-involving-egf-receptor-and-map-kinases-activation
#11
Ángel Bernabé-García, David Armero-Barranco, Sergio Liarte, María Ruzafa-Martínez, Antonio Jesús Ramos-Morcillo, Francisco José Nicolás
During wound healing, skin function is restored by the action of several cell types that undergo differentiation, migration, proliferation and/or apoptosis. These dynamics are tightly regulated by the evolution of the extra cellular matrix (ECM) contents along the process. Pharmacologically active flavonoids have shown to exhibit useful physiological properties interesting in pathological states. Among them, oleanolic acid (OA), a pentacyclic triterpene, shows promising properties over wound healing, as increased cell migration in vitro and improved wound resolution in vivo...
2017: PloS One
https://www.readbyqxmd.com/read/28216880/isolation-and-characterisation-of-a-proanthocyanidin-with-antioxidative-antibacterial-and-anti-cancer-properties-from-fern-blechnum-orientale
#12
How-Yee Lai, Yau-Yan Lim, Kah-Hwi Kim
BACKGROUND: Blechnum orientale Linn. (Blechnaceae), a fern, is traditionally used in the treatment of various ailments, such as skin diseases, stomach pain, urinary bladder complaints, and also as a female contraceptive. Previously, we reported a strong radical scavenging activity, antibacterial activity and cytotoxicity against HT29 colon cancer cells by aqueous extract of B. orientale. OBJECTIVE: In this study, we attempted to isolate and identify the active compound from the aqueous extract of B...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28193226/hair-growth-promoting-effect-of-geranium-sibiricum-extract-in-human-dermal-papilla-cells-and-c57bl-6-mice
#13
William A Boisvert, Miri Yu, Youngbin Choi, Gi Hee Jeong, Yi-Lin Zhang, Sunghun Cho, Changsun Choi, Sanghyun Lee, Bog-Hieu Lee
BACKGROUND: Geranium sibiricum L. has been used as a medicinal plant to treat diarrhea, bacterial infection, and cancer in Bulgaria, Peru, and Korea. However, its hair growth-promoting effect was not investigated so far. This study examined the effects of Geranium sibiricum L. extract (GSE) on hair growth, using in vitro and in vivo models. METHODS: Antioxidant, proliferation and migration assay of GSE was performed with human dermal papilla cells (hDPCs). Hair-growth promoting effect was measured in animal model...
February 13, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28191804/does-alternative-and-traditional-wasam-local-cautery-therapy-facilitate-an-early-and-more-extensive-locoregional-metastasis-of-breast-cancer
#14
(no author information available yet)
INTRODUCTION: A large heterogeneous group of unproven remedies exist to treat cancer in both developed and developing countries. Some of these remedies often do more harm than good to the patients. The traditional medicine is the sum total of the knowledge, skills, and practices based on the theories, beliefs, and experiences indigenous to different cultures. The traditional medicine in Oman is based on herbal treatment and skin treatment (massage, Cupping and skin burn "cautery" treatment-known as Wasam or Kaiy)...
September 2016: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28176669/effects-of-carotenoids-on-health-are-all-the-same-results-from-clinical-trials
#15
Arrigo F G Cicero, Alessandro Colletti
BACKGROUND: Oxidative stress is implicated in the pathogenesis of a lot of age-related pathologies and some types of cancers. Carotenoids have shown antioxidant properties, due to the ability to quench singlet oxygen and to scavenge free radicals that may prevent and treat a wide range of chronic diseases. The aim of this review is to discuss the clinical evidence present in literature about the effects of carotenoids on human health and to evaluate their effectiveness in the prevention and treatment of many chronic diseases...
February 6, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28141817/comparing-the-quality-of-ambulatory-surgical-care-for-skin-cancer-in-a-veterans-affairs-clinic-and-a-fee-for-service-practice-using-clinical-and-patient-reported-measures
#16
Matthew P Dizon, Eleni Linos, Sarah T Arron, Nancy K Hills, Mary-Margaret Chren
The Institute of Medicine has identified serious deficiencies in the measurement of cancer care quality, including the effects on quality of life and patient experience. Moreover, comparisons of quality in Veterans Affairs Medical Centers (VA) and other sites are timely now that many Veterans can choose where to seek care. To compare quality of ambulatory surgical care for keratinocyte carcinoma (KC) between a VA and fee-for-service (FFS) practice, we used unique clinical and patient-reported data from a comparative effectiveness study...
2017: PloS One
https://www.readbyqxmd.com/read/28133023/-breast-conserving-surgery-using-real-time-virtual-sonography-in-a-breast-cancer-patient-who-received-neoadjuvant-chemotherapy-acase-report
#17
Junta Sakakibara, Masahiro Sakakibara, Takafumi Sangai, Toshiaki Iwase, Takeshi Nagashima
We report a case of breast-conserving surgeryusing real-time virtual sonography(RVS)in a breast cancer patient who received neoadjuvant chemotherapy(NAC). The patient was a 63-year-old woman. Ultrasound(US)showed a lobulated 45 ×40×40mm diameter mass in the C area of the right breast. Histological examination found invasive ductal carcinoma that was negative for estrogen and progesterone receptors and for human epidermal growth factor receptor type 2/neu protein expression, and the Ki-67 index was 50%. The patient was diagnosed with breast cancer clinical stage II A(T2N0M0)...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28131913/the-paraguayan-rhinella-toad-venom-implications-in-the-traditional-medicine-and-proliferation-of-breast-cancer-cells
#18
Guillermo Schmeda-Hirschmann, Celeste Vega Gomez, Antonieta Rojas de Arias, Alberto Burgos-Edwards, Jorge Alfonso, Miriam Rolon, Francisco Brusquetti, Flavia Netto, Félix A Urra, César Cárdenas
ETHNOPHARMACOLOGICAL RELEVANCE: Toads belonging to genus Rhinella are used in Paraguayan traditional medicine to treat cancer and skin infections. AIM OF THE STUDY: The objective of the study was to determine the composition of venoms obtained from three different Paraguayan Rhinella species, to establish the constituents of a preparation sold in the capital city of Paraguay to treat cancer as containing the toad as ingredient, to establish the effect of the most active Rhinella schneideri venom on the cell cycle using human breast cancer cells and to assess the antiprotozoal activity of the venoms...
January 25, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28129687/a-case-of-anaphylaxis-to-patent-blue-in-a-patient-with-sentinel-lymph-node-excision
#19
Stefanie Aurich, Anna-Theresa Seitz, Janina Tomm, Jan-Christoph Simon, Regina Treudler
In medicine, patent blue violet (PBV) is utilized for staining lymphatic vessels in sentinel lymph node (SLN) surgery. Moreover, PBV (also called E131 ) is used as food additive. We report on a 51-year-old non-atopic female with early breast cancer, who was scheduled for SLN excision and experienced an intra-operative anaphylactic reaction. In diagnostics the skin prick test (SPT) was positive to PBV. Hypersensitivity reactions to PBV can arise after the first exposure in surgery as sensitization may arise from either PBV (E131) in foods (i...
December 2016: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28125738/antimelanogenic-antioxidant-and-antiproliferative-effects-of-antrodia-camphorata-fruiting-bodies-on-b16-f0-melanoma-cells
#20
Jyh-Jye Wang, Chih-Chung Wu, Chun-Lin Lee, Shu-Ling Hsieh, Jin-Bor Chen, Chu-I Lee
Antrodia camphorata is a fungus that is endemic to Taiwan, and its fruiting body has been used as a folk medicine for the prevention or treatment of diverse diseases. The present study is aimed at investigating the antimelanogenesis and antioxidation effect of the ethanolic extract of Antrodia camphorata fruiting body (EE-AC), as well as its antiproliferation effects in B16-F0 melanoma cells. Regarding antimelanogenic effects, EE-AC had effective cupric ions reducing capacity and expressed more potent inhibitory effect than kojic acid on mushroom tyrosinase activity...
2017: PloS One
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