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https://www.readbyqxmd.com/read/29914183/graviola-annona-muricata-exerts-anti-proliferative-anti-clonogenic-and-pro-apoptotic-effects-in-human-non-melanoma-skin-cancer-uw-bcc1-and-a431-cells-in-vitro-involvement-of-hedgehog-signaling
#1
Jean Christopher Chamcheu, Islam Rady, Roxane-Cherille N Chamcheu, Abu Bakar Siddique, Melissa B Bloch, Sergette Banang Mbeumi, Abiola S Babatunde, Mohammad B Uddin, Felicite K Noubissi, Peter W Jurutka, Yong-Yu Liu, Vladimir S Spiegelman, G Kerr Whitfield, Khalid A El Sayed
Non-melanoma skin cancers (NMSCs) are the leading cause of skin cancer-related morbidity and mortality. Effective strategies are needed to control NMSC occurrence and progression. Non-toxic, plant-derived extracts have been shown to exert multiple anti-cancer effects. Graviola ( Annona muricata ), a tropical fruit-bearing plant, has been used in traditional medicine against multiple human diseases including cancer. The current study investigated the effects of graviola leaf and stem extract (GLSE) and its solvent-extracted fractions on two human NMSC cell lines, UW-BCC1 and A431...
June 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29904398/apoptosis-and-antimigration-induction-in-human-skin-cancer-cells-by-rhodomyrtone
#2
Malatee Tayeh, Sirinun Nilwarangkoon, Chantra Tanunyutthawongse, Wilawan Mahabusarakum, Ramida Watanapokasin
Rhodomyrtone is a bioactive compound extracted from Rhodomyrtus tomentosa leaves. It has been used as a traditional herb medicine for many years. Rhodomyrtone exhibits antibacterial activity, anti-inflammatory and antioxidant activities. However, the anticancer activity of rhodomyrtone has not been previously reported. The present study investigated the anticancer effect of rhomyrtone on human epidermoid carcinoma A431 cells. The cytotoxic and antiproliferative effects of rhodomyrtone on A431 cells were investigated by an MTT assay...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29899947/electrochemical-imaging-of-cells-and-tissues
#3
REVIEW
Tzu-En Lin, Stefania Rapino, Hubert H Girault, Andreas Lesch
The technological and experimental progress in electrochemical imaging of biological specimens is discussed with a view on potential applications for skin cancer diagnostics, reproductive medicine and microbial testing. The electrochemical analysis of single cell activity inside cell cultures, 3D cellular aggregates and microtissues is based on the selective detection of electroactive species involved in biological functions. Electrochemical imaging strategies, based on nano/micrometric probes scanning over the sample and sensor array chips, respectively, can be made sensitive and selective without being affected by optical interference as many other microscopy techniques...
May 28, 2018: Chemical Science
https://www.readbyqxmd.com/read/29896978/associations-between-cancer-screening-behavior-and-complementary-medicine-use-results-of-a-national-cross-sectional-survey-of-9151-australian-women
#4
Jane Elizabeth Frawley, Erica McIntyre, David Sibbritt, Jon Wardle, Janet Schloss, Romy Lauche, Jon Adams
INTRODUCTION: Complementary medicine (CM) use has been found to influence the uptake of conventional cancer treatment. This study examines associations between CM use and cancer screening rates. METHODS: Women aged 62 to 67 years from the Australian Longitudinal Study on Women's Health were surveyed regarding their use of cancer screening initiatives. Associations between cancer screening behavior and visits to CM practitioners were analyzed. RESULTS: Of the 9151 women, 9049 (98...
June 1, 2018: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29894408/long-term-topical-corticosteroid-use-and-risk-of-skin-cancer-a-systematic-review
#5
Sonia Ratib, Esther Burden-Teh, Jo Leonardi-Bee, Catherine Harwood, Fiona Bath-Hextall
OBJECTIVE: The objective of this systematic review was to synthesize available research evidence to determine the risk of skin cancer in patients with long-term use of topical corticosteroids (TCS). INTRODUCTION: Topical corticosteroids are one of the most commonly prescribed medicines in dermatology and the mainstay of the treatment of atopic dermatitis and other skin conditions such as psoriasis. They are often required for months or years to control the disease and ultimately restore patients' quality of life...
June 2018: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29879588/the-protective-effect-of-some-thai-plants-and-their-bioactive-compounds-in-uv-light-induced-skin-carcinogenesis
#6
Madhura B de Silva, Tewin Tencomnao
Skin cancer, represents a major public health concern. While the vast majority is non-melanoma skin cancers, melanomas are mostly responsible for mortality. Solar UVB radiation is mutagenic and carcinogenic. It is primarily responsible for both non-melanoma and melanoma skin cancers via excessive production of reactive oxygen species (ROS), which mediate changes in inflammation and immunity, and have been implicated in all three stages of skin cancer development. Due to their regulatory role in numerous functions of cells, signaling pathways are targets for chemoprevention...
May 2, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29879257/naturopathic-self-treatment-of-an-atypical-fibroxanthoma-lessons-for-dermatologic-surgery
#7
Brandon Worley, Andrew J Nemechek, Samantha Stoler, Joel L Cohen
BACKGROUND: Alternative therapies are favored by some patients. In skin cancer, this may be to try to avoid surgery out of fear for the procedure and its functional or cosmetic consequences. Frequently, use of these therapies is not curative and can cause harm. Our objective is to detail a case where black salve was used as a natural remedy for an atypical fibroxanthoma and resulted in a severe burn. We highlight the challenges of communicating effective treatment options for those who have strong beliefs concerning natural remedies after a cancer diagnosis...
June 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29875660/-fructus-mume-extracts-alleviate-diarrhea-in-breast-cancer-patients-receiving-the-combination-therapy-of-lapatinib-and-capecitabine
#8
Hua Xing, Lirong Zhang, Jinshu Ma, Zhen Liu, Changlong Song, Yuxia Liu
Lapatinib and capecitabine have been widely used in the therapy of breast cancer. However, long-term use of lapatinib and capecitabine often causes the most common side effect diarrhea, which limit the medicine use. Fructus mume (F. mume) has been proved to be effective to treat chronic diarrhea with few side effects. The compounds from F. mume were extracted by using an ethanol method. Extracts of F. mume (EFM) were analyzed by HPLC. We investigated the protective effects of EFM on the diarrhea caused by lapatinib and capecitabine...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29867473/traditional-uses-pharmacological-efficacy-and-phytochemistry-of-moringa-peregrina-forssk-fiori-a-review
#9
REVIEW
Annadurai Senthilkumar, Noushad Karuvantevida, Luca Rastrelli, Shyam S Kurup, Abdul J Cheruth
Moringa is a sole genus of Moringaceae family with 13 species distributed in the tropical and sub-tropical regions. Among them, Moringa peregrina is one of the species which has wide range of traditional, nutritional, industrial, and medicinal values. The plant parts are used in folk medicine for many human health care purposes including diabetes, wound healing, disinfectant, fever, constipation, muscle pains, slimness, burns, labor pain, hypertension, malaria, stomach disorder, asthma, skin problems, and to expel a retained placenta...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29864953/plant-derived-anticancer-agents-a-green-approach-towards-skin-cancers
#10
REVIEW
Shakeel Ijaz, Naveed Akhtar, Muhammad Shoaib Khan, Abdul Hameed, Muhammad Irfan, Muhammad Adeel Arshad, Sajid Ali, Muhammad Asrar
Plants have been used as medicinal agents since the origin of mankind. High cost and severe side effects associated with conventional chemotherapy has limited their general acceptability and fuel up the search for alternate options. The alternative treatment options like phytochemicals have come up with ease of availability and cost effectiveness. Owing to their general acceptance, safety, low side effects and multistep targeting in signal transduction pathways, plant derived phyto-constituents have promising anti-carcinogenic potential for skin related cancers...
July 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29845800/attitude-of-a-sample-of-iranian-researchers-toward-the-future-of-stem-cell-research
#11
Mahdi Lotfipanah, Fereydoon Azadeh, Mehdi Totonchi, Reza Omani-Samani
Objective: Stem cells that have unlimited proliferation potential as well as differentiation potency are considered to be a promising future treatment method for incurable diseases. The aim of the present study is to evaluate the future trend of stem cell researches from researchers' viewpoints. Materials and Methods: This was a cross-sectional descriptive study on researchers involved in stem cell research at Royan Institute. We designed a questionnaire using a qualitative study based on expert opinion and a literature review...
October 2018: Cell Journal
https://www.readbyqxmd.com/read/29805736/bufalin-inhibits-gastric-cancer-invasion-and-metastasis-by-down-regulating-wnt-ascl2-expression
#12
Jie Wang, Han Cai, Yue Xia, Shiying Wang, Likai Xing, Chao Chen, Yong Zhang, Jie Xu, Peihao Yin, Yiming Jiang, Ronghua Zhao, Qingshong Zuo, Teng Chen
Achaete-scute-like 2 (ASCL2) is a transcription factor containing a basic helix-loop-helix (bHLH) domain and is a downstream target of Wnt signaling in intestinal stem cells. Bufalin is the primary active ingredient in Chan Su, a traditional Chinese medicine obtained from the skin and parotid venom glands of toads. The purpose of this study was to research the anti-invasion and anti-metastasis activity of bufalin in gastric cancer and to identify the potential mechanism. Bufalin inhibited gastric cancer cell invasion and metastasis, suppressed cancer cell colony formation, and inhibited the growth of subcutaneous xenografted tumors in nude mice...
May 4, 2018: Oncotarget
https://www.readbyqxmd.com/read/29801061/interest-and-uptake-of-mc1r-testing-for-melanoma-risk-in-a-diverse-primary-care-population-a-randomized-clinical-trial
#13
Jennifer L Hay, Kate Zielaskowski, Kirsten Meyer White, Kimberly Kaphingst, Erika Robers, Dolores Guest, Andrew Sussman, Yvonne Talamantes, Matthew Schwartz, Vivian M Rodríguez, Yuelin Li, Elizabeth Schofield, Jessica Bigney, Keith Hunley, David Buller, Marianne Berwick
Importance: Germline variants in the MC1R gene are common and confer moderate melanoma risk in those with varied skin types. Approaches to precision skin cancer prevention that include genetic information may promote risk awareness and risk reduction in the general population, including Hispanics. Objective: To examine prevalence of interest in and uptake of MC1R testing in the general population and examine patterns across demographic and skin cancer risk factors...
May 9, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/29794405/cinobufacini-inhibits-epithelial-mesenchymal-transition-of-human-hepatocellular-carcinoma-cells-through-c-met-erk-signaling-pathway
#14
Fanghua Qi, Jinjing Wang, Lin Zhao, Pingping Cai, Wei Tang, Zhixue Wang
Cinobufacini, an aqueous extract from the skins and parotid venom glands of the toad Bufo bufo gargarizans Cantor, is a well known traditional Chinese medicine widely used in clinical cancer therapy in China. Its therapeutic effect is especially pronounced in liver cancer. However, the precise mechanisms induced by cinobufacini in human hepatocellular carcinoma (HCC) cells are still not very clear. Here, we investigated the effects and mechanisms of cinobufacini on inhibiting HepG2 cells invasion and metastasis...
May 22, 2018: Bioscience Trends
https://www.readbyqxmd.com/read/29783238/clinical-efficiency-of-dynamic-observation-of-patients-with-epidermal-dysplasia-of-the-skin
#15
Oleg L Ziukov, Оlena O Oshyvalova
OBJECTIVE: Introduction: Non-melanoma skin cancer is the most common type of cancer among the population of Ukraine. The aim: The study of clinical efficacy of dynamic observation of patients with epidermal dysplasia of the skin. PATIENTS AND METHODS: Materials and methods: To study epidermal dysplasia of the skin there was used identifying information of patients, who were under dynamic observation of dermatologists of the State Scientific Institution "Research and Practical Centre of Preventive and Clinical Medicine" of the State Administration in 2013-2017...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29782309/in-memoriam-assistant-professor-kre%C3%A5-imir-kostovi%C3%A4-md-phd-16-october-1969-15-october-2017
#16
Branka Marinović
On a Sunday afternoon almost six months ago, we were deeply moved by the news that our Krešimir is no longer with us. The sad news spread from Sarajevo with the speed only most horrible and saddest news can achieve. And everybody who was reached by these news wondered whether it was possible and whether it was true. Because our professor Kostović left us a day before his 48th birthday. Krešimir Kostović was born on the 16th October 1969 in Zagreb, where he completed primary and secondary education. He enrolled at the University of Zagreb School of Medicine in 1988, and got his medical degree in 1995...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29770129/cutaneous-papillomaviruses-and-non-melanoma-skin-cancer-causal-agents-or-innocent-bystanders
#17
REVIEW
Daniel Hasche, Sabrina E Vinzón, Frank Rösl
There is still controversy in the scientific field about whether certain types of cutaneous human papillomaviruses (HPVs) are causally involved in the development of non-melanoma skin cancer (NMSC). Deciphering the etiological role of cutaneous HPVs requires - besides tissue culture systems - appropriate preclinical models to match the obtained results with clinical data from affected patients. Clear scientific evidence about the etiology and underlying mechanisms involved in NMSC development is fundamental to provide reasonable arguments for public health institutions to classify at least certain cutaneous HPVs as group 1 carcinogens...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29766198/aquaporins-in-cancer-development-opportunities-for-bioinorganic-chemistry-to-contribute-novel-chemical-probes-and-therapeutic-agents
#18
REVIEW
Brech Aikman, Andreia de Almeida, Samuel M Meier-Menches, Angela Casini
Aquaporins (AQPs) are membrane proteins allowing permeation of water, glycerol & hydrogen peroxide across biomembranes, and playing an important role in water homeostasis in different organs, exocrine gland secretion, urine concentration, skin moisturization, fat metabolism and neural signal transduction. Notably, a large number of studies showed that AQPs are closely associated with cancer biological functions and expressed in more than 20 human cancer cell types. Furthermore, AQP expression is positively correlated with tumour types, grades, proliferation, migration, angiogenesis, as well as tumour-associated oedema, rendering these membrane channels attractive as both diagnostic and therapeutic targets in cancer...
May 16, 2018: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29764209/next-gen-therapeutics-for-skin-cancer-nutraceuticals
#19
Annapoorna Sreedhar, Jun Li, Yunfeng Zhao
Growing modernization and lifestyle changes with limited physical activity have impacted diet and health, leading to an increased cancer mortality rate worldwide. As a result, there is a greater need than before to develop safe and novel anticancer drugs. Current treatment options such as chemotherapy, radiotherapy and surgery, induce unintended side effects, compromising patient's quality of life, and physical well-being. Therefore, there has been an increased global interest in the use of dietary supplements and traditional herbal medicines for treatment of cancer...
May 15, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29762071/vla-4-mediated-adhesion-of-melanoma-cells-on-the-blood-brain-barrier-is-the-critical-cue-for-melanoma-cell-intercalation-and-barrier-disruption
#20
Ana B García-Martín, Pascale Zwicky, Thomas Gruber, Christoph Matti, Federica Moalli, Jens V Stein, David Francisco, Gaby Enzmann, Mitchell P Levesque, Ekkehard Hewer, Ruth Lyck
Melanoma is the most aggressive skin cancer in humans. One severe complication is the formation of brain metastasis, which requires extravasation of melanoma cells across the tight blood-brain barrier (BBB). Previously, VLA-4 has been assigned a role for the adhesive interaction of melanoma cells with non-BBB endothelial cells. However, the role of melanoma VLA-4 for breaching the BBB remained unknown. In this study, we used a mouse in vitro BBB model and imaged the shear resistant arrest of melanoma cells on the BBB...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
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