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skin cancer medicine and surgery

James W Behan, Adam Sutton, Ashley Wysong
Skin cancer is the most common of human cancers and outnumbers all other types of cancer combined in the USA by over threefold. The majority of non-melanoma skin cancers are easily treated with surgery or locally destructive techniques performed under local anesthesia in the cost-effective outpatient setting. However, there is a subset of "high-risk" cases that prove challenging in terms of morbidity, mortality, adjuvant treatment required, as well as overall cost to the health care system. In our opinion, the term "high risk" when applied to skin cancer can mean one of three things: a high-risk tumor with aggressive histologic and/or clinical features with an elevated risk for local recurrence or regional/distant metastasis, a high-risk patient with the ongoing development of multiple skin cancers, and a high-risk patient based on immunosuppression...
December 2016: Current Treatment Options in Oncology
S M Nieves Maldonado, V Pubul Núñez, S Argibay Vázquez, M Macías Cortiñas, Á Ruibal Morell
A 49 year-old woman diagnosed with infiltrating lobular breast carcinoma, underwent a right mastectomy and sentinel node biopsy (SLNB). The resected sentinel lymph nodes were negative for malignancy, with an axillary lymphadenectomy not being performed. In the early post-operative period, the patient reported an axillary skin tension sensation, associated with a painful palpable cord. These are typical manifestations of axillary web syndrome (AWS), a poorly known axillary surgery complication, from both invasive and conservative interventions...
September 2016: Revista Española de Medicina Nuclear e Imagen Molecular
Ou Huang, Dandan Wu, Li Zhu, Yafen Li, Weiguo Chen, Kunwei Shen
BACKGROUND: To compare the efficacy of concurrent and sequential administration of radiotherapy and chemotherapy on patients with operable breast cancer after breast.conserving surgery. (BCS). MATERIALS AND METHODS: We searched MEDLINE (National Library of Medicine, Bethesda, Maryland) and EMBASE (Elsevier, Amsterdam, Netherlands) databases for eligible studies. Clinical outcomes (such as overall and locoregional recurrence-free survival, toxicity related complications) used as evaluation indexes of efficacy...
January 2016: Journal of Cancer Research and Therapeutics
Reinhard Dummer, Dirk Schadendorf, Paolo A Ascierto, James Larkin, Celeste Lebbé, Axel Hauschild
Melanoma remains a serious form of skin cancer in Europe and worldwide. Localized, early-stage melanomas can usually be treated with surgical excision. However, the prognosis is poorer for patients with advanced disease. Before 2011, treatment for advanced melanoma included palliative surgery and/or radiotherapy, and chemotherapy with or without immunotherapy, such as interleukin-2. As none of these treatments had shown survival benefits in patients with advanced melanoma, European guidelines had recommended that patients be entered into clinical trials...
December 2015: Melanoma Research
Tanja Planinšek Ručigaj, Kristina Janežič, Jasna Lipozenčić
No abstract text is available yet for this article.
2015: Acta Dermatovenerologica Croatica: ADC
Pei-Rong Tian, Wei-Tao Zhang, Zhi Xu
Malignant tumors pose a serious threat to mankind health and life. As a result, early diagnosis is very important. In recent years, Fourier transform infrared spectroscopy has shown enormous development potential of cancer diagnosis. Compared with traditional methods, this technology has apparent advantages in the aspects of accuracy, rapidity, noninvasion, in situ, cheapness, automation, replication, without pretreatment and early diagnosis at the molecular level. This paper summarized study progress that FTIR technology applied in diagnosis of respiratory system tumor, digestive system tumor, urinary genital system tumor, brain tumor, skin tumor and blood system tumor, and combined with the international present state of clinical medicine, spectroscopy and chemometrics, five prospects were put forward: expand the sample size and undertake multi-center study; combined with endoscopy and puncture biopsy to guide real-time in situ diagnosis and biopsy during surgery; further automated; find more efficient chemometric methods; the identification of individual parameters has yet to be confirmed by further studies...
October 2014: Guang Pu Xue Yu Guang Pu Fen Xi, Guang Pu
Bo-ying Li, Chun-sheng Jia, Jian-ling Wang, Zhan-na Tan, Xue-liang Zhu, Jing Shi, Yan-hui Sun, Xiao-feng Li, Xuan-ping Zhang, Xin Zhang, Jing Xu
OBJECTIVE: To discuss the specificity of diseases treated by moxibustion and fire needling in clinical practice, so as to provide references for clinical treatment. METHODS: With data mining of modern computer technique, journal and literature databases regarding moxibustion and fire needling were established, respectively. Literature regarding moxibustion and fire needling for the past 60 years has been collected, screened, included, reviewed and abstracted. The utility rate of moxibustion and fire needling in each department was calculated, frequency of diseases in clinical practice was summarized, and diseases which had differences in clinical practice in each department were screened; also the advantages of disease categories and clinical practice between two kinds of therapies in each department were compared...
November 2014: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
Hyung Kwon Byeon, F Christopher Holsinger, Ralph P Tufano, Hyo Jin Chung, Won Shik Kim, Yoon Woo Koh, Eun Chang Choi
BACKGROUND: Traditionally, total thyroidectomy was performed through an open transcervical incision; in cases where there was evident nodal metastasis, the conventional surgical approach was to extend the incision into a large single transverse incision to complete the required neck dissection. However, recent innovation in the surgical technique of thyroidectomy has offered the opportunity to reduce the patient's burden from these prominent surgical scars in the neck. Minimally invasive surgical techniques have been developed and applied by many institutions worldwide, and more recently, various techniques of remote access surgery have been suggested and actively applied...
November 2014: Annals of Surgical Oncology
D Mitton, R Ackroyd
Although the concept photodynamic therapy has been recognised for over a century, it is only over the last 25 years that it has been used in Great Britain. The first applications in the UK were in 1981 by John Carruth, who treated patients with advanced ENT and skin cancers. The following year, he and Stephen Bown set up the British Medical Laser Association (BMLA). Since that time, the use of PDT in the UK has slowly expanded in all fields of medicine and surgery. In 1986, Bown set up the National Medical Laser Centre (NMLC) and later collaborated with Liverpool gastroenterologist, Neville Krasner, in animal studies on rat colon...
December 2005: Photodiagnosis and Photodynamic Therapy
Megan J Schlichte, Christopher P Downing, Marigdalia Ramirez-Fort, Rachel Gordon, Stephen Tyring
We present a case of a 60-year-old woman who, after using a blemish cream purchased at a health store, presented to our clinic with a large eschar on the right neck. The active ingredient in this cream was found to be Sanguinaria canadensis, a known escharotic. This substance is popularly marketed as a natural remedy for a host of skin diseases such as blemishes, moles, warts, skin tags, basal cell carcinomas, squamous cell carcinomas, actinic keratoses, and even melanoma. The patient was treated with topical corticosteroids but is still left with a scar from the healed eschar...
July 2014: Dermatology Online Journal
Antoine F Carpentier
In case of cancer dissemination to the brain, surgery and radiosurgery of all the brain metastases must be considered when possible. In other cases, whole brain radiotherapy remains the standard of care. The place of chemotherapy in this strategy remains debated. New targeted therapy, which might be even more efficient than cytotoxic chemotherapy, will probably challenge upfront radiotherapy in the next years to come.
May 2014: La Revue du Praticien
Eun Jeong Ban, Ji Young Yoo, Won Woong Kim, Hae Young Son, Seulkee Park, So Hee Lee, Cho Rok Lee, Sang-Wook Kang, Jong Ju Jeong, Kee-Hyun Nam, Woong Youn Chung, Cheong Soo Park
BACKGROUND: Robotic thyroidectomy (RT), a new gasless, transaxillary approach developed by the Yonsei University group in Seoul, Korea, eliminates the need for a cervical incision. Since RT is technically complex and has a steep learning curve, the surgical complication rate may initially be higher than with conventional surgery. This study evaluated the complication rates of transaxillary RT and assessed ways to prevent surgical complications. METHODS: Between October 2007 and March 2013, 3,000 patients underwent RT for thyroid cancer in the Department of Surgery, Yonsei University College of Medicine at Severance Hospital, Seoul...
September 2014: Surgical Endoscopy
R H Ozcan, A Topkara, D Bagdatli, A Ozkan, O Aydın, T Celebi
OBJECTIVES: Breast cancer is the most common non-skin malignancy in women. In breast cancer, the basic principle of endocrine therapy is to deprive tumor cell from the growth-stimulating effect of estrogens. The oldest, best-known and most widely used endocrine therapy medicine is tamoxifen, which is a selective estrogen receptor blocker. All factors that are known to have adverse effects on flap and pre-reconstruction flap survive should be eliminated 3 weeks before the surgery and started at the end of the 3rd week after the surgery...
2014: European Review for Medical and Pharmacological Sciences
Morteza Jalali, William Niall Alexander Kirkpatrick, Malcolm Gregor Cameron, Siim Pauklin, Ludovic Vallier
Human stem cell research represents an exceptional opportunity for regenerative medicine and the surgical reconstruction of the craniomaxillofacial complex. The correct architecture and function of the vastly diverse tissues of this important anatomical region are critical for life supportive processes, the delivery of senses, social interaction, and aesthetics. Craniomaxillofacial tissue loss is commonly associated with inflammatory responses of the surrounding tissue, significant scarring, disfigurement, and psychological sequelae as an inevitable consequence...
July 1, 2014: Stem Cells and Development
Yao Fu, Shuwen Deng, Jing Wang, Zhaozhao Chen, Shu Zhang, Songtao Wu, Yan Jiang, Ling Ye, Qiang Peng, Yunfeng Lin
The craniofacial region contains many specified tissues, including bone, cartilage, muscle, blood vessels, fat, skin and neurons. A defect or dysfunction of the craniofacial tissue after post-cancer ablative surgery, trauma, congenital malformations and progressive deforming skeletal diseases has a huge influence on the patient's life. Therefore, functional reconstruction of damaged tissues is highly sought. The use of cell-based therapies represents one of the most advanced methods for enhancing the regenerative response for craniofacial wound-healing...
May 2014: Current Stem Cell Research & Therapy
Anca Bordianu, I P Florescu, Anca Mureşan, Elena Bernad, M Craina, Izabella Şargan
More than one third of all diagnosed cancer cases from all over the world are skin cancers, and the majorities are basal cell carcinomas. The incidence of skin tumors around the world is growing, the main concern being the increased frequency of skin tumors among young persons. Therefore, an early detection is required, starting with the general practitioner, dermatologist, oncologist, plastic surgeon and not least, the pathologist. We studied a sample consisting of 149 patients diagnosed with basal cell carcinoma at the level of the cephalic end and neck, all of them undergoing surgery--surgery individualized for each case...
2013: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
Alexandre Pompeo, Marcos Tobias-Machado, Wilson R Molina, Jarkes Lucio, David Sehrt, Antonio Carlos Lima Pompeo, Fernando J Kim
PURPOSE: To report the surgical technique, procedural outcomes, and feasibility of simultaneous bilateral Video Endoscopic Inguinal Lymphadenectomy (VEIL) in the management of patients with indication for inguinal lymphadenectomy. SURGICAL TECHNIQUE: VEIL was applied in all patients using the oncological landmarks (the adductor longus muscle medially, the sartorius muscle laterally and the inguinal ligament superiorly). A 1.5 cm incision was made 2 cm distally to the lower vertex of the femoral triangle...
July 2013: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Lindsay Corsini
Radiation therapy used alone or in combination with chemotherapy and/or surgery for the treatment of cancer can be extremely problematic and painful to the patient. The adverse effects of radiation therapy include dryness, itching, peeling, or blistering of the skin. There are numerous formulas and compounds that can be utilized to help patients with radiation burns. The compounding pharmacist, physician, and patient can work together to help increase the quality of life for a patient that is undergoing a treatment that can be very mentally and physically painful...
May 2010: International Journal of Pharmaceutical Compounding
Admire Matsika, Bhuvana Srinivasan, Janet Meryl Gray, Christine Ruth Galbraith
A tattoo is defined as the intentional or accidental deposit of pigment into the skin. The phenomenon of skin tattooing is on the rise worldwide and complications of tattooing are increasingly being recognised in diagnostic and clinical medicine. We describe a case of calcification-like changes on mammography resembling that of breast malignancy as a result of tattoo pigment deposition in an axillary lymph node. Recognition of such changes in routine breast screening is crucial to avoid further unnecessary invasive investigations and surgery in such patients...
2013: BMJ Case Reports
Francesco Farace, Antonio Bulla, Francesco Marongiu, Gian Vittorio Campus, Francesco Tanda, Amelia Lissia, Antonio Cossu, Claudio Fozza, Corrado Rubino
UNLABELLED: Anaplastic large cell lymphoma (ALCL) of the breast is a very rare nonepithelial neoplasm. In the literature, this tumor has sometimes been described in proximity of breast implants (60 implant-related ALCL reported). In 2010, a patient who had undergone a right mastectomy and tissue expander/implant reconstruction for a "ductal" carcinoma 10 years before was referred to our unit for evaluation. On examination, an enlarged reconstructed right breast was found. The reconstructed breast did not show tenderness or signs of infection, ulceration, or breakdown...
June 2013: Aesthetic Plastic Surgery
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