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https://www.readbyqxmd.com/read/28089161/genome-wide-gene-expression-patterns-in-dikaryon-of-the-basidiomycete-fungus-pleurotus-ostreatus
#1
Tianxiang Liu, Huiru Li, Yatong Ding, Yuancheng Qi, Yuqian Gao, Andong Song, Jinwen Shen, Liyou Qiu
Dikarya is a subkingdom of fungi that includes Ascomycota and Basidiomycota. The gene expression patterns of dikaryon are poorly understood. In this study, we bred a dikaryon DK13×3 by mating monokaryons MK13 and MK3, which were from the basidiospores of Pleurotus ostreatus TD300. Using RNA-Seq, we obtained the transcriptomes of the three strains. We found that the total transcript numbers in the transcriptomes of the three strains were all more than ten thousand, and the expression profile in DK13×3 was more similar to MK13 than MK3...
January 3, 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/28068396/effects-of-pulp-and-na-bentonite-amendments-on-the-mobility-of-trace-elements-soil-enzymes-activity-and-microbial-parameters-under-ex-situ-aided-phytostabilization
#2
Daniel Wasilkowski, Anna Nowak, Grażyna Płaza, Agnieszka Mrozik
The objective of this study was to explore the potential use of pulp (by-product) from coffee processing and Na-bentonite (commercial product) for minimizing the environmental risk of Zn, Pb and Cd in soil collected from a former mine and zinc-lead smelter. The effects of soil amendments on the physicochemical properties of soil, the structural and functional diversity of the soil microbiome as well as soil enzymes were investigated. Moreover, biomass of Festuca arundinacea Schreb. (cultivar Asterix) and the uptake of trace elements in plant tissues were studied...
2017: PloS One
https://www.readbyqxmd.com/read/28058025/relationship-between-ghrelin-helicobacter-pylori-and-gastric-mucosal-atrophy-in-hemodialysis-patients
#3
Hitomi Ichikawa, Mitsushige Sugimoto, Yukitoshi Sakao, Shu Sahara, Naro Ohashi, Akihiko Kato, Ken Sugimoto, Takahisa Furuta, Akira Andoh, Tadashi Sakao, Hideo Yasuda
AIM: To investigate the relationship between plasma ghrelin level, Helicobacter pylori (H. pylori) infection status and the severity of atrophy in hemodialysis patients. METHODS: One hundred eights patients who received hemodialysis and 13 non-hemodialysis H. pylori-negative controls underwent gastroduodenoscopy to evaluate the severity of gastric atrophy. Serum levels of pepsinogen (PG) were measured as serum markers of gastric atrophy. H. pylori infection was evaluated by anti-H...
December 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28054994/synthesis-of-new-nitrofluoroquinolone-derivatives-with-novel-anti-microbial-properties-against-metronidazole-resistant-h-pylori
#4
Luay Abu-Qatouseh, Mohammad Abu-Sini, Amal Mayyas, Yusuf Al-Hiari, Rula Darwish, Talal Aburjai
One of the major therapeutic approaches to preventing relapse and accelerating the healing of duodenal and gastric ulcers is the eradication of Helicobacter pylori. Due to the emergence of antibiotic resistance among clinical strains of H. pylori, alternative approaches using newly discovered antimicrobial agents in combination with the standard regimens for the treatment of H. pylori are increasingly needed. The purpose of the present study was to investigate the effect of newly synthesized 8-nitroflouroqunolone derivatives when used either alone or when combined with metronidazole against metronidazole-resistant H...
January 4, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28054971/the-development-of-urease-inhibitors-what-opportunities-exist-for-better-treatment-of-helicobacter-pylori-infection-in-children
#5
Sherif T S Hassan, Miroslava Šudomová
Stomach infection with Helicobacter pylori (H. pylori) causes severe gastroduodenal diseases in a large number of patients worldwide. The H. pylori infection breaks up in early childhood, persists lifelong if not treated, and is associated with chronic gastritis and an increased risk of peptic ulcers and gastric cancer. In recent years, the problem of drug-resistant strains has become a global concern that makes the treatment more complicated and the infection persistent at higher levels when the antibiotic treatment is stopped...
January 4, 2017: Children
https://www.readbyqxmd.com/read/28053590/in-vitro-biocontrol-activity-of-halotolerant-streptomyces-aureofaciens-k20-a-potent-antagonist-against-macrophomina-phaseolina-tassi-goid
#6
P Shrivastava, R Kumar, M S Yandigeri
A halotolerant actinobacterial strain isolated from salinity affected soil of Eastern Indo-Gangetic plains (IGP), Uttar Pradesh, India, was characterised for its antagonistic potential against Macrophomina phaseolina by dual-culture assay. It was shown to effectively inhibit the growth of M. phaseolina with an inhibition zone of 27 ± 1.33 mm. Further the actinobacterial strain was evaluated for its plant growth promoting (PGP) properties and its ability to produce biocontrol related extracellular enzymes viz...
January 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28049442/analyzing-the-influence-of-gastric-intestinal-metaplasia-on-gastric-ulcer-healing-in-helicobacter-pylori-infected-patients-without-atrophic-gastritis
#7
Li-Wei Chen, Liang-Che Chang, Chung-Ching Hua, Bor-Jen Hsieh, Shuo-Wei Chen, Rong-Nan Chien
BACKGROUND: Gastric epithelial hyper-proliferation was reported in patients with Helicobacter pylori (H. pylori)-infected gastric mucosa with intestinal metaplasia (IM) changes. In patients with gastric ulcer (GU) and IM, the GU may have a different healing rate in comparison to patients without IM. This study aimed to compare the difference in GU healing between H. pylori-infected patients with IM and those without IM. METHODS: We retrospectively analyzed patients at the Keelung Chung Gung Memorial Hospital during the period from March 2005 to January 2011...
January 3, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28045966/inhibition-of-helicobacter-pylori-and-its-associated-urease-by-palmatine-investigation-on-the-potential-mechanism
#8
Jiang-Tao Zhou, Cai-Lan Li, Li-Hua Tan, Yi-Fei Xu, Yu-Hong Liu, Zhi-Zhun Mo, Yao-Xing Dou, Rui Su, Zi-Ren Su, Ping Huang, Jian-Hui Xie
In this paper, we evaluated the anti-Helicobacter pylori activity and the possible inhibitory effect on its associated urease by Palmatine (Pal) from Coptis chinensis, and explored the potential underlying mechanism. Results indicated that Pal exerted inhibitory effect on four tested H. pylori strains (ATCC 43504, NCTC 26695, SS1 and ICDC 111001) by the agar dilution test with minimum inhibitory concentration (MIC) values ranging from 100 to 200 μg/mL under neutral environment (pH 7.4), and from 75 to 100 μg/mL under acidic conditions (pH 5...
2017: PloS One
https://www.readbyqxmd.com/read/28042765/study-of-serum-levels-of-some-oxidative-stress-markers-in-children-with-helicobacter-pylori-infection
#9
Adel A Hagag, Saleh M Amin, Rasha B El-Fiky, Magda E El-Sayad
BACKGROUND: Helicobacter pylori are gram-negative spiral shaped bacteria, with sheathed flagella. H. pylori infection is one of the most common chronic infections in humans. Infection is usually acquired during childhood, and becomes a lifelong infection in most people unless treated. The aim of this study was to evaluate serum levels of oxidative stress indices in children with H. pylori infection. MATERIAL AND METHODS: The present study was carried out on 60 children infected with H...
January 2, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28033692/helicobacter-pylori-and-its-virulence-factors-effect-on-serum-oxidative-dna-damages-in-adults-with-dyspepsia
#10
Heshmat Shahi, Rasoul Bahreiny, Somayeh Reiisi
Helicobacter Pylori infection is a common gastrointestinal infection that can cause pathological effects, increase oxidative stress and induce an inflammatory response in gastric mucosa. Inflammatory aspects may prompt the production of radical oxygen substance (ROS) which may damage cells and release 8-hydroxydyoxyguanosine (8-OHdG) to serum. In this study, we evaluate the prevalence of H. pylori virulence factors and the association between serum level of 8-OHdG, H. pylori infection, and its various virulence factors...
November 2016: Acta Medica Iranica
https://www.readbyqxmd.com/read/28024098/helicobacter-pylori-serology-testing-is-a-useful-diagnostic-screening-tool-for-symptomatic-inner-city-children
#11
Priya Raj, John F Thompson, Debra H Pan
AIM: This study assessed the Helicobacter pylori (H. pylori) serum antibody test as a diagnostic screening tool in symptomatic inner city children. METHODS: This was a retrospective study of patients aged 1-18 years who were referred to our paediatric gastroenterology department from 2009-2013. We included all patients who had H. pylori serum antibodies and, or, faecal antigens who underwent esophagogastroduodenoscopy (EGD) for histology, with or without a gastric tissue rapid urease test...
December 26, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/28018307/variable-effects-of-non-steroidal-anti-inflammatory-drugs-nsaids-on-selected-biochemical-processes-mediated-by-soil-microorganisms
#12
Mariusz Cycoń, Sławomir Borymski, Bartłomiej Żołnierczyk, Zofia Piotrowska-Seget
Non-steroidal anti-inflammatory drugs (NSAIDs) are the most frequently used group of pharmaceuticals. The high consumption and the uncontrolled disposal of unused drugs into municipal waste or their deposit in landfills can result in an increased concentration of these compounds in soils. Moreover, these drugs can affect the microbial activity. However, there is a lack of knowledge about these effects or it is very limited. Therefore, the objective of this study was to compare the impact of selected commercially available NSAIDs, i...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28018009/bioaugmentation-of-soil-contaminated-with-azoxystrobin
#13
Małgorzata Baćmaga, Jadwiga Wyszkowska, Jan Kucharski
The presence of fungicides in the natural environment, either resulting from deliberate actions or not, has become a serious threat to many ecosystems, including soil. This can be prevented by taking appropriate measures to clear the environment of organic contamination, including fungicides. Therefore, a study was conducted aimed at determining the effect of bioaugmentation of soil exposed to azoxystrobin on its degradation and activity of selected enzymes (dehydrogenases, catalase, urease, acidic phosphatase, alkaline phosphatase)...
2017: Water, Air, and Soil Pollution
https://www.readbyqxmd.com/read/28017513/from-catheter-to-kidney-stone-the-uropathogenic-lifestyle-of-proteus-mirabilis
#14
REVIEW
Allison N Norsworthy, Melanie M Pearson
Proteus mirabilis is a model organism for urease-producing uropathogens. These diverse bacteria cause infection stones in the urinary tract and form crystalline biofilms on indwelling urinary catheters, frequently leading to polymicrobial infection. Recent work has elucidated how P. mirabilis causes all of these disease states. Particularly exciting is the discovery that this bacterium forms large clusters in the bladder lumen that are sites for stone formation. These clusters, and other steps of infection, require two virulence factors in particular: urease and MR/P fimbriae...
December 22, 2016: Trends in Microbiology
https://www.readbyqxmd.com/read/28013473/pollution-in-the-urban-soils-of-lianyungang-china-evaluated-using-a-pollution-index-mobility-of-heavy-metals-and-enzymatic-activities
#15
Yu Li, Hong-Guan Li, Fu-Cheng Liu
Soil samples from 16 urban sites in Lianyungang, China were collected and analyzed. A pollution index was used to assess the potential ecological risk of heavy metals and a sequential extraction procedure was used to evaluate the relative distribution of Cu, Zn, Pb, Cd, Cr, and As in exchangeable, carbonate, Fe/Mn oxide, organic/sulfide, and residual fractions. The mobility of heavy metals and urease (URE) activity, alkaline phosphatase (ALP) activity, and invertase (INV) activity of soils was determined. The results showed that the average concentrations of Cu, Zn, Pb, Cd, Cr, and As in Lianyungang soils were much higher than those in the coastal city soil background values of Jiangsu and China...
January 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28011429/phytostabilization-of-zn-pb-ore-flotation-tailings-with-dianthus-carthusianorum-and-biscutella-laevigata-after-amending-with-mineral-fertilizers-or-sewage-sludge
#16
Krystyna Ciarkowska, Ewa Hanus-Fajerska, Florian Gambuś, Ewa Muszyńska, Tomasz Czech
Zinc-lead mining wastes remain largely unvegetated and prone to erosion for many years because of phytotoxic levels of residual heavy metals, low nutrient status and poor physical structure. The optimal solution for these areas is to restore plant cover using species which spontaneously appear on the spoils. These species are adapted to the conditions of tailings, and their establishment will promote further vegetation by increasing soil organic matter and development of a soil system capable of supporting the nutrient and water requirements of plants and microoorganisms...
December 20, 2016: Journal of Environmental Management
https://www.readbyqxmd.com/read/28011200/synthesis-x-ray-molecular-structure-biological-evaluation-and-molecular-docking-studies-of-some-n-4-benzyl-substituted-5-nitroisatin-3-thiosemicarbazones
#17
Humayun Pervez, Nazia Khan, Sumera Zaib, Muhammad Yaqub, Muhammad Moazzam Naseer, Muhammad Nawaz Tahir, Jamshed Iqbal
A series of fifteen N(4)-benzyl substituted 5-nitroisatin-3-thiosemicarbazones 5a-o was synthesized and evaluated for urease inhibitory, phytotoxic and cytotoxic influences. All the compounds proved to be highly potent inhibitors of the enzyme, showing inhibitory activity (IC50=0.87±0.25-8.09±0.23μM) much better than the reference inhibitor, thiourea (IC50=22.3±1.12μM) and may thus act as persuasive leads for further studies. In phytotoxicity assay, twelve out of fifteen thiosemicarbazones tested i.e. 5a-e, 5g, 5i and 5k-o appeared to be active, exhibiting weak or non-significant (5-35%) growth inhibition at the highest tested concentrations (1000 or 500μg/mL)...
December 10, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28004186/non-thiolate-ligation-of-nickel-by-nucleotide-free-ureg-of-klebsiella-aerogenes
#18
Vlad Martin-Diaconescu, Crisjoe A Joseph, Jodi L Boer, Scott B Mulrooney, Robert P Hausinger, Michael J Maroney
Nickel-dependent ureases are activated by a multiprotein complex that includes the GTPase UreG. Prior studies showed that nucleotide-free UreG from Klebsiella aerogenes is monomeric and binds one nickel or zinc ion with near-equivalent affinity using an undefined binding site, whereas nucleotide-free UreG from Helicobacter pylori selectively binds one zinc ion per dimer via a universally conserved Cys-Pro-His motif in each protomer. Iodoacetamide-treated K. aerogenes UreG was nearly unaffected in nickel binding compared to non-treated sample, suggesting the absence of thiolate ligands to the metal...
December 21, 2016: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28001383/luminescent-lanthanide-cyclen-based-enzymatic-assay-capable-of-diagnosing-the-onset-of-catheter-associated-urinary-tract-infections-both-in-solution-and-within-polymeric-hydrogels
#19
Esther M Surender, Samuel J Bradberry, Sandra A Bright, Colin P McCoy, D Clive Williams, Thorfinnur Gunnlaugsson
Herein we present a supramolecular (delayed luminescent) Eu(III)-based pH-responsive probe/sensor with the ability to detect the urease-mediated hydrolysis of urea in aqueous solution. A series of photophysical titrations show this Eu(III) chelate behaves as an "on-off" luminescent switching probe, with its luminescence being quenched upon urea being enzymatically converted into ammonia and carbon dioxide. Calculation of the rate constant (k) and activation energy (Ea) for this hydrolysis reaction are detailed; the results demonstrate a direct observation of enzymatic activity in solution by the sensor...
December 21, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27999644/comparison-of-levofloxacin-versus-clarithromycin-efficacy-in-the-eradication-of-helicobacter-pylori-infection
#20
Ali Akbar Haji-Aghamohammadi, Ali Bastani, Arash Miroliaee, Sonia Oveisi, Saeed Safarnezhad
BACKGROUND: Helicobacter pylori (H.pylori) infection causes multiple upper gastrointestinal diseases but optimal therapeutic regimen which can eradicate infection in all the cases has not yet been defined. This study was designed to evaluate the efficacy of triple levofloxacin-based versus clarithromycin-based therapy. METHODS: In this open-label randomized clinical trial study 120 patients who had esophagogastroduodenoscopy (EGD) with positive rapid urease test (RUT) were enrolled and divided into 2 groups...
2016: Caspian Journal of Internal Medicine
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