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https://www.readbyqxmd.com/read/29622458/usefulness-of-a-clinical-risk-score-to-predict-the-response-to-cardiac-resynchronization-therapy
#1
Rui Providencia, Eloi Marijon, Sergio Barra, Christian Reitan, Alexander Breitenstein, Pascal Defaye, Nikolaos Papageorgiou, Rudolph Duehmke, Stephan Winnik, Richard Ang, Didier Klug, Daniel Gras, Tardu Oezkartal, Oliver R Segal, Jean-Claude Deharo, Christophe Leclercq, Pier D Lambiase, Laurent Fauchier, Pierre Bordachar, Jan Steffel, Nicolas Sadoul, Olivier Piot, Rasmus Borgquist, Sharad Agarwal, Anthony Chow, Serge Boveda
BACKGROUND: Almost 1/3 of heart failure patients fail to respond to cardiac resynchronization therapy (CRT). A simple clinical score to predict who these patients are at the moment of referral or at time of implant may be of importance for early optimization of their management. METHODS: Observational study. A risk score was derived from factors associated to CRT response. The derivation cohort was composed of 1301 patients implanted with a CRT defibrillator in a multi-center French cohort-study...
June 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29596032/occurrence-and-characterization-of-carbapenemase-producing-enterobacteriaceae-in-a-tunisian-hospital
#2
Rania Ben Helal, Raoudha Dziri, Meriem Chedly, Naouel Klibi, Farouk Barguellil, Mohamed Selim El Asli, Mohamed Ben Moussa
Carbapenem-resistant Enterobacteriaceae have become of particular concern, since they were quickly disseminated in various areas in the world. The aim of the study was to investigate the prevalence of carbapenemase production among clinical isolates of Enterobacteriaceae recovered from the Military Hospital of Tunisia. Bacterial isolates (n = 125) were recovered from patients in diverse services from March 2014 to February 2016 and identified by Vitek II Compact® . The multiplex PCR for blaVIM , blaIMP , blaNDM , blaKPC , and blaOXA-48 with subsequent amplicon detection by reverse hybridization was performed with the Hyplex SuperBug ID test system (AmplexDiagnostics GmbH, Gars-Bahnhof, Germany)...
March 29, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29571839/activity-of-omadacycline-tested-against-enterobacteriaceae-causing-urinary-tract-infections-from-a-global-surveillance-program-2014
#3
M A Pfaller, P R Rhomberg, M D Huband, R K Flamm
Omadacycline is an aminomethylcycline with in vitro activity against many gram-negative pathogens. Omadacycline and comparators were tested against Enterobacteriaceae from urinary tract infections (UTIs) selected from a 2014 global surveillance program and compared to results of isolates from 2010 surveillance. The omadacycline MIC50/90 for Enterobacteriaceae collected during 2014 was 2/≥8 μg/mL (1/4 μg/mL minus Proteus, Providencia, and Morganella spp.). The MIC50/90 for E. coli was 1/2 μg/mL, similar to that in 2010 (MIC50/90 , 0...
February 24, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29566147/species-specific-mutation-rates-for-ampc-derepression-in-enterobacterales-with-chromosomally-encoded-inducible-ampc-%C3%AE-lactamase
#4
Rebekka Kohlmann, Tobias Bähr, Sören G Gatermann
Background: AmpC β-lactamases are encoded on the chromosomes of certain Enterobacterales and lead to clinical resistance to various β-lactams in case of high-level expression. In WT bacteria with inducible AmpC, the expression is low, but selection of stably ampC-derepressed mutants may occur during β-lactam therapy. Thus, for Enterobacter spp., Citrobacter freundii complex, Serratia spp. and Morganella morganii that test susceptible in vitro to oxyimino-cephalosporins, the EUCAST expert rules recommend suppressing susceptibility testing results for these agents or noting that their use in monotherapy should be discouraged, owing to the risk of selecting resistance...
March 16, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29553069/providencia-in-retail-meats-from-guangzhou-china-and-osaka-japan-prevalence-antimicrobial-resistance-and-characterization-of-classes-1-2-and-3-integrons
#5
Huiling DI, Sisi Liang, Qingyang Li, Lei Shi, Ayaka Shima, Hecheng Meng, He Yan, Shinji Yamasaki
Bacteria of the genus Providencia are opportunistic pathogens of clinical significance due to their association with diarrhea and urinary tract infections. The present study was conducted to examine the prevalence and antimicrobial resistance of Providencia spp. in retail meats sold in Guangzhou, China and Osaka, Japan. Out of 158 meat samples including beef, pork and chicken, 67 Providencia (42%) belonging to four species viz., P.alcalifaciens, P. rustigianii, P. stuartii and P. rettgeri were isolated, and most of them were resistant to tetracycline (91%) followed by ampicillin (69%) and streptomycin (49%)...
March 19, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29544919/duration-of-hospital-admission-need-of-on-demand-analgesia-and-other-peri-procedural-and-short-term-outcomes-in-sub-cutaneous-vs-transvenous-implantable-cardioverter-defibrillators
#6
Serge Boveda, Tej Elbanet Chalbia, Sophie Jacob, Stéphane Combes, Nicolas Combes, Christelle Cardin, Guillaume Laborie, Maria Joao Sousa, Zeynab Jebberi, Sophia Mzoughi, Jean-Paul Albenque, Rui Providencia
BACKGROUND: Post-procedural recovery following sub-cutaneous ICD (S-ICD) implantation is feared to be more painful and to require more prolonged hospital admission. The purpose of this study was to compare peri-procedural and short clinical outcomes of the S-ICD vs. the Transvenous ICD (TV-ICD). METHODS: We conducted a single-center cross-sectional study including all consecutive patients who underwent S-ICD implantation by the same operator since January 2016 and a gender and age-matched control group with all single chamber TV-ICD implanted patients over a contemporary time period...
May 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29541448/multidrug-resistant-gram-negative-bacterial-infections-in-a-teaching-hospital-in-ghana
#7
Nicholas Agyepong, Usha Govinden, Alex Owusu-Ofori, Sabiha Yusuf Essack
Background: Multidrug-resistant Gram-negative bacteria have emerged as major clinical and therapeutic dilemma in hospitals in Ghana.To describe the prevalence and profile of infections attributable to multidrug-resistant Gram-negative bacteria among patients at the Komfo Anokye Teaching Hospital in the Ashanti region of Ghana. Methods: Bacterial cultures were randomly selected from the microbiology laboratory from February to August, 2015. Bacterial identification and minimum inhibitory concentrations were conducted using standard microbiological techniques and the Vitek-2 automated system...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29540431/device-complications-with-addition-of-defibrillation-to-cardiac-resynchronisation-therapy-for-primary-prevention
#8
Sérgio Barra, Rui Providência, Serge Boveda, Rudolf Duehmke, Kumar Narayanan, Anthony W Chow, Olivier Piot, Didier Klug, Pascal Defaye, Daniel Gras, Jean-Claude Deharo, Paul Milliez, Antoine Da Costa, Pierre Mondoly, Jorge Gonzalez-Panizo, Christophe Leclercq, Patrick Heck, Munmohan Virdee, Nicolas Sadoul, Jean-Yves Le Heuzey, Eloi Marijon
OBJECTIVE: In patients indicated for cardiac resynchronisation therapy (CRT), the choice between a CRT-pacemaker (CRT-P) versus defibrillator (CRT-D) remains controversial and indications in this setting have not been well delineated. Apart from inappropriate therapies, which are inherent to the presence of a defibrillator, whether adding defibrillator to CRT in the primary prevention setting impacts risk of other acute and late device-related complications has not been well studied and may bear relevance for device selection...
March 14, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29511956/selective-isolation-and-characterisation-of-novel-members-of-the-family-nocardiopsaceae-and-other-actinobacteria-from-a-marine-sediment-of-tioman-island
#9
Zoe Yi Ng, Geok Yuan Annie Tan
Tioman Island is one of many sources for underexplored actinobacterial diversity in Malaysia. Selective isolation, molecular profiling, 16S rRNA gene sequencing and phylogenetic analyses were carried out to highlight the diversity of the marine actinobacterial community in a sediment collected off Tioman Island. A high number of diverse actinobacteria were recovered using skim milk/HEPES pre-treatment on a mannitol-based medium. A total of 123 actinobacterial strains were isolated, including thirty obligate marine actinobacteria putatively identified as Salinispora spp...
March 6, 2018: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29496594/bla-imp-27-on-transferable-plasmids-in-proteus-mirabilis-and-providencia-rettgeri
#10
Robert F Potter, Meghan A Wallace, Allison R McMullen, Jerome Prusa, Christina L Stallings, Carey-Ann D Burnham, Gautam Dantas
OBJECTIVES: A carbapenem resistant Providencia rettgeri (PR1) isolate was recovered from a wound infection in Missouri, USA. This isolate possessed an EDTA inhibitable carbapenemase that was unidentified using the Xpert CARBA-R assay. Our objective was to elucidate the molecular determinant of carbapenem resistance in this isolate. We then sought to test the transmissibility of blaIMP-27 loci in clinical P. rettgeri and Proteus mirabilis isolates. METHODS: In October 2016 the novel ambler Class B carbapenemase blaIMP-27 , was reported in two different Proteus mirablis (PM185 and PM187) isolates...
February 26, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29476011/porin-self-association-enables-cell-to-cell-contact-in-providencia-stuartii-floating-communities
#11
Mariam El-Khatib, Chady Nasrallah, Julie Lopes, Que-Tien Tran, Guillaume Tetreau, Hind Basbous, Daphna Fenel, Benoit Gallet, Mathilde Lethier, Jean-Michel Bolla, Jean-Marie Pagès, Michel Vivaudou, Martin Weik, Mathias Winterhalter, Jacques-Philippe Colletier
The gram-negative pathogen Providencia stuartii forms floating communities within which adjacent cells are in apparent contact, before depositing as canonical surface-attached biofilms. Because porins are the most abundant proteins in the outer membrane of gram-negative bacteria, we hypothesized that they could be involved in cell-to-cell contact and undertook a structure-function relationship study on the two porins of P. stuartii , Omp-Pst1 and Omp-Pst2. Our crystal structures reveal that these porins can self-associate through their extracellular loops, forming dimers of trimers (DOTs) that could enable cell-to-cell contact within floating communities...
February 23, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29475568/emergence-of-plasmid-mediated-colistin-resistance-mcr-1-among-enterobacteriaceae-strains-laboratory-detection-of-resistance-and-measures-to-control-its-dissemination
#12
D Lepelletier, R Bonnet, P Plésiat, M H Nicolas-Chanoine, A Berger-Carbonne, C Chidiac, B Grandbastien
The increasing use of colistin has contributed to the emergence of resistant bacteria and to an increase in the frequency of infections caused by naturally resistant Enterobacteriaceae strains such as Proteus, Providencia, Morganella, and Serratia. In August 2016, the French High Council for Public Health (French acronym HCSP) received a request from the Ministry of Health on the advice of the French National Public Health agency (Santé publique France) with regard to measures that should be taken to tackle the emergence of plasmid-mediated colistin resistance among Enterobacteriaceae strains...
February 20, 2018: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29450631/preoperative-combination-of-progressive-pneumoperitoneum-and-botulinum-toxin-type-a-in-patients-with-loss-of-domain-hernia
#13
José Bueno-Lledó, Antonio Torregrosa, Raquel Jiménez, Providencia García Pastor
INTRODUCTION: Preoperative progressive pneumoperitoneum (PPP) and botulinum toxin type A (BT) are tools in the surgical preparation of patients with loss of domain hernias (LODH). The aim of this paper is to report our experience with these preoperative techniques in 70 patients with LODH. METHODS: Observational study of 70 consecutive patients with LODH was conducted between May 2010 and May 2016. Diameters of the hernia sac, incisional hernia (VIH), and abdominal cavity (VAC) volumes, and VIH/VAC ratio were measured before and after PPP and BT, using abdominal CT scan data...
February 15, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29435240/gut-microbiota-in-the-burying-beetle-nicrophorus-vespilloides-provide-colonization-resistance-against-larval-bacterial-pathogens
#14
Yin Wang, Daniel E Rozen
Carrion beetles, Nicrophorus vespilloides, are reared on decomposing carrion where larvae are exposed to high populations of carcass-derived bacteria. Larvae do not become colonized with these bacteria but instead are colonized with the gut microbiome of their parents, suggesting that bacteria in the beetle microbiome outcompete the carcass-derived species for larval colonization. Here, we test this hypothesis and quantify the fitness consequences of colonization with different bacterial symbionts. First, we show that beetles colonized by their endogenous microbiome produce heavier broods than those colonized with carcass-bacteria...
February 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29430355/microbial-communities-associated-with-the-co-metabolism-of-free-cyanide-and-thiocyanate-under-alkaline-conditions
#15
Lukhanyo Mekuto, Seteno Karabo Obed Ntwampe, John Baptist N Mudumbi
This study focused on the identification of free cyanide (CDO) and thiocyanate (TDO) degrading microbial communities using a culture-dependent and independent approach. Culturable microbial species were isolated from the CDOs (n = 13) and TDOs (n = 18). The CDOs were largely dominated by Bacillus sp. while the TDOs were dominated by Bacillus sp., Klebsiella oxytoca, Providencia sp. and Pseudomonas sp. However, 16S rRNA amplicon gene-sequencing revealed the complexity and diversity of the microbial communities in contrast to the organisms that were detected using culture-dependent technique...
February 2018: 3 Biotech
https://www.readbyqxmd.com/read/29414043/immuno-informatics-driven-proteome-wide-investigation-revealed-novel-peptide-based-vaccine-targets-against-emerging-multiple-drug-resistant-providencia-stuartii
#16
Yelda Asad, Sajjad Ahmad, Thanyada Rungrotmongkol, Kara E Ranaghan, Syed Sikander Azam
The bacterium Providencia stuartii, is associated with urinary tract infections and is the most common cause of purple urine bag syndrome. The increasing multi-drug resistance pattern shown by the pathogen and lack of licensed vaccines make treatment of infections caused by P. stuartii challenging. As vaccinology data against the pathogen is scarce, an in silico proteome based Reverse Vaccinology (RV) protocol, in combination with subtractive proteomics is introduced in this work to screen potential vaccine candidates against P...
January 31, 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29399368/successful-treatment-of-providencia-rettgeri-cholecystitis-and-neutrophilic-cholangitis-in-a-cat
#17
Patricia L Newton, Darren R Fry
Case summary: A 15-year-old male neutered domestic shorthair cat was presented with a recent history of seizures, diarrhoea, lethargy, fever and jaundice. Marked elevation of liver enzyme activity was present and ultrasound examination was suggestive of cholecystitis and hepatitis. Neutrophilic cholangitis was confirmed on histopathology of liver biopsies. Bile culture identified a monomicrobial infection with Providencia rettgeri, which was resistant to multiple antimicrobial agents...
January 2018: JFMS Open Reports
https://www.readbyqxmd.com/read/29387810/a-novel-mapping-system-for-panoramic-mapping-of-the-left-atrium-application-to-detect-and-characterize-localized-sources-maintaining-atrial-fibrillation
#18
Shohreh Honarbakhsh, Richard J Schilling, Gurpreet Dhillon, Waqas Ullah, Emily Keating, Rui Providencia, Anthony Chow, Mark J Earley, Ross J Hunter
Objectives: This study sought to use a novel panoramic mapping system (CARTOFINDER) to detect and characterize drivers in persistent atrial fibrillation (AF). Background: Mechanisms sustaining persistent AF remain uncertain. Methods: Patients undergoing catheter ablation for persistent AF were included. A 64-pole basket catheter was used to acquire unipolar signals, which were processed by the mapping system to generate wavefront propagation maps...
January 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29364554/validation-of-a-novel-mapping-system-and-utility-for-mapping-complex-atrial-tachycardias
#19
S Honarbakhsh, R J Hunter, G Dhillon, W Ullah, E Keating, R Providencia, A Chow, M J Earley, R J Schilling
INTRODUCTION: This study sought to validate a novel wavefront mapping system utilizing whole-chamber basket catheters (CARTOFINDER, Biosense Webster). The system was validated in terms of (1) mapping atrial-paced beats and (2) mapping complex wavefront patterns in atrial tachycardia (AT). METHODS AND RESULTS: Patients undergoing catheter ablation for AT and persistent AF were included. A 64-pole-basket catheter was used to acquire unipolar signals that were processed by CARTOFINDER mapping system to generate dynamic wavefront propagation maps...
March 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29339308/antibiotic-resistance-and-virulence-traits-of-bacterial-pathogens-from-infected-freshwater-fish-labeo-rohita
#20
Dharmaraj Ramesh, Sami Souissi
Bacterial infectious diseases are a main dangerous problem in Aquaculture farming. It causes multiple diseases in fish as well as in human being and it has considerable virulence potential. In this connection, the moot of study focus to discriminate bacterial isolates recovered from naturally diseased Labeo rohita fish and their virulent characteristics. Based on the β-haemolysis factor, four isolates (KADR11, KADR12, KADR13 and KADR14) were selected for further delineation. These bacterial isolates showed high similarity with Providencia rettgeri, Aeromonas sp...
March 2018: Microbial Pathogenesis
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