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https://www.readbyqxmd.com/read/28107226/evaluation-of-a-predictive-staging-model-for-hiv-associated-kaposi-sarcoma-in-uganda
#1
Fred Okuku, Elizabeth M Krantz, James Kafeero, Moses R Kamya, Jackson Orem, Corey Casper, Warren Phipps
BACKGROUND: HIV-associated Kaposi sarcoma (KS) is commonly staged using the AIDS Clinical Trials Group criteria, which classify 3 variables-- tumor extent (T), immune status (I), and systemic symptoms (S) - into good risk (0) and poor risk (1). Although validated in the US and Europe, these criteria have not been systematically evaluated in sub-Saharan Africa (SSA), where the burden of KS is greatest. METHODS: We reviewed medical charts of adult patients with HIV-associated KS seen at the Uganda Cancer Institute from 1992-2007...
January 18, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28100630/a-multivariable-prediction-model-for-pegvisomant-dosing-monotherapy-and-in-combination-with-long-acting-somatostatin-analogues
#2
Sanne Elisabeth Franck, Tim Korevaar, Patrick Petrossians, Adrian F Daly, Philippe Chanson, Marielise Jaffrian-Rea, Thierry Brue, Günter K Stalla, Davide Carvalho, Annamaria Anita Livia Colao, Vasik Hana, Brigitte Delemer, Carmen Fajardo Montañana, A J Van der Lely, Albert Beckers, Sebastian J C M M Neggers
BACKGROUND: Effective treatment of acromegaly with pegvisomant (PEGV), a growth hormone receptor antagonist, requires an appropriate dose titration. PEGV doses vary widely among individual patients, and various covariates may affect its dosing and pharmacokinetics. OBJECTIVE: To identify predictors of the PEGV dose required to normalize insulin-like growth factor I (IGF-I) levels during PEGV monotherapy and in combination with long-acting somatostatin analogues (LA-SSAs)...
January 18, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28099479/social-contact-structures-and-time-use-patterns-in-the-manicaland-province-of-zimbabwe
#3
Alessia Melegaro, Emanuele Del Fava, Piero Poletti, Stefano Merler, Constance Nyamukapa, John Williams, Simon Gregson, Piero Manfredi
BACKGROUND: Patterns of person-to-person contacts relevant for infectious diseases transmission are still poorly quantified in Sub-Saharan Africa (SSA), where socio-demographic structures and behavioral attitudes are expected to be different from those of more developed countries. METHODS AND FINDINGS: We conducted a diary-based survey on daily contacts and time-use of individuals of different ages in one rural and one peri-urban site of Manicaland, Zimbabwe. A total of 2,490 diaries were collected and used to derive age-structured contact matrices, to analyze time spent by individuals in different settings, and to identify the key determinants of individuals' mixing patterns...
2017: PloS One
https://www.readbyqxmd.com/read/28090046/an-isolated-case-of-late-onset-amyloidogenic-transthyretin-type-familial-amyloid-polyneuropathy-associated-with-a-mutant-transthyretin-substituting-methionine-for-valine-at-position-30-showing-latent-progressive-cardiac-involvement-confirmed-by-serial-annual
#4
Chikako Sato, Tomofumi Takaya, Shumpei Mori, Kohei Hasegawa, Fumitaka Soga, Hidekazu Tanaka, Yoshiaki Watanabe, Tatsuya Nishii, Atsushi K Kono, Yukiko Morinaga, Hatsue Ishibashi-Ueda, Ken-Ichi Hirata
Late-onset amyloidogenic transthyretin (ATTR) type familial amyloid polyneuropathy (FAP) shows features distinct from those of early-onset hereditary ATTR type FAP. We herein describe an asymptomatic 68-year-old man with late-onset ATTR type FAP whose serial annual electrocardiograms demonstrated progressive left bundle branch block. Latent but severe cardiac involvement seems to be one feature of late-onset ATTR type FAP, similar to senile systemic amyloidosis (SSA). Early differential diagnosis of late-onset ATTR type FAP from SSA is important because, currently, only the former has new therapeutic options available in Japan...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28078114/colorectal-cancer-anatomic-distribution-patterns-remain-the-same-after-sessile-serrated-adenoma-polyp-considered-cancer-precursor-a-9-year-comparison-study-from-community-based-endoscopy-centers
#5
Juliana F Yang, Amy E Noffsinger, Deepak Agrawal, Qing-Hua Yang
BACKGROUND: The overall incidence of colorectal cancer (CRC) in the United States has steadily decreased. However, the incidence of right-sided CRC remains unchanged for the past two decades. The serrated neoplastic pathway (sessile serrated adenoma/polyp, SSA/P) has been considered an important pathway of colorectal carcinogenesis, especially in the right-sided CRC. The aim of this study was to compare CRC anatomic distribution patterns in a 9-year interval in the general population before and after SSA/P was recognized and treated as a CRC precursor...
December 2016: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28076899/genome-wide-association-analysis-reveals-genetic-heterogeneity-of-sj%C3%A3-gren-s-syndrome-according-to-ancestry
#6
Kimberly E Taylor, Quenna Wong, David M Levine, Caitlin McHugh, Cathy Laurie, Kimberly Doheny, Mi Y Lam, Alan N Baer, Stephen Challacombe, Hector Lanfranchi, Morten Schiødt, M Srinivasan, Hisanori Umehara, Frederick B Vivino, Yan Zhao, Stephen Shiboski, Troy E Daniels, John S Greenspan, Caroline H Shiboski, Lindsey A Criswell
OBJECTIVE: Sjögren's Syndrome (SS) is a systemic autoimmune disease affecting primarily the lacrimal and salivary glands. The Sjögren's International Collaborative Clinical Alliance (SICCA) is an international multisite observational study whose participants have been genotyped on the Omni 2.5M platform and undergone deep phenotyping using common protocol-directed methods, providing a unique opportunity to examine the genetic etiology of SS across ancestry and disease subsets. METHODS: We perform GWAS analyses utilizing dbGaP controls on all subjects (1405 cases, 1622 SICCA controls, 3125 external controls), European (similarly 585, 966, 2580), and Asian (similarly 460, 224, 901) with ancestry adjustments via principal component analyses...
January 11, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28074215/-management-of-dysphagia-in-acute-stroke-a%C3%A2-prospective-study-for-validation-of-current-recommendations
#7
B Lindner-Pfleghar, H Neugebauer, S Stösser, J Kassubek, A Ludolph, R Dziewas, M Prosiegel, A Riecker
BACKGROUND: The German expert recommendations on the management of dysphagia in patients after acute stroke suggest an algorithm for clinical and technical investigations to identify patients at risk for aspiration and thus reduce the rate of aspiration pneumonia. The effectiveness of this algorithm has, however, not yet been prospectively validated . METHODS: In this study 144 consecutive stroke patients were assessed by a full bedside swallowing assessment including the screening procedures of standardized swallowing assessment (SSA) and 2 out of 6...
January 10, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/28067703/anesthesia-for-ambulatory-pediatric-surgery-in-sub-saharan-africa-a-pilot-study-in-burkina-faso
#8
Yvette B Kabré, Idriss S S Traoré, Flavien A R Kaboré, Bertille Ki, Alain I Traoré, Isso Ouédraogo, Emile Bandré, Albert Wandaogo, Nazinigouba Ouédraogo
BACKGROUND: Long surgical wait times and limited hospital capacity are common obstacles to surgical care in many countries in Sub-Saharan Africa (SSA). Introducing ambulatory surgery might contribute to a solution to these problems. The purpose of this study was to evaluate the safety and feasibility of introducing ambulatory surgery into a pediatric hospital in SSA. METHODS: This is a cross-sectional descriptive study that took place over 6 months. It includes all patients assigned to undergo ambulatory surgery in the Pediatric University Hospital in Ouagadougou, Burkina Faso...
February 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28061822/cardiovascular-risk-and-endothelial-function-in-people-living-with-hiv-aids-design-of-the-multi-site-longitudinal-endoafrica-study-in-the-western-cape-province-of-south-africa
#9
Hans Strijdom, Patrick De Boever, Gerhard Walzl, M Faadiel Essop, Tim S Nawrot, Ingrid Webster, Corli Westcott, Nyiko Mashele, Frans Everson, Stephanus T Malherbe, Kim Stanley, Harald H Kessler, Evelyn Stelzl, Nandu Goswami
BACKGROUND: There is growing evidence of an interaction between HIV-infection, anti-retroviral therapy (ART) and cardiovascular diseases (CVD). Epidemiological studies in Europe and North America have been observing a shift towards an increased incidence of coronary heart disease and acute myocardial infarctions in HIV-infected populations compared to the general population even after adjusting for traditional cardiovascular risk factors. Despite South Africa (and sub-Saharan Africa, SSA) being regarded as the epicentre of the global HIV epidemic, very little is known about the prevalence of cardiovascular risk factors and precursors of vascular disease in HIV-infected populations in this region...
January 7, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28057714/elevated-il-37-il-18-and-il-18bp-serum-concentrations-in-patients-with-primary-sj%C3%A3-gren-s-syndrome
#10
Wang Liuqing, Xia Liping, Shen Hui, Lu Jing
The objectives of this study were to examine the serum levels of interleukin (IL)-37 and its clinical association in patients with primary Sjögren's syndrome (pSS) and to investigate whether or not IL-37 participates in the regulation of the pathogenesis of pSS. ELISA was used to analyse the serum levels of IL-37, total IL-18 and IL-18 binding protein (IL-18BP). The level of free IL-18 was calculated based on the mass action law. The correlations between the IL-37 serum levels with the laboratory values and the total IL-18 and IL-18BP serum levels were analyzed by a Spearman's correlation test...
January 5, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28052292/evaluation-for-the-clinical-efficacy-of-colon-capsule-endoscopy-in-the-detection-of-laterally-spreading-tumors
#11
Atsushi Igawa, Shiro Oka, Shinji Tanaka, Ichiro Otani, Sayoko Kunihara, Kazuaki Chayama
BACKGROUND AND AIM: The manner in which colorectal lesions are being detected with PillCam COLON2 capsule endoscopy (CCE2) has markedly improved in recent days. However, limited data are available on CCE2 for detecting laterally spreading tumors (LSTs). The aim of this study was to compare CCE2 with optical colonoscopy (OC), which is currently the gold standard used in the detection of LSTs. METHODS: We performed a prospective, single-academic center study comparing CCE2 with OC in patients with LSTs diagnosed using OC, which was performed during the 3-month period prior to CCE2...
2017: Digestion
https://www.readbyqxmd.com/read/28051234/neonatal-lupus-erythematosus-with-congenital-heart-block-in-twins
#12
Lamia Gargouri, Faiza Safi, Bayen Maalej, Souad Mallek, Fatma Turki, Imen Majdoub, Malek Akrout, Dorra Abid, Samir Kamoun, Abdelmajid Mahfoudh
Background - Neonatal lupus erythematosus is an uncommon acquired autoimmune disease caused by transplacental passage of maternal antibodies SSA/Ro, SSB/La or U1 ribonucleoproteins. The most common clinical manifestations are skin rash, cardiac lesions, thrombocytopenia, anemia and hepatosplenomegaly. Complete congenital heart block is usually irreversible needing a pacemaker implantation in two-thirds of cases. Cases report - We report neonatal lupus erythematosus with complete congenital heart block in twins...
July 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/28049394/coexistence-of-amyloidosis-and-primary-sj%C3%A3-gren-s-syndrome-an-overview-amyloidosis-and-sj%C3%A3-gren-s-syndrome
#13
Gabriela Hernandez-Molina, David Faz-Muñoz, Miguel Astudillo-Angel, Alejandra Iturralde-Chávez, Edgardo Reyes
BACKGROUND: The association of primary Sjögren´s syndrome (SS) and amyloidosis has been recognized but scarcely assessed. OBJECTIVE: Herein we analyzed the literature regarding this association in order to describe a SS phenotype prone to both conditions. METHODS: PubMed and CINAHL databases were searched from inception until April 2016 for the key words: amyloidosis, amyloid, Sjögren's syndrome and their combinations. RESULTS: Most of the cases corresponded to localized amyloidosis mainly at skin and lung, whereas only three cases were systemic...
January 3, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28038683/the-gut-microbiota-in-conventional-and-serrated-precursors-of-colorectal-cancer
#14
Brandilyn A Peters, Christine Dominianni, Jean A Shapiro, Timothy R Church, Jing Wu, George Miller, Elizabeth Yuen, Hal Freiman, Ian Lustbader, James Salik, Charles Friedlander, Richard B Hayes, Jiyoung Ahn
BACKGROUND: Colorectal cancer is a heterogeneous disease arising from at least two precursors-the conventional adenoma (CA) and the serrated polyp. We and others have previously shown a relationship between the human gut microbiota and colorectal cancer; however, its relationship to the different early precursors of colorectal cancer is understudied. We tested, for the first time, the relationship of the gut microbiota to specific colorectal polyp types. RESULTS: Gut microbiota were assessed in 540 colonoscopy-screened adults by 16S rRNA gene sequencing of stool samples...
December 30, 2016: Microbiome
https://www.readbyqxmd.com/read/28035250/from-traditional-serrated-adenoma-to-tubulovillous-adenoma-and-beyond
#15
REVIEW
Sangeetha N Kalimuthu, Adeline Chelliah, Runjan Chetty
It is well established that colorectal cancer develops from a series of precursor epithelial polyps, including tubular adenomas, villous/tubulovillous adenomas (VA/TVA), sessile serrated adenomas (SSA) and traditional serrated adenomas (TSA). Of these, TSAs are least common and account for only 5% of all serrated polyps. TSAs are characterised by the presence of a "pinecone-like" architecture, granular eosinophilic cytoplasm, luminal serrations, ectopic crypt foci (ECF) and elongated, pencillate nuclei. However, the distinct slit-like luminal serrations, reminiscent of small bowel mucosa, appear to be the most unique and reproducible feature to distinguish TSAs from other polyps...
December 15, 2016: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28034546/atmospheric-aerosol-radiative-forcing-over-a-semi-continental-location-tripura-in-north-east-india-model-results-and-ground-observations
#16
Pranab Dhar, Barin Kumar De, Trisanu Banik, Mukunda M Gogoi, S Suresh Babu, Anirban Guha
Northeast India (NEI) is located within the boundary of the great Himalayas in the north and the Bay of Bengal (BoB) in the southwest, experiences the mixed influence of the westerly dust advection from the Indian desert, anthropogenic aerosols from the highly polluted Indo-Gangetic Plains (IGP) and marine aerosols from BoB. The present study deals with the estimation and characterization of aerosol radiative forcing over a semi-continental site Tripura, which is a strategic location in the western part of NEI having close proximity to the outflow of the IGP...
December 26, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/28024501/-effect-of-rabbit-anti-human-thymocyte-immunoglobulin-combined-with-cyclosporin-a-on-severe-aplastic-anemia
#17
Wei Luo, Lin-Hua Ji, Hui Geng, Xiao-Jing Ma, Hua Xiong, Qi-Chao Yin, Jie Ma
OBJECTIVE: To study the efficacy and safety of anti-human thymocyte immunoglobulin(ATG-F) combined with cyclosporin A(CsA) on patients with severe aplastic anemia (SSA), so as to provide support for clinical work. METHODS: From January 2010 to December 2015, 78 patients with SAA admitted in our hospital were divided into 2 groups: ATG-F+CsA group(40 cases) and ATG-F group(38 cases). After treatment for 6 months, the effective rate, side reaction rate and time of effect initiation were compared between 2 groups...
December 2016: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/28018308/natural-and-synthetic-variants-of-the-tricarboxylic-acid-cycle-in-cyanobacteria-introduction-of-the-gaba-shunt-into-synechococcus-sp-pcc-7002
#18
Shuyi Zhang, Xiao Qian, Shannon Chang, G C Dismukes, Donald A Bryant
For nearly half a century, it was believed that cyanobacteria had an incomplete tricarboxylic acid (TCA) cycle, because 2-oxoglutarate dehydrogenase (2-OGDH) was missing. Recently, a bypass route via succinic semialdehyde (SSA), which utilizes 2-oxoglutarate decarboxylase (OgdA) and succinic semialdehyde dehydrogenase (SsaD) to convert 2-oxoglutarate (2-OG) into succinate, was identified, thus completing the TCA cycle in most cyanobacteria. In addition to the recently characterized glyoxylate shunt that occurs in a few of cyanobacteria, the existence of a third variant of the TCA cycle connecting these metabolites, the γ-aminobutyric acid (GABA) shunt, was considered to be ambiguous because the GABA aminotransferase is missing in many cyanobacteria...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28012848/detection-of-sessile-serrated-adenomas-in-proximal-colon-using-wide-field-fluorescence-endoscopy
#19
Bishnu P Joshi, Zhenzhen Dai, Zhenghong Gao, Jeong Hoon Lee, Navin Ghimire, Jing Chen, Anoop Prabhu, Erik J Wamsteker, Richard S Kwon, Grace H Elta, Elena M Stoffel, Asha Pant, Tonya Kaltenbach, Roy M Soetikno, Henry D Appelman, Rork Kuick, D Kim Turgeon, Thomas D Wang
BACKGROUND & AIMS: Many cancers in the proximal colon develop via from sessile serrated adenomas (SSAs), which have flat, subtle features that are difficult to detect with conventional white-light colonoscopy. Many SSA cells have the V600E mutation in BRAF. We investigated whether this feature could be used with imaging methods to detect SSAs in patients. METHODS: We used phage display to identify a peptide that binds specifically to SSAs, using subtractive hybridization with HT29 colorectal cancer cells containing the V600E mutation in BRAF and Hs738...
December 21, 2016: Gastroenterology
https://www.readbyqxmd.com/read/28010148/bone-health-of-the-ovahimba-people-of-north-western-namibia-in-the-context-of-urbanization-and-a-change-of-the-sociocultural-environment
#20
Anneke Wilhelm, Peyman Hadji, Mark Münzel, Hanna Daniel, Stephan Flache, Peter Nyarango, Peter Herbert Kann
The prevalence of osteoporosis in Sub-Saharan African (SSA) countries is low, however, as urbanization takes root, it is predicted that bone health will decrease dramatically. The bone health of the semi-nomadic Ovahimba people of Namibia was investigated in the context of urbanization and changes of the sociocultural environment. Furthermore, data on bone health in SSA countries is scarce; there exists no ethnic-specific reference group for people of black origin. Included in the study were 98 urban and rural living Ovahimba people...
December 23, 2016: Gynecological Endocrinology
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