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https://www.readbyqxmd.com/read/28806724/one-star-rating-for-a-five-star-program-evaluating-hospital-compare
#1
J M Shapiro
OBJECTIVES: For healthcare systems of any size, it is important to minimize costs while maximizing outcomes. One idea of how to achieve these goals has been the reduction in hospital-related complications, including infection and surgical complications, among others. In the United States, policy makers recently adopted the 'Hospital Compare' program as a way to encourage consumers and improve hospitals. This article evaluates the effectiveness of this policy. STUDY DESIGN: This article uses an observed cohort study of most US hospitals across four different indices...
August 11, 2017: Public Health
https://www.readbyqxmd.com/read/28806704/chiral-pharmaceuticals-a-review-on-their-environmental-occurrence-and-fate-processes
#2
REVIEW
Edmond Sanganyado, Zhijiang Lu, Qiuguo Fu, Daniel Schlenk, Jay Gan
More than 50% of pharmaceuticals in current use are chiral compounds. Enantiomers of the same pharmaceutical have identical physicochemical properties, but may exhibit differences in pharmacokinetics, pharmacodynamics and toxicity. The advancement in separation and detection methods has made it possible to analyze trace amounts of chiral compounds in environmental media. As a result, interest on chiral analysis and evaluation of stereoselectivity in environmental occurrence, phase distribution and degradation of chiral pharmaceuticals has grown substantially in recent years...
August 5, 2017: Water Research
https://www.readbyqxmd.com/read/28806366/african-american-veterans-storytelling-a-multisite-randomized-trial-to-improve-hypertension
#3
Thomas K Houston, Gemmae M Fix, Stephanie L Shimada, Judith A Long, Howard S Gordon, Charlene Pope, Julie Volkman, Jeroan J Allison, Kathryn DeLaughter, Michelle Orner, Barbara G Bokhour
BACKGROUND: Disparities in hypertension control persist for African American Veterans. OBJECTIVE: To enhance cultural relevance of hypertension control self-management education, in a multisite, stratified randomized trial, we tested an interactive Veteran-to-Veteran storytelling digital video disk (DVD) intervention created with Veteran partners, versus an education-only DVD comparison. METHODS: At 3 VA facilities, African American Veterans with uncontrolled hypertension were randomized to storytelling DVD intervention or didactic comparison DVD and followed for 6 months...
September 2017: Medical Care
https://www.readbyqxmd.com/read/28806111/-effectiveness-of-mindfulness-based-cancer-recovery-mbcr-program-among-hungarian-cancer-patients
#4
Magda Rohánszky, Károly Berényi, Dóra Fridrik, Henriette Pusztafalvi
INTRODUCTION AND AIM: Employment of mindfulness-based programs and techniques in the treatment of cancer patients have spread exponentially in the past decade. A large number of studies have proved the effectiveness of the program in the reduction of stress symptoms, depression and anxiety, and the improvement of sleep and mood patterns. The present study was done at Firebird Foundation and examines the effectiveness of the complex, MBCR (mindfulness-based cancer recovery)-based psycho-social intervention in the treatment of cancer patients...
August 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28805417/implementing-a-cornerstone-of-culture-change-consistent-staff-assignment-in-vha-community-living-centers
#5
Sonne Lemke, Penny L Brennan, Sonya SooHoo, Kathleen K Schutte
In 2011, the Veterans Health Administration (VHA) began implementing consistent staff assignment in its nursing homes (called Community Living Centers or CLCs). Consistent assignment, a cornerstone of culture change, minimizes the number of staff who provide a resident's care. The present research assessed the level and stability of consistent assignment in units within VHA CLCs and identified unit characteristics related to implementation of this staff assignment model. Schedulers in 185 of 335 organizational units that make up VHA CLCs completed a Staffing Practices Survey...
August 2017: Psychological Services
https://www.readbyqxmd.com/read/28804803/comparison-of-sample-preparation-procedures-on-metal-loid-fractionation-patterns-in-lichens
#6
E M Kroukamp, T W Godeto, P B C Forbes
The effects of different sample preparation strategies and storage on metal(loid) fractionation trends in plant material is largely underresearched. In this study, a bulk sample of lichen Parmotrema austrosinense (Zahlbr.) Hale was analysed for its total extractable metal(loid) content by ICP-MS, and was determined to be adequately homogenous (<5% RSD) for most elements. Several subsets of this sample were prepared utilising a range of sample preservation techniques and subjected to a modified sequential extraction procedure or to total metal extraction...
August 13, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28804719/effect-of-2-bleaching-agents-with-a-content-of-high-concentrated-hydrogen-peroxide-on-stained-2-cad-cam-blocks-and-a-nanohybrid-composite-resin-an-afm-evaluation
#7
İzgen Karakaya, Esra Cengiz
The aim of this study was to evaluate color stability of 3 restorative materials, discoloration ability of different solutions, efficacy of 2 office bleaching agents, and surface roughness and topography. Sixty specimens for Clearfil Majesty Esthetic (CME), Lava Ultimate (LU), and Vita Enamic (VE) were prepared. They were immersed into 3 staining solutions for 2 weeks and then they were bleached. According to the measured L(⁎), a(⁎), and b(⁎) parameters described by CIELAB system, color changes (ΔE00), translucency parameters (TP), whiteness index values (W(⁎)), and changes in closeness to pure white (ΔW(⁎)) were calculated...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28803214/self-defensive-antibiotic-loaded-layer-by-layer-coatings-imaging-of-localized-bacterial-acidification-and-ph-triggering-of-antibiotic-release
#8
Victoria Albright, Iryna Zhuk, Yuhao Wang, Victor Selin, Betsy van de Belt-Gritter, Henk J Busscher, Henny C van der Mei, Svetlana Sukhishvili
Self-defensive antibiotic-loaded coatings have shown promise in inhibiting growth of pathogenic bacteria adhering to biomaterial implants and devices, but direct proof that their antibacterial release is triggered by bacterially-induced acidification of the immediate environment under buffered conditions remained elusive. Here, we demonstrate that Staphylococcus aureus and Escherichia coli adhering to such coatings generate highly localized acidification, even in buffered conditions, to activate pH-triggered, self-defensive antibiotic release...
August 9, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28803183/chronic-urticaria-patient-perspective-cupp-the-first-validated-tool-for-assessing-quality-of-life-in-clinical-practice
#9
Ilaria Baiardini, Fulvio Braido, Giorgia Molinengo, Marco Caminati, MariaTeresa Costantino, Antonio Cristaudo, Mariangiola Crivellaro, Silvia Mariel Ferrucci, Rosella Gallo, Veronica Giorgis, Agostina Legori, Barbara Loera, Irene Martignago, Angelo Valerio Marzano, Aldo Morrone, Roberta Parente, Aurora Parodi, Anna Parolo, Silvia Peveri, Paolo Pigatto, Anna Radice, Erminia Ridolo, Giovanni Rolla, Chiara Roncallo, Oliviero Rossi, Eleonora Savi, Gianenrico Senna, Massimo Triggiani, Giorgio Walter Canonica
BACKGROUND: There is a need for validated tools to assess health-related quality of life (HRQoL) in routine clinical practice. OBJECTIVE: The aim of this study was to validate the Chronic Urticaria Patient Perspective (CUPP) for assessment of patients with chronic urticaria (CU) in clinical practice. METHODS: A provisional CUPP was developed from candidate items identified by following an iterative process in a retrospective analysis of 249 Chronic Urticaria Quality of Life Questionnaire questionnaires...
August 9, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28802416/accuracy-of-valgus-osteotomy-using-dynamic-hip-screw
#10
Sunil G Kulkarni, G S Kulkarni, Sushrut Babhulkar, Milind G Kulkarni, Ruta M Kulkarni
BACKGROUND: Non-union of neck femur is a common but difficult situation to manage especially in young adults. There are two main options of arthroplasty or osteotomy. The aim of this study was to assess the results of intertrochanteric valgus osteotomy in non-union femoral neck fractures. PATIENTS AND METHODS: We present a study of 44 cases of neck femur non-union including untreated fractures, late presentations (more than 3 weeks), treated with compression screw, DHS...
August 2017: Injury
https://www.readbyqxmd.com/read/28802185/diagnostic-yield-and-clinical-impact-of-routine-cell-culture-for-respiratory-viruses-among-children-with-a-negative-multiplex-rt-pcr-result
#11
M AlGhounaim, Y Xiao, C Caya, J Papenburg
BACKGROUND: Polymerase chain reaction (PCR) is the reference standard for respiratory virus testing. However, cell culture may still have added value in identifying viruses not detected by PCR. OBJECTIVES: We aimed to estimate the yield and clinical impact of routine respiratory virus culture among children with a negative PCR result. STUDY DESIGN: A retrospective cohort study was performed from Jan. 2013 to Sept. 2015. Respiratory samples from hospitalized or immunocompromised patients <18years old were routinely inoculated on traditional tube cell culture monolayers if they tested negative by a PCR assay for 12 respiratory viruses...
July 29, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28802019/effects-of-ultrasound-treatment-on-physicochemical-functional-properties-and-antioxidant-activity-of-whey-protein-isolate-in-the-presence-of-calcium-lactate
#12
Zhanmei Jiang, Kun Yao, Xiangying Yuan, Zhishen Mu, Zengli Gao, Juncai Hou, Lianzhou Jiang
BACKGROUND: The aim of this study was to investigate the effects of ultrasound applied at various powers (0, 200, 400, 600 or 800 W) and for different times (20 or 40 min) on the physicochemical, functional properties and antioxidant activities of whey protein isolate (WPI) dispersions in the presence of 1.20 mmol L(-1) calcium lactate. RESULTS: Surface hydrophobicity and free sulfhydryl group of the WPI dispersions containing 1.2 mmol L(-1) calcium lactate were significantly enhanced after sonication...
August 12, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28801766/absence-of-cardiotoxicity-with-prolonged-treatment-and-large-accumulating-doses-of-pegylated-liposomal-doxorubicin
#13
N Blank, I Laskov, R Kessous, L Kogan, S Lau, I A Sebag, Walter H Gotlieb, L Rudski
BACKGROUND: Pegylated liposomal doxorubicin (PLD) is used as a second-line therapy for gynecologic cancers, with a better short-term toxicity profile compared to doxorubicin or other anthracyclines. METHODS: We screened 14 patients with recurrent gynecologic cancers, who underwent prolonged treatment with large cumulative doses of PLD for overt or subtle signs of cardiotoxicity (CTX) using standard and advanced echocardiography techniques [3D volumetric method for left ventricular ejection fraction (LVEF) and left ventricular/right ventricular global longitudinal strain]...
August 11, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28801450/genomic-analysis-of-hairy-cell-leukemia-identifies-novel-recurrent-genetic-alterations
#14
Benjamin H Durham, Bartlomiej Getta, Sascha Dietrich, Justin Taylor, Helen Won, James M Bogenberger, Sasinya Scott, Eunhee Kim, Young Rock Chung, Stephen S Chung, Jennifer Hüllein, Tatjana Walther, Lu Wang, Sydney X Lu, Christopher C Oakes, Raoul Tibes, Torsten Haferlach, Barry S Taylor, Martin S Tallman, Michael F Berger, Jae H Park, Thorsten Zenz, Omar Abdel-Wahab
Classical hairy cell leukemia (cHCL) is characterized by a near 100% frequency of the BRAFV600E mutation while ~30% of variant HCL (vHCL) have MAP2K1 mutations. However, recurrent genetic alterations cooperating with BRAFV600E or MAP2K1 mutations in HCL, as well as those in MAP2K1- wildtype vHCL, are not well defined. We therefore performed deep targeted mutational and copy number analysis of cHCL (n=53) and vHCL (n=8). The most common genetic alteration in cHCL outside of BRAFV600E was heterozygous loss of chromosome 7q, the minimally deleted region of which targeted wildtype BRAF, subdividing cHCL into those hemizygous versus heterozygous for the BRAFV600E mutation...
August 11, 2017: Blood
https://www.readbyqxmd.com/read/28801301/exploring-user-learnability-and-learning-performance-in-an-app-for-depression-usability-study
#15
Colleen Stiles-Shields, Enid Montague, Emily G Lattie, Stephen M Schueller, Mary J Kwasny, David C Mohr
BACKGROUND: Mental health apps tend to be narrow in their functioning, with their focus mostly being on tracking, management, or psychoeducation. It is unclear what capability such apps have to facilitate a change in users, particularly in terms of learning key constructs relating to behavioral interventions. Thought Challenger (CBITs, Chicago) is a skill-building app that engages users in cognitive restructuring, a core component of cognitive therapy (CT) for depression. OBJECTIVE: The purpose of this study was to evaluate the learnability and learning performance of users following initial use of Thought Challenger...
August 11, 2017: JMIR Human Factors
https://www.readbyqxmd.com/read/28801092/anterior-segment-optical-coherence-tomography-for-the-diagnosis-of-corneal-dystrophies-according-to-the-ic3d-classification
#16
REVIEW
Sebastian Siebelmann, Paula Scholz, Simon Sonnenschein, Björn Bachmann, Mario Matthaei, Claus Cursiefen, Ludwig M Heindl
Corneal dystrophies are categorized according to the International Committee for Classification of Corneal Dystrophies (IC3D) classification, and their treatment depends on the affected structures and layer of the cornea. Therefore, estimating the depth and extent of the morphological changes due to the specific dystrophy is crucial when deciding between different treatment options. Besides superficial laser treatments and penetrating keratoplasty, minimal invasive lamellar keratoplasties such as Descemet membrane endothelial keratoplasty), deep anterior lamellar keratoplasty, or Descemet stripping automated keratoplasty have become increasingly popular to exchange the specific opaque layers in dystrophic eyes...
August 8, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28801061/european-temporal-trends-in-the-use-of-lymph-node-dissection-in-patients-with-renal-cancer
#17
U Capitanio, G D Stewart, A Larcher, I Ouzaid, B Akdogan, M Roscigno, M Marszalek, P Dell'Oglio, M Salagierski, A Volpe, M C Mir, M Kriegmair, C Terrone, S D Brookman-May, F Montorsi, T Klatte
BACKGROUND: The role of lymph node dissection (LND) in renal cell carcinoma (RCC) is still under debate. We aimed to assess the utilization rates of LND over time in Europe. METHODS: A multi-institutional database of 13,581 RCC patients who underwent radical nephrectomy (RN) or nephron sparing surgery (NSS) between 1988 and 2014 was created within an European consortium. We analysed temporal trends in the frequency of LND by using Joinpoint regression. Logistic regression models were used to identify predictors of LND...
August 3, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28800826/effect-of-thyme-essential-oil-and-lactococcus-lactis-cbm21-on-the-microbiota-composition-and-quality-of-minimally-processed-lamb-s-lettuce
#18
Lorenzo Siroli, Francesca Patrignani, Diana I Serrazanetti, Pamela Vernocchi, Federica Del Chierico, Alessandra Russo, Sandra Torriani, Lorenza Putignani, Fausto Gardini, Rosalba Lanciotti
The main aim of this work was to evaluate, at pilot scale in an industrial environment, the effects of the biocontrol agent Lactococcus lactis CBM21 and thyme essential oil compared to chlorine, used in the washing step of fresh-cut lamb's lettuce, on the microbiota and its changes in relation to the time of storage. The modification of the microbial population was studied through pyrosequencing in addition to the traditional plate counts. In addition, the volatile molecule and sensory profiles were evaluated during the storage...
December 2017: Food Microbiology
https://www.readbyqxmd.com/read/28800392/coarse-grained-directed-simulation
#19
Glen M Hocky, Thomas Dannenhoffer-Lafage, Gregory A Voth
Many free-energy sampling and quantum mechanics/molecular mechanics (QM/MM) computations on protein complexes have been performed where, by necessity, a single component is studied isolated in solution while its overall configuration is kept in the complex-like state by either rigid restraints or harmonic constraints. A drawback in these studies is that the system's native fluctuations are lost, both due to the change of environment and the imposition of the extra potential. Yet, we know that having both accurate structure and fluctuations is likely crucial to achieving correct simulation estimates for the subsystem within its native larger protein complex context...
August 11, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28800306/acute-effects-of-kinesio-taping-on-pain-disability-and-back-extensor-muscle-endurance-in-patients-with-low-back-pain-caused-by-magnetic-resonance-imaging-confirmed-lumbar-disc-degeneration
#20
Nai-Jen Chang, Willy Chou, Pei-Chi Hsiao, Wen-Dien Chang, Yi-Ming Lo
BACKGROUND: Individuals with disc degeneration experience associated pain and disability. Considering its safety and affordability, Kinesio tape (KT) may be a viable treatment. However, most KT studies have demonstrated its effects in healthy adults and patients with nonspecific low back pain. The efficacy of KT in patients with disc degeneration is yet to be investigated. OBJECTIVES: To examine the acute effects of KT on patients with lumbar disc degeneration confirmed through magnetic resonance imaging...
August 4, 2017: Journal of Back and Musculoskeletal Rehabilitation
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