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https://www.readbyqxmd.com/read/29148244/real-life-experience-with-bioresorbable-polymer-everolimus-eluting-stents-is-this-an-answer-in-search-of-a-question
#1
EDITORIAL
Youssef Rahban, Carey Kimmelstiel
Stent thrombosis and clinically driven restenosis are rare in the era of newer generation DES. The Synergy bioresorbable polymer DES appears to be comparable to other durable polymer and other bioabsorbable polymer DES in terms of safety and efficacy at 1-year post implantation. Further long-term study is needed to determine the specific role of the Synergy stent and other DES with bioabsorbable polymers.
November 15, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29145993/an-absorbable-hydrogel-spray-reduces-postoperative-mediastinal-adhesions-after-congenital-heart-surgery
#2
Nahidh Hasaniya, Anees Razzouk, Jennifer Newcombe, Dana Hassneiah, Jessica Heimes, Joshua Gysbers, Timothy Martens, Leonard Bailey
BACKGROUND: Adhesions encountered during reoperative cardiac surgery can prolong operative time and increase operative risk. The purpose of this clinical study was to investigate the antiadhesion property of a synthetic bioabsorbable polymer spray after cardiac reoperations in infants. METHODS: A prospective randomized double-blinded study was designed. Forty infants requiring staged cardiac operations were randomly allocated to a study group (n = 20) or a control group (n = 20)...
November 14, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29122083/biocompatibility-and-pharmacokinetics-of-fluticasone-eluting-sinus-implant-in-a-rabbit-model
#3
Vishal S Patel, Evan Walgama, Alkis Psaltis, Francois Lavigne, Steven D Pletcher, Peter H Hwang
BACKGROUND: A novel, bioabsorbable, fibrinogen-based implant has been developed as a mucosal dressing after endoscopic sinus surgery (ESS). This implant can be formulated with fluticasone propionate (FP) for local elution of corticosteroid to reduce postoperative inflammation and promote mucosal healing. OBJECTIVE: This study investigated the biocompatibility and pharmacokinetics of the implant in a rabbit model. METHODS: Implants with and without FP were placed on both intact and demucosalized maxillary sinuses of 33 New Zealand White rabbits...
November 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29104198/-feasibility-of-super-bioabsorbable-plate-insertion-into-the-sternum-manubrium-for-sternal-closure
#4
Yumi Kando, Mutsumu Fukata, Naoko Sakagami, Hitoshi Terada
We evaluated the efficacy of our sternum closure technique. Out of the 101 patients who underwent cardiovascular surgery at our department, 36 patients underwent sternum closure using ultra-high molecular weight polyethylene tape (NT) with Super FIXSORB MX40 (SF40) insertion into the sternum manubrium (group A) and 19 patients used NT with Sterna Lock Blu (group B). None of the patients had sternum disruption. Postoperative computed tomography scan revealed comparable effect in preventing transverse and anterior-posterior sternal displacement between the 2 groups...
November 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/29103084/reinforced-staplers-for-distal-pancreatectomy
#5
Manabu Kawai, Seiko Hirono, Ken-Ichi Okada, Sohei Satoi, Hiroaki Yanagimoto, Masanori Kon, Yoshiaki Murakami, Naru Kondo, Masayuki Sho, Takahiro Akahori, Hirochika Toyama, Takumi Fukumoto, Tsutomu Fujii, Ippei Matsumoto, Hidetoshi Eguchi, Hisashi Ikoma, Yutaka Takeda, Jiro Fujimoto, Hiroki Yamaue
PURPOSE: The safety and efficacy of reinforced staplers during distal pancreatectomy (DP) remain controversial because of the small sample size. This multicenter single-arm prospective study aims to evaluate the safety and efficacy of reinforced staplers with bioabsorbable material during DP. METHODS: Between October 2014 and August 2015, 121 patients scheduled for DP were enrolled in this study at 11 institutions in Japan. The primary endpoint was the incidence of clinically relevant pancreatic fistula...
November 4, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/29098299/safety-and-effectiveness-of-a-bioabsorbable-steroid-releasing-implant-for-the-paranasal-sinus-ostia-a-randomized-clinical-trial
#6
Amber Luong, Randall A Ow, Ameet Singh, Robert L Weiss, Joseph K Han, Roland Gerencer, J Pablo Stolovitzky, James W Stambaugh, Aarthi Raman
Importance: Suboptimal outcomes of endoscopic sinus surgery (ESS) are often associated with restenosis and inflammation of frontal sinus ostia. Steroid-releasing sinus implants have been shown to maintain sinus patency by minimizing inflammation and scar tissue formation. An hourglass-shaped, bioabsorbable, steroid-releasing implant was developed to provide mechanical support and optimize drug delivery to paranasal sinus ostia. Objective: To assess the safety and efficacy of the hourglass-shaped, bioabsorbable, steroid-releasing sinus implant in improving postoperative outcomes when placed in the frontal sinus ostia (FSO) following ESS in patients with chronic rhinosinusitis (CRS)...
November 2, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29073332/numerical-methods-for-polyline-to-point-cloud-registration-with-applications-to-patient-specific-stent-reconstruction
#7
Claire Yilin Lin, Alessandro Veneziani, Lars Ruthotto
We present novel numerical methods for Polyline-to-Point-Cloud Registration and their application to patient-specific modeling of deployed coronary artery stents from image data. Patient-specific coronary stent reconstruction is an important challenge in computational hemodynamics and relevant to the design and improvement of the prostheses. It is an invaluable tool in large-scale clinical trials that computationally investigate the effect of new generations of stents on hemodynamics and eventually tissue remodeling...
October 26, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29061548/acute-performance-of-a-novel-restorative-transcatheter-aortic-valve-preclinical-results
#8
Yosuke Miyazaki, Osama I Soliman, Mohammad Abdelghani, Athanasios Katsikis, Christophe Naz, Susana Lopes, Boris Warnack, Martijn Cox, Yoshinobu Onuma, Patrick W Serruys
AIMS: The XELTIS aortic valve leaflets are made from a bioabsorbable supramolecular polymer that guides the tissue to restoring itself. It is mounted on a self-expandable nitinol frame that includes three feelers and a native leaflet clipping mechanism. We sought to investigate the acute valve performance in a preclinical setting. METHODS AND RESULTS: In 33 sheep, 26 mm XELTIS aortic valve were transapically implanted in a 23 mm native annulus. Aortography (analysable, n=28) and echocardiography (analysable, n=20) were acquired immediately after implantation of the XELTIS aortic valve to assess the acute device performance...
October 24, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29042769/bioabsorbable-self-retaining-pla-nano-sized-%C3%AE-tcp-cervical-spine-interbody-fusion-cage-in-goat-models-an-in-vivo-study
#9
Lu Cao, Qian Chen, Li-Bo Jiang, Xiao-Fan Yin, Chong Bian, Hui-Ren Wang, Yi-Qun Ma, Xiang-Qian Li, Xi-Lei Li, Jian Dong
STUDY DESIGN: This is an experimental animal study. OBJECTIVE: The objective of this study was to compare an anterior cervical discectomy and interbody fusion of a novel polylactide/nano-sized β-tricalcium phosphate (PLA/nβ-TCP) bioabsorbable self-retaining cervical fusion cage (BCFC) with an autologous bone graft and polyetheretherketone (PEEK) cages. BACKGROUND: Although PLA cervical cages have potential advantages compared with traditional materials, they are not currently routinely used in spine surgery because of undesirable effects such as the lack of osteoconductivity and osteolysis around the implant...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29026706/development-of-novel-drug-eluting-stents-for-acute-myocardial-infarction
#10
REVIEW
Doo Sun Sim, Myung Ho Jeong
Delayed arterial healing at culprit sites after drug-eluting stent (DES) placement for acute myocardial infarction (AMI) is associated with increased risk of late stent thrombosis. The Korea Acute Myocardial Infarction Registry was established in commemoration of the 50(th) anniversary of Korea Circulation Society. Between November 2005 and December 2016, more than 62,000 patients were registered from 50 primary percutaneous coronary intervention (PCI) centers in Korea. DES in AMI may be safe and effective, however, there is concern about increased stent thrombosis after DES implantation in AMI patients, requiring longer-term dual anti-platelet therapy to reduce the risk of late stent thrombosis...
September 2017: Chonnam Medical Journal
https://www.readbyqxmd.com/read/29023186/photodynamic-therapy-associated-with-a-blue-dye-papain-based-gel-and-evaluation-of-its-degradation-of-type-i-collagen-fibers
#11
Sergio Brossi Botta, Patricia Aparecida Ana, Marcela Leticia Leal Gonçalves, Kristianne Porta Santos Fernandes, Raquel Agnelli Mesquita-Ferrari, Renato de Araújo Prates, Aldo Brugnera Junior, Sandra Kalil Bussadori
OBJECTIVE: The aim of this in vitro study was to evaluate the degradation of type I collagen fibers after treatment with a papain-based gel associated with a blue dye (PapaMBlue™) for use in antimicrobial photodynamic therapy. MATERIALS AND METHODS: For such, 60 bioabsorbable membrane sponge discs were used. Group 1 was the negative control group. In groups 2, 3, and 4, the papain-based gel PapaMBlue gel was applied all over the samples for 4 min and irradiated using red laser (660 ± 10 nm) with 15, 30, and 40 J/cm(2), respectively...
October 12, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28975848/bioabsorbable-poly-l-d-lactide-96-4-scaffold-arthroplasty-regjoint%C3%A2-for-trapeziometacarpal-osteoarthritis-a-3-year-follow-up-study
#12
Simo Mattila, Mari Ainola, Eero Waris
The poly-L/D-lactide joint scaffold (RegJoint™) has recently been associated with adverse tissue reactions and osteolysis after partial trapeziectomy for trapeziometacarpal osteoarthritis. Twenty-two of 23 patients previously operated on with this scaffold were re-examined at a mean follow-up of 3.3 years (range 36-53 months). Overall, the results showed an unacceptably high rate of adverse tissue reactions related to the degradation process of the implant, resulting in a revision procedure in three patients...
January 1, 2017: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/28970994/arthroscopic-revision-of-medial-rotator-cuff-failure-augmented-with-a-bioabsorbable-patch
#13
Eduard Buess, Michael Hackl, Peter Buxbaumer
When revising failed double-row and suture-bridge rotator cuff repairs medial failures represent a potential feature. In the presence of a compromised healing environment, patch augmentation becomes a logical adjunct from a mechanical and biological point of view. A reproducible step-by-step revision technique is described that reinforces the weak central cuff area with an absorbable synthetic scaffold.
August 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28966383/transportal-anterior-cruciate-ligament-reconstruction-with-quadrupled-hamstring-tendon-graft-a-prospective-outcome-study
#14
Chandan Kumar, Anil Kumar Gupta, Santosh Kumar Singh, Rohit Jain
BACKGROUND: Anterior cruciate ligament (ACL) reconstruction has been one of the most commonly performed procedures throughout the world. Unsatisfactory outcome with conventional ACL reconstruction has been attributed to nonanatomic graft placement. Researchers have advised placing the graft in the native footprint of ACL to avoid nonanatomic graft placement. The goal of this study was to analyze the outcome of anatomic single bundle ACL reconstruction using transportal technique. MATERIALS AND METHODS: This was a prospective outcome study conducted on 85 consecutive patients of ACL reconstruction of which 62 patients met inclusion and exclusion criteria and were analyzed for final results...
September 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28945635/comparison-of-stromal-vascular-fraction-with-or-without-a-novel-bioscaffold-to-fibrin-glue-in-a-porcine-model-of-mechanically-induced-anorectal-fistula
#15
Gerald W Dryden, Eugene Boland, Vijay Yajnik, Stuart Williams
BACKGROUND: Anorectal fistulas (ARFs) are a common, devastating, event in the life of a patient with Crohn's disease. ARFs occur in up to 50% of patients with Crohn's disease. Treatment begins with surgical drainage of the initial abscess, followed by antibiotic therapy, then anti-inflammatory medications. If medical therapy fails to close the fistula tract, surgical intervention is often pursued. Surgery incurs risk of incontinence because of sphincter injury. Increasingly, the role of cell-based therapy is being investigated in ARFs...
November 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28945013/pro-regenerative-hydrogel-restores-scarless-skin-during-cutaneous-wound-healing
#16
Guoming Sun
The transformation of fibrotic healing process to regenerative one has great potential to fully restore wounded skin. The M2 macrophage phenotype promotes constructive tissue remodeling and instructs tissue repair in a regenerative manner. It is hypothesized that hydrogels that can establish robustness of endogenous cells to regulate M2 phenotype will promote constructive dermal remodeling. Toward this end, a series of dextran-based bioabsorbable hydrogels are developed and self-crosslinkable dextran-isocyanatoethyl methacrylate-ethylamine (DexIEME) is identified as the potential scaffold...
September 25, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28942460/hip-arthroscopy-enables-classification-and-treatment-of-precollapse-subchondral-insufficiency-fracture-of-the-femoral-head-associated-intra-articular-pathology
#17
Soshi Uchida, Moriyuki Noguchi, Hajime Utsunomiya, Shiho Kanezaki, Toshiharu Mori, Dean K Matsuda, Akinori Sakai
PURPOSE: The purposes of this study were to investigate (1) the clinical, radiographic and arthroscopic presentation of patients with subchondral insufficiency fracture of the femoral head (SIFFH) and (2) the outcomes following arthroscopic treatment with internal fixation using hydroxyapatite poly-lactate acid (HA/PLLA) threaded pins and concomitant arthroscopic treatment of associated findings. METHODS: Nine patients (median age 49.0 years, range 43-65, five female and four male patients) with SIFFH who underwent arthroscopic treatment with labral repair, capsular closure and internal fixation of SIFFH using HA/PLLA pins were retrospectively reviewed...
September 23, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28938197/a-collagen-membrane-containing-osteogenic-protein-1-facilitates-bone-regeneration-in-a-rat-mandibular-bone-defect
#18
Manami Ozaki, Tadahiro Takayama, Takanobu Yamamoto, Yasumasa Ozawa, Mayu Nagao, Natsuko Tanabe, Akira Nakajima, Naoto Suzuki, Masao Maeno, Seiichi Yamano, Shuichi Sato
OBJECTIVES: Osteogenic protein-1 (OP-1) has shown osteoinductive activities and is useful for clinical treatments, including bone regeneration. Regenerative procedures using a bioabsorbable collagen membrane (BCM) are well established in periodontal and implant dentistry. We evaluated the subsequent effects of the BCM in combination with OP-1 on bone regeneration in a rat mandibular circular critical-sized bone defect in vivo. DESIGN: We used 8 rats that received surgery in both sides of the mandible, and created the total 16 defects which were divided into 4 groups: Group 1; no treatment, as a control, Group 2; BCM alone, Group 3; BCM containing low dose 0...
September 8, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28933641/the-effect-of-a-silk-fibroin-polyurethane-blend-patch-on-rat-vessels
#19
Kazumi Shimada, Akira Higuchi, Ryota Kubo, Tomoaki Murakami, Yasumoto Nakazawa, Ryou Tanaka
Patch grafts are widely used in various kind of vascular surgeries such as detect repair or dilation of vascular stenosis. Expanded polytetrafluoroethylene (ePTFE) patches are flexible and handle well, but have shown problems with calcification as they are non-bioabsorbable and therefore permanently remain in the body. It is important to develop an alternative biocompatible patch. Silk fibroin (SF) was developed as a biocompatible material, but it lacks of the elasticity required for surgery as a patch. Polyurethane (PU) is also a well-known elastomer so this study focused on the SF and the PU blend materials with a weight ratio of 5:5 (SF/PU)...
October 2, 2017: Organogenesis
https://www.readbyqxmd.com/read/28931346/subhepatic-mass-occurrence-after-using-oxidized-and-regenerated-cellulose-polymer-in-laparoscopic-cholecystectomy-a-case-series
#20
Erasmo Spaziani, Annalisa Di Filippo, Piero Francioni, Martina Spaziani, Alessandro De Cesare, Marcello Picchio
BACKGROUND: Oxidized regenerated cellulose (ORC) is a bioabsorbable surgical hemostatic. We present the first prospective case series of circumscribed mass occurrence after using ORC in laparoscopic cholecystectomy. METHODS: Tabotamp (Ethicon, Inc., Somerville, NJ) in the form of tightly woven knitted patches was used to achieve hemostasis in 83 patients submitted to LC. RESULTS: A subhepatic mass was detected in five patients and radiologic characteristics were described...
September 20, 2017: Acta Chirurgica Belgica
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