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https://www.readbyqxmd.com/read/28433790/a-strain-mediated-corrosion-model-for-bioabsorbable-metallic-stents
#1
E Galvin, D O'Brien, C Cummins, B J Mac Donald, C Lally
This paper presents a strain-mediated phenomenological corrosion model, based on the discrete finite element modelling method which was developed for use with the ANSYS Implicit finite element code. The corrosion model was calibrated from experimental data and used to simulate the corrosion performance of a WE43 magnesium alloy stent. The model was found to be capable of predicting the experimentally observed plastic strain-mediated mass loss profile. The non-linear plastic strain model, extrapolated from the experimental data, was also found to adequately capture the corrosion-induced reduction in the radial stiffness of the stent over time...
April 19, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28408988/sutureless-functional-end-to-end-anastomosis-using-a-linear-stapler-with-polyglycolic-acid-felt-for-intestinal-anastomoses
#2
Masanori Naito, Hirohisa Miura, Takatoshi Nakamura, Takeo Sato, Takahiro Yamanashi, Atsuko Tsutsui, Masahiko Watanabe
BACKGROUND: Gastrointestinal anastomosis remains associated with a considerable burden of morbidity and, in some cases, mortality. Functional end-to-end anastomosis, whilst extremely efficient, is vulnerable to increased intestinal pressure in the immediate postoperative period, which may predispose to development of anastomotic leakage or bleeding. Therefore, there is a requirement for new techniques that facilitate safe and efficacious anastomotic procedures. MATERIALS AND METHODS: This study examined the clinical application of functional end-to-end anastomosis with a stapler that automatically applies a bioabsorbable polyglycolic acid sheet (Endo GIA™ Reinforced Reload with Tri-Staple™ Technology)...
May 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28408260/evaluation-of-bioabsorbable-multiamino-acid-copolymer-nano-hydroxyapatite-calcium-sulphate-cage-in-a-goat-spine-model
#3
Chunpeng Ren, Yueming Song, Youdi Xue, Xi Yang, Chunguang Zhou
BACKGROUND: Recently, polylactide is the most popular material used to made bioabsorbable cages, but too fast degradation and osteolysis around the cage have been reported in the literature. This study evaluated the fusion effect, biomechanical stability and histological characteristics of a novel bioabsorbable multi-amino acid copolymer/nano-hydroxyapatite/calcium sulphate (MAACP/n-HA/CS) interbody cage in a goat model of anterior cervical discectomy and fusion (ACDF). METHODS: A total of 24 goats underwent C3/C4 discectomy and fusion with three groups of intervertebral implants: MAACP/n-HA/CS cage group (n = 8), titanium cage group (n = 8) and autologous tricortical iliac crest bone group (n = 8)...
April 10, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28400193/autologous-mesenchymal-stem-cells-applied-in-a-bioabsorbable-matrix-for-treatment-of-perianal-fistulas-in-patients-with-crohn-s-disease
#4
Allan B Dietz, Eric J Dozois, Joel G Fletcher, Greg W Butler, Darcie Radel, Amy L Lightner, Maneesh Dave, Jessica Friton, Asha Nair, Emily T Camilleri, Amel Dudakovic, Andre J van Wijnen, William A Faubion
In patients with Crohn's disease (CD), perianal fistulas frequently recur, causing substantial morbidity. We performed a 12 patient, 6 month phase I trial to determine whether autologous mesenchymal stem cells (MSCs), applied in a bioabsorbable matrix, can heal the fistula. Fistula repair was not associated with any serious adverse events related to MSCs or plug placement. At 6 months, 10/12 patients (83%) had complete clinical healing and radiographic markers of response. We found placement of MSC-coated matrix fistula plugs in 12 patients with chronic perianal fistulas to be safe and lead to clinical healing and radiographic response in 10 patients...
April 8, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28385909/delayed-presentation-of-button-battery-ingestion-a-devastating-complication
#5
Robert Chessman, Misha Verkerk, Richard Hewitt, Nneka Eze
A 12-month-old child presented with a prolonged history of fever, cough and difficulty breathing, which was initially treated as bronchiolitis. She was discharged but presented again to Accident and Emergency department 4 days later with worsening symptom. Following deterioration in the Emergency department, a chest X-ray revealed a button battery in the upper oesophagus. Emergency oesophagoscopy was performed where a 20 mm button battery was removed and a tracheoesophageal fistula was seen 12 mm above the carina...
April 6, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28373453/linear-stapling-device-with-pre-attached-bioabsorbable-polyglycolic-acid-felt-reduces-postoperative-pancreatic-fistula-after-distal-pancreatectomy
#6
Yo-Ichi Yamashita, Eiji Tsujita, Akira Chikamoto, Katsunori Imai, Takayoshi Kaida, Takanobu Yamao, Naoki Umezaki, Shigeki Nakagawa, Daisuke Hashimoto, Hideo Baba
The incidence of postoperative pancreatic fistula (POPF) remains high at approximately 30% of cases with distal pancreatectomy (DP) and is associated with higher incidence of life-threatening complications. However, the most appropriate closure technique for the pancreatic stump during DP remains controversial. We, herein, present details of the use of a linear stapling device with pre-attached bioabsorbable polyglycolic acid (PGA) felt for pancreatic stump closure during DP. Grade B or C POPF occurred in only one case (5%) among 22 consecutive patients...
April 2017: Anticancer Research
https://www.readbyqxmd.com/read/28368929/outcomes-after-arthroscopic-fixation-of-tibial-eminence-fractures-with-bioabsorbable-nails-in-skeletally-immature-patients
#7
Amit M Momaya, Connor Read, Megan Steirer, Reed Estes
The aim of this paper is to report the outcomes and any complications with arthroscopic bioabsorbable nail fixation of tibial eminence fractures in skeletally immature patients. We retrospectively reviewed all surgically treated tibial eminence fractures treated by a single surgeon and seven patients were identified with a minimum 2-year follow-up. Mean deficits of flexion and extension were minimal. Satisfactory Tegner levels, Lysholm knee scores, and International Knee Documentation Committee subjective scores were reported...
March 31, 2017: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/28357714/the-role-for-cardiovascular-remodeling-in-cardiovascular-outcomes
#8
REVIEW
Nishant Krishna Sekaran, Anna Lisa Crowley, Fernanda Rodrigues de Souza, Elmiro Santos Resende, Sunil V Rao
PURPOSE OF REVIEW: Ischemic and non-ischemic injury to the heart causes deleterious changes in ventricular size, shape, and function. This adverse remodeling is mediated by neurohormonal and hemodynamic alterations and is reflected in non-invasive measures of left ventricular ejection fraction (LVEF), left ventricular end-systolic volume (LVESV), and left ventricular end-diastolic volume (LVEDV). These measures are closely linked to cardiovascular outcomes and have become key surrogate endpoints for evaluating the therapeutic efficacy of contemporary treatments for heart failure with reduced ejection fraction (HFrEF)...
May 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/28344529/clinical-evaluation-after-peripheral-nerve-repair-with-caprolactone-neurotube
#9
Gabriel Costa Serrão de Araújo, Bernardo Couto Neto, Renato Harley Santos Botelho, Marcio Carpi Malta
Background: Peripheral nerve injuries with substance loss are challenges to surgeons because direct suture repair may result in malfunction due to nerve suture tension. Autologous nerve grafts are alternatives for treating those lesions; however, harvesting grafts adds morbidity at donor sites. Synthetic substitutes are options to bridge the gaps in these situations. The caprolactone neurotubes are used to assist nerve regeneration, but the literature lacks studies that evaluate their results. Methods: This research was designed to clinically evaluate patients undergoing repair of peripheral nerves with that conduit...
March 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28314534/total-cavopulmonary-connection-with-a-new-bioabsorbable-vascular-graft-first-clinical-experience
#10
Leo A Bockeria, Oleg Svanidze, Alex Kim, Konstantin Shatalov, Vladimir Makarenko, Martijn Cox, Thierry Carrel
OBJECTIVES: To assess safety and clinical performance of a novel bioabsorbable vascular graft in pediatric patients with univentricular cardiac malformation who received surgical correction via an extracardiac cavopulmonary conduit. METHODS: The implanted graft material is designed to attract patient's own cells and proteins, which trigger a cascade of physiological events leading to endogenous tissue restoration. As the graft resorbs progressively after implantation, components of native tissue including collagen, endothelial lining, and capillary blood vessels develop and organize into a natural tissue...
February 7, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28284833/electrospun-starch-nanofibers-recent-advances-challenges-and-strategies-for-potential-pharmaceutical-applications
#11
REVIEW
Guodong Liu, Zhengbiao Gu, Yan Hong, Li Cheng, Caiming Li
Electrospun starch nanofibers have high porosity, extremely high specific surface area, and biocompatible, biodegradable, and bioabsorbable properties. As a result, starch nanofibers have great potential in pharmaceutical applications, including drug delivery, wound dressing, and tissue engineering. Here, we summarize and review the recent developments in the synthesis of electrospun starch fibers from common starch, modified starch, and hybrids with other polymers. Moreover, the challenges and strategies for the fabrication and application of starch fibers in pharmaceutical applications are presented...
March 9, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28284452/advances-in-absorbable-biomaterials-and-nasal-packing
#12
REVIEW
Conner J Massey, Ameet Singh
Nasal biomaterials have been developed to improve postoperative outcomes after functional endoscopic sinus surgery (FESS). These products have been designed to overcome certain common complications in FESS, and to maximize patient comfort. This article evaluates the performance of nonabsorbable and absorbable packing with respect to these outcomes. The collected trials suggest superior performance of bioabsorbable packs compared with absorbable packs with respect to patient comfort. For hemostasis and wound healing, variation in performance metrics makes interstudy comparison difficult...
March 9, 2017: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/28275942/bioresorbable-polymers-and-stent-devices
#13
REVIEW
Payam Dehghani
Percutaneous coronary interventions will never become obsolete, as evolution is inherent to interventional cardiology. Current drug-eluting platforms have appreciably improved their safety and efficacy profiles in different clinical settings compared to first-generation devices such that it is difficult to consider other alternatives. However, there is definite biological plausibility to consider devices with bioabsorbable polymers and/or scaffolds. It is also an undeniable fact that many patients, based on variety of belief systems, would prefer not to have a permanently implanted device...
February 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28268142/an-innovative-anchoring-technique-for-anterior-transfer-of-the-tibialis-posterior-tendon
#14
Po-Chih Shen, Shih-Hsiang Chou, Jian-Chih Chen, Shu-Jung Chen, Yin-Chun Tien
Favorable results have been reported for tibialis posterior tendon transfers, which can effectively restore the dorsiflexion of the ankle and normal heel-to-toe gait. However, the commonly used methods for anchoring the transplanted tendon have some drawbacks. Therefore, we developed a new tendon-anchoring method to improve fixation of the transferred tendon and reduce the related complications. The new method entails tying the anchoring suture to the navicular bone instead of the button on the plantar foot to avoid wound complications...
March 3, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28251005/pectoralis-major-tear-with-retracted-tendon-how-to-fill-the-gap-reconstruction-with-hamstring-autograft-and-fixation-with-an-interference-screw
#15
L Baverel, K Messedi, G Piétu, V Crenn, F Gouin
Rupture of the pectoralis major tendon is considered an uncommon injury and a significant number of ruptures are missed or diagnosed late, leading to a chronic tear. We report an open reconstruction technique and its outcomes in a case of chronic and retracted PM tear. At the last follow-up (12 months), the patient was pain-free, with a visual analogic scale at 0 all the time. He was very satisfied concerning the cosmetic and clinical results. The constant score was 93%, the SST value 95%, and the Quick DASH score 4...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28237687/a-new-approach-to-improve-the-local-compressive-properties-of-ppdo-self-expandable-stent
#16
Fan Zhao, Wen Xue, Fujun Wang, Chenglong Yu, Haiyan Xu, Yi Hao, Lu Wang
The radial performance of bioabsorbable polymeric intravascular stents is extremely important in assessing the efficiency of these devices in expanding narrow lumen, reducing stent recoil, and recovering to their original states after suffering from pulsating pressure. However, these stents remain inferior to metallic stents. Several thermal treatment conditions (60°C, 80°C, and 100°C for 1h) were investigated to improve the characteristics of poly(p-dioxanone) (PPDO) self-expandable stents. The local compressive force, stiffness, and viscoelasticity of these stents were also evaluated...
February 16, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28224709/secure-overlap-stapling-using-a-linear-stapler-with-bioabsorbable-polyglycolic-acid-felt
#17
Masanori Naito, Takeo Sato, Takatoshi Nakamura, Takahiro Yamanashi, Hirohisa Miura, Atsuko Tsutsui, Masahiko Watanabe
INTRODUCTION: Despite the availability of various anastomosis techniques, postoperative anastomotic complications such as anastomosis failure and bleeding develop in some patients. Automatic suturing devices have been widely used for gastrointestinal anastomosis. However, overly thick or thin tissue, displacement of tissue, and the creation of a staple-on-staple site may lead to incomplete staple formation. These factors are considered to be related to postoperative complications such as anastomosis failure...
February 22, 2017: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/28220461/new-generation-coronary-stents-current-data-and-future-directions
#18
REVIEW
Ankur Kalra, Hasan Rehman, Sahil Khera, Braghadheeswar Thyagarajan, Deepak L Bhatt, Neal S Kleiman, Robert W Yeh
PURPOSE OF REVIEW: Drug-eluting stents are the mainstay in the treatment of coronary artery disease using percutaneous coronary intervention. Innovations developed to overcome the limitations of prior generations of stents include biodegradable polymer stents, drug-eluting stents without a polymer, and bioabsorbable scaffolds. Our review briefly discusses the clinical profiles of first- and second-generation coronary stents, and provides an up-to-date overview of design, technology, and clinical safety and efficacy profiles of newer generation coronary stents discussing the relevant clinical trials in this rapidly evolving area of interventional cardiology...
March 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/28203605/femoral-and-tibial-tunnel-diameter-and-bioabsorbable-screw-findings-after-double-bundle-acl-reconstruction-in-5-year-clinical-and-mri-follow-up
#19
Tommi Kiekara, Antti Paakkala, Piia Suomalainen, Heini Huhtala, Timo Järvelä
BACKGROUND: Tunnel enlargement is frequently seen in short-term follow-up after anterior cruciate ligament reconstruction (ACLR). According to new evidence, tunnel enlargement may be followed by tunnel narrowing, but the long-term evolution of the tunnels is currently unknown. HYPOTHESIS/PURPOSE: The hypothesis was that tunnel enlargement is followed by tunnel narrowing caused by ossification as seen in follow-up using magnetic resonance imaging (MRI). The purpose of this study was to evaluate the ossification pattern of the tunnels, the communication of the 2 femoral and 2 tibial tunnels, and screw absorption findings in MRI...
February 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28183636/improved-tympanic-membrane-regeneration-after-myringoplastic-surgery-using-an-artificial-biograft
#20
A P S Immich, P C Pennacchi, A F Naves, S L Felisbino, R L Boemo, S S Maria-Engler, L H Catalani
Tympanic membrane perforations are due to common otologic problems. The current treatments to heal tympanic membrane perforation, such as myringoplasty, have some disadvantages, including the need for autologous grafting, which is rapidly absorbed by the organism before perforation recovery is complete. To improve the structural and functional tympanic membrane healing after surgery, we propose a new branch of artificial grafts. In this study, we report the development of artificial grafts using electrospun bioabsorbable polymers...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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