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https://www.readbyqxmd.com/read/29775604/the-use-of-stitching-and-bioabsorbable-mesh-and-glue-to-combat-prolonged-air-leaks
#1
Toshiki Tanaka, Kazuhiro Ueda, Junichi Murakami, Kimikazu Hamano
Prolonged postoperative air leaks are associated with extended periods of postoperative hospitalization, increased hospital costs, and an increased incidence of major cardiopulmonary complications. To prevent prolonged air leaks, we used small pieces of polyglycolic acid mesh as a pledget during the stitching of air leak sites. The stitched sites were then covered with mesh and fibrin glue. This novel technique showed the highest airway pressure tolerance in an ex vivo experimental study. There were no incidents of prolonged air leak among the five clinical cases in which this technique was initially applied...
May 15, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29761272/primary-paraesophageal-hernia-repair-with-gore%C3%A2-bio-a%C3%A2-tissue-reinforcement-long-term-outcomes-and-association-of-bmi-and-recurrence
#2
Michael T Olson, Saurabh Singhal, Roshan Panchanathan, Sreeja Biswas Roy, Paul Kang, Taylor Ipsen, Sumeet K Mittal, Jasmine L Huang, Michael A Smith, Ross M Bremner
BACKGROUND: Laparoscopic repair remains the gold-standard treatment for paraesophageal hernia (PEH). We analyzed long-term symptomatic outcomes and surgical reintervention rates after primary PEH repair with onlay synthetic bioabsorbable mesh (W. L. Gore & Associates, Inc., Flagstaff, AZ) and examined body mass index (BMI) as a possible risk factor for poor outcomes and for recurrence. METHODS: We queried a prospectively maintained database to identify patients who underwent laparoscopic primary PEH repair with onlay patch of a bioprosthetic absorbable mesh (Bio-A® Gore®) between 05/28/2009 and 12/31/2013...
May 14, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29756407/a-prospective-study-for-treatment-of-nasal-valve-collapse-due-to-lateral-wall-insufficiency-outcomes-using-a-bioabsorbable-implant
#3
Pablo Stolovitzky, Douglas M Sidle, Randall A Ow, Nathan E Nachlas, Sam P Most
OBJECTIVE: To examine 6-month outcomes for treatment of lateral nasal wall insufficiency with a bioabsorbable implant. STUDY DESIGN: Prospective, multicenter, nonrandomized, single-blinded study. METHODS: One hundred and one patients with severe-to-extreme class of Nasal Obstruction Symptom Evaluation (NOSE) scores were enrolled at 14 U.S. clinics (September 2016-March 2017). Patients were treated with a bioabsorbable implant designed to support lateral wall, with or without concurrent septoplasty and/or turbinate reduction procedure(s)...
May 14, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29746890/use-of-a-capillary-alginate-gel-capgel%C3%A2-to-study-the-three-dimensional-development-of-sensory-nerves-reveals-the-formation-of-a-rudimentary-perineurium
#4
Wesley A Anderson, Alicia R Willenberg, Alexander J Bosak, Bradley J Willenberg, Stephen Lambert
BACKGROUND: Peripheral neuropathies affect approximately 20 million people in the United States and often stem from other chronic conditions, such as diabetes. In vitro methodologies to facilitate the understanding and treatment of these disorders often lack the cellular and functional complexity required to accurately model peripheral neuropathies. In particular, they are often 2D and fail to faithfully reproduce the 3D in vivo microenvironment. NEW METHOD: Embryonic dorsal root ganglion (DRG) explants were inserted into laminin derivatized capillary alginate gel (Capgel™), a bioabsorbable, self-assembling biomaterial, possessing parallel microchannel architecture, and cultured to mimic normal nerve development, including Schwann cell myelination...
May 7, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29744430/preparation-of-chitin-pla-laminated-composite-for-implantable-application
#5
Romana Nasrin, Shanta Biswas, Taslim Ur Rashid, Sanjida Afrin, Rumana Akhter Jahan, Papia Haque, Mohammed Mizanur Rahman
The present study explores the possibilities of using locally available inexpensive waste prawn shell derived chitin reinforced and bioabsorbable polylactic acid (PLA) laminated composites to develop new materials with excellent mechanical and thermal properties for implantable application such as in bone or dental implant. Chitin at different concentration (1-20% of PLA) reinforced PLA films (CTP) were fabricated by solvent casting process and laminated chitin-PLA composites (LCTP) were prepared by laminating PLA film (obtained by hot press method) with CTP also by hot press method at 160 °C...
December 2017: Bioactive Materials
https://www.readbyqxmd.com/read/29727767/bioabsorbable-plating-in-the-treatment-of-pediatric-clavicle-fractures-a-biomechanical-and-clinical-analysis
#6
Emily J Osborn, Christine L Farnsworth, Joshua D Doan, Eric W Edmonds
BACKGROUND: Classic implants for operative intervention of mid-shaft clavicle fractures in adolescents can become symptomatic, requiring removal. This study compares 1) biomechanical properties and 2) clinical outcomes in adolescents of mid-shaft clavicle fracture fixation with bioabsorbable versus metal implants. METHODS: Six synthetic clavicles with mid-shaft fractures underwent bioabsorbable plating. A testing frame applied 10 non-destructive torsion and 10 axial compression cycles, followed by cantilever bending to failure...
April 30, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29703901/cvd-grown-monolayer-mos-2-in-bioabsorbable-electronics-and-biosensors
#7
Xiang Chen, Yong Ju Park, Minpyo Kang, Seung-Kyun Kang, Jahyun Koo, Sachin M Shinde, Jiho Shin, Seunghyun Jeon, Gayoung Park, Ying Yan, Matthew R MacEwan, Wilson Z Ray, Kyung-Mi Lee, John A Rogers, Jong-Hyun Ahn
Transient electronics represents an emerging technology whose defining feature is an ability to dissolve, disintegrate or otherwise physically disappear in a controlled manner. Envisioned applications include resorbable/degradable biomedical implants, hardware-secure memory devices, and zero-impact environmental sensors. 2D materials may have essential roles in these systems due to their unique mechanical, thermal, electrical, and optical properties. Here, we study the bioabsorption of CVD-grown monolayer MoS2 , including long-term cytotoxicity and immunological biocompatibility evaluations in biofluids and tissues of live animal models...
April 27, 2018: Nature Communications
https://www.readbyqxmd.com/read/29696362/fixation-of-medial-malleolar-fractures-with-magnesium-bioabsorbable-headless-compression-screws-short-term-clinical-and-radiological-outcomes-in-eleven-patients
#8
Ozkan Kose, Adil Turan, Melih Unal, Baver Acar, Ferhat Guler
OBJECTIVE: The purpose of this retrospective study was to evaluate the outcome of medial malleolar fractures treated with magnesium (MgYREZr) bioabsorbable compression screw fixation. MATERIALS AND METHODS: Eleven patients with a medial malleolar fracture (either isolated or accompanied by bimalleolar or trimalleolar ankle fractures) who were treated with magnesium bioabsorbable compression screws between 2015 and 2016 in our hospital were retrospectively evaluated...
April 25, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29664877/juvenile-osteochondritis-dissecans-of-the-trochlea-a-cohort-study-of-34-trochlear-lesions-associated-with-sporting-activities-that-load-the-patellofemoral-joint
#9
Meghan J Price, Maria Tuca, Joseph Nguyen, Jason Silberman, Eva Luderowski, Tyler J Uppstrom, Daniel W Green
BACKGROUND: Juvenile osteochondritis dissecans (JOCD) lesions are rarely located in the trochlea and few studies have focused on the causes and outcomes of JOCD lesions in this part of the knee. The purpose of this study is to (1) evaluate the clinical characteristics and outcomes of patients who undergo surgery for JOCD in this unusual location as well as (2) assess the association between trochlear JOCD and participation in sporting activities that load the patellofemoral joint. METHODS: We conducted a retrospective cohort study of 34 trochlear JOCD lesions in 30 patients...
April 16, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29628810/rehabilitation-of-tibial-plateau-fracture-following-anterior-cruciate-ligament-reconstruction-a-case-report
#10
Ali Rabatsky, John D Lockenour
Objective: The purpose of this case report was to describe the management of a tibial plateau fracture in a patient who had undergone anterior cruciate ligament (ACL) reconstruction 3.5 years earlier. Clinical Features: A 36-year-old man presented with pain and edema following a fall from a height of approximately 2 m while skateboarding. The patient reported having undergone arthroscopic ACL reconstruction with allograft and bioabsorbable screws 3.5 years earlier...
March 2018: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/29627909/technological-advances-in-stent-therapies-a-year-in-review
#11
REVIEW
Jad Raffoul, Ammar Nasir, Andrew J P Klein
Stent technology has rapidly evolved since the first stainless steel bare metal stents with substantial developments in scaffolding, polymer, drug choice, drug delivery, and elution mechanisms. Most recently, there has been the evolution of bioabsorbable vascular scaffolds, potentially eliminating the need for long-term foreign object retention. These rapid developments have led to an ever-expanding selection of new stents, making the choice of which to use in which patient challenging. Operators must balance potential short- and long-term clinical ramifications, namely stent thrombosis, in-stent restenosis, target lesion revascularization, and target lesion failure...
April 7, 2018: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29619983/acute-thrombogenicity-of-fluoropolymer-coated-versus-biodegradable-and-polymer-free-stents
#12
Sho Torii, Qi Cheng, Hiroyoshi Mori, Michael J Lipinski, Eduardo Acampado, Laura E L Perkins, Syed F Hossainy, Stephen D Pacetti, Frank D Kolodgie, Renu Virmani, Aloke V Finn
AIMS: Durable-fluoropolymer coated everolimus-eluting stents (FP-EES) have shown lower rates of stent thrombosis (ST) versus bare-metal stents (BMS) and 1st-generation bioabsorbable-polymer (BP) DES. However, the specific role of the FP in thromboresistance has not been explored. METHODS AND RESULTS: A total of 57 stents were assessed in 3 separate ex-vivo swine arterio-venous shunt-model experiments [1st-shunt-experiment, custom-made fluoropolymer-coated BMS (FP-only) vs...
April 3, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29613762/synthetic-nanofiber-reinforced-amniotic-membrane-via-interfacial-bonding
#13
Huanhuan Liu, Zhengbing Zhou, Hui Lin, Juan Wu, Brian Ginn, Ji Suk Choi, Xuesong Jiang, Liam Chung, Jennifer H Elisseeff, Samuel Yiu, Hai-Quan Mao
Severe damage to the ocular surface can result in limbal stem cell (LSC) deficiency, which contributes to loss of corneal clarity, potential vision loss, chronic pain, photophobia, and keratoplasty failure. Human amniotic membrane (AM) is the most effective substrate for LSC transplantation to treat patients with LSC deficiency. However, the widespread use of the AM in the clinic remains a challenge because of the high cost for preserving freshly prepared AM and the weak mechanical strength of lyophilized AM...
April 19, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29578542/a-tailorable-in-situ-light-activated-biodegradable-vascular-scaffold
#14
Mazen S Albaghdadi, Jian Yang, Jessica H Brown, Neel A Mansukhani, Guillermo A Ameer, Melina R Kibbe
Biodegradable vascular scaffolds (BVS) are novel treatments for obstructive atherosclerotic cardiovascular disease that have been developed to overcome the limitations of traditional metallic drug-eluting stents (DES). The mechanical properties of bioabsorbable polymers used for the production of novel BVS are a key consideration for the clinical translation of this emerging technology. Herein, we describe the engineering of an in situ light-activated vascular scaffold (ILVS) comprised of a biodegradable citric acid-based elastomeric polymer, referred to as methacrylated poly-diol citrate (mPDC), and a diazeniumdiolate chitosan nitric oxide donor (chitoNO)...
April 2017: Advanced materials technologies
https://www.readbyqxmd.com/read/29549452/spontaneous-coronary-artery-dissection-diagnosis-and-management
#15
REVIEW
Ilhwan Yeo, Dmitriy N Feldman, Luke K Kim
PURPOSE OF REVIEW: Spontaneous coronary artery dissection (SCAD) is a non-iatrogenic and non-traumatic separation of the coronary arterial wall. While SCAD represents an important cause of myocardial infarction, optimal diagnostic and therapeutic options remain challenging. We sought to review recent studies and provide an update on diagnosis and management of SCAD. RECENT FINDINGS: Coronary angiography is the first-line diagnostic modality for SCAD, with three angiographic features commonly observed in SCAD: type 1 (pathognomonic angiographic appearance with contrast staining of the arterial wall), type 2 (long coronary stenosis), and type 3 (focal tubular stenosis)...
March 17, 2018: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29544509/local-control-of-polymicrobial-infections-via-a-dual-antibiotic-delivery-system
#16
David J Tennent, Stefanie M Shiels, Jessica A Jennings, Warren O Haggard, Joseph C Wenke
BACKGROUND: Contaminated traumatic open orthopedic wounds are frequently complicated by polymicrobial contamination and infection. In high-risk wounds, the standard of care comprises debridement and irrigation combined with antibiotics which can be applied directly or combined with systemic antibiotics. Recently, bioabsorbable chitosan sponges have been shown to be an effective single-agent delivery device for local antibiotics with and without negative pressure wound therapy (NPWT). Severely contaminated orthopedic wounds, however, are often complicated by polymicrobial infections, necessitating multiple antibiotic agents...
March 15, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29530821/zinc-based-alloys-for-degradable-vascular-stent-applications
#17
REVIEW
Ehsan Mostaed, Malgorzata Sikora-Jasinska, Jaroslaw W Drelich, Maurizio Vedani
The search for biodegradable metals with mechanical properties equal or higher to those of currently used permanent biomaterials, such as stainless steels, cobalt chromium and titanium alloys, desirable in vivo degradation rate and uniform corrosion is still an open challenge. Magnesium (Mg), iron (Fe) and zinc (Zn)-based alloys have been proposed as biodegradable metals for medical applications. Over the last two decades, extensive research has been done on Mg and Fe. Fe-based alloys show appropriate mechanical properties, but their degradation rate is an order of magnitude below the benchmark value...
April 15, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29518294/-functional-comparison-in-the-treatment-of-weber-type-b-ankle-fractures-with-suture-device-versus-screw
#18
M M Rius-Zavala, F I Gil-Orbezo, C A Trueba-Davalillo, C Trueba-Vasavilbaso, M Acuña-Tovar
BACKGROUND: Ten percent of all ankle fractures, 20% of the fractures treated surgically, and 1-18% of all sprains involve a syndesmosis injury. The methods used for reduction are metal or bioabsorbable syndesmotic set screws, direct repair, and sutures with or without buttons. The purpose of this study was to compare the clinical function of patients who sustained Weber B ankle fractures and were treated with the TightRope system or a syndesmotic set screw. MATERIAL AND METHODS: An observational, comparative, cross-sectional study was conducted between March 2012 and March 2015...
September 2017: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/29513378/incidence-and-predictors-of-target-lesion-failure-in-a-multiethnic-asian-population-receiving-the-synergy-coronary-stent-a-prospective-all-comers-registry
#19
Rajiv Ananthakrishna, William Kristanto, Li Liu, Siew-Pang Chan, Poay Huan Loh, Edgar L Tay, Koo Hui Chan, Mark Y Chan, Chi-Hang Lee, Adrian F Low, Huay Cheem Tan, Joshua P Loh
OBJECTIVES: To evaluate the target lesion failure (TLF) rate of the SYNERGY stent in all-comers, multiethnic Asian population. BACKGROUND: Currently, most drug eluting stents deliver anti-proliferative drugs from a durable polymer which is associated with a risk of late stent thrombosis. The novel everolimus-eluting, platinum chromium SYNERGY stent is coated with a bioabsorbable abluminal polymer that resolves within 4 months. METHODS: This was a prospective, single center registry of consecutive patients treated with the SYNERGY stent between December 2012 and April 2015...
March 7, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29479686/internal-fixation-of-proximal-fractures-of-the-2nd-and-4th-metacarpal-and-metatarsal-bones-using-bioabsorbable-screws
#20
M Mageed, T Steinberg, N Drumm, N Stubbs, J Wegert, M Koene
OBJECTIVE: Fractures involving the proximal one-third of the splint bone are relatively rare and are challenging to treat. A variety of management techniques have been reported in the literature. The aim of this retrospective case series was to describe the clinical presentation and evaluate the efficacy of bioabsorbable polylactic acid screws in internal fixation of proximal fractures of the 2nd and 4th metacarpal and metatarsal bones in horses. METHODS: The medical records, diagnostic images and outcome of all horses diagnosed with a proximal fracture of the splint bones and treated with partial resection and internal fixation of the proximal stump using bioabsorbable polylactic acid screws between 2014 and 2015 were reviewed...
March 2018: Australian Veterinary Journal
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