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https://www.readbyqxmd.com/read/28923786/final-five-year-clinical-outcomes-in-the-evolve-trial-a-randomized-evaluation-of-a-novel-bioabsorbable-polymer-coated-everolimus-eluting-stent
#1
Ian T Meredith, Stefan Verheye, Christophe Dubois, Joseph Dens, Bruno Farah, Didier Carrié, Simon Walsh, Keith Oldroyd, Olivier Varenne, Seif El-Jack, Raul Moreno, Thomas Christen, Dominic J Allocco
AIMS: Long-term data for bioabsorbable polymer-coated everolimus-eluting stents (BP-EES) are limited. The EVOLVE trial compared the safety and efficacy of 2 dose formulations of SYNERGY BP-EES with permanent polymer-coated PROMUS Element EES (PE). METHODS AND RESULTS: The EVOLVE study was a prospective, multicentre, noninferiority trial that randomised 291 patients with de novo coronary lesions (length: ≤28mm; diameter: ≥2.25 to ≤3.5 mm) to receive PE (n=98), SYNERGY (n=94), or SYNERGY half-dose (n=99)...
September 19, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28918876/evaluation-of-potential-substrates-for-restenosis-and-thrombosis-in-overlapped-versus-edge-to-edge-juxtaposed-bioabsorbable-scaffolds-insights-from-a-computed-fluid-dynamic-study
#2
Gianluca Rigatelli, Marco Zuin, Fabio Dell'Avvocata, Paolo Cardaioli, Dobrin Vassiliev, Miroslaw Ferenc, Nguyen Tuan Nghia, Thach Nguyen, Nicholas Foin
BACKGROUND/PURPOSE: Multiple BRSs and specifically the Absorb scaffold (BVS) (Abbott Vascular, Santa Clara, CA USA) have been often used to treat long diffuse coronary artery lesions. We evaluate by a computational fluid dynamic(CFD) study the impact on the intravascular fluid rheology on multiple bioabsorbable scaffolds (BRS) by standard overlapping versus edge-to-edge technique. METHODS/MATERIALS: We simulated the treatment of a real long significant coronary lesion (>70% luminal narrowing) involving the left anterior descending artery (LAD) treated with a standard or edge-to-edge technique, respectively...
August 17, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28917119/a-mechanistic-model-for-drug-release-from-plga-based-drug-eluting-stent-a-computational-study
#3
Jahed Naghipoor, Timon Rabczuk
Atherosclerosis in the coronary artery is one of the leading causes of death in the world. The stenting as a minimally invasive technique was considered as an effective tool to reduce the severity of atherosclerotic stenosis. In-stent restenosis is the main drawback of the stenting in the coronary artery. Understanding the mechanism of drug release from drug-eluting stents and drug uptake in the arterial wall and obtaining more information about their functionality using mathematical modeling and numerical simulation, could be considered as a predictive tool to investigate in-stent restenosis growth which is experimentally expensive to study...
September 8, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28915914/paradoxical-tunnel-enlargement-after-acl-reconstruction-with-hamstring-autografts-when-using-%C3%AE-tcp-containing-interference-screws-for-tibial-aperture-fixation-prospectively-comparative-study
#4
Joon Ho Wang, Eun Su Lee, Byung Hoon Lee
BACKGROUND: Tibial aperture fixation with a bioabsorbable interference screw is a popular fixation method in anterior cruciate ligament reconstruction (ACLR). An interference screw containing β-tricalcium phosphate (β-TCP) to improve bony integration and biocompatibility was recently introduced. This study aims to compare the clinical outcomes and radiological results of tunnel enlargement effect between the 2 bioabsorbable fixative devices of pure poly-L-lactic acid (PLLA) interference screws and β-TCP-containing screws, for tibial interference fixation in ACLR using hamstring autografts...
September 16, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28893770/serial-5-year-evaluation-of-side-branches-jailed-by-bioresorbable-vascular-scaffolds-using-3-dimensional-optical-coherence-tomography-insights-from-the-absorb-cohort-b-trial-a-clinical-evaluation-of-the-bioabsorbable-everolimus-eluting-coronary-stent-system
#5
Yoshinobu Onuma, Maik J Grundeken, Shimpei Nakatani, Taku Asano, Yohei Sotomi, Nicolas Foin, Jaryl Ng, Takayuki Okamura, Joanna J Wykrzykowska, Robbert J de Winter, Robert-Jan van Geuns, Jacques Koolen, Evald Christiansen, Robert Whitbourn, Dougal McClean, Pieter Smits, Stephan Windecker, John A Ormiston, Patrick W Serruys
BACKGROUND: The long-term fate of Absorb bioresorbable vascular scaffold (Abbott Vascular, Santa Clara, CA) struts jailing side branch ostia has not been clarified. We therefore evaluate serially (post-procedure and at 6 months, 1, 2, 3, and 5 years) the appearance and fate of jailed Absorb bioresorbable vascular scaffold struts. METHODS AND RESULTS: We performed 3-dimensional optical coherence tomographic analysis of the ABSORB Cohort B trial (A Clinical Evaluation of the Bioabsorbable Everolimus Eluting Coronary Stent System in the Treatment of Patients With De Novo Native Coronary Artery Lesions) up to 5 years using a novel, validated cut-plane analysis method...
September 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28888079/bioabsorbable-nerve-conduits-coated-with-induced-pluripotent-stem-cell-derived-neurospheres-enhance-axonal-regeneration-in-sciatic-nerve-defects-in-aged-mice
#6
Takuya Yokoi, Takuya Uemura, Kiyohito Takamatsu, Kosuke Shintani, Ema Onode, Mitsuhiro Okada, Noriaki Hidaka, Hiroaki Nakamura
Aging influences peripheral nerve regeneration. Nevertheless, most basic research of bioabsorbable nerve conduits including commercial products have been performed in very young animals. Results from these studies may not provide information about axonal regeneration in aged tissue, because young nerve tissue holds sufficient endogenous potential for axonal regeneration. The clinical target age for nerve conduit application is most likely going to increase with a rapidly growing elderly population. In the present study, we examined axonal regeneration after sciatic nerve defects in aged and young mice...
September 9, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28866342/recurrent-instability-after-arthroscopic-bankart-reconstruction-a-systematic-review-of-surgical-technical-factors
#7
REVIEW
Landon Brown, Shane Rothermel, Rajat Joshi, Aman Dhawan
PURPOSE: Recurrent instability remains of concern after arthroscopic Bankart reconstruction. We evaluated various technical factors including anchor design, anchor material, number of anchors used, and interval closure on risk of recurrent instability after arthroscopic Bankart reconstruction. METHODS: A systematic review of MEDLINE and Cochrane databases was conducted, following PRISMA guidelines. Extracted data were recorded on a standardized form. Methodological index for non-randomized studies (MINORS) and Newcastle-Ottawa Scale (NOS) were used to assess study quality and risk bias...
August 30, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28866034/bioabsorbable-stents-a-solution-in-search-of-a-problem
#8
EDITORIAL
Frederick G P Welt
No abstract text is available yet for this article.
August 24, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28861193/comparison-of-poly-l-lactic-acid-and-poly-l-lactic-acid-hydroxyapatite-bioabsorbable-screws-for-tibial-fixation-in-acl-reconstruction-clinical-and-magnetic-resonance-imaging-results
#9
Dhong Won Lee, Ji Whan Lee, Sang Bum Kim, Jung Ho Park, Kyu Sung Chung, Jeong Ku Ha, Jin Goo Kim, Woo Jong Kim
BACKGROUND: The purpose of this study was to compare the clinical and radiological results of 2 different tibial fixations performed using bioabsorbable screws with added hydroxyapatite (HA) and pure poly-L-lactic acid (PLLA) screws in anterior cruciate ligament (ACL) reconstruction. METHODS: A total of 394 patients who underwent arthroscopic ACL reconstruction between March 2009 and June 2012 were retrospectively reviewed. Of those, 172 patients who took the radiological and clinical evaluations at more than 2 years after surgery were enrolled and divided into 2 groups: PLLA group (n = 86) and PLLA-HA group (n = 86)...
September 2017: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/28857777/barbed-ribbon-device-for-progressive-tension-closure-reduces-seroma-after-breast-reconstruction
#10
Devan Griner, Caleb M Steffen, Kristopher M Day, Mark A Brzezienski
PURPOSE: Implant-based breast reconstruction is fraught with complications related to seroma formation. Soft tissue stabilization with progressive tension closure (PTC) has been shown to decrease seroma formation after various procedures but is less suitable for mastectomy flap stabilization. We evaluate the incidence of seroma in breast reconstruction using bioabsorbable barbed ribbon devices (BRDs) as a novel approach to PTC. METHODS: We performed a retrospective review of all patients whose mastectomy flaps were stabilized with BRDs...
August 29, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28838256/comparative-study-of-different-polymeric-coatings-for-the-next-generation-magnesium-based-biodegradable-stents
#11
Gholamreza Ahmadi Lakalayeh, Mostafa Rahvar, Esmaeil Haririan, Roya Karimi, Hossein Ghanbari
Development of next-generation bioabsorbable stents based on magnesium alloys is gaining lots of attention. However, finding an appropriate coating in order to enhance its corrosion resistance along with preserving other requirements is still a challenge. In this study, three FDA-approved polymers, namely poly(lactic acid), polycaprolactone and poly(lactic-co-glycolic acid), have been investigated as potential coatings for magnesium-based stents to enhance their corrosion resistance, biocompatibility and haemocompatibility...
August 24, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28829747/mid-term-performance-of-a-novel-restorative-pulmonary-valved-conduit-preclinical-results
#12
Osama I I Soliman, Yosuke Miyazaki, Mohammad Abdelghani, Marieke Brugmans, Maarten Witsenburg, Yoshinobu Onuma, Martijn Cox, Patrick W Serruys
AIMS: A bioabsorbable pulmonary valved-conduit (XPV), designed to guide functional restoration patients own tissue, is potentially more durable than current pulmonary bioprosthetic valves/valved-conduits. The aim of this study was to assess the hemodynamic performance of the novel XPV implanted in an ovine model. METHODS AND RESULTS: The XPV was surgically implanted in adult sheep under general anaesthesia and cardiopulmonary bypass (XPV-group, n=20). Sheep that received a Hancock bioprosthetic pulmonary valved-conduit served as a control group (HPV-group, n=3)...
August 22, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28812035/bioabsorbable-versus-metal-screw-in-the-fixation-of-tibial-tubercle-transfer-a-cadaveric-biomechanical-study
#13
Janne T Nurmi, Ari Itälä, Raine Sihvonen, Petri Sillanpää, Pekka Kannus, Harri Sievänen, Teppo L N Järvinen
BACKGROUND: In tibial tubercle transfer (TTT) procedures, the osteotomized and transferred tibial tubercle is usually fixed into the host bone using metal screws. PURPOSE: To compare the strength of fixation provided by a single bioabsorbable screw versus a metal screw for TTT. STUDY DESIGN: Controlled laboratory study. METHODS: Twenty-two pairs of human cadaveric tibiae were used to compare the fixation strength of a single 4...
July 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28801538/comparison-of-acute-thrombogenicity-for-metallic-and-polymeric-bioabsorbable-scaffolds-magmaris-versus-absorb-in-a-porcine-arteriovenous-shunt-model
#14
Ron Waksman, Michael J Lipinski, Eduardo Acampado, Qi Cheng, Lila Adams, Sho Torii, Jiaxiang Gai, Rebecca Torguson, David M Hellinga, Peter C Westman, Michael Joner, Philine Zumstein, Frank D Kolodgie, Renu Virmani
BACKGROUND: A comparison in acute thrombogenicity between the Magmaris sirolimus-eluting bioabsorbable magnesium scaffold and the Absorb bioresorbable vascular scaffold has not been performed. This study assessed acute thrombogenicity of Magmaris compared with Absorb and the Orsiro hybrid drug-eluting stent in a porcine arteriovenous shunt model. METHODS AND RESULTS: An ex vivo porcine carotid jugular arteriovenous shunt was established and connected to SYLGARD tubing containing the Magmaris, Absorb, and Orsiro scaffolds/stents and allowed to run in the shunt for a maximum of 1 hour...
August 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28780703/radiolucent-rings-around-bioabsorbable-anchors-after-rotator-cuff-repair-are-not-associated-with-clinical-outcomes
#15
Jin-Young Park, Suk-Hwan Jang, Kyung-Soo Oh, Yi Jin Li
PURPOSE: Various researchers have observed small areas of osteolysis after using bioabsorbable anchors in shoulder surgeries. The purpose of this study is to determine whether radiographic perianchor radiolucent rings after rotator cuff repair are associated with the failure of repair and also assess their clinical implications. Further, the most frequent location of the radiolucent rings in the double-row suture bridge configuration was also assessed. METHODS: One hundred and twenty-nine consecutive patients who underwent arthroscopic rotator cuff repair by suture bridge technique were retrospectively evaluated radiographically and clinically...
August 5, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28773109/thermomechanical-properties-of-polylactic-acid-graphene-composites-a-state-of-the-art-review-for-biomedical-applications
#16
REVIEW
Ilker S Bayer
Due to its biodegradable and bioabsorbable characteristics polylactic acid (PLA) has attracted considerable attention for numerous biomedical applications. Moreover, a number of tissue engineering problems for function restoration of impaired tissues have been addressed by using PLA and its copolymers due to their biocompatibility and distinctive mechanical properties. Recent studies on various stereocomplex formation between enantiomeric PLA, poly(l-lactide) (PLLA) and poly(d-lactide) (PDLA) indicated that stereocomplexation enhances the mechanical properties as well as the thermal- and hydrolysis-resistance of PLA polymers...
July 4, 2017: Materials
https://www.readbyqxmd.com/read/28741576/a-randomized-comparison-of-biodegradable-polymer-and-permanent-polymer-coated-platinum-chromium-everolimus-elutingcoronary-stents-in-china-the-evolve-china-study
#17
YaLing Han, Haiwei Liu, Yuejin Yang, Jian Zhang, Kai Xu, Guosheng Fu, Xi Su, Tiemin Jiang, Wenyue Pang, Jiyan Chen, Zuyi Yuan, Hui Li, Haichang Wang, Tao Hong, Huiliang Liu, Fucheng Sun, Dominic J Allocco, Mingdong Zhang, Keith D Dawkins
AIMS: The EVOLVE China randomized study sought to evaluate clinical safety and effectiveness of the SYNERGY bioabsorbable polymer-coated everolimus-eluting stent (EES) for the treatment of patients with coronary heart disease in China. METHODS AND RESULTS: Eligible patients with de novo native coronary artery lesions were randomized (1:1) to receive the SYNERGY or PROMUS Element Plus (PE Plus) stents. The primary endpoint was in-stent late loss at 9 months. Secondary endpoints included death, MI, revascularization, and stent thrombosis through 12 months...
July 25, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28731889/stent-thrombosis-with-bioabsorbable-polymer-drug-eluting-stents-insights-from-the-food-and-drug-administration-database
#18
Abdur R Khan, Avnish Tripathi, Talha A Farid, Bilal Abaid, Deepak L Bhatt, Jon R Resar, Michael P Flaherty
BACKGROUND: SYNERGY, a bioabsorbable polymer-based, everolimus-eluting stent (BP-DES), recently received regulatory approval in the USA for use in percutaneous coronary interventions. Yet, information on the safety of BP-DES in routine clinical practice is limited. Our aim was to compare the safety of the recently approved BP-DES with current durable polymer drug-eluting stents (DP-DES) by analyzing adverse events, namely, stent thrombosis (ST), reported to the Manufacturer and User Facility Device Experience (MAUDE) database...
July 20, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28717988/bioabsorbable-implants-for-subtalar-arthroereisis-in-pediatric-flatfoot
#19
REVIEW
C Faldini, A Mazzotti, A Panciera, F Perna, N Stefanini, S Giannini
Flatfoot is a common condition in growing-age patients. Despite its common presentation, nowadays surgical indications and treatments are still debated. Arthroereisis is a widely used technique, and several implants designs have been proposed over time. Despite the good results shown in the literature, the main drawback of these techniques has always been the need for a second surgery for implant removal. Bioabsorbable devices have been introduced to overcome this necessity.Correct approach to the patient, indications and contraindications and available studies on bioabsorbable implants for subtalar arthroereisis in pediatric flatfoot were analyzed in this narrative review...
July 17, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/28709792/fixation-of-ultrasmall-proximal-pole-scaphoid-fractures-using-bioabsorbable-osteochondral-fixation-nails
#20
REVIEW
Eugene T Ek, Kemble Wang
Surgical treatment of ultrasmall proximal pole scaphoid fractures poses a number of challenges. The fragment may be too small to fix with conventional headless screw fixation owing to the high risk of fragmentation upon insertion. However, excision of the fragment risks compromising the scapholunate ligament complex and also exposes the radioscaphoid joint to potential degenerative changes. Under these circumstances, we describe the use of bioabsorbable osteochondral fixation nails that allows stable low-profile fixation while minimizing the risk of fracturing the proximal pole...
September 2017: Journal of Hand Surgery
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