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https://www.readbyqxmd.com/read/28822854/involvement-of-cyclic-nucleotide-gated-channels-in-spontaneous-activity-generated-in-isolated-interstitial-cells-of-cajal-from-the-rabbit-urethra
#1
Maria Sancho, Eamonn Bradley, Angeles Garcia-Pascual, Domingo Triguero, Keith D Thornbury, Mark A Hollywood, Gerard P Sergeant
Cyclic nucleotide-gated (CNG) channels are non-selective cation channels that mediate influx of extracellular Na(+) and Ca(2+) in various cell types. L-cis-Diltiazem, a CNG channel blocker, inhibits contraction of urethral smooth muscle (USM), however the mechanisms underlying this effect are still unclear. We investigated the possibility that CNG channels contribute to spontaneous pacemaker activity in freshly isolated interstitial cells of Cajal (ICC) isolated from the rabbit urethra (RUICC). Using immunocytochemistry, we found intense CNG1-immunoreactivity in vimentin-immunoreactive RUICC, mainly within patches of the cellular body and processes...
August 16, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28822805/mg53-is-dispensable-for-t-tubule-maturation-but-critical-for-maintaining-t-tubule-integrity-following-cardiac-stress
#2
Caimei Zhang, Biyi Chen, Yihui Wang, Ang Guo, Yiqun Tang, Tahsin Khataei, Yun Shi, William J Kutschke, Kathy Zimmerman, Robert M Weiss, Jie Liu, Christopher J Benson, Jiang Hong, Jianjie Ma, Long-Sheng Song
The cardiac transverse (T)-tubule membrane system is the safeguard for cardiac function and undergoes dramatic remodeling in response to cardiac stress. However, the mechanism by which cardiomyocytes repair damaged T-tubule network remains unclear. In the present study, we tested the hypothesis that MG53, a muscle-specific membrane repair protein, antagonizes T-tubule damage to protect against maladaptive remodeling and thereby loss of excitation-contraction coupling and cardiac function. Using MG53-knockout (MG53-KO) mice, we first established that deficiency of MG53 had no impact on maturation of the T-tubule network in developing hearts...
August 16, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28822763/activating-transcription-factor-3-regulates-chemokine-expression-in-contracting-c2c12-myotubes-and-in-mouse-skeletal-muscle-after-eccentric-exercise
#3
R Fernández-Verdejo, A M Vanwynsberghe, T Hai, L Deldicque, M Francaux
Activating transcription factor (ATF) 3 regulates chemokine expression in various cell types and tissues. Herein, we studied this regulation in contracting muscle cells in vitro, and in skeletal muscle after muscle-damaging exercise in vivo. C2C12 myotubes with normal or low ATF3 levels (atf3_siRNA) were electrically stimulated (EPS). Also, ATF3-knockout (ATF3-KO) and control mice ran downhill until exhaustion, and muscles were analyzed post-exercise. EPS increased ATF3 levels in myotubes (P < 0.01). Chemokine C-C motif ligand (ccl) 2 mRNA increased post-EPS, but atf3_siRNA attenuated the response (P < 0...
August 16, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28821950/the-effects-of-supramaximal-versus-submaximal-intensity-eccentric-training-when-performed-until-volitional-fatigue
#4
Joel R Krentz, Philip D Chilibeck, Jonathan P Farthing
PURPOSE: Our purpose was to compare supramaximal versus submaximal intensity eccentric training performed until volitional fatigue. METHODS: Thirty-two young adults (19 males) were randomized into one of three groups: (1) ECC110 performed eccentric (ECC) only contractions at 110% of concentric (CON) 1-repetition maximum (1RM); (2) ECC80 performed ECC only contractions at 80% of CON 1RM; (3) a control group. Training progressed from 3 to 6 sets of unilateral ECC training of the elbow flexors over 8 weeks, with each set performed until volitional fatigue...
August 18, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28821927/control-of-wrist-movement-in-deafferented-man-evidence-for-a-mixed-strategy-of-position-and-amplitude-control
#5
R Chris Miall, P Haggard, J D Cole
There is a continuing debate about control of voluntary movement, with conflicted evidence about the balance between control of movement vectors (amplitude control) that implies knowledge of the starting position for accuracy, and equilibrium point or final position control, that is independent of the starting conditions. We tested wrist flexion and extension movements in a man with a chronic peripheral neuronopathy that deprived him of proprioceptive knowledge of his wrist angles. In a series of experiments, we demonstrate that he could scale the amplitude of his wrist movements in flexion/extension, even without visual feedback, and appeared to adopt a strategy of moving via a central wrist position when asked to reach target angles from unknown start locations...
August 18, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28821716/transcriptome-analysis-reveals-long-intergenic-non-coding-rnas-involved-in-skeletal-muscle-growth-and-development-in-pig
#6
Cheng Zou, Jingxuan Li, Wenzhe Luo, Long Li, An Hu, Yuhua Fu, Ye Hou, Changchun Li
Long intergenic non-coding RNAs (lincRNAs) play essential roles in numerous biological processes and are widely studied. The skeletal muscle is an important tissue that plays an essential role in individual movement ability. However, lincRNAs in pig skeletal muscles are largely undiscovered and their biological functions remain elusive. In this study, we assembled transcriptomes using RNA-seq data published in previous studies of our laboratory group and identified 323 lincRNAs in porcine leg muscle. We found that these lincRNAs have shorter transcript length, fewer exons and lower expression level than protein-coding genes...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821650/feedback-signal-from-motoneurons-influences-a-rhythmic-pattern-generator
#7
Horacio G Rotstein, Elisa Schneider, Lidia Szczupak
Motoneurons are not mere output units of neuronal circuits that control motor behavior, but participate in pattern generation. Research on the circuit that controls the crawling motor behavior in leeches indicated that motoneurons participate as modulators of this rhythmic motor pattern. Crawling results from successive bouts of elongation and contraction of the whole leech body. In the isolated segmental ganglia dopamine can induce a rhythmic antiphasic activity of the motoneurons that control contraction (DE-3 motoneurons) and elongation (CV motoneurons)...
August 16, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28820947/dysregulated-mitogen-activated-protein-kinase-and-matrix-metalloproteinase-in-ethanol-induced-cavernosal-dysfunction
#8
Jaqueline Jóice Muniz, Leticia Nogueira Leite, Riccardo Lacchini, Jose E Tanus-Santos, Carlos Renato Tirapelli
We evaluated the effects of ethanol consumption on the mitogen-activated protein kinases (MAPK) and metalloproteinases (MMP) pathways in the rat cavernosal smooth muscle (CSM). Male Wistar rats were treated with ethanol (20% vol./vol.) for six weeks. Quantitative real-time polymerase chain reaction experiments showed that ethanol consumption did not alter mRNA levels of p38MAPK, SAPK/JNK, ERK1/2, MMP-2 or MMP-9 in the rat CSM. Western immunoblotting experiments revealed decreased protein expression of p38MAPK and phosphorylation of SAPK/JNK in the CSM from ethanol-treated rats...
August 18, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28820846/noninvasive-assessment-of-skeletal-muscle-myosin-heavy-chain-expression-in-trained-and-untrained-men
#9
Andrew C Fry, Terry J Housh, Joel B Cramer, Joseph P Weir, Travis W Beck, Brian K Schilling, Jonathan D Miller, Justin X Nicoll
Fry, AC, Housh, TJ, Cramer, JB, Weir, JP, Beck, TW, Schilling, BK, Miller, JD, and Nicoll, JX. Noninvasive assessment of skeletal muscle myosin heavy chain expression in trained and untrained men. J Strength Cond Res 31(9): 2355-2362, 2017-Numerous conditions and types of physical activity (e.g., exercise, aging, and muscle-related diseases) can influence muscle fiber types and the proteins expressed. To date, muscle fibers can only be characterized by actually obtaining a tissue sample using the invasive muscle biopsy procedure...
September 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28820400/alteration-in-expressions-of-rhoa-and-rho-kinases-during-pregnancy-in-rats-their-roles-in-uterine-contractions-and-onset-of-labour
#10
D Domokos, E Ducza, G Falkay, R Gaspar
Activation of RhoA and Rho-associated kinases (ROCKs) is known to play a pivotal role in the regulation of smooth muscle contraction via phosphorylation of myosin-light chain and myosin phosphatase. There are few data on the RhoA and ROCKs expression levels in rat uteri. Therefore, our aim was to investigate the mRNA and protein concentration of RhoA and ROCKs in rat uterus during pregnancy, during parturition and post-partum using real time PCR and Western blot analysis. The other purpose was to evaluate the effects of the ROCK (Y-27632, fasudil and RKI 1441) and RhoA inhibitors (simvastatin) on uterine contractility in isolated organ bath experiments...
June 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28820399/repetitive-muscle-compression-reduces-vascular-mechano-sensitivity-and-the-hyperemic-response-to-muscle-contraction
#11
A Messere, M Turturici, G Millo, S Roatta
Animal studies have shown that the rapid hyperemic response to external muscle compression undergoes inactivation upon repetitive stimulation, but this phenomenon has never been observed in humans. The aim of the present study was to determine whether 1) the vascular mechano-sensitivity underlying muscle compression-induced hyperemia is inactivated in an inter-stimulus interval (ISI)-dependent fashion upon repetitive stimulation, as suggested by animal studies, and 2) whether such inactivation also attenuates contraction-induced hyperemia...
June 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28819679/neuromuscular-electrical-stimulation-is-effective-in-strengthening-the-quadriceps-muscle-after-anterior-cruciate-ligament-surgery
#12
REVIEW
Annette V Hauger, M P Reiman, J M Bjordal, C Sheets, L Ledbetter, A P Goode
PURPOSE: Reduced ability to contract the quadriceps muscles is often found immediately following anterior cruciate ligament (ACL) surgery. This can lead to muscle atrophy and decreased function. Application of neuromuscular electrical stimulation (NMES) may be a useful adjunct intervention to ameliorate these deficits following ACL surgery. The purpose of this review was to determine whether NMES in addition to standard physical therapy is superior to standard physical therapy alone in improving quadriceps strength or physical function following ACL surgery...
August 17, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28819051/the-effects-of-8-weeks-voluntary-wheel-running-on-the-contractile-performance-of-isolated-locomotory-soleus-and-respiratory-diaphragm-skeletal-muscle-during-early-ageing
#13
Jason Tallis, Matthew F Higgins, Frank Seebacher, Val M Cox, Michael J Duncan, Rob S James
Decreased skeletal muscle performance with increasing age is strongly associated with reduced mobility and quality of life. Increased physical activity is a widely prescribed method of reducing the detrimental effects of ageing on skeletal muscle contractility. The present study uses isometric and work loop testing protocols to uniquely investigate the effects of 8 weeks of voluntary wheel running on the contractile performance of isolated dynapenic soleus and diaphragm muscles of 38 week old CD1 mice. When compared to untrained controls, voluntary wheel running induced significant improvements in maximal isometric stress and work loop power, a reduced resistance to fatigue, but greater cumulative work during fatiguing work loop contractions in isolated muscle...
August 17, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28818208/catecholamine-dependent-%C3%AE-adrenergic-signaling-in-a-pluripotent-stem-cell-model%C3%A2-of-takotsubo-cardiomyopathy
#14
Thomas Borchert, Daniela Hübscher, Celina I Guessoum, Tuan-Dinh D Lam, Jelena R Ghadri, Isabel N Schellinger, Malte Tiburcy, Norman Y Liaw, Yun Li, Jan Haas, Samuel Sossalla, Mia A Huber, Lukas Cyganek, Claudius Jacobshagen, Ralf Dressel, Uwe Raaz, Viacheslav O Nikolaev, Kaomei Guan, Holger Thiele, Benjamin Meder, Bernd Wollnik, Wolfram-Hubertus Zimmermann, Thomas F Lüscher, Gerd Hasenfuss, Christian Templin, Katrin Streckfuss-Bömeke
BACKGROUND: Takotsubo syndrome (TTS) is characterized by an acute left ventricular dysfunction and is associated with life-threating complications in the acute phase. The underlying disease mechanism in TTS is still unknown. A genetic basis has been suggested to be involved in the pathogenesis. OBJECTIVES: The aims of the study were to establish an in vitro induced pluripotent stem cell (iPSC) model of TTS, to test the hypothesis of altered β-adrenergic signaling in TTS iPSC-cardiomyocytes (CMs), and to explore whether genetic susceptibility underlies the pathophysiology of TTS...
August 22, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28817976/an-open-source-model-and-solution-method-to-predict-co-contraction-in-the-finger
#15
Alexander R MacIntosh, Peter J Keir
A novel open-source biomechanical model of the index finger with an electromyography (EMG)-constrained static optimization solution method are developed with the goal of improving co-contraction estimates and providing means to assess tendon tension distribution through the finger. The Intrinsic model has four degrees of freedom and seven muscles (with a 14 component extensor mechanism). A novel plugin developed for the OpenSim modelling software applied the EMG-constrained static optimization solution method...
August 17, 2017: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/28817961/evaluating-the-ergonomics-of-flexible-ureteroscopy
#16
Wesley Ludwig, Gyusung I Lee, Justin Bradley Ziemba, Joan S Ko, Brian Matlaga
INTRODUCTION: To date, the ergonomics of flexible ureteroscopy (URS) have not been well described. We performed a study to assess the biomechanical stresses on urologists performing URS and to investigate the effect of ureteroscope type on these parameters. METHODS: Electromyography (EMG) was used to quantify the activation level of muscle groups involved in URS. Surface EMG electrodes (Delsys, Boston, MA) were placed on the right and left thenar, flexor carpi ulnaris (FCU), extensor carpi ulnaris (ECU), biceps, triceps and deltoid...
August 17, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28817840/nuciferine-relaxes-tracheal-rings-via-the-blockade-of-vdlcc-and-nscc-channels
#17
Xiao Yang, Meng-Fei Yu, Jun Lei, Yong-Bo Peng, Ping Zhao, Lu Xue, Weiwei Chen, Li-Qun Ma, Qing-Hua Liu, Jinhua Shen
This study aimed to elucidate the mechanisms of nuciferine (a main aporphine alkaloid of lotus leaf extract), which can induce relaxation in contracted tracheal rings. Under Ca(2+)-free and 2 mM Ca(2+) conditions, we found that nuciferine had no effect on the resting muscle tone of tracheal rings. In contrast, nuciferine relaxed high K(+)-contracted mouse tracheal rings in a dose-dependent manner and inhibited both Ca(2+) influx and voltage-dependent L-type Ca(2+) channel currents induced by high K(+). Similarly, nuciferine also inhibited acetylcholine-induced contractions in mouse tracheal rings in a dose-dependent manner...
August 17, 2017: Planta Medica
https://www.readbyqxmd.com/read/28815524/endoplasmic-reticulum-plasma-membrane-contacts-regulate-cellular-excitability
#18
Eamonn J Dickson
Cells that have intrinsic electrical excitability utilize changes in membrane potential to communicate with neighboring cells and initiate cellular cascades. Excitable cells like neurons and myocytes have evolved highly specialized subcellular architectures to translate these electrical signals into cellular events. One such structural specialization is sarco-/endoplasmic reticulum-plasma membrane contact sites. These membrane contact sites are positioned by specific membrane-membrane tethering proteins and contain an ever-expanding list of additional proteins that organize information transfer across the junctional space (~ 15-25 nm distance) to shape membrane identity and control cellular excitability...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28814849/tiotropium-bromide-exerts-anti-inflammatory-effects-during-resistive-breathing-an-experimental-model-of-severe-airway-obstruction
#19
Dimitrios Toumpanakis, Konstantinos Loverdos, Vassiliki Tzouda, Vyronia Vassilakopoulou, Eleni Litsiou, Christina Magkou, Vassiliki Karavana, Michael Pieper, Theodoros Vassilakopoulos
INTRODUCTION: Resistive breathing (RB), a hallmark of obstructive airway diseases, is characterized by strenuous contractions of the inspiratory muscles that impose increased mechanical stress on the lung. RB is shown to induce pulmonary inflammation in previous healthy animals. Tiotropium bromide, an anticholinergic bronchodilator, is also shown to exert anti-inflammatory effects. The effect of tiotropium on RB-induced pulmonary inflammation is unknown. METHODS: Adult rats were anesthetized, tracheostomized and breathed spontaneously through a two-way non-rebreathing valve...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28814028/quantitative-assessment-of-swallowing-activity-by-mmg-measurement-with-pvdf-film
#20
Hashimoto Takuya, Tsukagoshi Keita, Koike Takuji
Difficulty of swallowing, called dysphagia, leads to aspiration pneumonia which is particularly a big health concern in aging societies. Therefore, prevention and treatment of dysphagia would contribute to extending healthy-life and QOL of elderly people and decreasing healthcare cost. Robotics technologies are expected as one of the effective methods to solve the problem in terms of detecting malfunction in swallowing and recovering swallowing function. The aim of this study is to investigate muscle activity during normal swallowing using mechanomyography (MMG) with PolyVinylidene DiFluoride (PVDF) film which is a ferroelectrics polymer...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
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