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https://www.readbyqxmd.com/read/29026886/clinical-characteristics-of-acute-drug-induced-dystonia-in-pediatric-patients
#1
Hyun Woong Park, Jae Ryung Kwak, Ji Sook Lee
OBJECTIVE: Dystonia is a movement disorder in which muscles contract uncontrollably. Acute drug-induced dystonia (DID) can be diagnosed through detailed history taking and physical examination. This study aimed to identify the clinical characteristics of DID in children, which could help emergency physicians diagnose these conditions more efficiently. METHODS: We reviewed medical records of children aged below 18 years diagnosed with drug-related dystonia after discharge from the emergency department over 10 years...
September 2017: Clinical and Experimental Emergency Medicine
https://www.readbyqxmd.com/read/29026661/tenth-case-of-bilateral-hemifacial-spasm-treated-by-microvascular-decompression-review-of-the-pathophysiology
#2
REVIEW
Warley Carvalho da Silva Martins, Lucas Alverne Freitas de Albuquerque, Gervásio Teles Cardoso de Carvalho, Jules Carlos Dourado, Marcos Dellaretti, Atos Alves de Sousa
BACKGROUND: Bilateral hemifacial spasm (BHFS) is a rare neurological syndrome whose diagnosis depends on excluding other facial dyskinesias. We present a case of BHFS along with a literature review. METHODS: A 64-year-old white, hypertense male reported involuntary left hemiface contractions in 2001 (aged 50). In 2007, right hemifacial symptoms appeared, without spasm remission during sleep. Botulinum toxin type A application produced partial temporary improvement...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29026428/evaluation-of-the-physiological-activity-of-venom-from-the-eurasian-water-shrew-neomys-fodiens
#3
Krzysztof Kowalski, Paweł Marciniak, Grzegorz Rosiński, Leszek Rychlik
BACKGROUND: Animal toxins can have medical and therapeutic applications. Principally, toxins produced by insects, arachnids, snakes and frogs have been characterized. Venomous mammals are rare, and their venoms have not been comprehensively investigated. Among shrews, only the venom of Blarina brevicauda has been analysed so far, and blarina toxin has been proven to be its main toxic component. It is assumed that Neomys fodiens employs its venom to hunt larger prey. However, the toxic profile, properties and mode of action of its venom are largely unknown...
2017: Frontiers in Zoology
https://www.readbyqxmd.com/read/29024827/left-ventricular-non-compaction-with-ebstein-anomaly-attributed-to-a-tpm1-mutation
#4
Aleksandra Nijak, Maaike Alaerts, Cuno Kuiperi, Anniek Corveleyn, Bert Suys, Bernard Paelinck, Johan Saenen, Emeline Van Craenenbroeck, Lut Van Laer, Bart Loeys, Aline Verstraeten
Left ventricular non-compaction (cardiomyopathy) (LVN(C)) is a rare hereditary cardiac condition, resulting from abnormal embryonic myocardial development. While it mostly occurs as an isolated condition, association with other cardiovascular manifestations such as Ebstein anomaly (EA) has been reported. This congenital heart defect is characterized by downward displacement of the tricuspid valve and leads to diminished ventricular size and function. In an autosomal dominant LVN(C) family consisting of five affected individuals, of which two also presented with EA and two others with mitral valve insufficiency, we pursued the genetic disease cause using whole exome sequencing (WES)...
October 9, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29024706/identification-of-circular-rnas-in-human-aortic-valves
#5
Jianle Chen, Jun Wang, Yun Jiang, Weidong Gu, Buqing Ni, Haoliang Sun, Wanjun Gu, Liang Chen, Yongfeng Shao
With the wide application of RNA-Seq technology, thousands of circular RNAs (circRNAs) have been identified in different type of tissues and cells in many organisms, but little is known on the human aortic valve expressed circRNAs. In this study, we identified all circRNAs in two calcified human aortic valves, and characterized the features of all circRNAs. A total of 5476 circRNAs were identified in human aortic valves, including 1412 (25.79%) aortic valve specific circRNAs. Next, we showed that most aortic valve specific circRNAs were derived from the exonic regions of their host genes, and majority of the host genes contained less than three circRNAs...
October 9, 2017: Gene
https://www.readbyqxmd.com/read/29024603/exercise-tolerance-during-muscle-contractions-below-and-above-the-critical-torque-in-different-muscle-groups
#6
Leonardo Henrique Perinotto Abdalla, Benedito Sérgio Denadai, Natalia Menezes Bassan, Camila Coelho Greco
The objective of this study was to test the hypotheses that end-test torque (ET) (expressed as % maximal voluntary contraction - MVC) is higher for plantar flexors (PF) than knee extensors (KE) muscles, whereas impulse above ET (IET) is higher for KE than PF. Thus, we expected that exercise tolerance would be longer for KE than PF only during the exercise performed above ET. After the determination of MVC, forty men performed two 5-min all-out tests to determine ET and IET. Eleven participants performed a further four intermittent isometric tests, to exhaustion, at ET + 5% and ET - 5%, and one test for KE at the exercise intensity (%MVC) corresponding to ET + 5% of PF...
October 12, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29024213/the-newborn-rat-gastric-emptying-rate-is-volume-and-not-developmentally-dependent
#7
C H F Ferreira, Y Shifrin, J Pan, J Ivanovska, P J McNamara, J Belik
BACKGROUND: Gastric residuals are a common finding in enterally fed preterm neonates and traditionally thought to reflect immaturity-related delayed gastric emptying. Adult human data suggest that the meal volume regulate the gastric emptying rate, but early in life, this has not been adequately evaluated. The goal of this study was to study the rat postnatal changes in gastric emptying rate and the strain-induced effect on muscle contraction. We hypothesized that the stomach content volume and not developmental factors determines the newborn gastric emptying rate, via the Rho-kinase 2 (ROCK-2) pathway...
October 11, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29024196/pelvic-floor-muscle-assessment-at-3-and-4-dimensional-transperineal-ultrasound-in-women-with-endometriosis-with-or-without-retroperitoneal-infiltration-a-step-towards-complete-functional-assessment
#8
Mohamed Mabrouk, Diego Raimondo, Simona Del Forno, Federica Baruffini, Alessandro Arena, Arianna Benfenati, Aly Youssef, Valentina Martelli, Renato Seracchioli
OBJECTIVES: Previous studies, comparing women with deep infiltrating endometriosis (DIE) and healthy controls, underlined an association between pelvic floor muscle (PFM) hypertonic dysfunction and deep lesions. The aim of the study is to compare the morphometry of pelvic floor muscle (PFM) in women affected by ovarian endometriosis with or without DIE, to assess the impact of retroperitoneal infiltration by the disease on PFM function. METHODS: A prospective study was conducted between March 2015 to December 2016 on symptomatic women with clinical and sonographic diagnosis of ovarian endometriosis with or without DIE, submitted to laparoscopic surgery...
October 11, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29023327/sodium-bicarbonate-supplementation-delays-neuromuscular-fatigue-without-changes-in-performance-outcomes-during-a-basketball-match-simulation-protocol
#9
Paul Ansdell, Jeanne Dekerle
PURPOSE: To investigate the development of neuromuscular fatigue during a basketball game simulation and ascertain whether sodium bicarbonate (NaHCO3) supplementation attenuates any neuromuscular fatigue that persists. METHODS: Ten participants ingested 0.2 g.kg of NaHCO3 (or an equimolar placebo dosage of sodium chloride [NaCl]) 90 and 60 minutes prior to commencing a basketball game simulation (ALK-T vs PLA-T). Isometric maximal voluntary contractions of the knee extensors (MVIC) and potentiated high (100 Hz) and low (10 Hz) frequency doublet twitches were recorded before and after each match quarter for both trials...
October 10, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29023089/gelatin-polyaniline-composite-nanofibers-enhanced-excitation-contraction-coupling-system-maturation-in-myotubes
#10
Serge Ostrovidov, Majid Ebrahimi, Hojae Bae, Hung Kim Nguyen, Sahar Salehi, Sang Bok Kim, Akichika Kumatani, Tomokazu Matsue, Xuetao Shi, Ken Nakajima, Shizu Hidema, Makoto Osanai, Ali Khademhosseini
In this study, composite gelatin-polyaniline (PANI) nanofibers doped with camphorsulfonic acid (CSA) was fabricated by electrospinning and used as substrates to culture C2C12 myoblast cells. We observed enhanced myotube formation on composite gelatin-PANI nanofibers compared to gelatin nanofibers, concomitantly with enhanced myotube maturation. Thus, in myotubes, intracellular organization, co-localization of the dihydropyridine receptor (DHPR) and ryanodine receptor (RyR), expression of genes correlated to the excitation-contraction (E-C) coupling apparatus, calcium transients, and myotube contractibility were increased...
October 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29022707/bistable-c2-daisy-chain-rotaxanes-as-reversible-muscle-like-actuators-in-mechanically-active-gels
#11
Antoine Goujon, Thomas Lang, Giacomo Mariani, Emilie Moulin, Gad Fuks, Jesus Raya, Eric Buhler, Nicolas Giuseppone
The implementation of molecular machines in polymer science is of high interest to transfer mechanical motions from nanoscale to macroscale in order to access new kinds of active devices and materials. Towards this objective, thermodynamic and topological aspects need to be explored for reaching efficient systems capable of producing a useful work. In this paper we describe the branched polymerization of pH-sensitive bistable [c2]daisy chain rotaxanes by using copper (I) catalyzed Huisgen 1,3-dipolar cycloaddition ("click chemistry")...
October 12, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29022202/clove-oil-induces-anaesthesia-and-blunts-muscle-contraction-power-in-three-amazon-fish-species
#12
Rodrigo Yudi Fujimoto, Débora Martins Pereira, Jessica Cristina Souza Silva, Laís Cássia Araújo de Oliveira, Luis Antonio Kioshi Aoki Inoue, Moisés Hamoy, Vanessa Jóia de Mello, Marcelo Ferreira Torres, Luis André Luz Barbas
Clove oil is used as an anaesthetic for many species of fish worldwide; however, relatively few studies have assessed its effectiveness on Amazon fish species and no compelling evidence has ever been reported on the relaxant properties of this oil for skeletal muscle of fish. Thus, the objective of this study was to evaluate the latencies to deep anaesthesia and recovery, along with the myorelaxant effect of clove oil on three Amazon fish species: cardinal tetra, Paracheirodon axelrodi, banded cichlid, Heros severus and angelfish, Pterophyllum scalare, submitted to short-term anaesthetic baths...
October 12, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29021750/cough-anal-reflex-may-be-the-expression-of-a-pre-programmed-postural-action
#13
Paolo Cavallari, Francesco Bolzoni, Roberto Esposti, Carlo Bruttini
When coughing, an involuntary contraction of the external anal sphincter occurs, in order to prevent unwanted leakages or sagging of the pelvis muscular wall. Literature originally described such cough-anal response as a reflex elicited by cough, therefore identifying a precise cause-effect relationship. However, recent studies report that the anal contraction actually precedes the rise in abdominal pressure during cough expiratory effort, so that the sphincter activity should be pre-programmed. In recent years, an important family of pre-programmed muscle activities has been well documented to precede voluntary movements: these anticipatory actions play a fundamental role in whole body and segmental postural control, hence they are referred to as anticipatory postural adjustments (APAs)...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29021503/characterization-of-the-chemical-structure-and-innate-immune-stimulating-activity-of-an-extracellular-polysaccharide-from-rhizobium-sp-strain-m2-screened-using-a-silkworm-muscle-contraction-assay
#14
Makoto Urai, Tomoko Aizawa, Katsutoshi Imamura, Hiroshi Hamamoto, Kazuhisa Sekimizu
We screened innate immunostimulant-producing bacteria using a silkworm muscle contraction assay, and isolated Rhizobium sp. strain M2 from soil. We purified the innate immunostimulant from strain M2, and characterized the chemical structure by nuclear magnetic resonance spectroscopy and chemical analyses. The innate immunostimulant (M2 EPS) comprised glucose, galactose, pyruvic acid, and succinic acid with a molar ratio of 6.8:1.0:0.9:0.4, and had a succinoglycan-like high molecular-weight heteropolysaccharide structure...
October 11, 2017: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/29021502/structural-analysis-of-an-innate-immunostimulant-from-broccoli-brassica-oleracea-var-italica
#15
Makoto Urai, Keiko Kataoka, Satoshi Nishida, Kazuhisa Sekimizu
Vegetables are eaten as part of a healthy diet throughout the world, and some are also applied topically as a traditional medicine. We evaluated the innate immunostimulating activities of hot water extracts of various vegetables using the silkworm muscle contraction assay system, and found that broccoli, Brassica oleracea var. italica, contains a strong innate immunostimulant. We purified the innate immunostimulant from broccoli, and characterized the chemical structure by chemical analyses and NMR spectroscopy...
October 11, 2017: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/29021148/the-voltage-sensor-of-excitation-contraction-coupling-in-mammals-inactivation-and-interaction-with-ca-2
#16
Juan Ferreira Gregorio, Germán Pequera, Carlo Manno, Eduardo Ríos, Gustavo Brum
In skeletal muscle, the four-helix voltage-sensing modules (VSMs) of CaV1.1 calcium channels simultaneously gate two Ca(2+) pathways: the CaV1.1 pore itself and the RyR1 calcium release channel in the sarcoplasmic reticulum. Here, to gain insight into the mechanism by which VSMs gate RyR1, we quantify intramembrane charge movement associated with VSM activation (sensing current) and gated Ca(2+) release flux in single muscle cells of mice and rats. As found for most four-helix VSMs, upon sustained depolarization, rodent VSMs lose the ability to activate Ca(2+) release channels opening; their properties change from a functionally capable mode, in which the mobile sensor charge is called charge 1, to an inactivated mode, charge 2, with a voltage dependence shifted toward more negative voltages...
October 11, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/29018970/andersen-s-syndrome-mutants-produce-a-knockdown-of-inwardly-rectifying-k-channel-in-mouse-skeletal-muscle-in-vivo
#17
Dina Simkin, Gaëlle Robin, Serena Giuliano, Ana Vukolic, Pamela Moceri, Nicolas Guy, Kay-Dietrich Wagner, Alain Lacampagne, Bruno Allard, Saïd Bendahhou
Andersen's syndrome (AS) is a rare autosomal disorder that has been defined by the triad of periodic paralysis, cardiac arrhythmia, and developmental anomalies. AS has been directly linked to over 40 different autosomal dominant negative loss-of-function mutations in the KCNJ2 gene, encoding for the tetrameric strong inward rectifying K(+) channel KIR2.1. While KIR2.1 channels have been suggested to contribute to setting the resting membrane potential (RMP) and to control the duration of the action potential (AP) in skeletal and cardiac muscle, the mechanism by which AS mutations produce such complex pathophysiological symptoms is poorly understood...
October 10, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/29018954/the-importance-of-cutaneous-feedback-on-neural-activation-during-maximal-voluntary-contraction
#18
Carlos Cruz-Montecinos, Huub Maas, Carla Pellegrin-Friedmann, Claudio Tapia
PURPOSE: The purpose of this study was to investigate the importance of cutaneous feedback on neural activation during maximal voluntary contraction (MVC) of the ankle plantar flexors. METHODS: The effects of cutaneous plantar anaesthesia were assessed in 15 subjects and compared to 15 controls, using a one-day pre/post-repeated measures design. Cutaneous plantar anaesthesia was induced by lidocaine injection at the centre of forefoot, lateral midfoot, and heel...
October 10, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29018624/genome-methylation-and-regulatory-functions-for-hypoxic-adaptation-in-tibetan-chicken-embryos
#19
Yawen Zhang, Wenyu Gou, Jun Ma, Hongliang Zhang, Ying Zhang, Hao Zhang
Tibetan chickens have unique adaptations to the extreme high-altitude environment that they inhabit. Epigenetic DNA methylation affects many biological processes, including hypoxic adaptation; however, the regulatory genes for DNA methylation in hypoxic adaptation remain unknown. In this study, methylated DNA immunoprecipitation with high-throughput sequencing (MeDIP-seq) was used to provide an atlas of the DNA methylomes of the heart tissue of hypoxic highland Tibetan and lowland Chahua chicken embryos. A total of 31...
2017: PeerJ
https://www.readbyqxmd.com/read/29017022/isometric-parameters-in-the-monitoring-of-maximal-strength-power-and-hypertrophic-resistance-training
#20
Heikki Peltonen, Simon Walker, Anuliisa Lähitie, Keijo Häkkinen, Janne Avela
This study monitored strength-training adaptations via isometric parameters throughout 2×10 weeks of hypertrophic (HYP I+II) or 10 weeks maximum strength (MS) followed by 10 weeks power (P) training with untrained controls. Previously untrained men performed bilateral isometric leg press tests analyzed for peak force (MVC) and rate of force development (RFD) every 3.5-week. These parameters were compared to dynamic performance, voluntary and electrically-induced isometric contractions, muscle activity and cross-sectional area (CSA) in the laboratory before and after 10 and 20 weeks...
October 10, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
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