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Wound closure

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https://www.readbyqxmd.com/read/28729818/a-cooperative-copper-metal-organic-framework-hydrogel-system-improves-wound-healing-in-diabetes
#1
Jisheng Xiao, Siyu Chen, Ji Yi, Hao Zhang, Guillermo A Ameer
Chronic non-healing wounds remain a major clinical challenge that would benefit from the development of advanced, regenerative dressings that promote wound closure within a clinically relevant time frame. The use of copper ions has shown promise in wound healing applications possibly by promoting angiogenesis. However, reported treatments that use copper ions require multiple applications of copper salts or oxides to the wound bed, exposing the patient to potentially toxic levels of copper ions and resulting in variable outcomes...
January 5, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/28729536/weakened-il-15-production-and-impaired-mtor-activation-alter-dendritic-epidermal-t-cell-homeostasis-in-diabetic-mice
#2
Zhongyang Liu, Guangping Liang, Li Gui, Yashu Li, Meixi Liu, Yang Bai, Xiaorong Zhang, Xiaohong Hu, Jian Chen, Chibing Huang, Xusheng Liu, Gaoxing Luo, Jun Wu, Weifeng He
Diabetes is associated with impaired wound healing, which may be caused primarily by a deficiency in dendritic epidermal T cells (DETCs). In the epidermis, IL-15, IGF-1, and mTOR are known to regulate the maintenance of DETCs; however, it is unclear how these molecules may intersect to regulate DETC homeostasis in diabetes. Here, we show that the reduction of DETCs in the epidermis of diabetic mice is caused by altered homeostasis mediated by a reduction in IL-15 levels. Both impaired mTOR activation and reduction of IL-15 in the epidermis play important roles in DETC homeostasis...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28728869/aesthetic-outcome-and-complications-of-simple-interrupted-versus-running-subcuticular-sutures-in-facial-surgery-a-randomized-controlled-trial
#3
Xiaomeng Liu, Patty J Nelemans, Lisa D S Frenk, Helma Sengers, Stephania M H Tuinder, Peter M Steijlen, Klara Mosterd, Nicole W J Kelleners-Smeets
BACKGROUND: The suturing technique and its associated complications could affect cosmetic outcome after facial surgery. Literature on this topic is limited. OBJECTIVE: To compare the cosmetic results 12 months after treatment and complications associated with simple interrupted sutures (SIS) versus running subcuticular sutures (RSS) in facial surgery. METHODS: A randomized, controlled multicenter trial was performed. Adults receiving dermatologic surgery on the face were randomized to receive SIS or RSS for wound closure...
July 17, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28728333/the-lazy-s-design-a-novel-skin-closure-design-in-skin-sparing-mastectomy-for-implant-based-breast-reconstruction
#4
June-Kyu Kim, Yong Seong Kim
Preservation of the breast skin envelope during immediate implant-based breast reconstruction is important for producing symmetrical and natural-looking breasts. We propose the lazy S design for the closure of round-shaped wounds with the hope of improving the aesthetic outcomes and reducing the tension on the wound by preserving the skin. Additionally, the direction of tension is dispersed due to the shape of this design. Patients undergoing implant reconstruction after skin-sparing mastectomy may benefit from the lazy S design...
July 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/28728177/porcine-collagen-transconjunctival-wound-closure-system-for-microincisional-vitrectomy-surgery
#5
Tiffany A Chen, Peter K Kaiser, Rainer Fasching, Darius M Moshfeghi
BACKGROUND AND OBJECTIVE: Microincisional vitrectomy surgery has improved outcomes for vitrectomies; however, wound closure complications remain an important concern. The authors introduce a technique to improve transconjunctival wound closure in vitrectomy surgery. PATIENTS AND METHODS: The authors evaluated the efficacy of porcine collagen plugs on stopping leakage from sclerotomy test sites in vitro and in vivo and assessed wound site healing with histology samples...
July 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28727481/leucocyte-and-platelet-rich-fibrin-l-prf-as-a-regenerative-medicine-strategy-for-the-treatment-of-refractory-leg-ulcers-a-prospective-cohort-study
#6
Nelson R Pinto, Matias Ubilla, Yelka Zamora, Verónica Del Rio, David M Dohan Ehrenfest, Marc Quirynen
Chronic wounds (VLU: venous leg ulcer, DFU: diabetic foot ulcer, PU: pressure ulcer, or complex wounds) affect a significant proportion of the population. Despite appropriate standard wound care, such ulcers unfortunately may remain open for months or even years. The use of leukocyte- and platelet-rich fibrin (L-PRF) to cure skin ulcers is a simple and inexpensive method, widely used in some countries but unknown or neglected in most others. This auto-controlled prospective cohort study explored and quantified accurately for the first time the adjunctive benefits of topical applications of L-PRF in the management of such refractory ulcers in a diverse group of patients...
July 20, 2017: Platelets
https://www.readbyqxmd.com/read/28727170/entire-papilla-preservation-technique-in-the-regenerative-treatment-of-deep-intrabony-defects-1-year-results
#7
Serhat Aslan, Nurcan Buduneli, Pierpaolo Cortellini
AIM: This study evaluates the clinical performance of a novel tunnel-like surgical technique in the treatment of isolated deep intrabony defects. MATERIAL AND METHODS: Twelve patients presenting with at least one isolated deep intrabony defect received regenerative periodontal treatment with "entire papilla preservation" technique. Access to the intrabony defect for debridement was provided by a bevelled vertical releasing incision positioned in the buccal gingiva of the neighbouring interdental space...
July 20, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28726148/first-human-use-of-hybrid-synthetic-biologic-mesh-in-ventral-hernia-repair-a-multicenter-trial
#8
James G Bittner, Kevin El-Hayek, Andrew T Strong, Melissa Phillips LaPinska, Jin S Yoo, Eric M Pauli, Matthew Kroh
BACKGROUND: Mesh options for reinforcement of ventral/incisional hernia (VIH) repair include synthetic or biologic materials. While each material has known advantages and disadvantages, little is understood about outcomes when these materials are used in combination. This multicenter study reports on the first human use of a novel synthetic/biologic hybrid mesh (Zenapro(®) Hybrid Hernia Repair Device) for VIH repair. METHODS: This prospective, multicenter post-market clinical trial enrolled consecutive adults who underwent elective VIH repair with hybrid mesh placed in the intraperitoneal or retromuscular/preperitoneal position...
July 19, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28722024/multifunctional-nanoparticles-as-a-tissue-adhesive-and-an-injectable-marker-for-image-guided-procedures
#9
Kwangsoo Shin, Jin Woo Choi, Giho Ko, Seungmin Baik, Dokyoon Kim, Ok Kyu Park, Kyoungbun Lee, Hye Rim Cho, Sang Ihn Han, Soo Hong Lee, Dong Jun Lee, Nohyun Lee, Hyo-Cheol Kim, Taeghwan Hyeon
Tissue adhesives have emerged as an alternative to sutures and staples for wound closure and reconnection of injured tissues after surgery or trauma. Owing to their convenience and effectiveness, these adhesives have received growing attention particularly in minimally invasive procedures. For safe and accurate applications, tissue adhesives should be detectable via clinical imaging modalities and be highly biocompatible for intracorporeal procedures. However, few adhesives meet all these requirements. Herein, we show that biocompatible tantalum oxide/silica core/shell nanoparticles (TSNs) exhibit not only high contrast effects for real-time imaging but also strong adhesive properties...
July 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28720059/cervical-cancer-cell-derived-angiopoietins-promote-tumor-progression
#10
Ping Yang, Na Chen, Dongyun Yang, Janet Crane, Bangxing Huang, Ruiqing Dong, Xiaoqing Yi, Jing Guo, Jing Cai, Zehua Wang
Metastatic or recurrent cervical cancer has limited treatment options and a high rate of mortality. Although anti-vascular endothelial growth factor drugs have shown great promise as a therapeutic target for treatment of advanced cervical cancer, drug resistance and class-specific side effects negate long-term benefits. The identification of alternative anti-angiogenic factors will be critical for future drug development for advanced or recurrent cervical cancer. In this study, we found that angiopoietins and Tie receptors were highly expressed in cervical cancer cells...
July 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28718255/dural-tears-in-patients-with-depressed-skull-fractures
#11
Gul Muhammad, Ahsan Aurangzeb, Shahbaz Ali Khan, Iqbal Hussain, Sudhair Alam, Ehtisham Ahmed Khan Afridi, Baynazir Khan, Sajid Nazir Bhatti
BACKGROUND: The presence of skull fracture in patients sustaining traumatic brain injury is an important risk factor for intracranial lesions. Assessment of integrity of dura in depressed skull fracture is of paramount importance because if dura is torn, lacerated brain matter may be present in the wound which needs proper debridement followed by water tight dural closure to prevent meningitis, cerebral abscess, and pseudomeningocoele formation. The objective of this study was to determine the frequency of dural tear in patients with depressed skull fractures...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28717912/management-of-the-open-abdomen-after-liver-transplantation
#12
Christian Hobeika, Marc-Antoine Allard, Petru-Octav Bucur, Salima Naili, Antonio Sa Cunha, Daniel Cherqui, Denis Castaing, René Adam, Eric Vibert
INTRODUCTION: The optimal management of the open abdomen (OA) after liver transplantation (LT) is unclear. The negative pressure wound therapy (NPWT) has been shown to be safe and can increase the chance for early fascial closure in trauma or septic patients. However, little data are available on the specific setting of LT. We aimed to report our experience of OA after LT, marked by the recent use of NPWT. METHODS: All patients with postponed wall closure after LT, from 2002 to 2014, in a single institution were included and retrospectively analyzed...
July 17, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28717295/animal-inflicted-maxillofacial-injuries-treatment-modalities-and-our-experience
#13
Anjani Kumar Yadav, Mehul Rajesh Jaisani, Leeza Pradhan, Ashok Dongol, Arpita Singh, Pradeep Acharya, Alok Sagtani
INTRODUCTION: Animal inflicted injuries to the face and neck are becoming much more common as people lavish affection on pets. Injuries caused by animal attacks to the face can cause complex injuries to soft and hard tissues, presented as perforations, lacerations, crushes, avulsion or fractures. An uncountable number of bacteria and virus can be found in such injuries, with a potential pathological effect to humans, regarding infections. Although the infection rate is low due to excellent blood supply to face, the injuries have disfiguring effect with possible psychological repercussion to the patients...
September 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28715921/the-role-of-secreted-heat-shock-protein-90-hsp90-in-wound-healing-how-could-it-shape-future-therapeutics
#14
Jiacong Guo, Cheng Chang, Wei Li
Defects in tissue repair or wound healing pose a clinical, economic and social problem worldwide. Despite decades of studies, there have been few effective therapeutic treatments. Areas covered: We discuss the possible reasons for why growth factor therapy did not succeed. We point out the lack of human disorder-relevant animal models as another blockade for therapeutic development. We summarize the recent discovery of secreted heat shock protein-90 (Hsp90) as a novel wound healing agent. Expert commentary: Wound healing is a highly complex and multistep process that requires participations of many cell types, extracellular matrices and soluble molecules to work together in a spatial and temporal fashion within the wound microenvironment...
July 18, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28714933/macrophage-phenotypes-regulate-scar-formation-and-chronic-wound-healing
#15
REVIEW
Mark Hesketh, Katherine B Sahin, Zoe E West, Rachael Z Murray
Macrophages and inflammation play a beneficial role during wound repair with macrophages regulating a wide range of processes, such as removal of dead cells, debris and pathogens, through to extracellular matrix deposition re-vascularisation and wound re-epithelialisation. To perform this range of functions, these cells develop distinct phenotypes over the course of wound healing. They can present with a pro-inflammatory M1 phenotype, more often found in the early stages of repair, through to anti-inflammatory M2 phenotypes that are pro-repair in the latter stages of wound healing...
July 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28714284/egg-albumen-as-a-fast-and-strong-medical-adhesive-glue
#16
Kaige Xu, Yuqing Liu, Shousan Bu, Tianyi Wu, Qiang Chang, Gurankit Singh, Xiaojian Cao, Chuang Deng, Bingyun Li, Gaoxing Luo, Malcolm Xing
Sutures penetrate tissues to close wounds. This process leads to inflammatory responses, prolongs healing time, and increases operation complexity. It becomes even worse when sutures are applied to stress-sensitive and fragile tissues. By bonding tissues via forming covalent bonds, some medical adhesives are not convenient to be used by surgeons and have side effects to the tissues. Here egg albumen adhesive (EAA) is reported with ultrahigh adhesive strength to bond various types of materials and can be easily used without any chemical and physical modifications...
July 17, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28709667/routine-use-of-topical-bacitracin-to-prevent-sternal-wound-infections-after-cardiac-surgery
#17
Joshua L Chan, Andrada C Diaconescu, Keith A Horvath
BACKGROUND: The development of sternal wound infections remains a serious complication after cardiac surgery. A number of studies have assessed the use of topical antibiotics placed on the sternal edges. We evaluated the routine use of bacitracin ointment applied over the sternotomy skin incision as a prophylactic measure against sternal wound infections. METHODS: A retrospective review of all coronary artery bypass graft and valve surgery cases performed at a single institution between 2006 and 2015 was performed (n = 1,495)...
July 11, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28708024/quality-improvement-initiative-preventative-surgical-site-infection-protocol-in-vascular-surgery
#18
David Parizh, Enrico Ascher, Syed Ali Raza Rizvi, Anil Hingorani, Michael Amaturo, Eric Johnson
Objective A quality improvement initiative was employed to decrease single institution surgical site infection rate in open lower extremity revascularization procedures. SUMMARY BACKGROUND DATA: In an attempt to lower patient morbidity, we developed and implemented the Preventative Surgical Site Infection Protocol in Vascular Surgery. Surgical site infections lead to prolonged hospital stays, adjunctive procedure, and additive costs. We employed targeted interventions to address the common risk factors that predispose patients to post-operative complications...
January 1, 2017: Vascular
https://www.readbyqxmd.com/read/28706766/a-case-based-review-of-the-management-of-penetrating-brain-trauma
#19
Jason Milton, Alex Rugino, Kailash Narayan, Chris Karas, Victor Awuor
Principles of penetrating head trauma management were established by Harvey Cushing in relation to the management of penetrating brain injuries of World War One. Cushing radically debrided the scalp and skull and aggressively irrigated wound tracks to remove foreign bodies. He would then obtain water-tight closure. Cushing significantly decreased infection rates which reportedly limited the major cause of mortality due to penetrating head injuries. Many advances have been made by contributions from World War Two, Korean War, Vietnam War, and Iran/Iraq conflicts...
June 12, 2017: Curēus
https://www.readbyqxmd.com/read/28704719/biochemical-and-functional-analysis-of-corticotropin-releasing-factor-purified-from-an-aqueous-extract-of-human-placenta-used-as-wound-healer
#20
Namrata Singh, Debasish Bhattacharyya
Human placental extract constitutes of innumerable therapeutically important components mostly used in wound healing arising from the skin and burn injuries. However, there is still some bioactive present in the placental extracts yet to be characterized to better under the complex process of wound healing mediated by the placental extract. In this study, the presence of corticotropin releasing factor (CRF) in an aqueous extract of human placenta was detected and quantified by dot blot and CRF-ELISA immunoassay kit respectively...
June 28, 2017: Journal of Pharmaceutical and Biomedical Analysis
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