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https://www.readbyqxmd.com/read/29928075/can-drains-be-avoided-in-lipo-abdominoplasty
#1
Medha Anand Bhave
Context: Seroma formation is a common complication after lipoabdominoplasty. Conventionally, drains have been placed to prevent seroma; however, there are problems with drains, namely, pain, compromised mobilisation, breakage, tissue irritation and infection. Strategies to prevent seroma, such as the use of glue or quilting sutures have all been attempted with variable and unpredictable benefit. Aims: The author extrapolated the experience with own liposuction protocols to lipoabdominoplasty and began doing away with drains from the year 2006 onwards unless absolutely indicated...
January 2018: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/29927863/endoscopic-esophageal-vacuum-therapy-a-novel-therapy-for-esophageal-perforations-in-pediatric-patients
#2
Michael A Manfredi, Susannah J Clark, Steven J Staffa, Peter D Ngo, C Jason Smithers, Thomas E Hamilton, Russell W Jennings
BACKGROUND: Esophageal perforation is a potentially life-threatening problem if not quickly diagnosed and treated appropriately. Negative pressure wound therapy (NPWT), commercially known as V.A.C.® therapy, was developed in the early 1990 s and is now standard of care for chronic surface wounds, ulcers, and burns. Adapting vacuum sponge therapy for use intraluminally for perforations of the esophagus was first reported in 2008. We report the first pediatric experience on a customized esophageal vacuum assisted closure (EVAC) device for closure of esophageal perforations...
June 20, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29924890/targeting-mmp-13-in-bronchial-epithelial-repair
#3
Christopher Howell, James R Smith, Janis K Shute
BACKGROUND: Viral infection of the bronchial epithelium disrupts the barrier properties of the epithelium in healthy individuals and those with lung disease. Repair of the bronchial epithelium is dependent of the formation of a provisional fibrin matrix and migration of epithelial cells to cover denuded areas, followed by proliferation and differentiation. OBJECTIVE: The objective was to test the hypothesis that poly I:C, a model of viral infection, limits epithelial repair through the stimulated release of matrix metalloproteinase-13 (MMP-13)...
June 20, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29924595/angiogenesis-and-full-thickness-wound-healing-efficiency-of-copper-doped-borate-bioactive-glass-poly-lactic-co-glycolic-acid-dressing-loaded-with-vitamin-e-in-vivo-and-in-vitro
#4
Haoran Hu, Yue Tang, Libin Pang, Cunlong Lin, Wenhai Huang, Deping Wang, Weitao Jia
There is an urgent demand for wound healing biomaterials because of the increasing frequency of traffic accidents, industrial contingencies and natural disasters. Borate bioactive glass has potential applications in bone tissue engineering and wound healing; however, its uncontrolled release runs a high risk of rapid degradation and transient biotoxicity. In this study, a novel organic-inorganic dressing of copper-doped borate bioactive glass/poly(lactic-co-glycolic acid) loaded with vitamin E (0-3.0 wt.% vitamin E) was fabricated to evaluate its efficiency for angiogenesis in cells and full-thickness skin wounds healing in rodents...
June 20, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29923977/comparison-of-leukosan-skinlink-with-surgical-suture-for-traumatic-laceration-repair-a-randomized-controlled-trial
#5
Hyeongtae Kim, Wonhee Kim, Gu Hyun Kang, Yong Soo Jang, Hyun Young Choi, Jae Guk Kim, In Young Kim, Minji Kim
BACKGROUND: Leukosan SkinLink (LS), which combines non-woven textile strips and tissue adhesive, offers the advantage of atraumatic treatment while effectively shortening the procedure time. We hypothesized that wound closure would be faster with LS than with surgical suture (SS) and the wound infection and dehiscence would be similar. METHODS: A prospective, open label, single-center, randomized controlled trial was performed. Between November 2014 and April 2016, 49 patients with traumatic lacerations who presented to the emergency department were eligible for study inclusion...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923900/evaluating-a-surfactant-containing-polymeric-membrane-foam-wound-dressing-with-glycerin-in-patients-with-chronic-pilonidal-sinus-disease
#6
R Gary Sibbald, Reneeka Persaud Jaimangal, Patricia M Coutts, James A Elliott
GENERAL PURPOSE: To present an evaluation of a surfactant-containing polymeric membrane foam wound dressing for use on patients with chronic pilonidal sinus disease. TARGET AUDIENCE: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care. LEARNING OBJECTIVES/OUTCOMES: After completing this continuing education activity, you should be able to:1...
July 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29923841/comprehensive-review-of-tissue-adhesives
#7
Lauren E Jenkins, Loretta S Davis
BACKGROUND: Cyanoacrylates, also known as tissue adhesives or skin glues, are commonly used as sealants for lacerations and incisions and have found utility in excisional and cosmetic surgeries in both outpatient and operating room settings. OBJECTIVE: To review the surgical literature on the utilities, advantages, disadvantages, and special uses of cyanoacrylates applicable to dermatology. MATERIALS AND METHODS: PubMed was reviewed for relevant articles related to cyanoacrylates and their use in skin closures...
June 19, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29923073/perioperative-platelet-rich-plasma-prp-in-total-hip-arthroplasty-through-the-hardinge-approach-protocol-to-study-the-effectiveness-for-gluteus-medius-healing
#8
Anni Aavikko, J Puhakka, J Haapala, J Kukkonen, K Mäkelä, J Kosola
BACKGROUND: Platelet-rich plasma (PRP) has been used to support tendon regeneration mainly in sports medicine. PRP is a concentrate of platelet-rich plasma proteins derived from whole blood by centrifugation to remove erythrocytes and leukocytes. PRP has high amounts of platelets which may promote healing tendons affected by degenerative conditions. These platelets contain growth factors and are known to facilitate the regeneration of injured tendon structures. Total hip arthroplasty (THA) through the Hardinge approach may leave the patient with impaired gait and poor regeneration of the gluteus medius tendon if the tendon is not reattached properly after closure of the surgical wound...
June 19, 2018: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29922560/the-utility-of-silk-elastin-hydrogel-as-a-new-material-for-wound-healing
#9
Shingo Kawabata, Norikazu Kanda, Yasushi Hirasawa, Kazuo Noda, Yoshitaka Matsuura, Shigehiko Suzuki, Katsuya Kawai
Cutaneous ulcers are treated with dressing materials and/or ointments to keep the wound in an appropriately moist environment. However, chronic cutaneous ulcers commonly have bacterial colonization that can cause local infection in such an environment. Therefore, the dressing materials and/or ointments should have antibacterial potency to treat chronic ulcers. Acute cutaneous wounds, by contrast, heal rapidly without local infection. The aim of treating acute cutaneous wounds is therefore not only wound closure but also preventing scar contracture after wound healing...
May 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29916223/ankaferd-blood-stopper-with-antibiofilm-potential-successfully-inhibits-the-extracellular-matrix-degradation-enzymes-and-promotes-wound-healing-of-3t3-fibroblasts-in-vitro
#10
Rukiye Boran, Tuba Baygar, Nurdan Saraç, Aysel Uğur
Background/aim: The potential inhibitory effects of Ankaferd Blood Stopper (ABS) against biofilm formation of oral microorganisms and its capacity for collagenase, hyaluronidase, and elastase inhibitions that have important roles in wound healing have been investigated. Materials and methods: The wound healing potential was determined by its inhibition ability on collagenase, hyaluronidase, and elastase enzyme activities and was evaluated via scratch wound healing assay on murine 3T3 fibroblasts. The antibiofilm activity was tested against eight oral microorganisms using the crystal violet staining method...
June 14, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29915432/%C3%AF-editors-choice%C3%AF-effects-of-exosomes-derived-from-the-induced-pluripotent-stem-cells-on-skin-wound-healing
#11
Hitoshi Kobayashi, Katsumi Ebisawa, Miki Kambe, Takatoshi Kasai, Hidetaka Suga, Kae Nakamura, Yuji Narita, Aika Ogata, Yuzuru Kamei
Recently, the effects of stem cell supernatants or exosomes, such as skin wounds, have attracted attention. However, the effects of the induced pluripotent stem (iPS) cell-derived exosomes (iPS-Exos) have not been investigated in detail. Here, we investigated the effects of iPS-Exos on skin wound healing using an animal model. We isolated iPS-Exos from the iPS cell culture media. Control exosomes were isolated from unused iPS cell culture media (M-Exos). We first observed the morphologic characteristics of the isolated exosomes and examined the expression of surface antigens...
May 2018: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29914183/graviola-annona-muricata-exerts-anti-proliferative-anti-clonogenic-and-pro-apoptotic-effects-in-human-non-melanoma-skin-cancer-uw-bcc1-and-a431-cells-in-vitro-involvement-of-hedgehog-signaling
#12
Jean Christopher Chamcheu, Islam Rady, Roxane-Cherille N Chamcheu, Abu Bakar Siddique, Melissa B Bloch, Sergette Banang Mbeumi, Abiola S Babatunde, Mohammad B Uddin, Felicite K Noubissi, Peter W Jurutka, Yong-Yu Liu, Vladimir S Spiegelman, G Kerr Whitfield, Khalid A El Sayed
Non-melanoma skin cancers (NMSCs) are the leading cause of skin cancer-related morbidity and mortality. Effective strategies are needed to control NMSC occurrence and progression. Non-toxic, plant-derived extracts have been shown to exert multiple anti-cancer effects. Graviola ( Annona muricata ), a tropical fruit-bearing plant, has been used in traditional medicine against multiple human diseases including cancer. The current study investigated the effects of graviola leaf and stem extract (GLSE) and its solvent-extracted fractions on two human NMSC cell lines, UW-BCC1 and A431...
June 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29914066/connexin-43-based-therapeutics-for-dermal-wound-healing
#13
REVIEW
Jade Montgomery, Gautam S Ghatnekar, Christina L Grek, Kurtis E Moyer, Robert G Gourdie
The most ubiquitous gap junction protein within the body, connexin 43 (Cx43), is a target of interest for modulating the dermal wound healing response. Observational studies found associations between Cx43 at the wound edge and poor healing response, and subsequent studies utilizing local knockdown of Cx43 found improvements in wound closure rate and final scar appearance. Further preclinical work conducted using Cx43-based peptide therapeutics, including alpha connexin carboxyl terminus 1 (αCT1), a peptide mimetic of the Cx43 carboxyl terminus, reported similar improvements in wound healing and scar formation...
June 15, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29911427/tie-over-bolster-dressings-vs-basting-sutures-for-the-closure-of-full-thickness-skin-grafts-a-review-of-the-literature
#14
William Kromka, Michael Cameron, Ramin Fathi
BACKGROUND: Full-thickness skin grafting is a well-established technique in the reconstruction of various tissue defects and wounds. However, lack of uniformity in the procedure of closing and securing the grafts has led to a wide range of different techniques. OBJECTIVE: This article reviews the use of tie-over bolster dressings compared to basting sutures for the fixation and postsurgical immobilization of full-thickness skin grafts (FTSGs), discusses details of each method, and proposes a practice guideline for the closure of FTSGs...
June 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29910997/periodontal-treatment-in-cancer-patients-an-interdisciplinary-approach
#15
A M Decker, L S Taichman, N J D'Silva, R S Taichman
Purpose of Review: Dental care is an essential component in the comprehensive treatment for the cancer patient. As such, a review of the literature was completed to determine the relationships between periodontal and dental care in the cancer patient and provide strategic suggestions. Recent Findings: Periodontal treatment must be personalized depending on the patient's current oral health status, systemic status, and progress in treatment. Oral mucositis, periodontal status, and osteonecrosis of the jaw (ONJ) remain periodontal concerns in the cancer patient...
March 2018: Current Oral Health Reports
https://www.readbyqxmd.com/read/29910106/deep-inferior-epigastric-perforator-diep-flap-impact-of-drain-free-donor-abdominal-site-on-long-term-patient-outcomes-and-duration-of-inpatient-stay
#16
Amitabh Thacoor, Muholan Kanapathy, Jana Torres-Grau, Jagdeep Chana
BACKGROUND: The deep inferior epigastric perforator (DIEP) flap is widely regarded as the Gold Standard in autologous breast reconstruction. Although drain-free abdominoplasty is performed in many centres, there is a paucity of evidence comparing outcomes when applied to DIEP breast reconstruction. METHOD: A retrospective review of patients who underwent DIEP breast reconstruction without abdominal drain insertion at Royal Free Hospital between Jan 2012-Nov 2016 was undertaken...
May 22, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29909854/retrograde-administration-of-ultrasound-guided-endovenous-microfoam-chemical-ablation-for-the-treatment-of-superficial-venous-insufficiency
#17
Steven T Deak
OBJECTIVE: This study measured patient outcomes among symptomatic patients with superficial chronic venous insufficiency who were treated with retrograde ultrasound-guided polidocanol microfoam 1% in a community setting. METHODS: Between March 2015 and June 2017, 250 symptomatic patients with C2-C6 chronic venous insufficiency received polidocanol microfoam 1% and were followed for 16 ± 7 months. Sixteen of the 250 patients (6.4%) had skin ulcers, and 56 (22...
July 2018: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29908640/comparative-study-of-regenerative-effects-of-mesenchymal-stem-cells-derived-from-placental-amnion-chorion-and-umbilical-cord-on-dermal-wounds
#18
Juliane Ertl, Melanie Pichlsberger, Alexandru-Cristian Tuca, Paul Wurzer, Jakob Fuchs, Stefan H Geyer, Barbara Maurer-Gesek, Wolfgang J Weninger, Dagmar Pfeiffer, Vladimir Bubalo, Daryousch Parvizi, Lars-Peter Kamolz, Ingrid Lang
OBJECTIVE: Mesenchymal stem/stromal cells derived from human term placentas (PMSCs) are novel therapeutic agents and more topical than ever. Here we evaluated the effects of three types of PMSCs on wound healing in an in vivo mouse model: Amnion-derived MSCs (AMSCs), blood vessel-derived MSCs (BV-MSCs) from the chorionic plate and Wharton's jelly-derived MSCs (WJ-MSCs) from the umbilical cord. METHODS: We topically applied PMSCs onto skin wounds in mice using the dermal substitute Matriderm® as carrier and evaluated wound healing parameters...
May 2018: Placenta
https://www.readbyqxmd.com/read/29907107/complete-abdominal-wound-and-anastomotic-leak-with-diffuse-peritonitis-closure-achieved-by-an-abdominal-vacuum-sealing-drainage-in-a-critical-ill-patient-a-case-report
#19
Yusuke Fujii, Yoshitsugu Tajima, Shunsuke Kaji, Takashi Kishi, Yoshiko Miyazaki, Takahito Taniura, Noriyuki Hirahara
BACKGROUND: Negative pressure wound therapy (NPWT) is a widely accepted technique to treat local infectious wounds of the skin, subcutaneous tissue, fascia, or muscle. Recently, several reports describing the efficacy of NPWT for various types of fistulas and anastomotic leaks have been published. We herein describe a patient with an open abdominal wound due to colonic anastomotic leakage and diffuse peritonitis, in whom abdominal vacuum sealing (AVS) as a modified NPWT was useful for the management of this complex wound...
June 15, 2018: BMC Surgery
https://www.readbyqxmd.com/read/29906231/role-of-endothelial-microrna-23-clusters-in-angiogenesis-in-vivo
#20
Satoshi Oikawa, Shogo Wada, Minjung Lee, Seiji Maeda, Takayuki Akimoto
The capillary network is distributed throughout the body, and its reconstruction is induced under various pathophysiological conditions. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression via post-transcriptional mechanisms and are involved in many biological functions including angiogenesis. Previous studies have shown that each miRNA of the miR-23 cluster, composed of the miR-23a cluster (miR-23a~27a~24-2) and miR-23b cluster (miR-23b~27b~24-2), regulates angiogenesis in vitro. However, the role of the endothelium-specific miR-23 cluster, located within a single transcription unit, in angiogenesis in vivo has not been elucidated...
June 15, 2018: American Journal of Physiology. Heart and Circulatory Physiology
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