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Wound closure

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https://www.readbyqxmd.com/read/29667150/topical-application-of-omega-3-omega-6-and-omega-9-rich-oil-emulsions-for-cutaneous-wound-healing-in-rats
#1
Wan Maznah Wan Ishak, Haliza Katas, Ng Pei Yuen, Maizaton Atmadini Abdullah, Mohd Hanif Zulfakar
Wound healing is a physiological event that generates reconstitution and restoration of granulation tissue that ends with scar formation. As omega fatty acids are part of membrane phospholipids and participate in the inflammatory response, we investigated the effects of omega-3, omega-6, and omega-9 fatty acids in the form of oils on wound healing. Linseed (LO), evening primrose (EPO), and olive oils (OO) rich in omega-3, omega-6, and omega-9 fatty acids were formulated into emulsions and were topically applied on rats with excision wounds...
April 17, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29663583/a-mathematical-model-for-the-determination-of-mouse-excisional-wound-healing-parameters-from-photographic-data
#2
Nicholas G Cogan, Alana P Mellers, Bhavi N Patel, Brett D Powell, Manu Aggarwal, Kathleen M Harper, Michael Blaber
We present a mathematical model to quantify parameters of mouse excisional wound healing from photographic data. The equation is a piecewise linear function in log scale that includes key parameters of initial wound radius (R0 ), an initial wound stasis phase (Ti ), and time to wound closure (Tc ); subsequently, these terms permit calculation of a latter active proliferative phase (Tp ), and the healing rate (HR) during this active phase. A daily photographic record of wound healing (utilizing 6 mm diameter splinted excisional wounds) permits the necessary sampling for robust parameter refinement...
April 17, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29662762/local-administration-of-trolox-a-vitamin-e-analog-reduced-tendon-adhesion-in-a-chicken-model-of-flexor-digitorum-profundus-tendon-injury
#3
Yuk Wa Lee, Sai Chuen Fu, Tsui Yu Mok, Kai Ming Chan, Leung Kim Hung
Background: Hand flexor tendon injuries are compromised with tendon adhesion. Tendon adhesion forms between flexor tendon and tendon sheath, reduces the range of motion of fingers, and affects their function. Oxidative stress is increased in flexor tendon after injury and might play a role in tendon adhesion formation. Trolox (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid), a water-soluble analog of vitamin E, is antioxidative. Trolox reduced oxidative stress and the expression of fibrotic cytokines in the bile gut ligation animal model...
July 2017: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29660746/free-versus-pedicled-perforator-flaps-for-lower-extremity-reconstruction-a-multicenter-comparison-of-institutional-practices-and-outcomes
#4
Keith Koh, Terence L H Goh, Christopher Tam Song, Hyun Suk Suh, Peter V Rovito, Joon-Pio Hong, Geoffrey G Hallock
BACKGROUND:  Of all body regions, lower extremity wounds have been and remain the greatest challenge. Perforator free flaps have been accepted as a reasonable option to solve this dilemma but require the complexity of microsurgery. As a consequence, the possibility that pedicled perforator flaps could supplant even perforator free flaps has recently gained intense enthusiasm. METHODS:  A retrospective investigation was undertaken to compare the validity for the use of perforator flaps of all types at three dissimilar institutions, that is, a university, a regional center, and a community hospital...
April 16, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29660154/local-mepivacaine-before-castration-of-horses-under-medetomidine-isoflurane-balanced-anaesthesia-is-effective-to-reduce-perioperative-nociception-and-cytokine-release
#5
M Abass, S Picek, J F Glaus Carzòn, C Kühnle, A Zaghlou, R Bettschart-Wolfensberger
BACKGROUND: In horses castration with primary intention healing is usually performed under balanced inhalation anaesthesia. To optimise analgesia, the use of local anaesthesia was tested. OBJECTIVES: To investigate the effect of local mepivacaine before castration with first intention healing under balanced medetomidine-isoflurane anaesthesia and flunixin meglumine, morphine analgesia on perioperative cytokine levels and pain in horses. STUDY DESIGN: Prospective blinded clinical study...
April 16, 2018: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29659146/curcumin-accelerates-cutaneous-wound-healing-via-multiple-biological-actions-the-involvement-of-tnf-%C3%AE-mmp-9-%C3%AE-sma-and-collagen
#6
Yu-Hsiu Yen, Chi-Ming Pu, Chen-Wei Liu, Ya-Chun Chen, Yu-Chen Chen, Chan-Jung Liang, Jung-Hsien Hsieh, Hui-Fu Huang, Yuh-Lien Chen
Curcumin, a constituent of the turmeric plant, has antitumor, anti-inflammatory, and antioxidative effects, but its effects on wound healing are unclear. We created back wounds in 72 mice and treated them with or without topical curcumin (0.2 mg/mL) in Pluronic F127 gel (20%) daily for 3, 5, 7, 9, and 12 days. Healing in wounds was evaluated from gross appearance, microscopically by haematoxylin and eosin staining, by immunohistochemistry for tumour necrosis factor alpha and alpha smooth muscle actin, and by polymerase chain reaction amplification of mRNA expression levels...
April 16, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29657934/comparison-of-wound-tape-and-suture-wounds-on-traumatic-wounds-scar
#7
Mehrdad Esmailian, Reza Azizkhani, Aliakbar Jangjoo, Mehdi Nasr, Sirous Nemati
Background: Several methods have been used in wound closure for traumatic wounds, but it is not clear that which of these methods has more safety and efficacy. This study aimed to compare scar width due to standard and current treatments in wound repair by suturing and method of wound restoration using wound tape in patients with traumatic ulcers. Materials and Methods: This randomized clinical trial was done in ninety patients with wounds in the facial area. They were divided randomly into two groups of 45...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29657907/comparing-surgical-site-infection-and-scar-cosmesis-between-conventional-linear-skin-closure-versus-purse-string-skin-closure-in-stoma-reversal-a-randomized-controlled-trial
#8
Sathasivam Sureshkumar, Kunnathoor Jubel, Manwar S Ali, Chellappa Vijayakumar, Anandhi Amaranathan, Sudharsanan Sundaramoorthy, Chinnakali Palanivel
Introduction Stoma closure is one of the most frequently performed surgeries. The common complications are surgical site infection (SSI) and poor scar cosmesis. Purse-string sutures are expected to have less incidence of SSI due to the free drainage of secretions from the wound and possibly the early detection of a wound infection. Compared to the conventional linear closure, the purse-string closure technique is expected to have less wound infection, improved scar cosmesis, and good patient satisfaction because of a smaller size scar...
February 11, 2018: Curēus
https://www.readbyqxmd.com/read/29656516/mir-21-ameliorates-aged-associated-skin-wound-healing-defects-in-mice
#9
Shuang Long, Na Zhao, Lan Ge, Guojian Wang, Xinze Ran, Junping Wang, Yongping Su, Tao Wang
BACKGROUND: The cellular and molecular mechanisms for aged-associated delay of cutaneous wound healing are still not well understood. Our previous results show that miR-21 plays key roles during skin wound healing. We presumed that dysregulation of miR-21 may involve in aged-associated defects in wound healing and miR-21 may be one potential therapeutic target to ameliorate wound defects in elderly subjects. METHODS: Circular full thickness excisional wounds were made on the dorsal skin of young (2-month-old) and aged (12-month-old) female mice...
April 15, 2018: Journal of Gene Medicine
https://www.readbyqxmd.com/read/29656072/enhanced-wound-healing-of-tissue-engineered-human-corneas-through-altered-phosphorylation-of-the-creb-and-akt-signal-transduction-pathways
#10
Camille Couture, Pascale Desjardins, Karine Zaniolo, Lucie Germain, Sylvain L Guérin
The cornea is a transparent organ, highly specialized and unique that is continually subjected to abrasive forces and occasional mechanical or chemical trauma because of its anatomical localization. Upon injury, the extracellular matrix (ECM) rapidly changes to promote wound healing through integrin-dependent activation of specific signal transduction mediators whose contribution is to favor faster closure of the wound by altering the adhesive and migratory properties of the cells surrounding the damaged area...
April 12, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29651853/oleogel-s10-to-accelerate-healing-of-donor-sites-monocentric-results-of-phase-iii-clinical-trial
#11
B Lipový, M Fiamoli, R Mager, Z Jelínková, J Jarkovský, Z Chaloupková, J Holoubek, I Suchánek, P Brychta
MATERIAL AND METHODS: Oleogel-S10, an ointment containing betulin-rich triterpene dry extract from birch bark was tested in an open, blindly evaluated, prospective, controlled, randomized multicentre study to improve wound healing in donor sites. The primary endpoint was time to wound closure, and secondary endpoints were scar related measurements at the time of wound closure, and 3 and 12 months after wound closure (POSAS, laser speckle contrast analysis, viscoelastic analysis). RESULTS: We report the results from a single centre (Department of Burns and Reconstructive Surgery, University Hospital Brno) of this phase III clinical trial...
2018: Acta Chirurgiae Plasticae
https://www.readbyqxmd.com/read/29649067/outpatient-negative-pressure-wound-therapy-following-surgical-debridement-results-and-complications
#12
Eran Tamir, Aharon S Finestone, Itay Wiser, Yoram Anekstein, Gabriel Agar
OBJECTIVE: To present results and complications in a case series of outpatients with diabetic and neuropathic foot ulcers with exposed bone following surgical debridement treated with negative-pressure wound therapy (NPWT). METHODS: Retrospective data were obtained from digital medical records from the Maccabi Health Services High Risk Foot Clinic in Tel Aviv, Israel, between 2009 and 2014. Medical records examined were those of clinic outpatients with exposed bone following partial foot amputation or selective bone debridement (University of Texas grade III-A) treated with NPWT...
April 11, 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29644315/limb-salvage-and-reconstruction-following-a-zebra-attack
#13
Jacob T Carlson, James C Yuen, Matthew R Smeds
Animal bites are fairly rare events but can cause devastating traumatic injuries to the victim. In addition to the soft tissue, vascular, and orthopedic trauma inflicted by these occurrences, bite injuries also have the potential to introduce an inoculum of microbes, which may progress to an infection if not treated properly and expeditiously. We present the case of a healthy male who sustained multiple bite wounds from a domestic zebra to his left upper extremity. This attack caused severe damage, including devascularization of the arm at the brachial artery, disruption of the distal biceps and brachialis, stripping of the forearm nerves, and shearing of the overlying soft tissue...
June 2017: Trauma Case Reports
https://www.readbyqxmd.com/read/29644299/surgical-management-of-compartment-syndrome-and-the-gradual-closure-of-a-fasciotomy-wound-using-a-dermaclose-device
#14
Gregory C Manista, Andrew Dennis, Matthew Kaminsky
The immediate recognition and timely response of compartment syndrome due to damage caused by penetrating trauma has immense clinical outcomes. The following is a case report of a complicated fasciotomy in a 33-year-old male who suffered a gunshot wound to his left lower extremity and the surgical management leading to adequate limb salvage and recovery.
April 2018: Trauma Case Reports
https://www.readbyqxmd.com/read/29644281/thyrohyoid-membrane-transection-caused-by-a-stab-injury
#15
Dongsub Noh, Kwang Hee Yeo, Hyun Min Cho, Chan Yong Park
Background: The thyrohyoid membrane is located between the hyoid bone and thyroid cartilage. Transection of the thyrohyoid membrane can be fatal. Case presentation: A 54-year-old man presented to the emergency room after attempting to commit suicide by cutting his neck. An endotracheal tube was inserted through the thyrohyoid membrane, which had been cut almost completely. After a tracheostomy, temporary wound closure was performed due to coagulopathy caused by hemorrhagic shock...
December 2017: Trauma Case Reports
https://www.readbyqxmd.com/read/29644146/xanthine-oxidoreductase-a-novel-therapeutic-target-for-the-treatment-of-chronic-wounds
#16
REVIEW
Melissa L Fernandez, Dario Stupar, Tristan Croll, David Leavesley, Zee Upton
Significance: Chronic wounds are a major burden to patients and to healthcare systems worldwide. These wounds are difficult to heal and treatment is often lengthy and expensive. This has led to research efforts focussed on the wound environment attempting to understand the underlying pathological mechanisms of impaired wound healing. While some of this research has translated to advancements in wound therapies and implementation of new treatment options, chronic wounds remain a significant challenge to treat...
March 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29644144/comparative-effectiveness-of-a-bioengineered-living-cellular-construct-and-cryopreserved-cadaveric-skin-allograft-for-the-treatment-of-venous-leg-ulcers-in-a-real-world-setting
#17
Terry Treadwell, Michael L Sabolinski, Michelle Skornicki, Nathan B Parsons
Objective: A variety of advanced biological therapies are available for the treatment of chronic wounds such as venous leg ulcers (VLUs), but real-world comparative effectiveness data that can help guide decisions around treatments are currently lacking. Approach: This analysis was designed to compare the effectiveness of a bioengineered living cellular construct (BLCC) to a cryopreserved cadaveric skin allograft (CCSA) for the treatment of VLUs. Treatment records were collected from a large wound care-specific electronic medical record database on 717 patients (799 VLUs) receiving treatment at 177 wound care centers...
March 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29643877/comparison-between-primary-closure-with-limberg-flap-versus-open-procedure-in-treatment-of-pilonidal-sinus-in-terms-of-frequency-of-post-operative-wound-infection
#18
Muhammad Sohail Jabbar, Mahwish Mahboob Bhutta, Nayyab Puri
Objective: Pilonidal sinus is a disorder of the sacrococcygeal region affecting younger individuals with a higher hair and weight distribution. Treatment involves the use of various surgical modalities, most of which are associated with a high rate of complications. Open procedure (OP) and Limberg Flap (LF) are two commonly performed surgical procedures for the correction of pilonidal sinus disease in our setup. The objective of our study was to compare the treatment of pilonidal sinus disease by primary closure with Limberg Flap verses Open procedure in terms of frequency of postoperative wound infection...
January 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29628696/do-local-antibiotics-reduce-periprosthetic-joint-infections-a-retrospective-review-of-744-cases
#19
Craig Winkler, Joel Dennison, Adam Wooldridge, Eneko Larumbe, Cyrus Caroom, Mark Jenkins, George Brindley
Periprosthetic joint infections (PJI) are uncommon but not rare and have significant morbidity and financial implications. Local antibiotics have been used successfully in other areas of orthopedics to reduce postoperative infections, but this method has not been proven in total joint arthroplasty (TJA). Beginning January 1, 2014, our primary investigators began using surgical site lavage with providone-iodine solution and administering 2 g of vancomcyin powder in the surgical wound prior to capsule closure for all primary and revision total hip and knee arthroplasties...
March 2018: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29627154/how-to-close-classic-bladder-exstrophy-are-subspecialty-training-and-technique-important
#20
Brian M Inouye, J Todd Purves, Jonathan C Routh, Mahir Maruf, Daniel Friedlander, John Jayman, John P Gearhart
INTRODUCTION: Successful primary closure is one of the main factors for achieving continence in a classic bladder exstrophy (CBE) patient. Even with contemporary management, patients still have failed primary closures. We sought to understand the role of training, surgical technique, and their impacts on outcomes of CBE closure. MATERIALS AND METHODS: A retrospective cohort study from the largest single-institution database of primary and re-closure CBE patients in the world was performed...
March 29, 2018: Journal of Pediatric Urology
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