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https://www.readbyqxmd.com/read/29342882/implication-of-soluble-forms-of-cell-adhesion-molecules-in-infectious-disease-and-tumor-insights-from-transgenic-animal-models
#1
REVIEW
Etsuro Ono, Toshimitsu Uede
Cell adhesion molecules (CAMs) are surface ligands, usually glycoproteins, which mediate cell-to-cell adhesion. They play a critical role in maintaining tissue integrity and mediating migration of cells, and some of them also act as viral receptors. It has been known that soluble forms of the viral receptors bind to the surface glycoproteins of the viruses and neutralize them, resulting in inhibition of the viral entry into cells. Nectin-1 is one of important CAMs belonging to immunoglobulin superfamily and herpesvirus entry mediator (HVEM) is a member of the tumor necrosis factor (TNF) receptor family...
January 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29326294/guillain-barr%C3%A3-syndrome-in-southern-china-retrospective-analysis-of-hospitalised-patients-from-14-provinces-in-the-area-south-of-the-huaihe-river
#2
Shuping Liu, Zheman Xiao, Min Lou, Fang Ji, Bei Shao, Hongyuan Dai, Can Luo, Bo Hu, Ruiling Zhou, Zhangyu Zou, Jing Li, Xiaoyi Li, Jun Xu, Fan Hu, Chao Qin, Lian Wang, Tao Liu, Runtao Bai, Yangmei Chen, Haiyan Lv, Ruxu Zhang, Xiaoming Wang, Yunfu Wang, Shanling Ren, Xiaoming He, Zhenwei Jiang, Huiwen Wu, Donghui Yu, Wenqiong Yang, Wenjing Luo, Daokai Gong, Bin Chen, Yin Liu, Jiajia Yao, Yujie Yang, Jingxia Guan, Mingzhen Zhu, Xiujuan Fu, Genshan Gao, Hong Zhang, Man Ding, Shanghua Fan, Qian Cao, Jingyi Lu, Zuneng Lu
OBJECTIVES: The clinical and epidemiological profiles of Guillain-Barré syndrome (GBS) in southern China have yet to be fully recognised. We aimed to investigate the subtypes of GBS in southern China, compare the clinical features of demyelinating form with that of axonal form and test whether preceding infections and age have influence on the clinical phenotype, disease course and severity of GBS. METHODS: Medical records of patients with a diagnosis of GBS admitted to 31 tertiary hospitals, located in 14 provinces in southern China, from 1 January 2013 to 30 September 2016, were collected and retrospectively reviewed...
January 11, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29323278/structural-biology-of-zika-virus-and-other-flaviviruses
#3
REVIEW
S Saif Hasan, Madhumati Sevvana, Richard J Kuhn, Michael G Rossmann
Zika virus (ZIKV) is an enveloped, icosahedral flavivirus that has structural and functional similarities to other human flavivirus pathogens such as dengue (DENV), West Nile (WNV) and Japanese encephalitis (JEV) viruses. ZIKV infections have been linked to fetal microcephaly and the paralytic Guillain-Barré syndrome. This review provides a comparative structural analysis of the assembly, maturation and host-cell entry of ZIKV with other flaviviruses, especially DENV. We also discuss the mechanisms of neutralization by antibodies...
January 2018: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/29318796/recurrent-guillain-barr%C3%A3-syndrome-following-urinary-tract-infection-by-escherichia-coli
#4
Yoon Sik Jo, Jin Yong Choi, Hong Chung, Yuseok Kim, Sang Jun Na
Recurrent Guillain-Barré syndrome (GBS) is a rare, immune-mediated disease of the peripheral nervous system. It has been reported to occur at intervals ranging from four months to 10 years; published case studies suggest that 1%-6% of patients who have had GBS will experience recurrent attacks. The most commonly identified infections coinciding with GBS are Campylobacter jejuni, Haemophilus influenzae, Mycoplasma pneumonia, and cytomegalovirus, while an antecedent infection with Escherichia coli is very uncommon...
January 22, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29300166/a-systematic-review-of-zika-virus-hurdles-toward-vaccine-development-and-the-way-forward
#5
Azizul Haque, Faruk Berat Akçeşme, Anudeep B Pant
The Zika virus (ZIKV) epidemic has recently emerged as public health threat due to its teratogenic nature and association with the serious neurological condition Guillain-Barré syndrome (GBS). To date, no approved antiviral therapeutics or vaccines are available to confront ZIKV. In order to develop effective anti-ZIKV vaccines, improved animal models and a better understanding of immunological correlates of protection against ZIKV are required. In this paper, we discuss the recent progress in developing vaccines against ZIKV and the hurdles to overcome in making efficacious anti-Zika vaccines...
January 4, 2018: Antiviral Therapy
https://www.readbyqxmd.com/read/29299896/infective-endocarditis-presenting-as-endogenous-endophthalmitis-secondary-to-streptococcus-agalactiae-in-a-healthy-adult-case-reports-and-literature-review
#6
Yu Ra Sim, Ye Jin Lee, Seung Woon Park, Sang Hyun Kim, Ju Hee Choi, Jung Yoon Choi, Min Ja Kim, Jang Wook Sohn, Jaemoon Ahn, Young Kyung Yoon
Endogenous endophthalmitis secondary to group B Streptococcus (GBS) is extremely rare, particularly in healthy adults. However, the visual prognosis is poor. We report the first South Korean case of GBS infective endocarditis presenting as endogenous endophthalmitis and skin and soft tissue infection. Cultures of blood, vitreous humor, and pus from skin aspirates yielded a penicillin-susceptible serotype V strain of Streptococcus agalactiae. After 6 weeks, the patient completely recovered from GBS infective endocarditis...
December 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/29276699/zika-virus-an-emerging-global-health-threat
#7
REVIEW
Rahul Mittal, Desiree Nguyen, Luca H Debs, Amit P Patel, George Liu, Vasanti M Jhaveri, Sae-In S Kay, Jeenu Mittal, Emmalee S Bandstra, Ramzi T Younis, Prem Chapagain, Dushyantha T Jayaweera, Xue Zhong Liu
Zika virus (ZIKV) is an emerging healthcare threat. The presence of the mosquito Aedes species across South and Central America in combination with complementary climates have incited an epidemic of locally transmitted cases of ZIKV infection in Brazil. As one of the most significant current public health concerns in the Americas, ZIKV epidemic has been a cause of alarm due to its known and unknown complications. At this point, there has been a clear association between ZIKV infection and severe clinical manifestations in both adults and neonates, including but not limited to neurological deficits such as Guillain-Barré syndrome (GBS) and microcephaly, respectively...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29190868/-epidemiology-and-human-rights-zika-virus-outlook-and-reproductive-rights-in-latin-america
#8
Manuel G Chávez-Ángeles, Ericay Berenice Martínez-Ramos, Olga López-Hernández
With this article we review the current Zika virus (ZIKV) epidemic. We also look back over the last scientific evidence relating ZIKV to microcephaly and Guillain-Barré syndrome. Finally, we also address the challenges in terms of reproductive rights in Latin America.
November 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29189553/guillain-barr%C3%A3-syndrome-triggered-by-immune-checkpoint-inhibitors-a-case-report-and-literature-review
#9
Songkit Supakornnumporn, Bashar Katirji
Immune checkpoint inhibitors, used as immunotherapy in the treatment of melanoma and refractory cancer, may trigger autoimmune disorders. We describe a case of Guillain-Barré syndrome (GBS) after the treatment with ipilimumab and nivolumab and review 4 other reported cases. We confirmed the diagnosis of GBS by electrodiagnostic and cerebrospinal fluid studies. Electrodiagnostic results showed findings consistent with acquired demyelinating polyneuropathy and cerebrospinal fluid showed albuminocytologic dissociation...
December 2017: Journal of Clinical Neuromuscular Disease
https://www.readbyqxmd.com/read/29181810/imaging-findings-in-congenital-zika-virus-infection-syndrome-an-update
#10
Andrea Silveira de Souza, Patrícia Soares de Oliveira-Szjenfeld, Adriana Suely de Oliveira Melo, Luis Alberto Moreira de Souza, Alba Gean Medeiros Batista, Fernanda Tovar-Moll
BACKGROUND: Zika virus (ZIKV) is a neurotropic and neurotoxic RNA Flavivirus prompt to cause severe fetal brain dysmorphisms during pregnancy, a period of rapid and critical central nervous system development. A wide range of clinico-radiological findings of congenital ZIKV infections were reported in the literature, such as microcephaly, overlapping sutures, cortical migrational and corpus callosum abnormalities, intracranial calcifications, ventriculomegaly, brain stem and cerebellar malformations, spinal cord involvement, and joint contractures...
November 27, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29164611/serial-electrophysiology-in-guillain-barr%C3%A3-syndrome-a-retrospective-cohort-and-case-by-case-multicentre-analysis
#11
J Ibrahim, A-M Grapperon, F Manfredonia, P Y van den Bergh, S Attarian, Y A Rajabally
OBJECTIVES: To assess the usefulness of serial electrophysiology in Guillain-Barré syndrome (GBS) in a multicenter setting and the reasons for change in electrodiagnostic subtypes with serial studies. METHODS: We retrospectively analysed serial electrophysiology of 51 patients with GBS from 4 European centres. Proportions of subtypes were determined at each timing. Individual case analyses were also performed where diagnostic changes occurred with either criteria, to ascertain if changes were due to disease progression or criteria inadequacy...
November 21, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29153605/associations-between-tumor-necrosis-factor-%C3%AE-gene-polymorphisms-and-the-risk-of-guillain-barr%C3%A3-syndrome-and-its-subtypes-a-systematic-review-and-meta-analysis
#12
Ju Liu, Zhiyun Lian, Hongxi Chen, Ziyan Shi, Huiru Feng, Qin Du, Qin Zhang, Hongyu Zhou
This meta-analysis aimed to assess the relationship between tumor necrosis factor-α (TNF-α) polymorphisms and Guillain-Barré syndrome (GBS) or its subtypes of acute inflammatory demyelinating polyneuropathy (AIDP), acute motor axonal neuropathy (AMAN), and acute motor-sensory axonal neuropathy (AMSAN). A total of six studies with 1013 cases and 1029 controls were included. Our pooled data indicated that TNF-α 308G/A polymorphism was significantly associated with GBS, AMAN, and AMSAN but not with AIDP; TNF-α 857C/T polymorphism was significantly associated with AMAN but not with GBS or AIDP...
December 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29138078/is-there-an-indication-of-intraoperative-mri-in-subtotal-resection-of-glioblastoma-a-multicenter-retrospective-comparative-analysis
#13
Jan Coburger, Javier Segovia von Riehm, Oliver Ganslandt, Christian Rainer Wirtz, Mirjam Renovanz
INTRODUCTION: Surgery in patients with highly eloquent glioblastoma (GB) remains challenging. OBJECTIVE: To evaluate influence of use of iMRI on extent of resection (EoR), clinical outcome and survival in GB-patients with preoperatively intended subtotal resection (STR). METHODS: We performed a retrospective assessment in 3 neurosurgical centers(2008-2013). All patients with primary GB, unilocular growth, and adjuvant radiochemotherapy in whom a STR was intended were included...
November 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29135369/t-cell-immunity-to-zika-and-dengue-viral-infections
#14
Jinsheng Wen, Sujan Shresta
The 2015-2016 Zika virus (ZIKV) outbreak in the Americas has brought this relatively unknown flavivirus into the spotlight as the etiologic agent of congenital Zika syndrome in newborns and, potentially, of Guillain-Barré syndrome in adults. ZIKV shares a high degree of amino acid sequence homology with the closely related flavivirus Dengue virus (DENV). Due to the paucity of research investigating T cell-mediated immune responses to ZIKV, the precise roles of T cells in protection against and pathogenesis of ZIKV infection are unclear...
November 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/29129472/effectiveness-of-intrapartum-antibiotic-prophylaxis-for-early-onset-group-b-streptococcal-infection-an-integrative-review
#15
REVIEW
Kathryn Braye, John Ferguson, Deborah Davis, Christine Catling, Amy Monk, Maralyn Foureur
BACKGROUND: In some countries, up to 30% of women are exposed to intrapartum antibiotic prophylaxis for prevention of early-onset group B Streptococcal infection. Intrapartum antibiotic prophylaxis aims to reduce the risk of neonatal morbidity and mortality from this infection. The intervention may adversely affect non-pathogenic bacteria which are passed to the newborn during birth and are considered important in optimising health. Since many women are offered intrapartum antibiotic prophylaxis, effectiveness and implications of this intervention need to be established...
November 9, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/29117331/neurodevelopmental-impairment-in-children-after-group-b-streptococcal-disease-worldwide-systematic-review-and-meta-analyses
#16
Maya Kohli-Lynch, Neal J Russell, Anna C Seale, Ziyaad Dangor, Cally J Tann, Carol J Baker, Linda Bartlett, Clare Cutland, Michael G Gravett, Paul T Heath, Margaret Ip, Kirsty Le Doare, Shabir A Madhi, Craig E Rubens, Samir K Saha, Stephanie Schrag, Ajoke Sobanjo-Ter Meulen, Johan Vekemans, Catherine O'Sullivan, Firdose Nakwa, Hechmi Ben Hamouda, Habib Soua, Kyriaki Giorgakoudi, Shamez Ladhani, Theresa Lamagni, Hilary Rattue, Caroline Trotter, Joy E Lawn
Background: Survivors of infant group B streptococcal (GBS) disease are at risk of neurodevelopmental impairment (NDI), a burden not previously systematically quantified. This is the 10th of 11 articles estimating the burden of GBS disease. Here we aimed to estimate NDI in survivors of infant GBS disease. Methods: We conducted systematic literature reviews (PubMed/Medline, Embase, Latin American and Caribbean Health Sciences Literature [LILACS], World Health Organization Library Information System [WHOLIS], and Scopus) and sought unpublished data on the risk of NDI after invasive GBS disease in infants <90 days of age...
November 6, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29117330/neonatal-encephalopathy-with-group-b-streptococcal-disease-worldwide-systematic-review-investigator-group-datasets-and-meta-analysis
#17
Cally J Tann, Kathryn A Martinello, Samantha Sadoo, Joy E Lawn, Anna C Seale, Maira Vega-Poblete, Neal J Russell, Carol J Baker, Linda Bartlett, Clare Cutland, Michael G Gravett, Margaret Ip, Kirsty Le Doare, Shabir A Madhi, Craig E Rubens, Samir K Saha, Stephanie Schrag, Ajoke Sobanjo-Ter Meulen, Johan Vekemans, Paul T Heath
Background: Neonatal encephalopathy (NE) is a leading cause of child mortality and longer-term impairment. Infection can sensitize the newborn brain to injury; however, the role of group B streptococcal (GBS) disease has not been reviewed. This paper is the ninth in an 11-article series estimating the burden of GBS disease; here we aim to assess the proportion of GBS in NE cases. Methods: We conducted systematic literature reviews (PubMed/Medline, Embase, Latin American and Caribbean Health Sciences Literature [LILACS], World Health Organization Library Information System [WHOLIS], and Scopus) and sought unpublished data from investigator groups reporting GBS-associated NE...
November 6, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29117329/preterm-birth-associated-with-group-b-streptococcus-maternal-colonization-worldwide-systematic-review-and-meta-analyses
#18
Fiorella Bianchi-Jassir, Anna C Seale, Maya Kohli-Lynch, Joy E Lawn, Carol J Baker, Linda Bartlett, Clare Cutland, Michael G Gravett, Paul T Heath, Margaret Ip, Kirsty Le Doare, Shabir A Madhi, Samir K Saha, Stephanie Schrag, Ajoke Sobanjo-Ter Meulen, Johan Vekemans, Craig E Rubens
Background: Preterm birth complications are the leading cause of deaths among children <5 years of age. Studies have suggested that group B Streptococcus (GBS) maternal rectovaginal colonization during pregnancy may be a risk factor for preterm delivery. This article is the fifth of 11 in a series. We aimed to assess the association between GBS maternal colonization and preterm birth in order to inform estimates of the burden of GBS. Methods: We conducted systematic literature reviews (PubMed/Medline, Embase, Latin American and Caribbean Health Sciences Literature [LILACS], World Health Organization Library Information System [WHOLIS], and Scopus) and sought unpublished data from investigator groups on the association of preterm birth (<37 weeks' gestation) and maternal GBS colonization (GBS isolation from vaginal, cervical, and/or rectal swabs; with separate subanalysis on GBS bacteriuria)...
November 6, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29117328/maternal-disease-with-group-b-streptococcus-and-serotype-distribution-worldwide-systematic-review-and-meta-analyses
#19
Jennifer Hall, Nadine Hack Adams, Linda Bartlett, Anna C Seale, Theresa Lamagni, Fiorella Bianchi-Jassir, Joy E Lawn, Carol J Baker, Clare Cutland, Paul T Heath, Margaret Ip, Kirsty Le Doare, Shabir A Madhi, Craig E Rubens, Samir K Saha, Stephanie Schrag, Ajoke Sobanjo-Ter Meulen, Johan Vekemans, Michael G Gravett
Background: Infections such as group B Streptococcus (GBS) are an important cause of maternal sepsis, yet limited data on epidemiology exist. This article, the third of 11, estimates the incidence of maternal GBS disease worldwide. Methods: We conducted systematic literature reviews (PubMed/Medline, Embase, Latin American and Caribbean Health Sciences Literature [LILACS], World Health Organization Library Information System [WHOLIS], and Scopus) and sought unpublished data on invasive GBS disease in women pregnant or within 42 days postpartum...
November 6, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29117327/maternal-colonization-with-group-b-streptococcus-and-serotype-distribution-worldwide-systematic-review-and-meta-analyses
#20
Neal J Russell, Anna C Seale, Megan O'Driscoll, Catherine O'Sullivan, Fiorella Bianchi-Jassir, Juan Gonzalez-Guarin, Joy E Lawn, Carol J Baker, Linda Bartlett, Clare Cutland, Michael G Gravett, Paul T Heath, Kirsty Le Doare, Shabir A Madhi, Craig E Rubens, Stephanie Schrag, Ajoke Sobanjo-Ter Meulen, Johan Vekemans, Samir K Saha, Margaret Ip
Background: Maternal rectovaginal colonization with group B Streptococcus (GBS) is the most common pathway for GBS disease in mother, fetus, and newborn. This article, the second in a series estimating the burden of GBS, aims to determine the prevalence and serotype distribution of GBS colonizing pregnant women worldwide. Methods: We conducted systematic literature reviews (PubMed/Medline, Embase, Latin American and Caribbean Health Sciences Literature [LILACS], World Health Organization Library Information System [WHOLIS], and Scopus), organized Chinese language searches, and sought unpublished data from investigator groups...
November 6, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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