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Depressive Disorders

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https://www.readbyqxmd.com/read/29913543/recommendations-for-the-use-of-testosterone-in-male-transgender
#1
Laura Bregieiro Fernandes Costa, Ana Carolina Japur de Sá Rosa-E-Silva, Sebastião Freitas de Medeiros, Andrea Prestes Nacul, Bruno Ramalho de Carvalho, Cristina Laguna Benetti-Pinto, Daniela Angerame Yela, Gustavo Arantes Rosa Maciel, José Maria Soares Júnior, Técia Maria de Oliveira Maranhão
Gender incongruence is defined as a condition in which an individual self-identifies and desires to have physical characteristics and social roles that connote the opposite biological sex. Gender dysphoria is when an individual displays the anxiety and/or depression disorders that result from the incongruity between the gender identity and the biological sex. The gender affirmation process must be performed by a multidisciplinary team. The main goal of the hormone treatment is to start the development of male physical characteristics by means of testosterone administration that may be offered to transgender men who are 18 years old or over...
May 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29913492/review-in-major-depressive-disorder-antidepressant-drugs-improve-short-term-response-compared-with-placebo
#2
Brian Budenholzer
No abstract text is available yet for this article.
June 19, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29913341/impulse-control-disorders-in-parkinson-s-disease-patients-with-rls-a-cross-sectional-study
#3
Ana Marques, Michela Figorilli, Bruno Pereira, Philippe Derost, Berengere Debilly, Patricia Beudin, Tiphaine Vidal, Franck Durif, Maria Livia Fantini
BACKGROUND: Although dopamine replacement therapy is the main risk factor for the occurrence of Impulse Control Disorders (ICDs) in Parkinson's disease (PD), non-pharmacological risk factors for have also been identified in that population and sleep disorders could be part of them. Our objective is to determine whether Restless Legs Syndrome (RLS), that has been associated with more impulsive choices in general population regardless of dopaminergic therapy, could be associated with a specific psycho-behavioral profile and ICDs in PD...
March 1, 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29913130/effect-of-5-httlpr-on-current-source-density-connectivity-and-topological-properties-of-resting-state-eeg-networks
#4
Ekaterina A Proshina, Alexander N Savostyanov, Andrey V Bocharov, Gennady G Knyazev
The S allele of serotonin transporter gene (5-HTTLPR) has been found to increase the risk of depression and other mental health problems, but some evidence suggests that S-allele carriers outperform subjects carrying the long allele in an array of cognitive tasks. Evidence linking this polymorphism with individual variation in electrophysiological properties of resting state brain networks is very limited. This study investigated the effect of 5-HTTLPR polymorphism on EEG current source density, connectivity, and topological properties of resting state networks...
June 15, 2018: Brain Research
https://www.readbyqxmd.com/read/29913083/risk-factors-for-recurrent-neurotrauma-a-population-based-study-in-southeastern-michigan
#5
R David Hayward, Mary M Fessler, Joseph Buck, Richard D Fessler
INTRODUCTION: Studies have shown an increased risk of traumatic brain injury (TBI) for individuals who suffer an initial TBI. The current study hypothesized that individuals with recurrent neurotrauma would originate from populations considered 'vulnerable', i.e. low income and/or with psychiatric comorbidities. METHODS: Data from the Michigan State Inpatient Database from 2006 to 2014 for the Detroit metropolitan area enlisted a study population of 50 744 patients with neurotrauma...
June 18, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29913077/higher-exosomal-tau-amyloid-beta-42-and-il-10-are-associated-with-mild-tbis-and-chronic-symptoms-in-military-personnel
#6
Jessica Gill, Maja Mustapic, Ramon Diaz-Arrastia, Rael Lange, Seema Gulyani, Tom Diehl, Vida Motamedi, Nicole Osier, Robert A Stern, Dimitrios Kapogiannis
OBJECTIVE: Identify biomarkers in peripheral blood that relate to chronic post-concussive and behavioural symptoms following traumatic brain injuries (TBIs) to ultimately improve clinical management. RESEARCH DESIGN: We compared military personnel with mild TBIs (mTBIs) (n = 42) to those without TBIs (n = 22) in concentrations of tau, amyloid-beta (Aβ42) and cytokines (tumour necrosis factor alpha (TNFα, interleukin (IL)-6 and -10) in neuronal-derived exosomes from the peripheral blood...
June 18, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29912861/birth-month-and-course-of-recurrent-depressive-disorders-in-a-polish-population
#7
Monika Talarowska, Katarzyna Bliźniewska, Katarzyna Wargacka, Piotr Gałecki
BACKGROUND The aim of this study was to determine whether the specific season of the year during which the first trimester of pregnancy takes place is significantly associated with the course (intensification and frequency of occurrence) of an episode of recurrent depressive disorder in adult life. MATERIAL AND METHODS We enrolled 184 patients treated for recurrent depressive disorders. RESULTS An analysis of the results obtained indicates that the greatest number of people suffering from a major depressive episode were born in the spring and summer (from April to September), meaning that the first trimester of pregnancy occurred between October and March...
June 18, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29912848/identify-abnormalities-in-resting-state-brain-function-between-first-episode-drug-naive-major-depressive-disorder-and-remitted-individuals-a-3-year-retrospective-study
#8
Chunxia Yang, Aixia Zhang, Aixiang Jia, Jack X Ma, Ning Sun, Yanfang Wang, Xinrong Li, Zhifen Liu, Sha Liu, Yong Xu, Kerang Zhang
This study aims to identify and characterize neurobiological markers for major depressive disorder (MDD) from resting-state brain functional MRI. We examined the abnormality in the regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) in first-episode, drug-naive major depressive disorder (fMDD), and remitted major depressive disorder (rMDD) and correlated these fluctuations with clinical markers of MDD. We conducted a retrospective study and reviewed the medical records of 43 patients with fMDD...
June 15, 2018: Neuroreport
https://www.readbyqxmd.com/read/29912786/a-12-month-open-label-extension-study-of-the-safety-and-tolerability-of-lisdexamfetamine-dimesylate-for-major-depressive-disorder-in-adults
#9
Cynthia Richards, Dan V Iosifescu, Rajnish Mago, Elias Sarkis, Brooke Geibel, Matthew Dauphin, Roger S McIntyre, Richard Weisler, Olga Brawman-Mintzer, Joan Gu, Manisha Madhoo
PURPOSE/BACKGROUND: Psychostimulant augmentation is considered a potential treatment strategy for individuals with major depressive disorder who do not adequately respond to antidepressant monotherapy. The primary objective of this 12-month open-label extension study was to evaluate the safety and tolerability of lisdexamfetamine dimesylate (LDX) as augmentation therapy to an antidepressant in adults with major depressive disorder. METHODS/PROCEDURES: Eligible adults who completed 1 of 3 short-term antecedent LDX augmentation of antidepressant monotherapy studies were treated with dose-optimized LDX (20-70 mg) for up to 52 weeks while continuing on the index antidepressant (escitalopram, sertraline, venlafaxine extended-release, or duloxetine) assigned during the antecedent short-term studies...
June 16, 2018: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29912465/prevalence-and-pattern-of-psychosocial-disorders-among-caregivers-of-hiv-infected-children-in-enugu-south-eastern-nigeria
#10
I F Ogbonna, I J Emodi, A N Ikefuna, N C Ojinnaka
Background: Nigeria has the highest burden of paediatric HIV in the world. HIV infection may result in significant life stressors, on both the infected children and their caregivers. Methods: This included a hospital-based cross-sectional and comparative study. Subjects and controls who met the inclusion criteria were enrolled consecutively. Their socio-demographic variables were obtained and GHQ-28 was used to assess their psychosocial status. Results: A total of 154 caregivers of HIV-infected children (subjects) and 154 caregivers of HIV-negative children (controls) were enrolled into this study...
April 17, 2018: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29912442/eqtls-weighted-genetic-correlation-analysis-detected-brain-region-differences-in-genetic-correlations-for-complex-psychiatric-disorders
#11
Yan Wen, Feng Zhang, Xiancang Ma, Qianrui Fan, Wenyu Wang, Jiawen Xu, Feng Zhu, Jingcan Hao, Awen He, Li Liu, Xiao Liang, Yanan Du, Ping Li, Cuiyan Wu, Sen Wang, Xi Wang, Yujie Ning, Xiong Guo
Background: Psychiatric disorders are usually caused by the dysfunction of various brain regions. Incorporating the genetic information of brain regions into correlation analysis can provide novel clues for pathogenetic and therapeutic studies of psychiatric disorders. Methods: The latest genome-wide association study (GWAS) summary data of schizophrenia (SCZ), bipolar disorder (BIP), autism spectrum disorder (AUT), major depression disorder (MDD), and attention-deficit/hyperactivity disorder (ADHD) were obtained from the Psychiatric GWAS Consortium (PGC)...
June 15, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29912418/moral-injury-religiosity-and-suicide-risk-in-u-s-veterans-and-active-duty-military-with-ptsd-symptoms
#12
Donna Ames, Zachary Erickson, Nagy A Youssef, Irina Arnold, Chaplain Sam Adamson, Alexander C Sones, Justin Yin, Kerry Haynes, Fred Volk, Ellen J Teng, John P Oliver, Harold G Koenig
Introduction: There is growing evidence that moral injury (MI) is related to greater suicide risk among Veterans and Active Duty Military (V/ADM). This study examines the relationship between MI and suicide risk and the moderating effect of religiosity on this relationship in V/ADM with post-traumatic stress disorder (PTSD) symptoms. Materials and Methods: This was a cross-sectional multi-site study involving 570 V/ADM from across the USA. Inclusion criteria were having served in a combat theater and the presence of PTSD symptoms...
June 15, 2018: Military Medicine
https://www.readbyqxmd.com/read/29912316/constitutive-inactivation-of-the-prrt2-gene-alters-short-term-synaptic-plasticity-and-promotes-network-hyperexcitability-in-hippocampal-neurons
#13
Pierluigi Valente, Alessandra Romei, Manuela Fadda, Bruno Sterlini, Davide Lonardoni, Nicola Forte, Floriana Fruscione, Enrico Castroflorio, Caterina Michetti, Giorgia Giansante, Flavia Valtorta, Jin-Wu Tsai, Federico Zara, Thierry Nieus, Anna Corradi, Anna Fassio, Pietro Baldelli, Fabio Benfenati
Mutations in PRoline-Rich Transmembrane protein 2 (PRRT2) underlie a group of paroxysmal disorders including epilepsy, kinesigenic dyskinesia and migraine. Most of the mutations lead to impaired PRRT2 expression and/or function, emphasizing the pathogenic role of the PRRT2 deficiency. In this work, we investigated the phenotype of primary hippocampal neurons obtained from mouse embryos in which the PRRT2 gene was constitutively inactivated. Although PRRT2 is expressed by both excitatory and inhibitory neurons, its deletion decreases the number of excitatory synapses without significantly affecting the number of inhibitory synapses or the nerve terminal ultrastructure...
April 18, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29912203/an-invasive-method-for-the-activation-of-the-mouse-dentate-gyrus-by-high-frequency-stimulation
#14
Zhe Zhao, Haitao Wu
Electrical high-frequency stimulation (HFS), using implanted electrodes targeting various brain regions, has been proven as an effective treatment for various neurological and psychiatric disorders. HFS in the deep region of the brain, also named deep-brain stimulation (DBS), is becoming increasingly important in clinical trials. Recent progress in the field of high-frequency DBS (HF-DBS) surgery has begun to spread the possibility of utilizing this invasive technique to other situations, such as treatment for major depression disorder (MDD), obsessive-compulsive disorder (OCD), and so on...
June 2, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29911956/social-support-violence-exposure-and-mental-health-among-young-south-african-adolescents
#15
Annette Humm, Debra Kaminer, Anneli Hardy
OBJECTIVE: Cumulative violence exposure has been associated with both internalising and externalising difficulties in youth. Therefore, it is important to identify protective factors that may ameliorate both exposure to and the impact of cumulative violence. This study aimed to identify sources of perceived social support amongst early adolescents in a low-income, high-violence community in South Africa, and to examine the association of perceived support with exposure to violence and with the severity of depression, aggression and conduct disorder symptoms...
May 2018: Journal of Child and Adolescent Mental Health
https://www.readbyqxmd.com/read/29911751/exercise-dehydroepiandrosterone-dhea-and-mood-change-a-rationale-for-the-runners-high
#16
Yosef Sonnenblick, Michal Taler, Yaacov G Bachner, Rael D Strous
BACKGROUND: Although exercise has been shown to improve mood and well-being, the precise mechanism remains unknown. Neurosteroids are important neuroactive molecules with demonstrated involvement in several neurophysiological and disease processes. Previous research has noted neurosteroid changes in dehydroepiandrosterone (DHEA) levels following exercise. OBJECTIVES: To determine whether changes in DHEA levels are associated with mood improvement after exercise and whether there are any differences in the effects on younger and older individuals...
June 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29911653/cognitive-behaviour-therapy-in-women-with-fibromyalgia-a-randomized-clinical-trial
#17
Bo Karlsson, Gunilla Burell, Ulla-Maria Anderberg, Kurt Svärdsudd
Background and aims Stress has been pointed out as an important influential factor in the development and maintaining of the fibromyalgia syndrome (FMS) . Since stress may worsen the pain experience, the development of individual strategies for coping with stress is essential to reduce the impact of FMS on daily life. The aim of the study was to investigate whether a group based stress management cognitive behaviour therapy (CBT) programme could influence self-reported stress, wellbeing and life control, as well as self-reported pain behaviour in female FMS patients...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29911642/the-swedish-version-of-the-insomnia-severity-index-factor-structure-analysis-and-psychometric-properties-in-chronic-pain-patients
#18
Elena Dragioti, Tobias Wiklund, Peter Alföldi, Björn Gerdle
Objective Insomnia is the most commonly diagnosed comorbidity disorder among patients with chronic pain. This circumstance requests brief and valid instruments for screening insomnia in epidemiological studies. The main object of this study was to assess the psychometric properties and factor structure of the Swedish version of the Insomnia Severity Index (ISI). The ISI is a short instrument designed to measure clinical insomnia and one of the most common used scales both in clinical and research practice. However there is no study in Sweden that guarantees neither its factor structure nor its feasibility in chronic pain patients...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29911607/practitioners-perspective-on-pain-disabilities-in-ghanaian-women-a-qualitative-study
#19
D Ayim-Aboagye, T Gordh
Aims Women show higher frequency of most painful disorders. This is usually explained that endogenous pain modulation pathways, which affect incoming nociceptive signals, act differently in women and men, but psycho-social factors are likelytoinfluence as well. Ghanaian women suffer different disabilities that may lead to severe pain. The hard climatic conditions and the hard physical toil in work exert untold injuries. How do women in Ghana cope with painful disorders, and do they show certain behavioural pattern during diagnosis and treatments? Methods The study used in-depth interviews with health care providers to accomplish its aim...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29911521/integrated-perinatal-mental-health-care-a-national-model-of-perinatal-primary-care-in-vulnerable-populations
#20
Kimberly C Lomonaco-Haycraft, Jennifer Hyer, Britney Tibbits, Jennifer Grote, Kelly Stainback-Tracy, Claire Ulrickson, Alison Lieberman, Lies van Bekkum, M Camille Hoffman
IntroductionPerinatal mood and anxiety disorders (PMADs) are the most common complication of pregnancy and have been found to have long-term implications for both mother and child. In vulnerable patient populations such as those served at Denver Health, a federally qualified health center the prevalence of PMADs is nearly double the nationally reported rate of 15-20%. Nearly 17% of women will be diagnosed with major depression at some point in their lives and those numbers are twice as high in women who live in poverty...
June 18, 2018: Primary Health Care Research & Development
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