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https://www.readbyqxmd.com/read/29471329/effects-of-varenicline-depressive-symptoms-and-region-of-enrollment-on-smoking-cessation-in-depressed-smokers
#1
Neal Doran, Sarah Dubrava, Robert M Anthenelli
Introduction: Despite effective treatments, relapse to smoking remains a vexing global health problem. One predictor of relapse is depressive symptoms. Medications such as varenicline reduce withdrawal-related symptoms of depression, reducing relapse. This study examined whether varenicline moderated the effect of depressive symptoms on relapse, and whether this varied by region of enrollment. Methods: Adult smokers (n=525; 37% male) with past or current, stable major depressive disorder recruited from US (n=255), and European (n=270) sites participated in a randomized, double-blind cessation treatment trial including 12 weeks of varenicline or placebo, with 40-week non-treatment follow-up...
February 17, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29471081/schematic-beliefs-and-problem-solving-performance-predict-depression-in-people-experiencing-persecutory-delusions
#2
Natasha Vorontsova, Philippa Garety, Daniel Freeman
Depression occurring alongside psychosis is an important treatment target, both in its own right and as a potential maintenance factor for positive psychotic symptoms. The present paper reports a prospective longitudinal analysis of depression and its predictors over six months in a group of 60 participants experiencing persecutory delusions. We hypothesised that negative schematic beliefs about the self and problem solving difficulties would predict the persistence of depression over time. The results showed, as hypothesised, that more negative schematic beliefs about the self and poorer problem solving predicted higher depression scores six months later, beyond what could be predicted by baseline depression scores...
February 13, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29470596/mental-health-burden-in-a-national-sample-of-american-indian-and-alaska-native-adults-differences-between-multiple-race-and-single-race-subgroups
#3
Nancy L Asdigian, Ursula Running Bear, Janette Beals, Spero M Manson, Carol E Kaufman
PURPOSE: Research on American Indian and Alaska Native (AIAN) mental health disparities is based largely on either tribal populations or national samples of adults that do not account for multiracial AIANs, even though over 40% of AIANs identify with multiple racial groups. The present investigation extends this research by assessing mental health status in a national sample of multiracial AIAN adults relative to adults who identify exclusively as either AIAN or White. METHODS: 2012 BRFSS data were used to conduct multinomial logistic regression analyses comparing mental health outcomes among respondents who identified as either AIAN and one or more other races (AIAN-MR), AIAN-Single Race (AIAN-SR), or White-SR...
February 22, 2018: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/29470512/association-between-hiv-status-and-depressive-symptoms-among-children-and-adolescents-in-the-southern-highlands-zone-tanzania-a-case-control-study
#4
Abraham Lwidiko, Stephen Matthew Kibusi, Azan Nyundo, Bonaventura C T Mpondo
BACKGROUND: Children and adolescents continue to have HIV/AIDS in southern Saharan Africa. Scaling up of HIV services has significantly improved access to ARV and consequently improved on morbidity and mortality related to HIV/AIDS including opportunistic infection. Despite the above efforts, non-communicable conditions including mental disorders such as depression have been observed to contribute to the burden of disabilities about which little is documented. This study, therefore, aimed to determine the magnitude of depressive symptoms and the associated factors among HIV-infected children and adolescents...
2018: PloS One
https://www.readbyqxmd.com/read/29470277/does-duration-of-pain-at-baseline-influence-clinical-outcomes-of-low-back-pain-patients-managed-on-an-evidence-based-pathway
#5
Mary-Anne Jess, Ryan Cormac, Sharon Hamilton, Shaun Wellburn, Greg Atkinson, Charles Greenough, Andrew Coxon, Diarmaid Ferguson, Francis Fatoye, John Dickson, Andrea Jones, Denis Martin
Supplemental Digital Content is available in the text STUDY DESIGN.: Longitudinal observational study. OBJECTIVE: To investigate the association between the duration of pain at baseline and the clinical outcomes of patients with low back pain (LBP) enrolled on the North East of England Regional Back Pain and Radicular Pain Pathway (NERBPP). SUMMARY OF BACKGROUND DATA: The NERBPP is a clinical pathway based upon NICE guidelines (2009) for LBP of <1-year duration...
February 21, 2018: Spine
https://www.readbyqxmd.com/read/29470185/psychological-factors-and-the-development-of-chronic-whiplash-associated-disorder-s-a-systematic-review
#6
Letitia Campbell, Ashley Smith, Leanne McGregor, Michele Sterling
OBJECTIVES: To assess which psychological factors are important in the development of chronic whiplash symptoms. METHODS: Searches were conducted across PubMed, CINAHL, Scopus and PsychINFO up until March 2017. Studies were included if they investigated psychological prognostic factors in association with recovery from a whiplash injury. Studies also had to be prospective, cohort, follow-up or observational studies, have a 6 month follow up and published in English...
February 21, 2018: Clinical Journal of Pain
https://www.readbyqxmd.com/read/29470096/the-psychometric-properties-sensitivity-and-specificity-of-the-geriatric-anxiety-inventory-hospital-anxiety-and-depression-scale-and-rating-anxiety-in-dementia-scale-in-aged-care-residents
#7
Alexandra S Creighton, Tanya E Davison, David W Kissane
OBJECTIVES: Limited research has been conducted into the identification of a valid and reliable screening measure for anxiety in aged care settings, despite it being one of the most common psychological conditions. This study aimed to determine an appropriate anxiety screening tool for aged care by comparing the reliability and validity of three commonly used measures and identifying specific cut-offs for the identification of generalized anxiety disorder (GAD). METHOD: One-hundred and eighty nursing home residents (M age = 85...
February 22, 2018: Aging & Mental Health
https://www.readbyqxmd.com/read/29469908/limited-jaw-movements-and-somatization-but-not-pain-may-play-a-role-in-salivary-flow-in-female-patients-with-temporomandibular-disorders
#8
Irena Mladenovic, Jelena Krunic, Nikola Stojanovic, Dusanka Markovic, Silvia Rdt de Siqueira
AIMS: To explore the unstimulated salivary flow rate and subjective feeling of oral dryness in young adult women with temporomandibular disorders (TMD) and their relation to the presence of chronic pain, depression, somatization, and limited mandibular mobility. METHODS: Unstimulated whole saliva flow rate and presence of oral dryness were determined in 45 women with TMD and 30 healthy controls. The Research Diagnostic Criteria for TMD (RDC/TMD) were used for assessment of TMD, chronic pain, depression, somatization, and mandibular mobility...
February 21, 2018: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/29469667/10-year-outcome-of-suicidal-behavior-in-borderline-personality-disorder
#9
Paul H Soloff, Laurel Chiappetta
Prospective predictors of suicide attempts were assessed in 118 subjects with borderline personality disorder (BPD) after 10 or more years of follow-up. Mean (SD) time to follow-up was 14.4 (4.7) years. Subjects were predominately female (78.8%), Caucasian (81.4%), and of lower socioeconomic status. Initial recruitment was evenly balanced between inpatient, outpatient, and non-patient (community) sources. In the 10-year interval, 55 subjects (46.6%) attempted suicide. Compared to baseline, suicidal ideation, number of attempts, and non-suicidal self-injury diminished markedly...
February 22, 2018: Journal of Personality Disorders
https://www.readbyqxmd.com/read/29469637/mental-illness-in-sweden-1896-1905-reflected-through-case-records-from-a-local-general-hospital
#10
Malin Appelquist, Louise Brådvik, Marie Åsberg
Mental illness in a hospital in a medium-sized town in Sweden was studied. Consecutive case records from 1896 to 1905, and also from 2011, were selected. In the historical sample, neurasthenia was the most common diagnosis, followed by affective disorders and alcohol abuse. ICD-10 diagnoses corresponded well with the historical diagnoses. Melancholia resembled modern criteria for depression. Mania, insania simplex and paranoia indicated more severe illness. Abuse was more common among men and hysteria among women...
February 1, 2018: History of Psychiatry
https://www.readbyqxmd.com/read/29469245/antipsychotic-prescriptions-among-adults-with-major-depressive-disorder-in-office-based-outpatient-settings-national-trends-from-2006-to-2015
#11
Taeho Greg Rhee, Somaia Mohamed, Robert A Rosenheck
OBJECTIVE: A recent moderately long-term study found an antipsychotic to be more effective than an antidepressant as the next-step treatment of unresponsive major depressive disorder (MDD). It is thus timely to examine recent trends in the pharmacoepidemiology of antipsychotic treatment of MDD. METHODS: Data from the 2006-2015 National Ambulatory Medical Care Survey, nationally representative samples of office-based outpatient visits in adults with MDD (ICD-9-CM codes 296...
February 13, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29468985/the-role-of-neurohypophyseal-hormones-vasopressin-and-oxytocin-in-neuropsychiatric-disorders
#12
Michele Iovino, Tullio Messana, Giovanni De Pergola, Emanuela Iovino, Franca Dicuonzo, Edoardo Guastamacchia, Vito Angelo Giagulli, Vincenzo Triggiani
Although the neurohypophyseal hormones vasopressin and oxytocin are mostly known for their role respectively in antiduresis the former and in labour, lactation and maternal behavior the latter, both might exert widespread influences either on emotion and cognition in healthy subjects, showing some gender-related differences. They interact one each other facilitating shifts between positive socially- oriented and defensive states. In fact, vasopressin amplifies the reactivity to stressors showing also beneficial effects on attention, verbal learning as well as memory, whereas oxytocin reduces the amplitude of the stress response, improves emotion processing, and can play a negative effect on memory and verbal learning in healthy individuals...
February 19, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29468978/comparing-effectiveness-of-a-combined-herbal-drug-based-on-echium-amoenum-with-citalopram-in-the-treatment-of-major-depressive-disorder
#13
Majid Anushiravani, Ali Akhondpour Manteghi, Ali Taghipur, Mahdi Eslami
BACKGROUND: According to new studies, only 60% of depressed patients respond to pharmaceutical treatment while suffering from their side effects. Natural products as adjuvant or alternative therapies should be examined to find safer and more effective ways to cope with depression. OBJECTIVE: Finding out the potential benefits of a combined herbal drug based on Echium amoenum compared with citalopram in the treatment of Major Depressive Disorder. DESIGN AND SETTING: In psychiatry clinics of Mashhad University of Medical Sciences, 50 patients who met the criteria for Major Depressive Disorder based on DSM-5 were studied in a parallel randomized controlled trial...
February 18, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29468884/borrowing-benefits-group-treatment-with-clinical-emotional-freedom-techniques-is-associated-with-simultaneous-reductions-in-posttraumatic-stress-disorder-anxiety-and-depression-symptoms
#14
Dawson Church, Dennis House
Clinical Emotional Freedom Techniques (EFT) is an evidence-based treatment for depression and anxiety. The current study sought to elucidate the relationship between posttraumatic stress disorder (PTSD), depression, and anxiety in a nonclinical population. The sample (N = 81) comprised participants at five 2-day EFT workshops. All groups used an EFT protocol called Borrowing Benefits, in which the group facilitator works with a single client while other participants self-apply EFT. Participants were assessed on 9 specific conditions as well as on the breadth (Positive Symptom Total [PST]) and depth (General Symptom Index [GSI]) of psychological distress...
January 2018: J Evid Based Integr Med
https://www.readbyqxmd.com/read/29468732/antidepressant-effects-of-dammarane-sapogenins-in-chronic-unpredictable-mild-stress-induced-depressive-mice
#15
Ning Jiang, Bei-Yue Zhang, Li-Ming Dong, Jing-Wei Lv, Cong Lu, Qiong Wang, Lin-Xi Fan, Hong-Xia Zhang, Rui-Le Pan, Xin-Min Liu
Depression is a common, dysthymic, and psychiatric disorder, resulting in enormous social and economic burden. Dammarane sapogenins (DS), an active fraction from oriental ginseng, has shown antidepressant-like effects in chronic restraint rats and sleep interruption-induced mice, and the present study aimed to further confirm the antidepressant effects of DS in a model of chronic unpredictable mild stress (CUMS) and to explore the underlying mechanism. Oral administration of DS (20, 40, and 80 mg/kg) markedly improved depressant-like behaviors, increasing the sucrose intake in the sucrose preference test and reducing the latency in the novelty-suppressed feeding test, and decreasing the immobility time in both the tail suspension and forced swimming tests, compared with the CUMS mice...
February 22, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29468523/gender-differential-in-social-and-economic-predictors-of-incident-major-depressive-disorder-in-the-ibadan-study-of-ageing
#16
Akin Ojagbemi, Toyin Bello, Oye Gureje
PURPOSE: Working on the hypothesis that the social and economic factors associated with onset of late-life depression operate differently for men and women, we investigated the impact of current social relationships and lifetime occupational attainment on incident major depressive disorder (MDD) assessed in three follow-up waves over a period of 5 years. METHODS: Participants were part of a household multistage probability sample of 2149 Nigerians who were aged 65 years and above...
February 21, 2018: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/29468357/sensitive-fathering-buffers-the-effects-of-chronic-maternal-depression-on-child-psychopathology
#17
Adam Vakrat, Yael Apter-Levy, Ruth Feldman
Maternal depression across the first years of life carries long-term negative consequences for children's well-being; yet, few studies focused on fathers as potential source of resilience in the context of chronic maternal depression. Utilizing an extreme-case design, a community birth cohort of married/cohabitating mothers (N = 1983) with no comorbid risk was repeatedly tested for maternal depression across the first year and again at 6 years, leading to two matched cohorts; 46 mothers with chronic depression and 103 non-depressed controls...
February 21, 2018: Child Psychiatry and Human Development
https://www.readbyqxmd.com/read/29467817/mental-health-literacy-what-do-nigerian-adolescents-know-about-depression
#18
Deborah O Aluh, Obinna C Anyachebelu, Chibueze Anosike, Ezinne L Anizoba
Background: Depression is a leading cause of disability and has been projected to become the 2nd most burdensome disease by the year 2020; depression has also been found to be the strongest single risk factor for attempted or completed suicides. Adolescent-onset mood disorders are frequently unrecognized or misdiagnosed and often go untreated. While there is a growing literature on the mental health literacy of adults, there has not been a parallel interest in the mental health literacy of young people in Nigeria...
2018: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/29467617/quantitative-proteomics-of-synaptosomal-fractions-in-a-rat-overexpressing-human-disc1-gene-indicates-profound-synaptic-dysregulation-in-the-dorsal-striatum
#19
Fernando J Sialana, An-Li Wang, Benedetta Fazari, Martina Kristofova, Roman Smidak, Svenja V Trossbach, Carsten Korth, Joseph P Huston, Maria A de Souza Silva, Gert Lubec
Disrupted-in-schizophrenia 1 (DISC1) is a key protein involved in behavioral processes and various mental disorders, including schizophrenia and major depression. A transgenic rat overexpressing non-mutant human DISC1, modeling aberrant proteostasis of the DISC1 protein, displays behavioral, biochemical and anatomical deficits consistent with aspects of mental disorders, including changes in the dorsal striatum, an anatomical region critical in the development of behavioral disorders. Herein, dorsal striatum of 10 transgenic DISC1 (tgDISC1) and 10 wild type (WT) littermate control rats was used for synaptosomal preparations and for performing liquid chromatography-tandem mass spectrometry (LC-MS)-based quantitative proteomics, using isobaric labeling (TMT10plex)...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29467572/prevalence-of-geriatric-syndromes-among-people-aged-65-years-and-older-at-four-community-clinics-in-moscow
#20
Olga N Tkacheva, Nadezda K Runikhina, Valentina S Ostapenko, Natalia V Sharashkina, Elen A Mkhitaryan, Julia S Onuchina, Sergei N Lysenkov, Nikolai N Yakhno, Yan Press
Background: Geriatric syndromes (GSs) are common in older adults and have a significant effect on their quality of life, disability, and use of health care resources. Few studies have assessed the prevalence of GSs in Russia. The aim of this study is to assess the prevalence of GSs among older adults living in the community in Moscow. Methods: A cross-sectional study was conducted in four community clinics in Moscow. A total of 1,220 patients completed a screening questionnaire, and 356 of them also underwent a comprehensive geriatric assessment (CGA)...
2018: Clinical Interventions in Aging
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