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https://www.readbyqxmd.com/read/27861905/attenuation-of-experimental-autoimmune-neuritis-with-locally-administered-lovastatin-encapsulating-plga-nanoparticles
#1
Kelly A Langert, Bruktawit Goshu, Evan B Stubbs
Acute inflammatory demyelinating polyneuropathy (AIDP) is an aggressive antibody- and T cell-mediated variant of Guillain-Barré Syndrome (GBS), a prominent and debilitating autoimmune disorder of the peripheral nervous system. Despite advancements in clinical management, treatment of patients with AIDP/GBS and its chronic variant CIDP remains palliative and relies on the use of non-specific immune-modulating therapies. Our laboratory has previously reported that therapeutic administration of statins safely attenuates the clinical severity of experimental autoimmune neuritis (EAN), a well-characterized animal model of AIDP/GBS, by restricting the migration of autoreactive leukocytes across peripheral nerve microvascular endoneurial endothelial cells (PNMECs) that form the blood-nerve barrier...
November 8, 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/27819421/early-electrodiagnostic-features-of-upper-extremity-sensory-nerves-can-differentiate-axonal-guillain-barr%C3%A3-syndrome-from-acute-inflammatory-demyelinating-polyneuropathy
#2
Yong Seo Koo, Ha Young Shin, Jong Kuk Kim, Tai Seung Nam, Kyong Jin Shin, Jong Seok Bae, Bum Chun Suh, Jeeyoung Oh, Byeol A Yoon, Byung Jo Kim
BACKGROUND AND PURPOSE: Serial nerve conduction studies (NCSs) are recommended for differentiating axonal and demyelinating Guillain-Barré syndrome (GBS), but this approach is not suitable for early diagnoses. This study was designed to identify possible NCS parameters for differentiating GBS subtypes. METHODS: We retrospectively reviewed the medical records of 70 patients with GBS who underwent NCS within 10 days of symptom onset. Patients with axonal GBS and acute inflammatory demyelinating polyneuropathy (AIDP) were selected based on clinical characteristics and serial NCSs...
October 2016: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/27761272/clinical-heterogeneity-of-guillain-barr%C3%A3-syndrome-in-the-emergency-department-impact-on-clinical-outcome
#3
Athanasios Papathanasiou, Ioannis Markakis
Guillain-Barré syndrome (GBS) is mainly classified into acute inflammatory demyelinating polyneuropathy (AIDP) and acute motor axonal neuropathy (AMAN). Although diagnosis of GBS requires progressive weakness and universal areflexia or hyporeflexia, cases of GBS with preserved or increased deep tendon reflexes (DTRs) have been increasingly recognized. We report three cases of GBS, presenting at a single unit in six months. Our first case presented with pure sensory symptoms. The second case had nonspecific generalized weakness, while the third presented with typical ascending weakness...
2016: Case Reports in Emergency Medicine
https://www.readbyqxmd.com/read/27756115/neurological-nuance-hodgkin-lymphoma-presenting-with-guillain-barr%C3%A3-syndrome
#4
Dustin Anderson, Grayson Beecher, Trevor A Steve, Ho Jen, Richard Camicioli, Douglas W Zochodne
INTRODUCTION: Hodgkin lymphoma (HL) is a common lymphoid malignancy rarely associated with Guillain-Barré syndrome (GBS). In most cases, GBS does not precede HL. METHODS: We describe a patient with acute inflammatory demyelinating polyneuropathy who fulfilled criteria for GBS that heralded undiagnosed HL. RESULTS: Cerebrospinal fluid (CSF) studies revealed albuminocytologic dissociation with significant protein elevation (250 mg/dl). The patient worsened during intravenous immunoglobulin (IVIg) therapy...
October 18, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27750406/optimizing-electrodiagnosis-for-guillain-barr%C3%A3-syndrome-clues-from-clinical-practice
#5
Yusuf A Rajabally, Fu Liong Hiew
INTRODUCTION: The most efficient method of performing electrophysiology for Guillain-Barré syndrome (GBS) is unknown. METHODS: We retrospectively analyzed electrophysiological data of 97 consecutive GBS patients from Birmingham, U.K. (2001-12) studied ≤3 weeks post-onset. RESULTS: The sensitivity of electrophysiology for each GBS subtype was dependent on the tested upper and lower limb nerves. In acute inflammatory demyelinating polyneuropathy (AIDP), abnormalities were predominant in the arms, whereas leg abnormalities predominated in axonal GBS...
October 17, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27706420/analysis-of-the-albumin-level-neutrophil-lymphocyte-ratio-and-platelet-lymphocyte-ratio-in-guillain-barr%C3%A3-syndrome
#6
Hasan Huseyin Ozdemir
The purpose of this study was to investigate the prognostic value of the pretreatment and post-treatment albumin level, neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR) in subtypes of Guillain-Barré syndrome (GBS). A retrospective analysis of 62 patients with GBS treated between 2011 and 2015 in Dicle University Hospital, Turkey, was carried out. The pretreatment and post-treatment albumin, NLR, and PLR were documented, together with acute inflammatory demyelinating polyradiculoneuropathy (AIDP), acute motor axonal neuropathy, motor sensory axonal neuropathy, and Hughes' scores...
September 2016: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/27666897/sle-neuropathy-anything-new
#7
Vikram A Londhey
SLE (systemic lupus erythematosus) is a multisystem autoimmune disorder of unknown aetiology which can present with myriad clinical presentation. The neurological manifestations of SLE consist of central nervous system (CNS) and peripheral nervous system manifestations (PNS). The CNS manifestations are aseptic meningitis, cerebrovascular accidents (stroke), demyelinating disorders, headache, involuntary movements like chorea, myelopathy, acute confusional states, cognitive dysfunction, mood disorder, seizures, psychosis and cranial nerve palsies...
December 2015: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27629711/resolvin-d1-programs-inflammation-resolution-by-increasing-tgf-%C3%AE-expression-induced-by-dying-cell-clearance-in-experimental-autoimmune-neuritis
#8
Bangwei Luo, Fuyu Han, Kai Xu, Jinsong Wang, Zongwei Liu, Zigang Shen, Jia Li, Yu Liu, Man Jiang, Zhi-Yuan Zhang, Zhiren Zhang
UNLABELLED: Experimental autoimmune neuritis (EAN) is the animal model of human acute inflammatory demyelinating polyradiculoneuropathies (AIDP), an auto-immune inflammatory demyelination disease of the peripheral nervous system (PNS) and the world's leading cause of acute autoimmune neuromuscular paralysis. EAN and AIDP are characterized by self-limitation with spontaneous recovery; however, endogenous pathways that regulate inflammation resolution in EAN and AIDP remain elusive. A pathway of endogenous mediators, especially resolvins and clearance of apoptotic cells, may be involved...
September 14, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27608686/clinical-profile-of-patients-requiring-prolonged-mechanical-ventilation-and-their-outcome-in-a-tertiary-care-medical-icu
#9
Chakor S Vora, Niteen D Karnik, Vishal Gupta, Milind Y Nadkar, Jaimala V Shetye
INTODUCTION: An increasing number of patients require mechanical ventilation and there has been a proportional increase in patients needing prolonged mechanical ventilation (ventilated for ≥ 21 days, for atleast 6 hours per day). It accounts for about 10% of all mechanically ventilated patients. Although these patients represent a smaller proportion of intensive care unit (ICU) patients, they consume substantial ICU resources. We studied etiology, metabolic and clinical profile, complications and outcome of these patients...
October 2015: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27596231/an-unusual-case-of-recurrent-guillain-barr%C3%A3-syndrome-with-normal-cerebrospinal-fluid-protein-levels-a-case-report
#10
Sonali Sihindi Chapa Gunatilake, Rohitha Gamlath, Harith Wimalaratna
BACKGROUND: Guillain-Barré syndrome is an acquired polyradiculo-neuropathy, often preceded by an antecedent event. It is a monophasic disease but a recurrence rate of 1-6 % is documented in a subset group of patients. Patients with Guillain-Barré syndrome show cerebrospinal fluid albuminocytologic dissociation. Normal cerebrospinal fluid protein levels during both initial and recurrent episodes of Guillain-Barré syndrome is a rare occurrence and has not been described earlier in the literature...
September 5, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27470955/-electrophysiological-subtypes-and-long-term-prognosis-of-guillain-barr%C3%A3-syndrome
#11
J Zhang, X J Song, H Q Hou, G J Tan, G Y Bian, B Li, L P Chen, L Wang, L Guo
OBJECTIVE: To assess the electrophysiological subtypes of Guillain-Barré syndrome (GBS) acute inflammatory demyelinating polyneuropathy (AIDP) and acute motor axonal neuropathy (AMAN), and long-term prognosis in northeastern China. METHODS: One hundred and eighteen patients with GBS were recruited between 2010 and 2012 and retrospectively reviewed. RESULTS: According to electrodiagnostic criteria, patients were classified as AMAN (49, 46...
July 5, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27464289/anti-ganglioside-antibodies-in-guillain-barr%C3%A3-syndrome-and-chronic-inflammatory-demyelinating-polyneuropathy-in-chinese-patients
#12
Chenghe Fan, Haiqiang Jin, Hongjun Hao, Feng Gao, Yongan Sun, Yuanyuan Lu, Yuanyuan Liu, Pu Lv, Wei Cui, Yuming Teng, Yining Huang
INTRODUCTION: We investigated the relationships between anti-ganglioside antibodies and Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyneuropathy (CIDP). METHODS: Samples from 48 patients diagnosed with GBS and 18 patients diagnosed with CIDP were retrospectively reviewed in China. RESULTS: In GBS patients, 62.5% were classified as having acute inflammatory demyelinating polyneuropathy (AIDP), 27.1% were found to have acute motor axonal neuropathy (AMAN), and 10...
July 27, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27460017/the-pathogenic-relevance-of-%C3%AE-m-integrin-in-guillain-barr%C3%A3-syndrome
#13
Chaoling Dong, Steven P Palladino, Eric Scott Helton, Eroboghene E Ubogu
The molecular determinants and mechanisms involved in leukocyte trafficking across the blood-nerve barrier (BNB) in the acute inflammatory demyelinating polyradiculoneuropathy (AIDP) variant of Guillain-Barré syndrome are incompletely understood. Prior work using a flow-dependent in vitro human BNB model demonstrated a crucial role for αM-integrin (CD11b)-intercellular adhesion molecule-1 interactions in AIDP patient leukocyte trafficking. The aim of this study is to directly investigate the biological relevance of CD11b in AIDP pathogenesis...
November 2016: Acta Neuropathologica
https://www.readbyqxmd.com/read/27413732/supramaximal-stimulus-intensity-as-a-diagnostic-tool-in-chronic-demyelinating-neuropathy
#14
Vivien Parker, Jodi Warman Chardon, Julie Mills, Claire Goldsmith, Pierre R Bourque
Objective. The ability to correctly identify chronic demyelinating neuropathy can have important therapeutic and prognostic significance. The stimulus intensity value required to obtain a supramaximal compound muscle action potential amplitude is a commonly acquired data point that has not been formally assessed as a diagnostic tool in routine nerve conduction studies to identify chronic neuropathies. We postulated that this value was significantly elevated in chronic demyelinating neuropathy. Methods. We retrospectively reviewed electrophysiology laboratory records to compare the stimulus intensity values recorded during median and ulnar motor nerve conduction studies...
2016: Neuroscience Journal
https://www.readbyqxmd.com/read/27314967/proximal-nerve-lesions-in-early-guillain-barr%C3%A3-syndrome-implications-for-pathogenesis-and-disease-classification
#15
José Berciano, María J Sedano, Ana L Pelayo-Negro, Antonio García, Pedro Orizaola, Elena Gallardo, Miguel Lafarga, María T Berciano, Bart C Jacobs
Guillain-Barré syndrome (GBS) is an acute-onset, immune-mediated disorder of the peripheral nervous system. In early GBS, arbitrarily established up to 10 days of disease onset, patients could exhibit selective manifestations due to involvement of the proximal nerves, including nerve roots, spinal nerves and plexuses. Such manifestations are proximal weakness, inaugural nerve trunk pain, and atypical electrophysiological patterns, which may lead to delayed diagnosis. The aim of this paper was to analyze the nosology of early GBS reviewing electrophysiological, autopsy and imaging studies, both in acute inflammatory demyelinating polyneuropathy (AIDP) and acute motor/motor-sensory axonal neuropathy (AMAN/AMSAN)...
June 17, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27298667/systemic-lupus-erythematosus-with-acute-inflammatory-demyelinating-polyneuropathy-a-case-report-and-review-of-the-literature
#16
Xiangling Li, Yanqiang Wang
We recently encountered a patient with acute inflammatory demyelinating polyneuropathy (AIDP) that was associated with systemic lupus erythematosus (SLE). A 34-year-old Chinese female with a 3-year history of SLE presented with acute bilateral leg weakness and paraparesis, and lost the ability to walk 1 day after noticing bilateral leg numbness and pain for 12 days. Physical examination revealed bilateral facial muscle paralysis, muscle strength in the legs with graded 1/5 proximally and 2/5 distally bilaterally and absence of deep tendon reflex in both knees and ankles...
July 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27278064/serial-electrophysiological-findings-in-guillain-barr%C3%A3-syndrome-not-fulfilling-aidp-or-aman-criteria
#17
Takafumi Hosokawa, Hideto Nakajima, Kiichi Unoda, Kazushi Yamane, Yoshimitsu Doi, Shimon Ishida, Fumiharu Kimura, Toshiaki Hanafusa
Guillain-Barré syndrome (GBS) is categorized into two major subtypes: acute inflammatory demyelinating polyneuropathy (AIDP) and acute motor axonal neuropathy (AMAN). However, a proportion of patients are electrophysiologically unclassified because of electrophysiological findings that do not fulfil AIDP or AMAN criteria, and underlying pathophysiological mechanisms and lesion distributions of unclassified patients are not well defined. The aims of this study are to elucidate disease pathophysiology and lesion distribution in unclassified patients...
September 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27247582/prognosis-of-guillain-barr%C3%A3-syndrome-in-children
#18
Mohammad Reza Salehiomran, Ali Nikkhah, Mohadese Mahdavi
OBJECTIVE: Guillain-Barre Syndrome (GBS) is an acute polyradiculoneuropathy characterized by progressive motor weakness of limbs and areflexia. In this study, our aim was to evaluate the clinical pattern and prognosis of children with Guillain-Barre syndrome. MATERIALS & METHODS: This cross-sectional study was conducted in the Pediatric Neurology Unit of Amirkola Children's Hospital, Babol, Iran during the period of 5 years from October 2008 to September 2013. We assessed the clinical features, results of electrodiagnostic tests, functional status, treatment and outcome of 17 children diagnosed with GBS...
2016: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/27238765/acute-inflammatory-demyelinating-polyradiculoneuropathy-in-a-newborn-infant
#19
Stavroula Anastasopoulou, Marie Lindefeldt, Marco Bartocci, Ronny Wickström
BACKGROUND: Acute inflammatory demyelinating polyneuropathy (AIDP), also known as Guillain-Barré syndrome, is an immune-mediated polyneuropathy usually triggered by infections or vaccinations. In childhood AIDP is commonly described after the first year of life. Here, we present a case of a newborn infant with AIDP manifestation directly after delivery. CASE STUDY: A newborn girl with a healthy mother, without known exposure to immunomodulating factors, was admitted to the neuropediatric department due to ascending hypotonia, weakness, pain and areflexia in the lower extremities...
December 0: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/27143409/the-pathogenesis-of-the-demyelinating-form-of-guillain-barre-syndrome-gbs-proteo-peptidomic-and-immunological-profiling-of-physiological-fluids
#20
Rustam H Ziganshin, Olga M Ivanova, Yakov A Lomakin, Alexey A Belogurov, Sergey I Kovalchuk, Igor V Azarkin, Georgij P Arapidi, Nikolay A Anikanov, Victoria O Shender, Mikhail A Piradov, Natalia A Suponeva, Anna A Vorobyeva, Alexander G Gabibov, Vadim T Ivanov, Vadim M Govorun
Acute inflammatory demyelinating polyneuropathy (AIDP) - the main form of Guillain-Barre syndrome-is a rare and severe disorder of the peripheral nervous system with an unknown etiology. One of the hallmarks of the AIDP pathogenesis is a significantly elevated cerebrospinal fluid (CSF) protein level. In this paper CSF peptidome and proteome in AIDP were analyzed and compared with multiple sclerosis and control patients. A total protein concentration increase was shown to be because of even changes in all proteins rather than some specific response, supporting the hypothesis of protein leakage from blood through the blood-nerve barrier...
July 2016: Molecular & Cellular Proteomics: MCP
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