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https://www.readbyqxmd.com/read/29153605/associations-between-tumor-necrosis-factor-%C3%AE-gene-polymorphisms-and-the-risk-of-guillain-barr%C3%A3-syndrome-and-its-subtypes-a-systematic-review-and-meta-analysis
#1
Ju Liu, Zhiyun Lian, Hongxi Chen, Ziyan Shi, Huiru Feng, Qin Du, Qin Zhang, Hongyu Zhou
This meta-analysis aimed to assess the relationship between tumor necrosis factor-α (TNF-α) polymorphisms and Guillain-Barré syndrome (GBS) or its subtypes of acute inflammatory demyelinating polyneuropathy (AIDP), acute motor axonal neuropathy (AMAN), and acute motor-sensory axonal neuropathy (AMSAN). A total of six studies with 1013 cases and 1029 controls were included. Our pooled data indicated that TNF-α 308G/A polymorphism was significantly associated with GBS, AMAN, and AMSAN but not with AIDP; TNF-α 857C/T polymorphism was significantly associated with AMAN but not with GBS or AIDP...
December 15, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29137897/elevated-serum-levels-of-endothelin-1-in-patients-with-chronic-inflammatory-demyelinating-polyneuropathy
#2
Chun-Wei Chang, Hsiu-Chuan Wu, Rong-Kuo Lyu, Yen-Shi Lo, Chiung-Mei Chen, Long-Sun Ro, Hong-Shiu Chang, Ching-Chang Huang, Ming-Feng Liao, Yih-Ru Wu, Hong-Chou Kuo, Chun-Che Chu, Yi-Ching Weng, Pei-Tsi Wei, Ai-Lun Lo, Kuo-Hsuan Chang
INTRODUCTION: A Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired, or non-hereditary, chronic demyelinating neuropathy. Currently, there is no reliable molecular biomarker that can identify CIDP patients as well as monitor disease severity. MATERIAL AND METHODS: We measured serum levels of endothelin-1 (ET-1), a factors involved in vasoconstrictive, inflammatory and nerve regenerative processes, in the serum of 20 CIDP, 21 acute inflammatory demyelinating polyneuropathy (AIDP), 37 multiple sclerosis (MS), and 10 Alzheimer's disease (AD) patients, as well as 26 healthy control (HC) subjects...
November 11, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29093388/an-adult-case-of-recurrent-guillain-barr%C3%A3-syndrome-with-anti-galactocerebroside-antibodies
#3
Hisashi Takahashi, Tadashi Kimura, Natsuko Yuki, Akira Yoshioka
A 79-year-old woman with a history of Guillain-Barré syndrome (GBS) developed somnolence and tetraparesis after pneumonia. Based on clinical and laboratory findings, she was diagnosed with complications of acute inflammatory demyelinating polyneuropathy (AIDP) and acute disseminated encephalomyelitis (ADEM). Anti-galactocerebroside (Gal-C) IgG antibodies were detected in her serum. Cases of recurrent GBS in patients who are positive for this antibody are extremely rare. The anti-Gal-C IgG antibodies likely played an important role in the pathogenesis of the AIDP and ADEM...
November 1, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29091318/early-electrophysiological-findings-in-acute-inflammatory-demyelinating-polyradiculoneuropathy-variant-of-guillain-barre-syndrome-in-the-pakistani-population-a-comparison-with-global-data
#4
Ahmed Wali, Sara Khan
Acute inflammatory demyelinating polyradiculoneuropathy (AIDP) and acute motor axonal neuropathy (AMAN) are the most common variants of Guillian Barre syndrome documented in the Asian population. However the variability of early neurophysiologic findings in the Asian population compared to western data has not been documented. Eighty seven cases of AIDP were retrospectively reviewed for their demographic, clinical, electrophysiological and laboratory data. Mean age of subjects was 31 ± 8 years with males more commonly affected...
November 1, 2017: Journal of the Peripheral Nervous System: JPNS
https://www.readbyqxmd.com/read/29053890/prospective-comparison-of-acute-motor-axonal-neuropathy-and-acute-inflammatory-demyelinating-polyradiculoneuropathy-in-140-children-with-guillain-barr%C3%A3-syndrome-in-india
#5
Jayantee Kalita, Mritunjai Kumar, Usha K Misra
INTRODUCTION: There have been few reports on subtypes of Guillain-Barré syndrome (GBS) in children. We compared clinical and laboratory findings of acute inflammatory demyelinating polyradiculoneuropathy (AIDP) and acute motor axonal neuropathy (AMAN). METHODS: One hundred forty children with GBS were included. Based on nerve conduction study (NCS) findings, patients were subclassified as AIDP, AMAN, acute motor sensory axonal neuropathy (AMSAN), and equivocal...
October 20, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29038133/did-jules-dejerine-describe-aman-at-the-end-of-the-19th-century
#6
Stéphane Mathis, Laurent Magy, Gwendal Le Masson, Jean-Michel Vallat
Guillain-Barré syndrome (GBS) is a heterogeneous group of acute immune-mediated neuropathies, including acute inflammatory demyelinating polyneuropathy (AIDP) and acute motor axonal neuropathy (AMAN). AMAN is an axonal subtype of GBS that has been known since the 1990s; this term was first used to describe a summer epidemic of acute ascending paralysis observed in children in northern China (and Mexico). It is pathologically characterized by noninflammatory axonal degeneration of the motor nerves (with little or no demyelination)...
October 17, 2017: Neurology
https://www.readbyqxmd.com/read/28968363/guillain-barr%C3%A3-syndrome
#7
Peter D Donofrio
PURPOSE OF REVIEW: This article reviews the current state of Guillain-Barré syndrome (GBS), including its clinical presentation, evaluation, pathophysiology, and treatment. RECENT FINDINGS: GBS is an acute/subacute-onset polyradiculoneuropathy typically presenting with sensory symptoms and weakness over several days, often leading to quadriparesis. Approximately 70% of patients report a recent preceding upper or lower respiratory tract infection or gastrointestinal illness...
October 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/28904571/transcranial-magnetic-stimulation-as-an-additional-diagnostic-tool-in-children-with-acute-inflammatory-demyelinating-polyneuropathy
#8
Voitenkov Vladislav Voitenkov, Klimkin Andrey, Skripchenko Natalia, Aksenova Anastasia
CONTEXT: The diagnosis of polyneuropathy may be challenging at the early stages of the disease. Despite electromyography (EMG) efficacy in the establishment of polyneuropathy diagnosis, in some cases, results are dubious and neurophysiologists may implement additional techniques to ensure that conduction is affected. AIMS: The aim of the study was to evaluate motor-evoked potential (MEP) characteristics in children with acute inflammatory demyelinating polyneuropathy (AIDP)...
April 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/28754297/acute-axonal-neuropathy-subtype-of-guillain-barr%C3%A3-syndrome-in-a-french-pediatric-series-adequate-follow-up-may-require-repetitive-electrophysiological-studies
#9
Judith Chareyre, Marie Hully, Hina Simonnet, Lucile Musset, Christine Barnerias, Manoelle Kossorotoff, Susana Quijano-Roy, Isabelle Desguerre, Cyril Gitiaux
Different subtypes of Guillain Barré Syndromes (GBSs) are defined by their electrophysiological characteristics, acute inflammatory demyelinating neuropathy (AIDP), and acute motor/motor-sensory axonal forms (AMAN/AMSAN) with either reversible nerve conduction failure (RCF) or axonal degeneration. Our aim was to describe initial clinical and electrophysiological characteristics of axonal forms of GBS in a pediatric population and their short- and long-term evolution. Electroneuromyogram (ENMG) results were collected at diagnosis and at two months of evolution and interpreted using the recently proposed pattern of RCF vs axonal degeneration...
July 17, 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/28690944/acute-inflammatory-demyelinating-polyneuroradiculopathy-with-ipilimumab-in-metastatic-melanoma-a-case-report-and-review-of-literature
#10
Chintan Rupareliya, Syeda Naqvi, Vishal B Jani
Ipilimumab (Bristol-Myers Squibb Co., New York, NY) is a novel anticancer medication used for the treatment of metastatic melanoma. The exact mechanism of its action remains unclear; however, data from previous clinical trials postulates the immunomodulatory activity of ipilimumab to enhance therapeutic effectiveness. Ipilimumab was approved by the Food and Drug Administration (FDA) in March 2011 for use in stage III and IV of unresectable metastatic melanoma. We report a single case of acute inflammatory demyelinating polyneuroradiculopthy (AIDP) in the patient treated with ipilimumab for recurrent metastatic melanoma...
June 5, 2017: Curēus
https://www.readbyqxmd.com/read/28647707/hepatitis-e-virus-and-neurological-disorders
#11
REVIEW
Brendan N Mclean, James Gulliver, Harry R Dalton
Hepatitis E is the most common cause of hepatitis worldwide. While originally considered a disease of developing countries, it is increasingly recognised in developed countries, probably related to contaminated pork meat, and where infection is often asymptomatic. However, several non-liver manifestations have become apparent, the most important of which are neurological, including Guillain-Barré syndrome (acute inflammatory demyelinating polyradiculoneuropathy (AIDP)), neuralgic amyotrophy and meningoencephalitis...
August 2017: Practical Neurology
https://www.readbyqxmd.com/read/28639596/guillain-barre-syndrome-demographics-clinical-profile-seasonal-variation-in-a-tertiary-care-centre-of-central-india
#12
Manisha Shrivastava, Shah Nehal, Navaid Seema
BACKGROUND & OBJECTIVES: Guillain-Barre syndrome (GBS) is an autoimmune disease and a recognized cause of generalized progressive paralysis worldwide. The present study was aimed to document the clinical findings, demographics and seasonal variations amongst the patients with GBS during the hospital stay. METHODS: A retrospective analysis of 66 referred cases diagnosed as GBS was conducted. Medical records and the data related to age, sex, antecedent illness, duration of symptoms before admission, muscle power graded by the Medical Research Council scale, functional scores, details of Intensive Care Unit complications and need for ventilation were obtained...
February 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28588819/three-cases-of-acute-distal-demyelinating-neuropathy-with-recovery
#13
Emilia Österlund-Tauriala, Juhani V Partanen
Guillain-Barré syndrome (GBS) may present as distal acute inflammatory demyelinating polyradiculoneuropathy (AIDP), with severe distal demyelination of the peripheral nerves in the absence of radiculitis. Clinical course is benign, and prognosis seems favorable, but nerve conduction studies (NCS) findings at nadir may resemble some chronic forms of polyneuropathy, so close follow-up during recovery is needed.
June 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28569385/engaging-indigenous-families-in-a-community-based-indigenous-early-childhood-programme-in-british-columbia-canada-a-cultural-safety-perspective
#14
Alison J Gerlach, Annette J Browne, Margo Greenwood
This article is part of a larger study that explored how an Indigenous early intervention programme in British Columbia (BC), Canada, known as the 'Aboriginal Infant Development Program' (AIDP), influenced family and children's health and well-being and was responsive to child health inequities. Postcolonial feminist and Indigenous feminist perspectives provided a critical analytical lens to this qualitative inquiry. The study was undertaken with AIDPs based in diverse community organisations located in off-reserve urban municipalities throughout the province of BC...
June 1, 2017: Health & Social Care in the Community
https://www.readbyqxmd.com/read/28527161/prognostic-indicators-of-response-to-plasmapheresis-in-patients-of-guillain-barre-syndrome
#15
H B Prasad, R T Borse, A N Avate, Assistant Professor In Medicine Palasdeokar
INTRODUCTION: Plasmapheresis is an important modality for the treatment of GBS. Moreover the response to this treatment modality is not same in all cases. We therefore studied the various prognostic indicators of response to plasmapheresis in patients of Guillain Barre Syndrome. MATERIAL AND METHODS: 40 patients were included in the study. Thorough clinical examination was done. Nerve conduction was done to find out the type of neuropathy. All were then given plasmapheresis...
April 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28487747/a-predictive-model-for-guillain-barr%C3%A3-syndrome-based-on-single-learning-algorithms
#16
Juana Canul-Reich, Juan Frausto-Solís, José Hernández-Torruco
Background. Guillain-Barré Syndrome (GBS) is a potentially fatal autoimmune neurological disorder. The severity varies among the four main subtypes, named as Acute Inflammatory Demyelinating Polyneuropathy (AIDP), Acute Motor Axonal Neuropathy (AMAN), Acute Motor Sensory Axonal Neuropathy (AMSAN), and Miller-Fisher Syndrome (MF). A proper subtype identification may help to promptly carry out adequate treatment in patients. Method. We perform experiments with 15 single classifiers in two scenarios: four subtypes' classification and One versus All (OvA) classification...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28397393/early-discrimination-of-sensorimotor-guillain-barr%C3%A3-syndrome-into-demyelinating-or-axonal-subtype-by-automated-nerve-excitability-testing
#17
So Young Pyun, Mi-Ri Kang, Joo Young Lee, Kim Jong Kuk, Seong-Il Oh, Jong Seok Bae
In the early stage of disease, differentiating acute inflammatory demyelinating polyneuropathy (AIDP) and acute motor sensory axonal neuropathy (AMSAN) using only a conventional nerve conduction studies (NCS) may be difficult. We evaluated the differences in the motor axonal excitability properties of 16 cases of sensorimotor Guillain-Barré syndrome by nerve excitability testing (NET). The antiganglioside antibody assay and follow-up NCS resulted in 12 patients diagnosed as AIDP and 4 patients as AMSAN. Clinical and excitability parameters in each group were compared with those in 30 normal controls...
April 11, 2017: Journal of the Peripheral Nervous System: JPNS
https://www.readbyqxmd.com/read/28225085/aidp-a-novel-n-acyl-homoserine-lactonase-gene-from-antarctic-planococcus-sp
#18
Wah Seng See-Too, Robson Ee, Yan-Lue Lim, Peter Convey, David A Pearce, Wai-Fong Yin, Kok-Gan Chan
Planococcus is a Gram-positive halotolerant bacterial genus in the phylum Firmicutes, commonly found in various habitats in Antarctica. Quorum quenching (QQ) is the disruption of bacterial cell-to-cell communication (known as quorum sensing), which has previously been described in mesophilic bacteria. This study demonstrated the QQ activity of a psychrotolerant strain, Planococcus versutus strain L10.15(T), isolated from a soil sample obtained near an elephant seal wallow in Antarctica. Whole genome analysis of this bacterial strain revealed the presence of an N-acyl homoserine lactonase, an enzyme that hydrolyzes the ester bond of the homoserine lactone of N-acyl homoserine lactone (AHLs)...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28167198/analysis-of-serum-interleukin-27-and-interleukin-35-concentrations-in-patients-with-guillain-barr%C3%A3-syndrome
#19
Lin-Jie Zhang, Hui-Yue Guo, Da-Qi Zhang, Rong Wang, Ting Li, Li-Min Li, Dong-Mei Suo, Li Yang
BACKGROUNDS: Guillain-Barré syndrome (GBS) is a postinfectious immune-mediated peripheral neuropathy. Interleukin (IL)-27 and IL-35 have been recognized as novel members of IL-12 family. We evaluated the serum and cerebral spinal fluid (CFS) concentrations of IL-27 and IL-35 in GBS and analyze their correlations with clinical characteristics. METHODS: Serum samples from 50 patients with GBS including 9 acute inflammatory demyelinating polyradiculoneuropathy (AIDP), 33 acute motor axonal neuropathy (AMAN) and 8 unclassified and 35 age- and sex-matched healthy controls were collected...
February 4, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27939129/guillain-barr%C3%A3-syndrome-is-induced-in-non-obese-diabetic-nod-mice-following-campylobacter-jejuni-infection-and-is-exacerbated-by-antibiotics
#20
J L St Charles, J A Bell, B J Gadsden, A Malik, H Cooke, L K Van de Grift, H Y Kim, E J Smith, L S Mansfield
Campylobacter jejuni is a leading cause of bacterial gastroenteritis linked to several serious autoimmune sequelae such as the peripheral neuropathies Guillain Barré syndrome (GBS) and Miller Fisher syndrome (MFS). We hypothesized that GBS and MFS can result in NOD wild type (WT) mice or their congenic interleukin (IL)-10 or B7-2 knockouts secondary to C. jejuni infection. Mice were gavaged orally with C. jejuni strains HB93-13 and 260.94 from patients with GBS or CF93-6 from a patient with MFS and assessed for clinical neurological signs and phenotypes, anti-ganglioside antibodies, and cellular infiltrates and lesions in gut and peripheral nerve tissues...
February 2017: Journal of Autoimmunity
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